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Pin Wang, PhD

Title(s)Professor
SchoolViterbi School of Engineering, BME
Phone+1 213 740 0780
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    Collapse Overview 
    Collapse Overview
    The Wang laboratory focuses on an emerging field of “immunobioengineering” with the aim of employing engineering tools and principles to quantitatively understand the immune system in health and disease and to develop novel molecular and cellular immunotherapies by precisely modulating disease-specific immune responses. The ongoing research research projects include: 1) exploring various strategies to engineer virus-derived vector systems for dendritic cell-targeted vaccine delivery and oncolytic virus-based immunotherapy; 2) designing and optimizing cellular immunotherapy that is based on molecular engineering of chimeric antigen receptors (CARs); 3) exploring immune cells as drug carriers for targeted delivery of immunomodulatory drugs to enhance cancer immunotherapy; 4) exploring systems biology tools for modeling and understanding details of signaling pathways mediated by designer molecules such as chimeric antigen receptors to activate T cells; 5) developing engineering methods to improve adeno-associated virus (AAV)-based gene delivery. In this research laboratory, bioengineers collaborate with chemists, immunologists, computer scientists, and system biologists to directly address problems in translational immunology and develop and optimize innovative approaches to improve lives of patients suffering from cancer and infectious diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    In situ Redirection of T cell Specificity and Imaging of Targeted CAR Expression.
    NIH/NIBIB R01EB017206Sep 1, 2013 - Aug 31, 2017
    Role: Co-Principal Investigator
    SUPR Peptides to Inhibit Undruggable Cancer Target (PQ18)
    NIH/NCI R01CA170820Sep 17, 2012 - Jun 30, 2016
    Role: Co-Principal Investigator
    Targeting lentiviruses to infect chosen cells
    NIH/NIAID R01AI068978Feb 1, 2006 - Jan 31, 2012
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rohrs JA, Zheng D, Graham NA, Wang P, Finley SD. Computational Model of Chimeric Antigen Receptors Explains Site-Specific Phosphorylation Kinetics. Biophys J. 2018 Sep 18; 115(6):1116-1129. PMID: 30197180.
      View in: PubMed
    2. Siegler EL, Zhu Y, Wang P, Yang L. Off-the-Shelf CAR-NK Cells for Cancer Immunotherapy. Cell Stem Cell. 2018 Aug 02; 23(2):160-161. PMID: 30075127.
      View in: PubMed
    3. Iriondo O, Liu Y, Lee G, Elhodaky M, Jimenez C, Li L, Lang J, Wang P, Yu M. TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis. Nat Commun. 2018 05 18; 9(1):1994. PMID: 29777109.
      View in: PubMed
    4. Siriwon N, Kim YJ, Siegler E, Chen X, Rohrs JA, Liu Y, Wang P. CAR-T Cells Surface-Engineered with Drug-Encapsulated Nanoparticles Can Ameliorate Intratumoral T-cell Hypofunction. Cancer Immunol Res. 2018 Jul; 6(7):812-824. PMID: 29720380.
      View in: PubMed
    5. Siegler EL, Wang P. Preclinical Models in Chimeric Antigen Receptor-Engineered T-Cell Therapy. Hum Gene Ther. 2018 May; 29(5):534-546. PMID: 29390873.
      View in: PubMed
    6. Cheng Z, Wei R, Ma Q, Shi L, He F, Shi Z, Jin T, Xie R, Wei B, Chen J, Fang H, Han X, Rohrs JA, Bryson P, Liu Y, Li QJ, Zhu B, Wang P. In Vivo Expansion and Antitumor Activity of Coinfused CD28- and 4-1BB-Engineered CAR-T Cells in Patients with B Cell Leukemia. Mol Ther. 2018 04 04; 26(4):976-985. PMID: 29503204.
