Jiu-Chiuan Chen, MD, ScD

Title(s)Associate Professor of Preventive Medicine
AddressSSB 225P 2001 N. Soto Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 2949
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    Jiu-Chiuan (JC) Chen is an Associate Professor of Preventive Medicine. Dr. Chen is a physician-epidemiologist with formal training in Internal Medicine, Environmental and Occupational Medicine, Environmental Health Sciences, and Epidemiology (Clinical, Environmental, and Occupational). Chen brings extensive knowledge in medicine and toxicology together with sophisticated skills in quantitative methods to study environments and chronic disease epidemiology and elucidate the biological underpinnings of environmental influences on human health, in order to reduce the resulting environmental health disparities especially among the vulnerable populations.

    At USC, Chen developed the AirPollBrain Network (Co-PIs: Finch & Chen), with its mission to create a research and education program in environmental neurosciences of brain health during development and aging in urban environments. To study how ambient air pollution exposures affect brain aging including Alzheimer’s disease (AD), Dr. Chen’s research team and their collaborators take the team-sciences approach that integrates state-of-the-art knowledge and tools in neurobiology of AD, population & clinical neuroimaging, mouse brain imaging, neuroinformatics and high-dimensional data analyses, brain vascular biology, inhalation exposure assessment and neurotoxicology, clinical neurology and neurosurgery, cognitive neurosciences and neuropsychology, quantitative psychology, epidemiology of AD, spatial statistics, and air pollution epidemiology.

    These powerful approaches had been expanded to study how urban environmental adversities shape the neurodevelopmental and behavioral trajectories during vulnerable time periods. Chen’s team also pioneers the emerging field of environmental health disparities in AD and related dementias, investigating how environmental stressors and resilience factors interact to shape the socio-geographic disparities in dementia.

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    Urban Air Pollution and Alzheimer's Disease: Risk, Heterogeneity, and Mechanisms
    NIH/NIA P01AG055367Jul 1, 2018 - Jun 30, 2023
    Role: Co-Principal Investigator
    Environmental Determinants of Pathological Brain Aging in WHI Memory Studies
    NIH/NIEHS R01ES025888Sep 30, 2016 - Jul 31, 2021
    Role: Principal Investigator
    Alzheimer's Disease & Related Dementias: Geography, Environments, and Mechanisms
    NIH/NIA RF1AG054068Sep 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Regional Neurotoxicity & Early Biomarkers of Air Pollution Effects on Brain Aging
    NIH/NIA R21AG051113Sep 1, 2015 - Apr 30, 2017
    Role: Co-Principal Investigator
    Neurodevelopment in Urban Environments: Role of Exposure to Ambient Air Pollution
    NIH/NIEHS R21ES022369Aug 2, 2013 - Jul 31, 2015
    Role: Principal Investigator
    Environmental Determinants of Cognitive Aging in the WHI Memory Study
    NIH/NIA R01AG033078Mar 15, 2011 - Feb 28, 2015
    Role: Principal Investigator
    Environmental Determinants of Sleep Disturbance: Role of Ambient Air Pollution
    NIH/NHLBI R21HL089422Sep 21, 2007 - Jul 31, 2009
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Erythrocyte omega-3 index, ambient fine particle exposure, and brain aging. Neurology. 2020 Aug 25; 95(8):e995-e1007. Chen C, Xun P, Kaufman JD, Hayden KM, Espeland MA, Whitsel EA, Serre ML, Vizuete W, Orchard T, Harris WS, Wang X, Chui HC, Chen JC, He K. PMID: 32669395.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    2. Reduced risk of all-cancer and solid cancer in Taiwanese patients with rheumatoid arthritis treated with etanercept, a TNF-a inhibitor. Medicine (Baltimore). 2017 Feb; 96(7):e6055. Lan JL, Tseng CH, Chen JH, Cheng CF, Liang WM, Tsay GJ. PMID: 28207513.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    3. Randomized comparison of group versus individual educational interventions for pregnant women to reduce their secondhand smoke exposure. Medicine (Baltimore). 2016 Oct; 95(40):e5072. Chi YC, Sha F, Yip PS, Chen JL, Chen YY. PMID: 27749578.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansPHPublic Health
    4. Blood Pressure, Carotid Flow Pulsatility, and the Risk of Stroke: A Community-Based Study. Stroke. 2016 09; 47(9):2262-8. Chuang SY, Cheng HM, Bai CH, Yeh WT, Chen JR, Pan WH. PMID: 27491737.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    5. Increased Risk of Stroke in Patients With Fibromyalgia: A Population-BASED Cohort Study. Medicine (Baltimore). 2016 Feb; 95(8):e2860. Tseng CH, Chen JH, Wang YC, Lin MC, Kao CH. PMID: 26937918.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Diagnostic Arthrocentesis for Suspicion of Gout Is Safe and Well Tolerated. J Rheumatol. 2016 Jan; 43(1):150-3. Taylor WJ, Fransen J, Dalbeth N, Neogi T, Ralph Schumacher H, Brown M, Louthrenoo W, Vazquez-Mellado J, Eliseev M, McCarthy G, Stamp LK, Perez-Ruiz F, Sivera F, Ea HK, Gerritsen M, Scire CA, Cavagna L, Lin C, Chou YY, Tausche AK, da Rocha Castelar-Pinheiro G, Janssen M, Chen JH, Slot O, Cimmino M, Uhlig T, Jansen TL. PMID: 26628602.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    7. An Independent Risk of Gout on the Development of Deep Vein Thrombosis and Pulmonary Embolism: A Nationwide, Population-Based Cohort Study. Medicine (Baltimore). 2015 Dec; 94(51):e2140. Huang CC, Huang PH, Chen JH, Lan JL, Tsay GJ, Lin HY, Tseng CH, Lin CL, Hsu CY. PMID: 26705202.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    8. Effect of Urate-lowering Therapy on the Risk of Cardiovascular Disease and All-cause Mortality in Patients with Gout: A Case-matched Cohort Study. J Rheumatol. 2015 Sep; 42(9):1694-701. Chen JH, Lan JL, Cheng CF, Liang WM, Lin HY, Tsay GJ, Yeh WT, Pan WH. PMID: 26077411.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    9. Sleep duration, cognitive decline, and dementia risk in older women. Alzheimers Dement. 2016 Jan; 12(1):21-33. Chen JC, Espeland MA, Brunner RL, Lovato LC, Wallace RB, Leng X, Phillips LS, Robinson JG, Kotchen JM, Johnson KC, Manson JE, Stefanick ML, Sarto GE, Mysiw WJ. PMID: 26086180.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
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