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Nicholas Mancuso, PhD

Title(s)Assistant Professor of Preventive Medicine
Address2001 N. Soto Street
Health Sciences Campus
Los Angeles CA 90033
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    My research aims to develop novel computational and statistical approaches to understand the genetic etiology of complex diseases. This includes integrating molecular phenotypes (e.g., gene expression, protein abundance) with large-scale genome-wide association studies, characterizing the genetic architecture of complex disease (e.g., rare vs common variation), and quantifying the role of selection in shaping the effect-size distribution for alleles.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Localizing Components of Shared Transethnic Genetic Architecture of Complex Traits from GWAS Summary Data. Am J Hum Genet. 2020 May 13. Shi H, Burch KS, Johnson R, Freund MK, Kichaev G, Mancuso N, Manuel AM, Dong N, Pasaniuc B. PMID: 32442408.
      View in: PubMed   Mentions:    Fields:    
    2. Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms. Cell. 2020 Apr 30; 181(3):745. Walker RL, Ramaswami G, Hartl C, Mancuso N, Gandal MJ, de la Torre-Ubieta L, Pasaniuc B, Stein JL, Geschwind DH. PMID: 32359439.
      View in: PubMed   Mentions:    Fields:    
    3. Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms. Cell. 2020 Apr 16; 181(2):484. Walker RL, Ramaswami G, Hartl C, Mancuso N, Gandal MJ, Torre-Ubieta L, Pasaniuc B, Stein JL, Geschwind DH. PMID: 32302575.
      View in: PubMed   Mentions:    Fields:    
    4. Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms. Cell. 2019 10 17; 179(3):750-771.e22. Walker RL, Ramaswami G, Hartl C, Mancuso N, Gandal MJ, de la Torre-Ubieta L, Pasaniuc B, Stein JL, Geschwind DH. PMID: 31626773.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture. Nat Genet. 2019 08; 51(8):1244-1251. Hou K, Burch KS, Majumdar A, Shi H, Mancuso N, Wu Y, Sankararaman S, Pasaniuc B. PMID: 31358995.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Post genome-wide gene-environment interaction study: The effect of genetically driven insulin resistance on breast cancer risk using Mendelian randomization. PLoS One. 2019; 14(6):e0218917. Jung SY, Mancuso N, Papp J, Sobel E, Zhang ZF. PMID: 31246991.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Integrative analysis of Dupuytren's disease identifies novel risk locus and reveals a shared genetic etiology with BMI. Genet Epidemiol. 2019 09; 43(6):629-645. Major M, Freund MK, Burch KS, Mancuso N, Ng M, Furniss D, Pasaniuc B, Ophoff RA. PMID: 31087417.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. Probabilistic fine-mapping of transcriptome-wide association studies. Nat Genet. 2019 04; 51(4):675-682. Mancuso N, Freund MK, Johnson R, Shi H, Kichaev G, Gusev A, Pasaniuc B. PMID: 30926970.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    9. Opportunities and challenges for transcriptome-wide association studies. Nat Genet. 2019 04; 51(4):592-599. Wainberg M, Sinnott-Armstrong N, Mancuso N, Barbeira AN, Knowles DA, Golan D, Ermel R, Ruusalepp A, Quertermous T, Hao K, Björkegren JLM, Im HK, Pasaniuc B, Rivas MA, Kundaje A. PMID: 30926968.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    10. Genome-Wide Meta-analysis of Gene-Environmental Interaction for Insulin Resistance Phenotypes and Breast Cancer Risk in Postmenopausal Women. Cancer Prev Res (Phila). 2019 01; 12(1):31-42. Jung SY, Mancuso N, Yu H, Papp J, Sobel E, Zhang ZF. PMID: 30327367.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Large-scale transcriptome-wide association study identifies new prostate cancer risk regions. Nat Commun. 2018 10 04; 9(1):4079. Mancuso N, Gayther S, Gusev A, Zheng W, Penney KL, Kote-Jarai Z, Eeles R, Freedman M, Haiman C, Pasaniuc B. PMID: 30287866.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    12. Phenotype-Specific Enrichment of Mendelian Disorder Genes near GWAS Regions across 62 Complex Traits. Am J Hum Genet. 2018 10 04; 103(4):535-552. Freund MK, Burch KS, Shi H, Mancuso N, Kichaev G, Garske KM, Pan DZ, Miao Z, Mohlke KL, Laakso M, Pajukanta P, Pasaniuc B, Arboleda VA. PMID: 30290150.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    13. Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. Nat Genet. 2018 04; 50(4):538-548. Gusev A, Mancuso N, Won H, Kousi M, Finucane HK, Reshef Y, Song L, Safi A, McCarroll S, Neale BM, Ophoff RA, O'Donovan MC, Crawford GE, Geschwind DH, Katsanis N, Sullivan PF, Pasaniuc B, Price AL. PMID: 29632383.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    14. Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum. Nat Commun. 2018 03 21; 9(1):1178. Fejzo MS, Sazonova OV, Sathirapongsasuti JF, Hallgrímsdóttir IB, Vacic V, MacGibbon KW, Schoenberg FP, Mancuso N, Slamon DJ, Mullin PM. PMID: 29563502.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    15. Local Genetic Correlation Gives Insights into the Shared Genetic Architecture of Complex Traits. Am J Hum Genet. 2017 Nov 02; 101(5):737-751. Shi H, Mancuso N, Spendlove S, Pasaniuc B. PMID: 29100087.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    16. Targeted mutagenesis in a human-parasitic nematode. PLoS Pathog. 2017 Oct; 13(10):e1006675. Gang SS, Castelletto ML, Bryant AS, Yang E, Mancuso N, Lopez JB, Pellegrini M, Hallem EA. PMID: 29016680.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    17. A multi-stage genome-wide association study of uterine fibroids in African Americans. Hum Genet. 2017 10; 136(10):1363-1373. Hellwege JN, Jeff JM, Wise LA, Gallagher CS, Wellons M, Hartmann KE, Jones SF, Torstenson ES, Dickinson S, Ruiz-Narváez EA, Rohland N, Allen A, Reich D, Tandon A, Pasaniuc B, Mancuso N, Im HK, Hinds DA, Palmer JR, Rosenberg L, Denny JC, Roden DM, Stewart EA, Morton CC, Kenny EE, Edwards TL, Velez Edwards DR. PMID: 28836065.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    18. Enhanced methods to detect haplotypic effects on gene expression. Bioinformatics. 2017 Aug 01; 33(15):2307-2313. Brown R, Kichaev G, Mancuso N, Boocock J, Pasaniuc B. PMID: 28369161.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Integrating Gene Expression with Summary Association Statistics to Identify Genes Associated with 30 Complex Traits. Am J Hum Genet. 2017 Mar 02; 100(3):473-487. Mancuso N, Shi H, Goddard P, Kichaev G, Gusev A, Pasaniuc B. PMID: 28238358.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    20. The contribution of rare variation to prostate cancer heritability. Nat Genet. 2016 Jan; 48(1):30-5. Mancuso N, Rohland N, Rand KA, Tandon A, Allen A, Quinque D, Mallick S, Li H, Stram A, Sheng X, Kote-Jarai Z, Easton DF, Eeles RA, Le Marchand L, Lubwama A, Stram D, Watya S, Conti DV, Henderson B, Haiman CA, Pasaniuc B, Reich D. PMID: 26569126.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    21. Accurate viral population assembly from ultra-deep sequencing data. Bioinformatics. 2014 Jun 15; 30(12):i329-37. Mangul S, Wu NC, Mancuso N, Zelikovsky A, Sun R, Eskin E. PMID: 24932001.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    22. Reconstruction of viral population structure from next-generation sequencing data using multicommodity flows. BMC Bioinformatics. 2013; 14 Suppl 9:S2. Skums P, Mancuso N, Artyomenko A, Tork B, Mandoiu I, Khudyakov Y, Zelikovsky A. PMID: 23902469.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells