Marlena Fejzo

Title(s)Clinical Assistant Professor of Population and Public Health Sciences in the Center for Genetic Epidemiology
SchoolKeck School of Medicine of Usc
Address1845 N. Soto Street
Health Sciences Campus
Los Angeles CA 90032
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    Marlena Schoenberg Fejzo, Ph.D. is a medical scientist whose research focuses on conditions and diseases that primarily affect women. She received a Ph.D. in Genetics from Harvard University in 1995. Currently she works in the Center for Genetic Epidemiology at the University of Southern California and Materna Biosciences, Inc. She has published peer-reviewed scientific articles on ovarian cancer, breast cancer, multiple sclerosis, and discovered the first genes associated with uterine fibroids, nausea and vomiting of pregnancy, and hyperemesis gravidarum. She is a science advisor and board member for the Hyperemesis Education and Research Foundation.

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    1. Hyperemesis gravidarum theories dispelled by recent research: a paradigm change for better care and outcomes. Trends Mol Med. 2024 Jun; 30(6):530-540. Fejzo MS. PMID: 38782680.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. GDF15 linked to maternal risk of nausea and vomiting during pregnancy. Nature. 2024 Jan; 625(7996):760-767. Fejzo M, Rocha N, Cimino I, Lockhart SM, Petry CJ, Kay RG, Burling K, Barker P, George AL, Yasara N, Premawardhena A, Gong S, Cook E, Rimmington D, Rainbow K, Withers DJ, Cortessis V, Mullin PM, MacGibbon KW, Jin E, Kam A, Campbell A, Polasek O, Tzoneva G, Gribble FM, Yeo GSH, Lam BYH, Saudek V, Hughes IA, Ong KK, Perry JRB, Sutton Cole A, Baumgarten M, Welsh P, Sattar N, Smith GCS, Charnock-Jones DS, Coll AP, Meek CL, Mettananda S, Hayward C, Mancuso N, O'Rahilly S. PMID: 38092039; PMCID: PMC10808057.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    3. Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy. bioRxiv. 2023 Jun 04. Fejzo M, Rocha N, Cimino I, Lockhart SM, Petry C, Kay RG, Burling K, Barker P, George AL, Yasara N, Premawardhena A, Gong S, Cook E, Rainbow K, Withers DJ, Cortessis V, Mullin PM, MacGibbon KW, Jin E, Kam A, Campbell A, Polasek O, Tzoneva G, Gribble FM, Yeo G, Lam B, Saudek V, Hughes IA, Ong KK, Perry J, Sutton Cole A, Baumgarten M, Welsh P, Sattar N, Smith G, Charnock Jones DS, Coll AP, Meek CL, Mettananda S, Hayward C, Mancuso N, O'Rahilly S. PMID: 37398065; PMCID: PMC10312505.
      View in: PubMed   Mentions:
    4. Author's reply. BJOG. 2023 06; 130(7):843-844. Fejzo MS. PMID: 36754579.
      View in: PubMed   Mentions:    Fields:    
    5. Pregnant, miserable, and starving in 21st century America. AJOG Glob Rep. 2023 Feb; 3(1):100141. Fejzo MS, MacGibbon KW, Wisner KL. PMID: 36536797; PMCID: PMC9758489.
      View in: PubMed   Mentions:
    6. Inaccuracies in "Long-term health outcomes of children born to mothers with hyperemesis gravidarum: a systematic review and meta-analysis". Am J Obstet Gynecol. 2022 Nov; 227(5):792. Fejzo MS, MacGibbon KW, Mullin PM. PMID: 35850201.
      View in: PubMed   Mentions:    Fields:    
    7. Patterns of Use and Self-reported Effectiveness of Cannabis for Hyperemesis Gravidarum. Geburtshilfe Frauenheilkd. 2022 May; 82(5):517-527. First OK, MacGibbon KW, Cahill CM, Cooper ZD, Gelberg L, Cortessis VK, Mullin PM, Fejzo MS. PMID: 35528189; PMCID: PMC9076215.
