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Keyue Shen

Photo of Keyue Shen
Title(s)Associate Professor Biomedical Engineering
SchoolViterbi School of Engineering, Bme
Address1042 Downey Way
University Park Campus
Los Angeles CA 90089
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    Keyue Shen is an Associate Professor at the Department of Biomedical Engineering of USC Viterbi School of Engineering. He is a Full Member of the USC Norris Comprehensive Cancer Center. He received his Bachelor of Engineering in Mechanical Engineering (2001) and Master of Science in Biophysics (2004) from Tsinghua University of China. He earned his Ph.D. degree in Biomedical Engineering in the Department of Biomedical Engineering at Columbia University in 2010. He completed his postdoctoral training in the Center for Engineering in Medicine at Harvard Medical School and Massachusetts General Hospital (MGH), from 2010-2014. He joined the USC faculty in 2015.

    Dr. Shen received an MGH Fund for Medical Discovery Award in 2012, a Broad Innovation Award in 2016, a Marni Levine Memorial Research Career Development Award from STOP CANCER in 2017, an NIH Trailblazer Award in 2017, and a Rising Star Award from the Biomedical Engineering Society-Cellular and Molecular Bioengineering Conference in 2020. His research interests are in developing in vitro microengineered models of hypoxic tumor microenvironments and stem cell niches for applications in immune and cancer therapeutics, imaging-based biomarkers for cancer and stem cells, and artificial intelligence (AI)-based models and approaches for clinical and basic research applications.
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    (PQ5) Microenvironmental Regulation of Mitochondrial Heterogeneity in Cancer Metastasis
    NIH R01CA220012Sep 20, 2019 - Aug 31, 2024
    Role: Principal Investigator
    Artificial Stromal Cell for Hematopoietic Stem Cell Expansion
    NIH R21EB024748Aug 1, 2017 - Apr 30, 2021
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Microfabricated Organ-Specific Models of Tumor Microenvironments. Annu Rev Biomed Eng. 2025 05; 27(1):307-333. Oh JM, Park Y, Lee J, Shen K. PMID: 40310890; PMCID: PMC12184098.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. A micro-metabolic rewiring assay for assessing hypoxia-associated cancer metabolic heterogeneity. Bioact Mater. 2025 Jun; 48:493-509. Oh JM, Guo T, Begum HM, Marty SE, Sha L, Kilic C, Zhou H, Dou Y, Shen K. PMID: 40093303; PMCID: PMC11910375.
      View in: PubMed   Mentions:
    3. Profiling paracrine interactions between hypoxic and normoxic skeletal muscle tissue in a microphysiological system fabricated from 3D printed components. Lab Chip. 2025 Jan 14; 25(2):212-224. Rexius-Hall ML, Madrigal MD, Kilic CY, Shen K, McCain ML. PMID: 39665980; PMCID: PMC11887996.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. Label-free metabolic optical biomarkers track stem cell fate transition in real time. Sci Adv. 2024 05 10; 10(19):eadi6770. Zhou H, Li I, Bramlett CS, Wang B, Hao J, Yen DP, Ando Y, Fraser SE, Lu R, Shen K. PMID: 38718114; PMCID: PMC11078180.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    5. Hypoxic 3D Tumor Model for Evaluating of CAR-T Cell Therapy In Vitro. Methods Mol Biol. 2024; 2748:119-134. Oh JM, Shen K. PMID: 38070112.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Cleanroom-Free Microfluidic Device for Natural Induction of Hypoxia in 2D and 3D Tumor Models. Methods Mol Biol. 2024; 2755:227-247. Oh JM, Shen K. PMID: 38319582.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Ectopic Expression of a Truncated Isoform of Hair Keratin 81 in Breast Cancer Alters Biophysical Characteristics to Promote Metastatic Propensity. Adv Sci (Weinh). 2024 02; 11(5):e2300509. Kang DS, Moriarty A, Wang YJ, Thomas A, Hao J, Unger BA, Klotz R, Ahmmed S, Amzaleg Y, Martin S, Vanapalli S, Xu K, Smith A, Shen K, Yu M. PMID: 37949677; PMCID: PMC10837353.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    8. Quantifying COVID-19 policy impacts on subjective well-being during the early phase of the pandemic: A cross-sectional analysis of United States survey data from March to August 2020. PLoS One. 2023; 18(9):e0291494. Shen K, Kejriwal M. PMID: 37733714; PMCID: PMC10513291.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    9. Intracellular and microenvironmental regulation of mitochondrial membrane potential in cancer cells. WIREs Mech Dis. 2023 May-Jun; 15(3):e1595. Begum HM, Shen K. PMID: 36597256; PMCID: PMC10176868.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    10. Recapitulating Tumor Hypoxia in a Cleanroom-Free, Liquid-Pinning-Based Microfluidic Tumor Model. ACS Biomater Sci Eng. 2022 07 11; 8(7):3107-3121. Oh JM, Begum HM, Liu YL, Ren Y, Shen K. PMID: 35678715; PMCID: PMC9299272.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    11. Manipulation and Mechanical Deformation of Leukemia Cells by High-Frequency Ultrasound Single Beam. IEEE Trans Ultrason Ferroelectr Freq Control. 2022 06; 69(6):1889-1897. Zeng Y, Hao J, Zhang J, Jiang L, Youn S, Lu G, Yan D, Kang H, Sun Y, Shung KK, Shen K, Zhou Q. PMID: 35468061; PMCID: PMC9753557.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. A Pillar-Free Diffusion Device for Studying Chemotaxis on Supported Lipid Bilayers. Micromachines (Basel). 2021 Oct 16; 12(10). Hao J, Zhao W, Oh JM, Shen K. PMID: 34683305; PMCID: PMC8538285.
