Daniel Philipp Holschneider, MD

Title(s)Professor of Psychiatry & the Behavioral Sciences
SchoolKeck School of Medicine of Usc
AddressMCA B1 1333 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 1536
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    Other Positions
    Title(s)Assistant Director of Consult/Liaison Psychiatry for LAC+USC

    Collapse Overview 
    Collapse Overview
    My laboratory's primary interest over the past 15 years has been the brain imaging of rodent behaviors as they occur in the nontethered, nonrestrained animal. A primary tool has been perfusion based mapping using the classic autoradiographic methods. Unique about our methods is that they allow us to evaluate changes in functional brain activation at the circuit level across the entire brain. Perfusion or metabolic mapping, as we have proposed, fills a gap in the current armamentarium of imaging tools in that it can deliver a 3D assessment of functional activation of the awake, nonrestrained animal, with a spatial resolution of 100 microns.
    We have made significant contributions to the methodology in several areas (a) adapting statistical parametric mapping and connectivity analyses to three-dimensional autoradiographic data sets of the rat and mouse brain, (b) developing methods to allow the generation of cortical flat maps in rats and, (c) developing an implantable minipump that allows radiotracer bolus administration by remote activation in the freely moving animal. An ongoing focus is the application of functional connectivity analyses [correlation matrices of regional changes in CBF, graph theoretical analysis of network �hubs� (Pajek software), effective connectivity analyses using structural equation modeling].
    The lab has broad experience evaluating behavioral function in rat and mouse models of pain, brain injury, and fear, as well as exercise. Extensive experience is available for vascular surgical procedures in rats, mice and rabbits, as well as expertise in physiologic monitoring (locomotor activity, telemetric monitoring of EMG, EEG, ECG, cardiac output).

    The expertise of the laboratory include functional brain mapping, animal behavior, physiologic monitoring (EEG, EMG, EKG) and basic histochemistry.

    Collapse Research 
    Collapse Research Activities and Funding
    Positive allosteric modulation of cholinergic receptors in recovery after brain trauma
    NIH R21NS096554Jun 1, 2016 - May 31, 2018
    Role: Principal Investigator
    Functional Adaptation of Neural Circuits After Exercise and Basal Ganglia Injury
    NIH R01HD060630Jul 15, 2010 - May 31, 2016
    Role: Principal Investigator
    Monitoring of Cardiovascular Function in Infants By Transcutaneous Dye Dilution
    NIH R01HL103765Jul 1, 2010 - Jun 30, 2016
    Role: Principal Investigator
    Implantable Minipump For Tetherless Drug Self-Administration In Mice
    NIH R21DA026970Aug 15, 2009 - Jul 31, 2011
    Role: Principal Investigator
    Microinfusion Pump For Animal Functional Brain Mapping
    NIH R01NS050171Jul 1, 2005 - Jun 30, 2009
    Role: Principal Investigator
    PET Behavioral Brain Mapping In Freely Moving Animals
    NIH R21MH073000Feb 1, 2005 - Jan 31, 2009
    Role: Principal Investigator
    NIH R01EB000300Aug 1, 2000 - Jan 31, 2005
    Role: Principal Investigator
    NIH R01MH062148Aug 1, 2000 - Jul 31, 2003
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Increased perivascular space volume in white matter and basal ganglia is associated with cognition in Parkinson's Disease. Brain Imaging Behav. 2024 Feb; 18(1):57-65. Donahue EK, Foreman RP, Duran JJ, Jakowec MW, O'Neill J, Petkus AJ, Holschneider DP, Choupan J, Van Horn JD, Venkadesh S, Bayram E, Litvan I, Schiehser DM, Petzinger GM. PMID: 37855955; PMCID: PMC10844402.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    2. Exercise alters cortico-basal ganglia network metabolic connectivity: a mesoscopic level analysis informed by anatomic parcellation defined in the mouse brain connectome. Brain Struct Funct. 2023 Nov; 228(8):1865-1884. Wang Z, Donahue EK, Guo Y, Renteln M, Petzinger GM, Jakowec MW, Holschneider DP. PMID: 37306809; PMCID: PMC10516800.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. Physical activity intensity is associated with cognition and functional connectivity in Parkinson's disease. Parkinsonism Relat Disord. 2022 Nov; 104:7-14. Donahue EK, Venkadesh S, Bui V, Tuazon AC, Wang RK, Haase D, Foreman RP, Duran JJ, Petkus A, Wing D, Higgins M, Holschneider DP, Bayram E, Litvan I, Jakowec MW, Van Horn JD, Schiehser DM, Petzinger GM. PMID: 36191358.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    4. A mind in motion: Exercise improves cognitive flexibility, impulsivity and alters dopamine receptor gene expression in a Parkinsonian rat model. Curr Res Neurobiol. 2022; 3:100039. Zhuo W, Lundquist AJ, Donahue EK, Guo Y, Phillips D, Petzinger GM, Jakowec MW, Holschneider DP. PMID: 36518341; PMCID: PMC9743054.
