Daniel Philipp Holschneider, MD

Title(s)Professor of Psychiatry & The Behavioral Sciences
SchoolKeck School of Medicine of USC
Phone+1 323 442 1536
vCardDownload vCard
    Other Positions
    Title(s)Assistant Director of Consult/Liaison Psychiatry For LAC+USC

    Collapse Overview 
    Collapse Overview
    My laboratory's primary interest over the past 15 years has been the brain imaging of rodent behaviors as they occur in the nontethered, nonrestrained animal. A primary tool has been perfusion based mapping using the classic autoradiographic methods. Unique about our methods is that they allow us to evaluate changes in functional brain activation at the circuit level across the entire brain. Perfusion or metabolic mapping, as we have proposed, fills a gap in the current armamentarium of imaging tools in that it can deliver a 3D assessment of functional activation of the awake, nonrestrained animal, with a spatial resolution of 100 microns.
    We have made significant contributions to the methodology in several areas (a) adapting statistical parametric mapping and connectivity analyses to three-dimensional autoradiographic data sets of the rat and mouse brain, (b) developing methods to allow the generation of cortical flat maps in rats and, (c) developing an implantable minipump that allows radiotracer bolus administration by remote activation in the freely moving animal. An ongoing focus is the application of functional connectivity analyses [correlation matrices of regional changes in CBF, graph theoretical analysis of network ?hubs? (Pajek software), effective connectivity analyses using structural equation modeling].
    The lab has broad experience evaluating behavioral function in rat and mouse models of pain, brain injury, and fear, as well as exercise. Extensive experience is available for vascular surgical procedures in rats, mice and rabbits, as well as expertise in physiologic monitoring (locomotor activity, telemetric monitoring of EMG, EEG, ECG, cardiac output).

    The expertise of the laboratory include functional brain mapping, animal behavior, physiologic monitoring (EEG, EMG, EKG) and basic histochemistry.

    Collapse Research 
    Collapse Research Activities and Funding
    Positive allosteric modulation of cholinergic receptors in recovery after brain trauma
    NIH/NINDS R21NS096554Jun 1, 2016 - May 31, 2018
    Role: Principal Investigator
    Functional Adaptation of Neural Circuits After Exercise and Basal Ganglia Injury
    NIH/NICHD R01HD060630Jul 15, 2010 - May 31, 2015
    Role: Principal Investigator
    Monitoring of Cardiovascular Function in Infants By Transcutaneous Dye Dilution
    NIH/NHLBI R01HL103765Jul 1, 2010 - Jun 30, 2014
    Role: Principal Investigator
    Implantable Minipump For Tetherless Drug Self-Administration In Mice
    NIH/NIDA R21DA026970Aug 15, 2009 - Jul 31, 2011
    Role: Principal Investigator
    Microinfusion Pump For Animal Functional Brain Mapping
    NIH/NINDS R01NS050171Jul 1, 2005 - Jun 30, 2009
    Role: Principal Investigator
    PET Behavioral Brain Mapping In Freely Moving Animals
    NIH/NIMH R21MH073000Feb 1, 2005 - Jan 31, 2009
    Role: Principal Investigator
    NIH/NIBIB R01EB000300Aug 1, 2000 - Jan 31, 2005
    Role: Principal Investigator
    NIH/NIMH R01MH062148Aug 1, 2000 - Jul 31, 2003
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Holschneider DP, Guo Y, Wang Z, Vidal M, Scremin OU. Positive allosteric modulation of cholinergic receptors improves spatial learning following cortical contusion injury in mice. J Neurotrauma. 2019 Jan 28. PMID: 30688147.
      View in: PubMed
    2. Guo Y, Wang Z, Prathap S, Holschneider DP. Recruitment of prefrontal-striatal circuit in response to skilled motor challenge. Neuroreport. 2017 Dec 13; 28(18):1187-1194. PMID: 28901999.