      View in: PubMed   Mentions:
    13. E-Cadherin Regulates Mitochondrial Membrane Potential in Cancer Cells. Cancers (Basel). 2021 Oct 09; 13(20). Begum HM, Mariano C, Zhou H, Shen K. PMID: 34680202; PMCID: PMC8534231.
      View in: PubMed   Mentions: 5  
    14. Engineering a Vascularized Hypoxic Tumor Model for Therapeutic Assessment. Cells. 2021 08 26; 10(9). Ando Y, Oh JM, Zhao W, Tran M, Shen K. PMID: 34571851; PMCID: PMC8468635.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    15. Membrane-bound SCF and VCAM-1 synergistically regulate the morphology of hematopoietic stem cells. J Cell Biol. 2021 10 04; 220(10). Hao J, Zhou H, Nemes K, Yen D, Zhao W, Bramlett C, Wang B, Lu R, Shen K. PMID: 34402812; PMCID: PMC8374872.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    16. Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. Cell Rep. 2021 Jul 27; 36(4):109475. Martirosian V, Deshpande K, Zhou H, Shen K, Smith K, Northcott P, Lin M, Stepanosyan V, Das D, Remsik J, Isakov D, Boire A, De Feyter H, Hurth K, Li S, Wiemels J, Wiemels J, Nakamura B, Shao L, Danilov C, Chen T, Neman J. PMID: 34320362.
      View in: PubMed   Mentions: 3     Fields:    
    17. Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. Cell Rep. 2021 06 29; 35(13):109302. Martirosian V, Deshpande K, Zhou H, Shen K, Smith K, Northcott P, Lin M, Stepanosyan V, Das D, Remsik J, Isakov D, Boire A, De Feyter H, Hurth K, Li S, Wiemels J, Wiemels J, Nakamura B, Shao L, Danilov C, Chen T, Neman J. PMID: 34192534; PMCID: PMC8848833.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    18. Engineered in vitro tumor models for cell-based immunotherapy. Acta Biomater. 2021 09 15; 132:345-359. Ando Y, Mariano C, Shen K. PMID: 33857692; PMCID: PMC8434941.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    19. Bioengineering tools for probing intracellular events in T lymphocytes. WIREs Mech Dis. 2021 07; 13(4):e1510. Zhang X, Mariano CF, Ando Y, Shen K. PMID: 33073545; PMCID: PMC8297511.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    20. CCR2-targeted micelles for anti-cancer peptide delivery and immune stimulation. J Control Release. 2021 01 10; 329:614-623. Trac N, Chen LY, Zhang A, Liao CP, Poon C, Wang J, Ando Y, Joo J, Garri C, Shen K, Kani K, Gross ME, Chung EJ. PMID: 33011241; PMCID: PMC8491563.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    21. Non-invasive Optical Biomarkers Distinguish and Track the Metabolic Status of Single Hematopoietic Stem Cells. iScience. 2020 Feb 21; 23(2):100831. Zhou H, Nguyen L, Arnesano C, Ando Y, Raval M, Rodgers JT, Fraser S, Lu R, Shen K. PMID: 31982780; PMCID: PMC6994633.
