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Zhanghua Chen

Title(s)Assistant Professor of Preventive Medicine
Phone+1 323 442 2109
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    Collapse Biography 
    Collapse Education and Training
    University of Southern California, Los Angeles, CA, USPhDBiostatistics
    Fudan University, Shanghai, ChinaB.S.Clinical Medicine

    Collapse Overview 
    Collapse Overview
    Dr. Zhanghua Chen is an environmental epidemiologist and biostatistician with multidisciplinary expertise in environmental health, biostatistics, epidemiology, clinical medicine, obesity and diabetes pathophysiology, genomics, metabolomics, and data science. She has a strong track record in environmental health research with particular interests in the health effects of early-life environmental exposures in children and adults, the epidemiology of diabetes and obesity, and methods of multi-omics studies.

    Dr. Chen aims to contribute her research to early prevention and treatment of complex diseases. She is creative, collaborative and highly productive. She is establishing a novel research area in environmental epidemiology by leveraging the advanced metabolomics and multi-omics approaches. Dr. Chen is the principal investigator on the NIEHS-supported K99/R00 Pathway to Independence Award: “Metabolomic Signatures Linking Air Pollution, Obesity and Diabetes”. She has also published many papers in well-received medical journals such as Diabetes Care and American Journal of Respiratory and Critical Care Medicine. Her accomplishments in environmental health research have received wide media attention from national and international news agencies, e.g., Reuters and Xinhua News Agency.

    Collapse Research 
    Collapse Research Activities and Funding
    Metabolomic Signatures Linking Air Pollution, Obesity and Diabetes
    NIH/NIEHS R00ES027870Dec 1, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Metabolomic Signatures Linking Air Pollution, Obesity and Diabetes
    NIH/NIEHS K99ES027870Dec 1, 2017 - Nov 30, 2019
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chen Z, Newgard CB, Kim JS, IIkayeva O, Alderete TL, Thomas DC, Berhane K, Breton C, Chatzi L, Bastain TM, McConnell R, Avol E, Lurmann F, Muehlbauer MJ, Hauser ER, Gilliland FD. Near-roadway air pollution exposure and altered fatty acid oxidation among adolescents and young adults - The interplay with obesity. Environ Int. 2019 Sep; 130:104935. PMID: 31238265.
      View in: PubMed
    2. Middeldorp CM, Felix JF, Mahajan A, McCarthy MI. The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects. Eur J Epidemiol. 2019 Mar; 34(3):279-300. PMID: 30887376.
      View in: PubMed
    3. Alderete TL, Jin R, Walker DI, Valvi D, Chen Z, Jones DP, Peng C, Gilliland FD, Berhane K, Conti DV, Goran MI, Chatzi L. Perfluoroalkyl substances, metabolomic profiling, and alterations in glucose homeostasis among overweight and obese Hispanic children: A proof-of-concept analysis. Environ Int. 2019 05; 126:445-453. PMID: 30844580.
      View in: PubMed
    4. Chen Z, Herting MM, Chatzi L, Belcher BR, Alderete TL, McConnell RS, and Gilliland FD.Regional and Traffic-related Air Pollutants Are Associated with Higher Consumption of High Fat and Fast Food among Adolescents. The American Journal of Clinical Nutrition. 2018; 109(1):99-108.
    5. Croteau-Chonka DC, Chen Z, Barnes KC, Barraza-Villarreal A, Celedón JC, Gauderman WJ, Gilliland FD, Krishnan JA, Liu AH, London SJ, Martinez FD, Millstein J, Naureckas ET, Nicolae DL, White SR, Ober C, Weiss ST, Raby BA. Gene Coexpression Networks in Whole Blood Implicate Multiple Interrelated Molecular Pathways in Obesity in People with Asthma. Obesity (Silver Spring). 2018 12; 26(12):1938-1948. PMID: 30358166.
