Loading...

Kimberly Siegmund, PhD

Title(s)Professor of Preventive Medicine
AddressSSB 202W 2001 N. Soto Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 1310
vCardDownload vCard

    Collapse Overview 
    Collapse Overview
    Dr. Siegmund is a biostatistician with expertise in cancer modeling and the statistical analysis of epigenetic data in human disease. She has published numerous papers studying DNA methylation, and teaches a course on the statistical analysis of high-dimensional data. Her current research focuses on developing mathematical models to understand the growth and spread of cancer. These models address fundamental questions about aging through modeling cell division processes from a molecular phylogenetic approach.

    Dr. Siegmund is interested the analysis of DNA methylation and gene expression data. She is developing mathematical models that will allow the identification of disease sub-types based on DNA methylation profiles. Other interests and skills relate to the design and analysis of family studies for gene characterization.

    Collapse Research 
    Collapse Research Activities and Funding
    LA?s Biostatistics Education Summer Training Program (LA?s BEST @USC)
    NIH/NHLBI R25HL147236Mar 15, 2019 - Feb 28, 2022
    Role: Co-Principal Investigator
    Statistical Analysis of Epigenomics Data
    NIH/NHGRI R01HG006705Mar 26, 2013 - Feb 29, 2016
    Role: Principal Investigator
    Applying Molecular Phylogeny to Predict Clinical Outcomes in Cancer
    NIH/NCI R21CA151139Sep 1, 2010 - Aug 31, 2013
    Role: Principal Investigator
    Statistical Models in Epigenomics
    NIH/NCI R01CA097346Jul 1, 2002 - Jun 30, 2014
    Role: Principal Investigator
    Statistical Models in Epigenomics
    NIH/NCI R56CA097346Jul 1, 2002 - Jun 30, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Epigenetic plasticity potentiates a rapid cyclical shift to and from an aggressive cancer phenotype. Int J Cancer. 2020 Jun 01; 146(11):3065-3076. Xu T, Li HT, Wei J, Li M, Hsieh TC, Lu YT, Lakshminarasimhan R, Xu R, Hodara E, Morrison G, Gujar H, Rhie SK, Siegmund K, Liang G, Goldkorn A. PMID: 32017074.
      View in: PubMed   Mentions:    Fields:    
    2. Epigenetic Conservation Is a Beacon of Function: An Analysis Using Methcon5 Software for Studying Gene Methylation. JCO Clin Cancer Inform. 2020 02; 4:100-107. Hvitfeldt E, Xia C, Siegmund KD, Shibata D, Marjoram P. PMID: 32078366.
      View in: PubMed   Mentions:    Fields:    
    3. Mutational signatures in colon cancer. BMC Res Notes. 2019 Dec 03; 12(1):788. Pandey P, Yang Z, Shibata D, Marjoram P, Siegmund KD. PMID: 31796096.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. HiLDA: a statistical approach to investigate differences in mutational signatures. PeerJ. 2019; 7:e7557. Yang Z, Pandey P, Shibata D, Conti DV, Marjoram P, Siegmund KD. PMID: 31523512.
      View in: PubMed   Mentions:
    5. Systematic Review and Meta-analysis of Testicular Germ Cell Tumors Following In Utero Exposure to Diethylstilbestrol. JNCI Cancer Spectr. 2019 Sep; 3(3):pkz045. Hom M, Sriprasert I, Ihenacho U, Castelao JE, Siegmund K, Bernstein L, Cortessis VK. PMID: 31555759.
      View in: PubMed   Mentions:
    6. Deregulation of Biologically Significant Genes and Associated Molecular Pathways in the Oral Epithelium of Electronic Cigarette Users. Int J Mol Sci. 2019 Feb 10; 20(3). Tommasi S, Caliri AW, Caceres A, Moreno DE, Li M, Chen Y, Siegmund KD, Besaratinia A. PMID: 30744164.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. DNA methylation patterns of adult survivors of adolescent/young adult Hodgkin lymphoma compared to their unaffected monozygotic twin. Leuk Lymphoma. 2019 06; 60(6):1429-1437. Wang J, Van Den Berg D, Hwang AE, Weisenberger D, Triche T, Nathwani BN, Conti DV, Siegmund K, Mack TM, Horvath S, Cozen W. PMID: 30668190.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. Epigenetic Heterogeneity in Human Colorectal Tumors Reveals Preferential Conservation And Evidence of Immune Surveillance. Sci Rep. 2018 11 23; 8(1):17292. Ryser MD, Yu M, Grady W, Siegmund K, Shibata D. PMID: 30470817.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    9. Association between AXL promoter methylation and lung function growth during adolescence. Epigenetics. 2018; 13(10-11):1027-1038. Gao L, Urman R, Millstein J, Siegmund KD, Dubeau L, Breton CV. PMID: 30277126.
