Daryl L Davies, PhD

Title(s)Associate Dean of Undergraduate Education and Professor of Clinical Pharmacy
SchoolUSC School of Pharmacy
AddressPSC 528
Health Sciences Campus
Los Angeles CA 90089-9121
Phone+1 323 442 1427
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    Daryl L. Davies, PhD, Professor of Clinical Pharmacy, Titus Family Department of Clinical Pharmacy, University of Southern California. In addition, he is the Director of the MS program in Management of Drug Development, in the International Center of Regulatory Science located in the School of Pharmacy. Dr. Davies earned his Bachelor and Master Degrees in Biology at California State University, Dominguez Hills. He earned his PhD in 1996 from the Department of Molecular Pharmacology and Toxicology at USC School of Pharmacy.
    Dr. Davies is the director of the Alcohol and Brain Research Laboratory at USC. His research revolves around the development of novel treatments for alcohol use disorders (AUDs). AUDs ranks third on the list of preventable causes of morbidity and mortality in the United States, having a major national impact affecting over 18 million people and causing over 100,000 deaths annually. The economic burden to society for AUDs is in excess of $220 billion annually which exceeds the costs of other leading preventable causes of death such as cigarette smoking and physical inactivity. Presently, pharmacotherapies, even in conjunction with psychosocial strategies, have had limited success in treating AUDs with approximately 70% of patients relapsing back into heavy drinking within one year. Finally, drug development for AUDs is a relatively young field compared to other diseases such as cancer, cardiovascular and psychiatric disorders. Therefore, the development of new treatments for AUDs represents an important unmet medical need.
    In response to this challenge, Dr. Davies and his team have focused on identifying molecular targets of alcohol action in the CNS. Recent findings from this line of investigation have resulted in the identification of specific targets for which therapeutic compounds have been designed and are currently under investigation. This multidisciplinary endeavor has brought together diverse but complementary group of scientists which include behavioral, pharmacological, electrophysiological, molecular, genetic, computational and medicinal chemistry expertise’s to maximize the potential for success. This team includes Drs. Ronald Alkana and Stan Louie (School of Pharmacy), Dr. Michael Neely (Keck School of Medicine), Dr. Nicos Petasis (Dornsife College LAS), Dr. Debra Finn (Oregon Health & Science University), and Dr. James Trudell (Stanford).

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Alcohol Intake by Purinergic P2X4 Receptors
    NIH R01AA022448Sep 1, 2013 - Jun 30, 2021
    Role: Principal Investigator
    Sites and Mechanisms of Ethanol Action in P2X receptors
    NIH R01AA013922Aug 15, 2004 - May 31, 2010
    Role: Principal Investigator
    Pressure-Based Pharmacological Alcoholism Treatments
    NIH R21AA013890May 1, 2003 - Apr 30, 2008
    Role: Principal Investigator
    NIH F31AA005436Mar 27, 1996
    Role: Principal Investigator

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    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Association of over the counter "hangover remedy" use with alcohol use problems and consumption patterns among young adults. Alcohol Alcohol. 2024 Jan 17; 59(2). Han DH, Davis JP, Davies DL, Clapp JD, Pedersen ER, Leventhal AM. PMID: 38016799; PMCID: PMC10794163.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Dihydromyricetin supplementation improves ethanol-induced lipid accumulation and inflammation. Front Nutr. 2023; 10:1201007. Janilkarn-Urena I, Idrissova A, Zhang M, VanDreal M, Sanghavi N, Skinner SG, Cheng S, Zhang Z, Watanabe J, Asatryan L, Cadenas E, Davies DL. PMID: 37680900; PMCID: PMC10481966.
      View in: PubMed   Mentions:
    3. Improving the solubility of pseudo-hydrophobic Alzheimer's Disease medicinal chemicals through co-crystal formulation. bioRxiv. 2023 Apr 28. Tse A, Janilkarn-Urena I, Lin J, Chang X, Efthymiou C, Idrissova A, Zhang M, Williams CK, Magaki S, Vinters HV, Davies DL, Gonen T, Gukasyan HJ, Seidler PM. PMID: 37162961; PMCID: PMC10168350.
