Michael Jakowec, PhD

Title(s)Professor of Research Neurology
SchoolKeck School of Medicine of Usc
AddressMCA 243
Health Sciences Campus
Los Angeles CA 90089-9153
Phone+1 323 442 1057
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    The primary focus of research in Dr. Jakowec's laboratory is to better understand the molecular mechanisms involved in neuroplasticity in the injured brain with the emphasis on the basal ganglia, a region of the brain responsible for motor behavior. Currently, his laboratory is exploring the interactions between the neurotransmitter systems involving dopamine, glutamate and serotonine and finding ways to manipulate them to enhance motor behavior. To achieve this goal, animal models of basal gagnglia injury using the neurotoxicant MPTP are being used to investigate intrinsic neuroplasticity as well as using both pharmacological and behavioral modification including intensive treadmill exercise to alter the course of response to injury. Techniques and approaches used in the lab to examine alterations in genes and proteins of interest include immunocytochemistry, in situ hybridization histochemistry, western immunoblotting, light microscopy, gene array, protein profiling, neurochemistry, electrophysiology (with John Walsh), PET imaging (with Giselle Petzinger), blood flow studies (with Daniel Holschneider), immune analysis (with Brett Lund), and behavior (with Ruth Wood). A major goal of these studies is to translate their findings to develop new therapeutic treatments for Parkinson's disease and to possibly alter disease progression and demonstrated in our recent publication (Fisher et al, 2008)

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    Anabolic-androgenic steroids promote risky decision making
    NIH R01DA029613Jul 1, 2010 - Mar 31, 2021
    Role: Co-Principal Investigator
    Glutamate-Dopamine Plasticity in Nigrostriatal Injury: Excerise Enhanced Recovery
    NIH R01NS044327Jun 1, 2002 - May 31, 2012
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. A naturally occurring variant of SHLP2 is a protective factor in Parkinson's disease. Mol Psychiatry. 2024 Jan 03. Kim SJ, Miller B, Hartel NG, Ramirez R, Braniff RG, Leelaprachakul N, Huang A, Wang Y, Arpawong TE, Crimmins EM, Wang P, Sun X, Liu C, Levy D, Yen K, Petzinger GM, Graham NA, Jakowec MW, Cohen P. PMID: 38167865.
      View in: PubMed   Mentions:    Fields:    
    2. Increased perivascular space volume in white matter and basal ganglia is associated with cognition in Parkinson's Disease. Brain Imaging Behav. 2024 Feb; 18(1):57-65. Donahue EK, Foreman RP, Duran JJ, Jakowec MW, O'Neill J, Petkus AJ, Holschneider DP, Choupan J, Van Horn JD, Venkadesh S, Bayram E, Litvan I, Schiehser DM, Petzinger GM. PMID: 37855955; PMCID: PMC10844402.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Exercise alters cortico-basal ganglia network metabolic connectivity: a mesoscopic level analysis informed by anatomic parcellation defined in the mouse brain connectome. Brain Struct Funct. 2023 Nov; 228(8):1865-1884. Wang Z, Donahue EK, Guo Y, Renteln M, Petzinger GM, Jakowec MW, Holschneider DP. PMID: 37306809; PMCID: PMC10516800.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    4. Physical activity intensity is associated with cognition and functional connectivity in Parkinson's disease. Parkinsonism Relat Disord. 2022 Nov; 104:7-14. Donahue EK, Venkadesh S, Bui V, Tuazon AC, Wang RK, Haase D, Foreman RP, Duran JJ, Petkus A, Wing D, Higgins M, Holschneider DP, Bayram E, Litvan I, Jakowec MW, Van Horn JD, Schiehser DM, Petzinger GM. PMID: 36191358.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    5. A mind in motion: Exercise improves cognitive flexibility, impulsivity and alters dopamine receptor gene expression in a Parkinsonian rat model. Curr Res Neurobiol. 2022; 3:100039. Zhuo W, Lundquist AJ, Donahue EK, Guo Y, Phillips D, Petzinger GM, Jakowec MW, Holschneider DP. PMID: 36518341; PMCID: PMC9743054.
