Stacey Deleria Finley, PhD
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Title(s) | Professor of Biomedical Engineering and Quantitative and Computational Biology |
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School | Viterbi School of Engineering, Bme |
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Address | DRB 172 University Park Campus Los Angeles CA 90089-1111
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Phone | +1 213 740 8788 |
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vCard | Download vCard |
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Biography
| 2016 | | Keystone Symposia Fellow |
Diverse: Issues in Higher Education | 2015 | | Emerging Scholar Award |
National Academy of Engineering | 2014 | | Frontiers in Engineering Education |
University of Southern California | 2013 | | WiSE Gabilan Assistant Professorship |
Journal Biotechnology and Bioengineering | 2010 | | Elmer Gaden Jr. Award |
National Institutes of Health | 2010 | | Ruth L. Kirschstein NRSA Postdoctoral Fellowship |
UNCF/Merck Science Initiative | 2010 | | Postdoctoral Science Research Fellowship |
National Science Foundation | 2006 | | Graduate Research Fellowship |
Overview
Dr. Stacey Finley joined the Biomedical Engineering Department at USC in 2013. Dr. Finley received her Bachelor's degree in Chemical Engineering from Florida A & M University in 2004. She pursued graduate studies in Chemical Engineering and received her Ph.D. in 2009 from Northwestern University. While at Northwestern, Dr. Finley was a recipient of the NSF Graduate Research Fellowship and a participant in the NIH Biotechnology Predoctoral Training Program. Following her graduate work, Dr. Finley was a postdoctoral research fellow at Johns Hopkins University School of Medicine. She was awarded postdoctoral fellowships from the NIH National Research Service Award (NRSA) and the UNCF/Merck Science Initiative. She is a member of American Association of Cancer Research (AACR), American Institute of Chemical Engineers (AIChE), Biomedical Engineering Society (BMES), International Society for Computational Biology (ISCB), and the Society of Mathematical Biology (SMB).
Research
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Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
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Jewel Plummer Cobb: A trailblazing life of impact. Curr Biol. 2024 Dec 16; 34(24):R1205-R1211.
Finley SD. PMID: 39689683.
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Humans
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Merging Metabolic Modeling and Imaging for Screening Therapeutic Targets in Colorectal Cancer. bioRxiv. 2024 Dec 05.
Tavakoli N, Fong EJ, Coleman A, Huang YK, Bigger M, Doche ME, Kim S, Lenz HJ, Graham NA, Macklin P, Finley SD, Mumenthaler SM. PMID: 38826317; PMCID: PMC11142224.
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Age-associated imbalance in immune cell regeneration varies across individuals and arises from a distinct subset of stem cells. Cell Mol Immunol. 2024 Dec; 21(12):1459-1473.
Nogalska A, Eerdeng J, Akre S, Vergel-Rodriguez M, Lee Y, Bramlett C, Chowdhury AY, Wang B, Cess CG, Finley SD, Lu R. PMID: 39443746; PMCID: PMC11607082.
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AnimalsCells
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Integrating mechanism-based T cell phenotypes into a model of tumor-immune cell interactions. APL Bioeng. 2024 Sep; 8(3):036111.
Tangella N, Cess CG, Ildefonso GV, Finley SD. PMID: 39175956; PMCID: PMC11341129.
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Modeling the heterogeneous apoptotic response of caspase-mediated signaling in tumor cells. J Theor Biol. 2024 08 07; 590:111857.
Mangrum DS, Finley SD. PMID: 38797470.
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HumansCells
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Integrating Diversity, Equity, and Inclusion into Preclinical, Clinical, and Public Health Mathematical Models. Bull Math Biol. 2024 Apr 16; 86(5):56.
Sheen J, Curtin L, Finley S, Konstorum A, McGee R, Craig M. PMID: 38625656; PMCID: PMC11021228.
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PHPublic Health
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Flux sampling in genome-scale metabolic modeling of microbial communities. BMC Bioinformatics. 2024 Jan 29; 25(1):45.