      View in: PubMed   Mentions:
    4. Pharmacy undergraduate programs: Development of an adaptive curriculum for student success. Heliyon. 2023 Feb; 9(2):e13437. Church TD, Burkhardt AM, Phan T, Davies DL. PMID: 36814624; PMCID: PMC9939604.
      View in: PubMed   Mentions:
    5. Sodium Butyrate Supplementation Modulates Neuroinflammatory Response Aggravated by Antibiotic Treatment in a Mouse Model of Binge-like Ethanol Drinking. Int J Mol Sci. 2022 Dec 10; 23(24). Gao L, Davies DL, Asatryan L. PMID: 36555338; PMCID: PMC9778941.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    6. Dihydromyricetin improves social isolation-induced cognitive impairments and astrocytic changes in mice. Sci Rep. 2022 04 07; 12(1):5899. Watanabe S, Omran AA, Shao AS, Xue C, Zhang Z, Zhang J, Davies DL, Shao XM, Watanabe J, Liang J. PMID: 35393483; PMCID: PMC8989100.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    7. Supplementation with sodium butyrate protects against antibiotic-induced increases in ethanol consumption behavior in mice. Alcohol. 2022 05; 100:1-9. Reyes RE, Gao L, Zhang Z, Davies DL, Asatryan L. PMID: 34999234; PMCID: PMC8983552.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    8. Social isolation induces neuroinflammation and microglia overactivation, while dihydromyricetin prevents and improves them. J Neuroinflammation. 2022 Jan 04; 19(1):2. Al Omran AJ, Shao AS, Watanabe S, Zhang Z, Zhang J, Xue C, Watanabe J, Davies DL, Shao XM, Liang J. PMID: 34983568; PMCID: PMC8724741.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    9. Social Isolation Induces Neuroinflammation And Microglia Overactivation, While Dihydromyricetin Prevents And Improves Them. Res Sq. 2021 Oct 01. Al Omran AJ, Shao AS, Watanabe S, Zhang Z, Zhang J, Xue C, Watanabe J, Davies DL, Shao XM, Liang J. PMID: 34611661; PMCID: PMC8491854.
      View in: PubMed   Mentions:
    10. The P2X4 purinergic receptor has emerged as a potent regulator of hematopoietic stem/progenitor cell mobilization and homing-a novel view of P2X4 and P2X7 receptor interaction in orchestrating stem cell trafficking. Leukemia. 2022 01; 36(1):248-256. Adamiak M, Bujko K, Thapa A, Pensato V, Brzezniakiewicz-Janus K, Ratajczak J, Davies DL, Ulrich H, Kucia M, Ratajczak MZ. PMID: 34285343.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    11. Identification of Dihydromyricetin and Metabolites in Serum and Brain Associated with Acute Anti-Ethanol Intoxicating Effects in Mice. Int J Mol Sci. 2021 Jul 12; 22(14). Carry E, Kshatriya D, Silva J, Davies DL, Yuan B, Wu Q, Patel H, Park ER, Gilleran J, Hao L, Roberge J, Bello NT, Simon JE. PMID: 34299083; PMCID: PMC8307506.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    12. A Novel Dual Drug Approach That Combines Ivermectin and Dihydromyricetin (DHM) to Reduce Alcohol Drinking and Preference in Mice. Molecules. 2021 Mar 22; 26(6). Silva J, Carry E, Xue C, Zhang J, Liang J, Roberge JY, Davies DL. PMID: 33810134; PMCID: PMC8004700.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    13. Dihydromyricetin improves mitochondrial outcomes in the liver of alcohol-fed mice via the AMPK/Sirt-1/PGC-1α signaling axis. Alcohol. 2021 03; 91:1-9. Silva J, Spatz MH, Folk C, Chang A, Cadenas E, Liang J, Davies DL. PMID: 33080338; PMCID: PMC7902334.