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Gangning Liang, MD, PhD

Title(s)Professor of Research Urology
AddressNOR 7338
Health Sciences Campus
Los Angeles CA 90089-9176
Phone+1 323 865 0470
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    Other Positions
    Title(s)Director of Epigenetic Translational Research of the USC Institute of Urology.


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    Dr. Gangning Liang is a Professor of Department of Urology and Director of Epigenetic Translational Research of USC Institute of Urology at Norris Comprehensive Cancer Center. He obtained his MD degree from Shanghai Second Medical School in 1985 and received PhD degree from Department of Pharmaceutical Science in University of Nebraska Medical Center in 1995. He was appointed Assistant Professor in 1998, Associate Professor in 2008, and Professor in 2016 in USC Norris Comprehensive Cancer Center. He completed a postdoctoral training in Epigenetics with Dr. Peter A. Jones 1995-1998 at USC. His research interests include investigating epigenome structures, epigenomic alterations during tumorigenesis, and epigenetic alterations induced by drug treatment in cancer therapies. As PI, multiple-PI, and co-Investigator over 10 NIH-funded grants, his research has laid the groundwork for the proposed research project including the roles of DNA methyltransferases (DNMTs) and microRNAs during tumorigenesis and novel methods of characterizing epigenetic changes and monitoring these changes in patients. In this regard, he has identified epigenetic alterations in urine sediments for bladder cancer-based diagnostic and prognostic purposes, more recently he also is also developing similar assay in kidney and prostate cancer, as well as introducing epigenetic therapy for cancer treatment in preclinical models. He is currently using these techniques and models, which he developed, to not only to further study the role of epigenetic regulation during tumorigenesis, but also to establish new translational projects that directly address clinical questions. He is focusing on his translational research to use epigenetic alteration as foundation to identify drug targets in a selective and predictable way for precision cancer medicine and to improve in patient survival and quality of life. He published extensively in journals including Cell, Cancer Cell, Molecular Cell, Genome Research, Hepatology, Nature Communications, Genome Biology, PNAS, Cancer Research, and Oncogene with over 100 peer reviewed articles.

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    Using DNA methylation markers to improve the predictive accuracy and utility of needle biopsiesfor determining prostate cancer aggressiveness
    NIH/NCI R21CA201865Jul 1, 2016 - Jun 30, 2018
    Role: Principal Investigator
    Identification of a sensitive and specific panel of DNA methylated markers to imp
    NIH/NCI R21CA167367Jul 10, 2012 - Jun 30, 2014
    Role: Principal Investigator
    Determining the mechanistic and therapeutic roles of microRNAs in bladder cancer
    NIH/NCI R01CA138794Aug 9, 2010 - Jun 30, 2014
    Role: Principal Investigator
    Epigentic Alterations in Pre-malignant Tissue of the Bladder
    NIH/NCI R01CA124518Sep 24, 2008 - Jul 31, 2014
    Role: Principal Investigator
    De Novo DNA Methylation in Bladder Cancer
    NIH/NCI R01CA083867Mar 1, 2000 - Jun 30, 2010
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Epigenetic plasticity potentiates a rapid cyclical shift to and from an aggressive cancer phenotype. Int J Cancer. 2020 Jun 01; 146(11):3065-3076. Xu T, Li HT, Wei J, Li M, Hsieh TC, Lu YT, Lakshminarasimhan R, Xu R, Hodara E, Morrison G, Gujar H, Rhie SK, Siegmund K, Liang G, Goldkorn A. PMID: 32017074.