      View in: PubMed   Mentions: 2  
    5. A gut-derived metabolite alters brain activity and anxiety behaviour in mice. Nature. 2022 02; 602(7898):647-653. Needham BD, Funabashi M, Adame MD, Wang Z, Boktor JC, Haney J, Wu WL, Rabut C, Ladinsky MS, Hwang SJ, Guo Y, Zhu Q, Griffiths JA, Knight R, Bjorkman PJ, Shapiro MG, Geschwind DH, Holschneider DP, Fischbach MA, Mazmanian SK. PMID: 35165440; PMCID: PMC9170029.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    6. The Effects of Cardiorespiratory and Motor Skill Fitness on Intrinsic Functional Connectivity of Neural Networks in Individuals with Parkinson's Disease. Brain Plast. 2021; 7(2):77-95. Jarrahi B, McEwen SC, Holschneider DP, Schiehser DM, Petkus AJ, Gomez ME, Van Horn JD, Filoteo V, Jakowec MW, Petzinger GM. PMID: 34868875; PMCID: PMC8609487.
      View in: PubMed   Mentions: 1  
    7. Thalamic volume mediates associations between cardiorespiratory fitness (VO2max) and cognition in Parkinson's disease. Parkinsonism Relat Disord. 2021 05; 86:19-26. Petkus AJ, Jarrahi B, Holschneider DP, Gomez ME, Filoteo JV, Schiehser DM, Fisher BE, Van Horn JD, Jakowec MW, McEwen SC, Petzinger G. PMID: 33819900; PMCID: PMC8375572.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    8. Cognitive flexibility deficits in rats with dorsomedial striatal 6-hydroxydopamine lesions tested using a three-choice serial reaction time task with reversal learning. Neuroreport. 2020 10 14; 31(15):1055-1064. Wang Z, Flores I, Donahue EK, Lundquist AJ, Guo Y, Petzinger GM, Jakowec MW, Holschneider DP. PMID: 32881776.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    9. Modulation of Hippocampal GABAergic Neurotransmission and Gephyrin Levels by Dihydromyricetin Improves Anxiety. Front Pharmacol. 2020; 11:1008. Silva J, Shao AS, Shen Y, Davies DL, Olsen RW, Holschneider DP, Shao XM, Liang J. PMID: 32742262; PMCID: PMC7364153.
