Keyue Shen

Title(s)Associate Professor Biomedical Engineering
SchoolViterbi School of Engineering, Bme
Address1042 Downey Way
University Park Campus
Los Angeles CA 90089
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    Shen Lab Website

    Keyue Shen is an Assistant Professor at the Department of Biomedical Engineering of USC Viterbi School of Engineering. He is an Associate Member of the USC Norris Comprehensive Cancer Center and a Principle Investigator of USC Stem Cell Biology and Regenerative Medicine (courtesy). He received his Bachelor of Engineering in Mechanical Engineering (2001) and Master of Science in Biophysics (2004) from Tsinghua University of China. He earned his Ph.D. degree in Biomedical Engineering in the Department of Biomedical Engineering at Columbia University in 2010. He completed his postdoctoral training in the Center for Engineering in Medicine at Harvard Medical School and Massachusetts General Hospital, from 2010-2014. He joined the USC faculty in 2015.

    Dr. Shen received an MGH Fund for Medical Discovery Award in 2012, a Broad Innovation Award in 2016, and the 2017 Marni Levine Memorial Research Career Development Award from STOP CANCER. His research interests are in developing in vitro microengineered models of cell microenvironments in immune system, cancer and stem cell niches for applications in immune and cancer therapeutics, as well as regenerative medicine.
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    (PQ5) Microenvironmental Regulation of Mitochondrial Heterogeneity in Cancer Metastasis
    NIH R01CA220012Sep 20, 2019 - Aug 31, 2024
    Role: Principal Investigator
    Artificial Stromal Cell for Hematopoietic Stem Cell Expansion
    NIH R21EB024748Aug 1, 2017 - Apr 30, 2021
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hypoxic 3D Tumor Model for Evaluating of CAR-T Cell Therapy In Vitro. Methods Mol Biol. 2024; 2748:119-134. Oh JM, Shen K. PMID: 38070112.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Cleanroom-Free Microfluidic Device for Natural Induction of Hypoxia in 2D and 3D Tumor Models. Methods Mol Biol. 2024; 2755:227-247. Oh JM, Shen K. PMID: 38319582.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Quantifying confidence shifts in a BERT-based question answering system evaluated on perturbed instances. PLoS One. 2023; 18(12):e0295925. Shen K, Kejriwal M. PMID: 38117790; PMCID: PMC10732378.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Ectopic Expression of a Truncated Isoform of Hair Keratin 81 in Breast Cancer Alters Biophysical Characteristics to Promote Metastatic Propensity. Adv Sci (Weinh). 2024 Feb; 11(5):e2300509. Kang DS, Moriarty A, Wang YJ, Thomas A, Hao J, Unger BA, Klotz R, Ahmmed S, Amzaleg Y, Martin S, Vanapalli S, Xu K, Smith A, Shen K, Yu M. PMID: 37949677; PMCID: PMC10837353.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Quantifying COVID-19 policy impacts on subjective well-being during the early phase of the pandemic: A cross-sectional analysis of United States survey data from March to August 2020. PLoS One. 2023; 18(9):e0291494. Shen K, Kejriwal M. PMID: 37733714; PMCID: PMC10513291.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    6. Using conditional inference to quantify interaction effects of socio-demographic covariates of US COVID-19 vaccine hesitancy. PLOS Glob Public Health. 2023; 3(5):e0001151. Shen K, Kejriwal M. PMID: 37172006; PMCID: PMC10180637.
      View in: PubMed   Mentions: 1  
    7. Intracellular and microenvironmental regulation of mitochondrial membrane potential in cancer cells. WIREs Mech Dis. 2023 May-Jun; 15(3):e1595. Begum HM, Shen K. PMID: 36597256; PMCID: PMC10176868.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    8. Recapitulating Tumor Hypoxia in a Cleanroom-Free, Liquid-Pinning-Based Microfluidic Tumor Model. ACS Biomater Sci Eng. 2022 07 11; 8(7):3107-3121. Oh JM, Begum HM, Liu YL, Ren Y, Shen K. PMID: 35678715; PMCID: PMC9299272.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    9. Manipulation and Mechanical Deformation of Leukemia Cells by High-Frequency Ultrasound Single Beam. IEEE Trans Ultrason Ferroelectr Freq Control. 2022 06; 69(6):1889-1897. Zeng Y, Hao J, Zhang J, Jiang L, Youn S, Lu G, Yan D, Kang H, Sun Y, Shung KK, Shen K, Zhou Q. PMID: 35468061; PMCID: PMC9753557.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. A Pillar-Free Diffusion Device for Studying Chemotaxis on Supported Lipid Bilayers. Micromachines (Basel). 2021 Oct 16; 12(10). Hao J, Zhao W, Oh JM, Shen K. PMID: 34683305; PMCID: PMC8538285.
      View in: PubMed   Mentions:
    11. E-Cadherin Regulates Mitochondrial Membrane Potential in Cancer Cells. Cancers (Basel). 2021 Oct 09; 13(20). Begum HM, Mariano C, Zhou H, Shen K. PMID: 34680202; PMCID: PMC8534231.
      View in: PubMed   Mentions: 4  