Gelbach PE, Cetin H, Finley SD. PMID: 38287239; PMCID: PMC10826046.
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2 Fields:
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Information-Theoretic Analysis of a Model of CAR-4-1BB-Mediated NFκB Activation. Bull Math Biol. 2023 12 01; 86(1):5.
Tserunyan V, Finley S. PMID: 38038772; PMCID: PMC10691998.
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HumansCells
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Genome-scale modeling predicts metabolic differences between macrophage subtypes in colorectal cancer. iScience. 2023 Sep 15; 26(9):107569.
Gelbach PE, Finley SD. PMID: 37664588; PMCID: PMC10474475.
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5
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A data-driven Boolean model explains memory subsets and evolution in CD8+ T cell exhaustion. NPJ Syst Biol Appl. 2023 07 31; 9(1):36.
Ildefonso GV, Finley SD. PMID: 37524735; PMCID: PMC10390540.
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3 Fields:
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HumansCells
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Information-theoretic analysis of a model of CAR-4-1BB-mediated NFκB activation. bioRxiv. 2023 Jun 10.
Tserunyan V, Finley S. PMID: 37333129; PMCID: PMC10274880.
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A systems and computational biology perspective on advancing CAR therapy. Semin Cancer Biol. 2023 09; 94:34-49.
Tserunyan V, Finley SD. PMID: 37263529; PMCID: PMC10529846.
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1 Fields:
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HumansCells
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Calibrating agent-based models to tumor images using representation learning. PLoS Comput Biol. 2023 04; 19(4):e1011070.
Cess CG, Finley SD. PMID: 37083821; PMCID: PMC10156003.
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9 Fields:
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Humans
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Flux Sampling in Genome-scale Metabolic Modeling of Microbial Communities. bioRxiv. 2023 Apr 20.
Gelbach PE, Finley SD. PMID: 37197028; PMCID: PMC10173371.
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Ensemble-based genome-scale modeling predicts metabolic differences between macrophage subtypes in colorectal cancer. bioRxiv. 2023 Mar 11.
Gelbach PE, Finley SD. PMID: 36993493; PMCID: PMC10052244.
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Proof-of-concept for incorporating mechanistic insights from multi-omics analyses of polymyxin B in combination with chloramphenicol against Klebsiella pneumoniae. CPT Pharmacometrics Syst Pharmacol. 2023 03; 12(3):387-400.
Hanafin PO, Abdul Rahim N, Sharma R, Cess CG, Finley SD, Bergen PJ, Velkov T, Li J, Rao GG. PMID: 36661181; PMCID: PMC10014067.
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PubMed Mentions:
1 Fields:
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HumansCells
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Systematic Bayesian posterior analysis guided by Kullback-Leibler divergence facilitates hypothesis formation. J Theor Biol. 2023 02 07; 558:111341.
Huber HA, Georgia SK, Finley SD. PMID: 36335999.
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2 Fields:
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Kinetic and data-driven modeling of pancreatic β-cell central carbon metabolism and insulin secretion. PLoS Comput Biol. 2022 10; 18(10):e1010555.
Gelbach PE, Zheng D, Fraser SE, White KL, Graham NA, Finley SD. PMID: 36251711; PMCID: PMC9612825.
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PubMed Mentions:
3 Fields:
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Cells
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Computational analysis of 4-1BB-induced NFκB signaling suggests improvements to CAR cell design. Cell Commun Signal. 2022 08 26; 20(1):129.
Tserunyan V, Finley SD. PMID: 36028884; PMCID: PMC9413922.
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PubMed Mentions:
2 Fields:
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Cells
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Modelling predicts differences in chimeric antigen receptor T-cell signalling due to biological variability. R Soc Open Sci. 2022 Aug; 9(8):220137.
Tserunyan V, Finley SD. PMID: 36039281; PMCID: PMC9399690.