      View in: PubMed   Mentions: 6  
    10. Ceftriaxone inhibits stress-induced bladder hyperalgesia and alters cerebral micturition and nociceptive circuits in the rat: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome research network study. Neurourol Urodyn. 2020 08; 39(6):1628-1643. Holschneider DP, Wang Z, Chang H, Zhang R, Gao Y, Guo Y, Mao J, Rodriguez LV. PMID: 32578247; PMCID: PMC7642011.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    11. Voluntary exercise improves voiding function and bladder hyperalgesia in an animal model of stress-induced visceral hypersensitivity: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome research network study. Neurourol Urodyn. 2020 02; 39(2):603-612. Sanford MT, Yeh JC, Mao JJ, Guo Y, Wang Z, Zhang R, Holschneider DP, Rodriguez LV. PMID: 31944369; PMCID: PMC7043234.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    12. Exercise modulates neuronal activation in the micturition circuit of chronically stressed rats: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome (MAPP) research network study. Physiol Behav. 2020 03 01; 215:112796. Holschneider DP, Wang Z, Guo Y, Sanford MT, Yeh J, Mao JJ, Zhang R, Rodriguez LV. PMID: 31884113; PMCID: PMC7269603.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    13. Hypothalamus-hippocampus circuitry regulates impulsivity via melanin-concentrating hormone. Nat Commun. 2019 10 29; 10(1):4923. Noble EE, Wang Z, Liu CM, Davis EA, Suarez AN, Stein LM, Tsan L, Terrill SJ, Hsu TM, Jung AH, Raycraft LM, Hahn JD, Darvas M, Cortella AM, Schier LA, Johnson AW, Hayes MR, Holschneider DP, Kanoski SE. PMID: 31664021; PMCID: PMC6820566.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    14. Cerebral perfusion mapping during retrieval of spatial memory in rats. Behav Brain Res. 2019 12 16; 375:112116. Holschneider DP, Givrad TK, Yang J, Stewart SB, Francis SR, Wang Z, Maarek J. PMID: 31377254; PMCID: PMC6748870.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    15. Sex differences in insular functional connectivity in response to noxious visceral stimulation in rats. Brain Res. 2019 08 15; 1717:15-26. Wang Z, Guo Y, Mayer EA, Holschneider DP. PMID: 30974090; PMCID: PMC6711370.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    16. Positive Allosteric Modulation of Cholinergic Receptors Improves Spatial Learning after Cortical Contusion Injury in Mice. J Neurotrauma. 2019 07 15; 36(14):2233-2245. Holschneider DP, Guo Y, Wang Z, Vidal M, Scremin OU. PMID: 30688147; PMCID: PMC6653801.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    17. Recruitment of prefrontal-striatal circuit in response to skilled motor challenge. Neuroreport. 2017 Dec 13; 28(18):1187-1194. Guo Y, Wang Z, Prathap S, Holschneider DP. PMID: 28901999; PMCID: PMC5685897.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    18. Effects of water avoidance stress on peripheral and central responses during bladder filling in the rat: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome (MAPP) research network study. PLoS One. 2017; 12(9):e0182976. Wang Z, Chang HH, Gao Y, Zhang R, Guo Y, Holschneider DP, Rodriguez LV. PMID: 28886046; PMCID: PMC5590813.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    19. Engaging cognitive circuits to promote motor recovery in degenerative disorders. exercise as a learning modality. J Hum Kinet. 2016 Sep 01; 52:35-51. Jakowec MW, Wang Z, Holschneider D, Beeler J, Petzinger GM. PMID: 28149392; PMCID: PMC5260516.
      View in: PubMed   Mentions: 4  
    20. Measurement of Cardiac Output and Blood Volume During Hemodialysis with Fluorescent Dye Dilution Technique. Ann Biomed Eng. 2017 03; 45(3):580-591. Maarek JM, Rubinstein EH, Guo Y, Lane CJ, Campese VM, Holschneider DP. PMID: 27539225; PMCID: PMC8380453.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    21. Evidence of functional brain reorganization on the basis of blood flow changes in the CAG140 knock-in mouse model of Huntington's disease. Neuroreport. 2016 06 15; 27(9):632-9. Wang Z, Stefanko DP, Guo Y, Toy WA, Petzinger GM, Jakowec MW, Holschneider DP. PMID: 27082842.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    22. Early life stress elicits visceral hyperalgesia and functional reorganization of pain circuits in adult rats. Neurobiol Stress. 2016 Jun 01; 3:8-22. Holschneider DP, Guo Y, Mayer EA, Wang Z. PMID: 26751119; PMCID: PMC4700548.
      View in: PubMed   Mentions: 12  
    23. Recruitment of the prefrontal cortex and cerebellum in Parkinsonian rats following skilled aerobic exercise. Neurobiol Dis. 2015 May; 77:71-87. Wang Z, Guo Y, Myers KG, Heintz R, Holschneider DP. PMID: 25747184; PMCID: PMC4402279.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    24. Prone positioning decreases cardiac output and increases systemic vascular resistance in neonates. J Perinatol. 2015 Jun; 35(6):424-7. Ma M, Noori S, Maarek JM, Holschneider DP, Rubinstein EH, Seri I. PMID: 25590219.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    25. Neonatal stress from limited bedding elicits visceral hyperalgesia in adult rats. Neuroreport. 2015 Jan 07; 26(1):13-6. Guo Y, Wang Z, Mayer EA, Holschneider DP. PMID: 25426824; PMCID: PMC4246414.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    26. The Effects of Exercise on Dopamine Neurotransmission in Parkinson's Disease: Targeting Neuroplasticity to Modulate Basal Ganglia Circuitry. Brain Plast. 2015; 1(1):29-39. Petzinger GM, Holschneider DP, Fisher BE, McEwen S, Kintz N, Halliday M, Toy W, Walsh JW, Beeler J, Jakowec MW. PMID: 26512345; PMCID: PMC4621077.
      View in: PubMed   Mentions: 46  
    27. Exercise training reinstates cortico-cortical sensorimotor functional connectivity following striatal lesioning: development and application of a subregional-level analytic toolbox for perfusion autoradiographs of the rat brain. Front Phys. 2014 Dec 03; 2. Peng YH, Heintz R, Wang Z, Guo Y, Myers KG, Scremin OU, Maarek JM, Holschneider DP. PMID: 25745629; PMCID: PMC4347897.
      View in: PubMed   Mentions: 3  
    28. Exercise alters resting-state functional connectivity of motor circuits in parkinsonian rats. Neurobiol Aging. 2015 Jan; 36(1):536-44. Wang Z, Guo Y, Myers KG, Heintz R, Peng YH, Maarek JM, Holschneider DP. PMID: 25219465; PMCID: PMC4267985.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    29. Functional connectivity-based parcellation and connectome of cortical midline structures in the mouse: a perfusion autoradiography study. Front Neuroinform. 2014; 8:61. Holschneider DP, Wang Z, Pang RD. PMID: 24966831; PMCID: PMC4052632.
      View in: PubMed   Mentions: 7  
    30. Functional reorganization of motor and limbic circuits after exercise training in a rat model of bilateral parkinsonism. PLoS One. 2013; 8(11):e80058. Wang Z, Myers KG, Guo Y, Ocampo MA, Pang RD, Jakowec MW, Holschneider DP. PMID: 24278239; PMCID: PMC3836982.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    31. Remote brain network changes after unilateral cortical impact injury and their modulation by acetylcholinesterase inhibition. J Neurotrauma. 2013 Jun 01; 30(11):907-19. Holschneider DP, Guo Y, Wang Z, Roch M, Scremin OU. PMID: 23343118; PMCID: PMC3684212.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    32. Alterations in prefrontal-limbic functional activation and connectivity in chronic stress-induced visceral hyperalgesia. PLoS One. 2013; 8(3):e59138. Wang Z, Ocampo MA, Pang RD, Bota M, Bradesi S, Mayer EA, Holschneider DP. PMID: 23527114; PMCID: PMC3602545.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    33. Acetylcholinesterase inhibition interacts with training to reverse spatial learning deficits after cortical impact injury. J Neurotrauma. 2012 Oct 10; 29(15):2457-64. Scremin OU, Norman KM, Roch M, Holschneider DP, Scremin AM. PMID: 22738336.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    34. Circadian rhythmicity in serotonin transporter knockout mice. Life Sci. 2012 Oct 05; 91(11-12):365-368. Pang RD, Holschneider DP, Miller JD. PMID: 22884802.