    12. Engineering a Vascularized Hypoxic Tumor Model for Therapeutic Assessment. Cells. 2021 08 26; 10(9). Ando Y, Oh JM, Zhao W, Tran M, Shen K. PMID: 34571851; PMCID: PMC8468635.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    13. Membrane-bound SCF and VCAM-1 synergistically regulate the morphology of hematopoietic stem cells. J Cell Biol. 2021 10 04; 220(10). Hao J, Zhou H, Nemes K, Yen D, Zhao W, Bramlett C, Wang B, Lu R, Shen K. PMID: 34402812; PMCID: PMC8374872.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    14. Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. Cell Rep. 2021 Jul 27; 36(4):109475. Martirosian V, Deshpande K, Zhou H, Shen K, Smith K, Northcott P, Lin M, Stepanosyan V, Das D, Remsik J, Isakov D, Boire A, De Feyter H, Hurth K, Li S, Wiemels J, Wiemels J, Nakamura B, Shao L, Danilov C, Chen T, Neman J. PMID: 34320362.
      View in: PubMed   Mentions: 2     Fields:    
    15. Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. Cell Rep. 2021 06 29; 35(13):109302. Martirosian V, Deshpande K, Zhou H, Shen K, Smith K, Northcott P, Lin M, Stepanosyan V, Das D, Remsik J, Isakov D, Boire A, De Feyter H, Hurth K, Li S, Wiemels J, Wiemels J, Nakamura B, Shao L, Danilov C, Chen T, Neman J. PMID: 34192534; PMCID: PMC8848833.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    16. Engineered in vitro tumor models for cell-based immunotherapy. Acta Biomater. 2021 09 15; 132:345-359. Ando Y, Mariano C, Shen K. PMID: 33857692; PMCID: PMC8434941.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    17. Bioengineering tools for probing intracellular events in T lymphocytes. WIREs Mech Dis. 2021 07; 13(4):e1510. Zhang X, Mariano CF, Ando Y, Shen K. PMID: 33073545; PMCID: PMC8297511.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    18. CCR2-targeted micelles for anti-cancer peptide delivery and immune stimulation. J Control Release. 2021 01 10; 329:614-623. Trac N, Chen LY, Zhang A, Liao CP, Poon C, Wang J, Ando Y, Joo J, Garri C, Shen K, Kani K, Gross ME, Chung EJ. PMID: 33011241; PMCID: PMC8491563.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    19. Non-invasive Optical Biomarkers Distinguish and Track the Metabolic Status of Single Hematopoietic Stem Cells. iScience. 2020 Feb 21; 23(2):100831. Zhou H, Nguyen L, Arnesano C, Ando Y, Raval M, Rodgers JT, Fraser S, Lu R, Shen K. PMID: 31982780; PMCID: PMC6994633.
      View in: PubMed   Mentions: 7  
    20. Spatial Regulation of Mitochondrial Heterogeneity by Stromal Confinement in Micropatterned Tumor Models. Sci Rep. 2019 08 01; 9(1):11187. Begum HM, Ta HP, Zhou H, Ando Y, Kang D, Nemes K, Mariano CF, Hao J, Yu M, Shen K. PMID: 31371796; PMCID: PMC6671984.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    21. Evaluating CAR-T Cell Therapy in a Hypoxic 3D Tumor Model. Adv Healthc Mater. 2019 03; 8(5):e1900001. Ando Y, Siegler EL, Ta HP, Cinay GE, Zhou H, Gorrell KA, Au H, Jarvis BM, Wang P, Shen K. PMID: 30734529; PMCID: PMC6448565.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    22. A Microdevice Platform Recapitulating Hypoxic Tumor Microenvironments. Sci Rep. 2017 11 09; 7(1):15233. Ando Y, Ta HP, Yen DP, Lee SS, Raola S, Shen K. PMID: 29123197; PMCID: PMC5680268.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    23. A cost-effective micromilling platform for rapid prototyping of microdevices. Technology (Singap World Sci). 2016 Dec; 4(4):234-239. Yen DP, Ando Y, Shen K. PMID: 28317005; PMCID: PMC5356927.
      View in: PubMed   Mentions: 13  
    24. Suicide Gene-Engineered Stromal Cells Reveal a Dynamic Regulation of Cancer Metastasis. Sci Rep. 2016 Feb 19; 6:21239. Shen K, Luk S, Elman J, Murray R, Mukundan S, Parekkadan B. PMID: 26893143; PMCID: PMC4759812.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    25. Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays. Nat Commun. 2014 Dec 09; 5:5662. Shen K, Luk S, Hicks DF, Elman JS, Bohr S, Iwamoto Y, Murray R, Pena K, Wang F, Seker E, Weissleder R, Yarmush ML, Toner M, Sgroi D, Parekkadan B. PMID: 25489927; PMCID: PMC4261930.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    26. Modulation of cellular stress response via the erythropoietin/CD131 heteroreceptor complex in mouse mesenchymal-derived cells. J Mol Med (Berl). 2015 Feb; 93(2):199-210. Bohr S, Patel SJ, Vasko R, Shen K, Iracheta-Vellve A, Lee J, Bale SS, Chakraborty N, Brines M, Cerami A, Berthiaume F, Yarmush ML. PMID: 25373867; PMCID: PMC4482224.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    27. Self-aligned supported lipid bilayers for patterning the cell-substrate interface. J Am Chem Soc. 2009 Sep 23; 131(37):13204-5. Shen K, Tsai J, Shi P, Kam LC. PMID: 19708648; PMCID: PMC2756520.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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