Oliver Bell, PhD

Title(s)Associate Professor of Biochemistry & Molecular Medicine
SchoolKeck School of Medicine of Usc
AddressNRT6504, NRT 6510
Health Sciences Campus
Los Angeles CA 90033
ORCID ORCID Icon0000-0002-7639-5948 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Howard Hughes Medical Institutes and Stanford University School of Medicine, Stanford, CA, USAPostdoctoral Fellowship06/2013
    Friedrich Miescher Institute for Biomedical Research, Basel, SwitzerlandPhD01/2008Biochemistry
    Collapse Awards and Honors
    EMBO2009  - 2010EMBO Long-term Fellowship
    HFSPO2010  - 2012Human Frontier Science Program Long-term fellowship
    HFSPO2014  - 2018Human Frontier Science Program Career Development Award

    Collapse Overview 
    Collapse Overview
    We are interested in the mechanisms that underlie epigenetic memory of cell fate decisions. Chromatin modifications facilitate the regulation of differential expression of key control genes required for cellular differentiation. Diverse chemical modifications of nucleosomes and DNA play a fundamental role in gene regulation, shaping DNA accessibility and signaling to maintain gene expression states.

    We study the dynamic regulation of chromatin modifications and how these marks contribute to epigenetic inheritance of gene silencing. Our lab uses synthetic biology approaches in mouse embryonic stem cells to manipulate chromatin modifications and study their dynamics and inheritance.
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers. Nat Cell Biol. 2023 Jan; 25(1):42-55. Yelagandula R, Stecher K, Novatchkova M, Michetti L, Michlits G, Wang J, Hofbauer P, Vainorius G, Pribitzer C, Isbel L, Mendjan S, Schübeler D, Elling U, Brennecke J, Bell O. PMID: 36604593; PMCID: PMC10038669.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    2. Reprogramming CBX8-PRC1 function with a positive allosteric modulator. Cell Chem Biol. 2022 04 21; 29(4):555-571.e11. Suh JL, Bsteh D, Hart B, Si Y, Weaver TM, Pribitzer C, Lau R, Soni S, Ogana H, Rectenwald JM, Norris JL, Cholensky SH, Sagum C, Umana JD, Li D, Hardy B, Bedford MT, Mumenthaler SM, Lenz HJ, Kim YM, Wang GG, Pearce KH, James LI, Kireev DB, Musselman CA, Frye SV, Bell O. PMID: 34715055; PMCID: PMC9035045.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    3. Parallel PRC2/cPRC1 and vPRC1 pathways silence lineage-specific genes and maintain self-renewal in mouse embryonic stem cells. Sci Adv. 2020 04; 6(14):eaax5692. Zepeda-Martinez JA, Pribitzer C, Wang J, Bsteh D, Golumbeanu S, Zhao Q, Burkard TR, Reichholf B, Rhie SK, Jude J, Moussa HF, Zuber J, Bell O. PMID: 32270030; PMCID: PMC7112768.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    4. Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7. Cell Chem Biol. 2019 10 17; 26(10):1365-1379.e22. Lamb KN, Bsteh D, Dishman SN, Moussa HF, Fan H, Stuckey JI, Norris JL, Cholensky SH, Li D, Wang J, Sagum C, Stanton BZ, Bedford MT, Pearce KH, Kenakin TP, Kireev DB, Wang GG, James LI, Bell O, Frye SV. PMID: 31422906; PMCID: PMC6800648.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    5. Phenotype delineation of ZNF462 related syndrome. Am J Med Genet A. 2019 10; 179(10):2075-2082. Kruszka P, Hu T, Hong S, Signer R, Cogné B, Isidor B, Mazzola SE, Giltay JC, van Gassen KLI, England EM, Pais L, Ockeloen CW, Sanchez-Lara PA, Kinning E, Adams DJ, Treat K, Torres-Martinez W, Bedeschi MF, Iascone M, Blaney S, Bell O, Tan TY, Delrue MA, Jurgens J, Barry BJ, Engle EC, Savage SK, Fleischer N, Martinez-Agosto JA, Boycott K, Zackai EH, Muenke M. PMID: 31361404; PMCID: PMC6935050.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    6. Pathway-Based High-Throughput Chemical Screen Identifies Compounds That Decouple Heterochromatin Transformations. SLAS Discov. 2019 09; 24(8):802-816. MacDonald IA, Butler KV, Herring LE, Clinkscales SE, Yelagandula R, Stecher K, Bell O, Graves LM, Jin J, Hathaway NA. PMID: 31145866; PMCID: PMC6893849.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    7. Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing. Nat Commun. 2019 04 29; 10(1):1931. Moussa HF, Bsteh D, Yelagandula R, Pribitzer C, Stecher K, Bartalska K, Michetti L, Wang J, Zepeda-Martinez JA, Elling U, Stuckey JI, James LI, Frye SV, Bell O. PMID: 31036804; PMCID: PMC6488670.