Liana Asatryan, PhD

Title(s)Assistant Professor of Clinical Pharmacy (Teaching Track)
SchoolUSC School of Pharmacy
AddressPSC 500A
Health Sciences Campus
Los Angeles CA 90089-9121
Phone+1 323 442 1495
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    Collapse Overview
    Dr. Liana Asatryan earned her PhD in Biochemistry from the Institute of Molecular Biology, National Academy of Sciences of Armenia. Dr. Asatryan has also completed the Graduate Certificate in Clinical Research Design & Management in Regulatory Science at USC. Currently, she a Research Assistant Professor in the Titus Family Department of Clinical Pharmacy at the USC School of Pharmacy. Dr. Asatryan currently lectures in the Pharmacology and Drug Development Undergraduate Program and Masters of Management of Drug Development at the Regulatory Science, USC.

    Research Interests: Understanding mechanisms of neuro-immune communication and their role in the development of alcohol use disorder (AUD) and other neurological disorders as well as alcohol liver disease. Identification of novel targets for therapeutic strategies to prevent or treat AUD-related inflammation and neuroinflammation. Work in this direction focuses on ligand-gate ion channel, implicated in neuroinflammation and neurodegeneration. The recent development in neuro-immune interactions lies in gut-immune-brain axis communication with a focus on the role of microbiome in AUD and alcoholic liver disease.

    Ongoing research projects include:
    • Identification of causal relationship between gut microbiome and development of
    neurological conditions including AUD, as well as alcoholic liver disease.
    • Targeting purinergic P2X7 receptors for conferring inflammation in brain and
    liver induced by chronic alcohol exposure
    • Screening of drug candidate for activities in brain receptors to treat mild
    cognitive impairment and Alzheimer’s Disease.

    Collapse Research 
    Collapse Research Activities and Funding
    Alcohol and Host Microbiome Interactions in Alcohol Consumption Behavior
    Rose Hills Foundation Innovator Grant Jul 1, 2019 - Jun 30, 2021
    Role: Principal Investigator
    The Role of P2X7 Receptors in Alcohol-induced Neuroinflammation and Degeneration
    Zumberge Fund Individual Grant Jul 1, 2014 - Jun 30, 2015
    Role: Principal Investigator
    Sites of Ethanol Action in Purinergic P2X4 Receptors
    NIH K01AA017243Sep 20, 2008 - Aug 31, 2013
    Role: Principal Investigator
    MEMBRANE LIPID REMODELING FOLLOWING OXIDATIVE STRESS
    NIH F05TW005340May 12, 1998
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dihydromyricetin supplementation improves ethanol-induced lipid accumulation and inflammation. Front Nutr. 2023; 10:1201007. Janilkarn-Urena I, Idrissova A, Zhang M, VanDreal M, Sanghavi N, Skinner SG, Cheng S, Zhang Z, Watanabe J, Asatryan L, Cadenas E, Davies DL. PMID: 37680900; PMCID: PMC10481966.
      View in: PubMed   Mentions:
    2. Sodium Butyrate Supplementation Modulates Neuroinflammatory Response Aggravated by Antibiotic Treatment in a Mouse Model of Binge-like Ethanol Drinking. Int J Mol Sci. 2022 Dec 10; 23(24). Gao L, Davies DL, Asatryan L. PMID: 36555338; PMCID: PMC9778941.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    3. Supplementation with sodium butyrate protects against antibiotic-induced increases in ethanol consumption behavior in mice. Alcohol. 2022 05; 100:1-9. Reyes RE, Gao L, Zhang Z, Davies DL, Asatryan L. PMID: 34999234; PMCID: PMC8983552.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    4. Cross-Talk between P2X and NMDA Receptors. Int J Mol Sci. 2020 Sep 29; 21(19). Rodriguez L, Yi C, Chu C, Duriez Q, Watanabe S, Ryu M, Reyes B, Asatryan L, Boué-Grabot E, Davies D. PMID: 33003406; PMCID: PMC7582700.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    5. Antibiotic-induced disruption of commensal microbiome linked to increases in binge-like ethanol consumption behavior. Brain Res. 2020 11 15; 1747:147067. Reyes REN, Al Omran AJ, Davies DL, Asatryan L. PMID: 32827548; PMCID: PMC8480222.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    6. A novel pharmacotherapy approach using P-glycoprotein (PGP/ABCB1) efflux inhibitor combined with ivermectin to reduce alcohol drinking and preference in mice. Alcohol. 2020 08; 86:1-8. Silva J, Khoja S, Asatryan L, Pacifici E, Davies DL. PMID: 32278067; PMCID: PMC7292774.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    7. Residues in Transmembrane Segments of the P2X4 Receptor Contribute to Channel Function and Ethanol Sensitivity. Int J Mol Sci. 2020 Apr 02; 21(7). Popova M, Rodriguez L, Trudell JR, Nguyen S, Bloomfield M, Davies DL, Asatryan L. PMID: 32252459; PMCID: PMC7178174.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    8. Dopamine Receptor Blockade Attenuates Purinergic P2X4 Receptor-Mediated Prepulse Inhibition Deficits and Underlying Molecular Mechanisms. Front Cell Neurosci. 2019; 13:331. Khoja S, Asatryan L, Jakowec MW, Davies DL. PMID: 31396053; PMCID: PMC6664007.
      View in: PubMed   Mentions: 7  
    9. Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice. J Vis Exp. 2019 01 07; (143). Huynh N, Arabian NM, Asatryan L, Davies DL. PMID: 30663649; PMCID: PMC6524528.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    10. Similarities in Blood Mononuclear Cell Membrane Phospholipid Profiles During Malignancy. Med Sci (Basel). 2018 Nov 23; 6(4). Hakobyan G, Davtyan H, Harutyunyan K, Alexanyan K, Amirkhanyan Y, Gharibyan AL, Asatryan L, Tadevosyan Y. PMID: 30477187; PMCID: PMC6313534.
      View in: PubMed   Mentions:    Fields:    
    11. P2X7 Receptor Antagonist A804598 Inhibits Inflammation in Brain and Liver in C57BL/6J Mice Exposed to Chronic Ethanol and High Fat Diet. J Neuroimmune Pharmacol. 2019 06; 14(2):263-277. Freire D, Reyes RE, Baghram A, Davies DL, Asatryan L. PMID: 30353422; PMCID: PMC6494709.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    12. Preclinical evaluation of avermectins as novel therapeutic agents for alcohol use disorders. Psychopharmacology (Berl). 2018 06; 235(6):1697-1709. Khoja S, Huynh N, Warnecke AMP, Asatryan L, Jakowec MW, Davies DL. PMID: 29500584; PMCID: PMC5949264.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    13. Reduced expression of purinergic P2X4 receptors increases voluntary ethanol intake in C57BL/6J mice. Alcohol. 2018 05; 68:63-70. Khoja S, Huynh N, Asatryan L, Jakowec MW, Davies DL. PMID: 29477921; PMCID: PMC5878121.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    14. Ethanol differentially modulates P2X4 and P2X7 receptor activity and function in BV2 microglial cells. Neuropharmacology. 2018 Jan; 128:11-21. Asatryan L, Ostrovskaya O, Lieu D, Davies DL. PMID: 28943285; PMCID: PMC6492934.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    15. Preclinical development of moxidectin as a novel therapeutic for alcohol use disorder. Neuropharmacology. 2017 02; 113(Pt A):60-70. Huynh N, Arabian N, Naito A, Louie S, Jakowec MW, Asatryan L, Davies DL. PMID: 27641072; PMCID: PMC5148646.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    16. Role of purinergic P2X4 receptors in regulating striatal dopamine homeostasis and dependent behaviors. J Neurochem. 2016 10; 139(1):134-48. Khoja S, Shah V, Garcia D, Asatryan L, Jakowec MW, Davies DL. PMID: 27402173; PMCID: PMC5037001.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    17. Utilizing an Orally Dissolving Strip for Pharmacological and Toxicological Studies: A Simple and Humane Alternative to Oral Gavage for Animals. J Vis Exp. 2016 Mar 23; (109):e53770. Huynh N, Arabian N, Lieu D, Asatryan L, Davies DL. PMID: 27078261; PMCID: PMC4841306.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    18. Epigenetic control of group V phospholipase A2 expression in human malignant cells. Tumour Biol. 2016 Jun; 37(6):8097-105. Menschikowski M, Hagelgans A, Nacke B, Jandeck C, Mareninova OA, Asatryan L, Siegert G. PMID: 26715269.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    19. Chronic ethanol exposure combined with high fat diet up-regulates P2X7 receptors that parallels neuroinflammation and neuronal loss in C57BL/6J mice. J Neuroimmunol. 2015 Aug 15; 285:169-79. Asatryan L, Khoja S, Rodgers KE, Alkana RL, Tsukamoto H, Davies DL. PMID: 26198936; PMCID: PMC4512299.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    20. Manipulations of extracellular Loop 2 in α1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofol. Neuroscience. 2015 Jun 25; 297:68-77. Naito A, Muchhala KH, Trang J, Asatryan L, Trudell JR, Homanics GE, Alkana RL, Davies DL. PMID: 25827497; PMCID: PMC4428915.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    21. Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research. Mol Pharmacol. 2014 Dec; 86(6):635-46. Naito A, Muchhala KH, Asatryan L, Trudell JR, Homanics GE, Perkins DI, Davies DL, Alkana RL. PMID: 25245406; PMCID: PMC4244596.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    22. Multiday administration of ivermectin is effective in reducing alcohol intake in mice at doses shown to be safe in humans. Neuroreport. 2014 Sep 10; 25(13):1018-23. Yardley MM, Neely M, Huynh N, Asatryan L, Louie SG, Alkana RL, Davies DL. PMID: 25004078; PMCID: PMC4126080.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    23. P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disorders. Front Neurosci. 2014; 8:176. Franklin KM, Asatryan L, Jakowec MW, Trudell JR, Bell RL, Davies DL. PMID: 25009459; PMCID: PMC4068020.
      View in: PubMed   Mentions: 35  
    24. Contribution of P2X4 receptors to ethanol intake in male C57BL/6 mice. Neurochem Res. 2014 Jun; 39(6):1127-39. Wyatt LR, Finn DA, Khoja S, Yardley MM, Asatryan L, Alkana RL, Davies DL. PMID: 24671605; PMCID: PMC4031031.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    25. Avermectins differentially affect ethanol intake and receptor function: implications for developing new therapeutics for alcohol use disorders. Int J Neuropsychopharmacol. 2014 Jun; 17(6):907-16. Asatryan L, Yardley MM, Khoja S, Trudell JR, Hyunh N, Louie SG, Petasis NA, Alkana RL, Davies DL. PMID: 24451653; PMCID: PMC4209915.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    26. Serum amyloid A, phospholipase A₂-IIA and C-reactive protein as inflammatory biomarkers for prostate diseases. Inflamm Res. 2013 Dec; 62(12):1063-72. Menschikowski M, Hagelgans A, Fuessel S, Mareninova OA, Asatryan L, Wirth MP, Siegert G. PMID: 24061501.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    27. Tryptophan 46 is a site for ethanol and ivermectin action in P2X4 receptors. Purinergic Signal. 2013 Dec; 9(4):621-32. Popova M, Trudell J, Li K, Alkana R, Davies D, Asatryan L. PMID: 23817978; PMCID: PMC3889384.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    28. Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin. Int J Neuropsychopharmacol. 2013 Jun; 16(5):1059-70. Bortolato M, Yardley MM, Khoja S, Godar SC, Asatryan L, Finn DA, Alkana RL, Louie SG, Davies DL. PMID: 23174033; PMCID: PMC3593990.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    29. Ivermectin reduces alcohol intake and preference in mice. Neuropharmacology. 2012 Aug; 63(2):190-201. Yardley MM, Wyatt L, Khoja S, Asatryan L, Ramaker MJ, Finn DA, Alkana RL, Huynh N, Louie SG, Petasis NA, Bortolato M, Davies DL. PMID: 22465817; PMCID: PMC3372603.
      View in: PubMed   Mentions: 40     Fields:    Translation:Animals
    30. Charge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptors. J Pharmacol Exp Ther. 2012 May; 341(2):543-51. Perkins DI, Trudell JR, Asatryan L, Davies DL, Alkana RL. PMID: 22357974; PMCID: PMC3336819.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    31. Implication of the purinergic system in alcohol use disorders. Alcohol Clin Exp Res. 2011 Apr; 35(4):584-94. Asatryan L, Nam HW, Lee MR, Thakkar MM, Saeed Dar M, Davies DL, Choi DS. PMID: 21223299; PMCID: PMC3076125.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    32. Ethanol is a fast channel inhibitor of P2X4 receptors. J Pharmacol Exp Ther. 2011 Apr; 337(1):171-9. Ostrovskaya O, Asatryan L, Wyatt L, Popova M, Li K, Peoples RW, Alkana RL, Davies DL. PMID: 21212160; PMCID: PMC3063738.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    33. Ivermectin antagonizes ethanol inhibition in purinergic P2X4 receptors. J Pharmacol Exp Ther. 2010 Sep 01; 334(3):720-8. Asatryan L, Popova M, Perkins D, Trudell JR, Alkana RL, Davies DL. PMID: 20543096; PMCID: PMC2939657.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    34. A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors. J Neurochem. 2010 Jan; 112(1):307-17. Popova M, Asatryan L, Ostrovskaya O, Wyatt LR, Li K, Alkana RL, Davies DL. PMID: 19878433; PMCID: PMC2809143.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    35. Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity. J Biol Chem. 2009 Oct 02; 284(40):27304-14. Perkins DI, Trudell JR, Crawford DK, Asatryan L, Alkana RL, Davies DL. PMID: 19656948; PMCID: PMC2785658.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    36. LDL protein nitration: implication for LDL protein unfolding. Arch Biochem Biophys. 2008 Nov 01; 479(1):1-14. Hamilton RT, Asatryan L, Nilsen JT, Isas JM, Gallaher TK, Sawamura T, Hsiai TK. PMID: 18713619; PMCID: PMC2649963.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    37. Roles of ectodomain and transmembrane regions in ethanol and agonist action in purinergic P2X2 and P2X3 receptors. Neuropharmacology. 2008 Oct; 55(5):835-43. Asatryan L, Popova M, Woodward JJ, King BF, Alkana RL, Davies DL. PMID: 18639563; PMCID: PMC2629788.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    38. Effects of ethanol on adenosine 5'-triphosphate-gated purinergic and 5-hydroxytryptamine receptors. Alcohol Clin Exp Res. 2006 Feb; 30(2):349-58. Davies DL, Asatryan L, Kuo ST, Woodward JJ, King BF, Alkana RL, Xiao C, Ye JH, Sun H, Zhang L, Hu XQ, Hayrapetyan V, Lovinger DM, Machu TK. PMID: 16441284; PMCID: PMC1448702.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    39. High-density lipoprotein hydrolysis by endothelial lipase activates PPARalpha: a candidate mechanism for high-density lipoprotein-mediated repression of leukocyte adhesion. Circ Res. 2006 Mar 03; 98(4):490-8. Ahmed W, Orasanu G, Nehra V, Asatryan L, Rader DJ, Ziouzenkova O, Plutzky J. PMID: 16439686; PMCID: PMC4231787.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    40. Role of annexin II in estrogen-induced macrophage matrix metalloproteinase-9 activity: the modulating effect of statins. Atherosclerosis. 2006 Nov; 189(1):76-82. Hwang J, Hodis HN, Hsiai TK, Asatryan L, Sevanian A. PMID: 16386257.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    41. LDL phospholipid hydrolysis produces modified electronegative particles with an unfolded apoB-100 protein. J Lipid Res. 2005 Jan; 46(1):115-22. Asatryan L, Hamilton RT, Isas JM, Hwang J, Kayed R, Sevanian A. PMID: 15489541; PMCID: PMC3383313.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    42. Dual roles for lipolysis and oxidation in peroxisome proliferation-activator receptor responses to electronegative low density lipoprotein. J Biol Chem. 2003 Oct 10; 278(41):39874-81. Ziouzenkova O, Asatryan L, Sahady D, Orasanu G, Perrey S, Cutak B, Hassell T, Akiyama TE, Berger JP, Sevanian A, Plutzky J. PMID: 12878589; PMCID: PMC4231711.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    43. Heme and lipid peroxides in hemoglobin-modified low-density lipoprotein mediate cell survival and adaptation to oxidative stress. Blood. 2003 Sep 01; 102(5):1732-9. Asatryan L, Ziouzenkova O, Duncan R, Sevanian A. PMID: 12750169.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    44. Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2730-5. Ziouzenkova O, Perrey S, Asatryan L, Hwang J, MacNaul KL, Moller DE, Rader DJ, Sevanian A, Zechner R, Hoefler G, Plutzky J. PMID: 12606719; PMCID: PMC151409.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    45. Oxidative stress during ex vivo hemodialysis of blood is decreased by a novel hemolipodialysis procedure utilizing antioxidants. Free Radic Biol Med. 2002 Jul 15; 33(2):248-58. Ziouzenkova O, Asatryan L, Tetta C, Wratten ML, Hwang J, Sevanian A. PMID: 12106820.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    46. LDL modification during hemodialysis. Markers for oxidative stress. Contrib Nephrol. 2002; (137):386-95. Sevanian A, Asatryan L. PMID: 12101983.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    47. Oxidative cross-linking of ApoB100 and hemoglobin results in low density lipoprotein modification in blood. Relevance to atherogenesis caused by hemodialysis. J Biol Chem. 1999 Jul 02; 274(27):18916-24. Ziouzenkova O, Asatryan L, Akmal M, Tetta C, Wratten ML, Loseto-Wich G, Jürgens G, Heinecke J, Sevanian A. PMID: 10383389.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    48. Oxidative stress resulting from hemolysis and formation of catalytically active hemoglobin: protective strategies. Int J Clin Pharmacol Ther. 1999 Mar; 37(3):125-32. Ziouzenkova O, Asatryan L, Sevanian A. PMID: 10190760.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    49. Low density lipoprotein (LDL) modification: basic concepts and relationship to atherosclerosis. Blood Purif. 1999; 17(2-3):66-78. Sevanian A, Asatryan L, Ziouzenkova O. PMID: 10449864.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    50. The effect of ribosomal peptidyl-transferase inhibitors is antagonized by elongation factor G with GTP. FEBS Lett. 1976 Nov; 70(1):101-4. Spirin AS, Asatryan LS. PMID: 791676.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    51. Non-enzymatic translocation in ribosomes from streptomycin-resistant mutants of Escherichia coli. Mol Gen Genet. 1975 Jul 10; 138(4):315-21. Asatryan LS, Spirin AS. PMID: 1097889.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
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