Nicholas Mancuso, PhD

Title(s)Associate Professor of Population and Public Health Sciences and Quantitative and Computational Biology
SchoolKeck School of Medicine of Usc
Address1845 N. Soto Street
Health Sciences Campus
Los Angeles CA 90032
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    My research aims to develop novel computational and statistical approaches to understand the genetic etiology of complex diseases. This includes integrating molecular phenotypes (e.g., gene expression, protein abundance) with large-scale genome-wide association studies, characterizing the genetic architecture of complex disease (e.g., rare vs common variation), and quantifying the role of selection in shaping the effect-size distribution for alleles.
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A likelihood-based framework for demographic inference from genealogical trees. Nat Genet. 2025 Apr; 57(4):865-874. Fan C, Cahoon JL, Dinh BL, Ortega-Del Vecchyo D, Huber CD, Edge MD, Mancuso N, Chiang CWK. PMID: 40113903.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    2. Efficient count-based models improve power and robustness for large-scale single-cell eQTL mapping. medRxiv. 2025 Mar 05. Zhang ZE, Kim A, Suboc N, Mancuso N, Gazal S. PMID: 40093202; PMCID: PMC11908335.
      View in: PubMed   Mentions:
    3. The impact of Indigenous American-like ancestry on risk of acute lymphoblastic leukemia in Hispanic/Latino children. medRxiv. 2025 Jan 15. Langie J, Chan TF, Yang W, Kang AY, Morimoto L, Stram DO, Mancuso N, Ma X, Metayer C, Lupo PJ, Rabin KR, Scheurer ME, Wiemels JL, Wiemels JL, Yang JJ, de Smith AJ, Chiang CWK. PMID: 39867407; PMCID: PMC11759616.
      View in: PubMed   Mentions:
    4. Multi-ancestry GWAS of severe pregnancy nausea and vomiting identifies risk loci associated with appetite, insulin signaling, and brain plasticity. Res Sq. 2024 Dec 16. Fejzo M, Wang X, Zöllner J, Pujol-Gualdo N, Laisk T, Estonian Biobank Research Team, Finer S, van Heel DA, Genes & Health Research Team, Brumpton B, Bhatta L, Hveem K, Jasper EA, Velez Edwards DR, Hellwege JN, Edwards T, Jarvik GP, Luo Y, Khan A, MacGibbon K, Gao Y, Ge G, Averbukh I, Soon E, Angelo M, Magnus P, Johansson S, Njølstad PR, Vaudel M, Shu C, Mancuso N. PMID: 39764105; PMCID: PMC11702859.
      View in: PubMed   Mentions:
    5. Multi-ancestry GWAS of severe pregnancy nausea and vomiting identifies risk loci associated with appetite, insulin signaling, and brain plasticity. medRxiv. 2024 Nov 20. Fejzo M, Wang X, Zöllner J, Pujol-Gualdo N, Laisk T, Estonian Biobank Research Team, Finer S, van Heel DA, Genes & Health Research Team, Brumpton B, Bhatta L, Hveem K, Jasper EA, Velez Edwards DR, Hellwege JN, Edwards T, Jarvik GP, Luo Y, Khan A, MacGibbon K, Gao Y, Ge G, Averbukh I, Soon E, Angelo M, Magnus P, Johansson S, Njølstad PR, Vaudel M, Shu C, Mancuso N. PMID: 39606329; PMCID: PMC11601681.
      View in: PubMed   Mentions:
    6. Identification of proteins associated with type 2 diabetes risk in diverse racial and ethnic populations. Diabetologia. 2024 Dec; 67(12):2754-2770. Liu S, Zhu J, Zhong H, Wu C, Xue H, Darst BF, Guo X, Durda P, Tracy RP, Liu Y, Johnson WC, Taylor KD, Manichaikul AW, Goodarzi MO, Gerszten RE, Clish CB, Chen YI, Highland H, Haiman CA, Gignoux CR, Lange L, Conti DV, Raffield LM, Wilkens L, Marchand LL, North KE, Young KL, Loos RJ, Buyske S, Matise T, Peters U, Kooperberg C, Reiner AP, Yu B, Boerwinkle E, Sun Q, Rooney MR, Echouffo-Tcheugui JB, Daviglus ML, Qi Q, Mancuso N, Li C, Deng Y, Manning A, Meigs JB, Rich SS, Rotter JI, Wu L. PMID: 39349773; PMCID: PMC11963907.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Genes with differential expression across ancestries are enriched in ancestry-specific disease effects likely due to gene-by-environment interactions. Am J Hum Genet. 2024 Oct 03; 111(10):2117-2128. Wang J, Zhang Z, Lu Z, Mancuso N, Gazal S. PMID: 39191255; PMCID: PMC11480800.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. Hierarchical joint analysis of marginal summary statistics-Part II: High-dimensional instrumental analysis of omics data. Genet Epidemiol. 2024 Oct; 48(7):291-309. Jiang L, Shen J, Darst BF, Haiman CA, Mancuso N, Conti DV. PMID: 38887957.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Inferring causal cell types of human diseases and risk variants from candidate regulatory elements. medRxiv. 2024 May 18. Kim A, Zhang Z, Legros C, Lu Z, de Smith A, Moore JE, Mancuso N, Gazal S. PMID: 38798383; PMCID: PMC11118635.
      View in: PubMed   Mentions:
    10. Improved multi-ancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk. medRxiv. 2024 Apr 16. Lu Z, Wang X, Carr M, Kim A, Gazal S, Mohammadi P, Wu L, Gusev A, Pirruccello J, Kachuri L, Mancuso N. PMID: 38699369; PMCID: PMC11065034.
      View in: PubMed   Mentions:
    11. Novel breast cancer susceptibility loci under linkage peaks identified in African ancestry consortia. Hum Mol Genet. 2024 04 08; 33(8):687-697. Ochs-Balcom HM, Preus L, Du Z, Elston RC, Teerlink CC, Jia G, Guo X, Cai Q, Long J, Ping J, Li B, Stram DO, Shu XO, Sanderson M, Gao G, Ahearn T, Lunetta KL, Zirpoli G, Troester MA, Ruiz-Narváez EA, Haddad SA, Figueroa J, John EM, Bernstein L, Hu JJ, Ziegler RG, Nyante S, Bandera EV, Ingles SA, Mancuso N, Press MF, Deming SL, Rodriguez-Gil JL, Yao S, Ogundiran TO, Ojengbede O, Bolla MK, Dennis J, Dunning AM, Easton DF, Michailidou K, Pharoah PDP, Sandler DP, Taylor JA, Wang Q, O'Brien KM, Weinberg CR, Kitahara CM, Blot W, Nathanson KL, Hennis A, Nemesure B, Ambs S, Sucheston-Campbell LE, Bensen JT, Chanock SJ, Olshan AF, Ambrosone CB, Olopade OI, Conti DV, Palmer J, García-Closas M, Huo D, Zheng W, Haiman C. PMID: 38263910; PMCID: PMC11000665.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children. Cell Genom. 2024 Apr 10; 4(4):100526. de Smith AJ, Wahlster L, Jeon S, Kachuri L, Black S, Langie J, Cato LD, Nakatsuka N, Chan TF, Xia G, Mazumder S, Yang W, Gazal S, Eng C, Hu D, Burchard EG, Ziv E, Metayer C, Mancuso N, Yang JJ, Ma X, Wiemels JL, Wiemels JL, Yu F, Chiang CWK, Sankaran VG. PMID: 38537633; PMCID: PMC11019360.
      View in: PubMed   Mentions: 6     Fields:    
    13. Large-scale integrative analysis of juvenile idiopathic arthritis for new insight into its pathogenesis. Arthritis Res Ther. 2024 02 10; 26(1):47. Kim D, Song J, Mancuso N, Mangul S, Jung J, Jang W. PMID: 38336809; PMCID: PMC10858498.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. A rigorous benchmarking of alignment-based HLA typing algorithms for RNA-seq data. bioRxiv. 2024 Jan 16. Yu D, Ayyala R, Sadek SH, Chittampalli L, Farooq H, Jung J, Nahid AA, Boldirev G, Jung M, Park S, Nguyen A, Zelikovsky A, Mancuso N, Joo JWJ, Thompson RF, Alachkar H, Mangul S. PMID: 38293199; PMCID: PMC10827116.
      View in: PubMed   Mentions:
    15. Haplotype-aware modeling of cis-regulatory effects highlights the gaps remaining in eQTL data. Nat Commun. 2024 Jan 15; 15(1):522. Ehsan N, Kotis BM, Castel SE, Song EJ, Mancuso N, Mohammadi P. PMID: 38225224; PMCID: PMC10789818.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Novel insight into the etiology of ischemic stroke gained by integrative multiome-wide association study. Hum Mol Genet. 2024 01 07; 33(2):170-181. Jung J, Lu Z, de Smith A, Mancuso N. PMID: 37824084; PMCID: PMC10772041.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    17. Tree-based QTL mapping with expected local genetic relatedness matrices. Am J Hum Genet. 2023 12 07; 110(12):2077-2091. Link V, Schraiber JG, Fan C, Dinh B, Mancuso N, Chiang CWK, Edge MD. PMID: 38065072; PMCID: PMC10716520.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    18. A scalable approach to characterize pleiotropy across thousands of human diseases and complex traits using GWAS summary statistics. Am J Hum Genet. 2023 11 02; 110(11):1863-1874. Zhang Z, Jung J, Kim A, Suboc N, Gazal S, Mancuso N. PMID: 37879338; PMCID: PMC10645558.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    19. Estimating heritability explained by local ancestry and evaluating stratification bias in admixture mapping from summary statistics. Am J Hum Genet. 2023 11 02; 110(11):1853-1862. Chan TF, Rui X, Conti DV, Fornage M, Graff M, Haessler J, Haiman C, Highland HM, Jung SY, Kenny EE, Kooperberg C, Le Marchand L, North KE, Tao R, Wojcik G, Gignoux CR, PAGE Consortium, Chiang CWK, Mancuso N. PMID: 37875120; PMCID: PMC10645552.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    20. SuSiE PCA: A scalable Bayesian variable selection technique for principal component analysis. iScience. 2023 Nov 17; 26(11):108181. Yuan D, Mancuso N. PMID: 37953948; PMCID: PMC10638022.
