Aaron Nagiel, MD, PhD

Title(s)Assistant Professor of Ophthalmology
Address4640 West Sunset Blvd
Off Campus
Los Angeles CA 90027
ORCID ORCID Icon0000-0001-7275-6980 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Weill Cornell Medical CollegeMD
    The Rockefeller UniversityPhD
    Memorial Sloan-Kettering Cancer CenterInternship
    UCLA Jules Stein Eye InstituteResidencyOphthalmology
    UCLA Jules Stein Eye InstituteFellowshipVitreoretinal
    Collapse Awards and Honors
    Harvard University2001Detur Prize
    2001  - 2003John Harvard Scholarship
    2006Finalist, Paul and Daisy Soros Fellowship for New Americans
    The Rockefeller University2010Sumi Koide Travel Fellowship
    Jules Stein Eye Institute2013Robert E. Christensen Research Award
    2014ARVO National Eye Institute Travel Grant
    Jules Stein Eye Institute2014Excellence in Research Award
    Jules Stein Eye Institute2014  - 2015Pepose-Saltzman Young Investigator ARVO Award
    2014Heed Foundation Residents Retreat Participant
    2015  - 2016Heed Ophthalmic Foundation Fellowship
    Jules Stein Eye Institute2016Excellence in Research Award
    2016  - 2017Ronald G. Michels Fellowship Foundation Award
    2016  - 2019Allergan FIRST (Fostering Innovative Retina Stars of Tomorrow) Fellowship
    Michels Fellowship Foundation2016  - 2017Ronald G. Michels Fellowship
    Donald E. and Delia B. Baxter Foundation2019  - 2020Baxter Foundation Fellowship
    Research to Prevent Blindness2021  - 2023RPB Career Development Award

    Collapse Overview 
    Collapse Overview
    The development and maintenance of specific synaptic connections between retinal neurons is critical to its function. However, our understanding of neural circuit formation in the human retina remains limited. Within the last 10 years it has become possible to grow 3-dimensional, multi-layered retinal organoids derived from human stem cells. This advance permits the study of human retinal development and the establishment of synaptic connectivity. Our goal is to elucidate mechanisms underlying synapse formation and specificity in the first synapse of the human visual system. Access to patient-derived organoids allows us to understand this process in the disease state and following novel treatment paradigms such as gene therapy and cell-based therapy. We utilize a variety of techniques including live fluorescent imaging, electrophysiology, and gene editing in stem cell-derived human retinal organoids. The long-term goal of this work is to understand how synaptic connections are established and maintained in the human nervous system.

    Visit our lab website: nagiellab.org

    Collapse ORNG Applications 
    Collapse Featured Publications

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Recessive ciliopathy mutations in primary endocardial fibroelastosis: a rare neonatal cardiomyopathy in a case of Alstrom syndrome. J Mol Med (Berl). 2021 Aug 13. Zhao Y, Wang LK, Eskin A, Kang X, Fajardo VM, Mehta Z, Pineles S, Schmidt RJ, Nagiel A, Satou G, Garg M, Federman M, Reardon LC, Lee SL, Biniwale R, Grody WW, Halnon N, Khanlou N, Quintero-Rivera F, Alejos JC, Nakano A, Fishbein GA, Van Arsdell GS, Nelson SF, Touma M. PMID: 34387706.
      View in: PubMed   Mentions:    Fields:    
    2. Characterization of the Spectrum of Ophthalmic Changes in Patients With Alagille Syndrome. Invest Ophthalmol Vis Sci. 2021 Jun 01; 62(7):27. da Palma MM, Igelman AD, Ku C, Burr A, You JY, Place EM, Wang NK, Oh JK, Branham KE, Zhang X, Ahn J, Gorin MB, Lam BL, Ronquillo CC, Bernstein PS, Nagiel A, Huckfeldt R, Cabrera MT, Kelly JP, Bakall B, Iannaccone A, Hufnagel RB, Zein WM, Koenekoop RK, Birch DG, Yang P, Fahim AT, Pennesi ME. PMID: 34185059.
      View in: PubMed   Mentions:    Fields:    
    3. Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues. Nat Commun. 2021 05 25; 12(1):3100. Kastan N, Gnedeva K, Alisch T, Petelski AA, Huggins DJ, Chiaravalli J, Aharanov A, Shakked A, Tzahor E, Nagiel A, Segil N, Hudspeth AJ. PMID: 34035288.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Perifoveal Chorioretinal Atrophy after Subretinal Voretigene Neparvovec-rzyl for RPE65-Mediated Leber Congenital Amaurosis. Ophthalmol Retina. 2021 Apr 08. Gange WS, Sisk RA, Besirli CG, Lee TC, Havunjian M, Schwartz H, Borchert M, Sengillo JD, Mendoza C, Berrocal AM, Nagiel A. PMID: 33838313.
      View in: PubMed   Mentions:    Fields:    
    5. Identification of candidate genes and pathways in retinopathy of prematurity by whole exome sequencing of preterm infants enriched in phenotypic extremes. Sci Rep. 2021 Mar 02; 11(1):4966. Kim SJ, Sonmez K, Swan R, Campbell JP, Ostmo S, Chan RVP, Nagiel A, Drenser KA, Berrocal AM, Horowitz JD, Li X, Chen YI, Taylor KD, Simmons C, Rotter JI, Chiang MF, Imaging and Informatics in Retinopathy of Prematurity (i-ROP) Research Consortium . PMID: 33654115.
      View in: PubMed   Mentions:    Fields:    
    6. Endoscopic vitreoretinal surgery: Review of current applications and future trends. Surv Ophthalmol. 2021 Mar-Apr; 66(2):198-212. Lai FHP, Wong EWN, Lam WC, Lee TC, Wong SC, Nagiel A, Lam RF. PMID: 33278403.
      View in: PubMed   Mentions:    Fields:    
    7. Traumatic Retinal Detachment in Patients with Self-Injurious Behavior: An International Multicenter Study. Ophthalmol Retina. 2021 Aug; 5(8):805-814. Rossin EJ, Tsui I, Wong SC, Hou KK, Prakhunhungsit S, Blair MP, Shapiro MJ, Leishman L, Nagiel A, Lifton JA, Quiram P, Ringeisen AL, Henderson RH, Arruti N, Buzzacco DM, Kusaka S, Ferrone PJ, Belin PJ, Chang E, Hubschman JP, Murray TG, Leung EH, Wu WC, Olsen KR, Harper CA, Rahmani S, Goldstein J, Lee T, Nudleman E, Cernichiaro-Espinosa LA, Chhablani J, Berrocal AM, Yonekawa Y. PMID: 33238225.
      View in: PubMed   Mentions:    Fields:    
    8. Genotype Phenotype Correlation and Variability in Microcephaly Associated With Chorioretinopathy or Familial Exudative Vitreoretinopathy. Invest Ophthalmol Vis Sci. 2020 11 02; 61(13):2. Shurygina MF, Simonett JM, Parker MA, Mitchell A, Grigorian F, Lifton J, Nagiel A, Shpak AA, Dadali EL, Mishina IA, Weleber RG, Yang P, Pennesi ME. PMID: 33137195.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. VISUAL AND ANATOMIC OUTCOMES OF PEDIATRIC ENDOSCOPIC VITRECTOMY IN 326 CASES. Retina. 2020 Nov; 40(11):2083-2090. Nagiel A, Yang U, Reid MW, Anulao KJ, Say EAT, Wong SC, Lee TC. PMID: 32091489.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. Vitreous Hemorrhage in Type 3 Gaucher Disease: An Angiographic and Pathologic Analysis. Retin Cases Brief Rep. 2020 Sep 28. Hua HU, Haghighi A, Shillingford N, Lee TC, Nagiel A. PMID: 33017378.
      View in: PubMed   Mentions:    Fields:    
    11. Diagnostic and Therapeutic Challenges. Retina. 2020 Aug; 40(8):1641-1643. Han YS, Mehta AM, Lee TC, Nagiel A, Pulido JS. PMID: 31365518.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Precision Therapy for Inherited Retinal Disease: At the Forefront of Genomic Medicine. Clin Lab Med. 2020 06; 40(2):189-204. Koulisis N, Nagiel A. PMID: 32439068.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    13. Bilateral retinal detachment after chimeric antigen receptor T-cell therapy. Blood Adv. 2020 05 26; 4(10):2158-2162. Denton CC, Gange WS, Abdel-Azim H, Jodele S, Kapoor N, Oberley MJ, Wong K, Kim J, Vercio A, Moghaddampour P, Chalam KV, Sierpina D, Gardner RA, Pulsipher MA, Jensen MC, Nagiel A. PMID: 32428218.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. Focal Scleral Nodule: A New Name for Solitary Idiopathic Choroiditis and Unifocal Helioid Choroiditis. Ophthalmology. 2020 11; 127(11):1567-1577. Fung AT, Waldstein SM, Gal-Or O, Pellegrini M, Preziosa C, Shields JA, Welch RJ, Dolz-Marco R, Sarraf D, Nagiel A, Lalane R, Jung JJ, Ghazi NG, Ramtohul P, Arnold JJ, Sakurada Y, Choudhry N, Balaratnasingam C, Freund KB, Shields CL. PMID: 32507351.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    15. Voretigene neparvovec-rzyl for treatment of RPE65-mediated inherited retinal diseases: a model for ocular gene therapy development. Expert Opin Biol Ther. 2020 06; 20(6):565-578. Ciulla TA, Hussain RM, Berrocal AM, Nagiel A. PMID: 32149547.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    16. Surgical Techniques for the Subretinal Delivery of Pediatric Gene Therapy. Ophthalmol Retina. 2020 06; 4(6):644-645. Fan KC, Yannuzzi NA, Patel NA, Negron CI, Sisk RA, Nagiel A, Berrocal AM. PMID: 32387052.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Late-Onset Retinal Findings and Complications in Untreated Retinopathy of Prematurity. Ophthalmol Retina. 2020 06; 4(6):602-612. Hamad AE, Moinuddin O, Blair MP, Schechet SA, Shapiro MJ, Quiram PA, Mammo DA, Berrocal AM, Prakhunhungsit S, Cernichiaro-Espinosa LA, Mukai S, Yonekawa Y, Ung C, Holz ER, Harper CA, Young RC, Besirli CG, Nagiel A, Lee TC, Gupta MP, Walsh MK, Khawly JA, Campbell JP, Kychenthal A, Nudleman ED, Robinson JE, Hartnett ME, Calvo CM, Chang EY. PMID: 32059986.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    18. Utility of In Vitro Mutagenesis of RPE65 Protein for Verification of Mutational Pathogenicity Before Gene Therapy. JAMA Ophthalmol. 2019 12 01; 137(12):1381-1388. Yang U, Gentleman S, Gai X, Gorin MB, Borchert MS, Lee TC, Villanueva A, Koenekoop R, Maguire AM, Bennett J, Redmond TM, Nagiel A. PMID: 31580392.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    19. Ocular Trauma From Toy Guns With Foam Projectiles in 4 Children. Clin Pediatr (Phila). 2020 01; 59(1):92-94. Yang U, Greer C, Kim J, Nagiel A. PMID: 31658826.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. Retinal stem cell transplantation: Balancing safety and potential. Prog Retin Eye Res. 2020 03; 75:100779. Singh MS, Park SS, Albini TA, Canto-Soler MV, Klassen H, MacLaren RE, Takahashi M, Nagiel A, Schwartz SD, Bharti K. PMID: 31494256.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    21. Correspondence. Retina. 2019 01; 39(1):e4. Nagiel A. PMID: 30418390.
      View in: PubMed   Mentions:    Fields:    
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. PERIPAPILLARY PACHYCHOROID SYNDROME. Retina. 2018 09; 38(9):1652-1667. Phasukkijwatana N, Freund KB, Dolz-Marco R, Al-Sheikh M, Keane PA, Egan CA, Randhawa S, Stewart JM, Liu Q, Hunyor AP, Kreiger A, Nagiel A, Lalane R, Rahimi M, Lee WK, Jampol LM, Sarraf D. PMID: 29135799.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    24. Practice Patterns of Endophthalmitis Treatment: An International Survey of Retina Specialists. Ophthalmol Retina. 2018 09; 2(9):979-980. Xu D, Nagiel A, Rahimy E, McCannel CA. PMID: 31047231.
      View in: PubMed   Mentions:    Fields:    
    25. Endoscopy for Pediatric Retinal Disease. Asia Pac J Ophthalmol (Phila). 2018 May-Jun; 7(3):200-207. Yeo DCM, Nagiel A, Yang U, Lee TC, Wong SC. PMID: 29862672.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    26. EARLY DETECTION OF RETINAL HEMANGIOBLASTOMAS IN VON HIPPEL-LINDAU DISEASE USING ULTRA-WIDEFIELD FLUORESCEIN ANGIOGRAPHY. Retina. 2018 Apr; 38(4):748-754. Chen X, Sanfilippo CJ, Nagiel A, Hosseini H, Mitchell D, McCannel CA, Schwartz SD, McCannel TA. PMID: 28368975.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    27. Gene therapy for RPE65-mediated retinal dystrophies. Surv Ophthalmol. 2018 May - Jun; 63(3):445-446. Nagiel A. PMID: 29248533.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    29. THE SPECTRUM OF AMALRIC TRIANGULAR CHOROIDAL INFARCTION. Retin Cases Brief Rep. 2017 Winter; 11 Suppl 1:S113-S120. Nemiroff J, Phasukkijwatana N, Vaclavik V, Nagiel A, Holz ER, Sarraf D. PMID: 27780182.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    31. Deformation of Optic Nerve Head and Peripapillary Tissues by Horizontal Duction. Am J Ophthalmol. 2017 Feb; 174:85-94. Chang MY, Shin A, Park J, Nagiel A, Lalane RA, Schwartz SD, Demer JL. PMID: 27751810.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    32. ULTRA-WIDEFIELD FUNDUS IMAGING: A Review of Clinical Applications and Future Trends. Retina. 2016 Apr; 36(4):660-78. Nagiel A, Lalane RA, Sadda SR, Schwartz SD. PMID: 27014860.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    33. Subretinal Transplantation of Embryonic Stem Cell-Derived Retinal Pigment Epithelium for the Treatment of Macular Degeneration: An Assessment at 4 Years. Invest Ophthalmol Vis Sci. 2016 Apr 01; 57(5):ORSFc1-9. Schwartz SD, Tan G, Hosseini H, Nagiel A. PMID: 27116660.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    34. Isolated Zygomycetes Endophthalmitis: A Case Report. Ophthalmic Plast Reconstr Surg. 2015 Nov-Dec; 31(6):e145-7. Idiga J, Rootman DB, Nagiel A, Goldberg RA. PMID: 24833448.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    35. A Promising Future for Optical Coherence Tomography Angiography. JAMA Ophthalmol. 2015 Jun; 133(6):629-30. Nagiel A, Sadda SR, Sarraf D. PMID: 25856444.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    36. Type 3 neovascularization: evolution, association with pigment epithelial detachment, and treatment response as revealed by spectral domain optical coherence tomography. Retina. 2015 Apr; 35(4):638-47. Nagiel A, Sarraf D, Sadda SR, Spaide RF, Jung JJ, Bhavsar KV, Ameri H, Querques G, Freund KB. PMID: 25650713.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    37. RESOLUTION OF A GIANT PIGMENT EPITHELIAL DETACHMENT WITH HALF-DOSE AFLIBERCEPT. Retin Cases Brief Rep. 2015; 9(4):269-72. Nagiel A, Sadda SR, Schwartz SD, Sarraf D. PMID: 26237136.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    38. Mechanism of retinal pigment epithelium tear formation following intravitreal anti-vascular endothelial growth factor therapy revealed by spectral-domain optical coherence tomography. Am J Ophthalmol. 2013 Nov; 156(5):981-988.e2. Nagiel A, Freund KB, Spaide RF, Munch IC, Larsen M, Sarraf D. PMID: 23972309.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    39. Thrombophilia in patients with retinoblastoma receiving ophthalmic artery chemosurgery. Arch Ophthalmol. 2012 Dec; 130(12):1605-8. Francis JH, Gobin YP, Nagiel A, Dunkel IJ, Kucine N, Marr BP, Brodie SE, Abramson DH. PMID: 23229706.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    40. Retinopathy of prematurity residency training. Ophthalmology. 2012 Dec; 119(12):2644-5.e1-2. Nagiel A, Espiritu MJ, Wong RK, Lee TC, Lauer AK, Chiang MF, Chan RV. PMID: 23207022.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    41. Activity-independent specification of synaptic targets in the posterior lateral line of the larval zebrafish. Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21948-53. Nagiel A, Patel SH, Andor-Ardó D, Hudspeth AJ. PMID: 19996172.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    42. The transmembrane inner ear (Tmie) protein is essential for normal hearing and balance in the zebrafish. Proc Natl Acad Sci U S A. 2009 Dec 15; 106(50):21347-52. Gleason MR, Nagiel A, Jamet S, Vologodskaia M, López-Schier H, Hudspeth AJ. PMID: 19934034.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    43. Specificity of afferent synapses onto plane-polarized hair cells in the posterior lateral line of the zebrafish. J Neurosci. 2008 Aug 20; 28(34):8442-53. Nagiel A, Andor-Ardó D, Hudspeth AJ. PMID: 18716202.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    44. Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells. J Biol Chem. 2004 Sep 24; 279(39):40659-69. Gonzalez E, Nagiel A, Lin AJ, Golan DE, Michel T. PMID: 15292187.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
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