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Aaron Nagiel, MD, PhD

TitleAssistant Professor of Ophthalmology
InstitutionUniversity of Southern California
DepartmentPediatrics
Address4640 West Sunset Boulevard
Off Campus
Los Angeles CA 90027
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    Collapse Biography 
    Collapse Education and Training
    Weill Cornell Medical CollegeMD
    The Rockefeller UniversityPhD
    Memorial Sloan-Kettering Cancer CenterInternship
    UCLA Jules Stein Eye InstituteResidencyOphthalmology
    UCLA Jules Stein Eye InstituteFellowshipVitreoretinal
    Collapse Awards and Honors
    Harvard University2001Detur Prize
    2001  - 2003John Harvard Scholarship
    2006Finalist, Paul and Daisy Soros Fellowship for New Americans
    The Rockefeller University2010Sumi Koide Travel Fellowship
    Jules Stein Eye Institute2013Robert E. Christensen Research Award
    2014ARVO National Eye Institute Travel Grant
    Jules Stein Eye Institute2014Excellence in Research Award
    Jules Stein Eye Institute2014  - 2015Pepose-Saltzman Young Investigator ARVO Award
    2014Heed Foundation Residents Retreat Participant
    2015  - 2016Heed Ophthalmic Foundation Fellowship
    Jules Stein Eye Institute2016Excellence in Research Award
    2016  - 2017Ronald G. Michels Fellowship Foundation Award
    2016  - 2019Allergan FIRST (Fostering Innovative Retina Stars of Tomorrow) Fellowship

    Collapse Overview 
    Collapse Overview
    The development and maintenance of specific synaptic connections between retinal neurons is critical to its function. However, our understanding of neural circuit formation in the human retina remains limited. Within the last 10 years it has become possible to grow 3-dimensional, multi-layered retinal organoids derived from human stem cells. This advance permits the study of human retinal development and the establishment of synaptic connectivity. Our goal is to elucidate mechanisms underlying synapse formation and specificity in the first synapse of the human visual system. Access to patient-derived organoids allows us to understand this process in the disease state and following novel treatment paradigms such as gene therapy and cell-based therapy. We utilize a variety of techniques including live fluorescent imaging, electrophysiology, and gene editing in stem cell-derived human retinal organoids. The long-term goal of this work is to understand how synaptic connections are established and maintained in the human nervous system.

    https://www.chla.org/research/nagiel-laboratory


    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yeo DCM, Nagiel A, Yang U, Lee TC, Wong SC. Endoscopy for Pediatric Retinal Disease. Asia Pac J Ophthalmol (Phila). 2018 May 30. PMID: 29862672.
      View in: PubMed
    2. Chen X, Sanfilippo CJ, Nagiel A, Hosseini H, Mitchell D, McCannel CA, Schwartz SD, McCannel TA. EARLY DETECTION OF RETINAL HEMANGIOBLASTOMAS IN VON HIPPEL-LINDAU DISEASE USING ULTRA-WIDEFIELD FLUORESCEIN ANGIOGRAPHY. Retina. 2018 Apr; 38(4):748-754. PMID: 28368975.
      View in: PubMed
    3. Nagiel A. Gene therapy for RPE65-mediated retinal dystrophies. Surv Ophthalmol. 2018 May - Jun; 63(3):445-446. PMID: 29248533.
      View in: PubMed
    4. Phasukkijwatana N, Freund KB, Dolz-Marco R, Al-Sheikh M, Keane PA, Egan CA, Randhawa S, Stewart JM, Liu Q, Hunyor AP, Kreiger A, Nagiel A, Lalane R, Rahimi M, Lee WK, Jampol LM, Sarraf D. PERIPAPILLARY PACHYCHOROID SYNDROME. Retina. 2017 Nov 10. PMID: 29135799.
      View in: PubMed
    5. Nagiel A, Lalane RA, Jen JC, Kreiger AE. SUPERFICIAL AND DEEP CAPILLARY ISCHEMIA AS A PRESENTING SIGN OF RETINAL VASCULOPATHY WITH CEREBRAL LEUKOENCEPHALOPATHY AND SYSTEMIC MANIFESTATIONS. Retin Cases Brief Rep. 2017 Oct 12. PMID: 29028736.
      View in: PubMed
    6. Nagiel A, McCannel CA, Moreno C, McCannel TA. VITRECTOMY-ASSISTED BIOPSY FOR MOLECULAR PROGNOSTICATION OF CHOROIDAL MELANOMA 2 MM OR LESS IN THICKNESS WITH A 27-GAUGE CUTTER. Retina. 2017 Jul; 37(7):1377-1382. PMID: 28486310.
      View in: PubMed
    7. Nemiroff J, Phasukkijwatana N, Vaclavik V, Nagiel A, Holz ER, Sarraf D. THE SPECTRUM OF AMALRIC TRIANGULAR CHOROIDAL INFARCTION. Retin Cases Brief Rep. 2017 Winter; 11 Suppl 1:S113-S120. PMID: 27780182.
      View in: PubMed
    8. Nagiel A, Rootman DB, McCannel TA. PARANEOPLASTIC VITELLIFORM MACULOPATHY IN THE SETTING OF CHOROIDAL MELANOMA: EVOLUTION OVER ONE YEAR. Retin Cases Brief Rep. 2017 Winter; 11 Suppl 1:S7-S10. PMID: 27533643.
      View in: PubMed
    9. Chang MY, Shin A, Park J, Nagiel A, Lalane RA, Schwartz SD, Demer JL. Deformation of Optic Nerve Head and Peripapillary Tissues by Horizontal Duction. Am J Ophthalmol. 2017 Feb; 174:85-94. PMID: 27751810.
      View in: PubMed
    10. Nagiel A, Lalane RA, Sadda SR, Schwartz SD. ULTRA-WIDEFIELD FUNDUS IMAGING: A Review of Clinical Applications and Future Trends. Retina. 2016 Apr; 36(4):660-78. PMID: 27014860.
      View in: PubMed
    11. Schwartz SD, Tan G, Hosseini H, Nagiel A. Subretinal Transplantation of Embryonic Stem Cell-Derived Retinal Pigment Epithelium for the Treatment of Macular Degeneration: An Assessment at 4 Years. Invest Ophthalmol Vis Sci. 2016 Apr 01; 57(5):ORSFc1-9. PMID: 27116660.
      View in: PubMed
    12. Idiga J, Rootman DB, Nagiel A, Goldberg RA. Isolated Zygomycetes Endophthalmitis: A Case Report. Ophthal Plast Reconstr Surg. 2015 Nov-Dec; 31(6):e145-7. PMID: 24833448.
      View in: PubMed
    13. Nagiel A, Sadda SR, Sarraf D. A Promising Future for Optical Coherence Tomography Angiography. JAMA Ophthalmol. 2015 Jun; 133(6):629-30. PMID: 25856444.
      View in: PubMed
    14. Nagiel A, Sarraf D, Sadda SR, Spaide RF, Jung JJ, Bhavsar KV, Ameri H, Querques G, Freund KB. Type 3 neovascularization: evolution, association with pigment epithelial detachment, and treatment response as revealed by spectral domain optical coherence tomography. Retina. 2015 Apr; 35(4):638-47. PMID: 25650713.
      View in: PubMed
    15. Nagiel A, Sadda SR, Schwartz SD, Sarraf D. RESOLUTION OF A GIANT PIGMENT EPITHELIAL DETACHMENT WITH HALF-DOSE AFLIBERCEPT. Retin Cases Brief Rep. 2015; 9(4):269-72. PMID: 26237136.
      View in: PubMed
    16. Nagiel A, Freund KB, Spaide RF, Munch IC, Larsen M, Sarraf D. Mechanism of retinal pigment epithelium tear formation following intravitreal anti-vascular endothelial growth factor therapy revealed by spectral-domain optical coherence tomography. Am J Ophthalmol. 2013 Nov; 156(5):981-988.e2. PMID: 23972309.
      View in: PubMed
    17. Nagiel A, Espiritu MJ, Wong RK, Lee TC, Lauer AK, Chiang MF, Chan RV. Retinopathy of prematurity residency training. Ophthalmology. 2012 Dec; 119(12):2644-5.e1-2. PMID: 23207022; PMCID: PMC3921178.
    18. Francis JH, Gobin YP, Nagiel A, Dunkel IJ, Kucine N, Marr BP, Brodie SE, Abramson DH. Thrombophilia in patients with retinoblastoma receiving ophthalmic artery chemosurgery. Arch Ophthalmol. 2012 Dec; 130(12):1605-8. PMID: 23229706.
      View in: PubMed
    19. Nagiel A, Patel SH, Andor-Ardó D, Hudspeth AJ. Activity-independent specification of synaptic targets in the posterior lateral line of the larval zebrafish. Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21948-53. PMID: 19996172.
      View in: PubMed
    20. Gleason MR, Nagiel A, Jamet S, Vologodskaia M, López-Schier H, Hudspeth AJ. The transmembrane inner ear (Tmie) protein is essential for normal hearing and balance in the zebrafish. Proc Natl Acad Sci U S A. 2009 Dec 15; 106(50):21347-52. PMID: 19934034; PMCID: PMC2781060.
    21. Nagiel A, Andor-Ardó D, Hudspeth AJ. Specificity of afferent synapses onto plane-polarized hair cells in the posterior lateral line of the zebrafish. J Neurosci. 2008 Aug 20; 28(34):8442-53. PMID: 18716202; PMCID: PMC2665254.
    22. Gonzalez E, Nagiel A, Lin AJ, Golan DE, Michel T. Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells. J Biol Chem. 2004 Sep 24; 279(39):40659-69. PMID: 15292187.
      View in: PubMed