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Jerry SH Lee, PhD

Title(s)Associate Professor of Clinical Medicine and Chemical Engineering and Material Sciences
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    Other Positions
    Title(s)Chief Science and Innovation Officer of the Lawrence J. Ellison Institute for Transformative Medicine


    Collapse Biography 
    Collapse Education and Training
    Johns Hopkins University, Baltimore, MDPhD2006Chemical and Biomolecular Engineering
    Johns Hopkins University, Baltimore, MDBS2001Biomedical Engineering
    Collapse Awards and Honors
    National Cancer Institute2014  - 2017Director's Merit Award
    National Cancer Institute2010  - 2012Director's Merit Award
    NASA2004  - 2006NASA Graduate Student Research Fellowship Award
    2004Tau Beta Pi

    Collapse Overview 
    Collapse Overview
    Dr. Lee is an Associate Professor of Clinical Medicine and Chemical Engineering & Material Sciences at the University of Southern California Keck School of Medicine and Viterbi School of Engineering. As the Chief Science and Innovation Officer for the Lawrence J. Ellison Institute for Transformative Medicine of USC, he provides leadership, guidance, vision, and development of research capabilities for executing the Institute’s research projects and will be responsible for planning, implementing, and evaluating scientific direction, projects, and funding to sustain high-impact programs in support of a bold vision to transform cancer research in the 21st century.

    Prior to joining USC, Dr. Lee served for more than a decade as a Health Sciences Director within the National Cancer Institute’s Office of the Director. Through direct support and use of public-public/public-private partnerships, he deployed programs focused on the integration of advanced technologies, trans-disciplinary approaches, infrastructures, and standards, to accelerate the creation of publicly available, broadly accessible, multi-dimensional data, knowledge, and tools to empower the entire cancer research continuum for patient benefit.

    In 2016, Dr. Lee was assigned to Office of the Vice President to serve as the Deputy Director for Cancer Research and Technology for the White House Cancer Moonshot Task Force. A few key efforts he helped coordinate include the Applied Proteogenomics OrganizationaL Learning and Outcomes (APOLLO) Network, international collaborations to share molecular characterization datasets, the Blood Profiling Atlas in Cancer pilot, as well as co-chairing an interagency group focused on cancer data and technology policy issues.

    Dr. Lee’s research involves elucidating the interplay between biophysical and biochemical drivers of age-related diseases and has co-authored over twenty papers, five book chapters, and one book. He is a member of the Department of Veterans Affairs’ National Research Advisory Council, the National Academies Board on Science, Technology, and Economic Policy’s Innovation Policy Forum, and the Health and Environmental Sciences Institute’s Board of Trustees. Dr. Lee earned his B.S. degree in biomedical engineering and Ph.D. in chemical and biomolecular engineering from Johns Hopkins University.

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Eaglehouse YL, Aljehani M, Georg MW, Castellanos O, Lee JSH, Seabury SA, Shriver CD, Zhu K. Contribution Of Care Source To Cancer Treatment Cost Variation In The US Military Health System. Health Aff (Millwood). 2019 Aug; 38(8):1335-1342. PMID: 31381409.
      View in: PubMed
    2. Broderick JE, May M, Schwartz JE, Li M, Mejia A, Nocera L, Kolatkar A, Ueno NT, Yennu S, Lee JSH, Hanlon SE, Cozzens Philips FA, Shahabi C, Kuhn P, Nieva J. Patient reported outcomes can improve performance status assessment: a pilot study. J Patient Rep Outcomes. 2019 Jul 16; 3(1):41. PMID: 31313047.
      View in: PubMed
    3. Rivera DR, Lee JSH, Hsu E, Khoury MJ, Meng F, Olivero O, Penberthy L, Tourassi GD. Harnessing the Power of Collaboration and Training Within Clinical Data Science to Generate Real-World Evidence in the Era of Precision Oncology. Clin Pharmacol Ther. 2019 Jul; 106(1):60-66. PMID: 31166005.
