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Sandrah Proctor Eckel, PhD

Title(s)Associate Professor of Preventive Medicine
Phone+1 323 442 2030
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    Collapse Biography 
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    Johns Hopkins Bloomberg School of Public Health, Baltimore, MDPhD2009Biostatistics

    Collapse Overview 
    Collapse Overview
    I am an Assistant Professor in the Division of Biostatistics of the Department of Preventive Medicine at the University of Southern California (USC). My work focuses on on statistical methods and applications in environmental epidemiology and exhaled breath biomarkers. I lead an NIEHS-funded R01 on statisical methods for exhaled nitric oxide and I lead the statistical group working on methods for sensor-based, integrated health monitoring systems for measuring environmental, physiological, and behavioral factors in epidemiological studies of asthma in children.

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    Statistical methods for exhaled breath biomarkers in environmental epidemiology
    NIH/NIEHS R01ES027860Sep 30, 2017 - Jun 30, 2020
    Role: Principal Investigator
    Pediatric Research using Integrated Sensor Monitoring Systems (PRISMS): Data and Software Coordination and Integration Center (DSCIC)
    NIH/NIBIB U24EB021996Sep 30, 2015 - Sep 29, 2019
    Role: Multiple Principal Investigator
    Methods for modeling air pollution effects on exhaled biomarkers
    NIH/NIEHS K22ES022987Aug 15, 2013 - Jul 31, 2016
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Jo H, Eckel SP, Chen JC, Cockburn M, Martinez MP, Chow T, Lurmann F, Funk WE, McConnell R, Xiang AH. Associations of gestational diabetes mellitus with residential air pollution exposure in a large Southern California pregnancy cohort. Environ Int. 2019 Jun 21; 130:104933. PMID: 31234004.
      View in: PubMed
    2. Bastain TM, Chavez T, Habre R, Girguis MS, Grubbs B, Toledo-Corral C, Amadeus M, Farzan SF, Al-Marayati L, Lerner D, Noya D, Quimby A, Twogood S, Wilson M, Chatzi L, Cousineau M, Berhane K, Eckel SP, Lurmann F, Johnston J, Dunton GF, Gilliland F, Breton C. Study Design, Protocol and Profile of the Maternal And Developmental Risks from Environmental and Social Stressors (MADRES) Pregnancy Cohort: a Prospective Cohort Study in Predominantly Low-Income Hispanic Women in Urban Los Angeles. BMC Pregnancy Childbirth. 2019 May 30; 19(1):189. PMID: 31146718.
      View in: PubMed
    3. Deng H, Urman R, Gilliland FD, Eckel SP. Understanding the importance of key risk factors in predicting chronic bronchitic symptoms using a machine learning approach. BMC Med Res Methodol. 2019 Mar 29; 19(1):70. PMID: 30925901.
      View in: PubMed
    4. O'Connor SG, Habre R, Bastain TM, Toledo-Corral CM, Gilliland FD, Eckel SP, Cabison J, Naya CH, Farzan SF, Chu D, Chavez TA, Breton CV, Dunton GF. Within-subject effects of environmental and social stressors on pre- and post-partum obesity-related biobehavioral responses in low-income Hispanic women: protocol of an intensive longitudinal study. BMC Public Health. 2019 Feb 28; 19(1):253. PMID: 30819155.
      View in: PubMed
    5. Li K, Habre R, Deng H, Urman R, Morrison J, Gilliland FD, Ambite JL, Stripelis D, Chiang YY, Lin Y, Bui AA, King C, Hosseini A, Vliet EV, Sarrafzadeh M, Eckel SP. Applying Multivariate Segmentation Methods to Human Activity Recognition From Wearable Sensors' Data. JMIR Mhealth Uhealth. 2019 Feb 07; 7(2):e11201. PMID: 30730297.
      View in: PubMed
    6. Howe CG, Eckel SP, Habre R, Girguis MS, Gao L, Lurmann FW, Gilliland FD, Breton CV. Association of Prenatal Exposure to Ambient and Traffic-Related Air Pollution With Newborn Thyroid Function: Findings From the Children's Health Study. JAMA Netw Open. 2018 Sep 07; 1(5):e182172. PMID: 30646156.