      View in: PubMed   Mentions:
    21. A likelihood-based framework for demographic inference from genealogical trees. bioRxiv. 2023 Oct 13. Fan C, Cahoon JL, Dinh BL, Ortega-Del Vecchyo D, Huber C, Edge MD, Mancuso N, Chiang CWK. PMID: 37873208; PMCID: PMC10592779.
      View in: PubMed   Mentions: 1  
    22. Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions. J Natl Cancer Inst. 2023 06 08; 115(6):712-732. Lindström S, Wang L, Feng H, Majumdar A, Huo S, Macdonald J, Harrison T, Turman C, Chen H, Mancuso N, Bammler T, Breast Cancer Association Consortium (BCAC), Gallinger S, Gruber SB, Gunter MJ, Le Marchand L, Moreno V, Offit K, Colorectal Transdisciplinary Study (CORECT), Colon Cancer Family Registry Study (CCFR), Genetics And, De Vivo I, O'Mara TA, Spurdle AB, Tomlinson I, Endometrial Cancer Association Consortium (ECAC), Fitzgerald R, Gharahkhani P, Gockel I, Jankowski J, Macgregor S, Schumacher J, Barnholtz-Sloan J, Bondy ML, Houlston RS, Jenkins RB, Melin B, Wrensch M, Brennan P, Christiani DC, Johansson M, Mckay J, Aldrich MC, Amos CI, Landi MT, Tardon A, International Lung Cancer Consortium (ILCCO), Bishop DT, Demenais F, Goldstein AM, Iles MM, Kanetsky PA, Law MH, Ovarian Cancer Association Consortium (OCAC), Amundadottir LT, Stolzenberg-Solomon R, Wolpin BM, Pancreatic Cancer Cohort Consortium (Panscan), Klein A, Petersen G, Risch H, Pancreatic Cancer Case-Control Consortium (Panc4), The PRACTICAL Consortium, Chanock SJ, Purdue MP, Scelo G, Pharoah P, Kar S, Hung RJ, Pasaniuc B, Kraft P. PMID: 36929942; PMCID: PMC10248849.
      View in: PubMed   Mentions: 8     Fields:    
    23. Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy. bioRxiv. 2023 Jun 04. Fejzo M, Rocha N, Cimino I, Lockhart SM, Petry C, Kay RG, Burling K, Barker P, George AL, Yasara N, Premawardhena A, Gong S, Cook E, Rainbow K, Withers DJ, Cortessis V, Mullin PM, MacGibbon KW, Jin E, Kam A, Campbell A, Polasek O, Tzoneva G, Gribble FM, Yeo G, Lam B, Saudek V, Hughes IA, Ong KK, Perry J, Sutton Cole A, Baumgarten M, Welsh P, Sattar N, Smith G, Charnock Jones DS, Coll AP, Meek CL, Mettananda S, Hayward C, Mancuso N, O'Rahilly S. PMID: 37398065; PMCID: PMC10312505.
      View in: PubMed   Mentions:
    24. twas_sim, a Python-based tool for simulation and power analysis of transcriptome-wide association analysis. Bioinformatics. 2023 05 04; 39(5). Wang X, Lu Z, Bhattacharya A, Pasaniuc B, Mancuso N. PMID: 37099718; PMCID: PMC10172036.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    25. Estimating heritability explained by local ancestry and evaluating stratification bias in admixture mapping from summary statistics. bioRxiv. 2023 Apr 18. Chan TF, Rui X, Conti DV, Fornage M, Graff M, Haessler J, Haiman C, Highland HM, Jung SY, Kenny E, Kooperberg C, Marchland LL, North KE, Tao R, Wojcik G, Gignoux CR, PAGE Consortium, Chiang CWK, Mancuso N. PMID: 37131817; PMCID: PMC10153181.
      View in: PubMed   Mentions:
    26. The motif composition of variable number tandem repeats impacts gene expression. Genome Res. 2023 04; 33(4):511-524. Lu TY, Smaruj PN, Fudenberg G, Mancuso N, Chaisson MJP. PMID: 37037626; PMCID: PMC10234305.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    27. Tree-based QTL mapping with expected local genetic relatedness matrices. bioRxiv. 2023 Apr 08. Link V, Schraiber JG, Fan C, Dinh B, Mancuso N, Chiang CWK, Edge MD. PMID: 37066144; PMCID: PMC10104234.
      View in: PubMed   Mentions:
    28. Novel insight into the etiology of ischemic stroke gained by integrative transcriptome-wide association study. medRxiv. 2023 Mar 31. Jung J, Lu Z, de Smith A, Mancuso N. PMID: 37034585; PMCID: PMC10081428.
      View in: PubMed   Mentions:
    29. A scalable variational approach to characterize pleiotropic components across thousands of human diseases and complex traits using GWAS summary statistics. medRxiv. 2023 Mar 29. Zhang Z, Jung J, Kim A, Suboc N, Gazal S, Mancuso N. PMID: 37034739; PMCID: PMC10081403.