      View in: PubMed
    4. Lee JSH, Darcy KM, Hu H, Casablanca Y, Conrads TP, Dalgard CL, Freymann JB, Hanlon SE, Huang GD, Kvecher L, Maxwell GL, Meng F, Moncur JT, Turner C, Wells JM, Wilkerson MD, Zhu K, Ramoni RB, Shriver CD. From Discovery to Practice and Survivorship: Building a National Real-World Data Learning Healthcare Framework for Military and Veteran Cancer Patients. Clin Pharmacol Ther. 2019 Jul; 106(1):52-57. PMID: 30838639.
      View in: PubMed
    5. Jayatilaka H, Umanzor FG, Shah V, Meirson T, Russo G, Starich B, Tyle P, Lee JSH, Khatau S, Gil-Henn H, Wirtz D. Tumor cell density regulates matrix metalloproteinases for enhanced migration. Oncotarget. 2018 Aug 24; 9(66):32556-32569. PMID: 30220965.
      View in: PubMed
    6. Lee JS, Kibbe WA, Grossman RL. Data Harmonization for a Molecularly Driven Health System. Cell. 2018 Aug 23; 174(5):1045-1048. PMID: 30142341.
      View in: PubMed
    7. Piehowski PD, Petyuk VA, Sontag RL, Gritsenko MA, Weitz KK, Fillmore TL, Moon J, Makhlouf H, Chuaqui RF, Boja ES, Rodriguez H, Lee JSH, Smith RD, Carrick DM, Liu T, Rodland KD. Residual tissue repositories as a resource for population-based cancer proteomic studies. Clin Proteomics. 2018; 15:26. PMID: 30087585.
      View in: PubMed
    8. Wu PH, Aroush DR, Asnacios A, Chen WC, Dokukin ME, Doss BL, Durand-Smet P, Ekpenyong A, Guck J, Guz NV, Janmey PA, Lee JSH, Moore NM, Ott A, Poh YC, Ros R, Sander M, Sokolov I, Staunton JR, Wang N, Whyte G, Wirtz D. A comparison of methods to assess cell mechanical properties. Nat Methods. 2018 Jul; 15(7):491-498. PMID: 29915189.
      View in: PubMed
    9. Keating SM, Taylor DL, Plant AL, Litwack ED, Kuhn P, Greenspan EJ, Hartshorn CM, Sigman CC, Kelloff GJ, Chang DD, Friberg G, Lee JSH, Kuida K. Opportunities and Challenges in Implementation of Multiparameter Single Cell Analysis Platforms for Clinical Translation. Clin Transl Sci. 2018 05; 11(3):267-276. PMID: 29498218.
      View in: PubMed
    10. Sharma P, Ng C, Jana A, Padhi A, Szymanski P, Lee JSH, Behkam B, Nain AS. Aligned fibers direct collective cell migration to engineer closing and nonclosing wound gaps. Mol Biol Cell. 2017 Sep 15; 28(19):2579-2588. PMID: 28747440.
      View in: PubMed
    11. Phillip JM, Wu PH, Gilkes DM, Williams W, McGovern S, Daya J, Chen J, Aifuwa I, Lee JSH, Fan R, Walston J, Wirtz D. Biophysical and biomolecular determination of cellular age in humans. Nat Biomed Eng. 2017 Jul; 1(7). PMID: 31372309.
      View in: PubMed
    12. Jayatilaka H, Tyle P, Chen JJ, Kwak M, Ju J, Kim HJ, Lee JSH, Wu PH, Gilkes DM, Fan R, Wirtz D. Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration. Nat Commun. 2017 05 26; 8:15584. PMID: 28548090.
      View in: PubMed
    13. Lee J, Blumenthal GM, Hohl RJ, Huang SM. Cancer Therapy: Shooting for the Moon. Clin Pharmacol Ther. 2017 05; 101(5):552-558. PMID: 28418166.
