Mark S Borchert, MD
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Title(s) | Clinical Associate Professor of Ophthalmology (Part-Time) |
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School | Keck School of Medicine of USC |
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Phone | +1 323 361 4510 |
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vCard | Download vCard |
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Biography Baylor College of Medicine | MD | 1983 | | USC Roski Eye Institute | Ophthalmology Residency | 1987 | | Massachusetts Eye & Ear Infirmary | Neuro-Ophthalmology Fellowship | 1988 | |
Keck School of Medicine of USC | 1991
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| 1994 | Resident Teaching Award | Keck School of Medicine of USC | 1994 | | Senior Resident Teaching Award | Keck School of Medicine of USC | 1996 | | Resident Teaching Award | Keck School of Medicine of USC | 1999 | | Resident Teaching Award | Keck School of Medicine of USC | 2001 | | Resident Teaching Award | American Academy of Ophthalmology | 2002 | | Achievement Award | | 2006
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| 2009 | America's Top Doctors | | 2006 | | Best Doctors in America Award | | 2008 | | Pasadena Magazine Top Doctors Award | | 2009 | | LA Magazine Best Doctors in Southern California | | 2009 | | Best Doctors in America Award | LA Magazine | 2010 | | Super Doctors Award | | 2010 | | Pasadena Magazine Top Doctors Award | | 2013
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| 2014 | Pasadena Magazine Top Doctors Award |
Overview Mark S. Borchert, MD earned a medical degree from Baylor College of Medicine. He completed his residency in the Department of Ophthalmology, University of Southern California, and a fellowship in neuro-ophthalmology at the Massachusetts Eye & Ear Infirmary, Harvard University. Dr. Borchert is the Director of Eye Birth Defects, leading the world’s largest study into optic nerve hypoplasia. Dr. Borchert, who has been listed in “Best Doctors in America,” also has received honors from the Pan American Association of Ophthalmology, the American Academy of Ophthalmology, and Society of Heed Fellows, as well as several teaching awards from the Keck School of Medicine. His research on the development of the retina and optic nerve in rats was part of an experiment on the NASA space shuttle.
Borchert investigates the development of the optic nerve and its retinotopic connections in the tectum (part of the midbrain) and thalamus (part of the forebrain). He is interested in the role that inaccurate or inadequate development of these connections plays in the pathogenesis of optic nerve hypoplasia, the leading cause of blindness in infants in the United states and Europe. His research focus also includes developing diagnostic tools using spectroscopic methods in the measurement of glucose levels in the eye.
ORNG Applications Bibliographic
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Handa S, Saffari SE, Borchert M. Factors Associated With Lack of Vision Improvement in Children With Cortical Visual Impairment. J Neuroophthalmol. 2018 Dec; 38(4):429-433. PMID: 29232345.
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Storey PP, Aziz HA, O'Keefe GAD, Borchert M, Lam LA, Puliafito CA, Olmos de Koo LC. Decreased severity of age-related macular degeneration in amblyopic eyes. Br J Ophthalmol. 2018 Nov; 102(11):1575-1578. PMID: 29437581.
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Borchert M, Liu GT, Pineles S, Waldman AT. Pediatric Optic Neuritis: What Is New. J Neuroophthalmol. 2017 09; 37 Suppl 1:S14-S22. PMID: 28806345.
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Garcia-Filion P, Almarzouki H, Fink C, Geffner M, Nelson M, Borchert M. Brain Malformations Do Not Predict Hypopituitarism in Young Children with Optic Nerve Hypoplasia. Horm Res Paediatr. 2017; 88(3-4):251-257. PMID: 28848142.
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McCulloch D, Garcia-Filion P, Fink C, Fisher AC, Eleuteri A, Borchert MS. Predictive value of N95 waveforms of pattern electroretinograms (PERGs) in children with optic nerve hypoplasia (ONH). Doc Ophthalmol. 2017 10; 135(2):97-106. PMID: 28795295.