      View in: PubMed   Mentions:
    30. Incorporation of DNA methylation quantitative trait loci (mQTLs) in epigenome-wide association analysis: application to birthweight effects in neonatal whole blood. Clin Epigenetics. 2022 12 01; 14(1):158. Li S, Mancuso N, Metayer C, Ma X, de Smith AJ, Wiemels JL, Wiemels JL. PMID: 36457128; PMCID: PMC9714153.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    31. Investigating DNA methylation as a mediator of genetic risk in childhood acute lymphoblastic leukemia. Hum Mol Genet. 2022 10 28; 31(21):3741-3756. Xu K, Li S, Pandey P, Kang AY, Morimoto LM, Mancuso N, Ma X, Metayer C, Wiemels JL, Wiemels JL, de Smith AJ. PMID: 35717575; PMCID: PMC9616572.
      View in: PubMed   Mentions: 1     Fields:    
    32. Cytomegalovirus proteins, maternal pregnancy cytokines, and their impact on neonatal immune cytokine profiles and acute lymphoblastic leukemogenesis in children. Haematologica. 2022 09 01; 107(9):2266-2270. Wiemels JL, Wiemels JL, Wang R, Zhou M, Hansen H, Gallant R, Jung J, Mancuso N, De Smith AJ, Metayer C, Kogan SC, Ma X. PMID: 35638549; PMCID: PMC9425315.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    33. Multi-ancestry fine-mapping improves precision to identify causal genes in transcriptome-wide association studies. Am J Hum Genet. 2022 08 04; 109(8):1388-1404. Lu Z, Gopalan S, Yuan D, Conti DV, Pasaniuc B, Gusev A, Mancuso N. PMID: 35931050; PMCID: PMC9388396.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    34. Interaction between maternal killer immunoglobulin-like receptors and offspring HLAs and susceptibility of childhood ALL. Blood Adv. 2022 06 28; 6(12):3756-3766. Feng Q, Zhou M, Li S, Morimoto L, Hansen H, Myint SS, Wang R, Metayer C, Kang A, Fear AL, Pappas D, Erlich H, Hollenbach JA, Mancuso N, Trachtenberg E, de Smith AJ, Ma X, Wiemels JL, Wiemels JL. PMID: 35500222; PMCID: PMC9631572.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    35. A genealogical estimate of genetic relationships. Am J Hum Genet. 2022 05 05; 109(5):812-824. Fan C, Mancuso N, Chiang CWK. PMID: 35417677; PMCID: PMC9118131.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    36. Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits. Mol Psychiatry. 2022 03; 27(3):1394-1404. Pathak GA, Singh K, Wendt FR, Fleming TW, Overstreet C, Koller D, Tylee DS, De Angelis F, Cabrera Mendoza B, Levey DF, Koenen KC, Krystal JH, Pietrzak RH, O' Donell C, Gaziano JM, Falcone G, Stein MB, Gelernter J, Pasaniuc B, Mancuso N, Davis LK, Polimanti R. PMID: 35241783; PMCID: PMC9210390.
      View in: PubMed   Mentions: 19     Fields:    
    37. H3K27ac HiChIP in prostate cell lines identifies risk genes for prostate cancer susceptibility. Am J Hum Genet. 2021 12 02; 108(12):2284-2300. Giambartolomei C, Seo JH, Schwarz T, Freund MK, Johnson RD, Spisak S, Baca SC, Gusev A, Mancuso N, Pasaniuc B, Freedman ML. PMID: 34822763; PMCID: PMC8715276.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    38. Genome-wide trans-ethnic meta-analysis identifies novel susceptibility loci for childhood acute lymphoblastic leukemia. Leukemia. 2022 03; 36(3):865-868. Jeon S, de Smith AJ, Li S, Chen M, Chan TF, Muskens IS, Morimoto LM, DeWan AT, Mancuso N, Metayer C, Ma X, Wiemels JL, Wiemels JL, Chiang CWK. PMID: 34750507; PMCID: PMC9075725.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    39. A transcriptome-wide association study identifies novel candidate susceptibility genes for prostate cancer risk. Int J Cancer. 2022 01 01; 150(1):80-90. Liu D, Zhu J, Zhou D, Nikas EG, Mitanis NT, Sun Y, Wu C, Mancuso N, Cox NJ, Wang L, Freedland SJ, Haiman CA, Gamazon ER, Nikas JB, Wu L. PMID: 34520569; PMCID: PMC8595764.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    40. Evaluating Polygenic Risk Scores for Breast Cancer in Women of African Ancestry. J Natl Cancer Inst. 2021 09 04; 113(9):1168-1176. Du Z, Gao G, Adedokun B, Ahearn T, Lunetta KL, Zirpoli G, Troester MA, Ruiz-Narváez EA, Haddad SA, PalChoudhury P, Figueroa J, John EM, Bernstein L, Zheng W, Hu JJ, Ziegler RG, Nyante S, Bandera EV, Ingles SA, Mancuso N, Press MF, Deming SL, Rodriguez-Gil JL, Yao S, Ogundiran TO, Ojengbe O, Bolla MK, Dennis J, Dunning AM, Easton DF, Michailidou K, Pharoah PDP, Sandler DP, Taylor JA, Wang Q, Weinberg CR, Kitahara CM, Blot W, Nathanson KL, Hennis A, Nemesure B, Ambs S, Sucheston-Campbell LE, Bensen JT, Chanock SJ, Olshan AF, Ambrosone CB, Olopade OI, Yarney J, Awuah B, Wiafe-Addai B, Conti DV, GBHS Study Team, Palmer JR, Garcia-Closas M, Huo D, Haiman CA. PMID: 33769540; PMCID: PMC8418423.
