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Aaron Nagiel, MD, PhD

Title(s)Assistant Professor of Ophthalmology
Address4640 West Sunset Boulevard
Off Campus
Los Angeles CA 90027
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    Collapse Biography 
    Collapse Education and Training
    Weill Cornell Medical CollegeMD
    The Rockefeller UniversityPhD
    Memorial Sloan-Kettering Cancer CenterInternship
    UCLA Jules Stein Eye InstituteResidencyOphthalmology
    UCLA Jules Stein Eye InstituteFellowshipVitreoretinal
    Collapse Awards and Honors
    Harvard University2001Detur Prize
    2001  - 2003John Harvard Scholarship
    2006Finalist, Paul and Daisy Soros Fellowship for New Americans
    The Rockefeller University2010Sumi Koide Travel Fellowship
    Jules Stein Eye Institute2013Robert E. Christensen Research Award
    2014ARVO National Eye Institute Travel Grant
    Jules Stein Eye Institute2014Excellence in Research Award
    Jules Stein Eye Institute2014  - 2015Pepose-Saltzman Young Investigator ARVO Award
    2014Heed Foundation Residents Retreat Participant
    2015  - 2016Heed Ophthalmic Foundation Fellowship
    Jules Stein Eye Institute2016Excellence in Research Award
    2016  - 2017Ronald G. Michels Fellowship Foundation Award
    2016  - 2019Allergan FIRST (Fostering Innovative Retina Stars of Tomorrow) Fellowship

    Collapse Overview 
    Collapse Overview
    The development and maintenance of specific synaptic connections between retinal neurons is critical to its function. However, our understanding of neural circuit formation in the human retina remains limited. Within the last 10 years it has become possible to grow 3-dimensional, multi-layered retinal organoids derived from human stem cells. This advance permits the study of human retinal development and the establishment of synaptic connectivity. Our goal is to elucidate mechanisms underlying synapse formation and specificity in the first synapse of the human visual system. Access to patient-derived organoids allows us to understand this process in the disease state and following novel treatment paradigms such as gene therapy and cell-based therapy. We utilize a variety of techniques including live fluorescent imaging, electrophysiology, and gene editing in stem cell-derived human retinal organoids. The long-term goal of this work is to understand how synaptic connections are established and maintained in the human nervous system.

    https://www.chla.org/research/nagiel-laboratory

    Collapse ORNG Applications 
    Collapse Featured Publications
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Precision Therapy for Inherited Retinal Disease: At the Forefront of Genomic Medicine. Clin Lab Med. 2020 Jun; 40(2):189-204. Koulisis N, Nagiel A. PMID: 32439068.
      View in: PubMed   Mentions:    Fields:    
    2. Bilateral retinal detachment after chimeric antigen receptor T-cell therapy. Blood Adv. 2020 May 26; 4(10):2158-2162. Denton CC, Gange WS, Abdel-Azim H, Jodele S, Kapoor N, Oberley MJ, Wong K, Kim J, Vercio A, Moghaddampour P, Chalam KV, Sierpina D, Gardner RA, Pulsipher MA, Jensen MC, Nagiel A. PMID: 32428218.
      View in: PubMed   Mentions:    Fields:    
    3. Focal Scleral Nodule: A New Name for Solitary Idiopathic Choroiditis and Unifocal Helioid Choroiditis. Ophthalmology. 2020 Apr 22. Fung AT, Waldstein SM, Gal-Or O, Pellegrini M, Preziosa C, Shields JA, Welch RJ, Dolz-Marco R, Sarraf D, Nagiel A, Lalane R, Jung JJ, Ghazi NG, Ramtohul P, Arnold JJ, Sakurada Y, Choudhry N, Balaratnasingam C, Freund KB, Shields CL. PMID: 32507351.
      View in: PubMed   Mentions:    Fields:    
    4. Voretigene neparvovec-rzyl for treatment of RPE65-mediated inherited retinal diseases: a model for ocular gene therapy development. Expert Opin Biol Ther. 2020 Jun; 20(6):565-578. Ciulla TA, Hussain RM, Berrocal AM, Nagiel A. PMID: 32149547.
      View in: PubMed   Mentions:    Fields:    
    5. VISUAL AND ANATOMIC OUTCOMES OF PEDIATRIC ENDOSCOPIC VITRECTOMY IN 326 CASES. Retina. 2020 Feb 19. Nagiel A, Yang U, Reid MW, Anulao KJ, Say EAT, Wong SC, Lee TC. PMID: 32091489.
      View in: PubMed   Mentions:    Fields:    
    6. Surgical Techniques for the Subretinal Delivery of Pediatric Gene Therapy. Ophthalmol Retina. 2020 Feb 05. Fan KC, Yannuzzi NA, Patel NA, Negron CI, Sisk RA, Nagiel A, Berrocal AM. PMID: 32387052.