      View in: PubMed   Mentions:    Fields:    
    2. Telomerase Variants in Patients with Cirrhosis Awaiting Liver Transplantation. Hepatology. 2019 06; 69(6):2652-2663. Chiu V, Hogen R, Sher L, Wadé N, Conti D, Martynova A, Li H, Liang G, O'Connell C. PMID: 30964210.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    3. AMPK variant, a candidate of novel predictor for chemotherapy in metastatic colorectal cancer: A meta-analysis using TRIBE, MAVERICC and FIRE3. Int J Cancer. 2019 10 15; 145(8):2082-2090. Tokunaga R, Cao S, Naseem M, Battaglin F, Lo JH, Arai H, Loupakis F, Stintzing S, Puccini A, Berger MD, Soni S, Zhang W, Mancao C, Salhia B, Mumenthaler SM, Weisenberger DJ, Liang G, Cremolini C, Heinemann V, Falcone A, Millstein J, Lenz HJ. PMID: 30856283.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Impact of polymorphisms within genes involved in regulating DNA methylation in patients with metastatic colorectal cancer enrolled in three independent, randomised, open-label clinical trials: a meta-analysis from TRIBE, MAVERICC and FIRE-3. Eur J Cancer. 2019 04; 111:138-147. Puccini A, Loupakis F, Stintzing S, Cao S, Battaglin F, Togunaka R, Naseem M, Berger MD, Soni S, Zhang W, Mancao C, Salhia B, Mumenthaler SM, Weisenberger DJ, Liang G, Cremolini C, Heinemann V, Falcone A, Millstein J, Lenz HJ. PMID: 30852420.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. The Roles of Human DNA Methyltransferases and Their Isoforms in Shaping the Epigenome. Genes (Basel). 2019 02 23; 10(2). Gujar H, Weisenberger DJ, Liang G. PMID: 30813436.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    6. Data integration by multi-tuning parameter elastic net regression. BMC Bioinformatics. 2018 Oct 10; 19(1):369. Liu J, Liang G, Siegmund KD, Lewinger JP. PMID: 30305021.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Integrative Epigenetic Analysis Reveals Therapeutic Targets to the DNA Methyltransferase Inhibitor Guadecitabine (SGI-110) in Hepatocellular Carcinoma. Hepatology. 2018 10; 68(4):1412-1428. Liu M, Zhang L, Li H, Hinoue T, Zhou W, Ohtani H, El-Khoueiry A, Daniels J, O'Connell C, Dorff TB, Lu Q, Weisenberger DJ, Liang G. PMID: 29774579.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    8. Quantitative Contour Analysis as an Image-based Discriminator Between Benign and Malignant Renal Tumors. Urology. 2018 Apr; 114:121-127. Yap FY, Hwang DH, Cen SY, Varghese BA, Desai B, Quinn BD, Gupta MN, Rajarubendra N, Desai MM, Aron M, Liang G, Aron M, Gill IS, Duddalwar VA. PMID: 29305199.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    9. DNA methylation aberrancies delineate clinically distinct subsets of colorectal cancer and provide novel targets for epigenetic therapies. Oncogene. 2018 02 01; 37(5):566-577. Weisenberger DJ, Liang G, Lenz HJ. PMID: 28991233.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    10. Down-regulation of ARID1A is sufficient to initiate neoplastic transformation along with epigenetic reprogramming in non-tumorigenic endometriotic cells. Cancer Lett. 2017 08 10; 401:11-19. Lakshminarasimhan R, Andreu-Vieyra C, Lawrenson K, Duymich CE, Gayther SA, Liang G, Jones PA. PMID: 28483516.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    11. DNA methylation aberrancies as a guide for surveillance and treatment of human cancers. Epigenetics. 2017 06 03; 12(6):416-432. Liang G, Weisenberger DJ. PMID: 28358281.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    12. epiG: statistical inference and profiling of DNA methylation from whole-genome bisulfite sequencing data. Genome Biol. 2017 02 21; 18(1):38. Vincent M, Mundbjerg K, Skou Pedersen J, Liang G, Jones PA, Ørntoft TF, Dalsgaard Sørensen K, Wiuf C. PMID: 28222791.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    13. Nucleosome Positioning and NDR Structure at RNA Polymerase III Promoters. Sci Rep. 2017 02 08; 7:41947. Helbo AS, Lay FD, Jones PA, Liang G, Grønbæk K. PMID: 28176797.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    14. Improving needle biopsy accuracy in small renal mass using tumor-specific DNA methylation markers. Oncotarget. 2017 Jan 17; 8(3):5439-5448. Chopra S, Liu J, Alemozaffar M, Nichols PW, Aron M, Weisenberger DJ, Collings CK, Syan S, Hu B, Desai M, Aron M, Duddalwar V, Gill I, Liang G, Siegmund KD. PMID: 27690297.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    15. Heterogeneous patterns of DNA methylation-based field effects in histologically normal prostate tissue from cancer patients. Sci Rep. 2017 01 13; 7:40636. Møller M, Strand SH, Mundbjerg K, Liang G, Gill I, Haldrup C, Borre M, Høyer S, Ørntoft TF, Sørensen KD. PMID: 28084441.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    16. Identifying aggressive prostate cancer foci using a DNA methylation classifier. Genome Biol. 2017 01 12; 18(1):3. Mundbjerg K, Chopra S, Alemozaffar M, Duymich C, Lakshminarasimhan R, Nichols PW, Aron M, Siegmund KD, Ukimura O, Aron M, Stern M, Gill P, Carpten JD, Ørntoft TF, Sørensen KD, Weisenberger DJ, Jones PA, Duddalwar V, Gill I, Liang G. PMID: 28081708.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    17. Genetic and Epigenetic Alterations in Bladder Cancer. Int Neurourol J. 2016 Nov; 20(Suppl 2):S84-94. Li HT, Duymich CE, Weisenberger DJ, Liang G. PMID: 27915480.
