Mitchell E. Gross, MD, PhD
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Title(s) | Associate Professor of Clinical Medicine |
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School | Keck School of Medicine of Usc |
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Address | 12414 Exposition Blvd. Off Campus Los Angeles CA 90064
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Phone | +1 310 272 7640 |
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vCard | Download vCard |
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Biography
| 1989 | | Phi Beta Kappa |
UCSD/Revelle College Academic | 1990 | | Leadership Award |
| 1994 | | Alpha Omega Alpha |
| 1994 | | Hewlett Packard Award for Excellence in Internal Medicine |
| 1997
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| 2002 | Specialty Training Advanced Research Fellowship |
| 1999 | | Amgen Fellowship Research Award |
| 1999 | | Rhone Phoulenc Rorer Travel Award |
| 2001 | | AACR-AFLAC Scholar in Training Award, |
| 2006 | | Donna and Jesse Garber Award |
Overview
Dr. Gross is research director of the USC Norris Westside Cancer Center and the Center for Applied Molecular Medicine. His overall research interest focuses on applying modern techniques relating to the study of genes and proteins (genomics and proteomics) on the clinical problems faced in treating patients with prostate cancer. A particular interest relates to the androgen receptor and relating proteins and pathways as key driving forces behind the development and treatment of prostate cancer. As a medical oncologist, his clinical activities are focused on therapeutic clinical trials incorporating both molecularly targeted and conventional therapies to the care of patients with prostate cancer. He serves as primary investigator on many multi-center phase 1 and 2 clinical trials
Dr. Gross has earned degrees from the University of California, San Diego (B.A.), Baylor College of Medicine in Houston (M.D.), and the University of California, Los Angeles (Ph.D. Molecular Biology). He completed a residency in internal medicine and a fellowship in hematology and medical oncology at the UCLA Center for the Health Sciences.
Research
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Bibliographic
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
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Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
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MRI Detection of Lymph Node Metastasis through Molecular Targeting of C-C Chemokine Receptor Type 2 and Monocyte Hitchhiking. ACS Nano. 2024 Jan 23; 18(3):2091-2104.
Trac N, Chen Z, Oh HS, Jones L, Huang Y, Giblin J, Gross M, Sta Maria NS, Jacobs RE, Chung EJ. PMID: 38212302.
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PubMed Mentions:
1 Fields:
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HumansAnimalsCells
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Cell State and Cell Type: Deconvoluting Circulating Tumor Cell Populations in Liquid Biopsies by Multi-Omics. Cancers (Basel). 2023 Aug 03; 15(15).
Welter L, Zheng S, Setayesh SM, Morikado M, Agrawal A, Nevarez R, Naghdloo A, Pore M, Higa N, Kolatkar A, Thiele JA, Sharma P, Moore HCF, Richer JK, Elias A, Pienta KJ, Zurita AJ, Gross ME, Shishido SN, Hicks J, Velasco CR, Kuhn P. PMID: 37568766; PMCID: PMC10417732.
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Synthesis and anti-cancer potential of potent peripheral MAOA inhibitors designed to limit blood:brain penetration. Bioorg Med Chem. 2023 09 07; 92:117425.
Jacobs MR, Olivero JE, Ok Choi H, Liao CP, Kashemirov BA, Katz JE, Gross ME, McKenna CE. PMID: 37544256.
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PubMed Mentions:
1 Fields:
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HumansCells
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Immune biomarkers associated with COVID-19 disease severity in an urban, hospitalized population. Pract Lab Med. 2023 Aug; 36:e00323.
Chambliss AB, Aljehani M, Tran B, Chen X, Elton E, Garri C, Ung N, Matasci N, Gross ME. PMID: 37649544; PMCID: PMC10462676.
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In Vivo Non-Thermal, Selective Cancer Treatment With High-Frequency Medium-Intensity Focused Ultrasound. IEEE Access. 2021; 9:122051-122066.
Tang Y, Chen LY, Zhang A, Liao CP, Gross ME, Kim ES. PMID: 35321234; PMCID: PMC8939762.
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1
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Effect of Periodized Resistance Training on Skeletal Muscle During Androgen Deprivation Therapy for Prostate Cancer: A Pilot Randomized Trial. Integr Cancer Ther. 2021 Jan-Dec; 20:15347354211035442.
Dawson JK, Dorff TB, Tuzon C, Rice JC, Schroeder ET, Lane CJ, Gross ME, Dieli-Conwright CM. PMID: 34301165; PMCID: PMC8312192.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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CCR2-targeted micelles for anti-cancer peptide delivery and immune stimulation. J Control Release. 2021 01 10; 329:614-623.