      View in: PubMed
    7. Li S, Siriwon N, Zhang X, Yang S, Jin T, He F, Kim YJ, Mac J, Lu Z, Wang S, Han X, Wang P. Enhanced Cancer Immunotherapy by Chimeric Antigen Receptor-Modified T Cells Engineered to Secrete Checkpoint Inhibitors. Clin Cancer Res. 2017 Nov 15; 23(22):6982-6992. PMID: 28912137.
      View in: PubMed
    8. Bryson PD, Han X, Truong N, Wang P. Breast cancer vaccines delivered by dendritic cell-targeted lentivectors induce potent antitumor immune responses and protect mice from mammary tumor growth. Vaccine. 2017 10 13; 35(43):5842-5849. PMID: 28916248.
      View in: PubMed
    9. Siegler EL, Kim YJ, Chen X, Siriwon N, Mac J, Rohrs JA, Bryson PD, Wang P. Combination Cancer Therapy Using Chimeric Antigen Receptor-Engineered Natural Killer Cells as Drug Carriers. Mol Ther. 2017 Dec 06; 25(12):2607-2619. PMID: 28919377.
      View in: PubMed
    10. Kim JT, Liu Y, Kulkarni RP, Lee KK, Dai B, Lovely G, Ouyang Y, Wang P, Yang L, Baltimore D. Dendritic cell-targeted lentiviral vector immunization uses pseudotransduction and DNA-mediated STING and cGAS activation. Sci Immunol. 2017 Jul 21; 2(13). PMID: 28733470.
      View in: PubMed
    11. Han X, Cinay GE, Zhao Y, Guo Y, Zhang X, Wang P. Adnectin-Based Design of Chimeric Antigen Receptor for T Cell Engineering. Mol Ther. 2017 11 01; 25(11):2466-2476. PMID: 28784559.
      View in: PubMed
    12. Siegler E, Li S, Kim YJ, Wang P. Designed Ankyrin Repeat Proteins as Her2 Targeting Domains in Chimeric Antigen Receptor-Engineered T Cells. Hum Gene Ther. 2017 09; 28(9):726-736. PMID: 28796529.
      View in: PubMed
    13. Zhang X, Liu Y, Kim YJ, Mac J, Zhuang R, Wang P. Co-delivery of carboplatin and paclitaxel via cross-linked multilamellar liposomes for ovarian cancer treatment. RSC Adv. 2017 Apr 03; 7(32):19685-19693. PMID: 28603607.
      View in: PubMed
    14. Han X, Bryson PD, Zhao Y, Cinay GE, Li S, Guo Y, Siriwon N, Wang P. Masked Chimeric Antigen Receptor for Tumor-Specific Activation. Mol Ther. 2017 01 04; 25(1):274-284. PMID: 28129121.
      View in: PubMed
    15. Fiacco SV, Kelderhouse LE, Hardy A, Peleg Y, Hu B, Ornelas A, Yang P, Gammon ST, Howell SM, Wang P, Takahashi TT, Millward SW, Roberts RW. Directed Evolution of Scanning Unnatural-Protease-Resistant (SUPR) Peptides for in Vivo Applications. Chembiochem. 2016 09 02; 17(17):1643-51. PMID: 27465925.
      View in: PubMed
    16. Rohrs JA, Wang P, Finley SD. Predictive Model of Lymphocyte-Specific Protein Tyrosine Kinase (LCK) Autoregulation. Cell Mol Bioeng. 2016; 9:351-367. PMID: 27547268.
      View in: PubMed
    17. Fang J, Hu B, Li S, Zhang C, Liu Y, Wang P. A multi-antigen vaccine in combination with an immunotoxin targeting tumor-associated fibroblast for treating murine melanoma. Mol Ther Oncolytics. 2016; 3:16007. PMID: 27119119; PMCID: PMC4824564.
      View in: PubMed, PubMed Central
    18. Nigam N, Grover A, Goyal S, Katiyar SP, Bhargava P, Wang PC, Sundar D, Kaul SC, Wadhwa R. Targeting Mortalin by Embelin Causes Activation of Tumor Suppressor p53 and Deactivation of Metastatic Signaling in Human Breast Cancer Cells. PLoS One. 2015; 10(9):e0138192. PMID: 26376435; PMCID: PMC4574062.
      View in: PubMed, PubMed Central
    19. Fang J, Xiao L, Joo KI, Liu Y, Zhang C, Liu S, Conti PS, Li Z, Wang P. A potent immunotoxin targeting fibroblast activation protein for treatment of breast cancer in mice. Int J Cancer. 2016 Feb 15; 138(4):1013-23. PMID: 26334777; PMCID: PMC4715643 [Available on 02/15/17].
      View in: PubMed, PubMed Central
    20. Noguchi TK, Ninomiya N, Sekine M, Komazaki S, Wang PC, Asashima M, Kurisaki A. Generation of stomach tissue from mouse embryonic stem cells. Nat Cell Biol. 2015 Aug; 17(8):984-93. PMID: 26192439.
      View in: PubMed
    21. Kim YJ, Liu Y, Li S, Rohrs J, Zhang R, Zhang X, Wang P. Co-Eradication of Breast Cancer Cells and Cancer Stem Cells by Cross-Linked Multilamellar Liposomes Enhances Tumor Treatment. Mol Pharm. 2015 Aug 03; 12(8):2811-22. PMID: 26098197.
      View in: PubMed
    22. Liu Y, Siriwon N, Rohrs JA, Wang P. Generation of Targeted Adeno-Associated Virus (AAV) Vectors for Human Gene Therapy. Curr Pharm Des. 2015; 21(22):3248-56. PMID: 26027561.
      View in: PubMed
    23. Zhang C, Hu B, Xiao L, Liu Y, Wang P. Pseudotyping lentiviral vectors with lymphocytic choriomeningitis virus glycoproteins for transduction of dendritic cells and in vivo immunization. Hum Gene Ther Methods. 2014 Dec; 25(6):328-38. PMID: 25416034; PMCID: PMC4268581.
      View in: PubMed, PubMed Central
    24. Liu Y, Fang J, Joo KI, Wong MK, Wang P. Codelivery of chemotherapeutics via crosslinked multilamellar liposomal vesicles to overcome multidrug resistance in tumor. PLoS One. 2014; 9(10):e110611. PMID: 25330237.
      View in: PubMed
    25. Zhao M, Liu Y, Hsieh RS, Wang N, Tai W, Joo KI, Wang P, Gu Z, Tang Y. Clickable protein nanocapsules for targeted delivery of recombinant p53 protein. J Am Chem Soc. 2014 Oct 29; 136(43):15319-25. PMID: 25289975.
      View in: PubMed
    26. Liu Y, Xiao L, Joo KI, Hu B, Fang J, Wang P. In situ modulation of dendritic cells by injectable thermosensitive hydrogels for cancer vaccines in mice. Biomacromolecules. 2014 Oct 13; 15(10):3836-45. PMID: 25207465; PMCID: PMC4195289.
      View in: PubMed, PubMed Central
    27. Howell SM, Fiacco SV, Takahashi TT, Jalali-Yazdi F, Millward SW, Hu B, Wang P, Roberts RW. Serum stable natural peptides designed by mRNA display. Sci Rep. 2014 Sep 19; 4:6008. PMID: 25234472; PMCID: PMC4168267.
      View in: PubMed, PubMed Central
    28. Kowno M, Watanabe-Susaki K, Ishimine H, Komazaki S, Enomoto K, Seki Y, Wang YY, Ishigaki Y, Ninomiya N, Noguchi TA, Kokubu Y, Ohnishi K, Nakajima Y, Kato K, Intoh A, Takada H, Yamakawa N, Wang PC, Asashima M, Kurisaki A. Prohibitin 2 regulates the proliferation and lineage-specific differentiation of mouse embryonic stem cells in mitochondria. PLoS One. 2014; 9(4):e81552. PMID: 24709813; PMCID: PMC3977857.
