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Suhn Kyong Rhie

Title(s)Assistant Professor of Biochemistry and Molecular Medicine
Address1450 Biggy Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 8145
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    Collapse Biography 
    Collapse Education and Training
    University of California, Los AngelesB.S.06/2007Biochemistry
    University of Southern CaliforniaPh.D.05/2013Genetic, Molecular and Cellular Biology
    Collapse Awards and Honors
    2018  - 2021NCI Career Development Award
    2007Women for Change
    2007Ethel Terry McCoy Award for Excellence in Chemistry and Biochemistry

    Collapse Overview 
    Collapse Overview
    Dr. Rhie received her B.S. in Biochemistry, magna cum laude from the University of California, Los Angeles. She earned her Ph.D. degree in Genetic, Molecular and Cellular Biology from the University of Southern California in 2013. She completed her postdoctoral training in the laboratories of Dr. Peter Laird and Dr. Peggy Farnham. Dr. Rhie participated in Genome-Wide Association Studies (GWAS) in different cancer types, unraveling mechanisms that explain how genetic variants affect disease risks. Dr. Rhie characterized heterogeneous tumor tissues as a leader of DNA methylation analysis for The Cancer Genome Atlas (TCGA) Consortium and discovered how genetic alterations such as somatic mutations, fusions, copy number variations are associated with epigenetic changes in cancer. She has also led epigenomic data analysis to investigate how transcription factors act at regulatory elements in a 3D nucleome structure in cancer and psychiatric diseases as part of the ENCODE and PsychENCODE Consortia.
    Her current research interests are to characterize key transcription factor and understand roles of regulatory elements activated in different types of cancers and neurodevelopmental diseases. By using both molecular biology and bioinformatics to address how genes are regulated in 3D nucleome structure (e.g. ChIP-seq, RNA-seq, whole genome sequencing, whole genome bisulfite sequencing, NOMe-seq, DNA methylation, Hi-C, CRISPR/Cas9, dCas9-ED systems), her lab is discovering new molecular mechanisms of human diseases that can aid in the development of therapeutics to enhance quality of life for patients.

    Collapse Research 
    Collapse Research Activities and Funding
    Identification and Clinical Validation of Key Transcription Factor Isoforms Linked to Breast and Prostate Cancer Subgroups using Epigenetic Traits
    NIH/NCI K01CA229995Sep 1, 2018 - Aug 31, 2021
    Role: Principal Investigator
    Identification and Clinical Validation of Key Transcription Factor Isoforms Linked to Breast and Prostate Cancer Subgroups using Epigenetic Traits
    NIH K01CA229995Sep 1, 2018 - Aug 31, 2021
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. TENET 2.0: Identification of key transcriptional regulators and enhancers in lung adenocarcinoma. PLoS Genet. 2020 09; 16(9):e1009023. Mullen DJ, Yan C, Kang DS, Zhou B, Borok Z, Marconett CN, Farnham PJ, Offringa IA, Rhie SK. PMID: 32925947.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Parallel PRC2/cPRC1 and vPRC1 pathways silence lineage-specific genes and maintain self-renewal in mouse embryonic stem cells. Sci Adv. 2020 04; 6(14):eaax5692. Zepeda-Martinez JA, Pribitzer C, Wang J, Bsteh D, Golumbeanu S, Zhao Q, Burkard TR, Reichholf B, Rhie SK, Jude J, Moussa HF, Zuber J, Bell O. PMID: 32270030.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Role of KCNAB2 expression in modulating hormone secretion in somatotroph pituitary adenoma. J Neurosurg. 2020 Feb 28; 1-7. Ashton C, Rhie SK, Carmichael JD, Zada G. PMID: 32109873.
      View in: PubMed   Mentions:    Fields:    
    4. Epigenetic plasticity potentiates a rapid cyclical shift to and from an aggressive cancer phenotype. Int J Cancer. 2020 06 01; 146(11):3065-3076. Xu T, Li HT, Wei J, Li M, Hsieh TC, Lu YT, Lakshminarasimhan R, Xu R, Hodara E, Morrison G, Gujar H, Rhie SK, Siegmund K, Liang G, Goldkorn A. PMID: 32017074.
      View in: PubMed   Mentions:    Fields:    
    5. A high-resolution 3D epigenomic map reveals insights into the creation of the prostate cancer transcriptome. Nat Commun. 2019 09 12; 10(1):4154. Rhie SK, Perez AA, Lay FD, Schreiner S, Shi J, Polin J, Farnham PJ. PMID: 31515496.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    6. The prostate cancer risk variant rs55958994 regulates multiple gene expression through extreme long-range chromatin interaction to control tumor progression. Sci Adv. 2019 07; 5(7):eaaw6710. Qian Y, Zhang L, Cai M, Li H, Xu H, Yang H, Zhao Z, Rhie SK, Farnham PJ, Shi J, Lu W. PMID: 31328168.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    7. Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner. Epigenetics Chromatin. 2019 05 03; 12(1):26. O'Geen H, Bates SL, Carter SS, Nisson KA, Halmai J, Fink KD, Rhie SK, Farnham PJ, Segal DJ. PMID: 31053162.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    8. The Enigmatic HOX Genes: Can We Crack Their Code? Cancers (Basel). 2019 Mar 07; 11(3). Luo Z, Rhie SK, Farnham PJ. PMID: 30866492.
