Nicholas Mancuso, PhD

Title(s)Assistant Professor of Population and Public Health Sciences
Address2001 N. Soto Street
Health Sciences Campus
Los Angeles CA 90032
vCardDownload vCard

    Collapse Overview 
    Collapse Overview
    My research aims to develop novel computational and statistical approaches to understand the genetic etiology of complex diseases. This includes integrating molecular phenotypes (e.g., gene expression, protein abundance) with large-scale genome-wide association studies, characterizing the genetic architecture of complex disease (e.g., rare vs common variation), and quantifying the role of selection in shaping the effect-size distribution for alleles.
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Multitrait transcriptome-wide association study (TWAS) tests. Genet Epidemiol. 2021 Jun 03. Feng H, Mancuso N, Pasaniuc B, Kraft P. PMID: 34082479.
      View in: PubMed   Mentions:    Fields:    
    2. A Hierarchical Approach Using Marginal Summary Statistics for Multiple Intermediates in a Mendelian Randomization or Transcriptome Analysis. Am J Epidemiol. 2021 06 01; 190(6):1148-1158. Jiang L, Xu S, Mancuso N, Newcombe PJ, Conti DV. PMID: 33404048.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Leveraging expression from multiple tissues using sparse canonical correlation analysis and aggregate tests improves the power of transcriptome-wide association studies. PLoS Genet. 2021 Apr; 17(4):e1008973. Feng H, Mancuso N, Gusev A, Majumdar A, Major M, Pasaniuc B, Kraft P. PMID: 33831007.
      View in: PubMed   Mentions: 1     Fields:    
    4. Evaluating Polygenic Risk Scores for Breast Cancer in Women of African Ancestry. J Natl Cancer Inst. 2021 Mar 26. Du Z, Gao G, Adedokun B, Ahearn T, Lunetta KL, Zirpoli G, Troester MA, Ruiz-Narváez EA, Haddad SA, Pal Choudhury P, Figueroa J, John EM, Bernstein L, Zheng W, Hu JJ, Ziegler RG, Nyante S, Bandera EV, Ingles SA, Mancuso N, Press MF, Deming SL, Rodriguez-Gil JL, Yao S, Ogundiran TO, Ojengbe O, Bolla MK, Dennis J, Dunning AM, Easton DF, Michailidou K, Pharoah PDP, Sandler DP, Taylor JA, Wang Q, Weinberg CR, Kitahara CM, Blot W, Nathanson KL, Hennis A, Nemesure B, Ambs S, Sucheston-Campbell LE, Bensen JT, Chanock SJ, Olshan AF, Ambrosone CB, Olopade OI, Yarney J, Awuah B, Addai Wiafe B, Conti DV, GBHS Study Team , Palmer JR, Garcia-Closas M, Huo D, Haiman CA. PMID: 33769540.
      View in: PubMed   Mentions:    Fields:    
    5. Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nat Genet. 2021 Mar; 53(3):413. Conti DV, Darst BF, Moss LC, Saunders EJ, Sheng X, Chou A, Schumacher FR, Olama AAA, Benlloch S, Dadaev T, Brook MN, Sahimi A, Hoffmann TJ, Takahashi A, Matsuda K, Momozawa Y, Fujita M, Muir K, Lophatananon A, Wan P, Le Marchand L, Wilkens LR, Stevens VL, Gapstur SM, Carter BD, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Giles GG, Southey MC, MacInnis RJ, Cybulski C, Wokolorczyk D, Lubinski J, Neal DE, Donovan JL, Hamdy FC, Martin RM, Nordestgaard BG, Nielsen SF, Weischer M, Bojesen SE, Røder MA, Iversen P, Batra J, Chambers S, Moya L, Horvath L, Clements JA, Tilley W, Risbridger GP, Gronberg H, Aly M, Szulkin R, Eklund M, Nordström T, Pashayan N, Dunning AM, Ghoussaini M, Travis RC, Key TJ, Riboli E, Park JY, Sellers TA, Lin HY, Albanes D, Weinstein SJ, Mucci LA, Giovannucci E, Lindstrom S, Kraft P, Hunter DJ, Penney KL, Turman C, Tangen CM, Goodman PJ, Thompson IM, Hamilton RJ, Fleshner NE, Finelli A, Parent MÉ, Stanford JL, Ostrander EA, Geybels MS, Koutros S, Freeman LEB, Stampfer M, Wolk A, Håkansson N, Andriole GL, Hoover RN, Machiela MJ, Sørensen KD, Borre M, Blot WJ, Zheng W, Yeboah ED, Mensah JE, Lu YJ, Zhang HW, Feng N, Mao X, Wu Y, Zhao SC, Sun Z, Thibodeau SN, McDonnell SK, Schaid DJ, West CML, Burnet N, Barnett G, Maier C, Schnoeller T, Luedeke M, Kibel AS, Drake BF, Cussenot O, Cancel-Tassin