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    35. Ceftriaxone upregulates the glutamate transporter in medial prefrontal cortex and blocks reinstatement of methamphetamine seeking in a condition place preference paradigm. Brain Res. 2012 May 25; 1456:14-21. Abulseoud OA, Miller JD, Wu J, Choi DS, Holschneider DP. PMID: 22521042; PMCID: PMC3922613.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    36. Anxiolytic-like effect of pregabalin on unconditioned fear in the rat: an autoradiographic brain perfusion mapping and functional connectivity study. Neuroimage. 2012 Feb 15; 59(4):4168-88. Wang Z, Pang RD, Hernandez M, Ocampo MA, Holschneider DP. PMID: 22155030.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    37. Functional brain activation during retrieval of visceral pain-conditioned passive avoidance in the rat. Pain. 2011 Dec; 152(12):2746-2756. Wang Z, Bradesi S, Charles JR, Pang RD, Maarek JI, Mayer EA, Holschneider DP. PMID: 21944154; PMCID: PMC3215895.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    38. Acetylcholinesterase inhibition and locomotor function after motor-sensory cortex impact injury. J Neurotrauma. 2011 Sep; 28(9):1909-19. Holschneider DP, Guo Y, Roch M, Norman KM, Scremin OU. PMID: 21787180.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    39. Mapping functional brain activation using [14C]-iodoantipyrine in male serotonin transporter knockout mice. PLoS One. 2011; 6(8):e23869. Pang RD, Wang Z, Klosinski LP, Guo Y, Herman DH, Celikel T, Dong HW, Holschneider DP. PMID: 21886833; PMCID: PMC3160305.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    40. Antenatal maternal stress alters functional brain responses in adult offspring during conditioned fear. Brain Res. 2011 Apr 18; 1385:163-74. Sadler TR, Nguyen PT, Yang J, Givrad TK, Mayer EA, Maarek JM, Hinton DR, Holschneider DP. PMID: 21300034; PMCID: PMC3065538.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    41. The role of exercise in facilitating basal ganglia function in Parkinson's disease. Neurodegener Dis Manag. 2011 Apr 01; 1(2):157-170. Petzinger GM, Fisher BE, Akopian G, Holschneider DP, Wood R, Walsh JP, Lund B, Meshul C, Vuckovic M, Jakowec MW. PMID: 23805167; PMCID: PMC3691073.
      View in: PubMed   Mentions: 5     Fields:    
    42. The role of experimental models in developing new treatments for irritable bowel syndrome. Expert Rev Gastroenterol Hepatol. 2011 Feb; 5(1):43-57. Holschneider DP, Bradesi S, Mayer EA. PMID: 21309671; PMCID: PMC3124306.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    43. Enhancing neuroplasticity in the basal ganglia: the role of exercise in Parkinson's disease. Mov Disord. 2010; 25 Suppl 1:S141-5. Petzinger GM, Fisher BE, Van Leeuwen JE, Vukovic M, Akopian G, Meshul CK, Holschneider DP, Nacca A, Walsh JP, Jakowec MW. PMID: 20187247; PMCID: PMC4111643.
      View in: PubMed   Mentions: 73     Fields:    Translation:Humans
    44. Powering an implantable minipump with a multi-layered printed circuit coil for drug infusion applications in rodents. Ann Biomed Eng. 2010 Mar; 38(3):707-13. Givrad TK, Maarek JM, Moore WH, Holschneider DP. PMID: 20033778; PMCID: PMC4103610.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    45. A Parylene MEMS Electrothermal Valve. J Microelectromech Syst. 2009 Dec; 18(6):1184-1197. Li PY, Givrad TK, Holschneider DP, Maarek JM, Meng E. PMID: 21350679; PMCID: PMC3042720.
      View in: PubMed   Mentions: 5  
    46. A low power, on demand electrothermal valve for wireless drug delivery applications. Lab Chip. 2010 Jan 07; 10(1):101-10. Li PY, Givrad TK, Sheybani R, Holschneider DP, Maarek JM, Meng E. PMID: 20024057; PMCID: PMC4134919.
      View in: PubMed   Mentions: 2     Fields:    
    47. Estimation of indocyanine green concentration in blood from fluorescence emission: application to hemodynamic assessment during hemodialysis. J Biomed Opt. 2009 Sep-Oct; 14(5):054006. Maarek JM, Holschneider DP. PMID: 19895108.
      View in: PubMed   Mentions: 2     Fields:    
    48. Sex differences in functional brain activation during noxious visceral stimulation in rats. Pain. 2009 Sep; 145(1-2):120-128. Wang Z, Guo Y, Bradesi S, Labus JS, Maarek JI, Lee K, Winchester WJ, Mayer EA, Holschneider DP. PMID: 19560270; PMCID: PMC2756542.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    49. Snap-frozen brain tissue sections stored with desiccant at ambient laboratory conditions without chemical fixation are resistant to degradation for a minimum of 6 months. Appl Immunohistochem Mol Morphol. 2009 Mar; 17(2):165-71. Sadler TR, Khodavirdi AC, Hinton DR, Holschneider DP. PMID: 19521279; PMCID: PMC2742633.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    50. Studying the brain-gut axis with pharmacological imaging. Ann N Y Acad Sci. 2008 Nov; 1144:256-64. Tillisch K, Wang Z, Kilpatrick L, Holschneider DP, Mayer EA. PMID: 19076383; PMCID: PMC3817712.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    51. Memory, mood, dopamine, and serotonin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury. Neurobiol Dis. 2008 Nov; 32(2):319-27. Vuckovic MG, Wood RI, Holschneider DP, Abernathy A, Togasaki DM, Smith A, Petzinger GM, Jakowec MW. PMID: 18718537; PMCID: PMC3280725.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    52. Changes in regional brain perfusion during functional brain activation: comparison of [(64)Cu]-PTSM with [(14)C]-Iodoantipyrine. Brain Res. 2008 Oct 09; 1234:32-43. Holschneider DP, Yang J, Sadler TR, Galifianakis NB, Bozorgzadeh MH, Bading JR, Conti PS, Maarek JM. PMID: 18687316; PMCID: PMC2578839.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    53. Brain maps on the go: functional imaging during motor challenge in animals. Methods. 2008 Aug; 45(4):255-61. Holschneider DP, Maarek JM. PMID: 18554522; PMCID: PMC2561174.
      View in: PubMed   Mentions: 13     Fields:    
    54. Regional brain activation in conscious, nonrestrained rats in response to noxious visceral stimulation. Pain. 2008 Aug 15; 138(1):233-243. Wang Z, Bradesi S, Maarek JI, Lee K, Winchester WJ, Mayer EA, Holschneider DP. PMID: 18538929; PMCID: PMC3816530.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    55. Flattened cortical maps of cerebral function in the rat: a region-of-interest approach to data sampling, analysis and display. Neurosci Lett. 2008 Mar 28; 434(2):179-84. Holschneider DP, Scremin OU, Chialvo DR, Kay BP, Maarek JM. PMID: 18325664; PMCID: PMC2396341.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    56. Reorganization of functional brain maps after exercise training: Importance of cerebellar-thalamic-cortical pathway. Brain Res. 2007 Dec 12; 1184:96-107. Holschneider DP, Yang J, Guo Y, Maarek JM. PMID: 17964551; PMCID: PMC2692362.
      View in: PubMed   Mentions: 40     Fields:    Translation:Animals
    57. Changes in brain functional activation during resting and locomotor states after unilateral nigrostriatal damage in rats. Neuroimage. 2007 Jul 01; 36(3):755-73. Yang J, Sadler TR, Givrad TK, Maarek JM, Holschneider DP. PMID: 17481921; PMCID: PMC2039721.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    58. Fluorescence dilution technique for measurement of cardiac output and circulating blood volume in healthy human subjects. Anesthesiology. 2007 Mar; 106(3):491-8. Maarek JM, Holschneider DP, Rubinstein EH. PMID: 17325507.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    59. Transcutaneous RF-powered implantable minipump driven by a class-E transmitter. IEEE Trans Biomed Eng. 2006 Aug; 53(8):1705-8. Moore WH, Holschneider DP, Givrad TK, Maarek JM. PMID: 16916107; PMCID: PMC2074887.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    60. Mapping cerebral blood flow changes during auditory-cued conditioned fear in the nontethered, nonrestrained rat. Neuroimage. 2006 Feb 15; 29(4):1344-58. Holschneider DP, Yang J, Sadler TR, Nguyen PT, Givrad TK, Maarek JM. PMID: 16216535; PMCID: PMC1892584.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    61. In vivo quantitative assessment of catheter patency in rats. Lab Anim. 2005 Jul; 39(3):259-68. Yang J, Maarek JM, Holschneider DP. PMID: 16004684; PMCID: PMC4100546.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    62. Transcutaneous fluorescence dilution cardiac output and circulating blood volume during hemorrhagic hypovolemia. Anesthesiology. 2005 Apr; 102(4):774-82. Maarek JM, Holschneider DP, Yang J, Pniak SN, Rubinstein EH. PMID: 15791107.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    63. Statistical parametric mapping applied to an autoradiographic study of cerebral activation during treadmill walking in rats. Neuroimage. 2004 Sep; 23(1):252-9. Nguyen PT, Holschneider DP, Maarek JM, Yang J, Mandelkern MA. PMID: 15325372; PMCID: PMC4103584.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    64. Mapping brain function in freely moving subjects. Neurosci Biobehav Rev. 2004 Sep; 28(5):449-61. Holschneider DP, Maarek JM. PMID: 15465134; PMCID: PMC4103625.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    65. A spontaneous point mutation produces monoamine oxidase A/B knock-out mice with greatly elevated monoamines and anxiety-like behavior. J Biol Chem. 2004 Sep 17; 279(38):39645-52. Chen K, Holschneider DP, Wu W, Rebrin I, Shih JC. PMID: 15272015; PMCID: PMC2861902.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    66. Measurement of cardiac output with indocyanine green transcutaneous fluorescence dilution technique. Anesthesiology. 2004 Jun; 100(6):1476-83. Maarek JM, Holschneider DP, Harimoto J, Yang J, Scremin OU, Rubinstein EH. PMID: 15166567.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    67. Striatal damage and oxidative stress induced by the mitochondrial toxin malonate are reduced in clorgyline-treated rats and MAO-A deficient mice. Neurochem Res. 2004 Apr; 29(4):741-6. Maragos WF, Young KL, Altman CS, Pocernich CB, Drake J, Butterfield DA, Seif I, Holschneider DP, Chen K, Shih JC. PMID: 15098936.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    68. Activation of cerebral cortex during acoustic challenge or acute foot-shock in freely moving, nontethered rats. Neurosci Lett. 2004 Jan 02; 354(1):74-8. Holschneider DP, Maarek JM, Yang J, Harimoto J, Scremin OU. PMID: 14698485; PMCID: PMC4111640.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    69. Functional brain mapping in freely moving rats during treadmill walking. J Cereb Blood Flow Metab. 2003 Aug; 23(8):925-32. Holschneider DP, Maarek JM, Yang J, Harimoto J, Scremin OU. PMID: 12902836; PMCID: PMC4066728.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    70. An implantable bolus infusion pump for use in freely moving, nontethered rats. Am J Physiol Heart Circ Physiol. 2002 Oct; 283(4):H1713-9. Holschneider DP, Maarek JM, Harimoto J, Yang J, Scremin OU. PMID: 12234827; PMCID: PMC4103617.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    71. Fluorescence of indocyanine green in blood: intensity dependence on concentration and stabilization with sodium polyaspartate. J Photochem Photobiol B. 2001 Dec 31; 65(2-3):157-64. Maarek JM, Holschneider DP, Harimoto J. PMID: 11809374.
      View in: PubMed   Mentions: 15     Fields:    
    72. Biochemical, behavioral, physiologic, and neurodevelopmental changes in mice deficient in monoamine oxidase A or B. Brain Res Bull. 2001 Nov 15; 56(5):453-62. Holschneider DP, Chen K, Seif I, Shih JC. PMID: 11750790; PMCID: PMC4109811.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    73. Genotype to phenotype: challenges and opportunities. Int J Dev Neurosci. 2000 Oct; 18(6):615-8. Holschneider DP, Shih JC. PMID: 10884606; PMCID: PMC4108069.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    74. Attenuation of brain high frequency electrocortical response after thiopental in early stages of Alzheimer's dementia. Psychopharmacology (Berl). 2000 Mar; 149(1):6-11. Holschneider DP, Leuchter AF. PMID: 10789876.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    75. Regional cerebral cortical activation in monoamine oxidase A-deficient mice: differential effects of chronic versus acute elevations in serotonin and norepinephrine. Neuroscience. 2000; 101(4):869-77. Holschneider DP, Scremin OU, Huynh L, Chen K, Seif I, Shih JC. PMID: 11113335; PMCID: PMC4108068.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    76. Changes in electrocortical power and coherence in response to the selective cholinergic immunotoxin 192 IgG-saporin. Exp Brain Res. 1999 May; 126(2):270-80. Holschneider DP, Waite JJ, Leuchter AF, Walton NY, Scremin OU. PMID: 10369149; PMCID: PMC4134916.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    77. Cerebral cortical blood flow maps are reorganized in MAOB-deficient mice. Brain Res. 1999 Apr 03; 824(1):36-44. Scremin OU, Holschneider DP, Chen K, Li MG, Shih JC. PMID: 10095040; PMCID: PMC4075434.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    78. Selective immunotoxin-induced cholinergic deafferentation alters blood flow distribution in the cerebral cortex. Brain Res. 1999 Feb 06; 818(1):1-11. Waite JJ, Holschneider DP, Scremin OU. PMID: 9914432.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    79. Lack of protection from ischemic injury of monoamine oxidase B-deficient mice following middle cerebral artery occlusion. Neurosci Lett. 1999 Jan 15; 259(3):161-4. Holschneider DP, Scremin OU, Huynh L, Chen K, Shih JC. PMID: 10025583.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    80. Clinical neurophysiology using electroencephalography in geriatric psychiatry: neurobiologic implications and clinical utility. J Geriatr Psychiatry Neurol. 1999; 12(3):150-64. Holschneider DP, Leuchter AF. PMID: 10593703.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    81. Lack of protection of monoamine oxidase B-deficient mice from age-related spatial learning deficits in the Morris water maze. Life Sci. 1999; 65(17):1757-63. Holschneider DP, Scremin OU, Chen K, Shih JC. PMID: 10576555.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    82. Effects of ovariectomy on cerebral flow of rats. Neuroendocrinology. 1998 Apr; 67(4):260-8. Holschneider DP, Scremin OU. PMID: 9588695.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    83. Effects of cholinergic deafferentation and NGF on brain electrical coherence. Brain Res Bull. 1998 Mar 15; 45(5):531-41. Holschneider DP, Leuchter AF, Scremin OU, Treiman DM, Walton NY. PMID: 9570724.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    84. Tissue-specific effects of estrogen on monoamine oxidase A and B in the rat. Life Sci. 1998; 63(3):155-60. Holschneider DP, Kumazawa T, Chen K, Shih JC. PMID: 9698044.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    85. Quantitative EEG effects of nicotine replacement by cigarette smoking. Neuropsychobiology. 1998; 37(2):112-6. Newton TF, Cook IA, Holschneider DP, Rosenblatt MR, Lindholm JE, Jarvik MM. PMID: 9566277.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    86. Changes in cortical EEG and cholinergic function in response to NGF in rats with nucleus basalis lesions. Brain Res. 1997 Aug 15; 765(2):228-37. Holschneider DP, Leuchter AF, Walton NY, Scremin OU, Treiman DM. PMID: 9313895.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    87. Loss of high-frequency brain electrical response to thiopental administration in Alzheimer's-type dementia. Neuropsychopharmacology. 1997 Apr; 16(4):269-75. Holschneider DP, Leuchter AF, Uijtdehaage SH, Abrams M, Rosenberg-Thompson S. PMID: 9094144.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    88. Beta activity in aging and dementia. Brain Topogr. 1995; 8(2):169-80. Holschneider DP, Leuchter AF. PMID: 8793127.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    89. Capgras' syndrome and psychosis in a patient with tuberous sclerosis. J Neuropsychiatry Clin Neurosci. 1992; 4(3):352-3. Holschneider DP, Szuba MP. PMID: 1498593.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
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