Loading...

Judd Christopher Rice, PhD

Title(s)Associate Professor of Biochemistry & Molecular Medicine
AddressNRT 6506 1450 Biggy Street
Health Sciences Campus
Los Angeles CA 90089
Phone+1 323 442 4332
vCardDownload vCard
    Other Positions
    Title(s)Director, Biochemistry & Molecular Medicine Master's Degree Program


    Collapse Overview 
    Collapse Overview
    Each human chromosome contains 50-250 x 10e6 base pairs of DNA that compacts into an orderly structure by interacting with chromosomal proteins. Together, the DNA and these chromosomal proteins are generically described as chromatin. In eukaryotic organisms, the ability to precisely regulate nuclear processes is hindered by the inherently repressive chromatin environment where DNA is tightly packaged with chromosomal proteins. The fundamental structural unit of chromatin is the nucleosome which consists of the core histone octamer (two each of histone proteins H2A, H2B, H3 and H4) and the associated 146 base pairs of DNA that wraps twice around them. The N-terminal "tails" of the histones protrude from the nucleosome to interact with the nuclear environment. The enzymatic addition or removal of various post-translational modifications on histones generates a "histone code" at specific genomic regions that directly function to regulate specific DNA-templated processes including transcription, replication, repair, recombination and chromosome structure. Importantly, the activities of chromatin-modifying proteins are frequently altered in many human pathologies including developmental and age-related diseases, such as cancer.

    The overall goal of my lab is to elucidate the factors that establish and maintain the "histone code" and how their concerted functions regulate essential chromatin-dependent events including transcription, DNA replication and DNA repair. This is accomplished using a combination of conventional biochemical approaches and state-of-the-art technologies. Our long term goal is to translate these fundamental biological insights into novel epigenetic therapies for the treatment of human diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    Histone Proteolysis as a Novel Regulator of Myogenic Activation
    NIH/NIAMS R21AR074649Dec 1, 2018 - Nov 30, 2020
    Role: Principal Investigator
    Molecular mechanisms of gene silencing by H4 methylation
    NIH/NIGMS R01GM075094Aug 1, 2007 - Jul 31, 2012
    Role: Principal Investigator
    Epigenetic silencing by histone methylation
    NIH/NIGMS F32GM064279Jun 25, 2001 - Oct 31, 2003
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A pilot randomised controlled trial of a periodised resistance training and protein supplementation intervention in prostate cancer survivors on androgen deprivation therapy. BMJ Open. 2017 Jul 10; 7(7):e016910. Kiwata JL, Dorff TB, Todd Schroeder E, Salem GJ, Lane CJ, Rice JC, Gross ME, Dieli-Conwright CM. PMID: 28698349.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    2. The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Nat Chem Biol. 2017 03; 13(3):317-324. Bromberg KD, Mitchell TR, Upadhyay AK, Jakob CG, Jhala MA, Comess KM, Lasko LM, Li C, Tuzon CT, Dai Y, Li F, Eram MS, Nuber A, Soni NB, Manaves V, Algire MA, Sweis RF, Torrent M, Schotta G, Sun C, Michaelides MR, Shoemaker AR, Arrowsmith CH, Brown PJ, Santhakumar V, Martin A, Rice JC, Chiang GG, Vedadi M, Barsyte-Lovejoy D, Pappano WN. PMID: 28114273.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    3. Acute Response of PGC-1a and IGF-1 Isoforms to Maximal Eccentric Exercise in Skeletal Muscle of Postmenopausal Women. J Strength Cond Res. 2016 Apr; 30(4):1161-70. Dieli-Conwright CM, Kiwata JL, Tuzon CT, Spektor TM, Sattler FR, Rice JC, Schroeder ET. PMID: 26340467.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    4. MMP-9 facilitates selective proteolysis of the histone H3 tail at genes necessary for proficient osteoclastogenesis. Genes Dev. 2016 Jan 15; 30(2):208-19. Kim K, Punj V, Kim JM, Lee S, Ulmer TS, Lu W, Rice JC, An W. PMID: 26744418.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    5. Cooperation between SMYD3 and PC4 drives a distinct transcriptional program in cancer cells. Nucleic Acids Res. 2015 Oct 15; 43(18):8868-83. Kim JM, Kim K, Schmidt T, Punj V, Tucker H, Rice JC, Ulmer TS, An W. PMID: 26350217.