Suhn Kyong Rhie
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Title(s) | Assistant Professor of Biochemistry and Molecular Medicine |
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Address | 1450 Biggy Street Health Sciences Campus Los Angeles CA 90033
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Phone | +1 323 442 8145 |
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vCard | Download vCard |
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Biography University of California, Los Angeles | B.S. | 06/2007 | Biochemistry | University of Southern California | Ph.D. | 05/2013 | Genetic, Molecular and Cellular Biology |
| 2018
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| 2021 | NCI Career Development Award | | 2007 | | Women for Change | | 2007 | | Ethel Terry McCoy Award for Excellence in Chemistry and Biochemistry |
Overview Dr. Rhie received her B.S. in Biochemistry, magna cum laude from the University of California, Los Angeles. She earned her Ph.D. degree in Genetic, Molecular and Cellular Biology from the University of Southern California in 2013. She completed her postdoctoral training in the laboratories of Dr. Peter Laird and Dr. Peggy Farnham. Dr. Rhie participated in Genome-Wide Association Studies (GWAS) in different cancer types, unraveling mechanisms that explain how genetic variants affect disease risks. Dr. Rhie characterized heterogeneous tumor tissues as a leader of DNA methylation analysis for The Cancer Genome Atlas (TCGA) Consortium and discovered how genetic alterations such as somatic mutations, fusions, copy number variations are associated with epigenetic changes in cancer. She has also led epigenomic data analysis to investigate how transcription factors act at regulatory elements in a 3D nucleome structure in cancer and psychiatric diseases as part of the ENCODE and PsychENCODE Consortia. Her current research interests are to characterize key transcription factor and understand roles of regulatory elements activated in different types of cancers and neurodevelopmental diseases. By using both molecular biology and bioinformatics to address how genes are regulated in 3D nucleome structure (e.g. ChIP-seq, RNA-seq, whole genome sequencing, whole genome bisulfite sequencing, NOMe-seq, DNA methylation, Hi-C, CRISPR/Cas9, dCas9-ED systems), her lab is discovering new molecular mechanisms of human diseases that can aid in the development of therapeutics to enhance quality of life for patients.
Research ORNG Applications Bibliographic
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TENET 2.0: Identification of key transcriptional regulators and enhancers in lung adenocarcinoma. PLoS Genet. 2020 09; 16(9):e1009023.
Mullen DJ, Yan C, Kang DS, Zhou B, Borok Z, Marconett CN, Farnham PJ, Offringa IA, Rhie SK. PMID: 32925947.
View in: PubMed Mentions: Fields: Translation: HumansCells
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Parallel PRC2/cPRC1 and vPRC1 pathways silence lineage-specific genes and maintain self-renewal in mouse embryonic stem cells. Sci Adv. 2020 04; 6(14):eaax5692.
Zepeda-Martinez JA, Pribitzer C, Wang J, Bsteh D, Golumbeanu S, Zhao Q, Burkard TR, Reichholf B, Rhie SK, Jude J, Moussa HF, Zuber J, Bell O. PMID: 32270030.
View in: PubMed Mentions: Fields: Translation: AnimalsCells
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Role of KCNAB2 expression in modulating hormone secretion in somatotroph pituitary adenoma. J Neurosurg. 2020 Feb 28; 1-7.
Ashton C, Rhie SK, Carmichael JD, Zada G. PMID: 32109873.
View in: PubMed Mentions: Fields:
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Epigenetic plasticity potentiates a rapid cyclical shift to and from an aggressive cancer phenotype. Int J Cancer. 2020 06 01; 146(11):3065-3076.
Xu T, Li HT, Wei J, Li M, Hsieh TC, Lu YT, Lakshminarasimhan R, Xu R, Hodara E, Morrison G, Gujar H, Rhie SK, Siegmund K, Liang G, Goldkorn A. PMID: 32017074.
View in: PubMed Mentions: Fields:
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A high-resolution 3D epigenomic map reveals insights into the creation of the prostate cancer transcriptome. Nat Commun. 2019 09 12; 10(1):4154.
Rhie SK, Perez AA, Lay FD, Schreiner S, Shi J, Polin J, Farnham PJ. PMID: 31515496.
View in: PubMed Mentions: 6 Fields: Translation: HumansCells
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The prostate cancer risk variant rs55958994 regulates multiple gene expression through extreme long-range chromatin interaction to control tumor progression. Sci Adv. 2019 07; 5(7):eaaw6710.
Qian Y, Zhang L, Cai M, Li H, Xu H, Yang H, Zhao Z, Rhie SK, Farnham PJ, Shi J, Lu W. PMID: 31328168.
View in: PubMed Mentions: 3 Fields: Translation: HumansCells
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Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner. Epigenetics Chromatin. 2019 05 03; 12(1):26.
O'Geen H, Bates SL, Carter SS, Nisson KA, Halmai J, Fink KD, Rhie SK, Farnham PJ, Segal DJ. PMID: 31053162.
View in: PubMed Mentions: 8 Fields: Translation: HumansAnimalsCells
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The Enigmatic HOX Genes: Can We Crack Their Code? Cancers (Basel). 2019 Mar 07; 11(3).
Luo Z, Rhie SK, Farnham PJ. PMID: 30866492.
View in: PubMed Mentions:
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Comprehensive functional genomic resource and integrative model for the human brain. Science. 2018 12 14; 362(6420).
Wang D, Liu S, Warrell J, Won H, Shi X, Navarro FCP, Clarke D, Gu M, Emani P, Yang YT, Xu M, Gandal MJ, Lou S, Zhang J, Park JJ, Yan C, Rhie SK, Manakongtreecheep K, Zhou H, Nathan A, Peters M, Mattei E, Fitzgerald D, Brunetti T, Moore J, Jiang Y, Girdhar K, Hoffman GE, Kalayci S, Gümüs ZH, Crawford GE, Roussos P, Akbarian S, Jaffe AE, White KP, Weng Z, Sestan N, Geschwind DH, Knowles JA, Gerstein MB. PMID: 30545857.
View in: PubMed Mentions: 80 Fields: Translation: HumansCells
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Transcriptome and epigenome landscape of human cortical development modeled in organoids. Science. 2018 12 14; 362(6420).
Amiri A, Coppola G, Scuderi S, Wu F, Roychowdhury T, Liu F, Pochareddy S, Shin Y, Safi A, Song L, Zhu Y, Sousa AMM, Gerstein M, Crawford GE, Sestan N, Abyzov A, Vaccarino FM. PMID: 30545853.
View in: PubMed Mentions: 41 Fields: Translation: HumansCells
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Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science. 2018 12 14; 362(6420).
Gandal MJ, Zhang P, Hadjimichael E, Walker RL, Chen C, Liu S, Won H, van Bakel H, Varghese M, Wang Y, Shieh AW, Haney J, Parhami S, Belmont J, Kim M, Moran Losada P, Khan Z, Mleczko J, Xia Y, Dai R, Wang D, Yang YT, Xu M, Fish K, Hof PR, Warrell J, Fitzgerald D, White K, Jaffe AE, Peters MA, Gerstein M, Liu C, Iakoucheva LM, Pinto D, Geschwind DH. PMID: 30545856.
View in: PubMed Mentions: 81 Fields: Translation: HumansCells
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Integrative functional genomic analysis of human brain development and neuropsychiatric risks. Science. 2018 12 14; 362(6420).
Li M, Santpere G, Imamura Kawasawa Y, Evgrafov OV, Gulden FO, Pochareddy S, Sunkin SM, Li Z, Shin Y, Zhu Y, Sousa AMM, Werling DM, Kitchen RR, Kang HJ, Pletikos M, Choi J, Muchnik S, Xu X, Wang D, Lorente-Galdos B, Liu S, Giusti-Rodríguez P, Won H, de Leeuw CA, Pardiñas AF, Hu M, Jin F, Li Y, Owen MJ, O'Donovan MC, Walters JTR, Posthuma D, Reimers MA, Levitt P, Weinberger DR, Hyde TM, Kleinman JE, Geschwind DH, Hawrylycz MJ, State MW, Sanders SJ, Sullivan PF, Gerstein MB, Lein ES, Knowles JA, Sestan N. PMID: 30545854.
View in: PubMed Mentions: 55 Fields: Translation: HumansCells
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Revealing the brain's molecular architecture. Science. 2018 Dec 14; 362(6420):1262-1263.
PMID: 30545881.