      View in: PubMed   Mentions: 10  
    22. Spatial Regulation of Mitochondrial Heterogeneity by Stromal Confinement in Micropatterned Tumor Models. Sci Rep. 2019 08 01; 9(1):11187. Begum HM, Ta HP, Zhou H, Ando Y, Kang D, Nemes K, Mariano CF, Hao J, Yu M, Shen K. PMID: 31371796; PMCID: PMC6671984.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    23. Evaluating CAR-T Cell Therapy in a Hypoxic 3D Tumor Model. Adv Healthc Mater. 2019 03; 8(5):e1900001. Ando Y, Siegler EL, Ta HP, Cinay GE, Zhou H, Gorrell KA, Au H, Jarvis BM, Wang P, Shen K. PMID: 30734529; PMCID: PMC6448565.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    24. A Microdevice Platform Recapitulating Hypoxic Tumor Microenvironments. Sci Rep. 2017 11 09; 7(1):15233. Ando Y, Ta HP, Yen DP, Lee SS, Raola S, Shen K. PMID: 29123197; PMCID: PMC5680268.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    25. A cost-effective micromilling platform for rapid prototyping of microdevices. Technology (Singap World Sci). 2016 Dec; 4(4):234-239. Yen DP, Ando Y, Shen K. PMID: 28317005; PMCID: PMC5356927.
      View in: PubMed   Mentions: 15  
    26. Suicide Gene-Engineered Stromal Cells Reveal a Dynamic Regulation of Cancer Metastasis. Sci Rep. 2016 Feb 19; 6:21239. Shen K, Luk S, Elman J, Murray R, Mukundan S, Parekkadan B. PMID: 26893143; PMCID: PMC4759812.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    27. Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays. Nat Commun. 2014 Dec 09; 5:5662. Shen K, Luk S, Hicks DF, Elman JS, Bohr S, Iwamoto Y, Murray R, Pena K, Wang F, Seker E, Weissleder R, Yarmush ML, Toner M, Sgroi D, Parekkadan B. PMID: 25489927; PMCID: PMC4261930.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    28. Modulation of cellular stress response via the erythropoietin/CD131 heteroreceptor complex in mouse mesenchymal-derived cells. J Mol Med (Berl). 2015 Feb; 93(2):199-210. Bohr S, Patel SJ, Vasko R, Shen K, Iracheta-Vellve A, Lee J, Bale SS, Chakraborty N, Brines M, Cerami A, Berthiaume F, Yarmush ML. PMID: 25373867; PMCID: PMC4482224.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    29. CD28 and CD3 have complementary roles in T-cell traction forces. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):2241-6. Bashour KT, Gondarenko A, Chen H, Shen K, Liu X, Huse M, Hone JC, Kam LC. PMID: 24469820; PMCID: PMC3926067.
      View in: PubMed   Mentions: 143     Fields:    Translation:HumansCells
    30. Cross talk between CD3 and CD28 is spatially modulated by protein lateral mobility. Mol Cell Biol. 2014 Mar; 34(6):955-64. Bashour KT, Tsai J, Shen K, Lee JH, Sun E, Milone MC, Dustin ML, Kam LC. PMID: 24379441; PMCID: PMC3958039.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    31. Substrate rigidity regulates human T cell activation and proliferation. J Immunol. 2012 Aug 01; 189(3):1330-9. O'Connor RS, Hao X, Shen K, Bashour K, Akimova T, Hancock WW, Kam LC, Milone MC. PMID: 22732590; PMCID: PMC3401283.
      View in: PubMed   Mentions: 172     Fields:    Translation:HumansCells
    32. Self-aligned supported lipid bilayers for patterning the cell-substrate interface. J Am Chem Soc. 2009 Sep 23; 131(37):13204-5. Shen K, Tsai J, Shi P, Kam LC. PMID: 19708648; PMCID: PMC2756520.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    33. Nanoengineering of Immune Cell Function. Mater Res Soc Symp Proc. 2009 Jan 01; 1209. Shen K, Milone MC, Dustin ML, Kam LC. PMID: 21562611; PMCID: PMC3090082.
      View in: PubMed   Mentions: 4  
    34. Microcontact printing of proteins for cell biology. J Vis Exp. 2008 Dec 05; (22). Shen K, Qi J, Kam LC. PMID: 19229168; PMCID: PMC2762926.
      View in: PubMed   Mentions: 14     Fields:    
    35. Micropatterning of costimulatory ligands enhances CD4+ T cell function. Proc Natl Acad Sci U S A. 2008 Jun 03; 105(22):7791-6. Shen K, Thomas VK, Dustin ML, Kam LC. PMID: 18505845; PMCID: PMC2409411.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    36. Local presentation of L1 and N-cadherin in multicomponent, microscale patterns differentially direct neuron function in vitro. Dev Neurobiol. 2007 Nov; 67(13):1765-76. Shi P, Shen K, Kam LC. PMID: 17659593.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
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