      View in: PubMed   Mentions:    Fields:    
    10. Data integration by multi-tuning parameter elastic net regression. BMC Bioinformatics. 2018 Oct 10; 19(1):369. Liu J, Liang G, Siegmund KD, Lewinger JP. PMID: 30305021.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Association of internal smoking dose with blood DNA methylation in three racial/ethnic populations. Clin Epigenetics. 2018 08 23; 10(1):110. Park SL, Patel YM, Loo LWM, Mullen DJ, Offringa IA, Maunakea A, Stram DO, Siegmund K, Murphy SE, Tiirikainen M, Le Marchand L. PMID: 30139389.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    12. Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes. Clin Epigenetics. 2018 07 20; 10(1):98. Gao L, Liu X, Millstein J, Siegmund KD, Dubeau L, Maguire RL, Jim Zhang J, Fuemmeler BF, Kollins SH, Hoyo C, Murphy SK, Breton CV. PMID: 30029617.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. Spatial mutation patterns as markers of early colorectal tumor cell mobility. Proc Natl Acad Sci U S A. 2018 05 29; 115(22):5774-5779. Ryser MD, Min BH, Siegmund KD, Shibata D. PMID: 29760052.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    14. Comprehensive meta-analysis reveals association between multiple imprinting disorders and conception by assisted reproductive technology. J Assist Reprod Genet. 2018 Jun; 35(6):943-952. Cortessis VK, Azadian M, Buxbaum J, Sanogo F, Song AY, Sriprasert I, Wei PC, Yu J, Chung K, Siegmund KD. PMID: 29696471.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    15. Total Outflow Facility in Live C57BL/6 Mice of Different Age. Biomed Hub. 2017 Sep-Dec; 2(3):1-10. Yelenskiy A, Ko MK, Chu ER, Gonzalez JM, Siegmund K, Tan JC. PMID: 31988919.
      View in: PubMed   Mentions:
    16. Epigenetic regulation of AXL and risk of childhood asthma symptoms. Clin Epigenetics. 2017; 9:121. Gao L, Millstein J, Siegmund KD, Dubeau L, Maguire R, Gilliland FD, Murphy SK, Hoyo C, Breton CV. PMID: 29177020.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    17. Impact of Chromosomal Rearrangement upon DNA Methylation Patterns in Leukemia. Open Med (Wars). 2017; 12:76-85. Byun HM, Eshaghian S, Douer D, Trent J, Garcia-Manero G, Bhatia R, Siegmund K, Yang AS. PMID: 28730166.
      View in: PubMed   Mentions:
    18. Early mutation bursts in colorectal tumors. PLoS One. 2017; 12(3):e0172516. Zhao J, Salomon MP, Shibata D, Curtis C, Siegmund K, Marjoram P. PMID: 28257429.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    19. Cross-Species Transcriptome Profiling Identifies New Alveolar Epithelial Type I Cell-Specific Genes. Am J Respir Cell Mol Biol. 2017 03; 56(3):310-321. Marconett CN, Zhou B, Sunohara M, Pouldar TM, Wang H, Liu Y, Rieger ME, Tran E, Flodby P, Siegmund KD, Crandall ED, Laird-Offringa IA, Borok Z. PMID: 27749084.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    20. Improving needle biopsy accuracy in small renal mass using tumor-specific DNA methylation markers. Oncotarget. 2017 Jan 17; 8(3):5439-5448. Chopra S, Liu J, Alemozaffar M, Nichols PW, Aron M, Weisenberger DJ, Collings CK, Syan S, Hu B, Desai M, Aron M, Duddalwar V, Gill I, Liang G, Siegmund KD. PMID: 27690297.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    21. Identifying aggressive prostate cancer foci using a DNA methylation classifier. Genome Biol. 2017 01 12; 18(1):3. Mundbjerg K, Chopra S, Alemozaffar M, Duymich C, Lakshminarasimhan R, Nichols PW, Aron M, Siegmund KD, Ukimura O, Aron M, Stern M, Gill P, Carpten JD, Ørntoft TF, Sørensen KD, Weisenberger DJ, Jones PA, Duddalwar V, Gill I, Liang G. PMID: 28081708.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    22. Genetic complexity at expression quantitative trait loci. BMC Proc. 2016; 10(Suppl 7):85-89. Cantor RM, Pan C, Siegmund K. PMID: 27980616.
      View in: PubMed   Mentions:
    23. An evaluation of processing methods for HumanMethylation450 BeadChip data. BMC Genomics. 2016 06 22; 17:469. Liu J, Siegmund KD. PMID: 27334613.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    24. Particulate matter, the newborn methylome, and cardio-respiratory health outcomes in childhood. Environ Epigenet. 2016 Apr; 2(2):dvw005. Breton CV, Gao L, Yao J, Siegmund KD, Lurmann F, Gilliland F. PMID: 29492287.
      View in: PubMed   Mentions:
    25. Prenatal Air Pollution Exposures, DNA Methyl Transferase Genotypes, and Associations with Newborn LINE1 and Alu Methylation and Childhood Blood Pressure and Carotid Intima-Media Thickness in the Children's Health Study. Environ Health Perspect. 2016 12; 124(12):1905-1912. Breton CV, Yao J, Millstein J, Gao L, Siegmund KD, Mack W, Whitfield-Maxwell L, Lurmann F, Hodis H, Avol E, Gilliland FD. PMID: 27219456.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    26. At least two well-spaced samples are needed to genotype a solid tumor. BMC Cancer. 2016 Mar 25; 16:250. Siegmund K, Shibata D. PMID: 27015839.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    27. Identification of DNA Methylation-Independent Epigenetic Events Underlying Clear Cell Renal Cell Carcinoma. Cancer Res. 2016 04 01; 76(7):1954-64. Becket E, Chopra S, Duymich CE, Lin JJ, You JS, Pandiyan K, Nichols PW, Siegmund KD, Charlet J, Weisenberger DJ, Jones PA, Liang G. PMID: 26759245.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    28. Many private mutations originate from the first few divisions of a human colorectal adenoma. J Pathol. 2015 Nov; 237(3):355-62. Kang H, Salomon MP, Sottoriva A, Zhao J, Toy M, Press MF, Curtis C, Marjoram P, Siegmund K, Shibata D. PMID: 26119426.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    29. Identifying differential transcription factor binding in ChIP-seq. Front Genet. 2015; 6:169. Wu DY, Bittencourt D, Stallcup MR, Siegmund KD. PMID: 25972895.
      View in: PubMed   Mentions:
    30. A Big Bang model of human colorectal tumor growth. Nat Genet. 2015 Mar; 47(3):209-16. Sottoriva A, Kang H, Ma Z, Graham TA, Salomon MP, Zhao J, Marjoram P, Siegmund K, Press MF, Shibata D, Curtis C. PMID: 25665006.
      View in: PubMed   Mentions: 216     Fields:    Translation:Humans
    31. Association of the colorectal CpG island methylator phenotype with molecular features, risk factors, and family history. Cancer Epidemiol Biomarkers Prev. 2015 Mar; 24(3):512-519. Weisenberger DJ, Levine AJ, Long TI, Buchanan DD, Walters R, Clendenning M, Rosty C, Joshi AD, Stern MC, LeMarchand L, Lindor NM, Daftary D, Gallinger S, Selander T, Bapat B, Newcomb PA, Campbell PT, Casey G, Ahnen DJ, Baron JA, Haile RW, Hopper JL, Young JP, Laird PW, Siegmund KD. PMID: 25587051.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    32. Transcriptomic Profiling of Primary Alveolar Epithelial Cell Differentiation in Human and Rat. Genom Data. 2014 Dec 01; 2:105-109. Marconett CN, Zhou B, Siegmund KD, Borok Z, Laird-Offringa IA. PMID: 25343132.
      View in: PubMed   Mentions:
    33. Distinct, genome-wide, gene-specific selectivity patterns of four glucocorticoid receptor coregulators. Nucl Recept Signal. 2014; 12:e002. Wu DY, Ou CY, Chodankar R, Siegmund KD, Stallcup MR. PMID: 25422592.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    34. Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation. PLoS One. 2014; 9(6):e99716. Breton CV, Siegmund KD, Joubert BR, Wang X, Qui W, Carey V, Nystad W, Håberg SE, Ober C, Nicolae D, Barnes KC, Martinez F, Liu A, Lemanske R, Strunk R, Weiss S, London S, Gilliland F, Raby B. PMID: 24964093.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    35. Non-specific filtering of beta-distributed data. BMC Bioinformatics. 2014 Jun 19; 15:199. Wang X, Laird PW, Hinoue T, Groshen S, Siegmund KD. PMID: 24943962.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    36. Ancestral inference in tumors: how much can we know? J Theor Biol. 2014 Oct 21; 359:136-45. Zhao J, Siegmund KD, Shibata D, Marjoram P. PMID: 24907673.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    37. A panel of three markers hyper- and hypomethylated in urine sediments accurately predicts bladder cancer recurrence. Clin Cancer Res. 2014 Apr 01; 20(7):1978-89. Su SF, de Castro Abreu AL, Chihara Y, Tsai Y, Andreu-Vieyra C, Daneshmand S, Skinner EC, Jones PA, Siegmund KD, Liang G. PMID: 24691641.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    38. NOS1 methylation and carotid artery intima-media thickness in children. Circ Cardiovasc Genet. 2014 Apr; 7(2):116-22. Breton CV, Park C, Siegmund K, Gauderman WJ, Whitfield-Maxwell L, Hodis HN, Avol E, Gilliland FD. PMID: 24622112.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    39. Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue. Nat Commun. 2014 Feb 27; 5:3365. Shi J, Marconett CN, Duan J, Hyland PL, Li P, Wang Z, Wheeler W, Zhou B, Campan M, Lee DS, Huang J, Zhou W, Triche T, Amundadottir L, Warner A, Hutchinson A, Chen PH, Chung BS, Pesatori AC, Consonni D, Bertazzi PA, Bergen AW, Freedman M, Siegmund KD, Berman BP, Borok Z, Chatterjee N, Tucker MA, Caporaso NE, Chanock SJ, Laird-Offringa IA, Landi MT. PMID: 24572595.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    40. Recommendations for the design and analysis of epigenome-wide association studies. Nat Methods. 2013 Oct; 10(10):949-55. Michels KB, Binder AM, Dedeurwaerder S, Epstein CB, Greally JM, Gut I, Houseman EA, Izzi B, Kelsey KT, Meissner A, Milosavljevic A, Siegmund KD, Bock C, Irizarry RA. PMID: 24076989.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansAnimalsCells
    41. Null association between histology of first and second primary malignancies in men with bilateral testicular germ cell tumors. Am J Epidemiol. 2013 Oct 15; 178(8):1240-5. Thomas JP, Davis-Dao C, Lewinger JP, Siegmund KD, Hamilton AS, Daneshmand S, Skinner EC, Thomas DC, Cortessis VK. PMID: 23928263.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    42. Integrated transcriptomic and epigenomic analysis of primary human lung epithelial cell differentiation. PLoS Genet. 2013 Jun; 9(6):e1003513. Marconett CN, Zhou B, Rieger ME, Selamat SA, Dubourd M, Fang X, Lynch SK, Stueve TR, Siegmund KD, Berman BP, Borok Z, Laird-Offringa IA. PMID: 23818859.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    43. Low-level processing of Illumina Infinium DNA Methylation BeadArrays. Nucleic Acids Res. 2013 Apr; 41(7):e90. Triche TJ, Weisenberger DJ, Van Den Berg D, Laird PW, Siegmund KD. PMID: 23476028.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansCells
    44. Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23. Hum Mol Genet. 2013 Jul 01; 22(13):2748-53. Schumacher FR, Wang Z, Skotheim RI, Koster R, Chung CC, Hildebrandt MA, Kratz CP, Bakken AC, Bishop DT, Cook MB, Erickson RL, Fosså SD, Greene MH, Jacobs KB, Kanetsky PA, Kolonel LN, Loud JT, Korde LA, Le Marchand L, Lewinger JP, Lothe RA, Pike MC, Rahman N, Rubertone MV, Schwartz SM, Siegmund KD, Skinner EC, Turnbull C, Van Den Berg DJ, Wu X, Yeager M, Nathanson KL, Chanock SJ, Cortessis VK, McGlynn KA. PMID: 23462292.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    45. G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of glucocorticoid receptor target genes. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19673-8. Bittencourt D, Wu DY, Jeong KW, Gerke DS, Herviou L, Ianculescu I, Chodankar R, Siegmund KD, Stallcup MR. PMID: 23151507.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    46. Bis-SNP: combined DNA methylation and SNP calling for Bisulfite-seq data. Genome Biol. 2012 Jul 11; 13(7):R61. Liu Y, Siegmund KD, Laird PW, Berman BP. PMID: 22784381.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    47. Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships. Hum Genet. 2012 Oct; 131(10):1565-89. Cortessis VK, Thomas DC, Levine AJ, Breton CV, Mack TM, Siegmund KD, Haile RW, Laird PW. PMID: 22740325.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsPHPublic Health