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    14. Cross-Talk between P2X and NMDA Receptors. Int J Mol Sci. 2020 Sep 29; 21(19). Rodriguez L, Yi C, Chu C, Duriez Q, Watanabe S, Ryu M, Reyes B, Asatryan L, Boué-Grabot E, Davies D. PMID: 33003406; PMCID: PMC7582700.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    15. Antibiotic-induced disruption of commensal microbiome linked to increases in binge-like ethanol consumption behavior. Brain Res. 2020 11 15; 1747:147067. Reyes REN, Al Omran AJ, Davies DL, Asatryan L. PMID: 32827548; PMCID: PMC8480222.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    16. Ethanol antagonizes P2X4 receptors in ventral tegmental area neurons. Neuroreport. 2020 08 12; 31(12):936-941. Rodriguez L, You C, Brodie MS, Davies DL. PMID: 32658126; PMCID: PMC7425777.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    17. The macrocyclic lactones ivermectin and moxidectin show differential effects on rotational behavior in the 6-hydroxydopamine mouse model of Parkinson's disease. Behav Brain Res. 2020 09 01; 393:112804. Warnecke AMP, Kang MS, Jakowec MW, Davies DL. PMID: 32668263.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    18. Modulation of Hippocampal GABAergic Neurotransmission and Gephyrin Levels by Dihydromyricetin Improves Anxiety. Front Pharmacol. 2020; 11:1008. Silva J, Shao AS, Shen Y, Davies DL, Olsen RW, Holschneider DP, Shao XM, Liang J. PMID: 32742262; PMCID: PMC7364153.
      View in: PubMed   Mentions: 6  
    19. Dihydromyricetin Protects the Liver via Changes in Lipid Metabolism and Enhanced Ethanol Metabolism. Alcohol Clin Exp Res. 2020 05; 44(5):1046-1060. Silva J, Yu X, Moradian R, Folk C, Spatz MH, Kim P, Bhatti AA, Davies DL, Liang J. PMID: 32267550; PMCID: PMC7211127.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    20. A novel pharmacotherapy approach using P-glycoprotein (PGP/ABCB1) efflux inhibitor combined with ivermectin to reduce alcohol drinking and preference in mice. Alcohol. 2020 08; 86:1-8. Silva J, Khoja S, Asatryan L, Pacifici E, Davies DL. PMID: 32278067; PMCID: PMC7292774.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    21. Residues in Transmembrane Segments of the P2X4 Receptor Contribute to Channel Function and Ethanol Sensitivity. Int J Mol Sci. 2020 Apr 02; 21(7). Popova M, Rodriguez L, Trudell JR, Nguyen S, Bloomfield M, Davies DL, Asatryan L. PMID: 32252459; PMCID: PMC7178174.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    22. Dopamine Receptor Blockade Attenuates Purinergic P2X4 Receptor-Mediated Prepulse Inhibition Deficits and Underlying Molecular Mechanisms. Front Cell Neurosci. 2019; 13:331. Khoja S, Asatryan L, Jakowec MW, Davies DL. PMID: 31396053; PMCID: PMC6664007.
      View in: PubMed   Mentions: 7  
    23. A newly developed anesthetic based on a unique chemical core. Proc Natl Acad Sci U S A. 2019 07 30; 116(31):15706-15715. Cayla NS, Dagne BA, Wu Y, Lu Y, Rodriguez L, Davies DL, Gross ER, Heifets BD, Davies MF, MacIver MB, Bertaccini EJ. PMID: 31308218; PMCID: PMC6681746.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    24. Moxidectin Effects on Gut Microbiota of Wistar-Kyoto Rats: Relevance to Depressive-Like Behavior. Clin Pharmacol Transl Med. 2019; 3(1):134-142. Getachew B, Reyes RE, Davies DL, Tizabi Y. PMID: 31321385; PMCID: PMC6639013.
      View in: PubMed   Mentions: 5  
    25. Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice. J Vis Exp. 2019 01 07; (143). Huynh N, Arabian NM, Asatryan L, Davies DL. PMID: 30663649; PMCID: PMC6524528.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    26. P2X7 Receptor Antagonist A804598 Inhibits Inflammation in Brain and Liver in C57BL/6J Mice Exposed to Chronic Ethanol and High Fat Diet. J Neuroimmune Pharmacol. 2019 06; 14(2):263-277. Freire D, Reyes RE, Baghram A, Davies DL, Asatryan L. PMID: 30353422; PMCID: PMC6494709.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    27. Macrophage P2X4 receptors augment bacterial killing and protect against sepsis. JCI Insight. 2018 06 07; 3(11). Csóka B, Németh ZH, Szabó I, Davies DL, Varga ZV, Pálóczi J, Falzoni S, Di Virgilio F, Muramatsu R, Yamashita T, Pacher P, Haskó G. PMID: 29875325; PMCID: PMC5997389.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    28. Preclinical evaluation of avermectins as novel therapeutic agents for alcohol use disorders. Psychopharmacology (Berl). 2018 06; 235(6):1697-1709. Khoja S, Huynh N, Warnecke AMP, Asatryan L, Jakowec MW, Davies DL. PMID: 29500584; PMCID: PMC5949264.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    29. Reduced expression of purinergic P2X4 receptors increases voluntary ethanol intake in C57BL/6J mice. Alcohol. 2018 05; 68:63-70. Khoja S, Huynh N, Asatryan L, Jakowec MW, Davies DL. PMID: 29477921; PMCID: PMC5878121.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    30. Ethanol differentially modulates P2X4 and P2X7 receptor activity and function in BV2 microglial cells. Neuropharmacology. 2018 Jan; 128:11-21. Asatryan L, Ostrovskaya O, Lieu D, Davies DL. PMID: 28943285; PMCID: PMC6492934.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    31. α2 Subunit-Containing GABAA Receptor Subtypes Are Upregulated and Contribute to Alcohol-Induced Functional Plasticity in the Rat Hippocampus. Mol Pharmacol. 2017 08; 92(2):101-112. Lindemeyer AK, Shen Y, Yazdani F, Shao XM, Spigelman I, Davies DL, Olsen RW, Liang J. PMID: 28536106; PMCID: PMC5508196.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    32. Preclinical development of moxidectin as a novel therapeutic for alcohol use disorder. Neuropharmacology. 2017 02; 113(Pt A):60-70. Huynh N, Arabian N, Naito A, Louie S, Jakowec MW, Asatryan L, Davies DL. PMID: 27641072; PMCID: PMC5148646.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    33. P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate Nucleus. J Neurosci. 2016 08 24; 36(34):8902-20. Xu J, Bernstein AM, Wong A, Lu XH, Khoja S, Yang XW, Davies DL, Micevych P, Sofroniew MV, Khakh BS. PMID: 27559172; PMCID: PMC4995303.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    34. Role of purinergic P2X4 receptors in regulating striatal dopamine homeostasis and dependent behaviors. J Neurochem. 2016 10; 139(1):134-48. Khoja S, Shah V, Garcia D, Asatryan L, Jakowec MW, Davies DL. PMID: 27402173; PMCID: PMC5037001.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    35. Sex and the Lab: An Alcohol-Focused Commentary on the NIH Initiative to Balance Sex in Cell and Animal Studies. Alcohol Clin Exp Res. 2016 06; 40(6):1182-91. Guizzetti M, Davies DL, Egli M, Finn DA, Molina P, Regunathan S, Robinson DL, Sohrabji F. PMID: 27154003; PMCID: PMC4889570.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    36. A Pilot Study of the Safety and Initial Efficacy of Ivermectin for the Treatment of Alcohol Use Disorder. Alcohol Clin Exp Res. 2016 06; 40(6):1312-20. Roche DJ, Yardley MM, Lunny KF, Louie SG, Davies DL, Miotto K, Ray LA. PMID: 27087145; PMCID: PMC4942320.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    37. Utilizing an Orally Dissolving Strip for Pharmacological and Toxicological Studies: A Simple and Humane Alternative to Oral Gavage for Animals. J Vis Exp. 2016 Mar 23; (109):e53770. Huynh N, Arabian N, Lieu D, Asatryan L, Davies DL. PMID: 27078261; PMCID: PMC4841306.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    38. Chronic ethanol exposure combined with high fat diet up-regulates P2X7 receptors that parallels neuroinflammation and neuronal loss in C57BL/6J mice. J Neuroimmunol. 2015 Aug 15; 285:169-79. Asatryan L, Khoja S, Rodgers KE, Alkana RL, Tsukamoto H, Davies DL. PMID: 26198936; PMCID: PMC4512299.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    39. Oral delivery of ivermectin using a fast dissolving oral film: Implications for repurposing ivermectin as a pharmacotherapy for alcohol use disorder. Alcohol. 2015 Sep; 49(6):553-9. Yardley MM, Huynh N, Rodgers KE, Alkana RL, Davies DL. PMID: 26095588; PMCID: PMC4554813.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    40. The importance of animals in advancing research on alcohol use disorders. Alcohol Clin Exp Res. 2015 Apr; 39(4):575-8. Helms CM, Bell RL, Bennett AJ, Davies DL, Chester JA, Kosten TA, Leeman RF, Panicker S, Platt DM, Weiner JL, Edwards S. PMID: 25833015; PMCID: PMC5052074.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    41. Manipulations of extracellular Loop 2 in α1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofol. Neuroscience. 2015 Jun 25; 297:68-77. Naito A, Muchhala KH, Trang J, Asatryan L, Trudell JR, Homanics GE, Alkana RL, Davies DL. PMID: 25827497; PMCID: PMC4428915.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    42. Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research. Mol Pharmacol. 2014 Dec; 86(6):635-46. Naito A, Muchhala KH, Asatryan L, Trudell JR, Homanics GE, Perkins DI, Davies DL, Alkana RL. PMID: 25245406; PMCID: PMC4244596.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    43. Multiday administration of ivermectin is effective in reducing alcohol intake in mice at doses shown to be safe in humans. Neuroreport. 2014 Sep 10; 25(13):1018-23. Yardley MM, Neely M, Huynh N, Asatryan L, Louie SG, Alkana RL, Davies DL. PMID: 25004078; PMCID: PMC4126080.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    44. P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disorders. Front Neurosci. 2014; 8:176. Franklin KM, Asatryan L, Jakowec MW, Trudell JR, Bell RL, Davies DL. PMID: 25009459; PMCID: PMC4068020.
      View in: PubMed   Mentions: 35  
    45. Contribution of P2X4 receptors to ethanol intake in male C57BL/6 mice. Neurochem Res. 2014 Jun; 39(6):1127-39. Wyatt LR, Finn DA, Khoja S, Yardley MM, Asatryan L, Alkana RL, Davies DL. PMID: 24671605; PMCID: PMC4031031.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    46. Avermectins differentially affect ethanol intake and receptor function: implications for developing new therapeutics for alcohol use disorders. Int J Neuropsychopharmacol. 2014 Jun; 17(6):907-16. Asatryan L, Yardley MM, Khoja S, Trudell JR, Hyunh N, Louie SG, Petasis NA, Alkana RL, Davies DL. PMID: 24451653; PMCID: PMC4209915.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    47. Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol. Alcohol Clin Exp Res. 2014 Mar; 38(3):595-603. Olsen RW, Li GD, Wallner M, Trudell JR, Bertaccini EJ, Lindahl E, Miller KW, Alkana RL, Davies DL. PMID: 24164436; PMCID: PMC3959612.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    48. Tryptophan 46 is a site for ethanol and ivermectin action in P2X4 receptors. Purinergic Signal. 2013 Dec; 9(4):621-32. Popova M, Trudell J, Li K, Alkana R, Davies D, Asatryan L. PMID: 23817978; PMCID: PMC3889384.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    49. Sociocommunicative and sensorimotor impairments in male P2X4-deficient mice. Neuropsychopharmacology. 2013 Sep; 38(10):1993-2002. Wyatt LR, Godar SC, Khoja S, Jakowec MW, Alkana RL, Bortolato M, Davies DL. PMID: 23604007; PMCID: PMC3746707.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    50. Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin. Int J Neuropsychopharmacol. 2013 Jun; 16(5):1059-70. Bortolato M, Yardley MM, Khoja S, Godar SC, Asatryan L, Finn DA, Alkana RL, Louie SG, Davies DL. PMID: 23174033; PMCID: PMC3593990.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    51. Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders. Alcohol Clin Exp Res. 2013 Jan; 37(1):8-15. Davies DL, Bortolato M, Finn DA, Ramaker MJ, Barak S, Ron D, Liang J, Olsen RW. PMID: 22671690; PMCID: PMC3443504.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    52. Ivermectin reduces alcohol intake and preference in mice. Neuropharmacology. 2012 Aug; 63(2):190-201. Yardley MM, Wyatt L, Khoja S, Asatryan L, Ramaker MJ, Finn DA, Alkana RL, Huynh N, Louie SG, Petasis NA, Bortolato M, Davies DL. PMID: 22465817; PMCID: PMC3372603.
      View in: PubMed   Mentions: 40     Fields:    Translation:Animals
    53. Charge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptors. J Pharmacol Exp Ther. 2012 May; 341(2):543-51. Perkins DI, Trudell JR, Asatryan L, Davies DL, Alkana RL. PMID: 22357974; PMCID: PMC3336819.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    54. Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution. Alcohol Clin Exp Res. 2011 Sep; 35(9):1561-73. Howard RJ, Slesinger PA, Davies DL, Das J, Trudell JR, Harris RA. PMID: 21676006; PMCID: PMC3201783.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    55. Implication of the purinergic system in alcohol use disorders. Alcohol Clin Exp Res. 2011 Apr; 35(4):584-94. Asatryan L, Nam HW, Lee MR, Thakkar MM, Saeed Dar M, Davies DL, Choi DS. PMID: 21223299; PMCID: PMC3076125.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    56. Ethanol is a fast channel inhibitor of P2X4 receptors. J Pharmacol Exp Ther. 2011 Apr; 337(1):171-9. Ostrovskaya O, Asatryan L, Wyatt L, Popova M, Li K, Peoples RW, Alkana RL, Davies DL. PMID: 21212160; PMCID: PMC3063738.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    57. Functional role of the intracellular loop linking transmembrane domains 6 and 7 of the human dipeptide transporter hPEPT1. J Membr Biol. 2010 Dec; 238(1-3):43-9. Xu L, Li Y, Haworth IS, Davies DL. PMID: 21104182; PMCID: PMC3032433.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    58. Ivermectin antagonizes ethanol inhibition in purinergic P2X4 receptors. J Pharmacol Exp Ther. 2010 Sep 01; 334(3):720-8. Asatryan L, Popova M, Perkins D, Trudell JR, Alkana RL, Davies DL. PMID: 20543096; PMCID: PMC2939657.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    59. Molecular targets and mechanisms for ethanol action in glycine receptors. Pharmacol Ther. 2010 Jul; 127(1):53-65. Perkins DI, Trudell JR, Crawford DK, Alkana RL, Davies DL. PMID: 20399807; PMCID: PMC2891126.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    60. A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors. J Neurochem. 2010 Jan; 112(1):307-17. Popova M, Asatryan L, Ostrovskaya O, Wyatt LR, Li K, Alkana RL, Davies DL. PMID: 19878433; PMCID: PMC2809143.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    61. Mutagenesis and cysteine scanning of transmembrane domain 10 of the human dipeptide transporter. Pharm Res. 2009 Oct; 26(10):2358-66. Xu L, Haworth IS, Kulkarni AA, Bolger MB, Davies DL. PMID: 19685173; PMCID: PMC2861424.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    62. Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity. J Biol Chem. 2009 Oct 02; 284(40):27304-14. Perkins DI, Trudell JR, Crawford DK, Asatryan L, Alkana RL, Davies DL. PMID: 19656948; PMCID: PMC2785658.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    63. Roles for loop 2 residues of alpha1 glycine receptors in agonist activation. J Biol Chem. 2008 Oct 10; 283(41):27698-27706. Crawford DK, Perkins DI, Trudell JR, Bertaccini EJ, Davies DL, Alkana RL. PMID: 18658152; PMCID: PMC2562068.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    64. Roles of ectodomain and transmembrane regions in ethanol and agonist action in purinergic P2X2 and P2X3 receptors. Neuropharmacology. 2008 Oct; 55(5):835-43. Asatryan L, Popova M, Woodward JJ, King BF, Alkana RL, Davies DL. PMID: 18639563; PMCID: PMC2629788.
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    65. Purinergic type 2 receptors at GABAergic synapses on ventral tegmental area dopamine neurons are targets for ethanol action. J Pharmacol Exp Ther. 2008 Oct; 327(1):196-205. Xiao C, Zhou C, Li K, Davies DL, Ye JH. PMID: 18583548; PMCID: PMC2861430.
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    66. Targets for ethanol action and antagonism in loop 2 of the extracellular domain of glycine receptors. J Neurochem. 2008 Aug; 106(3):1337-49. Perkins DI, Trudell JR, Crawford DK, Alkana RL, Davies DL. PMID: 18485105; PMCID: PMC4409138.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    67. Ethanol inhibits functional activity of the human intestinal dipeptide transporter hPepT1 expressed in Xenopus oocytes. Alcohol Clin Exp Res. 2008 May; 32(5):777-84. Li K, Xu L, Kulkarni AA, Perkins DI, Haworth IS, Davies DL. PMID: 18336632; PMCID: PMC2861421.
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    68. Evidence that ethanol acts on a target in Loop 2 of the extracellular domain of alpha1 glycine receptors. J Neurochem. 2007 Sep; 102(6):2097-2109. Crawford DK, Trudell JR, Bertaccini EJ, Li K, Davies DL, Alkana RL. PMID: 17561937.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    69. Cysteine scanning of transmembrane domain three of the human dipeptide transporter: implications for substrate transport. J Drug Target. 2007 Apr; 15(3):218-25. Links JL, Kulkarni AA, Davies DL, Lee VH, Haworth IS. PMID: 17454359.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    70. A charge pair interaction between Arg282 in transmembrane segment 7 and Asp341 in transmembrane segment 8 of hPepT1. Pharm Res. 2007 Jan; 24(1):66-72. Kulkarni AA, Davies DL, Links JS, Patel LN, Lee VH, Haworth IS. PMID: 17009102.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    71. Effects of ethanol on adenosine 5'-triphosphate-gated purinergic and 5-hydroxytryptamine receptors. Alcohol Clin Exp Res. 2006 Feb; 30(2):349-58. Davies DL, Asatryan L, Kuo ST, Woodward JJ, King BF, Alkana RL, Xiao C, Ye JH, Sun H, Zhang L, Hu XQ, Hayrapetyan V, Lovinger DM, Machu TK. PMID: 16441284; PMCID: PMC1448702.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    72. Differential effects of propofol and ethanol on P2X4 receptors expressed in Xenopus oocytes. Int Congr Ser. 2005 Nov; 1283:285-287. Davies DL, Kuo ST, Alkana RL. PMID: 16570112; PMCID: PMC1415272.
      View in: PubMed   Mentions: 3  
    73. Ethanol differentially affects ATP-gated P2X(3) and P2X(4) receptor subtypes expressed in Xenopus oocytes. Neuropharmacology. 2005 Aug; 49(2):243-53. Davies DL, Kochegarov AA, Kuo ST, Kulkarni AA, Woodward JJ, King BF, Alkana RL. PMID: 15993446.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    74. Effects of the abused solvent toluene on recombinant P2X receptors expressed in HEK293 cells. Brain Res Mol Brain Res. 2004 Jun 18; 125(1-2):86-95. Woodward JJ, Nowak M, Davies DL. PMID: 15193425.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    75. Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism. J Neurochem. 2004 Jun; 89(5):1175-85. Davies DL, Crawford DK, Trudell JR, Mihic SJ, Alkana RL. PMID: 15147510.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    76. Biophysical evidence for His57 as a proton-binding site in the mammalian intestinal transporter hPepT1. Pharm Res. 2003 Dec; 20(12):1911-6. Uchiyama T, Kulkarni AA, Davies DL, Lee VH. PMID: 14725353.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    77. Benzodiazepine agonist and inverse agonist coupling in GABAA receptors antagonized by increased atmospheric pressure. Eur J Pharmacol. 2003 May 23; 469(1-3):37-45. Davies DL, Alkana RL. PMID: 12782183.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    78. Ethanol potentiation of glycine receptors expressed in Xenopus oocytes antagonized by increased atmospheric pressure. Alcohol Clin Exp Res. 2003 May; 27(5):743-55. Davies DL, Trudell JR, Mihic SJ, Crawford DK, Alkana RL. PMID: 12766618.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    79. Pressure-sensitive and -insensitive coupling in gamma-aminobutyric acid(A) receptors. Psychopharmacology (Berl). 2001 Oct; 157(4):401-10. Davies DL, McCauley LD, Bolger MB, Alkana RL. PMID: 11605100.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    80. Ethanol enhances GABAA receptor function in short sleep and long sleep mouse brain membranes. Alcohol Clin Exp Res. 2001 Mar; 25(3):478-83. Davies DL, Alkana RL. PMID: 11290862.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    81. Effects of posttraining ethanol on an appetitive task. Neurobiol Learn Mem. 2001 Jan; 75(1):111-20. Ladner CJ, Babbini M, Davies DL, Parker ES, Alkana RL. PMID: 11124050.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    82. In vivo and in vitro hyperbaric studies in mice suggest novel sites of action for ethanol. Psychopharmacology (Berl). 1999 Feb; 141(4):339-50. Davies DL, Bolger MB, Brinton RD, Finn DA, Alkana RL. PMID: 10090641.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    83. Direct antagonism of ethanol's effects on GABA(A) receptors by increased atmospheric pressure. Alcohol Clin Exp Res. 1998 Nov; 22(8):1689-97. Davies DL, Alkana RL. PMID: 9835282.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    84. Proliferation of astroglia from the adult human cerebrum is inhibited by ethanol in vitro. Brain Res. 1996 Aug 26; 731(1-2):39-44. Kane CJ, Berry A, Boop FA, Davies DL. PMID: 8883852.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    85. Parenterally administered 3-nitropropionic acid and amphetamine can combine to produce damage to terminals and cell bodies in the striatum. Brain Res. 1996 Mar 18; 712(2):221-9. Bowyer JF, Clausing P, Schmued L, Davies DL, Binienda Z, Newport GD, Scallet AC, Slikker W. PMID: 8814896.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    86. Effect of 12 atmospheres helium-oxygen on the response of mice to convulsant drugs. Undersea Hyperb Med. 1996 Mar; 23(1):35-41. Syapin PJ, Jones BL, Finn DA, Davies DL, Alkana RL. PMID: 8653064.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    87. Low level hyperbaric antagonism of diazepam's locomotor depressant and anticonvulsant properties in mice. J Pharmacol Exp Ther. 1996 Feb; 276(2):667-75. Davies DL, Bejanian M, Parker ES, Mørland J, Bolger MB, Brinton RD, Alkana RL. PMID: 8632335.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    88. Low-level hyperbaric exposure antagonizes locomotor effects of ethanol and n-propanol but not morphine in C57BL mice. Alcohol Clin Exp Res. 1995 Jun; 19(3):693-700. Alkana RL, Davies DL, Mørland J, Parker ES, Bejanian M. PMID: 7573795.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    89. Low-level hyperbaric antagonism of ethanol's anticonvulsant property in C57BL/6J mice. Alcohol Clin Exp Res. 1994 Oct; 18(5):1190-5. Davies DL, Mørland J, Jones BL, Alkana RL. PMID: 7847605.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    90. Delayed growth and maturation of astrocytic cultures following exposure to ethanol: electron microscopic observations. Brain Res. 1991 Apr 26; 547(1):53-61. Davies DL, Cox WE. PMID: 1860071.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    91. Responses in astrocytic C6 glioma cells to ethanol and dibutyryl cyclic AMP. Brain Res. 1986 Jan; 389(1-2):253-60. Davies DL, Vernadakis A. PMID: 2868787.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
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