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Jerry SH Lee, PhD

Title(s)Associate Professor of Clinical Medicine and Chemical Engineering and Material Sciences
Address2250 Alcazar Street
Health Sciences Campus
Los Angeles CA 90033
ORCID ORCID Icon0000-0003-1515-0952 Additional info
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    Other Positions
    Title(s)Chief Science and Innovation Officer of the Lawrence J. Ellison Institute for Transformative Medicine


    Collapse Biography 
    Collapse Education and Training
    Johns Hopkins University, Baltimore, MDPhD2006Chemical and Biomolecular Engineering
    Johns Hopkins University, Baltimore, MDBS2001Biomedical Engineering
    Collapse Awards and Honors
    National Cancer Institute2014  - 2017Director's Merit Award
    National Cancer Institute2010  - 2012Director's Merit Award
    NASA2004  - 2006NASA Graduate Student Research Fellowship Award
    2004Tau Beta Pi

    Collapse Overview 
    Collapse Overview
    Dr. Lee is an Associate Professor of Clinical Medicine and Chemical Engineering & Material Sciences at the University of Southern California Keck School of Medicine and Viterbi School of Engineering. As the Chief Science and Innovation Officer for the Lawrence J. Ellison Institute for Transformative Medicine of USC, he provides leadership, guidance, vision, and development of research capabilities for executing the Institute’s research projects and will be responsible for planning, implementing, and evaluating scientific direction, projects, and funding to sustain high-impact programs in support of a bold vision to transform cancer research in the 21st century.

    Prior to joining USC, Dr. Lee served for more than a decade as a Health Sciences Director within the National Cancer Institute’s Office of the Director. Through direct support and use of public-public/public-private partnerships, he deployed programs focused on the integration of advanced technologies, trans-disciplinary approaches, infrastructures, and standards, to accelerate the creation of publicly available, broadly accessible, multi-dimensional data, knowledge, and tools to empower the entire cancer research continuum for patient benefit.

    In 2016, Dr. Lee was assigned to Office of the Vice President to serve as the Deputy Director for Cancer Research and Technology for the White House Cancer Moonshot Task Force. A few key efforts he helped coordinate include the Applied Proteogenomics OrganizationaL Learning and Outcomes (APOLLO) Network, international collaborations to share molecular characterization datasets, the Blood Profiling Atlas in Cancer pilot, as well as co-chairing an interagency group focused on cancer data and technology policy issues.

    Dr. Lee’s research involves elucidating the interplay between biophysical and biochemical drivers of age-related diseases and has co-authored over twenty papers, five book chapters, and one book. He is a member of the Department of Veterans Affairs’ National Research Advisory Council, the National Academies Board on Science, Technology, and Economic Policy’s Innovation Policy Forum, and the Health and Environmental Sciences Institute’s Board of Trustees. Dr. Lee earned his B.S. degree in biomedical engineering and Ph.D. in chemical and biomolecular engineering from Johns Hopkins University.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Contribution Of Care Source To Cancer Treatment Cost Variation In The US Military Health System. Health Aff (Millwood). 2019 08; 38(8):1335-1342. Eaglehouse YL, Aljehani M, Georg MW, Castellanos O, Lee JSH, Seabury SA, Shriver CD, Zhu K. PMID: 31381409.
      View in: PubMed   Mentions:    Fields:    
    2. Patient reported outcomes can improve performance status assessment: a pilot study. J Patient Rep Outcomes. 2019 Jul 16; 3(1):41. Broderick JE, May M, Schwartz JE, Li M, Mejia A, Nocera L, Kolatkar A, Ueno NT, Yennu S, Lee JSH, Hanlon SE, Cozzens Philips FA, Shahabi C, Kuhn P, Nieva J. PMID: 31313047.
      View in: PubMed   Mentions:
    3. Harnessing the Power of Collaboration and Training Within Clinical Data Science to Generate Real-World Evidence in the Era of Precision Oncology. Clin Pharmacol Ther. 2019 07; 106(1):60-66. Rivera DR, Lee JSH, Hsu E, Khoury MJ, Meng F, Olivero O, Penberthy L, Tourassi GD. PMID: 31166005.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. From Discovery to Practice and Survivorship: Building a National Real-World Data Learning Healthcare Framework for Military and Veteran Cancer Patients. Clin Pharmacol Ther. 2019 07; 106(1):52-57. Lee JSH, Darcy KM, Hu H, Casablanca Y, Conrads TP, Dalgard CL, Freymann JB, Hanlon SE, Huang GD, Kvecher L, Maxwell GL, Meng F, Moncur JT, Turner C, Wells JM, Wilkerson MD, Zhu K, Ramoni RB, Shriver CD. PMID: 30838639.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Tumor cell density regulates matrix metalloproteinases for enhanced migration. Oncotarget. 2018 Aug 24; 9(66):32556-32569. Jayatilaka H, Umanzor FG, Shah V, Meirson T, Russo G, Starich B, Tyle P, Lee JSH, Khatau S, Gil-Henn H, Wirtz D. PMID: 30220965.
      View in: PubMed   Mentions: 1     Fields:    
    6. Data Harmonization for a Molecularly Driven Health System. Cell. 2018 08 23; 174(5):1045-1048. Lee JS, Kibbe WA, Grossman RL. PMID: 30142341.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Residual tissue repositories as a resource for population-based cancer proteomic studies. Clin Proteomics. 2018; 15:26. Piehowski PD, Petyuk VA, Sontag RL, Gritsenko MA, Weitz KK, Fillmore TL, Moon J, Makhlouf H, Chuaqui RF, Boja ES, Rodriguez H, Lee JSH, Smith RD, Carrick DM, Liu T, Rodland KD. PMID: 30087585.
      View in: PubMed   Mentions:
    8. A comparison of methods to assess cell mechanical properties. Nat Methods. 2018 07; 15(7):491-498. Wu PH, Aroush DR, Asnacios A, Chen WC, Dokukin ME, Doss BL, Durand-Smet P, Ekpenyong A, Guck J, Guz NV, Janmey PA, Lee JSH, Moore NM, Ott A, Poh YC, Ros R, Sander M, Sokolov I, Staunton JR, Wang N, Whyte G, Wirtz D. PMID: 29915189.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    9. Opportunities and Challenges in Implementation of Multiparameter Single Cell Analysis Platforms for Clinical Translation. Clin Transl Sci. 2018 05; 11(3):267-276. Keating SM, Taylor DL, Plant AL, Litwack ED, Kuhn P, Greenspan EJ, Hartshorn CM, Sigman CC, Kelloff GJ, Chang DD, Friberg G, Lee JSH, Kuida K. PMID: 29498218.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    10. Aligned fibers direct collective cell migration to engineer closing and nonclosing wound gaps. Mol Biol Cell. 2017 Sep 15; 28(19):2579-2588. Sharma P, Ng C, Jana A, Padhi A, Szymanski P, Lee JSH, Behkam B, Nain AS. PMID: 28747440.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    11. Biophysical and biomolecular determination of cellular age in humans. Nat Biomed Eng. 2017 Jul; 1(7). Phillip JM, Wu PH, Gilkes DM, Williams W, McGovern S, Daya J, Chen J, Aifuwa I, Lee JSH, Fan R, Walston J, Wirtz D. PMID: 31372309.
      View in: PubMed   Mentions: 5     Fields:    
    12. Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration. Nat Commun. 2017 05 26; 8:15584. Jayatilaka H, Tyle P, Chen JJ, Kwak M, Ju J, Kim HJ, Lee JSH, Wu PH, Gilkes DM, Fan R, Wirtz D. PMID: 28548090.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    13. Cancer Therapy: Shooting for the Moon. Clin Pharmacol Ther. 2017 05; 101(5):552-558. Lee J, Blumenthal GM, Hohl RJ, Huang SM. PMID: 28418166.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Collaborating to Compete: Blood Profiling Atlas in Cancer (BloodPAC) Consortium. Clin Pharmacol Ther. 2017 May; 101(5):589-592. Grossman RL, Abel B, Angiuoli S, Barrett JC, Bassett D, Bramlett K, Blumenthal GM, Carlsson A, Cortese R, DiGiovanna J, Davis-Dusenbery B, Dittamore R, Eberhard DA, Febbo P, Fitzsimons M, Flamig Z, Godsey J, Goswami J, Gruen A, Ortuño F, Han J, Hayes D, Hicks J, Holloway D, Hovelson D, Johnson J, Juhl H, Kalamegham R, Kamal R, Kang Q, Kelloff GJ, Klozenbuecher M, Kolatkar A, Kuhn P, Langone K, Leary R, Loverso P, Manmathan H, Martin AM, Martini J, Miller D, Mitchell M, Morgan T, Mulpuri R, Nguyen T, Otto G, Pathak A, Peters E, Philip R, Posadas E, Reese D, Reese MG, Robinson D, Dei Rossi A, Sakul H, Schageman J, Singh S, Scher HI, Schmitt K, Silvestro A, Simmons J, Simmons T, Sislow J, Talasaz A, Tang P, Tewari M, Tomlins S, Toukhy H, Tseng HR, Tuck M, Tzou A, Vinson J, Wang Y, Wells W, Welsh A, Wilbanks J, Wolf J, Young L, Lee J, Leiman LC. PMID: 28187516.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    15. Innovative Methodologies to Drive Enrollment of Molecularly Defined Patient Populations for Diagnostic-Enabled Basket Studies. Journal of Precision Medicine. 2017; (5):34-39. Kowak, E., P. Multani, W. McCarthy, Z. Hornby, G. Li, R. Landin, M. Yamamoto, J. Christiansen, J.S.H. Lee, J. Lim.