    48. Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression. Genome Res. 2012 Jul; 22(7):1197-211. Selamat SA, Chung BS, Girard L, Zhang W, Zhang Y, Campan M, Siegmund KD, Koss MN, Hagen JA, Lam WL, Lam S, Gazdar AF, Laird-Offringa IA. PMID: 22613842.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansCells
    49. Particulate matter, DNA methylation in nitric oxide synthase, and childhood respiratory disease. Environ Health Perspect. 2012 Sep; 120(9):1320-6. Breton CV, Salam MT, Wang X, Byun HM, Siegmund KD, Gilliland FD. PMID: 22591701.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCellsPHPublic Health
    50. Shorter androgen receptor CAG repeat lengths associated with cryptorchidism risk among Hispanic white boys. J Clin Endocrinol Metab. 2012 Mar; 97(3):E393-9. Davis-Dao C, Koh CJ, Hardy BE, Chang A, Kim SS, De Filippo R, Hwang A, Pike MC, Carroll JD, Coetzee GA, Vandenberg D, Siegmund K, Cortessis VK. PMID: 22188741.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    51. Selective roles for cAMP response element-binding protein binding protein and p300 protein as coregulators for androgen-regulated gene expression in advanced prostate cancer cells. J Biol Chem. 2012 Feb 03; 287(6):4000-13. Ianculescu I, Wu DY, Siegmund KD, Stallcup MR. PMID: 22174411.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    52. Genome-scale screen for DNA methylation-based detection markers for ovarian cancer. PLoS One. 2011; 6(12):e28141. Campan M, Moffitt M, Houshdaran S, Shen H, Widschwendter M, Daxenbichler G, Long T, Marth C, Laird-Offringa IA, Press MF, Dubeau L, Siegmund KD, Wu AH, Groshen S, Chandavarkar U, Roman LD, Berchuck A, Pearce CL, Laird PW. PMID: 22163280.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    53. Repeated assessment by high-throughput assay demonstrates that sperm DNA methylation levels are highly reproducible. Fertil Steril. 2011 Dec; 96(6):1325-30. Cortessis VK, Siegmund K, Houshdaran S, Laird PW, Sokol RZ. PMID: 22035967.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    54. Epigenetic subgroups of esophageal and gastric adenocarcinoma with differential GATA5 DNA methylation associated with clinical and lifestyle factors. PLoS One. 2011; 6(10):e25985. Wang X, Kang GH, Campan M, Weisenberger DJ, Long TI, Cozen W, Bernstein L, Wu AH, Siegmund KD, Shibata D, Laird PW. PMID: 22028801.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    55. Carcinogen metabolism genes, red meat and poultry intake, and colorectal cancer risk. Int J Cancer. 2012 Apr 15; 130(8):1898-907. Wang J, Joshi AD, Corral R, Siegmund KD, Marchand LL, Martinez ME, Haile RW, Ahnen DJ, Sandler RS, Lance P, Stern MC. PMID: 21618522.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    56. Soy food supplementation, dietary fat reduction and peripheral blood gene expression in postmenopausal women--a randomized, controlled trial. Mol Nutr Food Res. 2011 Sep; 55 Suppl 2:S264-77. Wang J, Siegmund K, Tseng CC, Lee AS, Wu AH. PMID: 21823222.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    57. Modeling measurement error in tumor characterization studies. BMC Bioinformatics. 2011 Jul 13; 12:284. Rakovski C, Weisenberger DJ, Marjoram P, Laird PW, Siegmund KD. PMID: 21752297.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    58. High DNA methylation pattern intratumoral diversity implies weak selection in many human colorectal cancers. PLoS One. 2011; 6(6):e21657. Siegmund KD, Marjoram P, Tavaré S, Shibata D. PMID: 21738754.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    59. DNA methylation changes in atypical adenomatous hyperplasia, adenocarcinoma in situ, and lung adenocarcinoma. PLoS One. 2011; 6(6):e21443. Selamat SA, Galler JS, Joshi AD, Fyfe MN, Campan M, Siegmund KD, Kerr KM, Laird-Offringa IA. PMID: 21731750.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    60. Human and great ape red blood cells differ in plasmalogen levels and composition. Lipids Health Dis. 2011 Jun 17; 10:101. Moser AB, Steinberg SJ, Watkins PA, Moser HW, Ramaswamy K, Siegmund KD, Lee DR, Ely JJ, Ryder OA, Hacia JG. PMID: 21679470.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    61. Heterogenous effect of androgen receptor CAG tract length on testicular germ cell tumor risk: shorter repeats associated with seminoma but not other histologic types. Carcinogenesis. 2011 Aug; 32(8):1238-43. Davis-Dao CA, Siegmund KD, Vandenberg DJ, Skinner EC, Coetzee GA, Thomas DC, Pike MC, Cortessis VK. PMID: 21642359.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    62. Statistical approaches for the analysis of DNA methylation microarray data. Hum Genet. 2011 Jun; 129(6):585-95. Siegmund KD. PMID: 21519831.