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The interplay of DNA damage and repair, gene expression, and mutagenesis in mammalian cells during oxidative stress. Carcinogenesis. 2024 Nov 22; 45(11):868-879.
Besaratinia A, Caliri AW, Tommasi S. PMID: 39023127; PMCID: PMC11584291.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Epigenomic Dysregulation in Youth Vapers: Implications for Disease Risk Assessment. Am J Respir Cell Mol Biol. 2024 Aug 12.
Tommasi S, Brocchieri L, Tornaletti S, Besaratinia A. PMID: 39133188.
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PubMed Mentions: Fields:
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The Untapped Biomarker Potential of MicroRNAs for Health Risk-Benefit Analysis of Vaping vs. Smoking. Cells. 2024 Aug 10; 13(16).
Besaratinia A, Tommasi S. PMID: 39195220; PMCID: PMC11352591.
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PubMed Mentions: Fields:
Translation:
Humans
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Exploring the Utility of Long Non-Coding RNAs for Assessing the Health Consequences of Vaping. Int J Mol Sci. 2024 Aug 05; 25(15).
Besaratinia A, Blumenfeld H, Tommasi S. PMID: 39126120; PMCID: PMC11313266.
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PubMed Mentions: Fields:
Translation:
Humans
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Vaping Dose, Device Type, and E-Liquid Flavor are Determinants of DNA Damage in Electronic Cigarette Users. Nicotine Tob Res. 2023 05 22; 25(6):1145-1154.
Tommasi S, Blumenfeld H, Besaratinia A. PMID: 36780924; PMCID: PMC10202635.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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DNA Hydroxymethylation in Smoking-Associated Cancers. Int J Mol Sci. 2022 Feb 28; 23(5).
Besaratinia A, Caceres A, Tommasi S. PMID: 35269796; PMCID: PMC8910185.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Secondhand smoke affects reproductive functions by altering the mouse testis transcriptome, and leads to select intron retention in Pde1a. Environ Int. 2022 03; 161:107086.
Tommasi S, Kitapci TH, Blumenfeld H, Besaratinia A. PMID: 35063792; PMCID: PMC8891074.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCellsPHPublic Health
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A novel role for vaping in mitochondrial gene dysregulation and inflammation fundamental to disease development. Sci Rep. 2021 11 23; 11(1):22773.
Tommasi S, Pabustan N, Li M, Chen Y, Siegmund KD, Besaratinia A. PMID: 34815430; PMCID: PMC8611078.
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PubMed Mentions:
13 Fields:
Translation:
Humans
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Hydroxychloroquine induces oxidative DNA damage and mutation in mammalian cells. DNA Repair (Amst). 2021 10; 106:103180.
Besaratinia A, Caliri AW, Tommasi S. PMID: 34298488; PMCID: PMC8435022.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCellsPHPublic Health
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The consequential impact of JUUL on youth vaping and the landscape of tobacco products: The state of play in the COVID-19 era. Prev Med Rep. 2021 Jun; 22:101374.
Besaratinia A, Tommasi S. PMID: 34168950; PMCID: PMC8207461.
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PubMed Mentions:
15
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Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer. Mutat Res Rev Mutat Res. 2021 Jan-Jun; 787:108365.
Caliri AW, Tommasi S, Besaratinia A. PMID: 34083039; PMCID: PMC8287787.
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PubMed Mentions:
165 Fields:
Translation:
HumansAnimals
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Spontaneous and photosensitization-induced mutations in primary mouse cells transitioning through senescence and immortalization. J Biol Chem. 2020 07 17; 295(29):9974-9985.
Caliri AW, Tommasi S, Bates SE, Besaratinia A. PMID: 32487750; PMCID: PMC7380187.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Vaping epidemic: challenges and opportunities. Cancer Causes Control. 2020 Jul; 31(7):663-667.
Besaratinia A, Tommasi S. PMID: 32363571; PMCID: PMC7274878.