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    8. Nucleosome Turnover Regulates Histone Methylation Patterns over the Genome. Mol Cell. 2019 01 03; 73(1):61-72.e3. Chory EJ, Calarco JP, Hathaway NA, Bell O, Neel DS, Crabtree GR. PMID: 30472189; PMCID: PMC6510544.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    9. A reversible haploid mouse embryonic stem cell biobank resource for functional genomics. Nature. 2017 10 05; 550(7674):114-118. Elling U, Wimmer RA, Leibbrandt A, Burkard T, Michlits G, Leopoldi A, Micheler T, Abdeen D, Zhuk S, Aspalter IM, Handl C, Liebergesell J, Hubmann M, Husa AM, Kinzer M, Schuller N, Wetzel E, van de Loo N, Martinez JAZ, Estoppey D, Riedl R, Yang F, Fu B, Dechat T, Ivics Z, Agu CA, Bell O, Blaas D, Gerhardt H, Hoepfner D, Stark A, Penninger JM. PMID: 28953874; PMCID: PMC6235111.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    10. The histone chaperone CAF-1 safeguards somatic cell identity. Nature. 2015 Dec 10; 528(7581):218-24. Cheloufi S, Elling U, Hopfgartner B, Jung YL, Murn J, Ninova M, Hubmann M, Badeaux AI, Euong Ang C, Tenen D, Wesche DJ, Abazova N, Hogue M, Tasdemir N, Brumbaugh J, Rathert P, Jude J, Ferrari F, Blanco A, Fellner M, Wenzel D, Zinner M, Vidal SE, Bell O, Stadtfeld M, Chang HY, Almouzni G, Lowe SW, Rinn J, Wernig M, Aravin A, Shi Y, Park PJ, Penninger JM, Zuber J, Hochedlinger K. PMID: 26659182; PMCID: PMC4866648.
      View in: PubMed   Mentions: 136     Fields:    Translation:AnimalsCells
    11. Dynamics and memory of heterochromatin in living cells. Cell. 2012 Jun 22; 149(7):1447-60. Hathaway NA, Bell O, Hodges C, Miller EL, Neel DS, Crabtree GR. PMID: 22704655; PMCID: PMC3422694.
      View in: PubMed   Mentions: 218     Fields:    Translation:AnimalsCells
    12. Determinants and dynamics of genome accessibility. Nat Rev Genet. 2011 Jul 12; 12(8):554-64. Bell O, Tiwari VK, Thomä NH, Schübeler D. PMID: 21747402.
      View in: PubMed   Mentions: 229     Fields:    Translation:HumansAnimalsCells
    13. Accessibility of the Drosophila genome discriminates PcG repression, H4K16 acetylation and replication timing. Nat Struct Mol Biol. 2010 Jul; 17(7):894-900. Bell O, Schwaiger M, Oakeley EJ, Lienert F, Beisel C, Stadler MB, Schübeler D. PMID: 20562853.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    14. Chromatin: sub out the replacement. Curr Biol. 2009 Jul 28; 19(14):R545-7. Bell O, Schübeler D. PMID: 19640486.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    15. Chromatin state marks cell-type- and gender-specific replication of the Drosophila genome. Genes Dev. 2009 Mar 01; 23(5):589-601. Schwaiger M, Stadler MB, Bell O, Kohler H, Oakeley EJ, Schübeler D. PMID: 19270159; PMCID: PMC2658520.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    16. Transcription-coupled methylation of histone H3 at lysine 36 regulates dosage compensation by enhancing recruitment of the MSL complex in Drosophila melanogaster. Mol Cell Biol. 2008 May; 28(10):3401-9. Bell O, Conrad T, Kind J, Wirbelauer C, Akhtar A, Schübeler D. PMID: 18347056; PMCID: PMC2423169.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    17. Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. EMBO J. 2007 Dec 12; 26(24):4974-84. Bell O, Wirbelauer C, Hild M, Scharf AN, Schwaiger M, MacAlpine DM, Zilbermann F, van Leeuwen F, Bell SP, Imhof A, Garza D, Peters AH, Schübeler D. PMID: 18007591; PMCID: PMC2140113.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    18. Variant histone H3.3 is deposited at sites of nucleosomal displacement throughout transcribed genes while active histone modifications show a promoter-proximal bias. Genes Dev. 2005 Aug 01; 19(15):1761-6. Wirbelauer C, Bell O, Schübeler D. PMID: 16077006; PMCID: PMC1182337.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    19. Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2). Blood. 2005 Oct 01; 106(7):2580-9. Galy B, Ferring D, Minana B, Bell O, Janser HG, Muckenthaler M, Schümann K, Hentze MW. PMID: 15956281.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
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