View in: PubMed Mentions: 3 Fields: Translation: HumansCells
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Using 3D epigenomic maps of primary olfactory neuronal cells from living individuals to understand gene regulation. Sci Adv. 2018 12; 4(12):eaav8550.
Rhie SK, Schreiner S, Witt H, Armoskus C, Lay FD, Camarena A, Spitsyna VN, Guo Y, Berman BP, Evgrafov OV, Knowles JA, Farnham PJ. PMID: 30555922.
View in: PubMed Mentions: 8 Fields: Translation: HumansCells
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CRISPR-mediated deletion of prostate cancer risk-associated CTCF loop anchors identifies repressive chromatin loops. Genome Biol. 2018 10 08; 19(1):160.
Guo Y, Perez AA, Hazelett DJ, Coetzee GA, Rhie SK, Farnham PJ. PMID: 30296942.
View in: PubMed Mentions: 9 Fields: Translation: HumansCells
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Positional integration of lung adenocarcinoma susceptibility loci with primary human alveolar epithelial cell epigenomes. Epigenomics. 2018 09; 10(9):1167-1187.
Yang C, Stueve TR, Yan C, Rhie SK, Mullen DJ, Luo J, Zhou B, Borok Z, Marconett CN, Offringa IA. PMID: 30212242.
View in: PubMed Mentions: 2 Fields: Translation: HumansCells
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ZFX acts as a transcriptional activator in multiple types of human tumors by binding downstream of transcription start sites at the majority of CpG island promoters. Genome Res. 2018 Feb 02.
PMID: 29429977.
View in: PubMed Mentions: 6 Fields:
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Defining Regulatory Elements in the Human Genome Using Nucleosome Occupancy and Methylome Sequencing (NOMe-Seq). Methods Mol Biol. 2018; 1766:209-229.
Rhie SK, Schreiner S, Farnham PJ. PMID: 29605855.
View in: PubMed Mentions: 1 Fields: Translation: HumansCells
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Comparison of Breast Cancer Molecular Features and Survival by African and European Ancestry in The Cancer Genome Atlas. JAMA Oncol. 2017 12 01; 3(12):1654-1662.
Huo D, Hu H, Rhie SK, Gamazon ER, Cherniack AD, Liu J, Yoshimatsu TF, Pitt JJ, Hoadley KA, Troester M, Ru Y, Lichtenberg T, Sturtz LA, Shelley CS, Benz CC, Mills GB, Laird PW, Shriver CD, Perou CM, Olopade OI. PMID: 28472234.
View in: PubMed Mentions: 46 Fields: Translation: Humans
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A Prostate Cancer Risk Element Functions as a Repressive Loop that Regulates HOXA13. Cell Rep. 2017 Nov 07; 21(6):1411-1417.
Luo Z, Rhie SK, Lay FD, Farnham PJ. PMID: 29117547.
View in: PubMed Mentions: 9 Fields: Translation: HumansCells
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Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles. Cell Rep. 2017 06 27; 19(13):2878-2880.
Farshidfar F, Zheng S, Gingras MC, Newton Y, Shih J, Robertson AG, Hinoue T, Hoadley KA, Gibb EA, Roszik J, Covington KR, Wu CC, Shinbrot E, Stransky N, Hegde A, Yang JD, Reznik E, Sadeghi S, Pedamallu CS, Ojesina AI, Hess JM, Auman JT, Rhie SK, Bowlby R, Borad MJ, Zhu AX, Stuart JM, Sander C, Akbani R, Cherniack AD, Deshpande V, Mounajjed T, Foo WC, Torbenson MS, Kleiner DE, Laird PW, Wheeler DA, McRee AJ, Bathe OF, Andersen JB, Bardeesy N, Roberts LR, Kwong LN. PMID: 28658632.
View in: PubMed Mentions: 30 Fields:
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Characterizing Genetic Susceptibility to Breast Cancer in Women of African Ancestry. Cancer Epidemiol Biomarkers Prev. 2017 07; 26(7):1016-1026.
PMID: 28377418.
View in: PubMed Mentions: 5 Fields: Translation: Humans
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Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles. Cell Rep. 2017 03 14; 18(11):2780-2794.
PMID: 28297679.
