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David E. Cobrinik, MD, PhD

Title(s)Associate Professor of Research Ophthalmology
AddressCHL 4650 W Sunset Blvd
Off Campus
Los Angeles CA 90027
Phone+1 323 361 2275
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    Collapse Biography 
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    1996  - 1999James S. McDonnell Foundation Scholar
    1992  - 1995Susan G. Komen Breast Cancer Foundation Postdoctoral Fellow
    1989  - 1992American Cancer Society Postdoctoral Fellow
    1983American Cancer Society Joseph S. Silber Pre-doctoral Fellow
    1982Oscar E. Schotté Award for Biological Research, Amherst College

    Collapse Overview 
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    Our research seeks to improve understanding of retinal development and its relationship to retinal diseases. This goal stems from my long interest in a childhood retinal tumor called retinoblastoma, a cancer that develops in response to inactivation of the RB1 tumor suppressor gene and loss of functional pRB protein. One of our goals is to understand why cells of the retina but not other tissues routinely form cancers in response to pRB loss, and to use this knowledge to develop more effective therapies for retinoblastoma and other RB1-mutant cancers. We recently found that retinoblastomas arise from cone photoreceptor precursors, and that cone precursor-specific proliferation-related signaling pathways collaborate with pRB loss to enable tumorigenesis. This finding suggests that cone precursors signaling pathways can be targeted to suppress retinoblastoma development. Current studies aim to 1) define developmental signaling pathways that sensitize retinal cells to Rb loss, 2) define the step-by-step events through which Rb loss converts normal retinal cells to malignant retinoblastomas, and 3) target novel vulnerabilities in the pRB-deficient cone precursor circuitry.

    With our colleagues at the CHLA Vision Center we also model retinal development and diseases using human pluripotent stem cells. We can produce normal-appearing developing retinas in vitro, opening the door to previously unimagined vision research opportunities. Current efforts aim to define similarities and differences between human retina produced in vitro and in vivo, and to thereby improve the verisimilitude of the in vitro retinal development model.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chromosome 6p amplification in aqueous humor cell-free DNA is a prognostic biomarker for retinoblastoma ocular survival. Mol Cancer Res. 2020 May 20. Xu L, Polski A, Prabakar RK, Reid MW, Chevez-Barrios P, Jubran R, Kim JW, Kuhn P, Cobrinik D, Hicks J, Berry JL. PMID: 32434859.
      View in: PubMed   Mentions:    Fields:    
    2. Variability in retinoblastoma genome stability is driven by age and not heritability. Genes Chromosomes Cancer. 2020 May 11. Polski A, Xu L, Prabakar RK, Gai X, Kim JW, Shah R, Jubran R, Kuhn P, Cobrinik D, Hicks J, Berry JL. PMID: 32390242.
      View in: PubMed   Mentions:    Fields:    
    3. Corrigendum to "Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. "Alive, with good vision and no comorbidity"" [Prog. Retina Eye Res. 73 (2019) 100764]. Prog Retin Eye Res. 2020 Apr 08; 100857. Munier FL, Beck-Popovic M, Chantada GL, Cobrinik D, Kivelä TT, Lohmann D, Maeder P, Moll AC, Carcaboso AM, Moulin A, Schaiquevich P, Bergin C, Dyson PJ, Houghton S, Puccinelli F, Vial Y, Gaillard MC, Stathopoulos C. PMID: 32278633.
      View in: PubMed   Mentions:    Fields:    
    4. Improved third-generation lentiviral packaging with pLKO.1C vectors. Biotechniques. 2020 Jun; 68(6):349-352. Lee S, Cobrinik D. PMID: 32141762.
      View in: PubMed   Mentions:    Fields:    
    5. Detection of mitochondrial DNA variants at low level heteroplasmy in pediatric CNS and extra-CNS solid tumors with three different enrichment methods. Mitochondrion. 2020 03; 51:97-103. Kaneva K, Merkurjev D, Ostrow D, Ryutov A, Triska P, Stachelek K, Cobrinik D, Biegel JA, Gai X. PMID: 31972374.
      View in: PubMed   Mentions:    Fields:    
    6. Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. "Alive, with good vision and no comorbidity". Prog Retin Eye Res. 2019 11; 73:100764. Munier FL, Beck-Popovic M, Chantada GL, Cobrinik D, Kivelä TT, Lohmann D, Maeder P, Moll AC, Carcaboso AM, Moulin A, Schaiquevich P, Bergin C, Dyson PJ, Houghton S, Puccinelli F, Vial Y, Gaillard MC, Stathopoulos C. PMID: 31173880.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. A novel thyroid hormone receptor isoform, TRß2-46, promotes SKP2 expression and retinoblastoma cell proliferation. J Biol Chem. 2019 02 22; 294(8):2961-2969. Li Z, Qi DL, Singh HP, Zou Y, Shen B, Cobrinik D. PMID: 30643022.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Developmental stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):E9391-E9400. Singh HP, Wang S, Stachelek K, Lee S, Reid MW, Thornton ME, Craft CM, Grubbs BH, Cobrinik D. PMID: 30213853.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. Genomic cfDNA Analysis of Aqueous Humor in Retinoblastoma Predicts Eye Salvage: The Surrogate Tumor Biopsy for Retinoblastoma. Mol Cancer Res. 2018 11; 16(11):1701-1712. Berry JL, Xu L, Kooi I, Murphree AL, Prabakar RK, Reid M, Stachelek K, Le BHA, Welter L, Reiser BJ, Chévez-Barrios P, Jubran R, Lee TC, Kim JW, Kuhn P, Cobrinik D, Hicks J. PMID: 30061186.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    10. Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma-Reply. JAMA Ophthalmol. 2018 05 01; 136(5):598. Berry JL, Cobrinik D, Hicks J. PMID: 29566117.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Potential of Aqueous Humor as a Surrogate Tumor Biopsy for Retinoblastoma. JAMA Ophthalmol. 2017 11 01; 135(11):1221-1230. Berry JL, Xu L, Murphree AL, Krishnan S, Stachelek K, Zolfaghari E, McGovern K, Lee TC, Carlsson A, Kuhn P, Kim JW, Cobrinik D, Hicks J. PMID: 29049475.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    12. SKP2 Activation by Thyroid Hormone Receptor ß2 Bypasses Rb-Dependent Proliferation in Rb-Deficient Cells. Cancer Res. 2017 12 15; 77(24):6838-6850. Xu XL, Li Z, Liu A, Fan X, Hu DN, Qi DL, Chitty DW, Jia R, Qui J, Wang JQ, Sharaf J, Zou J, Weiss R, Huang H, Joseph WJ, Ng L, Rosen R, Shen B, Reid MW, Forrest D, Abramson DH, Singer S, Cobrinik D, Jhanwar SC. PMID: 28972075.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    13. Structural and Functional Characterization of Human Stem-Cell-Derived Retinal Organoids by Live Imaging. Invest Ophthalmol Vis Sci. 2017 07 01; 58(9):3311-3318. Browne AW, Arnesano C, Harutyunyan N, Khuu T, Martinez JC, Pollack HA, Koos DS, Lee TC, Fraser SE, Moats RA, Aparicio JG, Cobrinik D. PMID: 28672397.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    14. MDM2 but not MDM4 promotes retinoblastoma cell proliferation through p53-independent regulation of MYCN translation. Oncogene. 2017 03 30; 36(13):1760-1769. Qi DL, Cobrinik D. PMID: 27748758.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    15. A Rapid and Sensitive Next-Generation Sequencing Method to Detect RB1 Mutations Improves Care for Retinoblastoma Patients and Their Families. J Mol Diagn. 2016 07; 18(4):480-93. Li WL, Buckley J, Sanchez-Lara PA, Maglinte DT, Viduetsky L, Tatarinova TV, Aparicio JG, Kim JW, Au M, Ostrow D, Lee TC, O'Gorman M, Judkins A, Cobrinik D, Triche TJ. PMID: 27155049.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    16. Detection and Intraretinal Localization of an 'Invisible' Retinoblastoma Using Optical Coherence Tomography. Ocul Oncol Pathol. 2016 Apr; 2(3):148-52. Berry JL, Cobrinik D, Kim JW. PMID: 27239455.
      View in: PubMed   Mentions:
    17. Retinoblastoma. Nat Rev Dis Primers. 2015 08 27; 1:15021. Dimaras H, Corson TW, Cobrinik D, White A, Zhao J, Munier FL, Abramson DH, Shields CL, Chantada GL, Njuguna F, Gallie BL. PMID: 27189421.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    18. Retinoblastoma Progression. EBioMedicine. 2015 Jul; 2(7):623-4. Cobrinik D. PMID: 26288828.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    19. Rb suppresses human cone-precursor-derived retinoblastoma tumours. Nature. 2014 Oct 16; 514(7522):385-8. Xu XL, Singh HP, Wang L, Qi DL, Poulos BK, Abramson DH, Jhanwar SC, Cobrinik D. PMID: 25252974.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    20. Recurrent pre-existing and acquired DNA copy number alterations, including focal TERT gains, in neuroblastoma central nervous system metastases. Genes Chromosomes Cancer. 2013 Dec; 52(12):1150-66. Cobrinik D, Ostrovnaya I, Hassimi M, Tickoo SK, Cheung IY, Cheung NK. PMID: 24123354.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    21. Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E)BRAF. Oncogene. 2012 Jan 26; 31(4):446-57. Xing F, Persaud Y, Pratilas CA, Taylor BS, Janakiraman M, She QB, Gallardo H, Liu C, Merghoub T, Hefter B, Dolgalev I, Viale A, Heguy A, De Stanchina E, Cobrinik D, Bollag G, Wolchok J, Houghton A, Solit DB. PMID: 21725359.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimals
    22. Critical role of the Rb family in myoblast survival and fusion. PLoS One. 2011 Mar 10; 6(3):e17682. Ciavarra G, Ho AT, Cobrinik D, Zacksenhaus E. PMID: 21423694.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    23. Tumor-associated retinal astrocytes promote retinoblastoma cell proliferation through production of IGFBP-5. Am J Pathol. 2010 Jul; 177(1):424-35. Xu XL, Lee TC, Offor N, Cheng C, Liu A, Fang Y, Jhanwar SC, Abramson DH, Cobrinik D. PMID: 20508032.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    24. Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice. Nat Genet. 2010 Jan; 42(1):83-8. Wang H, Bauzon F, Ji P, Xu X, Sun D, Locker J, Sellers RS, Nakayama K, Nakayama KI, Cobrinik D, Zhu L. PMID: 19966802.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    25. Retinoblastoma has properties of a cone precursor tumor and depends upon cone-specific MDM2 signaling. Cell. 2009 Jun 12; 137(6):1018-31. Xu XL, Fang Y, Lee TC, Forrest D, Gregory-Evans C, Almeida D, Liu A, Jhanwar SC, Abramson DH, Cobrinik D. PMID: 19524506.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    26. The retinoblastoma protein and its homolog p130 regulate the G1/S transition in pancreatic beta-cells. Diabetes. 2009 Aug; 58(8):1852-62. Harb G, Vasavada RC, Cobrinik D, Stewart AF. PMID: 19509021.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    27. Rb induces a proliferative arrest and curtails Brn-2 expression in retinoblastoma cells. Mol Cancer. 2006 Dec 12; 5:72. Cobrinik D, Francis RO, Abramson DH, Lee TC. PMID: 17163992.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    28. Cell cycle-specific and cell type-specific expression of Rb in the developing human retina. Invest Ophthalmol Vis Sci. 2006 Dec; 47(12):5590-8. Lee TC, Almeida D, Claros N, Abramson DH, Cobrinik D. PMID: 17122153.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    29. Small molecule inhibition of HDM2 leads to p53-mediated cell death in retinoblastoma cells. Arch Ophthalmol. 2006 Sep; 124(9):1269-75. Elison JR, Cobrinik D, Claros N, Abramson DH, Lee TC. PMID: 16966622.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    30. Pocket proteins and cell cycle control. Oncogene. 2005 Apr 18; 24(17):2796-809. Cobrinik D. PMID: 15838516.
      View in: PubMed   Mentions: 217     Fields:    Translation:HumansCells
    31. The cyclin-dependent kinase inhibitor p57(Kip2) mediates proliferative actions of PTHrP in chondrocytes. J Clin Invest. 2004 May; 113(9):1334-43. MacLean HE, Guo J, Knight MC, Zhang P, Cobrinik D, Kronenberg HM. PMID: 15124025.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    32. Regulation of PML-dependent transcriptional repression by pRB and low penetrance pRB mutants. Oncogene. 2002 Aug 15; 21(36):5557-65. Fang W, Mori T, Cobrinik D. PMID: 12165854.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    33. FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest. J Cell Biol. 2002 Aug 19; 158(4):741-50. Laplantine E, Rossi F, Sahni M, Basilico C, Cobrinik D. PMID: 12177046.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    34. p107 and p130 Coordinately regulate proliferation, Cbfa1 expression, and hypertrophic differentiation during endochondral bone development. Dev Biol. 2002 Jul 15; 247(2):271-85. Rossi F, MacLean HE, Yuan W, Francis RO, Semenova E, Lin CS, Kronenberg HM, Cobrinik D. PMID: 12086466.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    35. Rho regulates p21(CIP1), cyclin D1, and checkpoint control in mammary epithelial cells. Oncogene. 2002 Feb 28; 21(10):1590-9. Liberto M, Cobrinik D, Minden A. PMID: 11896588.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    36. Complementary and alternative medicine: the role of the cancer center. J Clin Oncol. 2001 Sep 15; 19(18 Suppl):55S-60S. Antman K, Benson MC, Chabot J, Cobrinik D, Grann VR, Jacobson JS, Joe AK, Katz AE, Kelly K, Neugut AI, Russo D, Tiersten A, Weinstein IB. PMID: 11560974.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    37. Cdk2-dependent phosphorylation and functional inactivation of the pRB-related p130 protein in pRB(-), p16INK4A(+) tumor cells. J Biol Chem. 2000 Sep 29; 275(39):30317-25. Cheng L, Rossi F, Fang W, Mori T, Cobrinik D. PMID: 10906146.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    38. Growth factor-dependent induction of p21(CIP1) by the green tea polyphenol, epigallocatechin gallate. Cancer Lett. 2000 Jun 30; 154(2):151-61. Liberto M, Cobrinik D. PMID: 10806303.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    39. pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev. 1997 Jun 01; 11(11):1447-63. Hurford RK, Cobrinik D, Lee MH, Dyson N. PMID: 9192872.
      View in: PubMed   Mentions: 158     Fields:    Translation:AnimalsCells
    40. Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev. 1996 Jul 01; 10(13):1633-44. Cobrinik D, Lee MH, Hannon G, Mulligan G, Bronson RT, Dyson N, Harlow E, Beach D, Weinberg RA, Jacks T. PMID: 8682294.
      View in: PubMed   Mentions: 146     Fields:    Translation:AnimalsCells
    41. Regulatory interactions among E2Fs and cell cycle control proteins. Curr Top Microbiol Immunol. 1996; 208:31-61. Cobrinik D. PMID: 8575212.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    42. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc Natl Acad Sci U S A. 1995 Mar 14; 92(6):2403-7. Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA. PMID: 7892279.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    43. Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev. 1993 Dec; 7(12A):2392-404. Cobrinik D, Whyte P, Peeper DS, Jacks T, Weinberg RA. PMID: 8253385.
      View in: PubMed   Mentions: 122     Fields:    Translation:AnimalsCells
    44. The retinoblastoma protein and the regulation of cell cycling. Trends Biochem Sci. 1992 Aug; 17(8):312-5. Cobrinik D, Dowdy SF, Hinds PW, Mittnacht S, Weinberg RA. PMID: 1412705.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    45. Interaction between retroviral U5 RNA and the T psi C loop of the tRNA(Trp) primer is required for efficient initiation of reverse transcription. J Virol. 1992 Apr; 66(4):2464-72. Aiyar A, Cobrinik D, Ge Z, Kung HJ, Leis J. PMID: 1548772.
      View in: PubMed   Mentions: 79     Fields:    Translation:Cells
    46. Overlapping retrovirus U5 sequence elements are required for efficient integration and initiation of reverse transcription. J Virol. 1991 Jul; 65(7):3864-72. Cobrinik D, Aiyar A, Ge Z, Katzman M, Huang H, Leis J. PMID: 1710292.
      View in: PubMed   Mentions: 48     Fields:    Translation:Cells
    47. A retroviral RNA secondary structure required for efficient initiation of reverse transcription. J Virol. 1988 Oct; 62(10):3622-30. Cobrinik D, Soskey L, Leis J. PMID: 2458484.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    48. Properties of avian sarcoma-leukosis virus pp32-related pol-endonucleases produced in Escherichia coli. J Virol. 1988 Jul; 62(7):2358-65. Terry R, Soltis DA, Katzman M, Cobrinik D, Leis J, Skalka AM. PMID: 2836618.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    49. Avian sarcoma and leukosis virus pol-endonuclease recognition of the tandem long terminal repeat junction: minimum site required for cleavage is also required for viral growth. J Virol. 1987 Jun; 61(6):1999-2008. Cobrinik D, Katz R, Terry R, Skalka AM, Leis J. PMID: 3033327.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    50. Circles with two tandem long terminal repeats are specifically cleaved by pol gene-associated endonuclease from avian sarcoma and leukosis viruses: nucleotide sequences required for site-specific cleavage. J Virol. 1985 Nov; 56(2):589-99. Duyk G, Longiaru M, Cobrinik D, Kowal R, deHaseth P, Skalka AM, Leis J. PMID: 2414465.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
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