      View in: PubMed, PubMed Central
    29. Liu Y, Fang J, Kim YJ, Wong MK, Wang P. Codelivery of doxorubicin and paclitaxel by cross-linked multilamellar liposome enables synergistic antitumor activity. Mol Pharm. 2014 May 05; 11(5):1651-61. PMID: 24673622; PMCID: PMC4018157.
      View in: PubMed, PubMed Central
    30. Liu Y, Kim YJ, Ji M, Fang J, Siriwon N, Zhang LI, Wang P. Enhancing gene delivery of adeno-associated viruses by cell-permeable peptides. Mol Ther Methods Clin Dev. 2014; 1:12. PMID: 26015948; PMCID: PMC4365833.
      View in: PubMed, PubMed Central
    31. Yang L, Wang P. Passive immunization against HIV/AIDS by antibody gene transfer. Viruses. 2014 Jan 27; 6(2):428-47. PMID: 24473340; PMCID: PMC3939464.
      View in: PubMed, PubMed Central
    32. Liu Y, Joo KI, Lei Y, Wang P. Visualization of intracellular pathways of engineered baculovirus in mammalian cells. Virus Res. 2014 Mar 06; 181:81-91. PMID: 24457070; PMCID: PMC4439417.
      View in: PubMed, PubMed Central
    33. Liu Y, Rohrs J, Wang P. Advances and challenges in the use of nanoparticles to optimize PK/PD interactions of combined anti-cancer therapies. Curr Drug Metab. 2014; 15(8):818-28. PMID: 25705903.
      View in: PubMed
    34. Liu Y, Fox V, Lei Y, Hu B, Joo KI, Wang P. Synthetic niches for differentiation of human embryonic stem cells bypassing embryoid body formation. J Biomed Mater Res B Appl Biomater. 2014 Jul; 102(5):1101-12. PMID: 24327412.
      View in: PubMed
    35. Hsu HH, Murasawa Y, Qi P, Nishimura Y, Wang PC. Type V collagen fibrils in mouse metanephroi. Biochem Biophys Res Commun. 2013 Nov 22; 441(3):649-54. PMID: 24404584.
      View in: PubMed
    36. Hsu HH, Murasawa Y, Qi P, Nishimura Y, Wang PC. Type V Collagen Fibrils in Mouse Metanephroi. Biochem Biophys Res Commun. 2013 Oct 26. PMID: 24513214.
      View in: PubMed
    37. Liu Y, Tai A, Joo KI, Wang P. Visualization of DC-SIGN-mediated entry pathway of engineered lentiviral vectors in target cells. PLoS One. 2013; 8(6):e67400. PMID: 23840690; PMCID: PMC3696072.
      View in: PubMed, PubMed Central
    38. Bryson PD, Zhang C, Lee CL, Wang P. A tetracycline-regulated cell line produces high-titer lentiviral vectors that specifically target dendritic cells. J Vis Exp. 2013 Jun 19; (76). PMID: 23851977; PMCID: PMC3727697.
      View in: PubMed, PubMed Central
    39. Liu Y, Ji M, Wong MK, Joo KI, Wang P. Enhanced therapeutic efficacy of iRGD-conjugated crosslinked multilayer liposomes for drug delivery. Biomed Res Int. 2013; 2013:378380. PMID: 23691500; PMCID: PMC3652104.
      View in: PubMed, PubMed Central
    40. Xiao L, Hung KC, Takahashi TT, Joo KI, Lim M, Roberts RW, Wang P. Antibody-mimetic ligand selected by mRNA display targets DC-SIGN for dendritic cell-directed antigen delivery. ACS Chem Biol. 2013 May 17; 8(5):967-77. PMID: 23427768.
      View in: PubMed
    41. Chooi YH, Fang J, Liu H, Filler SG, Wang P, Tang Y. Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi. Org Lett. 2013 Feb 15; 15(4):780-3. PMID: 23368997; PMCID: PMC3576815.
