Jiu-Chiuan Chen, MD, ScD

Title(s)Associate Professor of Preventive Medicine
Phone+1 323 442 2949
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    Collapse Overview
    Jiu-Chiuan (JC) Chen is an Associate Professor of Preventive Medicine. Dr. Chen is a physician-epidemiologist with formal training in Internal Medicine, Environmental and Occupational Medicine, Environmental Health Sciences, and Epidemiology (Clinical, Environmental, and Occupational). Chen brings extensive knowledge in medicine and toxicology together with sophisticated skills in quantitative methods to study environments and chronic disease epidemiology and elucidate the biological underpinnings of environmental influences on human health, in order to reduce the resulting environmental health disparities especially among the vulnerable populations.

    At USC, Chen developed the AirPollBrain Network (Co-PIs: Finch & Chen), with its mission to create a research and education program in environmental neurosciences of brain health during development and aging in urban environments. To study how ambient air pollution exposures affect brain aging including Alzheimer’s disease (AD), Dr. Chen’s research team and their collaborators take the team-sciences approach that integrates state-of-the-art knowledge and tools in neurobiology of AD, population & clinical neuroimaging, mouse brain imaging, neuroinformatics and high-dimensional data analyses, brain vascular biology, inhalation exposure assessment and neurotoxicology, clinical neurology and neurosurgery, cognitive neurosciences and neuropsychology, quantitative psychology, epidemiology of AD, spatial statistics, and air pollution epidemiology.

    These powerful approaches had been expanded to study how urban environmental adversities shape the neurodevelopmental and behavioral trajectories during vulnerable time periods. Chen’s team also pioneers the emerging field of environmental health disparities in AD and related dementias, investigating how environmental stressors and resilience factors interact to shape the socio-geographic disparities in dementia.

    Collapse Research 
    Collapse Research Activities and Funding
    Urban Air Pollution and Alzheimer's Disease: Risk, Heterogeneity, and Mechanisms
    NIH/NIA P01AG055367Jul 1, 2018 - Jun 30, 2023
    Role: Co-Principal Investigator
    Environmental Determinants of Pathological Brain Aging in WHI Memory Studies
    NIH/NIEHS R01ES025888Sep 30, 2016 - Jul 31, 2021
    Role: Principal Investigator
    Alzheimer's Disease & Related Dementias: Geography, Environments, and Mechanisms
    NIH/NIA RF1AG054068Sep 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Regional Neurotoxicity & Early Biomarkers of Air Pollution Effects on Brain Aging
    NIH/NIA R21AG051113Sep 1, 2015 - Apr 30, 2017
    Role: Co-Principal Investigator
    Neurodevelopment in Urban Environments: Role of Exposure to Ambient Air Pollution
    NIH/NIEHS R21ES022369Aug 2, 2013 - Jul 31, 2015
    Role: Principal Investigator
    Environmental Determinants of Cognitive Aging in the WHI Memory Study
    NIH/NIA R01AG033078Mar 15, 2011 - Feb 28, 2015
    Role: Principal Investigator
    Environmental Determinants of Sleep Disturbance: Role of Ambient Air Pollution
    NIH/NHLBI R21HL089422Sep 21, 2007 - Jul 31, 2009
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chen JC, Espeland MA, Brunner RL, Lovato LC, Wallace RB, Leng X, Phillips LS, Robinson JG, Kotchen JM, Johnson KC, Manson JE, Stefanick ML, Sarto GE, Mysiw WJ. Sleep duration, cognitive decline, and dementia risk in older women. Alzheimers Dement. 2016 Jan; 12(1):21-33. PMID: 26086180.
      View in: PubMed