      View in: PubMed   Mentions: 2  
    6. Promoting Physical Activity in a Spanish-Speaking Latina Population of Low Socioeconomic Status With Chronic Neurological Disorders: Proof-of-Concept Study. JMIR Form Res. 2022 Apr 20; 6(4):e34312. Garbin A, Díaz J, Bui V, Morrison J, Fisher BE, Palacios C, Estrada-Darley I, Haase D, Wing D, Amezcua L, Jakowec MW, Kaplan C, Petzinger G. PMID: 35442197; PMCID: PMC9069293.
      View in: PubMed   Mentions:
    7. Magnetic resonance spectroscopy shows associations between neurometabolite levels and perivascular space volume in Parkinson's disease: a pilot and feasibility study. Neuroreport. 2022 05 04; 33(7):291-296. Donahue EK, Bui V, Foreman RP, Duran JJ, Venkadesh S, Choupan J, Van Horn JD, Alger JR, Jakowec MW, Petzinger GM, O'Neill J. PMID: 35594442.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    8. Knockdown of Astrocytic Monocarboxylate Transporter 4 in the Motor Cortex Leads to Loss of Dendritic Spines and a Deficit in Motor Learning. Mol Neurobiol. 2022 Feb; 59(2):1002-1017. Lundquist AJ, Llewellyn GN, Kishi SH, Jakowec NA, Cannon PM, Petzinger GM, Jakowec MW. PMID: 34822124.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    9. The Effects of Cardiorespiratory and Motor Skill Fitness on Intrinsic Functional Connectivity of Neural Networks in Individuals with Parkinson's Disease. Brain Plast. 2021; 7(2):77-95. Jarrahi B, McEwen SC, Holschneider DP, Schiehser DM, Petkus AJ, Gomez ME, Van Horn JD, Filoteo V, Jakowec MW, Petzinger GM. PMID: 34868875; PMCID: PMC8609487.
      View in: PubMed   Mentions: 1  
    10. Cognition and motor learning in a Parkinson's disease cohort: importance of recall in episodic memory. Neuroreport. 2021 10 06; 32(14):1153-1160. Chung YC, Fisher BE, Finley JM, Kim A, Petkus AJ, Schiehser DM, Jakowec MW, Petzinger GM. PMID: 34334776.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    11. Thalamic volume mediates associations between cardiorespiratory fitness (VO2max) and cognition in Parkinson's disease. Parkinsonism Relat Disord. 2021 05; 86:19-26. Petkus AJ, Jarrahi B, Holschneider DP, Gomez ME, Filoteo JV, Schiehser DM, Fisher BE, Van Horn JD, Jakowec MW, McEwen SC, Petzinger G. PMID: 33819900; PMCID: PMC8375572.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    12. Exogenous l-lactate promotes astrocyte plasticity but is not sufficient for enhancing striatal synaptogenesis or motor behavior in mice. J Neurosci Res. 2021 05; 99(5):1433-1447. Lundquist AJ, Gallagher TJ, Petzinger GM, Jakowec MW. PMID: 33629362.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    13. Global and Regional Changes in Perivascular Space in Idiopathic and Familial Parkinson's Disease. Mov Disord. 2021 05; 36(5):1126-1136. Donahue EK, Murdos A, Jakowec MW, Sheikh-Bahaei N, Toga AW, Petzinger GM, Sepehrband F. PMID: 33470460; PMCID: PMC8127386.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    14. Cognitive flexibility deficits in rats with dorsomedial striatal 6-hydroxydopamine lesions tested using a three-choice serial reaction time task with reversal learning. Neuroreport. 2020 10 14; 31(15):1055-1064. Wang Z, Flores I, Donahue EK, Lundquist AJ, Guo Y, Petzinger GM, Jakowec MW, Holschneider DP. PMID: 32881776.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    15. The macrocyclic lactones ivermectin and moxidectin show differential effects on rotational behavior in the 6-hydroxydopamine mouse model of Parkinson's disease. Behav Brain Res. 2020 09 01; 393:112804. Warnecke AMP, Kang MS, Jakowec MW, Davies DL. PMID: 32668263.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    16. Mild cognitive impairment, psychiatric symptoms, and executive functioning in patients with Parkinson's disease. Int J Geriatr Psychiatry. 2020 04; 35(4):396-404. Petkus AJ, Filoteo JV, Schiehser DM, Gomez ME, Hui JS, Jarrahi B, McEwen S, Jakowec MW, Petzinger GM. PMID: 31894601.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    17. Treadmill exercise rescues mitochondrial function and motor behavior in the CAG140 knock-in mouse model of Huntington's disease. Chem Biol Interact. 2020 Jan 05; 315:108907. Caldwell CC, Petzinger GM, Jakowec MW, Cadenas E. PMID: 31778667.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    18. Dopamine Receptor Blockade Attenuates Purinergic P2X4 Receptor-Mediated Prepulse Inhibition Deficits and Underlying Molecular Mechanisms. Front Cell Neurosci. 2019; 13:331. Khoja S, Asatryan L, Jakowec MW, Davies DL. PMID: 31396053; PMCID: PMC6664007.
      View in: PubMed   Mentions: 7  
    19. Intensive treadmill exercise increases expression of hypoxia-inducible factor 1α and its downstream transcript targets: a potential role in neuroplasticity. Neuroreport. 2019 06 12; 30(9):619-627. Halliday MR, Abeydeera D, Lundquist AJ, Petzinger GM, Jakowec MW. PMID: 31045849.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    20. Exercise induces region-specific remodeling of astrocyte morphology and reactive astrocyte gene expression patterns in male mice. J Neurosci Res. 2019 09; 97(9):1081-1094. Lundquist AJ, Parizher J, Petzinger GM, Jakowec MW. PMID: 31175682.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    21. Preclinical evaluation of avermectins as novel therapeutic agents for alcohol use disorders. Psychopharmacology (Berl). 2018 06; 235(6):1697-1709. Khoja S, Huynh N, Warnecke AMP, Asatryan L, Jakowec MW, Davies DL. PMID: 29500584; PMCID: PMC5949264.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    22. The Oxygen Paradox, the French Paradox, and age-related diseases. Geroscience. 2017 12; 39(5-6):499-550. Davies JMS, Cillard J, Friguet B, Cadenas E, Cadet J, Cayce R, Fishmann A, Liao D, Bulteau AL, Derbré F, Rébillard A, Burstein S, Hirsch E, Kloner RA, Jakowec M, Petzinger G, Sauce D, Sennlaub F, Limon I, Ursini F, Maiorino M, Economides C, Pike CJ, Cohen P, Salvayre AN, Halliday MR, Lundquist AJ, Jakowec NA, Mechta-Grigoriou F, Mericskay M, Mariani J, Li Z, Huang D, Grant E, Forman HJ, Finch CE, Sun PY, Pomatto LCD, Agbulut O, Warburton D, Neri C, Rouis M, Cillard P, Capeau J, Rosenbaum J, Davies KJA. PMID: 29270905; PMCID: PMC5745211.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    23. Treadmill exercise modifies dopamine receptor expression in the prefrontal cortex of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of Parkinson's disease. Neuroreport. 2017 Oct 18; 28(15):987-995. Kintz N, Petzinger GM, Jakowec MW. PMID: 28877102.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    24. Reduced expression of purinergic P2X4 receptors increases voluntary ethanol intake in C57BL/6J mice. Alcohol. 2018 05; 68:63-70. Khoja S, Huynh N, Asatryan L, Jakowec MW, Davies DL. PMID: 29477921; PMCID: PMC5878121.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    25. Treadmill exercise delays the onset of non-motor behaviors and striatal pathology in the CAG140 knock-in mouse model of Huntington's disease. Neurobiol Dis. 2017 Sep; 105:15-32. Stefanko DP, Shah VD, Yamasaki WK, Petzinger GM, Jakowec MW. PMID: 28502806.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    26. Preclinical development of moxidectin as a novel therapeutic for alcohol use disorder. Neuropharmacology. 2017 02; 113(Pt A):60-70. Huynh N, Arabian N, Naito A, Louie S, Jakowec MW, Asatryan L, Davies DL. PMID: 27641072; PMCID: PMC5148646.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    27. Engaging cognitive circuits to promote motor recovery in degenerative disorders. exercise as a learning modality. J Hum Kinet. 2016 Sep 01; 52:35-51. Jakowec MW, Wang Z, Holschneider D, Beeler J, Petzinger GM. PMID: 28149392; PMCID: PMC5260516.
      View in: PubMed   Mentions: 4  
    28. Role of purinergic P2X4 receptors in regulating striatal dopamine homeostasis and dependent behaviors. J Neurochem. 2016 10; 139(1):134-48. Khoja S, Shah V, Garcia D, Asatryan L, Jakowec MW, Davies DL. PMID: 27402173; PMCID: PMC5037001.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    29. Evidence of functional brain reorganization on the basis of blood flow changes in the CAG140 knock-in mouse model of Huntington's disease. Neuroreport. 2016 06 15; 27(9):632-9. Wang Z, Stefanko DP, Guo Y, Toy WA, Petzinger GM, Jakowec MW, Holschneider DP. PMID: 27082842.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    30. The Effects of Exercise on Dopamine Neurotransmission in Parkinson's Disease: Targeting Neuroplasticity to Modulate Basal Ganglia Circuitry. Brain Plast. 2015; 1(1):29-39. Petzinger GM, Holschneider DP, Fisher BE, McEwen S, Kintz N, Halliday M, Toy W, Walsh JW, Beeler J, Jakowec MW. PMID: 26512345; PMCID: PMC4621077.
      View in: PubMed   Mentions: 46  
    31. P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disorders. Front Neurosci. 2014; 8:176. Franklin KM, Asatryan L, Jakowec MW, Trudell JR, Bell RL, Davies DL. PMID: 25009459; PMCID: PMC4068020.
      View in: PubMed   Mentions: 35  
    32. Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. Neurobiol Dis. 2014 Mar; 63:201-9. Toy WA, Petzinger GM, Leyshon BJ, Akopian GK, Walsh JP, Hoffman MV, Vuckovic MG, Jakowec MW. PMID: 24316165; PMCID: PMC3940446.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    33. Functional reorganization of motor and limbic circuits after exercise training in a rat model of bilateral parkinsonism. PLoS One. 2013; 8(11):e80058. Wang Z, Myers KG, Guo Y, Ocampo MA, Pang RD, Jakowec MW, Holschneider DP. PMID: 24278239; PMCID: PMC3836982.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    34. The Enemy within: Propagation of Aberrant Corticostriatal Learning to Cortical Function in Parkinson's Disease. Front Neurol. 2013; 4:134. Beeler JA, Petzinger G, Jakowec MW. PMID: 24062721; PMCID: PMC3770942.
      View in: PubMed   Mentions: 16  
    35. Exercise modifies α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor expression in striatopallidal neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse. J Neurosci Res. 2013 Nov; 91(11):1492-507. Kintz N, Petzinger GM, Akopian G, Ptasnik S, Williams C, Jakowec MW, Walsh JP. PMID: 23918451.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    36. Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson's disease. Neuroreport. 2013 Jul 10; 24(10):509-14. Fisher BE, Li Q, Nacca A, Salem GJ, Song J, Yip J, Hui JS, Jakowec MW, Petzinger GM. PMID: 23636255.
      View in: PubMed   Mentions: 81     Fields:    Translation:Humans
    37. Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease. Lancet Neurol. 2013 Jul; 12(7):716-26. Petzinger GM, Fisher BE, McEwen S, Beeler JA, Walsh JP, Jakowec MW. PMID: 23769598; PMCID: PMC3690528.
      View in: PubMed   Mentions: 244     Fields:    Translation:HumansAnimalsCells
    38. Sociocommunicative and sensorimotor impairments in male P2X4-deficient mice. Neuropsychopharmacology. 2013 Sep; 38(10):1993-2002. Wyatt LR, Godar SC, Khoja S, Jakowec MW, Alkana RL, Bortolato M, Davies DL. PMID: 23604007; PMCID: PMC3746707.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    39. 'Roid rage in rats? Testosterone effects on aggressive motivation, impulsivity and tyrosine hydroxylase. Physiol Behav. 2013 Feb 17; 110-111:6-12. Wood RI, Armstrong A, Fridkin V, Shah V, Najafi A, Jakowec M. PMID: 23266798; PMCID: PMC3615053.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    40. Brief mitochondrial inhibition causes lasting changes in motor behavior and corticostriatal synaptic physiology in the Fischer 344 rat. Neuroscience. 2012 Jul 26; 215:149-59. Akopian G, Crawford C, Petzinger G, Jakowec MW, Walsh JP. PMID: 22554779; PMCID: PMC3371111.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    41. MPTP Neurotoxicity and Testosterone Induce Dendritic Remodeling of Striatal Medium Spiny Neurons in the C57Bl/6 Mouse. Parkinsons Dis. 2011; 2011:138471. Antzoulatos E, Jakowec MW, Petzinger GM, Wood RI. PMID: 21765998; PMCID: PMC3134993.
      View in: PubMed   Mentions: 12  
    42. The role of exercise in facilitating basal ganglia function in Parkinson's disease. Neurodegener Dis Manag. 2011 Apr 01; 1(2):157-170. Petzinger GM, Fisher BE, Akopian G, Holschneider DP, Wood R, Walsh JP, Lund B, Meshul C, Vuckovic M, Jakowec MW. PMID: 23805167; PMCID: PMC3691073.
      View in: PubMed   Mentions: 5     Fields:    
    43. Exercise elevates dopamine D2 receptor in a mouse model of Parkinson's disease: in vivo imaging with [¹⁸F]fallypride. Mov Disord. 2010 Dec 15; 25(16):2777-84. Vuckovic MG, Li Q, Fisher B, Nacca A, Leahy RM, Walsh JP, Mukherjee J, Williams C, Jakowec MW, Petzinger GM. PMID: 20960487; PMCID: PMC3273304.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    44. Acute and long-term response of dopamine nigrostriatal synapses to a single, low-dose episode of 3-nitropropionic acid-mediated chemical hypoxia. Synapse. 2011 Apr; 65(4):339-50. Crawford CA, Akopian G, Ring J, Jakowec MW, Petzinger GM, Andersen JK, Vittozzi-Wong P, Wang K, Farley CM, Charntikov S, Mitroi D, Beal MF, Chow R, Walsh JP. PMID: 20730800; PMCID: PMC3032029.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    45. Exercise effects on motor and affective behavior and catecholamine neurochemistry in the MPTP-lesioned mouse. Behav Brain Res. 2010 Dec 01; 213(2):253-62. Gorton LM, Vuckovic MG, Vertelkina N, Petzinger GM, Jakowec MW, Wood RI. PMID: 20472000; PMCID: PMC2902645.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    46. Sex differences in motor behavior in the MPTP mouse model of Parkinson's disease. Pharmacol Biochem Behav. 2010 Jun; 95(4):466-72. Antzoulatos E, Jakowec MW, Petzinger GM, Wood RI. PMID: 20347863; PMCID: PMC2866026.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    47. Altered AMPA receptor expression with treadmill exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury. J Neurosci Res. 2010 Feb 15; 88(3):650-68. VanLeeuwen JE, Petzinger GM, Walsh JP, Akopian GK, Vuckovic M, Jakowec MW. PMID: 19746427.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    48. Enhancing neuroplasticity in the basal ganglia: the role of exercise in Parkinson's disease. Mov Disord. 2010; 25 Suppl 1:S141-5. Petzinger GM, Fisher BE, Van Leeuwen JE, Vukovic M, Akopian G, Meshul CK, Holschneider DP, Nacca A, Walsh JP, Jakowec MW. PMID: 20187247; PMCID: PMC4111643.
      View in: PubMed   Mentions: 73     Fields:    Translation:Humans
    49. Decreased striatal dopamine release underlies increased expression of long-term synaptic potentiation at corticostriatal synapses 24 h after 3-nitropropionic-acid-induced chemical hypoxia. J Neurosci. 2008 Sep 17; 28(38):9585-97. Akopian G, Crawford C, Beal MF, Cappelletti M, Jakowec MW, Petzinger GM, Zheng L, Gheorghe SL, Reichel CM, Chow R, Walsh JP. PMID: 18799690; PMCID: PMC2724653.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    50. Memory, mood, dopamine, and serotonin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury. Neurobiol Dis. 2008 Nov; 32(2):319-27. Vuckovic MG, Wood RI, Holschneider DP, Abernathy A, Togasaki DM, Smith A, Petzinger GM, Jakowec MW. PMID: 18718537; PMCID: PMC3280725.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    51. The effect of exercise training in improving motor performance and corticomotor excitability in people with early Parkinson's disease. Arch Phys Med Rehabil. 2008 Jul; 89(7):1221-9. Fisher BE, Wu AD, Salem GJ, Song J, Lin CH, Yip J, Cen S, Gordon J, Jakowec M, Petzinger G. PMID: 18534554; PMCID: PMC2989816.
      View in: PubMed   Mentions: 142     Fields:    Translation:Humans
    52. Effects of treadmill exercise on dopaminergic transmission in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury. J Neurosci. 2007 May 16; 27(20):5291-300. Petzinger GM, Walsh JP, Akopian G, Hogg E, Abernathy A, Arevalo P, Turnquist P, Vuckovic M, Fisher BE, Togasaki DM, Jakowec MW. PMID: 17507552; PMCID: PMC6672356.
      View in: PubMed   Mentions: 133     Fields:    Translation:AnimalsCells
    53. Association of MBP peptides with Hsp70 in normal appearing human white matter. J Neurol Sci. 2006 Nov 15; 249(2):122-34. Lund BT, Chakryan Y, Ashikian N, Mnatsakanyan L, Bevan CJ, Aguilera R, Gallaher T, Jakowec MW. PMID: 16842822.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    54. Behavioral motor recovery in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned squirrel monkey (Saimiri sciureus): changes in striatal dopamine and expression of tyrosine hydroxylase and dopamine transporter proteins. J Neurosci Res. 2006 Feb 01; 83(2):332-47. Petzinger GM, Fisher B, Hogg E, Abernathy A, Arevalo P, Nixon K, Jakowec MW. PMID: 16385585.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    55. High and low responders to novelty show differential effects in striatal glutamate. Synapse. 2005 Dec 01; 58(3):200-7. Shakil SS, Holmer HK, Moore C, Abernathy AT, Jakowec MW, Petzinger GM, Meshul CK. PMID: 16138315.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    56. Differential regulation of the growth-associated proteins GAP-43 and superior cervical ganglion 10 in response to lesions of the cortex and substantia nigra in the adult rat. Neuroscience. 2005; 135(4):1231-9. Hughes-Davis EJ, Cogen JP, Jakowec MW, Cheng HW, Grenningloh G, Meshul CK, McNeill TH. PMID: 16165289.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    57. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned model of parkinson's disease, with emphasis on mice and nonhuman primates. Comp Med. 2004 Oct; 54(5):497-513. Jakowec MW, Petzinger GM. PMID: 15575363.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimals
    58. Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse basal ganglia. J Neurosci Res. 2004 Aug 01; 77(3):378-90. Fisher BE, Petzinger GM, Nixon K, Hogg E, Bremmer S, Meshul CK, Jakowec MW. PMID: 15248294.
      View in: PubMed   Mentions: 117     Fields:    Translation:Animals
    59. Tyrosine hydroxylase and dopamine transporter expression following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of the mouse nigrostriatal pathway. J Neurosci Res. 2004 May 15; 76(4):539-50. Jakowec MW, Nixon K, Hogg E, McNeill T, Petzinger GM. PMID: 15114626.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    60. Human neural stem cell transplantation in the MPTP-lesioned mouse. Brain Res. 2003 May 09; 971(2):168-77. Liker MA, Petzinger GM, Nixon K, McNeill T, Jakowec MW. PMID: 12706233.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    61. The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety. J Neurochem. 2001 Mar; 76(5):1265-74. Przedborski S, Jackson-Lewis V, Naini AB, Jakowec M, Petzinger G, Miller R, Akram M. PMID: 11238711.
      View in: PubMed   Mentions: 166     Fields:    Translation:HumansAnimals
    62. Reliability and validity of a new global dyskinesia rating scale in the MPTP-lesioned non-human primate. Mov Disord. 2001 Mar; 16(2):202-7. Petzinger GM, Quik M, Ivashina E, Jakowec MW, Jakubiak M, Di Monte D, Langston JW. PMID: 11295771.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    63. Localization of nicotinic receptor subunit mRNAs in monkey brain by in situ hybridization. J Comp Neurol. 2000 Sep 11; 425(1):58-69. Quik M, Polonskaya Y, Gillespie A, Jakowec M, Lloyd GK, Langston JW. PMID: 10940942.
      View in: PubMed   Mentions: 58     Fields:    Translation:Animals
    64. Combined assessment of tau and neuronal thread protein in Alzheimer's disease CSF. Neurology. 2000 Apr 11; 54(7):1498-504. Kahle PJ, Jakowec M, Teipel SJ, Hampel H, Petzinger GM, Di Monte DA, Silverberg GD, Möller HJ, Yesavage JA, Tinklenberg JR, Shooter EM, Murphy GM. PMID: 10751266.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCTClinical Trials
    65. Investigating levodopa-induced dyskinesias in the parkinsonian primate. Ann Neurol. 2000 Apr; 47(4 Suppl 1):S79-89. Langston JW, Quik M, Petzinger G, Jakowec M, Di Monte DA. PMID: 10762135.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    66. Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP. J Neurochem. 2000 Feb; 74(2):721-9. Vila M, Vukosavic S, Jackson-Lewis V, Neystat M, Jakowec M, Przedborski S. PMID: 10646524.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    67. Experimental models of Parkinson's disease: insights from many models. Lab Anim Sci. 1999 Aug; 49(4):363-71. Tolwani RJ, Jakowec MW, Petzinger GM, Green S, Waggie K. PMID: 10480640.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    68. The native form of alpha-synuclein is not found in the cerebrospinal fluid of patients with Parkinson's disease or normal controls. Neurosci Lett. 1998 Aug 28; 253(1):13-6. Jakowec MW, Petzinger GM, Sastry S, Donaldson DM, McCormack A, Langston JW. PMID: 9754793.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    69. The postnatal development of AMPA receptor subunits in the basal ganglia of the rat. Dev Neurosci. 1998; 20(1):19-33. Jakowec MW, Jackson-Lewis V, Chen X, Langston JW, Przedborski S. PMID: 9600387.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    70. Role of nitric oxide in methamphetamine neurotoxicity: protection by 7-nitroindazole, an inhibitor of neuronal nitric oxide synthase. J Neurochem. 1996 Dec; 67(6):2443-50. Di Monte DA, Royland JE, Jakowec MW, Langston JW. PMID: 8931477.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    71. Monoamine oxidase-dependent metabolism of dopamine in the striatum and substantia nigra of L-DOPA-treated monkeys. Brain Res. 1996 Oct 28; 738(1):53-9. Di Monte DA, DeLanney LE, Irwin I, Royland JE, Chan P, Jakowec MW, Langston JW. PMID: 8949927.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    72. Brain superoxide dismutase, catalase, and glutathione peroxidase activities in amyotrophic lateral sclerosis. Ann Neurol. 1996 Feb; 39(2):158-65. Przedborski S, Donaldson D, Jakowec M, Kish SJ, Guttman M, Rosoklija G, Hays AP. PMID: 8967746.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    73. Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neurodegeneration. 1995 Sep; 4(3):257-69. Jackson-Lewis V, Jakowec M, Burke RE, Przedborski S. PMID: 8581558.
      View in: PubMed   Mentions: 186     Fields:    Translation:AnimalsCells
    74. In situ hybridization analysis of AMPA receptor subunit gene expression in the developing rat spinal cord. Neuroscience. 1995 Aug; 67(4):909-20. Jakowec MW, Yen L, Kalb RG. PMID: 7675213.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    75. Quantitative and qualitative changes in AMPA receptor expression during spinal cord development. Neuroscience. 1995 Aug; 67(4):893-907. Jakowec MW, Fox AJ, Martin LJ, Kalb RG. PMID: 7675212.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    76. Mutational analysis of the open reading frames in the transposable element IS1. Genetics. 1988 Sep; 120(1):47-55. Jakowec M, Prentki P, Chandler M, Galas DJ. PMID: 2851480; PMCID: PMC1203504.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    77. Expression of proteins essential for IS1 transposition: specific binding of InsA to the ends of IS1. EMBO J. 1987 Oct; 6(10):3163-9. Zerbib D, Jakowec M, Prentki P, Galas DJ, Chandler M. PMID: 2826132; PMCID: PMC553758.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    78. Recombinant plasmid conferring proline overproduction and osmotic tolerance. Appl Environ Microbiol. 1985 Aug; 50(2):441-6. Jakowec MW, Smith LT, Dandekar AM. PMID: 2996423; PMCID: PMC238640.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
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