      View in: PubMed
    3. Wang Z, Chang HH, Gao Y, Zhang R, Guo Y, Holschneider DP, Rodriguez LV. Effects of water avoidance stress on peripheral and central responses during bladder filling in the rat: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome (MAPP) research network study. PLoS One. 2017; 12(9):e0182976. PMID: 28886046.
      View in: PubMed
    4. Jakowec MW, Wang Z, Holschneider D, Beeler J, Petzinger GM. Engaging cognitive circuits to promote motor recovery in degenerative disorders. exercise as a learning modality. J Hum Kinet. 2016 Sep 01; 52:35-51. PMID: 28149392.
      View in: PubMed
    5. Maarek JM, Rubinstein EH, Guo Y, Lane CJ, Campese VM, Holschneider DP. Measurement of Cardiac Output and Blood Volume During Hemodialysis with Fluorescent Dye Dilution Technique. Ann Biomed Eng. 2017 03; 45(3):580-591. PMID: 27539225.
      View in: PubMed
    6. Wang Z, Stefanko DP, Guo Y, Toy WA, Petzinger GM, Jakowec MW, Holschneider DP. Evidence of functional brain reorganization on the basis of blood flow changes in the CAG140 knock-in mouse model of Huntington's disease. Neuroreport. 2016 06 15; 27(9):632-9. PMID: 27082842.
      View in: PubMed
    7. Wang Z, Guo Y, Myers KG, Heintz R, Holschneider DP. Recruitment of the prefrontal cortex and cerebellum in Parkinsonian rats following skilled aerobic exercise. Neurobiol Dis. 2015 May; 77:71-87. PMID: 25747184; PMCID: PMC4402279.
    8. Guo Y, Wang Z, Mayer EA, Holschneider DP. Neonatal stress from limited bedding elicits visceral hyperalgesia in adult rats. Neuroreport. 2015 Jan 07; 26(1):13-6. PMID: 25426824; PMCID: PMC4246414.
    9. Peng YH, Heintz R, Wang Z, Guo Y, Myers KG, Scremin OU, Maarek JM, Holschneider DP. Exercise training reinstates cortico-cortical sensorimotor functional connectivity following striatal lesioning: development and application of a subregional-level analytic toolbox for perfusion autoradiographs of the rat brain. Front Phys. 2014 Dec 03; 2. PMID: 25745629.
      View in: PubMed
    10. Wang Z, Guo Y, Myers KG, Heintz R, Peng YH, Maarek JM, Holschneider DP. Exercise alters resting-state functional connectivity of motor circuits in parkinsonian rats. Neurobiol Aging. 2015 Jan; 36(1):536-44. PMID: 25219465; PMCID: PMC4267985.
    11. Holschneider DP, Wang Z, Pang RD. Functional connectivity-based parcellation and connectome of cortical midline structures in the mouse: a perfusion autoradiography study. Front Neuroinform. 2014; 8:61. PMID: 24966831; PMCID: PMC4052632.
    12. Wang Z, Myers KG, Guo Y, Ocampo MA, Pang RD, Jakowec MW, Holschneider DP. Functional reorganization of motor and limbic circuits after exercise training in a rat model of bilateral parkinsonism. PLoS One. 2013; 8(11):e80058. PMID: 24278239; PMCID: PMC3836982.
    13. Holschneider DP, Guo Y, Wang Z, Roch M, Scremin OU. Remote brain network changes after unilateral cortical impact injury and their modulation by acetylcholinesterase inhibition. J Neurotrauma. 2013 Jun 01; 30(11):907-19. PMID: 23343118; PMCID: PMC3684212.
    14. Wang Z, Ocampo MA, Pang RD, Bota M, Bradesi S, Mayer EA, Holschneider DP. Alterations in prefrontal-limbic functional activation and connectivity in chronic stress-induced visceral hyperalgesia. PLoS One. 2013; 8(3):e59138. PMID: 23527114; PMCID: PMC3602545.
    15. Scremin OU, Norman KM, Roch M, Holschneider DP, Scremin AM. Acetylcholinesterase inhibition interacts with training to reverse spatial learning deficits after cortical impact injury. J Neurotrauma. 2012 Oct 10; 29(15):2457-64. PMID: 22738336.
      View in: PubMed
    16. Pang RD, Holschneider DP, Miller JD. Circadian rhythmicity in serotonin transporter knockout mice. Life Sci. 2012 Oct 05; 91(11-12):365-368. PMID: 22884802.
      View in: PubMed
    17. Abulseoud OA, Miller JD, Wu J, Choi DS, Holschneider DP. Ceftriaxone upregulates the glutamate transporter in medial prefrontal cortex and blocks reinstatement of methamphetamine seeking in a condition place preference paradigm. Brain Res. 2012 May 25; 1456:14-21. PMID: 22521042; PMCID: PMC3922613.
    18. Wang Z, Pang RD, Hernandez M, Ocampo MA, Holschneider DP. Anxiolytic-like effect of pregabalin on unconditioned fear in the rat: an autoradiographic brain perfusion mapping and functional connectivity study. Neuroimage. 2012 Feb 15; 59(4):4168-88. PMID: 22155030.
      View in: PubMed
    19. Wang Z, Bradesi S, Charles JR, Pang RD, Maarek JM, Mayer EA, Holschneider DP. Functional brain activation during retrieval of visceral pain-conditioned passive avoidance in the rat. Pain. 2011 Dec; 152(12):2746-56. PMID: 21944154; PMCID: PMC3215895.
    20. Holschneider DP, Guo Y, Roch M, Norman KM, Scremin OU. Acetylcholinesterase inhibition and locomotor function after motor-sensory cortex impact injury. J Neurotrauma. 2011 Sep; 28(9):1909-19. PMID: 21787180.
      View in: PubMed
    21. Pang RD, Wang Z, Klosinski LP, Guo Y, Herman DH, Celikel T, Dong HW, Holschneider DP. Mapping functional brain activation using [14C]-iodoantipyrine in male serotonin transporter knockout mice. PLoS One. 2011; 6(8):e23869. PMID: 21886833; PMCID: PMC3160305.
    22. Sadler TR, Nguyen PT, Yang J, Givrad TK, Mayer EA, Maarek JM, Hinton DR, Holschneider DP. Antenatal maternal stress alters functional brain responses in adult offspring during conditioned fear. Brain Res. 2011 Apr 18; 1385:163-74. PMID: 21300034; PMCID: PMC3065538.
    23. Petzinger GM, Fisher BE, Akopian G, Holschneider DP, Wood R, Walsh JP, Lund B, Meshul C, Vuckovic M, Jakowec MW. The role of exercise in facilitating basal ganglia function in Parkinson's disease. Neurodegener Dis Manag. 2011 Apr 01; 1(2):157-170. PMID: 23805167.
      View in: PubMed
    24. Holschneider DP, Bradesi S, Mayer EA. The role of experimental models in developing new treatments for irritable bowel syndrome. Expert Rev Gastroenterol Hepatol. 2011 Feb; 5(1):43-57. PMID: 21309671; PMCID: PMC3124306.
    25. Petzinger GM, Fisher BE, Van Leeuwen JE, Vukovic M, Akopian G, Meshul CK, Holschneider DP, Nacca A, Walsh JP, Jakowec MW. Enhancing neuroplasticity in the basal ganglia: the role of exercise in Parkinson's disease. Mov Disord. 2010; 25 Suppl 1:S141-5. PMID: 20187247; PMCID: PMC4111643.
    26. Givrad TK, Maarek JM, Moore WH, Holschneider DP. Powering an implantable minipump with a multi-layered printed circuit coil for drug infusion applications in rodents. Ann Biomed Eng. 2010 Mar; 38(3):707-13. PMID: 20033778; PMCID: PMC4103610.
    27. Li PY, Givrad TK, Holschneider DP, Maarek JM, Meng E. A Parylene MEMS Electrothermal Valve. J Microelectromech Syst. 2009 Dec; 18(6):1184-1197. PMID: 21350679.
      View in: PubMed
    28. Li PY, Givrad TK, Sheybani R, Holschneider DP, Maarek JM, Meng E. A low power, on demand electrothermal valve for wireless drug delivery applications. Lab Chip. 2010 Jan 07; 10(1):101-10. PMID: 20024057; PMCID: PMC4134919.
    29. Maarek JM, Holschneider DP. Estimation of indocyanine green concentration in blood from fluorescence emission: application to hemodynamic assessment during hemodialysis. J Biomed Opt. 2009 Sep-Oct; 14(5):054006. PMID: 19895108.
      View in: PubMed
    30. Wang Z, Guo Y, Bradesi S, Labus JS, Maarek JI, Lee K, Winchester WJ, Mayer EA, Holschneider DP. Sex differences in functional brain activation during noxious visceral stimulation in rats. Pain. 2009 Sep; 145(1-2):120-128. PMID: 19560270; PMCID: PMC2756542.
    31. Sadler TR, Khodavirdi AC, Hinton DR, Holschneider DP. Snap-frozen brain tissue sections stored with desiccant at ambient laboratory conditions without chemical fixation are resistant to degradation for a minimum of 6 months. Appl Immunohistochem Mol Morphol. 2009 Mar; 17(2):165-71. PMID: 19521279; PMCID: PMC2742633.
    32. Tillisch K, Wang Z, Kilpatrick L, Holschneider DP, Mayer EA. Studying the brain-gut axis with pharmacological imaging. Ann N Y Acad Sci. 2008 Nov; 1144:256-64. PMID: 19076383; PMCID: PMC3817712.
    33. Vuckovic MG, Wood RI, Holschneider DP, Abernathy A, Togasaki DM, Smith A, Petzinger GM, Jakowec MW. Memory, mood, dopamine, and serotonin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury. Neurobiol Dis. 2008 Nov; 32(2):319-27. PMID: 18718537; PMCID: PMC3280725.
    34. Holschneider DP, Yang J, Sadler TR, Galifianakis NB, Bozorgzadeh MH, Bading JR, Conti PS, Maarek JM. Changes in regional brain perfusion during functional brain activation: comparison of [(64)Cu]-PTSM with [(14)C]-Iodoantipyrine. Brain Res. 2008 Oct 09; 1234:32-43. PMID: 18687316; PMCID: PMC2578839.
    35. Holschneider DP, Maarek JM. Brain maps on the go: functional imaging during motor challenge in animals. Methods. 2008 Aug; 45(4):255-61. PMID: 18554522; PMCID: PMC2561174.
    36. Wang Z, Bradesi S, Maarek JM, Lee K, Winchester WJ, Mayer EA, Holschneider DP. Regional brain activation in conscious, nonrestrained rats in response to noxious visceral stimulation. Pain. 2008 Aug 15; 138(1):233-43. PMID: 18538929; PMCID: PMC3816530.
    37. Holschneider DP, Scremin OU, Chialvo DR, Kay BP, Maarek JM. Flattened cortical maps of cerebral function in the rat: a region-of-interest approach to data sampling, analysis and display. Neurosci Lett. 2008 Mar 28; 434(2):179-84. PMID: 18325664; PMCID: PMC2396341.
    38. Holschneider DP, Yang J, Guo Y, Maarek JM. Reorganization of functional brain maps after exercise training: Importance of cerebellar-thalamic-cortical pathway. Brain Res. 2007 Dec 12; 1184:96-107. PMID: 17964551; PMCID: PMC2692362.
    39. Maarek JM, Holschneider DP, Rubinstein EH. Fluorescence dilution technique for measurement of cardiac output and circulating blood volume in healthy human subjects. Anesthesiology. 2007 Mar; 106(3):491-8. PMID: 17325507.
      View in: PubMed
    40. Moore WH, Holschneider DP, Givrad TK, Maarek JM. Transcutaneous RF-powered implantable minipump driven by a class-E transmitter. IEEE Trans Biomed Eng. 2006 Aug; 53(8):1705-8. PMID: 16916107; PMCID: PMC2074887.
    41. Holschneider DP, Yang J, Sadler TR, Nguyen PT, Givrad TK, Maarek JM. Mapping cerebral blood flow changes during auditory-cued conditioned fear in the nontethered, nonrestrained rat. Neuroimage. 2006 Feb 15; 29(4):1344-58. PMID: 16216535; PMCID: PMC1892584.
    42. Yang J, Maarek JM, Holschneider DP. In vivo quantitative assessment of catheter patency in rats. Lab Anim. 2005 Jul; 39(3):259-68. PMID: 16004684; PMCID: PMC4100546.
    43. Maarek JM, Holschneider DP, Yang J, Pniak SN, Rubinstein EH. Transcutaneous fluorescence dilution cardiac output and circulating blood volume during hemorrhagic hypovolemia. Anesthesiology. 2005 Apr; 102(4):774-82. PMID: 15791107.
      View in: PubMed
    44. Holschneider DP, Maarek JM. Mapping brain function in freely moving subjects. Neurosci Biobehav Rev. 2004 Sep; 28(5):449-61. PMID: 15465134; PMCID: PMC4103625.
    45. Nguyen PT, Holschneider DP, Maarek JM, Yang J, Mandelkern MA. Statistical parametric mapping applied to an autoradiographic study of cerebral activation during treadmill walking in rats. Neuroimage. 2004 Sep; 23(1):252-9. PMID: 15325372; PMCID: PMC4103584.
    46. Chen K, Holschneider DP, Wu W, Rebrin I, Shih JC. A spontaneous point mutation produces monoamine oxidase A/B knock-out mice with greatly elevated monoamines and anxiety-like behavior. J Biol Chem. 2004 Sep 17; 279(38):39645-52. PMID: 15272015; PMCID: PMC2861902.
    47. Maarek JM, Holschneider DP, Harimoto J, Yang J, Scremin OU, Rubinstein EH. Measurement of cardiac output with indocyanine green transcutaneous fluorescence dilution technique. Anesthesiology. 2004 Jun; 100(6):1476-83. PMID: 15166567.
      View in: PubMed
    48. Maragos WF, Young KL, Altman CS, Pocernich CB, Drake J, Butterfield DA, Seif I, Holschneider DP, Chen K, Shih JC. Striatal damage and oxidative stress induced by the mitochondrial toxin malonate are reduced in clorgyline-treated rats and MAO-A deficient mice. Neurochem Res. 2004 Apr; 29(4):741-6. PMID: 15098936.
      View in: PubMed
    49. Holschneider DP, Maarek JM, Yang J, Harimoto J, Scremin OU. Activation of cerebral cortex during acoustic challenge or acute foot-shock in freely moving, nontethered rats. Neurosci Lett. 2004 Jan 02; 354(1):74-8. PMID: 14698485; PMCID: PMC4111640.
    50. Holschneider DP, Maarek JM, Yang J, Harimoto J, Scremin OU. Functional brain mapping in freely moving rats during treadmill walking. J Cereb Blood Flow Metab. 2003 Aug; 23(8):925-32. PMID: 12902836; PMCID: PMC4066728.
    51. Holschneider DP, Maarek JM, Harimoto J, Yang J, Scremin OU. An implantable bolus infusion pump for use in freely moving, nontethered rats. Am J Physiol Heart Circ Physiol. 2002 Oct; 283(4):H1713-9. PMID: 12234827; PMCID: PMC4103617.