      View in: PubMed   Mentions: 31     Fields:    
    41. Correction to: Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes. Genome Med. 2021 Aug 30; 13(1):139. Pan DZ, Miao Z, Comenho C, Rajkumar S, Koka A, Lee SHT, Alvarez M, Kaminska D, Ko A, Sinsheimer JS, Mohlke KL, Mancuso N, Muñoz-Hernandez LL, Herrera-Hernandez M, Tusié-Luna MT, Aguilar-Salinas C, Pietiläinen KH, Pihlajamäki J, Laakso M, Garske KM, Pajukanta P. PMID: 34461981; PMCID: PMC8406603.
      View in: PubMed   Mentions: 1     Fields:    
    42. Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes. Genome Med. 2021 08 02; 13(1):123. Pan DZ, Miao Z, Comenho C, Rajkumar S, Koka A, Lee SHT, Alvarez M, Kaminska D, Ko A, Sinsheimer JS, Mohlke KL, Mancuso N, Muñoz-Hernandez LL, Herrera-Hernandez M, Tusié-Luna MT, Aguilar-Salinas C, Pietiläinen KH, Pihlajamäki J, Laakso M, Garske KM, Pajukanta P. PMID: 34340684; PMCID: PMC8327600.
      View in: PubMed   Mentions: 20     Fields:    
    43. Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization. Nat Commun. 2021 07 27; 12(1):4569. Pathak GA, Singh K, Miller-Fleming TW, Wendt FR, Ehsan N, Hou K, Johnson R, Lu Z, Gopalan S, Yengo L, Mohammadi P, Pasaniuc B, Polimanti R, Davis LK, Mancuso N. PMID: 34315903; PMCID: PMC8316582.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    44. Multitrait transcriptome-wide association study (TWAS) tests. Genet Epidemiol. 2021 09; 45(6):563-576. Feng H, Mancuso N, Pasaniuc B, Kraft P. PMID: 34082479.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    45. A Hierarchical Approach Using Marginal Summary Statistics for Multiple Intermediates in a Mendelian Randomization or Transcriptome Analysis. Am J Epidemiol. 2021 06 01; 190(6):1148-1158. Jiang L, Xu S, Mancuso N, Newcombe PJ, Conti DV. PMID: 33404048; PMCID: PMC8521785.
      View in: PubMed   Mentions: 2     Fields:    
    46. Leveraging expression from multiple tissues using sparse canonical correlation analysis and aggregate tests improves the power of transcriptome-wide association studies. PLoS Genet. 2021 04; 17(4):e1008973. Feng H, Mancuso N, Gusev A, Majumdar A, Major M, Pasaniuc B, Kraft P. PMID: 33831007; PMCID: PMC8057593.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    47. Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nat Genet. 2021 Mar; 53(3):413. Conti DV, Darst BF, Moss LC, Saunders EJ, Sheng X, Chou A, Schumacher FR, Olama AAA, Benlloch S, Dadaev T, Brook MN, Sahimi A, Hoffmann TJ, Takahashi A, Matsuda K, Momozawa Y, Fujita M, Muir K, Lophatananon A, Wan P, Le Marchand L, Wilkens LR, Stevens VL, Gapstur SM, Carter BD, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Giles GG, Southey MC, MacInnis RJ, Cybulski C, Wokolorczyk D, Lubinski J, Neal DE, Donovan JL, Hamdy FC, Martin RM, Nordestgaard BG, Nielsen SF, Weischer M, Bojesen SE, Røder MA, Iversen P, Batra J, Chambers S, Moya L, Horvath L, Clements JA, Tilley W, Risbridger GP, Gronberg H, Aly M, Szulkin R, Eklund M, Nordström T, Pashayan N, Dunning AM, Ghoussaini M, Travis RC, Key TJ, Riboli E, Park JY, Sellers TA, Lin HY, Albanes D, Weinstein SJ, Mucci LA, Giovannucci E, Lindstrom S, Kraft P, Hunter DJ, Penney KL, Turman C, Tangen CM, Goodman PJ, Thompson IM, Hamilton RJ, Fleshner NE, Finelli A, Parent MÉ, Stanford JL, Ostrander EA, Geybels MS, Koutros S, Freeman LEB, Stampfer M, Wolk A, Håkansson N, Andriole GL, Hoover RN, Machiela MJ, Sørensen KD, Borre M, Blot WJ, Zheng W, Yeboah ED, Mensah JE, Lu YJ, Zhang HW, Feng N, Mao X, Wu Y, Zhao SC, Sun Z, Thibodeau SN, McDonnell SK, Schaid DJ, West CML, Burnet N, Barnett G, Maier C, Schnoeller T, Luedeke M, Kibel AS, Drake BF, Cussenot O, Cancel-Tassin G, Menegaux F, Truong T, Koudou YA, John EM, Grindedal EM, Maehle L, Khaw KT, Ingles SA, Stern MC, Vega A, Gómez-Caamaño A, Fachal L, Rosenstein BS, Kerns SL, Ostrer H, Teixeira MR, Paulo P, Brandão A, Watya