G, Menegaux F, Truong T, Koudou YA, John EM, Grindedal EM, Maehle L, Khaw KT, Ingles SA, Stern MC, Vega A, Gómez-Caamaño A, Fachal L, Rosenstein BS, Kerns SL, Ostrer H, Teixeira MR, Paulo P, Brandão A, Watya S, Lubwama A, Bensen JT, Fontham ETH, Mohler J, Taylor JA, Kogevinas M, Llorca J, Castaño-Vinyals G, Cannon-Albright L, Teerlink CC, Huff CD, Strom SS, Multigner L, Blanchet P, Brureau L, Kaneva R, Slavov C, Mitev V, Leach RJ, Weaver B, Brenner H, Cuk K, Holleczek B, Saum KU, Klein EA, Hsing AW, Kittles RA, Murphy AB, Logothetis CJ, Kim J, Neuhausen SL, Steele L, Ding YC, Isaacs WB, Nemesure B, Hennis AJM, Carpten J, Pandha H, Michael A, De Ruyck K, De Meerleer G, Ost P, Xu J, Razack A, Lim J, Teo SH, Newcomb LF, Lin DW, Fowke JH, Neslund-Dudas C, Rybicki BA, Gamulin M, Lessel D, Kulis T, Usmani N, Singhal S, Parliament M, Claessens F, Joniau S, Van den Broeck T, Gago-Dominguez M, Castelao JE, Martinez ME, Larkin S, Townsend PA, Aukim-Hastie C, Bush WS, Aldrich MC, Crawford DC, Srivastava S, Cullen JC, Petrovics G, Casey G, Roobol MJ, Jenster G, van Schaik RHN, Hu JJ, Sanderson M, Varma R, McKean-Cowdin R, Torres M, Mancuso N, Berndt SI, Van Den Eeden SK, Easton DF, Chanock SJ, Cook MB, Wiklund F, Nakagawa H, Witte JS, Eeles RA, Kote-Jarai Z, Haiman CA. PMID: 33473200.
      View in: PubMed   Mentions: 1     Fields:    
    6. Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nat Genet. 2021 01; 53(1):65-75. Conti DV, Darst BF, Moss LC, Saunders EJ, Sheng X, Chou A, Schumacher FR, Olama AAA, Benlloch S, Dadaev T, Brook MN, Sahimi A, Hoffmann TJ, Takahashi A, Matsuda K, Momozawa Y, Fujita M, Muir K, Lophatananon A, Wan P, Le Marchand L, Wilkens LR, Stevens VL, Gapstur SM, Carter BD, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Giles GG, Southey MC, MacInnis RJ, Cybulski C, Wokolorczyk D, Lubinski J, Neal DE, Donovan JL, Hamdy FC, Martin RM, Nordestgaard BG, Nielsen SF, Weischer M, Bojesen SE, Røder MA, Iversen P, Batra J, Chambers S, Moya L, Horvath L, Clements JA, Tilley W, Risbridger GP, Gronberg H, Aly M, Szulkin R, Eklund M, Nordström T, Pashayan N, Dunning AM, Ghoussaini M, Travis RC, Key TJ, Riboli E, Park JY, Sellers TA, Lin HY, Albanes D, Weinstein SJ, Mucci LA, Giovannucci E, Lindstrom S, Kraft P, Hunter DJ, Penney KL, Turman C, Tangen CM, Goodman PJ, Thompson IM, Hamilton RJ, Fleshner NE, Finelli A, Parent MÉ, Stanford JL, Ostrander EA, Geybels MS, Koutros S, Freeman LEB, Stampfer M, Wolk A, Håkansson N, Andriole GL, Hoover RN, Machiela MJ, Sørensen KD, Borre M, Blot WJ, Zheng W, Yeboah ED, Mensah JE, Lu YJ, Zhang HW, Feng N, Mao X, Wu Y, Zhao SC, Sun Z, Thibodeau SN, McDonnell SK, Schaid DJ, West CML, Burnet N, Barnett G, Maier C, Schnoeller T, Luedeke M, Kibel AS, Drake BF, Cussenot O, Cancel-Tassin G, Menegaux F, Truong T, Koudou YA, John EM, Grindedal EM, Maehle L, Khaw KT, Ingles SA, Stern MC, Vega A, Gómez-Caamaño A, Fachal L, Rosenstein BS, Kerns SL, Ostrer H, Teixeira MR, Paulo P, Brandão A, Watya S, Lubwama A, Bensen JT, Fontham ETH, Mohler J, Taylor JA, Kogevinas M, Llorca J, Castaño-Vinyals G, Cannon-Albright L, Teerlink CC, Huff CD, Strom SS, Multigner L, Blanchet P, Brureau L, Kaneva R, Slavov C, Mitev V, Leach RJ, Weaver B, Brenner H, Cuk K, Holleczek B, Saum KU, Klein EA, Hsing AW, Kittles RA, Murphy AB, Logothetis CJ, Kim J, Neuhausen SL, Steele L, Ding YC, Isaacs WB, Nemesure B, Hennis AJM, Carpten J, Pandha H, Michael A, De Ruyck K, De Meerleer G, Ost P, Xu J, Razack A, Lim J, Teo SH, Newcomb LF, Lin DW, Fowke JH, Neslund-Dudas C, Rybicki BA, Gamulin M, Lessel D, Kulis T, Usmani N, Singhal S, Parliament M, Claessens F, Joniau S, Van den Broeck T, Gago-Dominguez M, Castelao JE, Martinez ME, Larkin S, Townsend PA, Aukim-Hastie C, Bush WS, Aldrich MC, Crawford DC, Srivastava S, Cullen JC, Petrovics G, Casey G, Roobol MJ, Jenster G, van Schaik RHN, Hu JJ, Sanderson M, Varma R, McKean-Cowdin R, Torres M, Mancuso N, Berndt SI, Van Den Eeden SK, Easton DF, Chanock SJ, Cook MB, Wiklund F, Nakagawa H, Witte JS, Eeles RA, Kote-Jarai Z, Haiman CA. PMID: 33398198.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    7. Integrative analyses identify susceptibility genes underlying COVID-19 hospitalization. medRxiv. 2020 Dec 08. Pathak GA, Singh K, Miller-Fleming TW, Wendt F, Ehsan N, Hou K, Johnson R, Lu Z, Gopalan S, Dimbou LY, Mohammadi P, Pasaniuc B, Polimanti R, Davis LK, Mancuso N. PMID: 33330876.
      View in: PubMed   Mentions:
    8. The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study. Front Genet. 2020; 11:540724. Jung SY, Mancuso N, Han S, Zhang ZF. PMID: 33193614.
      View in: PubMed   Mentions:
    9. Localizing Components of Shared Transethnic Genetic Architecture of Complex Traits from GWAS Summary Data. Am J Hum Genet. 2020 06 04; 106(6):805-817. Shi H, Burch KS, Johnson R, Freund MK, Kichaev G, Mancuso N, Manuel AM, Dong N, Pasaniuc B. PMID: 32442408.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    10. Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms. Cell. 2020 Apr 30; 181(3):745. Walker RL, Ramaswami G, Hartl C, Mancuso N, Gandal MJ, de la Torre-Ubieta L, Pasaniuc B, Stein JL, Geschwind DH. PMID: 32359439.
      View in: PubMed   Mentions:    Fields:    
    11. Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms. Cell. 2020 Apr 16; 181(2):484. Walker RL, Ramaswami G, Hartl C, Mancuso N, Gandal MJ, Torre-Ubieta L, Pasaniuc B, Stein JL, Geschwind DH. PMID: 32302575.
      View in: PubMed   Mentions:    Fields:    
    12. Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms. Cell. 2019 10 17; 179(3):750-771.e22. Walker RL, Ramaswami G, Hartl C, Mancuso N, Gandal MJ, de la Torre-Ubieta L, Pasaniuc B, Stein JL, Geschwind DH. PMID: 31626773.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    13. Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture. Nat Genet. 2019 08; 51(8):1244-1251. Hou K, Burch KS, Majumdar A, Shi H, Mancuso N, Wu Y, Sankararaman S, Pasaniuc B. PMID: 31358995.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    14. Post genome-wide gene-environment interaction study: The effect of genetically driven insulin resistance on breast cancer risk using Mendelian randomization. PLoS One. 2019; 14(6):e0218917. Jung SY, Mancuso N, Papp J, Sobel E, Zhang ZF. PMID: 31246991.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    15. Integrative analysis of Dupuytren's disease identifies novel risk locus and reveals a shared genetic etiology with BMI. Genet Epidemiol. 2019 09; 43(6):629-645. Major M, Freund MK, Burch KS, Mancuso N, Ng M, Furniss D, Pasaniuc B, Ophoff RA. PMID: 31087417.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    16. Probabilistic fine-mapping of transcriptome-wide association studies. Nat Genet. 2019 04; 51(4):675-682. Mancuso N, Freund MK, Johnson R, Shi H, Kichaev G, Gusev A, Pasaniuc B. PMID: 30926970.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    17. Opportunities and challenges for transcriptome-wide association studies. Nat Genet. 2019 04; 51(4):592-599. Wainberg M, Sinnott-Armstrong N, Mancuso N, Barbeira AN, Knowles DA, Golan D, Ermel R, Ruusalepp A, Quertermous T, Hao K, Björkegren JLM, Im HK, Pasaniuc B, Rivas MA, Kundaje A. PMID: 30926968.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansCells
    18. Genome-Wide Meta-analysis of Gene-Environmental Interaction for Insulin Resistance Phenotypes and Breast Cancer Risk in Postmenopausal Women. Cancer Prev Res (Phila). 2019 01; 12(1):31-42. Jung SY, Mancuso N, Yu H, Papp J, Sobel E, Zhang ZF. PMID: 30327367.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    19. Large-scale transcriptome-wide association study identifies new prostate cancer risk regions. Nat Commun. 2018 10 04; 9(1):4079. Mancuso N, Gayther S, Gusev A, Zheng W, Penney KL, Kote-Jarai Z, Eeles R, Freedman M, Haiman C, Pasaniuc B, PRACTICAL consortium . PMID: 30287866.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    20. Phenotype-Specific Enrichment of Mendelian Disorder Genes near GWAS Regions across 62 Complex Traits. Am J Hum Genet. 2018 10 04; 103(4):535-552. Freund MK, Burch KS, Shi H, Mancuso N, Kichaev G, Garske KM, Pan DZ, Miao Z, Mohlke KL, Laakso M, Pajukanta P, Pasaniuc B, Arboleda VA. PMID: 30290150.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    21. Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. Nat Genet. 2018 04; 50(4):538-548. Gusev A, Mancuso N, Won H, Kousi M, Finucane HK, Reshef Y, Song L, Safi A, Schizophrenia Working Group of the Psychiatric Genomics Consortium , McCarroll S, Neale BM, Ophoff RA, O'Donovan MC, Crawford GE, Geschwind DH, Katsanis N, Sullivan PF, Pasaniuc B, Price AL. PMID: 29632383.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    22. Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum. Nat Commun. 2018 03 21; 9(1):1178. Fejzo MS, Sazonova OV, Sathirapongsasuti JF, Hallgrímsdóttir IB, Vacic V, MacGibbon KW, Schoenberg FP, Mancuso N, Slamon DJ, Mullin PM, 23andMe Research Team . PMID: 29563502.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    23. Local Genetic Correlation Gives Insights into the Shared Genetic Architecture of Complex Traits. Am J Hum Genet. 2017 Nov 02; 101(5):737-751. Shi H, Mancuso N, Spendlove S, Pasaniuc B. PMID: 29100087.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    24. Targeted mutagenesis in a human-parasitic nematode. PLoS Pathog. 2017 Oct; 13(10):e1006675. Gang SS, Castelletto ML, Bryant AS, Yang E, Mancuso N, Lopez JB, Pellegrini M, Hallem EA. PMID: 29016680.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    25. A multi-stage genome-wide association study of uterine fibroids in African Americans. Hum Genet. 2017 10; 136(10):1363-1373. Hellwege JN, Jeff JM, Wise LA, Gallagher CS, Wellons M, Hartmann KE, Jones SF, Torstenson ES, Dickinson S, Ruiz-Narváez EA, Rohland N, Allen A, Reich D, Tandon A, Pasaniuc B, Mancuso N, Im HK, Hinds DA, Palmer JR, Rosenberg L, Denny JC, Roden DM, Stewart EA, Morton CC, Kenny EE, Edwards TL, Velez Edwards DR. PMID: 28836065.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    26. Enhanced methods to detect haplotypic effects on gene expression. Bioinformatics. 2017 Aug 01; 33(15):2307-2313. Brown R, Kichaev G, Mancuso N, Boocock J, Pasaniuc B. PMID: 28369161.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. Integrating Gene Expression with Summary Association Statistics to Identify Genes Associated with 30 Complex Traits. Am J Hum Genet. 2017 Mar 02; 100(3):473-487. Mancuso N, Shi H, Goddard P, Kichaev G, Gusev A, Pasaniuc B. PMID: 28238358.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    28. The contribution of rare variation to prostate cancer heritability. Nat Genet. 2016 Jan; 48(1):30-5. Mancuso N, Rohland N, Rand KA, Tandon A, Allen A, Quinque D, Mallick S, Li H, Stram A, Sheng X, Kote-Jarai Z, Easton DF, Eeles RA, PRACTICAL consortium , Le Marchand L, Lubwama A, Stram D, Watya S, Conti DV, Henderson B, Haiman CA, Pasaniuc B, Reich D. PMID: 26569126.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    29. Accurate viral population assembly from ultra-deep sequencing data. Bioinformatics. 2014 Jun 15; 30(12):i329-37. Mangul S, Wu NC, Mancuso N, Zelikovsky A, Sun R, Eskin E. PMID: 24932001.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    30. Reconstruction of viral population structure from next-generation sequencing data using multicommodity flows. BMC Bioinformatics. 2013; 14 Suppl 9:S2. Skums P, Mancuso N, Artyomenko A, Tork B, Mandoiu I, Khudyakov Y, Zelikovsky A. PMID: 23902469.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells