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Mark S Borchert, MD

Title(s)Clinical Associate Professor of Ophthalmology (Part-Time)
SchoolKeck School of Medicine of USC
Phone+1 323 361 4510
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    Collapse Biography 
    Collapse Education and Training
    Baylor College of MedicineMD1983
    USC Roski Eye InstituteOphthalmology Residency1987
    Massachusetts Eye & Ear InfirmaryNeuro-Ophthalmology Fellowship1988
    Collapse Awards and Honors
    Keck School of Medicine of USC1991  - 1994Resident Teaching Award
    Keck School of Medicine of USC1994Senior Resident Teaching Award
    Keck School of Medicine of USC1996Resident Teaching Award
    Keck School of Medicine of USC1999Resident Teaching Award
    Keck School of Medicine of USC2001Resident Teaching Award
    American Academy of Ophthalmology2002Achievement Award
    2006  - 2009America's Top Doctors
    2006Best Doctors in America Award
    2008Pasadena Magazine Top Doctors Award
    2009LA Magazine Best Doctors in Southern California
    2009Best Doctors in America Award
    LA Magazine2010Super Doctors Award
    2010Pasadena Magazine Top Doctors Award
    2013  - 2014Pasadena Magazine Top Doctors Award

    Collapse Overview 
    Collapse Overview
    Mark S. Borchert, MD earned a medical degree from Baylor College of Medicine. He completed his residency in the Department of Ophthalmology, University of Southern California, and a fellowship in neuro-ophthalmology at the Massachusetts Eye & Ear Infirmary, Harvard University. Dr. Borchert is the Director of Eye Birth Defects, leading the world’s largest study into optic nerve hypoplasia. Dr. Borchert, who has been listed in “Best Doctors in America,” also has received honors from the Pan American Association of Ophthalmology, the American Academy of Ophthalmology, and Society of Heed Fellows, as well as several teaching awards from the Keck School of Medicine. His research on the development of the retina and optic nerve in rats was part of an experiment on the NASA space shuttle.

    Borchert investigates the development of the optic nerve and its retinotopic connections in the tectum (part of the midbrain) and thalamus (part of the forebrain). He is interested in the role that inaccurate or inadequate development of these connections plays in the pathogenesis of optic nerve hypoplasia, the leading cause of blindness in infants in the United states and Europe. His research focus also includes developing diagnostic tools using spectroscopic methods in the measurement of glucose levels in the eye.

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Handa S, Saffari SE, Borchert M. Factors Associated With Lack of Vision Improvement in Children With Cortical Visual Impairment. J Neuroophthalmol. 2018 Dec; 38(4):429-433. PMID: 29232345.
      View in: PubMed
    2. Storey PP, Aziz HA, O'Keefe GAD, Borchert M, Lam LA, Puliafito CA, Olmos de Koo LC. Decreased severity of age-related macular degeneration in amblyopic eyes. Br J Ophthalmol. 2018 Nov; 102(11):1575-1578. PMID: 29437581.
      View in: PubMed
    3. Borchert M, Liu GT, Pineles S, Waldman AT. Pediatric Optic Neuritis: What Is New. J Neuroophthalmol. 2017 09; 37 Suppl 1:S14-S22. PMID: 28806345.
      View in: PubMed
    4. Garcia-Filion P, Almarzouki H, Fink C, Geffner M, Nelson M, Borchert M. Brain Malformations Do Not Predict Hypopituitarism in Young Children with Optic Nerve Hypoplasia. Horm Res Paediatr. 2017; 88(3-4):251-257. PMID: 28848142.
      View in: PubMed
    5. McCulloch D, Garcia-Filion P, Fink C, Fisher AC, Eleuteri A, Borchert MS. Predictive value of N95 waveforms of pattern electroretinograms (PERGs) in children with optic nerve hypoplasia (ONH). Doc Ophthalmol. 2017 10; 135(2):97-106. PMID: 28795295.
      View in: PubMed
    6. Ryabets-Lienhard A, Stewart C, Borchert M, Geffner ME. The Optic Nerve Hypoplasia Spectrum: Review of the Literature and Clinical Guidelines. Adv Pediatr. 2016 08; 63(1):127-46. PMID: 27426898.
      View in: PubMed
    7. Binder NR, Kruglyakova J, Borchert MS. Strabismus in patients with cortical visual impairment: outcomes of surgery and observations of spontaneous resolution. J AAPOS. 2016 Apr; 20(2):121-5. PMID: 27079591.
      View in: PubMed
    8. Borchert M, Bruce S, Wirta D, Yoelin SG, Lee S, Mao C, VanDenburgh A. An evaluation of the safety and efficacy of bimatoprost for eyelash growth in pediatric subjects. Clin Ophthalmol. 2016; 10:419-29. PMID: 27022239; PMCID: PMC4792214.
      View in: PubMed, PubMed Central
    9. Stewart C, Garcia-Filion P, Fink C, Ryabets-Lienhard A, Geffner ME, Borchert M. Efficacy of growth hormone replacement on anthropometric outcomes, obesity, and lipids in children with optic nerve hypoplasia and growth hormone deficiency. Int J Pediatr Endocrinol. 2016; 2016:5. PMID: 26937243; PMCID: PMC4774157.
      View in: PubMed, PubMed Central
    10. Borchert MS, Lessell S. Fanfare for the Uncommon Neuro-Ophthalmologist: A Tribute to Irma Miller Lessell. J Neuroophthalmol. 2015 Sep; 35(3):e24-5. PMID: 26505049.
      View in: PubMed
    11. Fisher AC, McCulloch DL, Borchert MS, Garcia-Filion P, Fink C, Eleuteri A, Simpson DM. Comparison of human expert and computer-automated systems using magnitude-squared coherence (MSC) and bootstrap distribution statistics for the interpretation of pattern electroretinograms (PERGs) in infants with optic nerve hypoplasia (ONH). Doc Ophthalmol. 2015 Aug; 131(1):25-34. PMID: 25761929.
      View in: PubMed
    12. Fink C, Borchert M, Simon CZ, Saper C. Hypothalamic dysfunction without hamartomas causing gelastic seizures in optic nerve hypoplasia. J Child Neurol. 2015 Feb; 30(2):233-7. PMID: 24700666.
      View in: PubMed
    13. Borchert M, Garcia-Filion P, Fink C, Geffner M, Nelson M. Re: Ramakrishnaiah et al.: Reliability of magnetic resonance imaging for the detection of hypopituitarism in children with optic nerve hypoplasia (Ophthalmology 2014;121:387-91). Ophthalmology. 2014 May; 121(5):e26-7. PMID: 24565741.
      View in: PubMed
    14. Garcia-Filion P, Borchert M. Prenatal determinants of optic nerve hypoplasia: review of suggested correlates and future focus. Surv Ophthalmol. 2013 Nov-Dec; 58(6):610-9. PMID: 24160732; PMCID: PMC3879141.
      View in: PubMed, PubMed Central
    15. Fink C, Garcia-Filion P, Borchert M. Failure of stem cell therapy to improve visual acuity in children with optic nerve hypoplasia. J AAPOS. 2013 Oct; 17(5):490-3. PMID: 24160969.
      View in: PubMed
    16. Williams ME, Fink C, Zamora I, Borchert M. Autism assessment in children with optic nerve hypoplasia and other vision impairments. Dev Med Child Neurol. 2014 Jan; 56(1):66-72. PMID: 24000901.
      View in: PubMed
    17. Wen G, Tarczy-Hornoch K, McKean-Cowdin R, Cotter SA, Borchert M, Lin J, Kim J, Varma R. Prevalence of myopia, hyperopia, and astigmatism in non-Hispanic white and Asian children: multi-ethnic pediatric eye disease study. Ophthalmology. 2013 Oct; 120(10):2109-16. PMID: 23953098.
      View in: PubMed
    18. McKean-Cowdin R, Cotter SA, Tarczy-Hornoch K, Wen G, Kim J, Borchert M, Varma R. Prevalence of amblyopia or strabismus in asian and non-Hispanic white preschool children: multi-ethnic pediatric eye disease study. Ophthalmology. 2013 Oct; 120(10):2117-24. PMID: 23697956; PMCID: PMC4848013.
      View in: PubMed, PubMed Central
    19. Tarczy-Hornoch K, Cotter SA, Borchert M, McKean-Cowdin R, Lin J, Wen G, Kim J, Varma R. Prevalence and causes of visual impairment in Asian and non-Hispanic white preschool children: Multi-ethnic Pediatric Eye Disease Study. Ophthalmology. 2013 Jun; 120(6):1220-6. PMID: 23561327; PMCID: PMC4848010.
