Roger F Duncan, PhD

TitleAssociate Professor
InstitutionUniversity of Southern California
DepartmentPharmacology and Pharmaceutical Sciences
AddressPSC 210A
Health Sciences Campus
Los Angeles CA 90089-9121
Phone+1 323 442 1449
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    Collapse Overview
    Dr. Duncan received his Ph.D. from the University of Hawaii in 1978. He moved to the University of Colorado (Boulder) and the University of California (Davis) for post-doctoral research studies, before joining the University of Southern California School of Pharmacy in 1987, where he is currently an associate professor in the Department of Molecular Pharmacology.

    Collapse Research 
    Collapse Research Activities and Funding
    NIH/NIGMS R29GM042644Jul 1, 1989 - Jun 30, 1994
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Xu S, Butkevich AN, Yamada R, Zhou Y, Debnath B, Duncan R, Zandi E, Petasis NA, Neamati N. Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16348-53. PMID: 22988091; PMCID: PMC3479552.
    2. Duncan R. Rapamycin conditionally inhibits Hsp90 but not Hsp70 mRNA translation in Drosophila: implications for the mechanisms of Hsp mRNA translation. Cell Stress Chaperones. 2008; 13(2):143-55. PMID: 18418733; PMCID: PMC2673887.
    3. Duncan R. Inhibition of Hsp90 function delays and impairs recovery from heat shock. FEBS J. 2005 Oct; 272(20):5244-56. PMID: 16218955.
      View in: PubMed
    4. Duncan R, Peterson H, Sevanian A. Signal transduction pathways leading to increased eIF4E phosphorylation caused by oxidative stress. Free Radic Biol Med. 2005 Mar 01; 38(5):631-43. PMID: 15683719.
      View in: PubMed
    5. Ahmed R, Duncan R. Translational regulation of Hsp90 mRNA. AUG-proximal 5'-untranslated region elements essential for preferential heat shock translation. J Biol Chem. 2004 Nov 26; 279(48):49919-30. PMID: 15347681.
      View in: PubMed
    6. Schroeter H, Boyd CS, Ahmed R, Spencer JP, Duncan R, Rice-Evans C, Cadenas E. c-Jun N-terminal kinase (JNK)-mediated modulation of brain mitochondria function: new target proteins for JNK signalling in mitochondrion-dependent apoptosis. Biochem J. 2003 Jun 01; 372(Pt 2):359-69. PMID: 12614194; PMCID: PMC1223409.
    7. Asatryan L, Ziouzenkova O, Duncan R, Sevanian A. Heme and lipid peroxides in hemoglobin-modified low-density lipoprotein mediate cell survival and adaptation to oxidative stress. Blood. 2003 Sep 01; 102(5):1732-9. PMID: 12750169.
      View in: PubMed
    8. Duncan R, Peterson H, Hagedorn CH, Sevanian A. Oxidative stress increases eukaryotic initiation factor 4E phosphorylation in vascular cells. Biochem J. 2003 Jan 15; 369(Pt 2):213-25. PMID: 12215171; PMCID: PMC1223074.
    9. Koev G, Duncan R, Lai MM. Hepatitis C virus IRES-dependent translation is insensitive to an eIF2alpha-independent mechanism of inhibition by interferon in hepatocyte cell lines. Virology. 2002 Jun 05; 297(2):195-202. PMID: 12083818.
      View in: PubMed