Trac N, Chen LY, Zhang A, Liao CP, Poon C, Wang J, Ando Y, Joo J, Garri C, Shen K, Kani K, Gross ME, Chung EJ. PMID: 33011241; PMCID: PMC8491563.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Phase 2 trial of monoamine oxidase inhibitor phenelzine in biochemical recurrent prostate cancer. Prostate Cancer Prostatic Dis. 2021 03; 24(1):61-68.
Gross ME, Agus DB, Dorff TB, Pinski JK, Quinn DI, Castellanos O, Gilmore P, Shih JC. PMID: 32123315; PMCID: PMC7483294.
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PubMed Mentions:
23 Fields:
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HumansCTClinical Trials
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Monitoring dynamic cytotoxic chemotherapy response in castration-resistant prostate cancer using plasma cell-free DNA (cfDNA). BMC Res Notes. 2019 May 15; 12(1):275.
Patsch K, Matasci N, Soundararajan A, Diaz P, Agus DB, Ruderman D, Gross ME. PMID: 31092276; PMCID: PMC6521434.
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13 Fields:
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Humans
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Randomized Phase II Trial of Abiraterone Alone or With Dasatinib in Men With Metastatic Castration-resistant Prostate Cancer (mCRPC). Clin Genitourin Cancer. 2019 08; 17(4):241-247.e1.
Dorff TB, Quinn DI, Pinski JK, Goldkorn A, Sadeghi S, Tsao-Wei D, Groshen S, Kuhn P, Gross ME. PMID: 31227432; PMCID: PMC7446934.
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PubMed Mentions:
7 Fields:
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HumansCellsCTClinical Trials
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Effect of Monoamine oxidase A (MAOA) inhibitors on androgen-sensitive and castration-resistant prostate cancer cells. Prostate. 2019 05; 79(6):667-677.
Gaur S, Gross ME, Liao CP, Qian B, Shih JC. PMID: 30693539; PMCID: PMC7462252.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. Oncogene. 2019 04; 38(16):3003-3018.
Tiemann K, Garri C, Lee SB, Malihi PD, Park M, Alvarez RM, Yap LP, Mallick P, Katz JE, Gross ME, Kani K. PMID: 30575818; PMCID: PMC7523706.
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PubMed Mentions:
21 Fields:
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HumansAnimalsCells
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Identification, characterization and application of a new peptide against anterior gradient homolog 2 (AGR2). Oncotarget. 2018 Jun 08; 9(44):27363-27379.
Garri C, Howell S, Tiemann K, Tiffany A, Jalali-Yazdi F, Alba MM, Katz JE, Takahashi TT, Landgraf R, Gross ME, Roberts RW, Kani K. PMID: 29937991; PMCID: PMC6007958.
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PubMed Mentions:
7 Fields:
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Loss of MAOA in epithelia inhibits adenocarcinoma development, cell proliferation and cancer stem cells in prostate. Oncogene. 2018 09; 37(38):5175-5190.
Liao CP, Lin TP, Li PC, Geary LA, Chen K, Vaikari VP, Wu JB, Lin CH, Gross ME, Shih JC. PMID: 29844571; PMCID: PMC7500062.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Impact of resistance training on body composition and metabolic syndrome variables during androgen deprivation therapy for prostate cancer: a pilot randomized controlled trial. BMC Cancer. 2018 04 03; 18(1):368.
Dawson JK, Dorff TB, Todd Schroeder E, Lane CJ, Gross ME, Dieli-Conwright CM. PMID: 29614993; PMCID: PMC5883585.
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PubMed Mentions:
42 Fields:
Translation:
HumansCTClinical Trials
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Protein Mimetic and Anticancer Properties of Monocyte-Targeting Peptide Amphiphile Micelles. ACS Biomater Sci Eng. 2017 Dec 11; 3(12):3273-3282.
Poon C, Chowdhuri S, Kuo CH, Fang Y, Alenghat FJ, Hyatt D, Kani K, Gross ME, Chung EJ. PMID: 29302619; PMCID: PMC5749269.
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PubMed Mentions:
13 Fields:
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Safety and Efficacy of Docetaxel, Bevacizumab, and Everolimus for Castration-resistant Prostate Cancer (CRPC). Clin Genitourin Cancer. 2017 Jul 14.
Gross ME, Dorff TB, Quinn DI, Diaz PM, Castellanos OO, Agus DB. PMID: 28826933; PMCID: PMC7444943.
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6 Fields:
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A pilot randomised controlled trial of a periodised resistance training and protein supplementation intervention in prostate cancer survivors on androgen deprivation therapy. BMJ Open. 2017 Jul 10; 7(7):e016910.
Kiwata JL, Dorff TB, Todd Schroeder E, Salem GJ, Lane CJ, Rice JC, Gross ME, Dieli-Conwright CM. PMID: 28698349; PMCID: PMC5726104.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Automated analysis of co-localized protein expression in histologic sections of prostate cancer. PLoS One. 2017; 12(5):e0178362.
Tennill TA, Gross ME, Frieboes HB. PMID: 28552967; PMCID: PMC5446169.
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PubMed Mentions:
2 Fields:
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Humans
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Androgen receptor in cancer-associated fibroblasts influences stemness in cancer cells. Endocr Relat Cancer. 2017 04; 24(4):157-170.
Liao CP, Chen LY, Luethy A, Kim Y, Kani K, MacLeod AR, Gross ME. PMID: 28264911; PMCID: PMC5453797.
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19 Fields:
Translation:
HumansAnimalsCells
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A review of clinical effects associated with metabolic syndrome and exercise in prostate cancer patients. Prostate Cancer Prostatic Dis. 2016 12; 19(4):323-332.
Kiwata JL, Dorff TB, Schroeder ET, Gross ME, Dieli-Conwright CM. PMID: 27349496; PMCID: PMC5099103.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimals
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Blood-based gene expression profiling in castrate-resistant prostate cancer. BMC Med. 2015 Sep 14; 13:219.
Gross ME. PMID: 26365516; PMCID: PMC4568585.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Salvage ablative therapy in prostate cancer: international multidisciplinary consensus on trial design. Urol Oncol. 2015 Nov; 33(11):495.e1-7.
van den Bos W, Muller BG, de Bruin DM, de Castro Abreu AL, Chaussy C, Coleman JA, Finelli A, Gill IS, Gross ME, Jenniskens SF, Kahmann F, Laguna-Pes MP, Rastinehad AR, Simmons LA, Sulser T, Villers A, Ward JF, de la Rosette JJ. PMID: 26231310; PMCID: PMC9083830.
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4 Fields:
Translation:
Humans
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Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression. PLoS One. 2015; 10(2):e0117758.
Patel N, Itakura T, Jeong S, Liao CP, Roy-Burman P, Zandi E, Groshen S, Pinski J, Coetzee GA, Gross ME, Fini ME. PMID: 25693195; PMCID: PMC4333349.
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PubMed Mentions:
22 Fields:
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HumansAnimalsCells
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A novel technique using three-dimensionally documented biopsy mapping allows precise re-visiting of prostate cancer foci with serial surveillance of cell cycle progression gene panel. Prostate. 2015 Jun; 75(8):863-71.
Ukimura O, Gross ME, de Castro Abreu AL, Azhar RA, Matsugasumi T, Ushijima S, Kanazawa M, Aron M, Gill IS. PMID: 25663102.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Trans-rectal ultrasound visibility of prostate lesions identified by magnetic resonance imaging increases accuracy of image-fusion targeted biopsies. World J Urol. 2015 Nov; 33(11):1669-76.
Ukimura O, Marien A, Palmer S, Villers A, Aron M, de Castro Abreu AL, Leslie S, Shoji S, Matsugasumi T, Gross M, Dasgupta P, Gill IS. PMID: 25656687; PMCID: PMC9083552.
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20 Fields:
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Humans
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Radium 223: how can we optimize this new tool for metastatic castration-resistant prostate cancer? Am Soc Clin Oncol Educ Book. 2015; e270-3.
Dorff TB, Gross ME. PMID: 25993185.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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A Phase II trial of a combination herbal supplement for men with biochemically recurrent prostate cancer. Prostate Cancer Prostatic Dis. 2014 Dec; 17(4):359-65.
Dorff TB, Groshen S, Tsao-Wei DD, Xiong S, Gross ME, Vogelzang N, Quinn DI, Pinski JK. PMID: 25245366; PMCID: PMC4234307.
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PubMed Mentions:
8 Fields:
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HumansCellsCTClinical Trials
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Rapid phenotypic and genomic change in response to therapeutic pressure in prostate cancer inferred by high content analysis of single circulating tumor cells. PLoS One. 2014; 9(8):e101777.
Dago AE, Stepansky A, Carlsson A, Luttgen M, Kendall J, Baslan T, Kolatkar A, Wigler M, Bethel K, Gross ME, Hicks J, Kuhn P. PMID: 25084170; PMCID: PMC4118839.
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PubMed Mentions:
86 Fields:
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HumansCells
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Intolerance of uncertainty, cognitive complaints, and cancer-related distress in prostate cancer survivors. Psychooncology. 2015 Feb; 24(2):228-35.