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    63. DNA methylation in the arginase-nitric oxide synthase pathway is associated with exhaled nitric oxide in children with asthma. Am J Respir Crit Care Med. 2011 Jul 15; 184(2):191-7. Breton CV, Byun HM, Wang X, Salam MT, Siegmund K, Gilliland FD. PMID: 21512169.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    64. Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat. Cancer Epidemiol Biomarkers Prev. 2010 Dec; 19(12):3167-73. Brevik A, Joshi AD, Corral R, Onland-Moret NC, Siegmund KD, Le Marchand L, Baron JA, Martinez ME, Haile RW, Ahnen DJ, Sandler RS, Lance P, Stern MC. PMID: 21037106.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    65. Identification of differences in human and great ape phytanic acid metabolism that could influence gene expression profiles and physiological functions. BMC Physiol. 2010 Oct 08; 10:19. Watkins PA, Moser AB, Toomer CB, Steinberg SJ, Moser HW, Karaman MW, Ramaswamy K, Siegmund KD, Lee DR, Ely JJ, Ryder OA, Hacia JG. PMID: 20932325.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    66. Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue. Cancer Res. 2010 Oct 15; 70(20):8169-78. Wolff EM, Chihara Y, Pan F, Weisenberger DJ, Siegmund KD, Sugano K, Kawashima K, Laird PW, Jones PA, Liang G. PMID: 20841482.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    67. The PREMM(1,2,6) model predicts risk of MLH1, MSH2, and MSH6 germline mutations based on cancer history. Gastroenterology. 2011 Jan; 140(1):73-81. Kastrinos F, Steyerberg EW, Mercado R, Balmaña J, Holter S, Gallinger S, Siegmund KD, Church JM, Jenkins MA, Lindor NM, Thibodeau SN, Burbidge LA, Wenstrup RJ, Syngal S. PMID: 20727894.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    68. Using DNA methylation patterns to infer tumor ancestry. PLoS One. 2010 Aug 09; 5(8):e12002. Hong YJ, Marjoram P, Shibata D, Siegmund KD. PMID: 20711251.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    69. Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer. PLoS Genet. 2010 Apr 22; 6(4):e1000917. Wolff EM, Byun HM, Han HF, Sharma S, Nichols PW, Siegmund KD, Yang AS, Jones PA, Liang G. PMID: 20421991.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansCells
    70. Identification and functional relevance of de novo DNA methylation in cancerous B-cell populations. J Cell Biochem. 2010 Mar 01; 109(4):818-27. Wang XM, Greiner TC, Bibikova M, Pike BL, Siegmund KD, Sinha UK, Müschen M, Jaeger EB, Weisenburger DD, Chan WC, Shibata D, Fan JB, Hacia JG. PMID: 20069569.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    71. Hormone therapy, DNA methylation and colon cancer. Carcinogenesis. 2010 Jun; 31(6):1060-7. Wu AH, Siegmund KD, Long TI, Cozen W, Wan P, Tseng CC, Shibata D, Laird PW. PMID: 20064828.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    72. Copy number variation in the Framingham Heart Study. BMC Proc. 2009 Dec 15; 3 Suppl 7:S133. Shtir C, Pique-Regi R, Siegmund K, Morrison J, Schumacher F, Marjoram P. PMID: 20018000.
      View in: PubMed   Mentions:
    73. Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns. Hum Mol Genet. 2009 Dec 15; 18(24):4808-17. Byun HM, Siegmund KD, Pan F, Weisenberger DJ, Kanel G, Laird PW, Yang AS. PMID: 19776032.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansCells
    74. Associations between smoking, alcohol consumption, and colorectal cancer, overall and by tumor microsatellite instability status. Cancer Epidemiol Biomarkers Prev. 2009 Oct; 18(10):2745-50. Poynter JN, Haile RW, Siegmund KD, Campbell PT, Figueiredo JC, Limburg P, Young J, Le Marchand L, Potter JD, Cotterchio M, Casey G, Hopper JL, Jenkins MA, Thibodeau SN, Newcomb PA, Baron JA. PMID: 19755657.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    75. Many colorectal cancers are "flat" clonal expansions. Cell Cycle. 2009 Jul 15; 8(14):2187-93. Siegmund KD, Marjoram P, Tavaré S, Shibata D. PMID: 19556889.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    76. Development and evaluation of new mask protocols for gene expression profiling in humans and chimpanzees. BMC Bioinformatics. 2009 Mar 05; 10:77. Toleno DM, Renaud G, Wolfsberg TG, Islam M, Wildman DE, Siegmund KD, Hacia JG. PMID: 19265541.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    77. Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers. Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4828-33. Siegmund KD, Marjoram P, Woo YJ, Tavaré S, Shibata D. PMID: 19261858.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    78. The association of tumor microsatellite instability phenotype with family history of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2009 Mar; 18(3):967-75. Bapat B, Lindor NM, Baron J, Siegmund K, Li L, Zheng Y, Haile R, Gallinger S, Jass JR, Young JP, Cotterchio M, Jenkins M, Grove J, Casey G, Thibodeau SN, Bishop DT, Hopper JL, Ahnen D, Newcomb PA, Le Marchand L, Potter JD, Seminara D. PMID: 19258475.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    79. Older individuals appear to acquire mitotically older colorectal cancers. J Pathol. 2009 Mar; 217(4):483-8. Woo YJ, Siegmund KD, Tavaré S, Shibata D. PMID: 19165870.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    80. Red meat and poultry intake, polymorphisms in the nucleotide excision repair and mismatch repair pathways and colorectal cancer risk. Carcinogenesis. 2009 Mar; 30(3):472-9. Joshi AD, Corral R, Siegmund KD, Haile RW, Le Marchand L, Martínez ME, Ahnen DJ, Sandler RS, Lance P, Stern MC. PMID: 19029193.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    81. mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograft. BMC Genomics. 2008 Nov 03; 9:521. Magda D, Lecane P, Prescott J, Thiemann P, Ma X, Dranchak PK, Toleno DM, Ramaswamy K, Siegmund KD, Hacia JG. PMID: 18980691.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    82. Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening. Cancer Epidemiol Biomarkers Prev. 2008 Nov; 17(11):3208-15. Poynter JN, Siegmund KD, Weisenberger DJ, Long TI, Thibodeau SN, Lindor N, Young J, Jenkins MA, Hopper JL, Baron JA, Buchanan D, Casey G, Levine AJ, Le Marchand L, Gallinger S, Bapat B, Potter JD, Newcomb PA, Haile RW, Laird PW. PMID: 18990764.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    83. Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer. Mol Cancer. 2008 Jul 10; 7:62. Anglim PP, Galler JS, Koss MN, Hagen JA, Turla S, Campan M, Weisenberger DJ, Laird PW, Siegmund KD, Laird-Offringa IA. PMID: 18616821.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    84. Modeling DNA methylation in a population of cancer cells. Stat Appl Genet Mol Biol. 2008; 7(1):Article 18. Siegmund KD, Marjoram P, Shibata D. PMID: 18597664.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    85. Inferring relative numbers of human leucocyte genome replications. Br J Haematol. 2008 Jun; 141(6):862-71. Chu M, Siegmund KD, Hao QL, Crooks GM, Tavaré S, Shibata D. PMID: 18410448.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    86. DNA methylation profiles in diffuse large B-cell lymphoma and their relationship to gene expression status. Leukemia. 2008 May; 22(5):1035-43. Pike BL, Greiner TC, Wang X, Weisenburger DD, Hsu YH, Renaud G, Wolfsberg TG, Kim M, Weisenberger DJ, Siegmund KD, Ye W, Groshen S, Mehrian-Shai R, Delabie J, Chan WC, Laird PW, Hacia JG. PMID: 18288132.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    87. Widespread epigenetic abnormalities suggest a broad DNA methylation erasure defect in abnormal human sperm. PLoS One. 2007 Dec 12; 2(12):e1289. Houshdaran S, Cortessis VK, Siegmund K, Yang A, Laird PW, Sokol RZ. PMID: 18074014.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    88. Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family Registry. Cancer Res. 2007 Dec 01; 67(23):11128-32. Poynter JN, Figueiredo JC, Conti DV, Kennedy K, Gallinger S, Siegmund KD, Casey G, Thibodeau SN, Jenkins MA, Hopper JL, Byrnes GB, Baron JA, Goode EL, Tiirikainen M, Lindor N, Grove J, Newcomb P, Jass J, Young J, Potter JD, Haile RW, Duggan DJ, Le Marchand L. PMID: 18056436.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    89. DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study. Cancer Epidemiol Biomarkers Prev. 2007 Nov; 16(11):2363-72. Stern MC, Conti DV, Siegmund KD, Corral R, Yuan JM, Koh WP, Yu MC. PMID: 18006925.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    90. Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma. Mol Cancer. 2007 Oct 29; 6:70. Tsou JA, Galler JS, Siegmund KD, Laird PW, Turla S, Cozen W, Hagen JA, Koss MN, Laird-Offringa IA. PMID: 17967182.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    91. Morbid obesity adversely impacts pelvic floor function in females seeking attention for weight loss surgery. Dis Colon Rectum. 2007 Dec; 50(12):2096-103. Wasserberg N, Haney M, Petrone P, Ritter M, Emami C, Rosca J, Siegmund K, Kaufman HS. PMID: 17899277.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    92. DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS One. 2007 Sep 19; 2(9):e895. Siegmund KD, Connor CM, Campan M, Long TI, Weisenberger DJ, Biniszkiewicz D, Jaenisch R, Laird PW, Akbarian S. PMID: 17878930.
      View in: PubMed   Mentions: 160     Fields:    Translation:HumansCells
    93. Lack of increases in methylation at three CpG-rich genomic loci in non-mitotic adult tissues during aging. BMC Med Genet. 2007 Jul 31; 8:50. Chu MW, Siegmund KD, Eckstam CL, Kim JY, Yang AS, Kanel GC, Tavaré S, Shibata D. PMID: 17672908.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    94. DNA methylation profile of 28 potential marker loci in malignant mesothelioma. Lung Cancer. 2007 Nov; 58(2):220-30. Tsou JA, Galler JS, Wali A, Ye W, Siegmund KD, Groshen S, Laird PW, Turla S, Koss MN, Pass HI, Laird-Offringa IA. PMID: 17659810.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    95. Statistical methods for evaluating DNA methylation as a marker for early detection or prognosis. Dis Markers. 2007; 23(1-2):113-20. Alonzo TA, Siegmund KD. PMID: 17325431.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    96. XRCC1, XRCC3, and XPD polymorphisms as modifiers of the effect of smoking and alcohol on colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev. 2006 Dec; 15(12):2384-90. Stern MC, Siegmund KD, Conti DV, Corral R, Haile RW. PMID: 17164360.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    97. Cluster analysis for DNA methylation profiles having a detection threshold. BMC Bioinformatics. 2006 Jul 26; 7:361. Marjoram P, Chang J, Laird PW, Siegmund KD. PMID: 16872497.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    98. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet. 2006 Jul; 38(7):787-93. Weisenberger DJ, Siegmund KD, Campan M, Young J, Long TI, Faasse MA, Kang GH, Widschwendter M, Weener D, Buchanan D, Koh H, Simms L, Barker M, Leggett B, Levine J, Kim M, French AJ, Thibodeau SN, Jass J, Haile R, Laird PW. PMID: 16804544.
      View in: PubMed   Mentions: 680     Fields:    Translation:HumansCells
    99. Modeling exposures for DNA methylation profiles. Cancer Epidemiol Biomarkers Prev. 2006 Mar; 15(3):567-72. Siegmund KD, Levine AJ, Chang J, Laird PW. PMID: 16537717.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    100. Identifying susceptibility genes by using joint tests of association and linkage and accounting for epistasis. BMC Genet. 2005 Dec 30; 6 Suppl 1:S147. Millstein J, Siegmund KD, Conti DV, Gauderman WJ. PMID: 16451607.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    101. Testing association and linkage using affected-sib-parent study designs. Genet Epidemiol. 2005 Nov; 29(3):225-33. Millstein J, Siegmund KD, Conti DV, Gauderman WJ. PMID: 16121357.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    102. Prognostic relevance of methylation markers in patients with non-muscle invasive bladder carcinoma. Eur J Cancer. 2005 Nov; 41(17):2769-78. Friedrich MG, Chandrasoma S, Siegmund KD, Weisenberger DJ, Cheng JC, Toma MI, Huland H, Jones PA, Liang G. PMID: 16242928.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    103. Age-related human small intestine methylation: evidence for stem cell niches. BMC Med. 2005 Jun 23; 3:10. Kim JY, Siegmund KD, Tavaré S, Shibata D. PMID: 15975143.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    104. Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X. JAMA. 2005 Apr 27; 293(16):1979-85. Lindor NM, Rabe K, Petersen GM, Haile R, Casey G, Baron J, Gallinger S, Bapat B, Aronson M, Hopper J, Jass J, LeMarchand L, Grove J, Potter J, Newcomb P, Terdiman JP, Conrad P, Moslein G, Goldberg R, Ziogas A, Anton-Culver H, de Andrade M, Siegmund K, Thibodeau SN, Boardman LA, Seminara D. PMID: 15855431.
      View in: PubMed   Mentions: 167     Fields:    Translation:HumansCellsPHPublic Health
    105. XRCC1 and XRCC3 polymorphisms and their role as effect modifiers of unsaturated fatty acids and antioxidant intake on colorectal adenomas risk. Cancer Epidemiol Biomarkers Prev. 2005 Mar; 14(3):609-15. Stern MC, Siegmund KD, Corral R, Haile RW. PMID: 15767338.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    106. Distinct DNA methylation profiles in malignant mesothelioma, lung adenocarcinoma, and non-tumor lung. Lung Cancer. 2005 Feb; 47(2):193-204. Tsou JA, Shen LY, Siegmund KD, Long TI, Laird PW, Seneviratne CK, Koss MN, Pass HI, Hagen JA, Laird-Offringa IA. PMID: 15639718.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    107. Detection of methylated apoptosis-associated genes in urine sediments of bladder cancer patients. Clin Cancer Res. 2004 Nov 15; 10(22):7457-65. Friedrich MG, Weisenberger DJ, Cheng JC, Chandrasoma S, Siegmund KD, Gonzalgo ML, Toma MI, Huland H, Yoo C, Tsai YC, Nichols PW, Bochner BH, Jones PA, Liang G. PMID: 15569975.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    108. Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen. Cancer Res. 2004 Jun 01; 64(11):3807-13. Widschwendter M, Siegmund KD, Müller HM, Fiegl H, Marth C, Müller-Holzner E, Jones PA, Laird PW. PMID: 15172987.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansCells
    109. A comparison of cluster analysis methods using DNA methylation data. Bioinformatics. 2004 Aug 12; 20(12):1896-904. Siegmund KD, Laird PW, Laird-Offringa IA. PMID: 15044245.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    110. A case-control study of cyclin D1 CCND1 870A-->G polymorphism and bladder cancer. Carcinogenesis. 2003 Oct; 24(10):1645-50. Cortessis VK, Siegmund K, Xue S, Ross RK, Yu MC. PMID: 12896908.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    111. Diet, cancer and aging in DNA mismatch repair deficient mice. Carcinogenesis. 2002 Nov; 23(11):1807-10. Tsao JL, Dudley S, Kwok B, Nickel AE, Laird PW, Siegmund KD, Liskay RM, Shibata D. PMID: 12419828.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    112. Analysis of complex methylation data. Methods. 2002 Jun; 27(2):170-8. Siegmund KD, Laird PW. PMID: 12095277.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    113. Ascertainment bias in family-based case-control studies. Am J Epidemiol. 2002 May 01; 155(9):875-80. Siegmund KD, Langholz B. PMID: 11978593.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    114. Hierarchical clustering of lung cancer cell lines using DNA methylation markers. Cancer Epidemiol Biomarkers Prev. 2002 Mar; 11(3):291-7. Virmani AK, Tsou JA, Siegmund KD, Shen LY, Long TI, Laird PW, Gazdar AF, Laird-Offringa IA. PMID: 11895880.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    115. Stratified case sampling and the use of family controls. Genet Epidemiol. 2001 Apr; 20(3):316-27. Siegmund KD, Langholz B. PMID: 11255241.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    116. A case-control study of microsomal epoxide hydrolase, smoking, meat consumption, glutathione S-transferase M3, and risk of colorectal adenomas. Cancer Res. 2001 Mar 15; 61(6):2381-5. Cortessis V, Siegmund K, Chen Q, Zhou N, Diep A, Frankl H, Lee E, Zhu QS, Haile R, Levy D. PMID: 11289100.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    117. Association tests in nuclear families. Hum Hered. 2001; 52(2):66-76. Siegmund KD, Gauderman WJ. PMID: 11474207.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    118. Gene-environment interaction and affected sib pair linkage analysis. Hum Hered. 2001; 52(1):34-46. Gauderman WJ, Siegmund KD. PMID: 11359066.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    119. Combined linkage and association analysis in pedigrees. Genet Epidemiol. 2001; 21 Suppl 1:S358-63. Siegmund KD, Vora H, Gauderman WJ. PMID: 11793698.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    120. Should we consider gene x environment interaction in the hunt for quantitative trait loci? Genet Epidemiol. 2001; 21 Suppl 1:S831-6. Gauderman WJ, Morrison JL, Siegmund KD. PMID: 11793788.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    121. Hostility, social support, and carotid artery atherosclerosis in the National Heart, Lung, and Blood Institute Family Heart Study. Am J Cardiol. 2000 Nov 15; 86(10):1086-9. Knox SS, Adelman A, Ellison RC, Arnett DK, Siegmund K, Weidner G, Province MA. PMID: 11074204.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    122. The methylenetetrahydrofolate reductase 677C-->T polymorphism and distal colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev. 2000 Jul; 9(7):657-63. Levine AJ, Siegmund KD, Ervin CM, Diep A, Lee ER, Frankl HD, Haile RW. PMID: 10919734.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    123. Testing linkage disequilibrium in sibships. Am J Hum Genet. 2000 Jul; 67(1):244-8. Siegmund KD, Langholz B, Kraft P, Thomas DC. PMID: 10831398.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    124. Linkage analysis for diseases with variable age of onset. Hum Hered. 2000 May-Jun; 50(3):205-10. Siegmund KD, Todorov AA. PMID: 10686502.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    125. A frailty approach for modelling diseases with variable age of onset in families: the NHLBI Family Heart Study. Stat Med. 1999 Jun 30; 18(12):1517-28. Siegmund KD, Todorov AA, Province MA. PMID: 10398289.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    126. Multistage sampling for disease family registries. J Natl Cancer Inst Monogr. 1999; (26):43-8. Siegmund KD, Whittemore AS, Thomas DC. PMID: 10854485.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    127. A generalized estimating equations approach to linkage analysis in sibships in relation to multiple markers and exposure factors. Genet Epidemiol. 1999; 17 Suppl 1:S737-42. Thomas DC, Qian D, Gauderman WJ, Siegmund K, Morrison JL. PMID: 10597523.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    128. A joint test of linkage and gene x environment interaction, with affected sib pairs. Genet Epidemiol. 1999; 17 Suppl 1:S563-8. Gauderman WJ, Morrison JL, Siegmund KD, Thomas DC. PMID: 10597493.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    129. Study-design issues in the development of the University of Southern California Consortium's Colorectal Cancer Family Registry. J Natl Cancer Inst Monogr. 1999; (26):89-93. Haile RW, Siegmund KD, Gauderman WJ, Thomas DC. PMID: 10854491.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    130. Association tests using unaffected-sibling versus pseudo-sibling controls. Genet Epidemiol. 1999; 17 Suppl 1:S731-6. Siegmund KD, Gauderman WJ, Thomas DC. PMID: 10597522.
      View in: PubMed   Mentions:    Fields:    
    131. Lipoprotein(a) interactions with lipid and non-lipid risk factors in patients with early onset coronary artery disease: results from the NHLBI Family Heart Study. Atherosclerosis. 1998 Dec; 141(2):333-45. Hopkins PN, Hunt SC, Schreiner PJ, Eckfeldt JH, Borecki IB, Ellison CR, Williams RR, Siegmund KD. PMID: 9862182.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    132. Modeling disease incidence rates in families. Epidemiology. 1998 Sep; 9(5):557-62. Siegmund KD, Province MA, Higgins M, Williams RR, Keller J, Todorov AA. PMID: 9730037.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    133. Modeling hazard functions in families. Genet Epidemiol. 1998; 15(2):147-71. Siegmund K, McKnight B. PMID: 9554553.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    134. A study of reproductive function in patients with seminoma treated with radiotherapy and orchidectomy: (SWOG-8711). Southwest Oncology Group. Int J Radiat Oncol Biol Phys. 1997 Apr 01; 38(1):83-94. Gordon W, Siegmund K, Stanisic TH, McKnight B, Harris IT, Carroll PR, Paradelo JC, Meyers FJ, Chapman RA, Meyskens FL. PMID: 9212008.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    135. Probabilities of identity-by-descent patterns in sibships when the parents are not genotyped. Genet Epidemiol. 1997; 14(6):909-13. Todorov AA, Siegmund KD, Gu C, Borecki IB, Elston RC. PMID: 9433599.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    136. The role of smoothing techniques in the interpretation of results from genomic scans using sib-pair data. Genet Epidemiol. 1997; 14(6):1047-52. Siegmund KD, Todorov AA, Rao DC, Borecki IB. PMID: 9433622.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    137. Analysis of quantitative risk factors for a common oligogenic disease. Genet Epidemiol. 1995; 12(6):759-64. Goddard KA, Jarvik GP, Graham J, McNeney B, Hsu L, Siegmund K, Grosser S, Olson J, Wijsman EM. PMID: 8788005.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    Kimberly's Networks
    Concepts (509)
    Derived automatically from this person's publications.
    _
    Co-Authors (68)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _