Kian Kani, PhD

Title(s)Assistant Professor of Research Medicine
SchoolKeck School of Medicine of Usc
Address12414 Exposition Blvd.
Off Campus
Los Angeles CA 90064
Phone+1 323 442 2539
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    Collapse Biography 
    Collapse Awards and Honors
    Ellis Island Honor Society2023Medals of Honor
    University of Chicago2022Outstanding Educator
    European Molecular Biology Organization2009Oral Presentation Award
    Human Proteome Organization2008Outstanding Poster Award
    Department of Biological Chemistry, UCLA2003David Sigman Award
    University of Hartford1996Summa Cum Laude
    University of Hartford1994Gengras Academic Scholarship
    1992Thomas Cook Rewards and Recognition Award

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    Collapse Overview
    Cancer has been traditionally classified based on the organ site of origin; breast cancer is different from prostate cancer which is distinct from lung cancer and so on. Over the past several years however, cancer research has introduced reclassification of tumors based on the signaling pathway(s) that causes malignant transformation. As a result, medical oncologists can prescribe drugs that specifically target the aberrant signaling pathway irrespective of the location of the tumor.

    Modern cancer therapeutics have therefore become “targeted” rather than “systemic.” This has brought upon a significant paradigm shift in medical treatment decisions and spurred oncology research to identify biomarkers indicative of signaling pathway activation. The Kani research group utilizes state-of-the-art proteomic techniques in order to identify and characterize novel cancer biomarkers. Our work focuses on the androgen receptor and human epidermal growth factor receptor signaling axes in prostate, lung, breast, ovarian, and pancreatic cancers. Our goal is to enhance patient outcome by empowering medical oncologist with tools and knowledge necessary for personalized medicine.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. CCR2-targeted micelles for anti-cancer peptide delivery and immune stimulation. J Control Release. 2021 01 10; 329:614-623. Trac N, Chen LY, Zhang A, Liao CP, Poon C, Wang J, Ando Y, Joo J, Garri C, Shen K, Kani K, Gross ME, Chung EJ. PMID: 33011241; PMCID: PMC8491563.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    2. Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. Oncogene. 2019 04; 38(16):3003-3018. Tiemann K, Garri C, Lee SB, Malihi PD, Park M, Alvarez RM, Yap LP, Mallick P, Katz JE, Gross ME, Kani K. PMID: 30575818; PMCID: PMC7523706.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    3. Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays. J Vis Exp. 2018 09 19; (139). Tiemann K, Garri C, Wang J, Clarke L, Kani K. PMID: 30295648; PMCID: PMC6235240.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Identification, characterization and application of a new peptide against anterior gradient homolog 2 (AGR2). Oncotarget. 2018 Jun 08; 9(44):27363-27379. Garri C, Howell S, Tiemann K, Tiffany A, Jalali-Yazdi F, Alba MM, Katz JE, Takahashi TT, Landgraf R, Gross ME, Roberts RW, Kani K. PMID: 29937991; PMCID: PMC6007958.
      View in: PubMed   Mentions: 6     Fields:    
    5. A blood biomarker for monitoring response to anti-EGFR therapy. Cancer Biomark. 2018; 22(2):333-344. Hughes NP, Xu L, Nielsen CH, Chang E, Hori SS, Natarajan A, Lee S, Kjær A, Kani K, Wang SX, Mallick P, Gambhir SS. PMID: 29689709.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    6. Protein Mimetic and Anticancer Properties of Monocyte-Targeting Peptide Amphiphile Micelles. ACS Biomater Sci Eng. 2017 Dec 11; 3(12):3273-3282. Poon C, Chowdhuri S, Kuo CH, Fang Y, Alenghat FJ, Hyatt D, Kani K, Gross ME, Chung EJ. PMID: 29302619; PMCID: PMC5749269.
      View in: PubMed   Mentions: 13     Fields:    
    7. JUN-Mediated Downregulation of EGFR Signaling Is Associated with Resistance to Gefitinib in EGFR-mutant NSCLC Cell Lines. Mol Cancer Ther. 2017 08; 16(8):1645-1657. Kani K, Garri C, Tiemann K, Malihi PD, Punj V, Nguyen AL, Lee J, Hughes LD, Alvarez RM, Wood DM, Joo AY, Katz JE, Agus DB, Mallick P. PMID: 28566434; PMCID: PMC5558834.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    8. Androgen receptor in cancer-associated fibroblasts influences stemness in cancer cells. Endocr Relat Cancer. 2017 04; 24(4):157-170. Liao CP, Chen LY, Luethy A, Kim Y, Kani K, MacLeod AR, Gross ME. PMID: 28264911; PMCID: PMC5453797.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    9. Quantitative Proteomics Using SILAC. Methods Mol Biol. 2017; 1550:171-184. Kani K. PMID: 28188530.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    10. Simulation of the Protein-Shedding Kinetics of a Fully Vascularized Tumor. Cancer Inform. 2015; 14:163-75. Frieboes HB, Curtis LT, Wu M, Kani K, Mallick P. PMID: 26715830; PMCID: PMC4687979.