Eisenberg SA, Kurita K, Taylor-Ford M, Agus DB, Gross ME, Meyerowitz BE. PMID: 24891013.
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PubMed Mentions:
21 Fields:
Translation:
Humans
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Phase I/II trial of orteronel (TAK-700)--an investigational 17,20-lyase inhibitor--in patients with metastatic castration-resistant prostate cancer. Clin Cancer Res. 2014 Mar 01; 20(5):1335-44.
Dreicer R, MacLean D, Suri A, Stadler WM, Shevrin D, Hart L, MacVicar GR, Hamid O, Hainsworth J, Gross ME, Shi Y, Webb IJ, Agus DB. PMID: 24418642.
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PubMed Mentions:
13 Fields:
Translation:
HumansCTClinical Trials
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Prostate cancer: Age is nothing but a number. Nat Rev Urol. 2013 12; 10(12):683-4.
Gross ME. PMID: 24217679.
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Humans
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Anterior gradient 2 (AGR2): blood-based biomarker elevated in metastatic prostate cancer associated with the neuroendocrine phenotype. Prostate. 2013 Feb 15; 73(3):306-15.
Kani K, Malihi PD, Jiang Y, Wang H, Wang Y, Ruderman DL, Agus DB, Mallick P, Gross ME. PMID: 22911164.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
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Prospective evaluation of 18F-NaF and 18F-FDG PET/CT in detection of occult metastatic disease in biochemical recurrence of prostate cancer. Clin Nucl Med. 2012 Jul; 37(7):637-43.
Jadvar H, Desai B, Ji L, Conti PS, Dorff TB, Groshen SG, Gross ME, Pinski JK, Quinn DI. PMID: 22691503; PMCID: PMC3375600.
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PubMed Mentions:
50 Fields:
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HumansCTClinical Trials
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Safety and preliminary efficacy analysis of the mTOR inhibitor ridaforolimus in patients with taxane-treated, castration-resistant prostate cancer. Clin Genitourin Cancer. 2012 Dec; 10(4):232-8.
Amato RJ, Wilding G, Bubley G, Loewy J, Haluska F, Gross ME. PMID: 22695254; PMCID: PMC3963491.
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PubMed Mentions:
12 Fields:
Translation:
HumansCTClinical Trials
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Multimodality imaging in biochemical recurrence of prostate cancer: utility of (18)F-NaF PET/CT in early detection of metastasis. Rev Esp Med Nucl Imagen Mol. 2012 Jul-Aug; 31(4):231-2.
Desai B, Gross ME, Jadvar H. PMID: 22980132; PMCID: PMC3458514.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Focal cryotherapy for clinically unilateral, low-intermediate risk prostate cancer in 73 men with a median follow-up of 3.7 years. Eur Urol. 2012 Jul; 62(1):55-63.
Bahn D, de Castro Abreu AL, Gill IS, Hung AJ, Silverman P, Gross ME, Lieskovsky G, Ukimura O. PMID: 22445223.
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PubMed Mentions:
66 Fields:
Translation:
Humans
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Body image predicts quality of life in men with prostate cancer. Psychooncology. 2013 Apr; 22(4):756-61.
Taylor-Ford M, Meyerowitz BE, D'Orazio LM, Christie KM, Gross ME, Agus DB. PMID: 22422671.
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PubMed Mentions:
15 Fields:
Translation:
Humans
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Quantitative proteomic profiling identifies protein correlates to EGFR kinase inhibition. Mol Cancer Ther. 2012 May; 11(5):1071-81.
Kani K, Faca VM, Hughes LD, Zhang W, Fang Q, Shahbaba B, Luethy R, Erde J, Schmidt J, Pitteri SJ, Zhang Q, Katz JE, Gross ME, Plevritis SK, McIntosh MW, Jain A, Hanash S, Agus DB, Mallick P. PMID: 22411897; PMCID: PMC3959865.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Cytometric comparisons between circulating tumor cells from prostate cancer patients and the prostate-tumor-derived LNCaP cell line. Phys Biol. 2012 Feb; 9(1):016002.
Lazar DC, Cho EH, Luttgen MS, Metzner TJ, Uson ML, Torrey M, Gross ME, Kuhn P. PMID: 22306736; PMCID: PMC3387997.
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PubMed Mentions:
34 Fields:
Translation:
HumansCells
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3-Dimensional elastic registration system of prostate biopsy location by real-time 3-dimensional transrectal ultrasound guidance with magnetic resonance/transrectal ultrasound image fusion. J Urol. 2012 Mar; 187(3):1080-6.
