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Roger F Duncan, PhD

TitleAssociate Professor
InstitutionUniversity of Southern California
DepartmentPharmacology and Pharmaceutical Sciences
AddressPSC 210A
Health Sciences Campus
Los Angeles CA 90089-9121
Phone+1 323 442 1449
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    Collapse Overview
    Dr. Duncan received his Ph.D. from the University of Hawaii in 1978. He moved to the University of Colorado (Boulder) and the University of California (Davis) for post-doctoral research studies, before joining the University of Southern California School of Pharmacy in 1987, where he is currently an associate professor in the Department of Molecular Pharmacology.


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    HEAT STRESS EFFECTS ON PROTEIN SYNTHESIS
    NIH/NIGMS R29GM042644Jul 1, 1989 - Jun 30, 1994
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Xu S, Butkevich AN, Yamada R, Zhou Y, Debnath B, Duncan R, Zandi E, Petasis NA, Neamati N. Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16348-53. PMID: 22988091; PMCID: PMC3479552.
    2. Duncan R. Rapamycin conditionally inhibits Hsp90 but not Hsp70 mRNA translation in Drosophila: implications for the mechanisms of Hsp mRNA translation. Cell Stress Chaperones. 2008; 13(2):143-55. PMID: 18418733; PMCID: PMC2673887.
    3. Duncan R. Inhibition of Hsp90 function delays and impairs recovery from heat shock. FEBS J. 2005 Oct; 272(20):5244-56. PMID: 16218955.
      View in: PubMed
    4. Duncan R, Peterson H, Sevanian A. Signal transduction pathways leading to increased eIF4E phosphorylation caused by oxidative stress. Free Radic Biol Med. 2005 Mar 01; 38(5):631-43. PMID: 15683719.
      View in: PubMed
    5. Ahmed R, Duncan R. Translational regulation of Hsp90 mRNA. AUG-proximal 5'-untranslated region elements essential for preferential heat shock translation. J Biol Chem. 2004 Nov 26; 279(48):49919-30. PMID: 15347681.
      View in: PubMed
    6. Schroeter H, Boyd CS, Ahmed R, Spencer JP, Duncan R, Rice-Evans C, Cadenas E. c-Jun N-terminal kinase (JNK)-mediated modulation of brain mitochondria function: new target proteins for JNK signalling in mitochondrion-dependent apoptosis. Biochem J. 2003 Jun 01; 372(Pt 2):359-69. PMID: 12614194; PMCID: PMC1223409.
    7. Asatryan L, Ziouzenkova O, Duncan R, Sevanian A. Heme and lipid peroxides in hemoglobin-modified low-density lipoprotein mediate cell survival and adaptation to oxidative stress. Blood. 2003 Sep 01; 102(5):1732-9. PMID: 12750169.
      View in: PubMed
    8. Duncan R, Peterson H, Hagedorn CH, Sevanian A. Oxidative stress increases eukaryotic initiation factor 4E phosphorylation in vascular cells. Biochem J. 2003 Jan 15; 369(Pt 2):213-25. PMID: 12215171; PMCID: PMC1223074.
    9. Koev G, Duncan R, Lai MM. Hepatitis C virus IRES-dependent translation is insensitive to an eIF2alpha-independent mechanism of inhibition by interferon in hepatocyte cell lines. Virology. 2002 Jun 05; 297(2):195-202. PMID: 12083818.
      View in: PubMed