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Ryabets-Lienhard A, Stewart C, Borchert M, Geffner ME. The Optic Nerve Hypoplasia Spectrum: Review of the Literature and Clinical Guidelines. Adv Pediatr. 2016 08; 63(1):127-46. PMID: 27426898.
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Binder NR, Kruglyakova J, Borchert MS. Strabismus in patients with cortical visual impairment: outcomes of surgery and observations of spontaneous resolution. J AAPOS. 2016 Apr; 20(2):121-5. PMID: 27079591.
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Borchert M, Bruce S, Wirta D, Yoelin SG, Lee S, Mao C, VanDenburgh A. An evaluation of the safety and efficacy of bimatoprost for eyelash growth in pediatric subjects. Clin Ophthalmol. 2016; 10:419-29. PMID: 27022239; PMCID: PMC4792214.
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Stewart C, Garcia-Filion P, Fink C, Ryabets-Lienhard A, Geffner ME, Borchert M. Efficacy of growth hormone replacement on anthropometric outcomes, obesity, and lipids in children with optic nerve hypoplasia and growth hormone deficiency. Int J Pediatr Endocrinol. 2016; 2016:5. PMID: 26937243; PMCID: PMC4774157.
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Borchert MS, Lessell S. Fanfare for the Uncommon Neuro-Ophthalmologist: A Tribute to Irma Miller Lessell. J Neuroophthalmol. 2015 Sep; 35(3):e24-5. PMID: 26505049.
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Fisher AC, McCulloch DL, Borchert MS, Garcia-Filion P, Fink C, Eleuteri A, Simpson DM. Comparison of human expert and computer-automated systems using magnitude-squared coherence (MSC) and bootstrap distribution statistics for the interpretation of pattern electroretinograms (PERGs) in infants with optic nerve hypoplasia (ONH). Doc Ophthalmol. 2015 Aug; 131(1):25-34. PMID: 25761929.
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Fink C, Borchert M, Simon CZ, Saper C. Hypothalamic dysfunction without hamartomas causing gelastic seizures in optic nerve hypoplasia. J Child Neurol. 2015 Feb; 30(2):233-7. PMID: 24700666.
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Borchert M, Garcia-Filion P, Fink C, Geffner M, Nelson M. Re: Ramakrishnaiah et al.: Reliability of magnetic resonance imaging for the detection of hypopituitarism in children with optic nerve hypoplasia (Ophthalmology 2014;121:387-91). Ophthalmology. 2014 May; 121(5):e26-7. PMID: 24565741.
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Garcia-Filion P, Borchert M. Prenatal determinants of optic nerve hypoplasia: review of suggested correlates and future focus. Surv Ophthalmol. 2013 Nov-Dec; 58(6):610-9. PMID: 24160732; PMCID: PMC3879141.
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Fink C, Garcia-Filion P, Borchert M. Failure of stem cell therapy to improve visual acuity in children with optic nerve hypoplasia. J AAPOS. 2013 Oct; 17(5):490-3. PMID: 24160969.
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Williams ME, Fink C, Zamora I, Borchert M. Autism assessment in children with optic nerve hypoplasia and other vision impairments. Dev Med Child Neurol. 2014 Jan; 56(1):66-72. PMID: 24000901.
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Wen G, Tarczy-Hornoch K, McKean-Cowdin R, Cotter SA, Borchert M, Lin J, Kim J, Varma R. Prevalence of myopia, hyperopia, and astigmatism in non-Hispanic white and Asian children: multi-ethnic pediatric eye disease study. Ophthalmology. 2013 Oct; 120(10):2109-16. PMID: 23953098.
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McKean-Cowdin R, Cotter SA, Tarczy-Hornoch K, Wen G, Kim J, Borchert M, Varma R. Prevalence of amblyopia or strabismus in asian and non-Hispanic white preschool children: multi-ethnic pediatric eye disease study. Ophthalmology. 2013 Oct; 120(10):2117-24. PMID: 23697956; PMCID: PMC4848013.
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Tarczy-Hornoch K, Cotter SA, Borchert M, McKean-Cowdin R, Lin J, Wen G, Kim J, Varma R. Prevalence and causes of visual impairment in Asian and non-Hispanic white preschool children: Multi-ethnic Pediatric Eye Disease Study. Ophthalmology. 2013 Jun; 120(6):1220-6. PMID: 23561327; PMCID: PMC4848010.
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Garcia-Filion P, Borchert M. Optic nerve hypoplasia syndrome: a review of the epidemiology and clinical associations. Curr Treat Options Neurol. 2013 Feb; 15(1):78-89. PMID: 23233151; PMCID: PMC3576022.
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Fink C, Vedin AM, Garcia-Filion P, Ma NS, Geffner ME, Borchert M. Newborn thyroid-stimulating hormone in children with optic nerve hypoplasia: associations with hypothyroidism and vision. J AAPOS. 2012 Oct; 16(5):418-23. PMID: 23084376; PMCID: PMC3481172.
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Prasov L, Masud T, Khaliq S, Mehdi SQ, Abid A, Oliver ER, Silva ED, Lewanda A, Brodsky MC, Borchert M, Kelberman D, Sowden JC, Dattani MT, Glaser T. ATOH7 mutations cause autosomal recessive persistent hyperplasia of the primary vitreous. Hum Mol Genet. 2012 Aug 15; 21(16):3681-94. PMID: 22645276; PMCID: PMC3406761.
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Vedin AM, Garcia-Filion P, Fink C, Borchert M, Geffner ME. Serum prolactin concentrations in relation to hypopituitarism and obesity in children with optic nerve hypoplasia. Horm Res Paediatr. 2012; 77(5):277-80. PMID: 22572701; PMCID: PMC3578391.
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Borchert M. Reappraisal of the optic nerve hypoplasia syndrome. J Neuroophthalmol. 2012 Mar; 32(1):58-67. PMID: 22330852.
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Vedin AM, Karlsson H, Fink C, Borchert M, Geffner ME. Presenting features and long-term effects of growth hormone treatment of children with optic nerve hypoplasia/septo-optic dysplasia. Int J Pediatr Endocrinol. 2011 Nov 15; 2011(1):17. PMID: 22085631; PMCID: PMC3256097.
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Tarczy-Hornoch K, Varma R, Cotter SA, McKean-Cowdin R, Lin JH, Borchert MS, Torres M, Wen G, Azen SP, Tielsch JM, Friedman DS, Repka MX, Katz J, Ibironke J, Giordano L. Risk factors for decreased visual acuity in preschool children: the multi-ethnic pediatric eye disease and Baltimore pediatric eye disease studies. Ophthalmology. 2011 Nov; 118(11):2262-73. PMID: 21856014; PMCID: PMC3208077.
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McKean-Cowdin R, Varma R, Cotter SA, Tarczy-Hornoch K, Borchert MS, Lin JH, Wen G, Azen SP, Torres M, Tielsch JM, Friedman DS, Repka MX, Katz J, Ibironke J, Giordano L. Risk factors for astigmatism in preschool children: the multi-ethnic pediatric eye disease and Baltimore pediatric eye disease studies. Ophthalmology. 2011 Oct; 118(10):1974-81. PMID: 21856010; PMCID: PMC3186875.
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Borchert MS, Varma R, Cotter SA, Tarczy-Hornoch K, McKean-Cowdin R, Lin JH, Wen G, Azen SP, Torres M, Tielsch JM, Friedman DS, Repka MX, Katz J, Ibironke J, Giordano L. Risk factors for hyperopia and myopia in preschool children the multi-ethnic pediatric eye disease and Baltimore pediatric eye disease studies. Ophthalmology. 2011 Oct; 118(10):1966-73. PMID: 21856013; PMCID: PMC3186878.
