Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Shannon M Mumenthaler, PhD

    TitleAssistant Professor of Medicine
    SchoolKeck School of Medicine of USC
    AddressCSC 2250 Alcazar St. Ste. 240
    Off Campus
    Los Angeles California 90089-9075
    Phone+1 323 442 2529
    vCardDownload vCard

      Collapse Overview 
      Collapse Overview
      Dr. Mumenthaler is an Assistant Professor of Research Medicine at the CAMM. She received a B.S. in Genetics from UC Davis and a Ph.D. in Cellular and Molecular Pathology from UCLA. Although her primary scientific training is in cell biology, Dr. Mumenthaler applies a unique multidisciplinary approach toward her research program, partnering with mathematicians, clinicians, and engineers to explore critical areas in cancer. Her current research interests focus on the development of tools to better understand the evolutionary dynamics of tumor progression and drug resistance with specific investigations into the influence of microenvironmental selective pressures on tumor cell behavior. Toward this goal, Dr. Mumenthaler is closely collaborating with mathematical modelers to combine novel computational platforms with diverse experimental measurements to test and refine biological hypotheses and make clinically relevant predictions.

      Collapse Biography 
      Collapse Awards and Honors
      Webber Foundation1999  - 2003Academic Scholarship
      University of California, Davis2000Alumni Scholarship
      University of California, Davis2002Howard Hughes Medical Institute Summer Honors Advanced Research Program (SHARP) Fellowship
      University of California, Davis2003Graduated with Honors
      University of California, Davis2003Undergraduate Student of the Year Award, Division of Biological Sciences
      University of California, Los Angeles2005  - 2006Life Sciences Core Curriculum Teaching Assistant Honorarium Award
      University of California, Los Angeles2006  - 2007Hortenese Fishbaugh Memorial Scholarship
      Third Annual National Cancer Institute Physical Sciences in Oncology Center2012Best Poster Award
      National Cancer Institute2013Junior Investigator Award
      USC2013Medical Faculty Women's Association Award