S, Lubwama A, Bensen JT, Fontham ETH, Mohler J, Taylor JA, Kogevinas M, Llorca J, Castaño-Vinyals G, Cannon-Albright L, Teerlink CC, Huff CD, Strom SS, Multigner L, Blanchet P, Brureau L, Kaneva R, Slavov C, Mitev V, Leach RJ, Weaver B, Brenner H, Cuk K, Holleczek B, Saum KU, Klein EA, Hsing AW, Kittles RA, Murphy AB, Logothetis CJ, Kim J, Neuhausen SL, Steele L, Ding YC, Isaacs WB, Nemesure B, Hennis AJM, Carpten J, Pandha H, Michael A, De Ruyck K, De Meerleer G, Ost P, Xu J, Razack A, Lim J, Teo SH, Newcomb LF, Lin DW, Fowke JH, Neslund-Dudas C, Rybicki BA, Gamulin M, Lessel D, Kulis T, Usmani N, Singhal S, Parliament M, Claessens F, Joniau S, Van den Broeck T, Gago-Dominguez M, Castelao JE, Martinez ME, Larkin S, Townsend PA, Aukim-Hastie C, Bush WS, Aldrich MC, Crawford DC, Srivastava S, Cullen JC, Petrovics G, Casey G, Roobol MJ, Jenster G, van Schaik RHN, Hu JJ, Sanderson M, Varma R, McKean-Cowdin R, Torres M, Mancuso N, Berndt SI, Van Den Eeden SK, Easton DF, Chanock SJ, Cook MB, Wiklund F, Nakagawa H, Witte JS, Eeles RA, Kote-Jarai Z, Haiman CA. PMID: 33473200.
      View in: PubMed   Mentions: 4     Fields:    
    48. Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nat Genet. 2021 01; 53(1):65-75. Conti DV, Darst BF, Moss LC, Saunders EJ, Sheng X, Chou A, Schumacher FR, Olama AAA, Benlloch S, Dadaev T, Brook MN, Sahimi A, Hoffmann TJ, Takahashi A, Matsuda K, Momozawa Y, Fujita M, Muir K, Lophatananon A, Wan P, Le Marchand L, Wilkens LR, Stevens VL, Gapstur SM, Carter BD, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Giles GG, Southey MC, MacInnis RJ, Cybulski C, Wokolorczyk D, Lubinski J, Neal DE, Donovan JL, Hamdy FC, Martin RM, Nordestgaard BG, Nielsen SF, Weischer M, Bojesen SE, Røder MA, Iversen P, Batra J, Chambers S, Moya L, Horvath L, Clements JA, Tilley W, Risbridger GP, Gronberg H, Aly M, Szulkin R, Eklund M, Nordström T, Pashayan N, Dunning AM, Ghoussaini M, Travis RC, Key TJ, Riboli E, Park JY, Sellers TA, Lin HY, Albanes D, Weinstein SJ, Mucci LA, Giovannucci E, Lindstrom S, Kraft P, Hunter DJ, Penney KL, Turman C, Tangen CM, Goodman PJ, Thompson IM, Hamilton RJ, Fleshner NE, Finelli A, Parent MÉ, Stanford JL, Ostrander EA, Geybels MS, Koutros S, Freeman LEB, Stampfer M, Wolk A, Håkansson N, Andriole GL, Hoover RN, Machiela MJ, Sørensen KD, Borre M, Blot WJ, Zheng W, Yeboah ED, Mensah JE, Lu YJ, Zhang HW, Feng N, Mao X, Wu Y, Zhao SC, Sun Z, Thibodeau SN, McDonnell SK, Schaid DJ, West CML, Burnet N, Barnett G, Maier C, Schnoeller T, Luedeke M, Kibel AS, Drake BF, Cussenot O, Cancel-Tassin G, Menegaux F, Truong T, Koudou YA, John EM, Grindedal EM, Maehle L, Khaw KT, Ingles SA, Stern MC, Vega A, Gómez-Caamaño A, Fachal L, Rosenstein BS, Kerns SL, Ostrer H, Teixeira MR, Paulo P, Brandão A, Watya S, Lubwama A, Bensen JT, Fontham ETH, Mohler J, Taylor JA, Kogevinas M, Llorca J, Castaño-Vinyals G, Cannon-Albright L, Teerlink CC, Huff CD, Strom SS, Multigner L, Blanchet P, Brureau L, Kaneva R, Slavov C, Mitev V, Leach RJ, Weaver B, Brenner H, Cuk K, Holleczek B, Saum KU, Klein EA, Hsing AW, Kittles RA, Murphy AB, Logothetis CJ, Kim J, Neuhausen SL, Steele L, Ding YC, Isaacs WB, Nemesure B, Hennis AJM, Carpten J, Pandha H, Michael A, De Ruyck K, De Meerleer G, Ost P, Xu J, Razack A, Lim J, Teo SH, Newcomb LF, Lin DW, Fowke JH, Neslund-Dudas C, Rybicki BA, Gamulin M, Lessel D, Kulis T, Usmani N, Singhal S, Parliament M, Claessens F, Joniau S, Van den Broeck T, Gago-Dominguez M, Castelao JE, Martinez ME, Larkin S, Townsend PA, Aukim-Hastie C, Bush WS, Aldrich MC, Crawford DC, Srivastava S, Cullen JC, Petrovics G, Casey G, Roobol MJ, Jenster G, van Schaik RHN, Hu JJ, Sanderson M, Varma R, McKean-Cowdin R, Torres M, Mancuso N, Berndt SI, Van Den Eeden SK, Easton DF, Chanock SJ, Cook MB, Wiklund F, Nakagawa H, Witte JS, Eeles RA, Kote-Jarai Z, Haiman CA. PMID: 33398198; PMCID: PMC8148035.
      View in: PubMed   Mentions: 186     Fields:    
    49. Integrative analyses identify susceptibility genes underlying COVID-19 hospitalization. medRxiv. 2020 Dec 08. Pathak GA, Singh K, Miller-Fleming TW, Wendt FR, Ehsan N, Hou K, Johnson R, Lu Z, Gopalan S, Yengo L, Mohammadi P, Pasaniuc B, Polimanti R, Davis LK, Mancuso N. PMID: 33330876; PMCID: PMC7743085.
      View in: PubMed   Mentions:
    50. The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study. Front Genet. 2020; 11:540724. Jung SY, Mancuso N, Han S, Zhang ZF. PMID: 33193614; PMCID: PMC7525156.
      View in: PubMed   Mentions: 2  
    51. Localizing Components of Shared Transethnic Genetic Architecture of Complex Traits from GWAS Summary Data. Am J Hum Genet. 2020 06 04; 106(6):805-817. Shi H, Burch KS, Johnson R, Freund MK, Kichaev G, Mancuso N, Manuel AM, Dong N, Pasaniuc B. PMID: 32442408; PMCID: PMC7273527.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    52. Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms. Cell. 2020 Apr 30; 181(3):745. Walker RL, Ramaswami G, Hartl C, Mancuso N, Gandal MJ, de la Torre-Ubieta L, Pasaniuc B, Stein JL, Geschwind DH. PMID: 32359439.
      View in: PubMed   Mentions: 11     Fields:    
    53. Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms. Cell. 2020 Apr 16; 181(2):484. Walker RL, Ramaswami G, Hartl C, Mancuso N, Gandal MJ, Torre-Ubieta L, Pasaniuc B, Stein JL, Geschwind DH. PMID: 32302575.
      View in: PubMed   Mentions: 1     Fields:    
    54. Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms. Cell. 2019 10 17; 179(3):750-771.e22. Walker RL, Ramaswami G, Hartl C, Mancuso N, Gandal MJ, de la Torre-Ubieta L, Pasaniuc B, Stein JL, Geschwind DH. PMID: 31626773; PMCID: PMC8963725.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansCells
    55. Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture. Nat Genet. 2019 08; 51(8):1244-1251. Hou K, Burch KS, Majumdar A, Shi H, Mancuso N, Wu Y, Sankararaman S, Pasaniuc B. PMID: 31358995; PMCID: PMC6686906.
      View in: PubMed   Mentions: 30     Fields:    
    56. Post genome-wide gene-environment interaction study: The effect of genetically driven insulin resistance on breast cancer risk using Mendelian randomization. PLoS One. 2019; 14(6):e0218917. Jung SY, Mancuso N, Papp J, Sobel E, Zhang ZF. PMID: 31246991; PMCID: PMC6597082.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    57. Integrative analysis of Dupuytren's disease identifies novel risk locus and reveals a shared genetic etiology with BMI. Genet Epidemiol. 2019 09; 43(6):629-645. Major M, Freund MK, Burch KS, Mancuso N, Ng M, Furniss D, Pasaniuc B, Ophoff RA. PMID: 31087417; PMCID: PMC6699495.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    58. Probabilistic fine-mapping of transcriptome-wide association studies. Nat Genet. 2019 04; 51(4):675-682. Mancuso N, Freund MK, Johnson R, Shi H, Kichaev G, Gusev A, Pasaniuc B. PMID: 30926970; PMCID: PMC6619422.
      View in: PubMed   Mentions: 183     Fields:    Translation:HumansCells
    59. Opportunities and challenges for transcriptome-wide association studies. Nat Genet. 2019 04; 51(4):592-599. Wainberg M, Sinnott-Armstrong N, Mancuso N, Barbeira AN, Knowles DA, Golan D, Ermel R, Ruusalepp A, Quertermous T, Hao K, Björkegren JLM, Im HK, Pasaniuc B, Rivas MA, Kundaje A. PMID: 30926968; PMCID: PMC6777347.
      View in: PubMed   Mentions: 346     Fields:    Translation:HumansCells
    60. Genome-Wide Meta-analysis of Gene-Environmental Interaction for Insulin Resistance Phenotypes and Breast Cancer Risk in Postmenopausal Women. Cancer Prev Res (Phila). 2019 01; 12(1):31-42. Jung SY, Mancuso N, Yu H, Papp J, Sobel E, Zhang ZF. PMID: 30327367.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    61. Phenotype-Specific Enrichment of Mendelian Disorder Genes near GWAS Regions across 62 Complex Traits. Am J Hum Genet. 2018 10 04; 103(4):535-552. Freund MK, Burch KS, Shi H, Mancuso N, Kichaev G, Garske KM, Pan DZ, Miao Z, Mohlke KL, Laakso M, Pajukanta P, Pasaniuc B, Arboleda VA. PMID: 30290150; PMCID: PMC6174356.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    62. Large-scale transcriptome-wide association study identifies new prostate cancer risk regions. Nat Commun. 2018 10 04; 9(1):4079. Mancuso N, Gayther S, Gusev A, Zheng W, Penney KL, Kote-Jarai Z, Eeles R, Freedman M, Haiman C, Pasaniuc B, PRACTICAL consortium. PMID: 30287866; PMCID: PMC6172280.
      View in: PubMed   Mentions: 66     Fields:    
    63. Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. Nat Genet. 2018 04; 50(4):538-548. Gusev A, Mancuso N, Won H, Kousi M, Finucane HK, Reshef Y, Song L, Safi A, Schizophrenia Working Group of the Psychiatric Genomics Consortium, McCarroll S, Neale BM, Ophoff RA, O'Donovan MC, Crawford GE, Geschwind DH, Katsanis N, Sullivan PF, Pasaniuc B, Price AL. PMID: 29632383; PMCID: PMC5942893.
      View in: PubMed   Mentions: 196     Fields:    
    64. Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum. Nat Commun. 2018 03 21; 9(1):1178. Fejzo MS, Sazonova OV, Sathirapongsasuti JF, Hallgrímsdóttir IB, Vacic V, MacGibbon KW, Schoenberg FP, Mancuso N, Slamon DJ, Mullin PM, 23andMe Research Team. PMID: 29563502; PMCID: PMC5862842.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    65. Local Genetic Correlation Gives Insights into the Shared Genetic Architecture of Complex Traits. Am J Hum Genet. 2017 Nov 02; 101(5):737-751. Shi H, Mancuso N, Spendlove S, Pasaniuc B. PMID: 29100087; PMCID: PMC5673668.
      View in: PubMed   Mentions: 116     Fields:    Translation:Humans
    66. Targeted mutagenesis in a human-parasitic nematode. PLoS Pathog. 2017 Oct; 13(10):e1006675. Gang SS, Castelletto ML, Bryant AS, Yang E, Mancuso N, Lopez JB, Pellegrini M, Hallem EA. PMID: 29016680; PMCID: PMC5650185.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimals
    67. A multi-stage genome-wide association study of uterine fibroids in African Americans. Hum Genet. 2017 10; 136(10):1363-1373. Hellwege JN, Jeff JM, Wise LA, Gallagher CS, Wellons M, Hartmann KE, Jones SF, Torstenson ES, Dickinson S, Ruiz-Narváez EA, Rohland N, Allen A, Reich D, Tandon A, Pasaniuc B, Mancuso N, Im HK, Hinds DA, Palmer JR, Rosenberg L, Denny JC, Roden DM, Stewart EA, Morton CC, Kenny EE, Edwards TL, Velez Edwards DR. PMID: 28836065; PMCID: PMC5628188.
      View in: PubMed   Mentions: 26     Fields:    
    68. Enhanced methods to detect haplotypic effects on gene expression. Bioinformatics. 2017 Aug 01; 33(15):2307-2313. Brown R, Kichaev G, Mancuso N, Boocock J, Pasaniuc B. PMID: 28369161; PMCID: PMC5860109.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    69. Integrating Gene Expression with Summary Association Statistics to Identify Genes Associated with 30 Complex Traits. Am J Hum Genet. 2017 Mar 02; 100(3):473-487. Mancuso N, Shi H, Goddard P, Kichaev G, Gusev A, Pasaniuc B. PMID: 28238358; PMCID: PMC5339290.
      View in: PubMed   Mentions: 120     Fields:    
    70. The contribution of rare variation to prostate cancer heritability. Nat Genet. 2016 Jan; 48(1):30-5. Mancuso N, Rohland N, Rand KA, Tandon A, Allen A, Quinque D, Mallick S, Li H, Stram A, Sheng X, Kote-Jarai Z, Easton DF, Eeles RA, PRACTICAL consortium, Le Marchand L, Lubwama A, Stram D, Watya S, Conti DV, Henderson B, Haiman CA, Pasaniuc B, Reich D. PMID: 26569126; PMCID: PMC7534691.
      View in: PubMed   Mentions: 59     Fields:    
    71. Accurate viral population assembly from ultra-deep sequencing data. Bioinformatics. 2014 Jun 15; 30(12):i329-37. Mangul S, Wu NC, Mancuso N, Zelikovsky A, Sun R, Eskin E. PMID: 24932001; PMCID: PMC4058922.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    72. Reconstruction of viral population structure from next-generation sequencing data using multicommodity flows. BMC Bioinformatics. 2013; 14 Suppl 9:S2. Skums P, Mancuso N, Artyomenko A, Tork B, Mandoiu I, Khudyakov Y, Zelikovsky A. PMID: 23902469; PMCID: PMC3698000.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
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