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3
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Phosphatases are predicted to govern prolactin-mediated JAK-STAT signaling in pancreatic beta cells. Integr Biol (Camb). 2022 04 08; 14(2):37-48.
Simoni AD, Huber HA, Georgia SK, Finley SD. PMID: 35368075.
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HumansCells
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Exogenous Lactogenic Signaling Stimulates Beta Cell Replication In Vivo and In Vitro. Biomolecules. 2022 01 26; 12(2).
Millette K, Rodriguez K, Sheng X, Finley SD, Georgia S. PMID: 35204716; PMCID: PMC8961548.
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2 Fields:
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HumansAnimalsCells
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Mechanistic characterization of endothelial sprouting mediated by pro-angiogenic signaling. Microcirculation. 2022 02; 29(2):e12744.
Song M, Finley SD. PMID: 34890488; PMCID: PMC9285777.
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4 Fields:
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Cells
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Challenges and opportunities in 2021. Nat Cancer. 2021 12; 2(12):1278-1283.
Akkari L, Finley SD, Ho PC, Jenkins M, Maier BB, McGranahan N, Mutebi M, Perera RM, Robles-Espinoza CD, Vardhana S, Wan L, Xu MM. PMID: 35121916.
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Elucidating tumor-stromal metabolic crosstalk in colorectal cancer through integration of constraint-based models and LC-MS metabolomics. Metab Eng. 2022 01; 69:175-187.
Wang J, Delfarah A, Gelbach PE, Fong E, Macklin P, Mumenthaler SM, Graham NA, Finley SD. PMID: 34838998; PMCID: PMC8818109.
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9 Fields:
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HumansCells
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A field guide to cultivating computational biology. PLoS Biol. 2021 10; 19(10):e3001419.
Way GP, Greene CS, Carninci P, Carvalho BS, de Hoon M, Finley SD, Gosline SJC, L? Cao KA, Lee JSH, Marchionni L, Robine N, Sindi SS, Theis FJ, Yang JYH, Carpenter AE, Fertig EJ. PMID: 34618807; PMCID: PMC8525744.
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8 Fields:
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Humans
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Fund Black scientists. Cell. 2021 02 04; 184(3):561-565.
Stevens KR, Masters KS, Imoukhuede PI, Haynes KA, Setton LA, Cosgriff-Hernandez E, Lediju Bell MA, Rangamani P, Sakiyama-Elbert SE, Finley SD, Willits RK, Koppes AN, Chesler NC, Christman KL, Allen JB, Wong JY, El-Samad H, Desai TA, Eniola-Adefeso O. PMID: 33503447.
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56 Fields:
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Humans
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Multi-scale modeling of macrophage-T cell interactions within the tumor microenvironment. PLoS Comput Biol. 2020 12; 16(12):e1008519.
Cess CG, Finley SD. PMID: 33362239; PMCID: PMC7790427.
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33 Fields:
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HumansAnimalsCells
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An optimal control approach for enhancing natural killer cells' secretion of cytolytic molecules. APL Bioeng. 2020 Dec; 4(4):046107.
Makaryan SZ, Finley SD. PMID: 33376936; PMCID: PMC7758091.
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2
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Dynamic Regulation of JAK-STAT Signaling Through the Prolactin Receptor Predicted by Computational Modeling. Cell Mol Bioeng. 2021 Feb; 14(1):15-30.
Mortlock RD, Georgia SK, Finley SD. PMID: 33633812; PMCID: PMC7878662.
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4
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ERK and Akt exhibit distinct signaling responses following stimulation by pro-angiogenic factors. Cell Commun Signal. 2020 07 17; 18(1):114.
Song M, Finley SD. PMID: 32680529; PMCID: PMC7368799.
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24 Fields:
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HumansAnimalsCells
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Enhancing network activation in natural killer cells: predictions from in silico modeling. Integr Biol (Camb). 2020 05 21; 12(5):109-121.
Makaryan SZ, Finley SD. PMID: 32409824; PMCID: PMC7480959.
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5 Fields:
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HumansCells
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Mathematical Model Predicts Effective Strategies to Inhibit VEGF-eNOS Signaling. J Clin Med. 2020 Apr 26; 9(5).
Wu Q, Finley SD. PMID: 32357492; PMCID: PMC7287924.
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8
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ERK Activation in CAR T Cells Is Amplified by CD28-Mediated Increase in CD3ζ Phosphorylation. iScience. 2020 Apr 24; 23(4):101023.
Rohrs JA, Siegler EL, Wang P, Finley SD. PMID: 32325413; PMCID: PMC7178546.
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16
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Modeling immune cell behavior across scales in cancer. Wiley Interdiscip Rev Syst Biol Med. 2020 07; 12(4):e1484.
Makaryan SZ, Cess CG, Finley SD. PMID: 32129950; PMCID: PMC7317398.
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PubMed Mentions:
13 Fields:
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HumansCells
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Data-driven analysis of a mechanistic model of CAR T cell signaling predicts effects of cell-to-cell heterogeneity. J Theor Biol. 2020 03 21; 489:110125.
Cess CG, Finley SD. PMID: 31866395; PMCID: PMC7467855.
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11 Fields:
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HumansCells
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Exploring the Extracellular Regulation of the Tumor Angiogenic Interaction Network Using a Systems Biology Model. Front Physiol. 2019; 10:823.
Li D, Finley SD. PMID: 31379588; PMCID: PMC6656929.
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4
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Integrative Approaches to Cancer Immunotherapy. Trends Cancer. 2019 07; 5(7):400-410.
Szeto GL, Finley SD. PMID: 31311655; PMCID: PMC7467854.
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PubMed Mentions:
66 Fields:
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Humans
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The 2019 mathematical oncology roadmap. Phys Biol. 2019 06 19; 16(4):041005.
Rockne RC, Hawkins-Daarud A, Swanson KR, Sluka JP, Glazier JA, Macklin P, Hormuth DA, Jarrett AM, Lima EABF, Tinsley Oden J, Biros G, Yankeelov TE, Curtius K, Al Bakir I, Wodarz D, Komarova N, Aparicio L, Bordyuh M, Rabadan R, Finley SD, Enderling H, Caudell J, Moros EG, Anderson ARA, Gatenby RA, Kaznatcheev A, Jeavons P, Krishnan N, Pelesko J, Wadhwa RR, Yoon N, Nichol D, Marusyk A, Hinczewski M, Scott JG. PMID: 30991381; PMCID: PMC6655440.
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71 Fields:
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Humans
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Metabolic reprogramming dynamics in tumor spheroids: Insights from a multicellular, multiscale model. PLoS Comput Biol. 2019 06; 15(6):e1007053.
Roy M, Finley SD. PMID: 31185009; PMCID: PMC6588258.
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PubMed Mentions:
14 Fields:
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HumansCells
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Understanding the Dynamics of T-Cell Activation in Health and Disease Through the Lens of Computational Modeling. JCO Clin Cancer Inform. 2019 01; 3:1-8.
Rohrs JA, Wang P, Finley SD. PMID: 30689404; PMCID: PMC6593125.
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PubMed Mentions:
13 Fields:
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HumansAnimalsCells
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Mechanistic insight into activation of MAPK signaling by pro-angiogenic factors. BMC Syst Biol. 2018 12 27; 12(1):145.
Song M, Finley SD. PMID: 30591051; PMCID: PMC6307205.
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PubMed Mentions:
29 Fields:
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Cells
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Computational Model of Chimeric Antigen Receptors Explains Site-Specific Phosphorylation Kinetics. Biophys J. 2018 09 18; 115(6):1116-1129.
Rohrs JA, Zheng D, Graham NA, Wang P, Finley SD. PMID: 30197180; PMCID: PMC6139883.
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PubMed Mentions:
24 Fields:
Translation:
Cells
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In silico mouse study identifies tumour growth kinetics as biomarkers for the outcome of anti-angiogenic treatment. J R Soc Interface. 2018 08; 15(145).
Wu Q, Arnheim AD, Finley SD. PMID: 30135261; PMCID: PMC6127173.
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PubMed Mentions:
5 Fields:
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Animals
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The impact of tumor receptor heterogeneity on the response to anti-angiogenic cancer treatment. Integr Biol (Camb). 2018 04 23; 10(4):253-269.
Li D, Finley SD. PMID: 29623971; PMCID: PMC7467857.
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PubMed Mentions:
8 Fields:
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Humans
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Mechanistic modeling quantifies the influence of tumor growth kinetics on the response to anti-angiogenic treatment. PLoS Comput Biol. 2017 12; 13(12):e1005874.
Gaddy TD, Wu Q, Arnheim AD, Finley SD. PMID: 29267273; PMCID: PMC5739350.
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9 Fields:
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Humans
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Predictive model identifies strategies to enhance TSP1-mediated apoptosis signaling. Cell Commun Signal. 2017 Dec 19; 15(1):53.
Wu Q, Finley SD. PMID: 29258506; PMCID: PMC5735807.
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PubMed Mentions:
9 Fields:
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HumansCells
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Computational Model Predicts the Effects of Targeting Cellular Metabolism in Pancreatic Cancer. Front Physiol. 2017; 8:217.
Roy M, Finley SD. PMID: 28446878; PMCID: PMC5388762.
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31
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Monitoring Severity of Multiple Organ Dysfunction Syndrome: New Technologies. Pediatr Crit Care Med. 2017 Mar; 18(3_suppl Suppl 1):S24-S31.
Typpo KV, Wong HR, Finley SD, Daniels RC, Seely AJ, Lacroix J. PMID: 28248831; PMCID: PMC5333164.
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PubMed Mentions:
7 Fields:
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Humans
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A multiscale computational model predicts distribution of anti-angiogenic isoform VEGF165b in peripheral arterial disease in human and mouse. Sci Rep. 2016 11 17; 6:37030.
Chu LH, Ganta VC, Choi MH, Chen G, Finley SD, Annex BH, Popel AS. PMID: 27853189; PMCID: PMC5113071.
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PubMed Mentions:
8 Fields:
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HumansAnimalsCells
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Predictive model of thrombospondin-1 and vascular endothelial growth factor in breast tumor tissue. NPJ Syst Biol Appl. 2016; 2.
Rohrs JA, Sulistio CD, Finley SD. PMID: 28713587; PMCID: PMC5507330.
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17 Fields:
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Predictive Model of Lymphocyte-Specific Protein Tyrosine Kinase (LCK) Autoregulation. Cell Mol Bioeng. 2016; 9:351-367.
Rohrs JA, Wang P, Finley SD. PMID: 27547268; PMCID: PMC4978775.
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14
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A cancer treatment based on synergy between anti-angiogenic and immune cell therapies. J Theor Biol. 2016 Apr 07; 394:197-211.
Soto-Ortiz L, Finley SD. PMID: 26826488; PMCID: PMC7467856.
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PubMed Mentions:
8 Fields:
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HumansCells
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Pharmacokinetics of Anti-VEGF Agent Aflibercept in Cancer Predicted by Data-Driven, Molecular-Detailed Model. CPT Pharmacometrics Syst Pharmacol. 2015 Nov; 4(11):641-9.
Finley SD, Angelikopoulos P, Koumoutsakos P, Popel AS. PMID: 26783500; PMCID: PMC4716581.
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11 Fields:
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Computational systems biology approaches to anti-angiogenic cancer therapeutics. Drug Discov Today. 2015 Feb; 20(2):187-97.
Finley SD, Chu LH, Popel AS. PMID: 25286370; PMCID: PMC4336587.
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PubMed Mentions:
35 Fields:
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Humans
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A systems biology view of blood vessel growth and remodelling. J Cell Mol Med. 2014 Aug; 18(8):1491-508.
Logsdon EA, Finley SD, Popel AS, Mac Gabhann F. PMID: 24237862; PMCID: PMC4190897.
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PubMed Mentions:
77 Fields:
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HumansAnimals
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Compartment model predicts VEGF secretion and investigates the effects of VEGF trap in tumor-bearing mice. Front Oncol. 2013; 3:196.
Finley SD, Dhar M, Popel AS. PMID: 23908970; PMCID: PMC3727077.
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28
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Effect of tumor microenvironment on tumor VEGF during anti-VEGF treatment: systems biology predictions. J Natl Cancer Inst. 2013 Jun 05; 105(11):802-11.
Finley SD, Popel AS. PMID: 23670728; PMCID: PMC3672077.
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PubMed Mentions:
48 Fields:
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HumansAnimals
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Predicting the effects of anti-angiogenic agents targeting specific VEGF isoforms. AAPS J. 2012 Sep; 14(3):500-9.
Finley SD, Popel AS. PMID: 22547351; PMCID: PMC3385824.
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35 Fields:
Translation:
HumansCells
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Pharmacokinetics and pharmacodynamics of VEGF-neutralizing antibodies. BMC Syst Biol. 2011 Nov 21; 5:193.
Finley SD, Engel-Stefanini MO, Imoukhuede PI, Popel AS. PMID: 22104283; PMCID: PMC3229549.
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33 Fields:
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HumansAnimalsCells
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A two-compartment model of VEGF distribution in the mouse. PLoS One. 2011; 6(11):e27514.
Yen P, Finley SD, Engel-Stefanini MO, Popel AS. PMID: 22087332; PMCID: PMC3210788.
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26 Fields:
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AnimalsCells
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Timescale analysis of rule-based biochemical reaction networks. Biotechnol Prog. 2012 Jan-Feb; 28(1):33-44.
Klinke DJ, Finley SD. PMID: 21954150; PMCID: PMC3381993.
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PubMed Mentions:
10 Fields:
Translation:
Cells
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Inferring relevant control mechanisms for interleukin-12 signaling in naïve CD4+ T cells. Immunol Cell Biol. 2011 Jan; 89(1):100-10.
Finley SD, Gupta D, Cheng N, Klinke DJ. PMID: 20479776; PMCID: PMC3004982.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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In silico feasibility of novel biodegradation pathways for 1,2,4-trichlorobenzene. BMC Syst Biol. 2010 Feb 02; 4:7.
Finley SD, Broadbelt LJ, Hatzimanikatis V. PMID: 20122273; PMCID: PMC2830930.
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PubMed Mentions:
10 Fields:
Translation:
CellsPHPublic Health
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Computational framework for predictive biodegradation. Biotechnol Bioeng. 2009 Dec 15; 104(6):1086-97.
Finley SD, Broadbelt LJ, Hatzimanikatis V. PMID: 19650084; PMCID: PMC4073782.
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PubMed Mentions:
24 Fields:
Translation:
PHPublic Health
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Thermodynamic analysis of biodegradation pathways. Biotechnol Bioeng. 2009 Jun 15; 103(3):532-41.
Finley SD, Broadbelt LJ, Hatzimanikatis V. PMID: 19288443; PMCID: PMC4073797.
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PubMed Mentions:
17 Fields:
This graph shows the total number of publications by year. To see the data as text,
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This graph shows the total number of publications by year. To return to the graph,
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Year | Publications |
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2009 | 2 |
2010 | 2 |
2011 | 3 |
2012 | 1 |
2013 | 3 |
2014 | 1 |
2015 | 1 |
2016 | 4 |
2017 | 4 |
2018 | 4 |
2019 | 6 |
2020 | 8 |
2021 | 5 |
2022 | 6 |
2023 | 9 |
2024 | 7 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
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