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Cotter SA, Varma R, Tarczy-Hornoch K, McKean-Cowdin R, Lin J, Wen G, Wei J, Borchert M, Azen SP, Torres M, Tielsch JM, Friedman DS, Repka MX, Katz J, Ibironke J, Giordano L. Risk factors associated with childhood strabismus: the multi-ethnic pediatric eye disease and Baltimore pediatric eye disease studies. Ophthalmology. 2011 Nov; 118(11):2251-61. PMID: 21856012; PMCID: PMC3208120.
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O'Neil S, Ji L, Buranahirun C, Azoff J, Dhall G, Khatua S, Patel S, Panigrahy A, Borchert M, Sposto R, Finlay J. Neurocognitive outcomes in pediatric and adolescent patients with central nervous system germinoma treated with a strategy of chemotherapy followed by reduced-dose and volume irradiation. Pediatr Blood Cancer. 2011 Oct; 57(4):669-73. PMID: 21495164.
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Fozailoff A, Tarczy-Hornoch K, Cotter S, Wen G, Lin J, Borchert M, Azen S, Varma R. Prevalence of astigmatism in 6- to 72-month-old African American and Hispanic children: the Multi-ethnic Pediatric Eye Disease Study. Ophthalmology. 2011 Feb; 118(2):284-93. PMID: 20888047; PMCID: PMC3017730.
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Wen G, McKean-Cowdin R, Varma R, Tarczy-Hornoch K, Cotter SA, Borchert M, Azen S. General health-related quality of life in preschool children with strabismus or amblyopia. Ophthalmology. 2011 Mar; 118(3):574-80. PMID: 20884059; PMCID: PMC3017225.
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Ma NS, Fink C, Geffner ME, Borchert M. Evolving central hypothyroidism in children with optic nerve hypoplasia. J Pediatr Endocrinol Metab. 2010 Jan-Feb; 23(1-2):53-8. PMID: 20432806.
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Borchert M, Tarczy-Hornoch K, Cotter SA, Liu N, Azen SP, Varma R. Anisometropia in Hispanic and african american infants and young children the multi-ethnic pediatric eye disease study. Ophthalmology. 2010 Jan; 117(1):148-153.e1. PMID: 19818509; PMCID: PMC2814917.
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Chaplin C, Borchert MS, Fink C, Garcia-Filion P, McCulloch DL. Light-adapted electroretinograms in optic nerve hypoplasia. Doc Ophthalmol. 2009 Oct; 119(2):123-32. PMID: 19669817.
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Pan Y, Tarczy-Hornoch K, Cotter SA, Wen G, Borchert MS, Azen SP, Varma R. Visual acuity norms in pre-school children: the Multi-Ethnic Pediatric Eye Disease Study. Optom Vis Sci. 2009 Jun; 86(6):607-12. PMID: 19430325; PMCID: PMC2742505.
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Garcia-Filion P, Fink C, Geffner ME, Borchert M. Optic nerve hypoplasia in North America: a re-appraisal of perinatal risk factors. Acta Ophthalmol. 2010 Aug; 88(5):527-34. PMID: 19141149; PMCID: PMC3319088.
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Cotter SA, Tarczy-Hornoch K, Song E, Lin J, Borchert M, Azen SP, Varma R. Fixation preference and visual acuity testing in a population-based cohort of preschool children with amblyopia risk factors. Ophthalmology. 2009 Jan; 116(1):145-53. PMID: 18962921; PMCID: PMC2699252.
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Borchert M, Garcia-Filion P. The syndrome of optic nerve hypoplasia. Curr Neurol Neurosci Rep. 2008 Sep; 8(5):395-403. PMID: 18713575.
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Chirapapaisan N, Borchert MS. Pediatric optic neuritis. J Med Assoc Thai. 2008 Mar; 91(3):323-30. PMID: 18575284.
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Tarczy-Hornoch K, Lin J, Deneen J, Cotter SA, Azen SP, Borchert MS, Wang Y, Varma R. Stereoacuity testability in African-American and Hispanic pre-school children. Optom Vis Sci. 2008 Mar; 85(3):158-63. PMID: 18317330.
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Ahmad T, Borchert M, Geffner M. Optic nerve hypoplasia and hypopituitarism. Pediatr Endocrinol Rev. 2008 Mar; 5(3):772-7. PMID: 18367998.
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Garcia-Filion P, Epport K, Nelson M, Azen C, Geffner ME, Fink C, Borchert M. Neuroradiographic, endocrinologic, and ophthalmic correlates of adverse developmental outcomes in children with optic nerve hypoplasia: a prospective study. Pediatrics. 2008 Mar; 121(3):e653-9. PMID: 18250116.
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Borchert M, Wang Y, Tarczy-Hornoch K, Cotter S, Deneen J, Azen S, Varma R. Testability of the Retinomax autorefractor and IOLMaster in preschool children: the Multi-ethnic Pediatric Eye Disease Study. Ophthalmology. 2008 Aug; 115(8):1422-5, 1425.e1. PMID: 18164067; PMCID: PMC4848014.
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Ortiz S, Borchert M. Long-term outcomes of pediatric ocular myasthenia gravis. Ophthalmology. 2008 Jul; 115(7):1245-1248.e1. PMID: 18155768.
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Cotter SA, Tarczy-Hornoch K, Wang Y, Azen SP, Dilauro A, Borchert M, Varma R. Visual acuity testability in African-American and Hispanic children: the multi-ethnic pediatric eye disease study. Am J Ophthalmol. 2007 Nov; 144(5):663-7. PMID: 17868633; PMCID: PMC2099260.
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Engel BC, Podsakoff GM, Ireland JL, Smogorzewska EM, Carbonaro DA, Wilson K, Shah A, Kapoor N, Sweeney M, Borchert M, Crooks GM, Weinberg KI, Parkman R, Rosenblatt HM, Wu SQ, Hershfield MS, Candotti F, Kohn DB. Prolonged pancytopenia in a gene therapy patient with ADA-deficient SCID and trisomy 8 mosaicism: a case report. Blood. 2007 Jan 15; 109(2):503-6. PMID: 16973956; PMCID: PMC1785101.
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La Via WV, Lambert JL, Pelletier MJ, Morookian JM, Sirk SJ, Mickiene D, Walsh TJ, Borchert MS. Measurement of amphotericin B concentration by resonant Raman spectroscopy--a novel technique that may be useful for non-invasive monitoring. Med Mycol. 2006 Mar; 44(2):169-74. PMID: 16519020.
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Borchert M, Lambert J, Sliney D. Validation of ICNIRP estimates of toxicity thresholds for NIR (785 nm) light in the retinas of pigmented rabbits. Health Phys. 2006 Jan; 90(1):3-10. PMID: 16340602.
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Ahmad T, Garcia-Filion P, Borchert M, Kaufman F, Burkett L, Geffner M. Endocrinological and auxological abnormalities in young children with optic nerve hypoplasia: a prospective study. J Pediatr. 2006 Jan; 148(1):78-84. PMID: 16423602.
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Pelletier CC, Lambert JL, Borchert M. Determination of glucose in human aqueous humor using Raman spectroscopy and designed-solution calibration. Appl Spectrosc. 2005 Aug; 59(8):1024-31. PMID: 16105211.
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Lambert JL, Pelletier CC, Borchert M. Glucose determination in human aqueous humor with Raman spectroscopy. J Biomed Opt. 2005 May-Jun; 10(3):031110. PMID: 16229635.
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Mitchell WG, Davalos-Gonzalez Y, Brumm VL, Aller SK, Burger E, Turkel SB, Borchert MS, Hollar S, Padilla S. Opsoclonus-ataxia caused by childhood neuroblastoma: developmental and neurologic sequelae. Pediatrics. 2002 Jan; 109(1):86-98. PMID: 11773546.
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