      View in: PubMed   Mentions:    Fields:    
    7. Late-Onset Retinal Findings and Complications in Untreated Retinopathy of Prematurity. Ophthalmol Retina. 2020 06; 4(6):602-612. Hamad AE, Moinuddin O, Blair MP, Schechet SA, Shapiro MJ, Quiram PA, Mammo DA, Berrocal AM, Prakhunhungsit S, Cernichiaro-Espinosa LA, Mukai S, Yonekawa Y, Ung C, Holz ER, Harper CA, Young RC, Besirli CG, Nagiel A, Lee TC, Gupta MP, Walsh MK, Khawly JA, Campbell JP, Kychenthal A, Nudleman ED, Robinson JE, Hartnett ME, Calvo CM, Chang EY. PMID: 32059986.
      View in: PubMed   Mentions:    Fields:    
    8. Ocular Trauma From Toy Guns With Foam Projectiles in 4 Children. Clin Pediatr (Phila). 2020 Jan; 59(1):92-94. Yang U, Greer C, Kim J, Nagiel A. PMID: 31658826.
      View in: PubMed   Mentions:    Fields:    
    9. Utility of In Vitro Mutagenesis of RPE65 Protein for Verification of Mutational Pathogenicity Before Gene Therapy. JAMA Ophthalmol. 2019 Oct 03; 1-9. Yang U, Gentleman S, Gai X, Gorin MB, Borchert MS, Lee TC, Villanueva A, Koenekoop R, Maguire AM, Bennett J, Redmond TM, Nagiel A. PMID: 31580392.
      View in: PubMed   Mentions:    Fields:    
    10. Retinal stem cell transplantation: Balancing safety and potential. Prog Retin Eye Res. 2020 03; 75:100779. Singh MS, Park SS, Albini TA, Canto-Soler MV, Klassen H, MacLaren RE, Takahashi M, Nagiel A, Schwartz SD, Bharti K. PMID: 31494256.
      View in: PubMed   Mentions: 2     Fields:    
    11. Diagnostic and Therapeutic Challenges. Retina. 2019 Jul 30. Han YS, Mehta AM, Lee TC, Nagiel A, Pulido JS. PMID: 31365518.
      View in: PubMed   Mentions:    Fields:    
    12. Correspondence. Retina. 2019 01; 39(1):e4. Nagiel A. PMID: 30418390.
      View in: PubMed   Mentions:    Fields:    
    13. SUPERFICIAL AND DEEP CAPILLARY ISCHEMIA AS A PRESENTING SIGN OF RETINAL VASCULOPATHY WITH CEREBRAL LEUKOENCEPHALOPATHY AND SYSTEMIC MANIFESTATIONS. Retin Cases Brief Rep. 2018 Fall; 12 Suppl 1:S87-S91. Nagiel A, Lalane RA, Jen JC, Kreiger AE. PMID: 29028736.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. PERIPAPILLARY PACHYCHOROID SYNDROME. Retina. 2018 09; 38(9):1652-1667. Phasukkijwatana N, Freund KB, Dolz-Marco R, Al-Sheikh M, Keane PA, Egan CA, Randhawa S, Stewart JM, Liu Q, Hunyor AP, Kreiger A, Nagiel A, Lalane R, Rahimi M, Lee WK, Jampol LM, Sarraf D. PMID: 29135799.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    15. Practice Patterns of Endophthalmitis Treatment: An International Survey of Retina Specialists. Ophthalmol Retina. 2018 09; 2(9):979-980. Xu D, Nagiel A, Rahimy E, McCannel CA. PMID: 31047231.