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    6. Small-molecule inhibitors of SETD8 with cellular activity. ACS Chem Biol. 2014 Nov 21; 9(11):2471-8. Blum G, Ibáñez G, Rao X, Shum D, Radu C, Djaballah H, Rice JC, Luo M. PMID: 25137013.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    7. Concerted activities of distinct H4K20 methyltransferases at DNA double-strand breaks regulate 53BP1 nucleation and NHEJ-directed repair. Cell Rep. 2014 Jul 24; 8(2):430-8. Tuzon CT, Spektor T, Kong X, Congdon LM, Wu S, Schotta G, Yokomori K, Rice JC. PMID: 25001286.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    8. Bent bone dysplasia syndrome reveals nucleolar activity for FGFR2 in ribosomal DNA transcription. Hum Mol Genet. 2014 Nov 01; 23(21):5659-71. Neben CL, Idoni B, Salva JE, Tuzon CT, Rice JC, Krakow D, Merrill AE. PMID: 24908667.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    9. The PR-Set7 binding domain of Riz1 is required for the H4K20me1-H3K9me1 trans-tail 'histone code' and Riz1 tumor suppressor function. Nucleic Acids Res. 2014 Apr; 42(6):3580-9. Congdon LM, Sims JK, Tuzon CT, Rice JC. PMID: 24423864.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    10. Identification and characterization of functional risk variants for colorectal cancer mapping to chromosome 11q23.1. Hum Mol Genet. 2014 Apr 15; 23(8):2198-209. Biancolella M, Fortini BK, Tring S, Plummer SJ, Mendoza-Fandino GA, Hartiala J, Hitchler MJ, Yan C, Schumacher FR, Conti DV, Edlund CK, Noushmehr H, Coetzee SG, Bresalier RS, Ahnen DJ, Barry EL, Berman BP, Rice JC, Coetzee GA, Casey G. PMID: 24256810.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    11. Proteomic and functional analyses reveal the role of chromatin reader SFMBT1 in regulating epigenetic silencing and the myogenic gene program. J Biol Chem. 2013 Mar 01; 288(9):6238-47. Lin S, Shen H, Li JL, Tang S, Gu Y, Chen Z, Hu C, Rice JC, Lu J, Wu L. PMID: 23349461.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    12. Hormone therapy and maximal eccentric exercise alters myostatin-related gene expression in postmenopausal women. J Strength Cond Res. 2012 May; 26(5):1374-82. Dieli-Conwright CM, Spektor TM, Rice JC, Sattler FR, Schroeder ET. PMID: 22395277.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    13. Genome-wide evaluation of histone methylation changes associated with leaf senescence in Arabidopsis. PLoS One. 2012; 7(3):e33151. Brusslan JA, Rus Alvarez-Canterbury AM, Nair NU, Rice JC, Hitchler MJ, Pellegrini M. PMID: 22427974.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    14. The UBC9 E2 SUMO conjugating enzyme binds the PR-Set7 histone methyltransferase to facilitate target gene repression. PLoS One. 2011; 6(7):e22785. Spektor TM, Congdon LM, Veerappan CS, Rice JC. PMID: 21829513.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    15. A new regulator of the cell cycle: the PR-Set7 histone methyltransferase. . 2011 Jan 01; 10(1):68-72. Wu S, Rice JC. PMID: 21200139.
      View in: PubMed   Mentions:
    16. Genome-wide epigenetic analysis of human pluripotent stem cells by ChIP and ChIP-Seq. Methods Mol Biol. 2011; 767:253-67. Hitchler MJ, Rice JC. PMID: 21822881.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    17. Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression. Genes Dev. 2010 Nov 15; 24(22):2531-42. Wu S, Wang W, Kong X, Congdon LM, Yokomori K, Kirschner MW, Rice JC. PMID: 20966048.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    18. Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function. Proc Natl Acad Sci U S A. 2010 Sep 28; 107(39):16952-7. Lucio-Eterovic AK, Singh MM, Gardner JE, Veerappan CS, Rice JC, Carpenter PB. PMID: 20837538.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    19. PR-Set7-mediated monomethylation of histone H4 lysine 20 at specific genomic regions induces transcriptional repression. J Cell Biochem. 2010 Jun 01; 110(3):609-19. Congdon LM, Houston SI, Veerappan CS, Spektor TM, Rice JC. PMID: 20512922.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    20. A histone methylation code for SV40 minichromosomes. . 2010 Apr 01; 9(7):1235-6. Wu S, Rice JC. PMID: 20404522.
      View in: PubMed   Mentions:
    21. Hormone replacement therapy and messenger RNA expression of estrogen receptor coregulators after exercise in postmenopausal women. Med Sci Sports Exerc. 2010 Mar; 42(3):422-9. Dieli-Conwright CM, Spektor TM, Rice JC, Sattler FR, Schroeder ET. PMID: 20164697.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Exercise does not influence myostatin and follistatin messenger RNA expression in young women. J Strength Cond Res. 2010 Feb; 24(2):522-30. Jensky NE, Sims JK, Dieli-Conwright CM, Sattler FR, Rice JC, Schroeder ET. PMID: 20124796.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    23. Influence of hormone replacement therapy on eccentric exercise induced myogenic gene expression in postmenopausal women. J Appl Physiol (1985). 2009 Nov; 107(5):1381-8. Dieli-Conwright CM, Spektor TM, Rice JC, Sattler FR, Schroeder ET. PMID: 19696363.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    24. Identification and characterization of posttranslational modification-specific binding proteins in vivo by mammalian tethered catalysis. Proc Natl Acad Sci U S A. 2009 Sep 01; 106(35):14808-13. Spektor TM, Rice JC. PMID: 19706462.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    25. Hormone therapy attenuates exercise-induced skeletal muscle damage in postmenopausal women. J Appl Physiol (1985). 2009 Sep; 107(3):853-8. Dieli-Conwright CM, Spektor TM, Rice JC, Sattler FR, Schroeder ET. PMID: 19574506.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    26. Catalytic function of the PR-Set7 histone H4 lysine 20 monomethyltransferase is essential for mitotic entry and genomic stability. J Biol Chem. 2008 Jul 11; 283(28):19478-88. Houston SI, McManus KJ, Adams MM, Sims JK, Carpenter PB, Hendzel MJ, Rice JC. PMID: 18480059.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    27. PR-Set7 establishes a repressive trans-tail histone code that regulates differentiation. Mol Cell Biol. 2008 Jul; 28(14):4459-68. Sims JK, Rice JC. PMID: 18474616.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    28. Ring around the genes. Nat Cell Biol. 2007 Dec; 9(12):1343-4. Spektor TM, Rice JC. PMID: 18059356.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    29. The influence of eccentric exercise on mRNA expression of skeletal muscle regulators. Eur J Appl Physiol. 2007 Nov; 101(4):473-80. Jensky NE, Sims JK, Rice JC, Dreyer HC, Schroeder ET. PMID: 17661068.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    30. Human SFMBT is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3. FEBS Lett. 2007 Jul 10; 581(17):3289-96. Wu S, Trievel RC, Rice JC. PMID: 17599839.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    31. A trans-tail histone code defined by monomethylated H4 Lys-20 and H3 Lys-9 demarcates distinct regions of silent chromatin. J Biol Chem. 2006 May 05; 281(18):12760-6. Sims JK, Houston SI, Magazinnik T, Rice JC. PMID: 16517599.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    32. Regulation of heterochromatin by histone methylation and small RNAs. Curr Opin Cell Biol. 2004 Jun; 16(3):230-8. Grewal SI, Rice JC. PMID: 15145346.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    33. Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains. Mol Cell. 2003 Dec; 12(6):1591-8. Rice JC, Briggs SD, Ueberheide B, Barber CM, Shabanowitz J, Hunt DF, Shinkai Y, Allis CD. PMID: 14690610.
      View in: PubMed   Mentions: 284     Fields:    Translation:HumansAnimalsCells
    34. Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. Genes Dev. 2002 Sep 01; 16(17):2225-30. Rice JC, Nishioka K, Sarma K, Steward R, Reinberg D, Allis CD. PMID: 12208845.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansCells
    35. PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol Cell. 2002 Jun; 9(6):1201-13. Nishioka K, Rice JC, Sarma K, Erdjument-Bromage H, Werner J, Wang Y, Chuikov S, Valenzuela P, Tempst P, Steward R, Lis JT, Allis CD, Reinberg D. PMID: 12086618.
      View in: PubMed   Mentions: 218     Fields:    Translation:HumansAnimalsCells
    Judd's Networks
    Concepts (229)
    Derived automatically from this person's publications.
    _
    Co-Authors (11)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _