Bino Varghese, PhD

Title(s)Associate Professor Of Research Radiology
SchoolKeck School of Medicine of Usc
AddressNOR 1441 Eastlake Ave.
Off Campus
Los Angeles CA 90033
ORCID ORCID Icon0000-0002-0508-2899 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Visveswariah Technological University, Bangalore, IndiaBE2002Medical Electronics
    Wright State University, Dayton, OhioMS2005Imaging and Image Processing
    Wright State University, Dayton, OhioPhD2011Biomedical Sciences
    UCLA, Los Angeles, CAPostdoctoral2012Cellular Mechanics
    Collapse Awards and Honors
    USC's Mark and Mary Stevens Neuroimaging and Informatics Institute2017  - 2017Big Data to Knowledge Science Rotations for Advancing Discovery (RoAD-Trip) Award

    Collapse Overview 
    Collapse Overview
    Bino Varghese is an Assistant Professor of Research with expertise in imaging, image processing, quantification and biomechanics. He obtained his B.E. in Medical Electronics from Visveswariah Technological University in 2002 and his Master's degree in Biomedical Engineering with a focus in imaging and image processing, from the Wright State University at Dayton, Ohio in 2005. In 2010, he received his Ph.D. in Biomedical Sciences from Wright State University. His doctoral dissertation was titled "Quantitative Computed-Tomography Based Bone-Strength Indicators for the Identification of Low Bone-Strength Individuals in a Clinical Environment."

    In Feb 2014, he joined the Department of Radiology at USC as a Research Laboratory Specialist. His current work focuses on investigating the technical feasibility and clinical value of quantifying multi-modal imaging biomarkers across various domains with an aim to maximize data utilization and increase clinical translation.

    Collapse Research 
    Collapse Research Activities and Funding
    Reliability Assessment of CT-based Radiomics Metrics in Tissue Characterization
    USC Deans Pilot GrantMar 1, 2020 - Feb 28, 2021
    Role: PI
    Radiomic signature of CD+ T cell infiltration and PD-L1 expression in metastatic renal cell carcinoma
    American Cancer Society American Cancer SocietySep 9, 2019 - Aug 31, 2021
    Role: CoI
    Characterizing Breast Masses Using an Integrative Framework of Machine Learning and Radiomics
    Wright Foundation Wright FoundationJul 1, 2019 - Dec 31, 2020
    Role: PI
    Assessing the role of contrast-enhanced ultrasound and MV FlowTM technology of Samsung RS85 in the evaluation of renal masses
    Samsung SamsungMay 1, 2018 - Dec 31, 2020
    Role: CoI

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Technical and clinical considerations of a physical liver phantom for CT radiomics analysis. J Appl Clin Med Phys. 2024 Apr; 25(4):e14309. Varghese BA, Cen SY, Jensen K, Levy J, Andersen HK, Schulz A, Lei X, Duddalwar VA, Goodenough DJ. PMID: 38386922; PMCID: PMC11005983.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Empowering breast cancer diagnosis and radiology practice: advances in artificial intelligence for contrast-enhanced mammography. Front Radiol. 2023; 3:1326831. Kinkar KK, Fields BKK, Yamashita MW, Varghese BA. PMID: 38249158; PMCID: PMC10796447.
      View in: PubMed   Mentions:
    3. Conditional generative learning for medical image imputation. Sci Rep. 2024 01 02; 14(1):171. Raad R, Ray D, Varghese B, Hwang D, Gill I, Duddalwar V, Oberai AA. PMID: 38167932; PMCID: PMC10762085.
      View in: PubMed   Mentions:    Fields:    
    4. Investigating the role of imaging factors in the variability of CT-based texture analysis metrics. J Appl Clin Med Phys. 2024 Apr; 25(4):e14192. Varghese BA, Cen SY, Jensen K, Levy J, Andersen HK, Schulz A, Lei X, Duddalwar VA, Goodenough DJ. PMID: 37962032; PMCID: PMC11005980.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. A Narrative Review of the Use of Artificial Intelligence in Breast, Lung, and Prostate Cancer. Life (Basel). 2023 Oct 04; 13(10). Patel K, Huang S, Rashid A, Varghese B, Gholamrezanezhad A. PMID: 37895393; PMCID: PMC10608739.