      View in: PubMed
    7. Urman R, Eckel S, Deng H, Berhane K, Avol E, Lurmann F, McConnell R, Gilliland F. RISK EFFECTS OF NEAR-ROADWAY POLLUTANTS AND ASTHMA STATUS ON BRONCHITIC SYMPTOMS IN CHILDREN. Environ Epidemiol. 2018 Jun; 2(2). PMID: 30519674.
      View in: PubMed
    8. Habre R, Zhou H, Eckel SP, Enebish T, Fruin S, Bastain T, Rappaport E, Gilliland F. Short-term effects of airport-associated ultrafine particle exposure on lung function and inflammation in adults with asthma. Environ Int. 2018 09; 118:48-59. PMID: 29800768.
      View in: PubMed
    9. Yani MS, Wondolowski JH, Eckel SP, Kulig K, Fisher BE, Gordon JE, Kutch JJ. Distributed representation of pelvic floor muscles in human motor cortex. Sci Rep. 2018 May 08; 8(1):7213. PMID: 29740105.
      View in: PubMed
    10. Kerin T, Volk H, Li W, Lurmann F, Eckel S, McConnell R, Hertz-Picciotto I. Association Between Air Pollution Exposure, Cognitive and Adaptive Function, and ASD Severity Among Children with Autism Spectrum Disorder. J Autism Dev Disord. 2018 01; 48(1):137-150. PMID: 28921105.
      View in: PubMed
    11. Lin Y, Stripelis D, Chiang YY, Ambite JL, Habre R, Pan F, Eckel SP. Mining Public Datasets for Modeling Intra-City PM2.5 Concentrations at a Fine Spatial Resolution. Proc ACM SIGSPATIAL Int Conf Adv Inf. 2017 Nov; 2017. PMID: 29527599.
      View in: PubMed
    12. Zhang Y, Salam MT, Berhane K, Eckel SP, Rappaport EB, Linn WS, Habre R, Bastain TM, Gilliland FD. Genetic and epigenetic susceptibility of airway inflammation to PM2.5 in school children: new insights from quantile regression. Environ Health. 2017 08 18; 16(1):88. PMID: 28821285.
      View in: PubMed
    13. Muchmore P, Rappaport EB, Eckel SP. Bayesian estimation of physiological parameters governing a dynamic two-compartment model of exhaled nitric oxide. Physiol Rep. 2017 Aug; 5(15). PMID: 28774947.
      View in: PubMed
    14. Deng H, Eckel SP, Liu L, Lurmann FW, Cockburn MG, Gilliland FD. Particulate matter air pollution and liver cancer survival. Int J Cancer. 2017 08 15; 141(4):744-749. PMID: 28589567.
      View in: PubMed
    15. Stripelis D, Ambite JL, Chiang YY, Eckel SP, Habre R. A Scalable Data Integration and Analysis Architecture for Sensor Data of Pediatric Asthma. Proc Int Conf Data Eng. 2017 Apr; 2017:1407-1408. PMID: 29731601.
      View in: PubMed
    16. Molshatski N, Eckel SP. Optimal flow rate sampling designs for studies with extended exhaled nitric oxide analysis. J Breath Res. 2017 Feb 22; 11(1):016012. PMID: 28104897.
      View in: PubMed
    17. Eckel SP, Cockburn M, Shu YH, Deng H, Lurmann FW, Liu L, Gilliland FD. Air pollution affects lung cancer survival. Thorax. 2016 10; 71(10):891-8. PMID: 27491839.
      View in: PubMed
    18. Salam MT, Lin PC, Eckel SP, Gauderman WJ, Gilliland FD. Correction: Inducible Nitric Oxide Synthase Promoter Haplotypes and Residential Traffic-Related Air Pollution Jointly Influence Exhaled Nitric Oxide Level in Children. PLoS One. 2016; 11(5):e0155567. PMID: 27159012.