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Garvey CM, Gerhart TA, Mumenthaler S. Discrimination and Characterization of Heterocellular Populations Using Quantitative Imaging Techniques. J Vis Exp. 2017 Jun 30; (124). PMID: 28715383.
        View in: PubMed
      2. Patsch K, Chiu CL, Engeln M, Agus DB, Mallick P, Mumenthaler S, Ruderman D. Single cell dynamic phenotyping. Sci Rep. 2016 Oct 06; 6:34785. PMID: 27708391.
        View in: PubMed
      3. Juarez EF, Lau R, Friedman SH, Ghaffarizadeh A, Jonckheere E, Agus DB, Mumenthaler S, Macklin P. Quantifying differences in cell line population dynamics using CellPD. BMC Syst Biol. 2016 Sep 21; 10(1):92. PMID: 27655224.
        View in: PubMed
      4. Lindsay D, Garvey CM, Mumenthaler S, Foo J. Leveraging Hypoxia-Activated Prodrugs to Prevent Drug Resistance in Solid Tumors. PLoS Comput Biol. 2016 Aug; 12(8):e1005077. PMID: 27560187; PMCID: PMC4999195.
      5. Park SM, Lee JY, Hong S, Lee SH, Dimov IK, Lee H, Suh S, Pan Q, Li K, Wu AM, Mumenthaler S, Mallick P, Lee LP. Dual transcript and protein quantification in a massive single cell array. Lab Chip. 2016 Oct 07; 16(19):3682-8. PMID: 27546183.
        View in: PubMed
      6. Garvey CM, Spiller E, Lindsay D, Chiang CT, Choi NC, Agus DB, Mallick P, Foo J, Mumenthaler S. A high-content image-based method for quantitatively studying context-dependent cell population dynamics. Sci Rep. 2016 Jul 25; 6:29752. PMID: 27452732; PMCID: PMC4958988.
      7. Yadav VK, Smith KS, Flinders C, Mumenthaler S, De S. Significance of duon mutations in cancer genomes. Sci Rep. 2016 Jun 08; 6:27437. PMID: 27272679; PMCID: PMC4897603.
      8. Macklin P, Frieboes HB, Sparks JL, Ghaffarizadeh A, Friedman SH, Juarez EF, Jonckheere E, Mumenthaler S. Progress Towards Computational 3-D Multicellular Systems Biology. Adv Exp Med Biol. 2016; 936:225-246. PMID: 27739051.
        View in: PubMed
      9. Mumenthaler S, Foo J, Choi NC, Heise N, Leder K, Agus DB, Pao W, Michor F, Mallick P. The Impact of Microenvironmental Heterogeneity on the Evolution of Drug Resistance in Cancer Cells. Cancer Inform. 2015; 14(Suppl 4):19-31. PMID: 26244007; PMCID: PMC4504404.
      10. Frieboes HB, Smith BR, Wang Z, Kotsuma M, Ito K, Day A, Cahill B, Flinders C, Mumenthaler S, Mallick P, Simbawa E, Al-Fhaid AS, Mahmoud SR, Gambhir SS, Cristini V. Predictive Modeling of Drug Response in Non-Hodgkin's Lymphoma. PLoS One. 2015; 10(6):e0129433. PMID: 26061425; PMCID: PMC4464754.
      11. Yang-Kolodji G, Mumenthaler S, Mehta A, Ji L, Tripathy D. Phosphorylated ribosomal S6 (p-rpS6) as a post-treatment indicator of HER2 signalling targeted drug resistance. Biomarkers. 2015; 20(5):313-22. PMID: 26329528.
        View in: PubMed
      12. Li K, Tavaré R, Zettlitz KA, Mumenthaler S, Mallick P, Zhou Y, Marks JD, Wu AM. Anti-MET immunoPET for non-small cell lung cancer using novel fully human antibody fragments. Mol Cancer Ther. 2014 Nov; 13(11):2607-17. PMID: 25143449; PMCID: PMC4221648.
      13. Mumenthaler S, D'Antonio G, Preziosi L, Macklin P. The Need for Integrative Computational Oncology: An Illustrated Example through MMP-Mediated Tissue Degradation. Front Oncol. 2013; 3:194. PMID: 23898463; PMCID: PMC3724164.
      14. Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler S, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH. A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep. 2013; 3:1449. PMID: 23618955; PMCID: PMC3636513.
      15. Foo J, Leder K, Mumenthaler S. Cancer as a moving target: understanding the composition and rebound growth kinetics of recurrent tumors. Evol Appl. 2013 Jan; 6(1):54-69. PMID: 23396647; PMCID: PMC3567471.
      16. Mumenthaler S, Foo J, Leder K, Choi NC, Agus DB, Pao W, Mallick P, Michor F. Evolutionary modeling of combination treatment strategies to overcome resistance to tyrosine kinase inhibitors in non-small cell lung cancer. Mol Pharm. 2011 Dec 05; 8(6):2069-79. PMID: 21995722; PMCID: PMC3230244.
      17. Mumenthaler S, Ng PY, Hodge A, Bearss D, Berk G, Kanekal S, Redkar S, Taverna P, Agus DB, Jain A. Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes. Mol Cancer Ther. 2009 Oct; 8(10):2882-93. PMID: 19825806; PMCID: PMC2808126.
      18. Villablanca AC, Tenwolde A, Lee M, Huck M, Mumenthaler S, Rutledge JC. 17beta-estradiol prevents early-stage atherosclerosis in estrogen receptor-alpha deficient female mice. J Cardiovasc Transl Res. 2009 Sep; 2(3):289-99. PMID: 19654889.
        View in: PubMed
      19. Bernstein HB, Wang G, Plasterer MC, Zack JA, Ramasastry P, Mumenthaler S, Kitchen CM. CD4+ NK cells can be productively infected with HIV, leading to downregulation of CD4 expression and changes in function. Virology. 2009 Apr 25; 387(1):59-66. PMID: 19251297; PMCID: PMC2667870.
      20. Mumenthaler S, Rozengurt N, Livesay JC, Sabaghian A, Cederbaum SD, Grody WW. Disruption of arginase II alters prostate tumor formation in TRAMP mice. Prostate. 2008 Oct 01; 68(14):1561-9. PMID: 18663728.
        View in: PubMed
      21. Mumenthaler S, Yu H, Tze S, Cederbaum SD, Pegg AE, Seligson DB, Grody WW. Expression of arginase II in prostate cancer. Int J Oncol. 2008 Feb; 32(2):357-65. PMID: 18202758.
        View in: PubMed