      View in: PubMed   Mentions: 1  
    6. A cross-sectional study to test equivalence of low- versus intermediate-flip angle dynamic susceptibility contrast MRI measures of relative cerebral blood volume in patients with high-grade gliomas at 1.5 Tesla field strength. Front Oncol. 2023; 13:1156843. Shiroishi MS, Weinert D, Cen SY, Varghese B, Dondlinger T, Prah M, Mendoza J, Nazemi S, Ameli N, Amini N, Shohas S, Chen S, Bigjahan B, Zada G, Chen T, Neman-Ebrahim J, Chang EL, Chow FE, Fan Z, Yang W, Attenello FJ, Ye J, Kim PE, Patel VN, Lerner A, Acharya J, Hu LS, Quarles CC, Boxerman JL, Wu O, Schmainda KM. PMID: 37799462; PMCID: PMC10548232.
      View in: PubMed   Mentions: 1  
    7. Radiomics Correlation to CD68+ Tumor-Associated Macrophages in Clear Cell Renal Cell Carcinoma. Oncology. 2024; 102(3):260-270. Shieh A, Cen SY, Varghese BA, Hwang D, Lei X, Setayesh A, Siddiqi I, Aron M, Dsouza A, Gill IS, Wallace W, Duddalwar V. PMID: 37699367.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Spatial assessments in texture analysis: what the radiologist needs to know. Front Radiol. 2023; 3:1240544. Varghese BA, Fields BKK, Hwang DH, Duddalwar VA, Matcuk GR, Cen SY. PMID: 37693924; PMCID: PMC10484588.
      View in: PubMed   Mentions:
    9. Sarcopenia and body fat change as risk factors for radiologic incisional hernia following robotic nephrectomy. Skeletal Radiol. 2023 Dec; 52(12):2469-2477. Hajian S, Ghoreifi A, Cen SY, Varghese B, Lei X, Hwang D, Tran K, Tejura T, Whang G, Djaladat H, Duddalwar V. PMID: 37249596; PMCID: PMC10582134.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Radiogenomic Associations Clear Cell Renal Cell Carcinoma: An Exploratory Study. Oncology. 2023; 101(6):375-388. Liu DH, Dani KA, Reddy SS, Lei X, Demirjian NL, Hwang DH, Varghese BA, Rhie SK, Yap FY, Quinn DI, Siddiqi I, Aron M, Vaishampayan U, Zahoor H, Cen SY, Gill IS, Duddalwar VA. PMID: 37080171.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Predicting Soft Tissue Sarcoma Response to Neoadjuvant Chemotherapy Using an MRI-Based Delta-Radiomics Approach. Mol Imaging Biol. 2023 08; 25(4):776-787. Fields BKK, Demirjian NL, Cen SY, Varghese BA, Hwang DH, Lei X, Desai B, Duddalwar V, Matcuk GR. PMID: 36695966; PMCID: PMC10333397.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    12. Feasibility of using CT radiomic signatures for predicting CD8-T cell infiltration and PD-L1 expression in renal cell carcinoma. Eur J Radiol Open. 2022; 9:100440. Varghese B, Cen S, Zahoor H, Siddiqui I, Aron M, Sali A, Rhie S, Lei X, Rivas M, Liu D, Hwang D, Quinn D, Desai M, Vaishampayan U, Gill I, Duddalwar V. PMID: 36090617; PMCID: PMC9460152.
      View in: PubMed   Mentions:
    13. Radiomics quality score in renal masses: a systematic assessment on current literature. Br J Radiol. 2022 Sep 01; 95(1137):20211211. Azadikhah A, Varghese BA, Lei X, Martin-King C, Cen SY, Duddalwar VA. PMID: 35671097; PMCID: PMC10996962.
      View in: PubMed   Mentions: 1     Fields:    
    14. An Extra Set of Intelligent Eyes: Application of Artificial Intelligence in Imaging of Abdominopelvic Pathologies in Emergency Radiology. Diagnostics (Basel). 2022 May 30; 12(6). Liu J, Varghese B, Taravat F, Eibschutz LS, Gholamrezanezhad A. PMID: 35741161; PMCID: PMC9221728.
      View in: PubMed   Mentions: 5  
    15. Non-Invasive Profiling of Advanced Prostate Cancer via Multi-Parametric Liquid Biopsy and Radiomic Analysis. Int J Mol Sci. 2022 Feb 25; 23(5). Morrison G, Buckley J, Ostrow D, Varghese B, Cen SY, Werbin J, Ericson N, Cunha A, Lu YT, George T, Smith J, Quinn D, Duddalwar V, Triche T, Goldkorn A. PMID: 35269713; PMCID: PMC8910093.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    16. Characterizing breast masses using an integrative framework of machine learning and CEUS-based radiomics. J Ultrasound. 2022 Sep; 25(3):699-708. Varghese BA, Lee S, Cen S, Talebi A, Mohd P, Stahl D, Perkins M, Desai B, Duddalwar VA, Larsen LH. PMID: 35040103; PMCID: PMC9402818.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. CT-based radiomics stratification of tumor grade and TNM stage of clear cell renal cell carcinoma. Eur Radiol. 2022 Apr; 32(4):2552-2563. Demirjian NL, Varghese BA, Cen SY, Hwang DH, Aron M, Siddiqui I, Fields BKK, Lei X, Yap FY, Rivas M, Reddy SS, Zahoor H, Liu DH, Desai M, Rhie SK, Gill IS, Duddalwar V. PMID: 34757449.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    18. Benchmarking Various Radiomic Toolkit Features While Applying the Image Biomarker Standardization Initiative toward Clinical Translation of Radiomic Analysis. J Digit Imaging. 2021 10; 34(5):1156-1170. Lei M, Varghese B, Hwang D, Cen S, Lei X, Desai B, Azadikhah A, Oberai A, Duddalwar V. PMID: 34545475; PMCID: PMC8554949.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    19. A Radiomic-based Machine Learning Algorithm to Reliably Differentiate Benign Renal Masses from Renal Cell Carcinoma. Eur Urol Focus. 2022 07; 8(4):988-994. Nassiri N, Maas M, Cacciamani G, Varghese B, Hwang D, Lei X, Aron M, Desai M, Oberai AA, Cen SY, Gill IS, Duddalwar VA. PMID: 34538748.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    20. Predicting clinical outcomes in COVID-19 using radiomics on chest radiographs. Br J Radiol. 2021 Oct 01; 94(1126):20210221. Varghese BA, Shin H, Desai B, Gholamrezanezhad A, Lei X, Perkins M, Oberai A, Nanda N, Cen S, Duddalwar V. PMID: 34520246; PMCID: PMC9328073.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    21. Whole-tumor 3D volumetric MRI-based radiomics approach for distinguishing between benign and malignant soft tissue tumors. Eur Radiol. 2021 Nov; 31(11):8522-8535. Fields BKK, Demirjian NL, Hwang DH, Varghese BA, Cen SY, Lei X, Desai B, Duddalwar V, Matcuk GR. PMID: 33893534.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    22. Machine learning based predictors for COVID-19 disease severity. Sci Rep. 2021 02 25; 11(1):4673. Patel D, Kher V, Desai B, Lei X, Cen S, Nanda N, Gholamrezanezhad A, Duddalwar V, Varghese B, Oberai AA. PMID: 33633145; PMCID: PMC7907061.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    23. Identification of robust and reproducible CT-texture metrics using a customized 3D-printed texture phantom. J Appl Clin Med Phys. 2021 Feb; 22(2):98-107. Varghese BA, Hwang D, Cen SY, Lei X, Levy J, Desai B, Goodenough DJ, Duddalwar VA. PMID: 33434374; PMCID: PMC7882093.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    24. Shape and texture-based radiomics signature on CT effectively discriminates benign from malignant renal masses. Eur Radiol. 2021 Feb; 31(2):1011-1021. Yap FY, Varghese BA, Cen SY, Hwang DH, Lei X, Desai B, Lau C, Yang LL, Fullenkamp AJ, Hajian S, Rivas M, Gupta MN, Quinn BD, Aron M, Desai MM, Aron M, Oberai AA, Gill IS, Duddalwar VA. PMID: 32803417.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    25. Quantitative magnetic resonance imaging (q-MRI) for the assessment of soft-tissue sarcoma treatment response: a narrative case review of technique development. Clin Imaging. 2020 Jul; 63:83-93. Fields BKK, Hwang D, Cen S, Desai B, Gulati M, Hu J, Duddalwar V, Varghese B, Matcuk GR. PMID: 32163847.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    26. Myocardial Radiomics in Cardiac MRI. AJR Am J Roentgenol. 2020 03; 214(3):536-545. Hassani C, Saremi F, Varghese BA, Duddalwar V. PMID: 31799865.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    27. Reliability of CT-based texture features: Phantom study. J Appl Clin Med Phys. 2019 Aug; 20(8):155-163. Varghese BA, Hwang D, Cen SY, Levy J, Liu D, Lau C, Rivas M, Desai B, Goodenough DJ, Duddalwar VA. PMID: 31222919; PMCID: PMC6698768.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    28. Juxtatumoral perinephric fat analysis in clear cell renal cell carcinoma. Abdom Radiol (NY). 2019 04; 44(4):1470-1480. Gill TS, Varghese BA, Hwang DH, Cen SY, Aron M, Aron M, Duddalwar VA. PMID: 30506142.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    29. Objective risk stratification of prostate cancer using machine learning and radiomics applied to multiparametric magnetic resonance images. Sci Rep. 2019 02 07; 9(1):1570. Varghese B, Chen F, Hwang D, Palmer SL, De Castro Abreu AL, Ukimura O, Aron M, Aron M, Gill I, Duddalwar V, Pandey G. PMID: 30733585; PMCID: PMC6367324.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    30. Texture Analysis of Imaging: What Radiologists Need to Know. AJR Am J Roentgenol. 2019 03; 212(3):520-528. Varghese BA, Cen SY, Hwang DH, Duddalwar VA. PMID: 30645163.
      View in: PubMed   Mentions: 85     Fields:    Translation:Humans
    31. Radiomics in Pulmonary Lesion Imaging. AJR Am J Roentgenol. 2019 03; 212(3):497-504. Hassani C, Varghese BA, Nieva J, Duddalwar V. PMID: 30620678.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    32. Computed tomography-based texture analysis of bladder cancer: differentiating urothelial carcinoma from micropapillary carcinoma. Abdom Radiol (NY). 2019 01; 44(1):201-208. Fan TW, Malhi H, Varghese B, Cen S, Hwang D, Aron M, Rajarubendra N, Desai M, Duddalwar V. PMID: 30022220.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    33. A Decision-Support Tool for Renal Mass Classification. J Digit Imaging. 2018 12; 31(6):929-939. Kunapuli G, Varghese BA, Ganapathy P, Desai B, Cen S, Aron M, Gill I, Duddalwar V. PMID: 29980960; PMCID: PMC6261185.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    34. Differentiation of Predominantly Solid Enhancing Lipid-Poor Renal Cell Masses by Use of Contrast-Enhanced CT: Evaluating the Role of Texture in Tumor Subtyping. AJR Am J Roentgenol. 2018 12; 211(6):W288-W296. Varghese BA, Chen F, Hwang DH, Cen SY, Desai B, Gill IS, Duddalwar VA. PMID: 30240299.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    35. Incidental Detection of Meningioma by 18F-FMAU PET/CT in a Patient With Suspected Prostate Cancer. Clin Nucl Med. 2018 Jul; 43(7):e245-e246. Varghese B, Velez E, Desai B, Jadvar H. PMID: 29742600; PMCID: PMC5980759.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    36. Differentiating solid, non-macroscopic fat containing, enhancing renal masses using fast Fourier transform analysis of multiphase CT. Br J Radiol. 2018 Sep; 91(1089):20170789. Varghese BA, Chen F, Hwang DH, Cen SY, Gill IS, Duddalwar VA. PMID: 29888982; PMCID: PMC6223167.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    37. Quantitative Contour Analysis as an Image-based Discriminator Between Benign and Malignant Renal Tumors. Urology. 2018 Apr; 114:121-127. Yap FY, Hwang DH, Cen SY, Varghese BA, Desai B, Quinn BD, Gupta MN, Rajarubendra N, Desai MM, Aron M, Liang G, Aron M, Gill IS, Duddalwar VA. PMID: 29305199.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    38. Voxel-based whole-lesion enhancement parameters: a study of its clinical value in differentiating clear cell renal cell carcinoma from renal oncocytoma. Abdom Radiol (NY). 2017 02; 42(2):552-560. Chen F, Gulati M, Hwang D, Cen S, Yap F, Ugwueze C, Varghese B, Desai M, Aron M, Gill I, Duddalwar V. PMID: 27595574.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    39. Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers. Nat Commun. 2015 Aug 03; 6:7839. He S, Zhao Z, Yang Y, O'Connell D, Zhang X, Oh S, Ma B, Lee JH, Zhang T, Varghese B, Yip J, Dolatshahi Pirooz S, Li M, Zhang Y, Li GM, Ellen Martin S, Machida K, Liang C. PMID: 26234763; PMCID: PMC4526116.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    40. A microfluidic technique to probe cell deformability. J Vis Exp. 2014 Sep 03; (91):e51474. Hoelzle DJ, Varghese BA, Chan CK, Rowat AC. PMID: 25226269; PMCID: PMC4828024.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
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