      View in: PubMed
    14. Grossman RL, Abel B, Angiuoli S, Barrett JC, Bassett D, Bramlett K, Blumenthal GM, Carlsson A, Cortese R, DiGiovanna J, Davis-Dusenbery B, Dittamore R, Eberhard DA, Febbo P, Fitzsimons M, Flamig Z, Godsey J, Goswami J, Gruen A, Ortuño F, Han J, Hayes D, Hicks J, Holloway D, Hovelson D, Johnson J, Juhl H, Kalamegham R, Kamal R, Kang Q, Kelloff GJ, Klozenbuecher M, Kolatkar A, Kuhn P, Langone K, Leary R, Loverso P, Manmathan H, Martin AM, Martini J, Miller D, Mitchell M, Morgan T, Mulpuri R, Nguyen T, Otto G, Pathak A, Peters E, Philip R, Posadas E, Reese D, Reese MG, Robinson D, Dei Rossi A, Sakul H, Schageman J, Singh S, Scher HI, Schmitt K, Silvestro A, Simmons J, Simmons T, Sislow J, Talasaz A, Tang P, Tewari M, Tomlins S, Toukhy H, Tseng HR, Tuck M, Tzou A, Vinson J, Wang Y, Wells W, Welsh A, Wilbanks J, Wolf J, Young L, Lee J, Leiman LC. Collaborating to Compete: Blood Profiling Atlas in Cancer (BloodPAC) Consortium. Clin Pharmacol Ther. 2017 May; 101(5):589-592. PMID: 28187516.
      View in: PubMed
    15. Kowak, E., P. Multani, W. McCarthy, Z. Hornby, G. Li, R. Landin, M. Yamamoto, J. Christiansen, J.S.H. Lee, J. Lim. .Innovative Methodologies to Drive Enrollment of Molecularly Defined Patient Populations for Diagnostic-Enabled Basket Studies. Journal of Precision Medicine. 2017; (5):34-39.
    16. Phillip, J.M., P. Wu, D.M. Gilkes, W. Williams, S. McGovern, J. Daya, J. Chen, R. Fan, J.S.H. Lee, J. Walston, D. Wirtz.Determination of Cellular Biological Age in Health and Disease. Nature Biomedical Engineering. 2017; (1):0093.
    17. Elder, S.G. and J.S.H. Lee.Advancing Convergence and Innovation in Cancer Research: National Cancer Institute Center for Strategic Scientific Initiatives (CSSI). Electrochemical Society Transactions. 2017; 10(80):1315-1318.
    18. Kievit FM, Florczyk SJ, Leung MC, Wang K, Wu JD, Silber JR, Ellenbogen RG, Lee JS, Zhang M. Proliferation and enrichment of CD133(+) glioblastoma cancer stem cells on 3D chitosan-alginate scaffolds. Biomaterials. 2014 Nov; 35(33):9137-43. PMID: 25109438.
      View in: PubMed
    19. Carr SA, Abbatiello SE, Ackermann BL, Borchers C, Domon B, Deutsch EW, Grant RP, Hoofnagle AN, Hüttenhain R, Koomen JM, Liebler DC, Liu T, MacLean B, Mani DR, Mansfield E, Neubert H, Paulovich AG, Reiter L, Vitek O, Aebersold R, Anderson L, Bethem R, Blonder J, Boja E, Botelho J, Boyne M, Bradshaw RA, Burlingame AL, Chan D, Keshishian H, Kuhn E, Kinsinger C, Lee JS, Lee SW, Moritz R, Oses-Prieto J, Rifai N, Ritchie J, Rodriguez H, Srinivas PR, Townsend RR, Van Eyk J, Whiteley G, Wiita A, Weintraub S. Targeted peptide measurements in biology and medicine: best practices for mass spectrometry-based assay development using a fit-for-purpose approach. Mol Cell Proteomics. 2014 Mar; 13(3):907-17. PMID: 24443746; PMCID: PMC3945918.
    20. Dawson, M., Y. Tseng, J.S.H. Lee, K.M. McAndrews. .Intracellular Particle Tracking Rheometry. CRC Handbook of Imaging in Biological Mechanics. 2014; 381-388.
    21. Hsu ER, Williams DE, Dijoseph LG, Schnell JD, Finstad SL, Lee JS, Greenspan EJ, Corrigan JG. Piloting an approach to rapid and automated assessment of a new research initiative: Application to the National Cancer Institute's Provocative Questions initiative. Res Eval. 2013 Dec; 22(5):272-284. PMID: 24808631.
      View in: PubMed
    22. Kievit FM, Cooper A, Jana S, Leung MC, Wang K, Edmondson D, Wood D, Lee JS, Ellenbogen RG, Zhang M. Aligned chitosan-polycaprolactone polyblend nanofibers promote the migration of glioblastoma cells. Adv Healthc Mater. 2013 Dec; 2(12):1651-9. PMID: 23776187.
      View in: PubMed
    23. Chen WC, Wu PH, Phillip JM, Khatau SB, Choi JM, Dallas MR, Konstantopoulos K, Sun SX, Lee JS, Hodzic D, Wirtz D. Functional interplay between the cell cycle and cell phenotypes. Integr Biol (Camb). 2013 Mar; 5(3):523-34. PMID: 23319145.
      View in: PubMed
    24. Scott, D., W. Tan, J.S.H. Lee, O.J.T. McCarty, M.T. Hinds.Vascular Cell Physiology Under Shear Flow: Role of Cell Mechanics and Mechanotransduction. Mechanical and Chemical Signalling in Angiogenesis, Studies in Mechanobiology, Tissue Engineering, and Biomaterials. 2013; (12):121-141.
    25. Parkinson DR, Dracopoli N, Petty BG, Compton C, Cristofanilli M, Deisseroth A, Hayes DF, Kapke G, Kumar P, Lee JSh, Liu MC, McCormack R, Mikulski S, Nagahara L, Pantel K, Pearson-White S, Punnoose EA, Roadcap LT, Schade AE, Scher HI, Sigman CC, Kelloff GJ. Considerations in the development of circulating tumor cell technology for clinical use. J Transl Med. 2012 Jul 02; 10:138. PMID: 22747748.
      View in: PubMed
    26. Khatau SB, Kusuma S, Hanjaya-Putra D, Mali P, Cheng L, Lee JS, Gerecht S, Wirtz D. The differential formation of the LINC-mediated perinuclear actin cap in pluripotent and somatic cells. PLoS One. 2012; 7(5):e36689. PMID: 22574215.
      View in: PubMed
    27. Wu PH, Hale CM, Chen WC, Lee JS, Tseng Y, Wirtz D. High-throughput ballistic injection nanorheology to measure cell mechanics. Nat Protoc. 2012 Jan 05; 7(1):155-70. PMID: 22222790.
      View in: PubMed
    28. Hale CM, Chen WC, Khatau SB, Daniels BR, Lee JS, Wirtz D. SMRT analysis of MTOC and nuclear positioning reveals the role of EB1 and LIC1 in single-cell polarization. J Cell Sci. 2011 Dec 15; 124(Pt 24):4267-85. PMID: 22193958.
      View in: PubMed
    29. Lee JS, Wirtz D. Physical oncology. Preface. Phys Biol. 2011 Feb; 8(1):010301. PMID: 21368347.
      View in: PubMed
    30. Moore NM, Kuhn NZ, Hanlon SE, Lee JS, Nagahara LA. De-convoluting cancer's complexity: using a 'physical sciences lens' to provide a different (clearer) perspective of cancer. Preface. Phys Biol. 2011 Feb; 8(1):010302. PMID: 21368346.
      View in: PubMed
    31. Fraley, S.I., C.M. Hale, R.J. Bloom, A. Celedon, J.S.H. Lee, D. Wirtz.Intra- and Extracellular Microrheology of Endothelial Cells in 3D Matrix. Biological and Medical Physics, Biomedical Engineering: Biophysical Regulation of Vascular Differentiation and Assembly. 2011; (1):69-87.
    32. Nagahara LA, Lee JS, Molnar LK, Panaro NJ, Farrell D, Ptak K, Alper J, Grodzinski P. Strategic workshops on cancer nanotechnology. Cancer Res. 2010 Jun 01; 70(11):4265-8. PMID: 20460532.
      View in: PubMed
    33. Veiseh O, Gunn JW, Kievit FM, Sun C, Fang C, Lee JS, Zhang M. Inhibition of tumor-cell invasion with chlorotoxin-bound superparamagnetic nanoparticles. Small. 2009 Feb; 5(2):256-64. PMID: 19089837.
      View in: PubMed
    34. Sun C, Lee JS, Zhang M. Magnetic nanoparticles in MR imaging and drug delivery. Adv Drug Deliv Rev. 2008 Aug 17; 60(11):1252-65. PMID: 18558452.
      View in: PubMed
    35. Lee, J.S.H., J. Cheng, K.Y. Kim. .Next Generation Nanosolutions for Cancer Treatment and Diagnosis. Cancer and Chemotherapy Reviews. 2008; (3):144-151.
    36. Lee JS, Hale CM, Panorchan P, Khatau SB, George JP, Tseng Y, Stewart CL, Hodzic D, Wirtz D. Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration. Biophys J. 2007 Oct 01; 93(7):2542-52. PMID: 17631533; PMCID: PMC1965451.
    37. Panorchan P, Lee JS, Daniels BR, Kole TP, Tseng Y, Wirtz D. Probing cellular mechanical responses to stimuli using ballistic intracellular nanorheology. Methods Cell Biol. 2007; 83:115-40. PMID: 17613307.
      View in: PubMed
    38. Panorchan P, Lee JS, Kole TP, Tseng Y, Wirtz D. Microrheology and ROCK signaling of human endothelial cells embedded in a 3D matrix. Biophys J. 2006 Nov 01; 91(9):3499-507. PMID: 16891369.
      View in: PubMed
    39. Lee JS, Panorchan P, Hale CM, Khatau SB, Kole TP, Tseng Y, Wirtz D. Ballistic intracellular nanorheology reveals ROCK-hard cytoplasmic stiffening response to fluid flow. J Cell Sci. 2006 May 01; 119(Pt 9):1760-8. PMID: 16636071.
      View in: PubMed
    40. Tseng Y, Kole TP, Lee JS, Fedorov E, Almo SC, Schafer BW, Wirtz D. How actin crosslinking and bundling proteins cooperate to generate an enhanced cell mechanical response. Biochem Biophys Res Commun. 2005 Aug 19; 334(1):183-92. PMID: 15992772.
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    41. Lee JS, Chang MI, Tseng Y, Wirtz D. Cdc42 mediates nucleus movement and MTOC polarization in Swiss 3T3 fibroblasts under mechanical shear stress. Mol Biol Cell. 2005 Feb; 16(2):871-80. PMID: 15548602.
      View in: PubMed
    42. Tseng Y, Lee JS, Kole TP, Jiang I, Wirtz D. Micro-organization and visco-elasticity of the interphase nucleus revealed by particle nanotracking. J Cell Sci. 2004 Apr 15; 117(Pt 10):2159-67. PMID: 15090601.
      View in: PubMed
    43. Tseng Y., T.P. Kole, S.H.J. Lee, D. Wirtz.Local Dynamics and Viscoelastic Properties of Cell Biological Systems. Current Opinion in Colloid & Interface Science. 2002; (7):210-217.