      View in: PubMed   Mentions:
    18. Vitamin C increases viral mimicry induced by 5-aza-2'-deoxycytidine. Proc Natl Acad Sci U S A. 2016 09 13; 113(37):10238-44. Liu M, Ohtani H, Zhou W, Ørskov AD, Charlet J, Zhang YW, Shen H, Baylin SB, Liang G, Grønbæk K, Jones PA. PMID: 27573823.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    19. Bivalent Regions of Cytosine Methylation and H3K27 Acetylation Suggest an Active Role for DNA Methylation at Enhancers. Mol Cell. 2016 05 05; 62(3):422-431. Charlet J, Duymich CE, Lay FD, Mundbjerg K, Dalsgaard Sørensen K, Liang G, Jones PA. PMID: 27153539.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    20. DNMT3B isoforms without catalytic activity stimulate gene body methylation as accessory proteins in somatic cells. Nat Commun. 2016 04 28; 7:11453. Duymich CE, Charlet J, Yang X, Jones PA, Liang G. PMID: 27121154.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    21. Isoform switching and exon skipping induced by the DNA methylation inhibitor 5-Aza-2'-deoxycytidine. Sci Rep. 2016 Apr 19; 6:24545. Ding XL, Yang X, Liang G, Wang K. PMID: 27090213.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    22. Identification of DNA Methylation-Independent Epigenetic Events Underlying Clear Cell Renal Cell Carcinoma. Cancer Res. 2016 04 01; 76(7):1954-64. Becket E, Chopra S, Duymich CE, Lin JJ, You JS, Pandiyan K, Nichols PW, Siegmund KD, Charlet J, Weisenberger DJ, Jones PA, Liang G. PMID: 26759245.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    23. The Role of DNA Methylation in Cancer. Adv Exp Med Biol. 2016; 945:151-172. Lakshminarasimhan R, Liang G. PMID: 27826838.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    24. Linker histone H1.2 establishes chromatin compaction and gene silencing through recognition of H3K27me3. Sci Rep. 2015 Nov 19; 5:16714. Kim JM, Kim K, Punj V, Liang G, Ulmer TS, Lu W, An W. PMID: 26581166.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    25. Hypermethylation of the VTRNA1-3 Promoter is Associated with Poor Outcome in Lower Risk Myelodysplastic Syndrome Patients. Genes (Basel). 2015 Oct 14; 6(4):977-90. Helbo AS, Treppendahl M, Aslan D, Dimopoulos K, Nandrup-Bus C, Holm MS, Andersen MK, Liang G, Kristensen LS, Grønbæk K. PMID: 26473932.
      View in: PubMed   Mentions: 6     Fields:    
    26. CT prediction of the Fuhrman grade of clear cell renal cell carcinoma (RCC): towards the development of computer-assisted diagnostic method. Abdom Imaging. 2015 Oct; 40(8):3168-74. Huhdanpaa H, Hwang D, Cen S, Quinn B, Nayyar M, Zhang X, Chen F, Desai B, Liang G, Gill I, Duddalwar V. PMID: 26304585.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. Unique Role for a DNA Methyltransferase Isoform in Lung Cancer. EBioMedicine. 2015 Oct; 2(10):1272-3. Duymich CE, Liang G. PMID: 26629503.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    28. DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts. Cell. 2015 Aug 27; 162(5):961-73. Roulois D, Loo Yau H, Singhania R, Wang Y, Danesh A, Shen SY, Han H, Liang G, Jones PA, Pugh TJ, O'Brien C, De Carvalho DD. PMID: 26317465.
      View in: PubMed   Mentions: 223     Fields:    Translation:HumansAnimalsCells
    29. Outlining the limits of partial nephrectomy. Transl Androl Urol. 2015 Jun; 4(3):294-300. Chopra S, Satkunasivam R, Kundavaram C, Liang G, Gill IS. PMID: 26236649.