      View in: PubMed
    6. Contreras ZA, Chen Z, Roumeliotaki T, Annesi-Maesano I, Baïz N, von Berg A, Bergström A, Crozier S, Duijts L, Ekström S, Eller E, Fantini MP, Kjaer HF, Forastiere F, Gerhard B, Gori D, Harskamp-van Ginkel MW, Heinrich J, Iñiguez C, Inskip H, Keil T, Kogevinas M, Lau S, Lehmann I, Maier D, van Meel ER, Mommers M, Murcia M, Porta D, Smit HA, Standl M, Stratakis N, Sunyer J, Thijs C, Torrent M, Vrijkotte TGM, Wijga AH, Berhane K, Gilliland F, Chatzi L. Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts. Eur Respir J. 2018 09; 52(3). PMID: 30209194.
      View in: PubMed
    7. Kim JS, Alderete TL, Chen Z, Lurmann F, Rappaport E, Habre R, Berhane K, Gilliland FD. Longitudinal associations of in utero and early life near-roadway air pollution with trajectories of childhood body mass index. Environ Health. 2018 09 14; 17(1):64. PMID: 30213262.
      View in: PubMed
    8. Waage J, Standl M, Curtin JA, Jessen LE, Thorsen J, Tian C, Schoettler N, Flores C, Abdellaoui A, Ahluwalia TS, Alves AC, Amaral AFS, Antó JM, Arnold A, Barreto-Luis A, Baurecht H, van Beijsterveldt CEM, Bleecker ER, Bonàs-Guarch S, Boomsma DI, Brix S, Bunyavanich S, Burchard EG, Chen Z, Curjuric I, Custovic A, den Dekker HT, Dharmage SC, Dmitrieva J, Duijts L, Ege MJ, Gauderman WJ, Georges M, Gieger C, Gilliland F, Granell R, Gui H, Hansen T, Heinrich J, Henderson J, Hernandez-Pacheco N, Holt P, Imboden M, Jaddoe VWV, Jarvelin MR, Jarvis DL, Jensen KK, Jónsdóttir I, Kabesch M, Kaprio J, Kumar A, Lee YA, Levin AM, Li X, Lorenzo-Diaz F, Melén E, Mercader JM, Meyers DA, Myers R, Nicolae DL, Nohr EA, Palviainen T, Paternoster L, Pennell CE, Pershagen G, Pino-Yanes M, Probst-Hensch NM, Rüschendorf F, Simpson A, Stefansson K, Sunyer J, Sveinbjornsson G, Thiering E, Thompson PJ, Torrent M, Torrents D, Tung JY, Wang CA, Weidinger S, Weiss S, Willemsen G, Williams LK, Ober C, Hinds DA, Ferreira MA, Bisgaard H, Strachan DP, Bønnelykke K. Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. Nat Genet. 2018 08; 50(8):1072-1080. PMID: 30013184.
      View in: PubMed
    9. Alderete TL, Chen Z, Toledo-Corral CM, Contreras ZA, Kim JS, Habre R, Chatzi L, Bastain T, Breton CV, Gilliland FD. Ambient and Traffic-Related Air Pollution Exposures as Novel Risk Factors for Metabolic Dysfunction and Type 2 Diabetes. Curr Epidemiol Rep. 2018 Jun; 5(2):79-91. PMID: 30319933.
      View in: PubMed
    10. Alderete TL, Jones RB, Chen Z, Kim JS, Habre R, Lurmann F, Gilliland FD, Goran MI. Exposure to traffic-related air pollution and the composition of the gut microbiota in overweight and obese adolescents. Environ Res. 2018 02; 161:472-478. PMID: 29220800.
      View in: PubMed
    11. Herting MM, Gautam P, Chen Z, Mezher A, Vetter NC. Test-retest reliability of longitudinal task-based fMRI: Implications for developmental studies. Dev Cogn Neurosci. 2018 10; 33:17-26. PMID: 29158072.
      View in: PubMed
    12. Chen Z, Salam MT, Alderete TL, Habre R, Bastain TM, Berhane K, Gilliland FD. Effects of Childhood Asthma on the Development of Obesity among School-aged Children. Am J Respir Crit Care Med. 2017 05 01; 195(9):1181-1188. PMID: 28103443.
      View in: PubMed
    13. Alderete TL, Habre R, Toledo-Corral CM, Berhane K, Chen Z, Lurmann FW, Weigensberg MJ, Goran MI, Gilliland FD. Longitudinal Associations Between Ambient Air Pollution With Insulin Sensitivity, ß-Cell Function, and Adiposity in Los Angeles Latino Children. Diabetes. 2017 07; 66(7):1789-1796. PMID: 28137791.
      View in: PubMed
    14. Baydur A, Tran A, Pallickal L, Fong M, Grazette L, Chowdhury S, and Chen Z.. Breathing Intolerance Index (BIT) and its Relation to Exercise Data: Noninvasive Assessment of Inspiratory Muscle Endurance during Rest and Exercise in Patients with Chronic Obstructive Pulmonary Disease and Cardiovascular Disorders. Insight Medical Publishing Journals. 2016; 2(1).
    15. Chen Z, Salam MT, Toledo-Corral C, Watanabe RM, Xiang AH, Buchanan TA, Habre R, Bastain TM, Lurmann F, Wilson JP, Trigo E, Gilliland FD. Ambient Air Pollutants Have Adverse Effects on Insulin and Glucose Homeostasis in Mexican Americans. Diabetes Care. 2016 Apr; 39(4):547-54. PMID: 26868440.
      View in: PubMed
    16. Zheng T, Chen Z, Lu Y. Influence factors of estimation errors for total corneal astigmatism using keratometric astigmatism in patients before cataract surgery. J Cataract Refract Surg. 2016 Jan; 42(1):84-94. PMID: 26948782.
      View in: PubMed
    17. Chen Z, Salam MT, Karim R, Toledo-Corral CM, Watanabe RM, Xiang AH, Buchanan TA, Habre R, Bastain TM, Lurmann F, Taher M, Wilson JP, Trigo E, Gilliland FD. Living near a freeway is associated with lower bone mineral density among Mexican Americans. Osteoporos Int. 2015 Jun; 26(6):1713-21. PMID: 25677718.
      View in: PubMed
    18. Chen Z, Salam MT, Eckel SP, Breton CV, Gilliland FD. Chronic effects of air pollution on respiratory health in Southern California children: findings from the Southern California Children's Health Study. J Thorac Dis. 2015 Jan; 7(1):46-58. PMID: 25694817.
      View in: PubMed
    19. Chen Z, Watanabe RM, Stram DO, Buchanan TA, Xiang AH. High calorie intake is associated with worsening insulin resistance and ß-cell function in Hispanic women after gestational diabetes mellitus. Diabetes Care. 2014 Dec; 37(12):3294-300. PMID: 25404660.
      View in: PubMed
    20. Chen Z, Pereira MA, Seielstad M, Koh WP, Tai ES, Teo YY, Liu J, Hsu C, Wang R, Odegaard AO, Thyagarajan B, Koratkar R, Yuan JM, Gross MD, Stram DO. Joint effects of known type 2 diabetes susceptibility loci in genome-wide association study of Singapore Chinese: the Singapore Chinese health study. PLoS One. 2014; 9(2):e87762. PMID: 24520337.
      View in: PubMed
    21. Baydur A and Chen Z.. Breathing Intolerance Index in COPD and Obesity: A Comparative Observational Study. Open Journal of Respiratory Diseases. 2013; 3(3).
    22. Chen Z, Black MH, Watanabe RM, Trigo E, Takayanagi M, Lawrence JM, Buchanan TA, Xiang AH. Self-reported physical activity is associated with ß-cell function in Mexican American adults. Diabetes Care. 2013 Mar; 36(3):638-44. PMID: 23223346.
      View in: PubMed
    23. Baydur A, Vigen C, Chen Z. Expiratory Flow Limitation in Obstructive Sleep Apnea and COPD: A Quantitative Method to Detect Pattern Differences Using the Negative Expiratory Pressure Technique. Open Respir Med J. 2012; 6:111-20. PMID: 23166569.
      View in: PubMed