      View in: PubMed   Mentions:
    9. Comprehensive functional genomic resource and integrative model for the human brain. Science. 2018 12 14; 362(6420). Wang D, Liu S, Warrell J, Won H, Shi X, Navarro FCP, Clarke D, Gu M, Emani P, Yang YT, Xu M, Gandal MJ, Lou S, Zhang J, Park JJ, Yan C, Rhie SK, Manakongtreecheep K, Zhou H, Nathan A, Peters M, Mattei E, Fitzgerald D, Brunetti T, Moore J, Jiang Y, Girdhar K, Hoffman GE, Kalayci S, Gümüs ZH, Crawford GE, Roussos P, Akbarian S, Jaffe AE, White KP, Weng Z, Sestan N, Geschwind DH, Knowles JA, Gerstein MB. PMID: 30545857.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    10. Transcriptome and epigenome landscape of human cortical development modeled in organoids. Science. 2018 12 14; 362(6420). Amiri A, Coppola G, Scuderi S, Wu F, Roychowdhury T, Liu F, Pochareddy S, Shin Y, Safi A, Song L, Zhu Y, Sousa AMM, Gerstein M, Crawford GE, Sestan N, Abyzov A, Vaccarino FM. PMID: 30545853.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    11. Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science. 2018 12 14; 362(6420). Gandal MJ, Zhang P, Hadjimichael E, Walker RL, Chen C, Liu S, Won H, van Bakel H, Varghese M, Wang Y, Shieh AW, Haney J, Parhami S, Belmont J, Kim M, Moran Losada P, Khan Z, Mleczko J, Xia Y, Dai R, Wang D, Yang YT, Xu M, Fish K, Hof PR, Warrell J, Fitzgerald D, White K, Jaffe AE, Peters MA, Gerstein M, Liu C, Iakoucheva LM, Pinto D, Geschwind DH. PMID: 30545856.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    12. Integrative functional genomic analysis of human brain development and neuropsychiatric risks. Science. 2018 12 14; 362(6420). Li M, Santpere G, Imamura Kawasawa Y, Evgrafov OV, Gulden FO, Pochareddy S, Sunkin SM, Li Z, Shin Y, Zhu Y, Sousa AMM, Werling DM, Kitchen RR, Kang HJ, Pletikos M, Choi J, Muchnik S, Xu X, Wang D, Lorente-Galdos B, Liu S, Giusti-Rodríguez P, Won H, de Leeuw CA, Pardiñas AF, Hu M, Jin F, Li Y, Owen MJ, O'Donovan MC, Walters JTR, Posthuma D, Reimers MA, Levitt P, Weinberger DR, Hyde TM, Kleinman JE, Geschwind DH, Hawrylycz MJ, State MW, Sanders SJ, Sullivan PF, Gerstein MB, Lein ES, Knowles JA, Sestan N. PMID: 30545854.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    13. Revealing the brain's molecular architecture. Science. 2018 Dec 14; 362(6420):1262-1263. PMID: 30545881.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    14. Using 3D epigenomic maps of primary olfactory neuronal cells from living individuals to understand gene regulation. Sci Adv. 2018 12; 4(12):eaav8550. Rhie SK, Schreiner S, Witt H, Armoskus C, Lay FD, Camarena A, Spitsyna VN, Guo Y, Berman BP, Evgrafov OV, Knowles JA, Farnham PJ. PMID: 30555922.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    15. CRISPR-mediated deletion of prostate cancer risk-associated CTCF loop anchors identifies repressive chromatin loops. Genome Biol. 2018 10 08; 19(1):160. Guo Y, Perez AA, Hazelett DJ, Coetzee GA, Rhie SK, Farnham PJ. PMID: 30296942.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    16. Positional integration of lung adenocarcinoma susceptibility loci with primary human alveolar epithelial cell epigenomes. Epigenomics. 2018 09; 10(9):1167-1187. Yang C, Stueve TR, Yan C, Rhie SK, Mullen DJ, Luo J, Zhou B, Borok Z, Marconett CN, Offringa IA. PMID: 30212242.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    17. ZFX acts as a transcriptional activator in multiple types of human tumors by binding downstream of transcription start sites at the majority of CpG island promoters. Genome Res. 2018 Feb 02. PMID: 29429977.
      View in: PubMed   Mentions: 6     Fields:    
    18. Defining Regulatory Elements in the Human Genome Using Nucleosome Occupancy and Methylome Sequencing (NOMe-Seq). Methods Mol Biol. 2018; 1766:209-229. Rhie SK, Schreiner S, Farnham PJ. PMID: 29605855.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    19. Comparison of Breast Cancer Molecular Features and Survival by African and European Ancestry in The Cancer Genome Atlas. JAMA Oncol. 2017 12 01; 3(12):1654-1662. Huo D, Hu H, Rhie SK, Gamazon ER, Cherniack AD, Liu J, Yoshimatsu TF, Pitt JJ, Hoadley KA, Troester M, Ru Y, Lichtenberg T, Sturtz LA, Shelley CS, Benz CC, Mills GB, Laird PW, Shriver CD, Perou CM, Olopade OI. PMID: 28472234.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    20. A Prostate Cancer Risk Element Functions as a Repressive Loop that Regulates HOXA13. Cell Rep. 2017 Nov 07; 21(6):1411-1417. Luo Z, Rhie SK, Lay FD, Farnham PJ. PMID: 29117547.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    21. Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles. Cell Rep. 2017 06 27; 19(13):2878-2880. Farshidfar F, Zheng S, Gingras MC, Newton Y, Shih J, Robertson AG, Hinoue T, Hoadley KA, Gibb EA, Roszik J, Covington KR, Wu CC, Shinbrot E, Stransky N, Hegde A, Yang JD, Reznik E, Sadeghi S, Pedamallu CS, Ojesina AI, Hess JM, Auman JT, Rhie SK, Bowlby R, Borad MJ, Zhu AX, Stuart JM, Sander C, Akbani R, Cherniack AD, Deshpande V, Mounajjed T, Foo WC, Torbenson MS, Kleiner DE, Laird PW, Wheeler DA, McRee AJ, Bathe OF, Andersen JB, Bardeesy N, Roberts LR, Kwong LN. PMID: 28658632.
      View in: PubMed   Mentions: 30     Fields:    
    22. Characterizing Genetic Susceptibility to Breast Cancer in Women of African Ancestry. Cancer Epidemiol Biomarkers Prev. 2017 07; 26(7):1016-1026. PMID: 28377418.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    23. Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles. Cell Rep. 2017 03 14; 18(11):2780-2794. PMID: 28297679.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    24. Identification of activated enhancers and linked transcription factors in breast, prostate, and kidney tumors by tracing enhancer networks using epigenetic traits. Epigenetics Chromatin. 2016; 9:50. PMID: 27833659.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    25. The Molecular Taxonomy of Primary Prostate Cancer. Cell. 2015 Nov 05; 163(4):1011-25. PMID: 26544944.
      View in: PubMed   Mentions: 626     Fields:    Translation:HumansCells
    26. Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer. Cell. 2015 Oct 08; 163(2):506-19. PMID: 26451490.
      View in: PubMed   Mentions: 459     Fields:    Translation:HumansCells
    27. Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci. Hum Mol Genet. 2015 Jul 01; 24(13):3595-607. PMID: 25804953.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    28. Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. Cell. 2014 Aug 14; 158(4):929-944. PMID: 25109877.
      View in: PubMed   Mentions: 409     Fields:    Translation:HumansCells
    29. A comprehensive examination of breast cancer risk loci in African American women. Hum Mol Genet. 2014 Oct 15; 23(20):5518-26. PMID: 24852375.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    30. Nucleosome positioning and histone modifications define relationships between regulatory elements and nearby gene expression in breast epithelial cells. BMC Genomics. 2014 May 02; 15:331. PMID: 24885402.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    31. Comprehensive functional annotation of 77 prostate cancer risk loci. PLoS Genet. 2014 Jan; 10(1):e1004102. PMID: 24497837.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    32. The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet. 2013 Oct; 45(10):1113-20. PMID: 24071849.
      View in: PubMed   Mentions: 1448     Fields:    Translation:Humans
    33. Comprehensive functional annotation of seventy-one breast cancer risk Loci. PLoS One. 2013; 8(5):e63925. PMID: 23717510.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    34. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet. 2013 Jun; 45(6):690-6. PMID: 23583978.
      View in: PubMed   Mentions: 110     Fields:    Translation:Humans
    35. Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet. 2013 Apr; 45(4):392-8, 398e1-2. PMID: 23535733.
      View in: PubMed   Mentions: 216     Fields:    Translation:Humans
    36. A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11. Hum Mol Genet. 2012 Dec 15; 21(24):5373-84. PMID: 22976474.
      View in: PubMed   Mentions: 107     Fields:    Translation:Humans
    37. A genome-wide association study of breast cancer in women of African ancestry. Hum Genet. 2013 Jan; 132(1):39-48. PMID: 22923054.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    38. FunciSNP: an R/bioconductor tool integrating functional non-coding data sets with genetic association studies to identify candidate regulatory SNPs. Nucleic Acids Res. 2012 Oct; 40(18):e139. PMID: 22684628.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    39. Myogenic Akt signaling upregulates the utrophin-glycoprotein complex and promotes sarcolemma stability in muscular dystrophy. Hum Mol Genet. 2009 Jan 15; 18(2):318-27. Peter AK, Ko CY, Kim MH, Hsu N, Ouchi N, Rhie S, Izumiya Y, Zeng L, Walsh K, Crosbie RH. PMID: 18986978.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    40. A case of pulmonary cysticercosis. Korean J Intern Med. 1991 Jan; 6(1):38-43. Choi JH, Chung SI, Whang YS, Lee JD, Lim HO, Choi JH, Chang SH, Jung KM, Rhie S. PMID: 1742255.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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