Ukimura O, Desai MM, Palmer S, Valencerina S, Gross M, Abreu AL, Aron M, Gill IS. PMID: 22266005.
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55 Fields:
Translation:
Humans
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Safety and pharmacokinetics of high-dose gefitinib in patients with solid tumors: results of a phase I study. Cancer Chemother Pharmacol. 2012 Jan; 69(1):273-80.
Gross ME, Leichman L, Lowe ES, Swaisland A, Agus DB. PMID: 22002543.
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PubMed Mentions:
4 Fields:
Translation:
HumansCTClinical Trials
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The epothilones: new therapeutic agents for castration-resistant prostate cancer. Oncologist. 2011; 16(10):1349-58.
Dorff TB, Gross ME. PMID: 21964003; PMCID: PMC3228074.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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Once-daily dasatinib: expansion of phase II study evaluating safety and efficacy of dasatinib in patients with metastatic castration-resistant prostate cancer. Urology. 2011 May; 77(5):1166-71.
Yu EY, Massard C, Gross ME, Carducci MA, Culine S, Hudes G, Posadas EM, Sternberg CN, Wilding G, Trudel GC, Paliwal P, Fizazi K. PMID: 21539969; PMCID: PMC3394099.
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PubMed Mentions:
44 Fields:
Translation:
HumansCTClinical Trials
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Show us a sign: the search for "game changing" prostate cancer biomarkers. Lancet Oncol. 2011 Mar; 12(3):204-6.
Quinn D, Gross M. PMID: 21310657.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Beta-2-microglobulin expression correlates with high-grade prostate cancer and specific defects in androgen signaling. Prostate. 2010 Aug; 70(11):1201-10.
Mink SR, Hodge A, Agus DB, Jain A, Gross ME. PMID: 20564426.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Detection of androgen receptor mutations in circulating tumor cells in castration-resistant prostate cancer. Clin Chem. 2010 Sep; 56(9):1492-5.
Jiang Y, Palma JF, Agus DB, Wang Y, Gross ME. PMID: 20581083.
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PubMed Mentions:
55 Fields:
Translation:
HumansCells
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Cilengitide (EMD 121974, NSC 707544) in asymptomatic metastatic castration resistant prostate cancer patients: a randomized phase II trial by the prostate cancer clinical trials consortium. Invest New Drugs. 2011 Dec; 29(6):1432-40.
Bradley DA, Daignault S, Ryan CJ, Dipaola RS, Cooney KA, Smith DC, Small E, Mathew P, Gross ME, Stein MN, Chen A, Pienta KJ, Escara-Wilke J, Doyle G, Al-Hawary M, Keller ET, Hussain M. PMID: 20336348; PMCID: PMC2917503.
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26 Fields:
Translation:
HumansCellsCTClinical Trials
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Predictors of affect following treatment decision-making for prostate cancer: conversations, cognitive processing, and coping. Psychooncology. 2009 May; 18(5):508-14.
Christie KM, Meyerowitz BE, Giedzinska-Simons A, Gross M, Agus DB. PMID: 18756584.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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Rare mutations of the PIK3CA gene in malignancies of the hematopoietic system as well as endometrium, ovary, prostate and osteosarcomas, and discovery of a PIK3CA pseudogene. Leuk Res. 2007 Jan; 31(1):27-32.
Müller CI, Miller CW, Hofmann WK, Gross ME, Walsh CS, Kawamata N, Luong QT, Koeffler HP. PMID: 16764926.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Ductal adenocarcinoma of the prostate. Clin Adv Hematol Oncol. 2004 Jun; 2(6):393-5; discussion 396.
Shazer RL, Luthringer D, Agus DB, Gross ME. PMID: 16163211.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Targeting the HER-kinase axis in cancer. Semin Oncol. 2004 Feb; 31(1 Suppl 3):9-20.
Gross ME, Shazer RL, Agus DB. PMID: 15052539.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Update on HER-kinase-directed therapy in prostate cancer. Clin Adv Hematol Oncol. 2004 Jan; 2(1):53-6, 64.
Gross ME, Jo S, Agus DB. PMID: 16163160.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCells
This graph shows the total number of publications by year. To see the data as text,
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This graph shows the total number of publications by year. To return to the graph,
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Year | Publications |
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2004 | 3 |
2006 | 1 |
2009 | 1 |
2010 | 3 |
2011 | 4 |
2012 | 9 |
2013 | 1 |
2014 | 4 |
2015 | 6 |
2016 | 1 |
2017 | 5 |
2018 | 4 |
2019 | 3 |
2020 | 2 |
2021 | 2 |
2023 | 3 |
2024 | 1 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
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