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PubMed Mentions:
23 Fields:
Translation:
HumansPHPublic Health
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Secondhand Smoke Induces Liver Steatosis through Deregulation of Genes Involved in Hepatic Lipid Metabolism. Int J Mol Sci. 2020 Feb 14; 21(4).
Tommasi S, Yoon JI, Besaratinia A. PMID: 32075112; PMCID: PMC7072934.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCellsPHPublic Health
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Hypomethylation of LINE-1 repeat elements and global loss of DNA hydroxymethylation in vapers and smokers. Epigenetics. 2020 08; 15(8):816-829.
Caliri AW, Caceres A, Tommasi S, Besaratinia A. PMID: 31996072; PMCID: PMC7518689.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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Vaping: A growing global health concern. EClinicalMedicine. 2019 Dec; 17:100208.
Besaratinia A, Tommasi S. PMID: 31891141; PMCID: PMC6933142.
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PubMed Mentions:
34
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DNA Hydroxymethylation at the Interface of the Environment and Nonalcoholic Fatty Liver Disease. Int J Environ Res Public Health. 2019 08 05; 16(15).
Tommasi S, Besaratinia A. PMID: 31387232; PMCID: PMC6695744.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Deregulation of Biologically Significant Genes and Associated Molecular Pathways in the Oral Epithelium of Electronic Cigarette Users. Int J Mol Sci. 2019 Feb 10; 20(3).
Tommasi S, Caliri AW, Caceres A, Moreno DE, Li M, Chen Y, Siegmund KD, Besaratinia A. PMID: 30744164; PMCID: PMC6386888.
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PubMed Mentions:
42 Fields:
Translation:
HumansCells
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The Lambda Select cII Mutation Detection System. J Vis Exp. 2018 04 26; (134).
Besaratinia A, Tommasi S. PMID: 29757290; PMCID: PMC6100978.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Mutation Analysis in Cultured Cells of Transgenic Rodents. Int J Mol Sci. 2018 Jan 16; 19(1).
Besaratinia A, Zheng A, Bates SE, Tommasi S. PMID: 29337872; PMCID: PMC5796208.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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A Versatile Assay for Detection of Aberrant DNA Methylation in Bladder Cancer. Methods Mol Biol. 2018; 1655:29-41.
Tommasi S, Besaratinia A. PMID: 28889375; PMCID: PMC6340640.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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An opportune and unique research to evaluate the public health impact of electronic cigarettes. Cancer Causes Control. 2017 Oct; 28(10):1167-1171.
Besaratinia A, Tommasi S. PMID: 28861656; PMCID: PMC5693655.
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PubMed Mentions:
22 Fields:
Translation:
Humans
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Limited mutagenicity of electronic cigarettes in mouse or human cells in vitro. Lung Cancer. 2017 10; 112:41-46.
Tommasi S, Bates SE, Behar RZ, Talbot P, Besaratinia A. PMID: 29191599; PMCID: PMC5726426.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Expression of epigenetic modifiers is not significantly altered by exposure to secondhand smoke. Lung Cancer. 2015 Dec; 90(3):598-603.
Tommasi S, Zheng A, Besaratinia A. PMID: 26525280; PMCID: PMC7849627.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCellsPHPublic Health
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The lingering question of menthol in cigarettes. Cancer Causes Control. 2015 Feb; 26(2):165-169.
Besaratinia A, Tommasi S. PMID: 25416451.
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PubMed Mentions:
5 Fields:
Translation:
HumansPHPublic Health
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Exposure of mice to secondhand smoke elicits both transient and long-lasting transcriptional changes in cancer-related functional networks. Int J Cancer. 2015 May 15; 136(10):2253-63.
Tommasi S, Zheng A, Besaratinia A. PMID: 25346222.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCellsPHPublic Health
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RASSF6 exhibits promoter hypermethylation in metastatic melanoma and inhibits invasion in melanoma cells. Epigenetics. 2014 Nov; 9(11):1496-503.
Mezzanotte JJ, Hill V, Schmidt ML, Shinawi T, Tommasi S, Krex D, Schackert G, Pfeifer GP, Latif F, Clark GJ. PMID: 25482183; PMCID: PMC4623409.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Electronic cigarettes: the road ahead. Prev Med. 2014 Sep; 66:65-7.
Besaratinia A, Tommasi S. PMID: 24952095.
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PubMed Mentions:
16 Fields:
Translation:
Humans
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Epigenetics of human melanoma: promises and challenges. J Mol Cell Biol. 2014 Oct; 6(5):356-67.
Besaratinia A, Tommasi S. PMID: 24895357.
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PubMed Mentions:
22 Fields:
Translation:
HumansCells
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Epigenetic targeting of the Nanog pathway and signaling networks during chemical carcinogenesis. Carcinogenesis. 2014 Aug; 35(8):1726-36.
Tommasi S, Zheng A, Yoon JI, Besaratinia A. PMID: 24480805.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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View in:
PubMed Mentions:
28 Fields:
Translation:
HumansCells
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Genotoxicity of tobacco smoke-derived aromatic amines and bladder cancer: current state of knowledge and future research directions. FASEB J. 2013 Jun; 27(6):2090-100.
Besaratinia A, Tommasi S. PMID: 23449930.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimals
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Mammalian cells acquire epigenetic hallmarks of human cancer during immortalization. Nucleic Acids Res. 2013 Jan 07; 41(1):182-95.
Tommasi S, Zheng A, Weninger A, Bates SE, Li XA, Wu X, Hollstein M, Besaratinia A. PMID: 23143272; PMCID: PMC3592471.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Whole DNA methylome profiling in mice exposed to secondhand smoke. Epigenetics. 2012 Nov; 7(11):1302-14.
Tommasi S, Zheng A, Yoon JI, Li AX, Wu X, Besaratinia A. PMID: 23051858; PMCID: PMC3499331.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCellsPHPublic Health
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A high-throughput next-generation sequencing-based method for detecting the mutational fingerprint of carcinogens. Nucleic Acids Res. 2012 Aug; 40(15):e116.
Besaratinia A, Li H, Yoon JI, Zheng A, Gao H, Tommasi S. PMID: 22735701; PMCID: PMC3424585.
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PubMed Mentions:
17 Fields:
Translation:
Animals
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New experimental data linking secondhand smoke exposure to lung cancer in nonsmokers. FASEB J. 2012 May; 26(5):1845-54.
Kim SI, Yoon JI, Tommasi S, Besaratinia A. PMID: 22318968.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsPHPublic Health
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Organ specificity of the bladder carcinogen 4-aminobiphenyl in inducing DNA damage and mutation in mice. Cancer Prev Res (Phila). 2012 Feb; 5(2):299-308.
Yoon JI, Kim SI, Tommasi S, Besaratinia A. PMID: 22086680.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Investigating the epigenetic effects of a prototype smoke-derived carcinogen in human cells. PLoS One. 2010 May 12; 5(5):e10594.
Tommasi S, Kim SI, Zhong X, Wu X, Pfeifer GP, Besaratinia A. PMID: 20485678; PMCID: PMC2868871.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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RASSF proteins. Curr Biol. 2010 Apr 27; 20(8):R344-5.
Pfeifer GP, Dammann R, Tommasi S. PMID: 21749948.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Identification of 5 novel genes methylated in breast and other epithelial cancers. Mol Cancer. 2010 Mar 05; 9:51.
Hill VK, Hesson LB, Dansranjavin T, Dallol A, Bieche I, Vacher S, Tommasi S, Dobbins T, Gentle D, Euhus D, Lewis C, Dammann R, Ward RL, Minna J, Maher ER, Pfeifer GP, Latif F. PMID: 20205715; PMCID: PMC2841122.
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PubMed Mentions:
44 Fields:
Translation:
HumansCells
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Tumor suppressor Ras-association domain family 1 isoform A is a novel regulator of cardiac hypertrophy. Circulation. 2009 Aug 18; 120(7):607-16.
Oceandy D, Pickard A, Prehar S, Zi M, Mohamed TM, Stanley PJ, Baudoin-Stanley F, Nadif R, Tommasi S, Pfeifer GP, Armesilla AL, Cartwright EJ, Neyses L. PMID: 19652091.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Methylation of homeobox genes is a frequent and early epigenetic event in breast cancer. Breast Cancer Res. 2009; 11(1):R14.
Tommasi S, Karm DL, Wu X, Yen Y, Pfeifer GP. PMID: 19250546; PMCID: PMC2687719.
View in:
PubMed Mentions:
77 Fields:
Translation:
HumansCells
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RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network. Curr Biol. 2007 Apr 17; 17(8):700-5.
Guo C, Tommasi S, Liu L, Yee JK, Dammann R, Pfeifer GP. PMID: 17379520.
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PubMed Mentions:
94 Fields:
Translation:
HumansAnimalsCells
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Involvement of the RASSF1A tumor suppressor gene in controlling cell migration. Cancer Res. 2005 Sep 01; 65(17):7653-9.
Dallol A, Agathanggelou A, Tommasi S, Pfeifer GP, Maher ER, Latif F. PMID: 16140931.
View in:
PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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Short hairpin RNA-directed cytosine (CpG) methylation of the RASSF1A gene promoter in HeLa cells. Mol Ther. 2005 Jul; 12(1):179-83.
Castanotto D, Tommasi S, Li M, Li H, Yanow S, Pfeifer GP, Rossi JJ. PMID: 15963934.
View in:
PubMed Mentions:
60 Fields:
Translation:
HumansCells
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The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death. Mol Cell. 2005 Jun 10; 18(6):637-50.
Baksh S, Tommasi S, Fenton S, Yu VC, Martins LM, Pfeifer GP, Latif F, Downward J, Neel BG. PMID: 15949439.
View in:
PubMed Mentions:
78 Fields:
Translation:
HumansCells
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Tumor susceptibility of Rassf1a knockout mice. Cancer Res. 2005 Jan 01; 65(1):92-8.
Tommasi S, Dammann R, Zhang Z, Wang Y, Liu L, Tsark WM, Wilczynski SP, Li J, You M, Pfeifer GP. PMID: 15665283.
View in:
PubMed Mentions:
91 Fields:
Translation:
AnimalsCells
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Control of microtubule stability by the RASSF1A tumor suppressor. Oncogene. 2003 Nov 06; 22(50):8125-36.
Liu L, Tommasi S, Lee DH, Dammann R, Pfeifer GP. PMID: 14603253.
View in:
PubMed Mentions:
69 Fields:
Translation:
AnimalsCells
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Epigenetic inactivation of RAS association domain family protein 1 (RASSF1A) in malignant cutaneous melanoma. Cancer Res. 2003 Apr 01; 63(7):1639-43.
Spugnardi M, Tommasi S, Dammann R, Pfeifer GP, Hoon DS. PMID: 12670917.
View in:
PubMed Mentions:
54 Fields:
Translation:
HumansCells
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Methylation of the RASSF1A gene in human cancers. Biol Chem. 2002 Jun; 383(6):907-14.
Pfeifer GP, Yoon JH, Liu L, Tommasi S, Wilczynski SP, Dammann R. PMID: 12222680.
View in:
PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
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RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1. Oncogene. 2002 Apr 18; 21(17):2713-20.
Tommasi S, Dammann R, Jin SG, Zhang XF, Avruch J, Pfeifer GP. PMID: 11965544.
View in:
PubMed Mentions:
33 Fields:
Translation:
HumansCells