      View in: PubMed   Mentions:    Fields:    
    16. Endoscopy for Pediatric Retinal Disease. Asia Pac J Ophthalmol (Phila). 2018 May-Jun; 7(3):200-207. Yeo DCM, Nagiel A, Yang U, Lee TC, Wong SC. PMID: 29862672.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. EARLY DETECTION OF RETINAL HEMANGIOBLASTOMAS IN VON HIPPEL-LINDAU DISEASE USING ULTRA-WIDEFIELD FLUORESCEIN ANGIOGRAPHY. Retina. 2018 Apr; 38(4):748-754. Chen X, Sanfilippo CJ, Nagiel A, Hosseini H, Mitchell D, McCannel CA, Schwartz SD, McCannel TA. PMID: 28368975.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Gene therapy for RPE65-mediated retinal dystrophies. Surv Ophthalmol. 2018 May - Jun; 63(3):445-446. Nagiel A. PMID: 29248533.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. VITRECTOMY-ASSISTED BIOPSY FOR MOLECULAR PROGNOSTICATION OF CHOROIDAL MELANOMA 2 MM OR LESS IN THICKNESS WITH A 27-GAUGE CUTTER. Retina. 2017 Jul; 37(7):1377-1382. Nagiel A, McCannel CA, Moreno C, McCannel TA. PMID: 28486310.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. THE SPECTRUM OF AMALRIC TRIANGULAR CHOROIDAL INFARCTION. Retin Cases Brief Rep. 2017 Winter; 11 Suppl 1:S113-S120. Nemiroff J, Phasukkijwatana N, Vaclavik V, Nagiel A, Holz ER, Sarraf D. PMID: 27780182.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. PARANEOPLASTIC VITELLIFORM MACULOPATHY IN THE SETTING OF CHOROIDAL MELANOMA: EVOLUTION OVER ONE YEAR. Retin Cases Brief Rep. 2017 Winter; 11 Suppl 1:S7-S10. Nagiel A, Rootman DB, McCannel TA. PMID: 27533643.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Deformation of Optic Nerve Head and Peripapillary Tissues by Horizontal Duction. Am J Ophthalmol. 2017 Feb; 174:85-94. Chang MY, Shin A, Park J, Nagiel A, Lalane RA, Schwartz SD, Demer JL. PMID: 27751810.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    23. Subretinal Transplantation of Embryonic Stem Cell-Derived Retinal Pigment Epithelium for the Treatment of Macular Degeneration: An Assessment at 4 Years. Invest Ophthalmol Vis Sci. 2016 Apr 01; 57(5):ORSFc1-9. Schwartz SD, Tan G, Hosseini H, Nagiel A. PMID: 27116660.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    24. ULTRA-WIDEFIELD FUNDUS IMAGING: A Review of Clinical Applications and Future Trends. Retina. 2016 Apr; 36(4):660-78. Nagiel A, Lalane RA, Sadda SR, Schwartz SD. PMID: 27014860.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    25. Isolated Zygomycetes Endophthalmitis: A Case Report. Ophthalmic Plast Reconstr Surg. 2015 Nov-Dec; 31(6):e145-7. Idiga J, Rootman DB, Nagiel A, Goldberg RA. PMID: 24833448.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    26. A Promising Future for Optical Coherence Tomography Angiography. JAMA Ophthalmol. 2015 Jun; 133(6):629-30. Nagiel A, Sadda SR, Sarraf D. PMID: 25856444.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    27. Type 3 neovascularization: evolution, association with pigment epithelial detachment, and treatment response as revealed by spectral domain optical coherence tomography. Retina. 2015 Apr; 35(4):638-47. Nagiel A, Sarraf D, Sadda SR, Spaide RF, Jung JJ, Bhavsar KV, Ameri H, Querques G, Freund KB. PMID: 25650713.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    28. RESOLUTION OF A GIANT PIGMENT EPITHELIAL DETACHMENT WITH HALF-DOSE AFLIBERCEPT. Retin Cases Brief Rep. 2015; 9(4):269-72. Nagiel A, Sadda SR, Schwartz SD, Sarraf D. PMID: 26237136.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    29. Mechanism of retinal pigment epithelium tear formation following intravitreal anti-vascular endothelial growth factor therapy revealed by spectral-domain optical coherence tomography. Am J Ophthalmol. 2013 Nov; 156(5):981-988.e2. Nagiel A, Freund KB, Spaide RF, Munch IC, Larsen M, Sarraf D. PMID: 23972309.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    30. Thrombophilia in patients with retinoblastoma receiving ophthalmic artery chemosurgery. Arch Ophthalmol. 2012 Dec; 130(12):1605-8. Francis JH, Gobin YP, Nagiel A, Dunkel IJ, Kucine N, Marr BP, Brodie SE, Abramson DH. PMID: 23229706.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    31. Retinopathy of prematurity residency training. Ophthalmology. 2012 Dec; 119(12):2644-5.e1-2. Nagiel A, Espiritu MJ, Wong RK, Lee TC, Lauer AK, Chiang MF, Chan RV. PMID: 23207022.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    32. Activity-independent specification of synaptic targets in the posterior lateral line of the larval zebrafish. Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21948-53. Nagiel A, Patel SH, Andor-Ardó D, Hudspeth AJ. PMID: 19996172.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    33. The transmembrane inner ear (Tmie) protein is essential for normal hearing and balance in the zebrafish. Proc Natl Acad Sci U S A. 2009 Dec 15; 106(50):21347-52. Gleason MR, Nagiel A, Jamet S, Vologodskaia M, López-Schier H, Hudspeth AJ. PMID: 19934034.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    34. Specificity of afferent synapses onto plane-polarized hair cells in the posterior lateral line of the zebrafish. J Neurosci. 2008 Aug 20; 28(34):8442-53. Nagiel A, Andor-Ardó D, Hudspeth AJ. PMID: 18716202.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    35. Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells. J Biol Chem. 2004 Sep 24; 279(39):40659-69. Gonzalez E, Nagiel A, Lin AJ, Golan DE, Michel T. PMID: 15292187.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
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