We are interested in the mechanisms that underlie epigenetic memory of cell fate decisions. Chromatin modifications facilitate the regulation of differential expression of key control genes required for cellular differentiation. Diverse chemical modifications of nucleosomes and DNA play a fundamental role in gene regulation, shaping DNA accessibility and signaling to maintain gene expression states.
We study the dynamic regulation of chromatin modifications and how these marks contribute to epigenetic inheritance of gene silencing. Our lab uses synthetic biology approaches in mouse embryonic stem cells to manipulate chromatin modifications and study their dynamics and inheritance.