    16. Determination of Cellular Biological Age in Health and Disease. Nature Biomedical Engineering. 2017; (1):0093. Phillip, J.M., P. Wu, D.M. Gilkes, W. Williams, S. McGovern, J. Daya, J. Chen, R. Fan, J.S.H. Lee, J. Walston, D. Wirtz.
    17. Advancing Convergence and Innovation in Cancer Research: National Cancer Institute Center for Strategic Scientific Initiatives (CSSI). Electrochemical Society Transactions. 2017; 10(80):1315-1318. Elder, S.G. and J.S.H. Lee..
    18. Proliferation and enrichment of CD133(+) glioblastoma cancer stem cells on 3D chitosan-alginate scaffolds. Biomaterials. 2014 Nov; 35(33):9137-43. Kievit FM, Florczyk SJ, Leung MC, Wang K, Wu JD, Silber JR, Ellenbogen RG, Lee JS, Zhang M. PMID: 25109438.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    19. Targeted peptide measurements in biology and medicine: best practices for mass spectrometry-based assay development using a fit-for-purpose approach. Mol Cell Proteomics. 2014 Mar; 13(3):907-17. Carr SA, Abbatiello SE, Ackermann BL, Borchers C, Domon B, Deutsch EW, Grant RP, Hoofnagle AN, Hüttenhain R, Koomen JM, Liebler DC, Liu T, MacLean B, Mani DR, Mansfield E, Neubert H, Paulovich AG, Reiter L, Vitek O, Aebersold R, Anderson L, Bethem R, Blonder J, Boja E, Botelho J, Boyne M, Bradshaw RA, Burlingame AL, Chan D, Keshishian H, Kuhn E, Kinsinger C, Lee JS, Lee SW, Moritz R, Oses-Prieto J, Rifai N, Ritchie J, Rodriguez H, Srinivas PR, Townsend RR, Van Eyk J, Whiteley G, Wiita A, Weintraub S. PMID: 24443746.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimals
    20. Intracellular Particle Tracking Rheometry. CRC Handbook of Imaging in Biological Mechanics. 2014; 381-388. Dawson, M., Y. Tseng, J.S.H. Lee, K.M. McAndrews.
    21. Piloting an approach to rapid and automated assessment of a new research initiative: Application to the National Cancer Institute's Provocative Questions initiative. Res Eval. 2013 Dec; 22(5):272-284. Hsu ER, Williams DE, Dijoseph LG, Schnell JD, Finstad SL, Lee JS, Greenspan EJ, Corrigan JG. PMID: 24808631.
      View in: PubMed   Mentions:
    22. Aligned chitosan-polycaprolactone polyblend nanofibers promote the migration of glioblastoma cells. Adv Healthc Mater. 2013 Dec; 2(12):1651-9. Kievit FM, Cooper A, Jana S, Leung MC, Wang K, Edmondson D, Wood D, Lee JS, Ellenbogen RG, Zhang M. PMID: 23776187.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    23. Functional interplay between the cell cycle and cell phenotypes. Integr Biol (Camb). 2013 Mar; 5(3):523-34. Chen WC, Wu PH, Phillip JM, Khatau SB, Choi JM, Dallas MR, Konstantopoulos K, Sun SX, Lee JS, Hodzic D, Wirtz D. PMID: 23319145.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    24. Vascular Cell Physiology Under Shear Flow: Role of Cell Mechanics and Mechanotransduction. Mechanical and Chemical Signalling in Angiogenesis, Studies in Mechanobiology, Tissue Engineering, and Biomaterials. 2013; (12):121-141. Scott, D., W. Tan, J.S.H. Lee, O.J.T. McCarty, M.T. Hinds.
    25. Considerations in the development of circulating tumor cell technology for clinical use. J Transl Med. 2012 Jul 02; 10:138. Parkinson DR, Dracopoli N, Petty BG, Compton C, Cristofanilli M, Deisseroth A, Hayes DF, Kapke G, Kumar P, Lee JSh, Liu MC, McCormack R, Mikulski S, Nagahara L, Pantel K, Pearson-White S, Punnoose EA, Roadcap LT, Schade AE, Scher HI, Sigman CC, Kelloff GJ. PMID: 22747748.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansCells
    26. The differential formation of the LINC-mediated perinuclear actin cap in pluripotent and somatic cells. PLoS One. 2012; 7(5):e36689. Khatau SB, Kusuma S, Hanjaya-Putra D, Mali P, Cheng L, Lee JS, Gerecht S, Wirtz D. PMID: 22574215.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    27. High-throughput ballistic injection nanorheology to measure cell mechanics. Nat Protoc. 2012 Jan 05; 7(1):155-70. Wu PH, Hale CM, Chen WC, Lee JS, Tseng Y, Wirtz D. PMID: 22222790.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    28. SMRT analysis of MTOC and nuclear positioning reveals the role of EB1 and LIC1 in single-cell polarization. J Cell Sci. 2011 Dec 15; 124(Pt 24):4267-85. Hale CM, Chen WC, Khatau SB, Daniels BR, Lee JS, Wirtz D. PMID: 22193958.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    29. Physical oncology. Preface. Phys Biol. 2011 Feb; 8(1):010301. Lee JS, Wirtz D. PMID: 21368347.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. De-convoluting cancer's complexity: using a 'physical sciences lens' to provide a different (clearer) perspective of cancer. Preface. Phys Biol. 2011 Feb; 8(1):010302. Moore NM, Kuhn NZ, Hanlon SE, Lee JS, Nagahara LA. PMID: 21368346.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    31. Intra- and Extracellular Microrheology of Endothelial Cells in 3D Matrix. Biological and Medical Physics, Biomedical Engineering: Biophysical Regulation of Vascular Differentiation and Assembly. 2011; (1):69-87. Fraley, S.I., C.M. Hale, R.J. Bloom, A. Celedon, J.S.H. Lee, D. Wirtz.
    32. Strategic workshops on cancer nanotechnology. Cancer Res. 2010 Jun 01; 70(11):4265-8. Nagahara LA, Lee JS, Molnar LK, Panaro NJ, Farrell D, Ptak K, Alper J, Grodzinski P. PMID: 20460532.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    33. Inhibition of tumor-cell invasion with chlorotoxin-bound superparamagnetic nanoparticles. Small. 2009 Feb; 5(2):256-64. Veiseh O, Gunn JW, Kievit FM, Sun C, Fang C, Lee JS, Zhang M. PMID: 19089837.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimals
    34. Magnetic nanoparticles in MR imaging and drug delivery. Adv Drug Deliv Rev. 2008 Aug 17; 60(11):1252-65. Sun C, Lee JS, Zhang M. PMID: 18558452.
      View in: PubMed   Mentions: 254     Fields:    Translation:HumansAnimals
    35. Next Generation Nanosolutions for Cancer Treatment and Diagnosis. Cancer and Chemotherapy Reviews. 2008; (3):144-151. Lee, J.S.H., J. Cheng, K.Y. Kim.
    36. Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration. Biophys J. 2007 Oct 01; 93(7):2542-52. Lee JS, Hale CM, Panorchan P, Khatau SB, George JP, Tseng Y, Stewart CL, Hodzic D, Wirtz D. PMID: 17631533.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    37. Probing cellular mechanical responses to stimuli using ballistic intracellular nanorheology. Methods Cell Biol. 2007; 83:115-40. Panorchan P, Lee JS, Daniels BR, Kole TP, Tseng Y, Wirtz D. PMID: 17613307.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    38. Microrheology and ROCK signaling of human endothelial cells embedded in a 3D matrix. Biophys J. 2006 Nov 01; 91(9):3499-507. Panorchan P, Lee JS, Kole TP, Tseng Y, Wirtz D. PMID: 16891369.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    39. Ballistic intracellular nanorheology reveals ROCK-hard cytoplasmic stiffening response to fluid flow. J Cell Sci. 2006 May 01; 119(Pt 9):1760-8. Lee JS, Panorchan P, Hale CM, Khatau SB, Kole TP, Tseng Y, Wirtz D. PMID: 16636071.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    40. How actin crosslinking and bundling proteins cooperate to generate an enhanced cell mechanical response. Biochem Biophys Res Commun. 2005 Aug 19; 334(1):183-92. Tseng Y, Kole TP, Lee JS, Fedorov E, Almo SC, Schafer BW, Wirtz D. PMID: 15992772.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    41. Cdc42 mediates nucleus movement and MTOC polarization in Swiss 3T3 fibroblasts under mechanical shear stress. Mol Biol Cell. 2005 Feb; 16(2):871-80. Lee JS, Chang MI, Tseng Y, Wirtz D. PMID: 15548602.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    42. Micro-organization and visco-elasticity of the interphase nucleus revealed by particle nanotracking. J Cell Sci. 2004 Apr 15; 117(Pt 10):2159-67. Tseng Y, Lee JS, Kole TP, Jiang I, Wirtz D. PMID: 15090601.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    43. Local Dynamics and Viscoelastic Properties of Cell Biological Systems. Current Opinion in Colloid & Interface Science. 2002; (7):210-217. Tseng Y., T.P. Kole, S.H.J. Lee, D. Wirtz.
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