      View in: PubMed   Mentions:
    30. Epigenetic alterations and microRNA misexpression in cancer and autoimmune diseases: a critical review. Clin Rev Allergy Immunol. 2014 Oct; 47(2):128-35. Saito Y, Saito H, Liang G, Friedman JM. PMID: 24362548.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    31. Gene body methylation can alter gene expression and is a therapeutic target in cancer. Cancer Cell. 2014 Oct 13; 26(4):577-90. Yang X, Han H, De Carvalho DD, Lay FD, Jones PA, Liang G. PMID: 25263941.
      View in: PubMed   Mentions: 242     Fields:    Translation:HumansCells
    32. A panel of three markers hyper- and hypomethylated in urine sediments accurately predicts bladder cancer recurrence. Clin Cancer Res. 2014 Apr 01; 20(7):1978-89. Su SF, de Castro Abreu AL, Chihara Y, Tsai Y, Andreu-Vieyra C, Daneshmand S, Skinner EC, Jones PA, Siegmund KD, Liang G. PMID: 24691641.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    33. Reprogramming of the human intestinal epigenome by surgical tissue transposition. Genome Res. 2014 Apr; 24(4):545-53. Lay FD, Triche TJ, Tsai YC, Su SF, Martin SE, Daneshmand S, Skinner EC, Liang G, Chihara Y, Jones PA. PMID: 24515120.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    34. Synergistic re-activation of epigenetically silenced genes by combinatorial inhibition of DNMTs and LSD1 in cancer cells. PLoS One. 2013; 8(9):e75136. Han H, Yang X, Pandiyan K, Liang G. PMID: 24040395.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    35. Alterations in deoxyribonucleic acid (DNA) methylation patterns of Calca, Timp3, Mmp2, and Igf2r are associated with chronic cystitis in a cyclophosphamide-induced mouse model. Urology. 2013 Jul; 82(1):253.e9-15. Choi IS, Yu K, Kim J, De Guzman E, Weisenberger DJ, Oghamian S, Kim HJ, Lee KH, Carroll C, Trinh BN, Kim M, Houshdaran S, Laird PW, Jones PA, Warburton D, Liang G, Koh CJ. PMID: 23806407.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    36. Diagnostic markers of urothelial cancer based on DNA methylation analysis. BMC Cancer. 2013 Jun 04; 13:275. Chihara Y, Kanai Y, Fujimoto H, Sugano K, Kawashima K, Liang G, Jones PA, Fujimoto K, Kuniyasu H, Hirao Y. PMID: 23735005.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    37. SNF5 is an essential executor of epigenetic regulation during differentiation. PLoS Genet. 2013 Apr; 9(4):e1003459. You JS, De Carvalho DD, Dai C, Liu M, Pandiyan K, Zhou XJ, Liang G, Jones PA. PMID: 23637628.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    38. Functional DNA demethylation is accompanied by chromatin accessibility. Nucleic Acids Res. 2013 Apr; 41(7):3973-85. Pandiyan K, You JS, Yang X, Dai C, Zhou XJ, Baylin SB, Jones PA, Liang G. PMID: 23408854.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    39. Nucleosome occupancy and gene regulation during tumorigenesis. Adv Exp Med Biol. 2013; 754:109-34. Andreu-Vieyra CV, Liang G. PMID: 22956498.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    40. miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer. Oncogene. 2013 Sep 26; 32(39):4694-701. Su SF, Chang YW, Andreu-Vieyra C, Fang JY, Yang Z, Han B, Lee AS, Liang G. PMID: 23085757.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    41. Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules. Genome Res. 2012 Dec; 22(12):2497-506. Kelly TK, Liu Y, Lay FD, Liang G, Berman BP, Jones PA. PMID: 22960375.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansCells
    42. Epigenetic alterations in bladder cancer and their potential clinical implications. Adv Urol. 2012; 2012:546917. Han H, Wolff EM, Liang G. PMID: 22829811.
      View in: PubMed   Mentions:
    43. DNA methylation screening identifies driver epigenetic events of cancer cell survival. Cancer Cell. 2012 May 15; 21(5):655-67. De Carvalho DD, Sharma S, You JS, Su SF, Taberlay PC, Kelly TK, Yang X, Liang G, Jones PA. PMID: 22624715.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansCells
    44. Gene reactivation by 5-aza-2'-deoxycytidine-induced demethylation requires SRCAP-mediated H2A.Z insertion to establish nucleosome depleted regions. PLoS Genet. 2012; 8(3):e1002604. Yang X, Noushmehr H, Han H, Andreu-Vieyra C, Liang G, Jones PA. PMID: 22479200.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    45. Lysine methyltransferase G9a is not required for DNMT3A/3B anchoring to methylated nucleosomes and maintenance of DNA methylation in somatic cells. Epigenetics Chromatin. 2012 Jan 27; 5(1):3. Sharma S, Gerke DS, Han HF, Jeong S, Stallcup MR, Jones PA, Liang G. PMID: 22284370.
      View in: PubMed   Mentions: 8     Fields:    
    46. Polycomb-repressed genes have permissive enhancers that initiate reprogramming. Cell. 2011 Dec 09; 147(6):1283-94. Taberlay PC, Kelly TK, Liu CC, You JS, De Carvalho DD, Miranda TB, Zhou XJ, Liang G, Jones PA. PMID: 22153073.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    47. Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML. Blood. 2012 Jan 05; 119(1):206-16. Treppendahl MB, Qiu X, Søgaard A, Yang X, Nandrup-Bus C, Hother C, Andersen MK, Kjeldsen L, Möllgård L, Möllgaard L, Hellström-Lindberg E, Jendholm J, Porse BT, Jones PA, Liang G, Grønbæk K. PMID: 22058117.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    48. OCT4 establishes and maintains nucleosome-depleted regions that provide additional layers of epigenetic regulation of its target genes. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14497-502. You JS, Kelly TK, De Carvalho DD, Taberlay PC, Liang G, Jones PA. PMID: 21844352.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    49. DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter. Hum Mol Genet. 2011 Nov 15; 20(22):4299-310. Han H, Cortez CC, Yang X, Nichols PW, Jones PA, Liang G. PMID: 21835883.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    50. Creating a flexible multiple microRNA expression vector by linking precursor microRNAs. Biochem Biophys Res Commun. 2011 Jul 29; 411(2):276-80. Qiu X, Friedman JM, Liang G. PMID: 21726537.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    51. Conditional inactivation of the CXCR4 receptor in osteoprecursors reduces postnatal bone formation due to impaired osteoblast development. J Biol Chem. 2011 Jul 29; 286(30):26794-805. Zhu W, Liang G, Huang Z, Doty SB, Boskey AL. PMID: 21636574.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    52. Epigenetic reprogramming as a key contributor to melanocyte malignant transformation. Epigenetics. 2011 Apr; 6(4):450-64. Molognoni F, Cruz AT, Meliso FM, Morais AS, Souza CF, Xander P, Bischof JM, Costa FF, Soares MB, Liang G, Jones PA, Jasiulionis MG. PMID: 21343701.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    53. Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance. PLoS Genet. 2011 Feb 03; 7(2):e1001286. Sharma S, De Carvalho DD, Jeong S, Jones PA, Liang G. PMID: 21304883.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    54. Equitoxic doses of 5-azacytidine and 5-aza-2'deoxycytidine induce diverse immediate and overlapping heritable changes in the transcriptome. PLoS One. 2010 Sep 29; 5(9). Qiu X, Hother C, Ralfkiær UM, Søgaard A, Lu Q, Workman CT, Liang G, Jones PA, Grønbæk K. PMID: 20927380.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    55. H2A.Z maintenance during mitosis reveals nucleosome shifting on mitotically silenced genes. Mol Cell. 2010 Sep 24; 39(6):901-11. Kelly TK, Miranda TB, Liang G, Berman BP, Lin JC, Tanay A, Jones PA. PMID: 20864037.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    56. Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue. Cancer Res. 2010 Oct 15; 70(20):8169-78. Wolff EM, Chihara Y, Pan F, Weisenberger DJ, Siegmund KD, Sugano K, Kawashima K, Laird PW, Jones PA, Liang G. PMID: 20841482.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    57. Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer. PLoS Genet. 2010 Apr 22; 6(4):e1000917. Wolff EM, Byun HM, Han HF, Sharma S, Nichols PW, Siegmund KD, Yang AS, Jones PA, Liang G. PMID: 20421991.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansCells
    58. Tissue inhibitor of metalloproteinase 1 expression associated with gene demethylation confers anoikis resistance in early phases of melanocyte malignant transformation. Transl Oncol. 2009 Dec; 2(4):329-40. Ricca TI, Liang G, Suenaga AP, Han SW, Jones PA, Jasiulionis MG. PMID: 19956395.
      View in: PubMed   Mentions:
    59. Rethinking how DNA methylation patterns are maintained. Nat Rev Genet. 2009 11; 10(11):805-11. Jones PA, Liang G. PMID: 19789556.
      View in: PubMed   Mentions: 231     Fields:    Translation:HumansAnimalsCells
    60. The tumor suppressor microRNA-101 becomes an epigenetic player by targeting the polycomb group protein EZH2 in cancer. Cell Cycle. 2009 Aug; 8(15):2313-4. Friedman JM, Jones PA, Liang G. PMID: 19625769.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    61. Changes in DNA methylation of tandem DNA repeats are different from interspersed repeats in cancer. Int J Cancer. 2009 Aug 01; 125(3):723-9. Choi SH, Worswick S, Byun HM, Shear T, Soussa JC, Wolff EM, Douer D, Garcia-Manero G, Liang G, Yang AS. PMID: 19437537.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    62. Selective anchoring of DNA methyltransferases 3A and 3B to nucleosomes containing methylated DNA. Mol Cell Biol. 2009 Oct; 29(19):5366-76. Jeong S, Liang G, Sharma S, Lin JC, Choi SH, Han H, Yoo CB, Egger G, Yang AS, Jones PA. PMID: 19620278.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    63. DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. Mol Cancer Ther. 2009 Jun; 8(6):1579-88. Miranda TB, Cortez CC, Yoo CB, Liang G, Abe M, Kelly TK, Marquez VE, Jones PA. PMID: 19509260.
      View in: PubMed   Mentions: 206     Fields:    Translation:HumansCells
    64. The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2. Cancer Res. 2009 Mar 15; 69(6):2623-9. Friedman JM, Liang G, Liu CC, Wolff EM, Tsai YC, Ye W, Zhou X, Jones PA. PMID: 19258506.
      View in: PubMed   Mentions: 162     Fields:    Translation:HumansCells
    65. Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells. Biochem Biophys Res Commun. 2009 Feb 13; 379(3):726-31. Saito Y, Friedman JM, Chihara Y, Egger G, Chuang JC, Liang G. PMID: 19116145.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansCells
    66. Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):12979-84. Gal-Yam EN, Egger G, Iniguez L, Holster H, Einarsson S, Zhang X, Lin JC, Liang G, Jones PA, Tanay A. PMID: 18753622.
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    67. RUNX3 methylation reveals that bladder tumors are older in patients with a history of smoking. Cancer Res. 2008 Aug 01; 68(15):6208-14. Wolff EM, Liang G, Cortez CC, Tsai YC, Castelao JE, Cortessis VK, Tsao-Wei DD, Groshen S, Jones PA. PMID: 18676844.
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    68. DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight. Nucleic Acids Res. 2008 Aug; 36(14):4689-98. Weisenberger DJ, Trinh BN, Campan M, Sharma S, Long TI, Ananthnarayan S, Liang G, Esteva FJ, Hortobagyi GN, McCormick F, Jones PA, Laird PW. PMID: 18628296.
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    69. Examination of IGF2 and H19 loss of imprinting in bladder cancer. Cancer Res. 2007 Nov 15; 67(22):10753-8. Byun HM, Wong HL, Birnstein EA, Wolff EM, Liang G, Yang AS. PMID: 18006818.
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    70. Role of nucleosomal occupancy in the epigenetic silencing of the MLH1 CpG island. Cancer Cell. 2007 Nov; 12(5):432-44. Lin JC, Jeong S, Liang G, Takai D, Fatemi M, Tsai YC, Egger G, Gal-Yam EN, Jones PA. PMID: 17996647.
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    71. Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides. Cancer Res. 2007 Jul 01; 67(13):6400-8. Yoo CB, Jeong S, Egger G, Liang G, Phiasivongsa P, Tang C, Redkar S, Jones PA. PMID: 17616700.
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    72. Methylation-sensitive single-nucleotide primer extension (Ms-SNuPE) for quantitative measurement of DNA methylation. Nat Protoc. 2007; 2(8):1931-6. Gonzalgo ML, Liang G. PMID: 17703204.
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    73. Locus-wide chromatin remodeling and enhanced androgen receptor-mediated transcription in recurrent prostate tumor cells. Mol Cell Biol. 2006 Oct; 26(19):7331-41. Jia L, Shen HC, Wantroba M, Khalid O, Liang G, Wang Q, Gentzschein E, Pinski JK, Stanczyk FZ, Jones PA, Coetzee GA. PMID: 16980632.
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    74. Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival. Proc Natl Acad Sci U S A. 2006 Sep 19; 103(38):14080-5. Egger G, Jeong S, Escobar SG, Cortez CC, Li TW, Saito Y, Yoo CB, Jones PA, Liang G. PMID: 16963560.
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    75. Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell. 2006 Jun; 9(6):435-43. Saito Y, Liang G, Egger G, Friedman JM, Chuang JC, Coetzee GA, Jones PA. PMID: 16766263.
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    76. Prognostic relevance of methylation markers in patients with non-muscle invasive bladder carcinoma. Eur J Cancer. 2005 Nov; 41(17):2769-78. Friedrich MG, Chandrasoma S, Siegmund KD, Weisenberger DJ, Cheng JC, Toma MI, Huland H, Jones PA, Liang G. PMID: 16242928.
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    77. Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer. Nat Clin Pract Urol. 2005 Oct; 2(10):502-10. Wolff EM, Liang G, Jones PA. PMID: 16474624.
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    78. Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine. Mol Cancer Ther. 2005 Oct; 4(10):1515-20. Chuang JC, Yoo CB, Kwan JM, Li TW, Liang G, Yang AS, Jones PA. PMID: 16227400.
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    79. Detection of methylated apoptosis-associated genes in urine sediments of bladder cancer patients. Clin Cancer Res. 2004 Nov 15; 10(22):7457-65. Friedrich MG, Weisenberger DJ, Cheng JC, Chandrasoma S, Siegmund KD, Gonzalgo ML, Toma MI, Huland H, Yoo C, Tsai YC, Nichols PW, Bochner BH, Jones PA, Liang G. PMID: 15569975.
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    80. Preferential response of cancer cells to zebularine. Cancer Cell. 2004 Aug; 6(2):151-8. Cheng JC, Yoo CB, Weisenberger DJ, Chuang J, Wozniak C, Liang G, Marquez VE, Greer S, Orntoft TF, Thykjaer T, Jones PA. PMID: 15324698.
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    81. Epigenetics in human disease and prospects for epigenetic therapy. Nature. 2004 May 27; 429(6990):457-63. Egger G, Liang G, Aparicio A, Jones PA. PMID: 15164071.
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    82. Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7357-62. Liang G, Lin JC, Wei V, Yoo C, Cheng JC, Nguyen CT, Weisenberger DJ, Egger G, Takai D, Gonzales FA, Jones PA. PMID: 15123803.
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    83. Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells. Mol Cell Biol. 2004 Feb; 24(3):1270-8. Cheng JC, Weisenberger DJ, Gonzales FA, Liang G, Xu GL, Hu YG, Marquez VE, Jones PA. PMID: 14729971.
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    84. Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation. Mol Cancer Res. 2004 Jan; 2(1):62-72. Weisenberger DJ, Velicescu M, Cheng JC, Gonzales FA, Liang G, Jones PA. PMID: 14757847.
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    85. Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine. Cancer Res. 2002 Nov 15; 62(22):6456-61. Nguyen CT, Weisenberger DJ, Velicescu M, Gonzales FA, Lin JC, Liang G, Jones PA. PMID: 12438235.
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    86. Hypomethylation and hypermethylation of DNA in Wilms tumors. Oncogene. 2002 Sep 26; 21(43):6694-702. Ehrlich M, Jiang G, Fiala E, Dome JS, Yu MC, Long TI, Youn B, Sohn OS, Widschwendter M, Tomlinson GE, Chintagumpala M, Champagne M, Parham D, Liang G, Malik K, Laird PW. PMID: 12242669.
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    87. Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells. Gene. 2002 Sep 18; 298(1):91-9. Weisenberger DJ, Velicescu M, Preciado-Lopez MA, Gonzales FA, Tsai YC, Liang G, Jones PA. PMID: 12406579.
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    88. Identification of DNA methylation differences during tumorigenesis by methylation-sensitive arbitrarily primed polymerase chain reaction. Methods. 2002 Jun; 27(2):150-5. Liang G, Gonzalgo ML, Salem C, Jones PA. PMID: 12095274.
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    89. Analysis of gene induction in human fibroblasts and bladder cancer cells exposed to the methylation inhibitor 5-aza-2'-deoxycytidine. Cancer Res. 2002 Feb 15; 62(4):961-6. Liang G, Gonzales FA, Jones PA, Orntoft TF, Thykjaer T. PMID: 11861364.
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    90. Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol Cell Biol. 2002 Jan; 22(2):480-91. Liang G, Chan MF, Tomigahara Y, Tsai YC, Gonzales FA, Li E, Laird PW, Jones PA. PMID: 11756544.
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    91. Susceptibility of nonpromoter CpG islands to de novo methylation in normal and neoplastic cells. J Natl Cancer Inst. 2001 Oct 03; 93(19):1465-72. Nguyen C, Liang G, Nguyen TT, Tsao-Wei D, Groshen S, Lübbert M, Zhou JH, Benedict WF, Jones PA. PMID: 11584062.
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    92. Global and gene-specific epigenetic patterns in human bladder cancer genomes are relatively stable in vivo and in vitro over time. Cancer Res. 2001 Aug 01; 61(15):5875-84. Markl ID, Cheng J, Liang G, Shibata D, Laird PW, Jones PA. PMID: 11479229.
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    93. The endothelin receptor B (EDNRB) promoter displays heterogeneous, site specific methylation patterns in normal and tumor cells. Hum Mol Genet. 2001 Apr 15; 10(9):903-10. Pao MM, Tsutsumi M, Liang G, Uzvolgyi E, Gonzales FA, Jones PA. PMID: 11309363.
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    94. The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells. Cancer Res. 2000 Sep 01; 60(17):4907-12. Liang G, Robertson KD, Talmadge C, Sumegi J, Jones PA. PMID: 10987305.
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    95. PAX6 methylation and ectopic expression in human tumor cells. Int J Cancer. 2000 Jul 15; 87(2):179-85. Salem CE, Markl ID, Bender CM, Gonzales FA, Jones PA, Liang G. PMID: 10861471.
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    96. Progressive increases in de novo methylation of CpG islands in bladder cancer. Cancer Res. 2000 May 01; 60(9):2473-6. Salem C, Liang G, Tsai YC, Coulter J, Knowles MA, Feng AC, Groshen S, Nichols PW, Jones PA. PMID: 10811126.
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    97. DNA methylator and mismatch repair phenotypes are not mutually exclusive in colorectal cancer cell lines. Oncogene. 2000 Feb 17; 19(7):943-52. Pao MM, Liang G, Tsai YC, Xiong Z, Laird PW, Jones PA. PMID: 10702803.
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    98. Relationship between transcription and DNA methylation. Curr Top Microbiol Immunol. 2000; 249:75-86. Chan MF, Liang G, Jones PA. PMID: 10802939.
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    99. The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res. 1999 Jun 01; 27(11):2291-8. Robertson KD, Uzvolgyi E, Liang G, Talmadge C, Sumegi J, Gonzales FA, Jones PA. PMID: 10325416.
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    100. Novel endothelin B receptor transcripts with the potential of generating a new receptor. Gene. 1999 Mar 04; 228(1-2):43-9. Tsutsumi M, Liang G, Jones PA. PMID: 10072757.
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    101. DNA methylation differences associated with tumor tissues identified by genome scanning analysis. Genomics. 1998 Nov 01; 53(3):260-8. Liang G, Salem CE, Yu MC, Nguyen HD, Gonzales FA, Nguyen TT, Nichols PW, Jones PA. PMID: 9799591.
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    102. Regioselective effect of zwitterionic DNA substitutions on DNA alkylation: evidence for a strong side chain orientational preference. Biochemistry. 1997 May 20; 36(20):6024-32. Dande P, Liang G, Chen FX, Roberts C, Nelson MG, Hashimoto H, Switzer C, Gold B. PMID: 9166773.
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    103. Identification and characterization of differentially methylated regions of genomic DNA by methylation-sensitive arbitrarily primed PCR. Cancer Res. 1997 Feb 15; 57(4):594-9. Gonzalgo ML, Liang G, Spruck CH, Zingg JM, Rideout WM, Jones PA. PMID: 9044832.
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    104. Reaction of N-(2-chloroethyl)-N-nitrosoureas with DNA: effect of buffers on DNA adduction, cross-linking, and cytotoxicity. Chem Res Toxicol. 1996 Jan-Feb; 9(1):208-14. Chen FX, Bodell WJ, Liang G, Gold B. PMID: 8924592.
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    105. The use of 2-hydroperoxytetrahydrofuran as a reagent to sequence cytosine and to probe non-Watson-Crick DNA structures. Nucleic Acids Res. 1995 Feb 25; 23(4):713-9. Liang G, Gannett P, Gold B. PMID: 7899093.
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