      View in: PubMed
    19. Jakacki RI, Cohen KJ, Buxton A, Krailo MD, Burger PC, Rosenblum MK, Brat DJ, Hamilton RL, Eckel SP, Zhou T, Lavey RS, Pollack IF. Phase 2 study of concurrent radiotherapy and temozolomide followed by temozolomide and lomustine in the treatment of children with high-grade glioma: a report of the Children's Oncology Group ACNS0423 study. Neuro Oncol. 2016 10; 18(10):1442-50. PMID: 27006176; PMCID: PMC5035517 [Available on 10/01/17].
    20. Eckel SP, Zhang Z, Habre R, Rappaport EB, Linn WS, Berhane K, Zhang Y, Bastain TM, Gilliland FD. Traffic-related air pollution and alveolar nitric oxide in southern California children. Eur Respir J. 2016 05; 47(5):1348-56. PMID: 26797034.
      View in: PubMed
    21. Salam MT, Lin PC, Eckel SP, Gauderman WJ, Gilliland FD. Inducible Nitric Oxide Synthase Promoter Haplotypes and Residential Traffic-Related Air Pollution Jointly Influence Exhaled Nitric Oxide Level in Children. PLoS One. 2015; 10(12):e0145363. PMID: 26714306; PMCID: PMC4695093.
    22. Zhang Y, Berhane K, Eckel SP, Salam MT, Linn WS, Rappaport EB, Bastain TM, Gilliland FD. Determinants of Children's Exhaled Nitric Oxide: New Insights from Quantile Regression. PLoS One. 2015; 10(7):e0130505. PMID: 26214692.
      View in: PubMed
    23. Kim HB, Eckel SP, Kim JH, Gilliland FD. Exhaled NO: Determinants and Clinical Application in Children With Allergic Airway Disease. Allergy Asthma Immunol Res. 2016 Jan; 8(1):12-21. PMID: 26540497.
      View in: PubMed
    24. Chintagumpala M, Eckel SP, Krailo M, Morris M, Adesina A, Packer R, Lau C, Gajjar A. A pilot study using carboplatin, vincristine, and temozolomide in children with progressive/symptomatic low-grade glioma: a Children's Oncology Group study†. Neuro Oncol. 2015 Aug; 17(8):1132-8. PMID: 25854526.
      View in: PubMed
    25. Chen Z, Salam MT, Eckel SP, Breton CV, Gilliland FD. Chronic effects of air pollution on respiratory health in Southern California children: findings from the Southern California Children's Health Study. J Thorac Dis. 2015 Jan; 7(1):46-58. PMID: 25694817.
      View in: PubMed
    26. Roy A, Gong J, Thomas DC, Zhang J, Kipen HM, Rich DQ, Zhu T, Huang W, Hu M, Wang G, Wang Y, Zhu P, Lu SE, Ohman-Strickland P, Diehl SR, Eckel SP. The cardiopulmonary effects of ambient air pollution and mechanistic pathways: a comparative hierarchical pathway analysis. PLoS One. 2014; 9(12):e114913. PMID: 25502951.
      View in: PubMed
    27. Eckel SP, Linn WS, Salam MT, Bastain TM, Zhang Y, Rappaport EB, Liu M, Berhane K. Spirometry effects on conventional and multiple flow exhaled nitric oxide in children. J Asthma. 2015 Mar; 52(2):198-204. PMID: 25134783.
      View in: PubMed
    28. Berhane K, Zhang Y, Salam MT, Eckel SP, Linn WS, Rappaport EB, Bastain TM, Lurmann F, Gilliland FD. Longitudinal effects of air pollution on exhaled nitric oxide: the Children's Health Study. Occup Environ Med. 2014 Jul; 71(7):507-13. PMID: 24696513.
      View in: PubMed
    29. Eckel SP, Baumbach J, Hauschild AC. On the importance of statistics in breath analysis--hope or curse? J Breath Res. 2014 Mar; 8(1):012001. PMID: 24565974.
      View in: PubMed
    30. Hricko A, Rowland G, Eckel S, Logan A, Taher M, Wilson J. Global trade, local impacts: lessons from California on health impacts and environmental justice concerns for residents living near freight rail yards. Int J Environ Res Public Health. 2014 Feb 10; 11(2):1914-41. PMID: 24518649.