View in: PubMed Mentions: 61 Fields: Translation: HumansCells
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Identification of activated enhancers and linked transcription factors in breast, prostate, and kidney tumors by tracing enhancer networks using epigenetic traits. Epigenetics Chromatin. 2016; 9:50.
PMID: 27833659.
View in: PubMed Mentions: 18 Fields: Translation: HumansCells
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The Molecular Taxonomy of Primary Prostate Cancer. Cell. 2015 Nov 05; 163(4):1011-25.
PMID: 26544944.
View in: PubMed Mentions: 626 Fields: Translation: HumansCells
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Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer. Cell. 2015 Oct 08; 163(2):506-19.
PMID: 26451490.
View in: PubMed Mentions: 459 Fields: Translation: HumansCells
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Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci. Hum Mol Genet. 2015 Jul 01; 24(13):3595-607.
PMID: 25804953.
View in: PubMed Mentions: 15 Fields: Translation: HumansCells
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Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. Cell. 2014 Aug 14; 158(4):929-944.
PMID: 25109877.
View in: PubMed Mentions: 409 Fields: Translation: HumansCells
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A comprehensive examination of breast cancer risk loci in African American women. Hum Mol Genet. 2014 Oct 15; 23(20):5518-26.
PMID: 24852375.
View in: PubMed Mentions: 18 Fields: Translation: Humans
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Nucleosome positioning and histone modifications define relationships between regulatory elements and nearby gene expression in breast epithelial cells. BMC Genomics. 2014 May 02; 15:331.
PMID: 24885402.
View in: PubMed Mentions: 23 Fields: Translation: HumansCells
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Comprehensive functional annotation of 77 prostate cancer risk loci. PLoS Genet. 2014 Jan; 10(1):e1004102.
PMID: 24497837.
View in: PubMed Mentions: 69 Fields: Translation: HumansCells
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The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet. 2013 Oct; 45(10):1113-20.
PMID: 24071849.
View in: PubMed Mentions: 1448 Fields: Translation: Humans
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Comprehensive functional annotation of seventy-one breast cancer risk Loci. PLoS One. 2013; 8(5):e63925.
PMID: 23717510.
View in: PubMed Mentions: 30 Fields: Translation: HumansCells
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A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet. 2013 Jun; 45(6):690-6.
PMID: 23583978.
View in: PubMed Mentions: 110 Fields: Translation: Humans
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Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet. 2013 Apr; 45(4):392-8, 398e1-2.
PMID: 23535733.
View in: PubMed Mentions: 216 Fields: Translation: Humans
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A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11. Hum Mol Genet. 2012 Dec 15; 21(24):5373-84.
PMID: 22976474.
View in: PubMed Mentions: 107 Fields: Translation: Humans
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A genome-wide association study of breast cancer in women of African ancestry. Hum Genet. 2013 Jan; 132(1):39-48.
PMID: 22923054.
View in: PubMed Mentions: 40 Fields: Translation: Humans
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FunciSNP: an R/bioconductor tool integrating functional non-coding data sets with genetic association studies to identify candidate regulatory SNPs. Nucleic Acids Res. 2012 Oct; 40(18):e139.
PMID: 22684628.
View in: PubMed Mentions: 58 Fields: Translation: HumansCells
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Myogenic Akt signaling upregulates the utrophin-glycoprotein complex and promotes sarcolemma stability in muscular dystrophy. Hum Mol Genet. 2009 Jan 15; 18(2):318-27.
Peter AK, Ko CY, Kim MH, Hsu N, Ouchi N, Rhie S, Izumiya Y, Zeng L, Walsh K, Crosbie RH. PMID: 18986978.
View in: PubMed Mentions: 23 Fields: Translation: HumansAnimalsCells
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A case of pulmonary cysticercosis. Korean J Intern Med. 1991 Jan; 6(1):38-43.
Choi JH, Chung SI, Whang YS, Lee JD, Lim HO, Choi JH, Chang SH, Jung KM, Rhie S. PMID: 1742255.
View in: PubMed Mentions: Fields: Translation: Humans
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Year | Publications |
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1991 | 1 | 2008 | 1 | 2012 | 3 | 2013 | 4 | 2014 | 4 | 2015 | 3 | 2016 | 1 | 2017 | 5 | 2018 | 10 | 2019 | 4 | 2020 | 4 |
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Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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