      View in: PubMed, PubMed Central
    42. Joo KI, Xiao L, Liu S, Liu Y, Lee CL, Conti PS, Wong MK, Li Z, Wang P. Crosslinked multilamellar liposomes for controlled delivery of anticancer drugs. Biomaterials. 2013 Apr; 34(12):3098-109. PMID: 23375392; PMCID: PMC3995748.
      View in: PubMed, PubMed Central
    43. Xiao L, Joo KI, Lim M, Wang P. Dendritic cell-directed vaccination with a lentivector encoding PSCA for prostate cancer in mice. PLoS One. 2012; 7(11):e48866. PMID: 23139820; PMCID: PMC3490948.
      View in: PubMed, PubMed Central
    44. Liu Y, Fang Y, Zhou Y, Zandi E, Lee CL, Joo KI, Wang P. Site-specific modification of adeno-associated viruses via a genetically engineered aldehyde tag. Small. 2013 Feb 11; 9(3):421-9. PMID: 23038676.
      View in: PubMed
    45. Chooi YH, Wang P, Fang J, Li Y, Wu K, Wang P, Tang Y. Discovery and characterization of a group of fungal polycyclic polyketide prenyltransferases. J Am Chem Soc. 2012 Jun 06; 134(22):9428-37. PMID: 22590971; PMCID: PMC3904230.
      View in: PubMed, PubMed Central
    46. Liu Y, Joo KI, Wang P. Endocytic processing of adeno-associated virus type 8 vectors for transduction of target cells. Gene Ther. 2013 Mar; 20(3):308-17. PMID: 22622241.
      View in: PubMed
    47. Dai B, Xiao L, Bryson PD, Fang J, Wang P. PD-1/PD-L1 blockade can enhance HIV-1 Gag-specific T cell immunity elicited by dendritic cell-directed lentiviral vaccines. Mol Ther. 2012 Sep; 20(9):1800-9. PMID: 22588271; PMCID: PMC3437589.
      View in: PubMed, PubMed Central
    48. Xiao L, Kim J, Lim M, Dai B, Yang L, Reed SG, Baltimore D, Wang P. A TLR4 agonist synergizes with dendritic cell-directed lentiviral vectors for inducing antigen-specific immune responses. Vaccine. 2012 Mar 28; 30(15):2570-81. PMID: 22314134; PMCID: PMC3360926.
      View in: PubMed, PubMed Central
    49. Lee CL, Chou M, Dai B, Xiao L, Wang P. Construction of stable producer cells to make high-titer lentiviral vectors for dendritic cell-based vaccination. Biotechnol Bioeng. 2012 Jun; 109(6):1551-60. PMID: 22179950; PMCID: PMC3330149.
      View in: PubMed, PubMed Central
    50. Lee CL, Dang J, Joo KI, Wang P. Engineered lentiviral vectors pseudotyped with a CD4 receptor and a fusogenic protein can target cells expressing HIV-1 envelope proteins. Virus Res. 2011 Sep; 160(1-2):340-50. PMID: 21802459; PMCID: PMC3495169.
      View in: PubMed, PubMed Central
    51. Froelich S, Tai A, Kennedy K, Zubair A, Wang P. Virus-receptor mediated transduction of dendritic cells by lentiviruses enveloped with glycoproteins derived from Semliki Forest virus. PLoS One. 2011; 6(6):e21491. PMID: 21738680; PMCID: PMC3124512.
      View in: PubMed, PubMed Central
    52. Froelich S, Tai A, Kennedy K, Zubair A, Wang P. Pseudotyping lentiviral vectors with aura virus envelope glycoproteins for DC-SIGN-mediated transduction of dendritic cells. Hum Gene Ther. 2011 Oct; 22(10):1281-91. PMID: 21452926; PMCID: PMC3205794.
      View in: PubMed, PubMed Central
    53. Zhao M, Biswas A, Hu B, Joo KI, Wang P, Gu Z, Tang Y. Redox-responsive nanocapsules for intracellular protein delivery. Biomaterials. 2011 Aug; 32(22):5223-30. PMID: 21514660.
      View in: PubMed
    54. Joo KI, Fang Y, Liu Y, Xiao L, Gu Z, Tai A, Lee CL, Tang Y, Wang P. Enhanced real-time monitoring of adeno-associated virus trafficking by virus-quantum dot conjugates. ACS Nano. 2011 May 24; 5(5):3523-35. PMID: 21473596; PMCID: PMC3132586.
      View in: PubMed, PubMed Central
    55. Nagao T, Suzuki K, Utsunomiya K, Matsumura M, Saiga K, Wang PC, Minamitani H, Aratani Y, Nakayama T, Suzuki K. Direct activation of glomerular endothelial cells by anti-moesin activity of anti-myeloperoxidase antibody. Nephrol Dial Transplant. 2011 Sep; 26(9):2752-60. PMID: 21378392.
      View in: PubMed
    56. Yang HG, Hu BL, Xiao L, Wang P. Dendritic cell-directed lentivector vaccine induces antigen-specific immune responses against murine melanoma. Cancer Gene Ther. 2011 May; 18(5):370-80. PMID: 21372855.
      View in: PubMed
    57. Lei Y, Lee CL, Joo KI, Zarzar J, Liu Y, Dai B, Fox V, Wang P. Gene editing of human embryonic stem cells via an engineered baculoviral vector carrying zinc-finger nucleases. Mol Ther. 2011 May; 19(5):942-50. PMID: 21326219; PMCID: PMC3098635.
      View in: PubMed, PubMed Central
    58. Tai A, Froelich S, Joo KI, Wang P. Production of lentiviral vectors with enhanced efficiency to target dendritic cells by attenuating mannosidase activity of mammalian cells. J Biol Eng. 2011 Jan 28; 5(1):1. PMID: 21276219; PMCID: PMC3039557.
      View in: PubMed, PubMed Central
    59. Biswas A, Joo KI, Liu J, Zhao M, Fan G, Wang P, Gu Z, Tang Y. Endoprotease-mediated intracellular protein delivery using nanocapsules. ACS Nano. 2011 Feb 22; 5(2):1385-94. PMID: 21268592.
      View in: PubMed
    60. Hu B, Tai A, Wang P. Immunization delivered by lentiviral vectors for cancer and infectious diseases. Immunol Rev. 2011 Jan; 239(1):45-61. PMID: 21198664; PMCID: PMC3030993.
      View in: PubMed, PubMed Central
    61. Nagarah JM, Paek E, Luo Y, Wang P, Hwang GS, Heath JR. Batch fabrication of high-performance planar patch-clamp devices in quartz. Adv Mater. 2010 Nov 02; 22(41):4622-7. PMID: 20830714.
      View in: PubMed
    62. Joo KI, Tai A, Lee CL, Wong C, Wang P. Imaging multiple intermediates of single-virus membrane fusion mediated by distinct fusion proteins. Microsc Res Tech. 2010 Sep; 73(9):886-900. PMID: 20232362; PMCID: PMC2930027.
      View in: PubMed, PubMed Central
    63. Hu B, Dai B, Wang P. Vaccines delivered by integration-deficient lentiviral vectors targeting dendritic cells induces strong antigen-specific immunity. Vaccine. 2010 Sep 24; 28(41):6675-83. PMID: 20709004; PMCID: PMC2956406.
      View in: PubMed, PubMed Central
    64. Gu Z, Biswas A, Joo KI, Hu B, Wang P, Tang Y. Probing protease activity by single-fluorescent-protein nanocapsules. Chem Commun (Camb). 2010 Sep 21; 46(35):6467-9. PMID: 20657917.
      View in: PubMed
    65. Froelich S, Tai A, Wang P. Lentiviral vectors for immune cells targeting. Immunopharmacol Immunotoxicol. 2010 Jun; 32(2):208-18. PMID: 20085508; PMCID: PMC2864798.
      View in: PubMed, PubMed Central
    66. Lei Y, Joo KI, Zarzar J, Wong C, Wang P. Targeting lentiviral vector to specific cell types through surface displayed single chain antibody and fusogenic molecule. Virol J. 2010 Feb 11; 7:35. PMID: 20149250; PMCID: PMC2830192.
      View in: PubMed, PubMed Central
    67. Gu Z, Yan M, Hu B, Joo KI, Biswas A, Huang Y, Lu Y, Wang P, Tang Y. Protein nanocapsule weaved with enzymatically degradable polymeric network. Nano Lett. 2009 Dec; 9(12):4533-8. PMID: 19995089.
      View in: PubMed
    68. Hu B, Yang H, Dai B, Tai A, Wang P. Nonintegrating lentiviral vectors can effectively deliver ovalbumin antigen for induction of antitumor immunity. Hum Gene Ther. 2009 Dec; 20(12):1652-64. PMID: 19663564; PMCID: PMC2799785.
      View in: PubMed, PubMed Central
    69. Dai B, Yang L, Yang H, Hu B, Baltimore D, Wang P. HIV-1 Gag-specific immunity induced by a lentivector-based vaccine directed to dendritic cells. Proc Natl Acad Sci U S A. 2009 Dec 01; 106(48):20382-7. PMID: 19918062; PMCID: PMC2777969.
      View in: PubMed, PubMed Central
    70. Tang Y, Wang P, Van Deventer JA, Link AJ, Tirrell DA. Introduction of an aliphatic ketone into recombinant proteins in a bacterial strain that overexpresses an editing-impaired leucyl-tRNA synthetase. Chembiochem. 2009 Sep 04; 10(13):2188-90. PMID: 19670197; PMCID: PMC3184883.
      View in: PubMed, PubMed Central
    71. Froelich S, Ziegler L, Stroup K, Wang P. Targeted gene delivery to CD117-expressing cells in vivo with lentiviral vectors co-displaying stem cell factor and a fusogenic molecule. Biotechnol Bioeng. 2009 Sep 01; 104(1):206-15. PMID: 19452500; PMCID: PMC2716405.
      View in: PubMed, PubMed Central
    72. Li R, Beebe T, Cui J, Rouhanizadeh M, Ai L, Wang P, Gundersen M, Takabe W, Hsiai TK. Pulsatile shear stress increased mitochondrial membrane potential: implication of Mn-SOD. Biochem Biophys Res Commun. 2009 Oct 16; 388(2):406-12. PMID: 19666009; PMCID: PMC2746082.
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    73. Lei Y, Joo KI, Wang P. Engineering fusogenic molecules to achieve targeted transduction of enveloped lentiviral vectors. J Biol Eng. 2009 Jun 02; 3:8. PMID: 19490632; PMCID: PMC2698826.
      View in: PubMed, PubMed Central
    74. Yang H, Joo KI, Ziegler L, Wang P. Cell type-specific targeting with surface-engineered lentiviral vectors co-displaying OKT3 antibody and fusogenic molecule. Pharm Res. 2009 Jun; 26(6):1432-45. PMID: 19259792; PMCID: PMC2798122.
      View in: PubMed, PubMed Central
    75. Dai B, Wang P. In vitro differentiation of adult bone marrow progenitors into antigen-specific CD4 helper T cells using engineered stromal cells expressing a notch ligand and a major histocompatibility complex class II protein. Stem Cells Dev. 2009 Mar; 18(2):235-45. PMID: 18680390; PMCID: PMC2656584.
      View in: PubMed, PubMed Central
    76. Yamaguchi A, Takagawa H, Iwakaji H, Miyagawa S, Wang PC, Ishii N. Construction of the plasmid, expression by Chinese hamster ovary cell, purification and characterization of the first three short consensus repeat modules of human complement receptor type 1. J Biochem. 2009 Apr; 145(4):533-42. PMID: 19218189.
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    77. Luo XM, Maarschalk E, O'Connell RM, Wang P, Yang L, Baltimore D. Engineering human hematopoietic stem/progenitor cells to produce a broadly neutralizing anti-HIV antibody after in vitro maturation to human B lymphocytes. Blood. 2009 Feb 12; 113(7):1422-31. PMID: 19059876.
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    78. Yang H, Ziegler L, Joo KI, Cho T, Lei Y, Wang P. Gamma-retroviral vectors enveloped with an antibody and an engineered fusogenic protein achieved antigen-specific targeting. Biotechnol Bioeng. 2008 Oct 01; 101(2):357-68. PMID: 18435481; PMCID: PMC2561946.
      View in: PubMed, PubMed Central
    79. Ziegler L, Yang L, Joo Ki, Yang H, Baltimore D, Wang P. Targeting lentiviral vectors to antigen-specific immunoglobulins. Hum Gene Ther. 2008 Sep; 19(9):861-72. PMID: 18590376; PMCID: PMC2599792.
      View in: PubMed, PubMed Central
    80. Joo KI, Lei Y, Lee CL, Lo J, Xie J, Hamm-Alvarez SF, Wang P. Site-specific labeling of enveloped viruses with quantum dots for single virus tracking. ACS Nano. 2008 Aug; 2(8):1553-62. PMID: 19079775.
      View in: PubMed
    81. Chhabra A, Yang L, Wang P, Comin-Anduix B, Das R, Chakraborty NG, Ray S, Mehrotra S, Yang H, Hardee CL, Hollis R, Dorsky DI, Koya R, Kohn DB, Ribas A, Economou JS, Baltimore D, Mukherji B. CD4+CD25- T cells transduced to express MHC class I-restricted epitope-specific TCR synthesize Th1 cytokines and exhibit MHC class I-restricted cytolytic effector function in a human melanoma model. J Immunol. 2008 Jul 15; 181(2):1063-70. PMID: 18606658; PMCID: PMC2715965.
      View in: PubMed, PubMed Central
    82. Joo KI, Wang P. Visualization of targeted transduction by engineered lentiviral vectors. Gene Ther. 2008 Oct; 15(20):1384-96. PMID: 18480844; PMCID: PMC2575058.
      View in: PubMed, PubMed Central
    83. Yang L, Yang H, Rideout K, Cho T, Joo KI, Ziegler L, Elliot A, Walls A, Yu D, Baltimore D, Wang P. Engineered lentivector targeting of dendritic cells for in vivo immunization. Nat Biotechnol. 2008 Mar; 26(3):326-34. PMID: 18297056; PMCID: PMC2366162.
      View in: PubMed, PubMed Central
    84. Yamashita K, Sato A, Asashima M, Wang PC, Nishinakamura R. Mouse homolog of SALL1, a causative gene for Townes-Brocks syndrome, binds to A/T-rich sequences in pericentric heterochromatin via its C-terminal zinc finger domains. Genes Cells. 2007 Feb; 12(2):171-82. PMID: 17295837.
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    85. Yang L, Bailey L, Baltimore D, Wang P. Targeting lentiviral vectors to specific cell types in vivo. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11479-84. PMID: 16864770; PMCID: PMC1518805.
      View in: PubMed, PubMed Central
    86. Okamura A, Itayagoshi M, Hagiwara T, Yamaguchi M, Kanamori T, Shinbo T, Wang PC. Poly(N-isopropylacrylamide)-graft-polypropylene membranes containing adsorbed antibody for cell separation. Biomaterials. 2005 Apr; 26(11):1287-92. PMID: 15475058.
      View in: PubMed
    87. Fujinaga Y. [Effects of lasix on intraocular pressure]. Nihon Ganka Kiyo. 1967 Mar; 18(3):326-8. PMID: 5624555.
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