      View in: PubMed
    31. Eckel SP, Linn WS, Berhane K, Rappaport EB, Salam MT, Zhang Y, Gilliland FD. Estimation of parameters in the two-compartment model for exhaled nitric oxide. PLoS One. 2014; 9(1):e85471. PMID: 24465571.
      View in: PubMed
    32. van der Valk RJ, Duijts L, Timpson NJ, Salam MT, Standl M, Curtin JA, Genuneit J, Kerhof M, Kreiner-Møller E, Cáceres A, Gref A, Liang LL, Taal HR, Bouzigon E, Demenais F, Nadif R, Ober C, Thompson EE, Estrada K, Hofman A, Uitterlinden AG, van Duijn C, Rivadeneira F, Li X, Eckel SP, Berhane K, Gauderman WJ, Granell R, Evans DM, St Pourcain B, McArdle W, Kemp JP, Smith GD, Tiesler CM, Flexeder C, Simpson A, Murray CS, Fuchs O, Postma DS, Bønnelykke K, Torrent M, Andersson M, Sleiman P, Hakonarson H, Cookson WO, Moffatt MF, Paternoster L, Melén E, Sunyer J, Bisgaard H, Koppelman GH, Ege M, Custovic A, Heinrich J, Gilliland FD, Henderson AJ, Jaddoe VW, de Jongste JC. Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. J Allergy Clin Immunol. 2014 Jul; 134(1):46-55. PMID: 24315451.
      View in: PubMed
    33. Linn WS, Rappaport EB, Eckel SP, Berhane KT, Zhang Y, Salam MT, Bastain TM, Gilliland FD. Multiple-flow exhaled nitric oxide, allergy, and asthma in a population of older children. Pediatr Pulmonol. 2013 Sep; 48(9):885-96. PMID: 23687084.
      View in: PubMed
    34. Eckel SP, Salam MT. Single high flow exhaled nitric oxide is an imperfect proxy for distal nitric oxide. Occup Environ Med. 2013 Jul; 70(7):519-20. PMID: 23645622.
      View in: PubMed
    35. Eckel S, Sushkov AO, Lamoreaux SK. Limit on the electron electric dipole moment using paramagnetic ferroelectric Eu0.5Ba0.5TiO3. Phys Rev Lett. 2012 Nov 09; 109(19):193003. PMID: 23215379.
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    36. Hudda N, Eckel SP, Knibbs LD, Sioutas C, Delfino RJ, Fruin SA. Linking In-Vehicle Ultrafine Particle Exposures to On-Road Concentrations. Atmos Environ (1994). 2012 Nov 01; 59:578-586. PMID: 23888122.
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    37. Eckel SP, Louis TA, Chaves PH, Fried LP, Margolis AH. Modification of the association between ambient air pollution and lung function by frailty status among older adults in the Cardiovascular Health Study. Am J Epidemiol. 2012 Aug 01; 176(3):214-23. PMID: 22811494.
      View in: PubMed
    38. Eckel S, Sushkov AO, Lamoreaux SK. Note: A high dynamic range, linear response transimpedance amplifier. Rev Sci Instrum. 2012 Feb; 83(2):026106. PMID: 22380140.
      View in: PubMed
    39. Salam MT, Byun HM, Lurmann F, Breton CV, Wang X, Eckel SP, Gilliland FD. Genetic and epigenetic variations in inducible nitric oxide synthase promoter, particulate pollution, and exhaled nitric oxide levels in children. J Allergy Clin Immunol. 2012 Jan; 129(1):232-9.e1-7. PMID: 22055874; PMCID: PMC3487398.
    40. Eckel SP, Berhane K, Salam MT, Rappaport EB, Linn WS, Bastain TM, Zhang Y, Lurmann F, Avol EL, Gilliland FD. Residential traffic-related pollution exposures and exhaled nitric oxide in the children's health study. Environ Health Perspect. 2011 Oct; 119(10):1472-7. PMID: 21708511.
      View in: PubMed
    41. Eckel SP, Bandeen-Roche K, Chaves PH, Fried LP, Louis TA. Surrogate screening models for the low physical activity criterion of frailty. Aging Clin Exp Res. 2011 Jun; 23(3):209-16. PMID: 21993168; PMCID: PMC3351838.