      View in: PubMed   Mentions: 7  
    11. A cross-platform toolkit for mass spectrometry and proteomics. Nat Biotechnol. 2012 Oct; 30(10):918-20. Chambers MC, Maclean B, Burke R, Amodei D, Ruderman DL, Neumann S, Gatto L, Fischer B, Pratt B, Egertson J, Hoff K, Kessner D, Tasman N, Shulman N, Frewen B, Baker TA, Brusniak MY, Paulse C, Creasy D, Flashner L, Kani K, Moulding C, Seymour SL, Nuwaysir LM, Lefebvre B, Kuhlmann F, Roark J, Rainer P, Detlev S, Hemenway T, Huhmer A, Langridge J, Connolly B, Chadick T, Holly K, Eckels J, Deutsch EW, Moritz RL, Katz JE, Agus DB, MacCoss M, Tabb DL, Mallick P. PMID: 23051804; PMCID: PMC3471674.
      View in: PubMed   Mentions: 1304     Fields:    Translation:Humans
    12. Anterior gradient 2 (AGR2): blood-based biomarker elevated in metastatic prostate cancer associated with the neuroendocrine phenotype. Prostate. 2013 Feb 15; 73(3):306-15. Kani K, Malihi PD, Jiang Y, Wang H, Wang Y, Ruderman DL, Agus DB, Mallick P, Gross ME. PMID: 22911164.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    13. Functional isolation of activated and unilaterally phosphorylated heterodimers of ERBB2 and ERBB3 as scaffolds in ligand-dependent signaling. Proc Natl Acad Sci U S A. 2012 Aug 14; 109(33):13237-42. Zhang Q, Park E, Kani K, Landgraf R. PMID: 22733765; PMCID: PMC3421218.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    14. Quantitative proteomic profiling identifies protein correlates to EGFR kinase inhibition. Mol Cancer Ther. 2012 May; 11(5):1071-81. Kani K, Faca VM, Hughes LD, Zhang W, Fang Q, Shahbaba B, Luethy R, Erde J, Schmidt J, Pitteri SJ, Zhang Q, Katz JE, Gross ME, Plevritis SK, McIntosh MW, Jain A, Hanash S, Agus DB, Mallick P. PMID: 22411897; PMCID: PMC3959865.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    15. Investigation of acquired resistance to EGFR-targeted therapies in lung cancer using cDNA microarrays. Methods Mol Biol. 2012; 795:233-53. Kani K, Sordella R, Mallick P. PMID: 21960227.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    16. Imaging patterns of hepatic steatosis on multidetector CT: pearls and pitfalls. Clin Radiol. 2012 Apr; 67(4):366-71. Kani KK, Moshiri M, Cuevas C, Lee JH, Mitsumori LM, Kolokythas O. PMID: 22000959.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. Impact of protein stability, cellular localization, and abundance on proteomic detection of tumor-derived proteins in plasma. PLoS One. 2011; 6(7):e23090. Fang Q, Kani K, Faca VM, Zhang W, Zhang Q, Jain A, Hanash S, Agus DB, McIntosh MW, Mallick P. PMID: 21829587; PMCID: PMC3146523.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    18. Model-based discovery of circulating biomarkers. Methods Mol Biol. 2011; 728:87-107. Vogelsang MS, Kani K, Katz JE, Mallick P. PMID: 21468942.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    19. Precursor-ion mass re-estimation improves peptide identification on hybrid instruments. J Proteome Res. 2008 Sep; 7(9):4031-9. Luethy R, Kessner DE, Katz JE, Maclean B, Grothe R, Kani K, Faça V, Pitteri S, Hanash S, Agus DB, Mallick P. PMID: 18707148; PMCID: PMC4673049.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    20. The N-terminal domains of neuregulin 1 confer signal attenuation. J Biol Chem. 2006 Sep 15; 281(37):27306-16. Warren CM, Kani K, Landgraf R. PMID: 16825199.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    21. The extracellular domains of ErbB3 retain high ligand binding affinity at endosome pH and in the locked conformation. Biochemistry. 2005 Dec 06; 44(48):15842-57. Kani K, Park E, Landgraf R. PMID: 16313187.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    22. Oligomers of ERBB3 have two distinct interfaces that differ in their sensitivity to disruption by heregulin. J Biol Chem. 2005 Mar 04; 280(9):8238-47. Kani K, Warren CM, Kaddis CS, Loo JA, Landgraf R. PMID: 15611073.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
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