      View in: PubMed, PubMed Central
    20. Garcia-Filion P, Borchert M. Optic nerve hypoplasia syndrome: a review of the epidemiology and clinical associations. Curr Treat Options Neurol. 2013 Feb; 15(1):78-89. PMID: 23233151; PMCID: PMC3576022.
      View in: PubMed, PubMed Central
    21. Fink C, Vedin AM, Garcia-Filion P, Ma NS, Geffner ME, Borchert M. Newborn thyroid-stimulating hormone in children with optic nerve hypoplasia: associations with hypothyroidism and vision. J AAPOS. 2012 Oct; 16(5):418-23. PMID: 23084376; PMCID: PMC3481172.
      View in: PubMed, PubMed Central
    22. Prasov L, Masud T, Khaliq S, Mehdi SQ, Abid A, Oliver ER, Silva ED, Lewanda A, Brodsky MC, Borchert M, Kelberman D, Sowden JC, Dattani MT, Glaser T. ATOH7 mutations cause autosomal recessive persistent hyperplasia of the primary vitreous. Hum Mol Genet. 2012 Aug 15; 21(16):3681-94. PMID: 22645276; PMCID: PMC3406761.
      View in: PubMed, PubMed Central
    23. Vedin AM, Garcia-Filion P, Fink C, Borchert M, Geffner ME. Serum prolactin concentrations in relation to hypopituitarism and obesity in children with optic nerve hypoplasia. Horm Res Paediatr. 2012; 77(5):277-80. PMID: 22572701; PMCID: PMC3578391.
      View in: PubMed, PubMed Central
    24. Borchert M. Reappraisal of the optic nerve hypoplasia syndrome. J Neuroophthalmol. 2012 Mar; 32(1):58-67. PMID: 22330852.
      View in: PubMed
    25. Vedin AM, Karlsson H, Fink C, Borchert M, Geffner ME. Presenting features and long-term effects of growth hormone treatment of children with optic nerve hypoplasia/septo-optic dysplasia. Int J Pediatr Endocrinol. 2011 Nov 15; 2011(1):17. PMID: 22085631; PMCID: PMC3256097.
      View in: PubMed, PubMed Central
    26. Tarczy-Hornoch K, Varma R, Cotter SA, McKean-Cowdin R, Lin JH, Borchert MS, Torres M, Wen G, Azen SP, Tielsch JM, Friedman DS, Repka MX, Katz J, Ibironke J, Giordano L. Risk factors for decreased visual acuity in preschool children: the multi-ethnic pediatric eye disease and Baltimore pediatric eye disease studies. Ophthalmology. 2011 Nov; 118(11):2262-73. PMID: 21856014; PMCID: PMC3208077.
      View in: PubMed, PubMed Central
    27. McKean-Cowdin R, Varma R, Cotter SA, Tarczy-Hornoch K, Borchert MS, Lin JH, Wen G, Azen SP, Torres M, Tielsch JM, Friedman DS, Repka MX, Katz J, Ibironke J, Giordano L. Risk factors for astigmatism in preschool children: the multi-ethnic pediatric eye disease and Baltimore pediatric eye disease studies. Ophthalmology. 2011 Oct; 118(10):1974-81. PMID: 21856010; PMCID: PMC3186875.
      View in: PubMed, PubMed Central
    28. Borchert MS, Varma R, Cotter SA, Tarczy-Hornoch K, McKean-Cowdin R, Lin JH, Wen G, Azen SP, Torres M, Tielsch JM, Friedman DS, Repka MX, Katz J, Ibironke J, Giordano L. Risk factors for hyperopia and myopia in preschool children the multi-ethnic pediatric eye disease and Baltimore pediatric eye disease studies. Ophthalmology. 2011 Oct; 118(10):1966-73. PMID: 21856013; PMCID: PMC3186878.
      View in: PubMed, PubMed Central
    29. Cotter SA, Varma R, Tarczy-Hornoch K, McKean-Cowdin R, Lin J, Wen G, Wei J, Borchert M, Azen SP, Torres M, Tielsch JM, Friedman DS, Repka MX, Katz J, Ibironke J, Giordano L. Risk factors associated with childhood strabismus: the multi-ethnic pediatric eye disease and Baltimore pediatric eye disease studies. Ophthalmology. 2011 Nov; 118(11):2251-61. PMID: 21856012; PMCID: PMC3208120.
      View in: PubMed, PubMed Central
    30. O'Neil S, Ji L, Buranahirun C, Azoff J, Dhall G, Khatua S, Patel S, Panigrahy A, Borchert M, Sposto R, Finlay J. Neurocognitive outcomes in pediatric and adolescent patients with central nervous system germinoma treated with a strategy of chemotherapy followed by reduced-dose and volume irradiation. Pediatr Blood Cancer. 2011 Oct; 57(4):669-73. PMID: 21495164.
      View in: PubMed
    31. Fozailoff A, Tarczy-Hornoch K, Cotter S, Wen G, Lin J, Borchert M, Azen S, Varma R. Prevalence of astigmatism in 6- to 72-month-old African American and Hispanic children: the Multi-ethnic Pediatric Eye Disease Study. Ophthalmology. 2011 Feb; 118(2):284-93. PMID: 20888047; PMCID: PMC3017730.
      View in: PubMed, PubMed Central
    32. Wen G, McKean-Cowdin R, Varma R, Tarczy-Hornoch K, Cotter SA, Borchert M, Azen S. General health-related quality of life in preschool children with strabismus or amblyopia. Ophthalmology. 2011 Mar; 118(3):574-80. PMID: 20884059; PMCID: PMC3017225.
      View in: PubMed, PubMed Central
    33. Ma NS, Fink C, Geffner ME, Borchert M. Evolving central hypothyroidism in children with optic nerve hypoplasia. J Pediatr Endocrinol Metab. 2010 Jan-Feb; 23(1-2):53-8. PMID: 20432806.
      View in: PubMed
    34. Borchert M, Tarczy-Hornoch K, Cotter SA, Liu N, Azen SP, Varma R. Anisometropia in Hispanic and african american infants and young children the multi-ethnic pediatric eye disease study. Ophthalmology. 2010 Jan; 117(1):148-153.e1. PMID: 19818509; PMCID: PMC2814917.
      View in: PubMed, PubMed Central
    35. Chaplin C, Borchert MS, Fink C, Garcia-Filion P, McCulloch DL. Light-adapted electroretinograms in optic nerve hypoplasia. Doc Ophthalmol. 2009 Oct; 119(2):123-32. PMID: 19669817.
      View in: PubMed
    36. Pan Y, Tarczy-Hornoch K, Cotter SA, Wen G, Borchert MS, Azen SP, Varma R. Visual acuity norms in pre-school children: the Multi-Ethnic Pediatric Eye Disease Study. Optom Vis Sci. 2009 Jun; 86(6):607-12. PMID: 19430325; PMCID: PMC2742505.
      View in: PubMed, PubMed Central
    37. Garcia-Filion P, Fink C, Geffner ME, Borchert M. Optic nerve hypoplasia in North America: a re-appraisal of perinatal risk factors. Acta Ophthalmol. 2010 Aug; 88(5):527-34. PMID: 19141149; PMCID: PMC3319088.
      View in: PubMed, PubMed Central
    38. Cotter SA, Tarczy-Hornoch K, Song E, Lin J, Borchert M, Azen SP, Varma R. Fixation preference and visual acuity testing in a population-based cohort of preschool children with amblyopia risk factors. Ophthalmology. 2009 Jan; 116(1):145-53. PMID: 18962921; PMCID: PMC2699252.
      View in: PubMed, PubMed Central
    39. Borchert M, Garcia-Filion P. The syndrome of optic nerve hypoplasia. Curr Neurol Neurosci Rep. 2008 Sep; 8(5):395-403. PMID: 18713575.
      View in: PubMed
    40. Chirapapaisan N, Borchert MS. Pediatric optic neuritis. J Med Assoc Thai. 2008 Mar; 91(3):323-30. PMID: 18575284.
      View in: PubMed
    41. Tarczy-Hornoch K, Lin J, Deneen J, Cotter SA, Azen SP, Borchert MS, Wang Y, Varma R. Stereoacuity testability in African-American and Hispanic pre-school children. Optom Vis Sci. 2008 Mar; 85(3):158-63. PMID: 18317330.
      View in: PubMed
    42. Ahmad T, Borchert M, Geffner M. Optic nerve hypoplasia and hypopituitarism. Pediatr Endocrinol Rev. 2008 Mar; 5(3):772-7. PMID: 18367998.
      View in: PubMed
    43. Garcia-Filion P, Epport K, Nelson M, Azen C, Geffner ME, Fink C, Borchert M. Neuroradiographic, endocrinologic, and ophthalmic correlates of adverse developmental outcomes in children with optic nerve hypoplasia: a prospective study. Pediatrics. 2008 Mar; 121(3):e653-9. PMID: 18250116.
      View in: PubMed
    44. Borchert M, Wang Y, Tarczy-Hornoch K, Cotter S, Deneen J, Azen S, Varma R. Testability of the Retinomax autorefractor and IOLMaster in preschool children: the Multi-ethnic Pediatric Eye Disease Study. Ophthalmology. 2008 Aug; 115(8):1422-5, 1425.e1. PMID: 18164067; PMCID: PMC4848014.
      View in: PubMed, PubMed Central
    45. Ortiz S, Borchert M. Long-term outcomes of pediatric ocular myasthenia gravis. Ophthalmology. 2008 Jul; 115(7):1245-1248.e1. PMID: 18155768.
      View in: PubMed
    46. Cotter SA, Tarczy-Hornoch K, Wang Y, Azen SP, Dilauro A, Borchert M, Varma R. Visual acuity testability in African-American and Hispanic children: the multi-ethnic pediatric eye disease study. Am J Ophthalmol. 2007 Nov; 144(5):663-7. PMID: 17868633; PMCID: PMC2099260.
      View in: PubMed, PubMed Central
    47. Engel BC, Podsakoff GM, Ireland JL, Smogorzewska EM, Carbonaro DA, Wilson K, Shah A, Kapoor N, Sweeney M, Borchert M, Crooks GM, Weinberg KI, Parkman R, Rosenblatt HM, Wu SQ, Hershfield MS, Candotti F, Kohn DB. Prolonged pancytopenia in a gene therapy patient with ADA-deficient SCID and trisomy 8 mosaicism: a case report. Blood. 2007 Jan 15; 109(2):503-6. PMID: 16973956; PMCID: PMC1785101.
      View in: PubMed, PubMed Central
    48. La Via WV, Lambert JL, Pelletier MJ, Morookian JM, Sirk SJ, Mickiene D, Walsh TJ, Borchert MS. Measurement of amphotericin B concentration by resonant Raman spectroscopy--a novel technique that may be useful for non-invasive monitoring. Med Mycol. 2006 Mar; 44(2):169-74. PMID: 16519020.
      View in: PubMed
    49. Borchert M, Lambert J, Sliney D. Validation of ICNIRP estimates of toxicity thresholds for NIR (785 nm) light in the retinas of pigmented rabbits. Health Phys. 2006 Jan; 90(1):3-10. PMID: 16340602.
      View in: PubMed
    50. Ahmad T, Garcia-Filion P, Borchert M, Kaufman F, Burkett L, Geffner M. Endocrinological and auxological abnormalities in young children with optic nerve hypoplasia: a prospective study. J Pediatr. 2006 Jan; 148(1):78-84. PMID: 16423602.
      View in: PubMed
    51. Pelletier CC, Lambert JL, Borchert M. Determination of glucose in human aqueous humor using Raman spectroscopy and designed-solution calibration. Appl Spectrosc. 2005 Aug; 59(8):1024-31. PMID: 16105211.
      View in: PubMed
    52. Lambert JL, Pelletier CC, Borchert M. Glucose determination in human aqueous humor with Raman spectroscopy. J Biomed Opt. 2005 May-Jun; 10(3):031110. PMID: 16229635.
      View in: PubMed
    53. Mitchell WG, Davalos-Gonzalez Y, Brumm VL, Aller SK, Burger E, Turkel SB, Borchert MS, Hollar S, Padilla S. Opsoclonus-ataxia caused by childhood neuroblastoma: developmental and neurologic sequelae. Pediatrics. 2002 Jan; 109(1):86-98. PMID: 11773546.
      View in: PubMed
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