      View in: PubMed   Mentions: 1     Fields:    
    8. Whole-exome sequencing uncovers new variants in GDF15 associated with hyperemesis gravidarum. BJOG. 2022 10; 129(11):1845-1852. Fejzo MS, MacGibbon KW, First O, Quan C, Mullin PM. PMID: 35218128; PMCID: PMC9546032.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    9. HyperEmesis Level Prediction (HELP Score) Identifies Patients with Indicators of Severe Disease: a Validation Study. Geburtshilfe Frauenheilkd. 2021 Jan; 81(1):90-98. MacGibbon KW, Kim S, Mullin PM, Fejzo MS. PMID: 33487669; PMCID: PMC7815331.
      View in: PubMed   Mentions: 3     Fields:    
    10. Analysis in epithelial ovarian cancer identifies KANSL1 as a biomarker and target gene for immune response and HDAC inhibition. Gynecol Oncol. 2021 02; 160(2):539-546. Fejzo MS, Chen HW, Anderson L, McDermott MS, Karlan B, Konecny GE, Slamon DJ. PMID: 33229045.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    11. A core outcome set for hyperemesis gravidarum studies is a small step in the right direction. BJOG. 2020 07; 127(8):993. Fejzo MS. PMID: 32196871.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Nausea and vomiting of pregnancy and hyperemesis gravidarum. Nat Rev Dis Primers. 2019 09 12; 5(1):62. Fejzo MS, Trovik J, Grooten IJ, Sridharan K, Roseboom TJ, Vikanes Å, Painter RC, Mullin PM. PMID: 31515515.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansPHPublic Health
    13. Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality. Geburtshilfe Frauenheilkd. 2019 Apr; 79(4):382-388. Fejzo MS, Fasching PA, Schneider MO, Schwitulla J, Beckmann MW, Schwenke E, MacGibbon KW, Mullin PM. PMID: 31000883; PMCID: PMC6461465.
      View in: PubMed   Mentions: 16     Fields:    
    14. Analysis of neurodevelopmental delay in children exposed in utero to hyperemesis gravidarum reveals increased reporting of autism spectrum disorder. Reprod Toxicol. 2019 03; 84:59-64. Fejzo M, Kam A, Laguna A, MacGibbon K, Mullin P. PMID: 30594672.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    15. Evidence GDF15 Plays a Role in Familial and Recurrent Hyperemesis Gravidarum. Geburtshilfe Frauenheilkd. 2018 Sep; 78(9):866-870. Fejzo MS, Arzy D, Tian R, MacGibbon KW, Mullin PM. PMID: 30258246; PMCID: PMC6138473.
      View in: PubMed   Mentions: 18     Fields:    
    16. Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum. Nat Commun. 2018 03 21; 9(1):1178. Fejzo MS, Sazonova OV, Sathirapongsasuti JF, Hallgrímsdóttir IB, Vacic V, MacGibbon KW, Schoenberg FP, Mancuso N, Slamon DJ, Mullin PM, 23andMe Research Team. PMID: 29563502; PMCID: PMC5862842.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    17. Critique of inaccurate reporting in Edlavitch article on "Publishing negative findings and the challenge of avoiding type II errors in studies of suspect teratogens: Example of a recent ondansetron publication". Reprod Toxicol. 2018 01; 75:144-145. Fejzo MS, MacGibbon KW, Mullin PM. PMID: 29174065.
      View in: PubMed   Mentions:    Fields:    
    18. Measures of depression and anxiety in women with hyperemesis gravidarum are flawed. Evid Based Nurs. 2017 07; 20(3):78-79. Fejzo MS. PMID: 28601805.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    19. Proteasome ubiquitin receptor PSMD4 is an amplification target in breast cancer and may predict sensitivity to PARPi. Genes Chromosomes Cancer. 2017 08; 56(8):589-597. Fejzo MS, Anderson L, Chen HW, Guandique E, Kalous O, Conklin D, Slamon DJ. PMID: 28316110.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    20. Response to the questions submitted by Mr. Reichmann. Reprod Toxicol. 2016 12; 66:123. Fejzo M, MacGibbon K, Mullin P. PMID: 27702680.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Genetic analysis of hyperemesis gravidarum reveals association with intracellular calcium release channel (RYR2). Mol Cell Endocrinol. 2017 01 05; 439:308-316. Fejzo MS, Myhre R, Colodro-Conde L, MacGibbon KW, Sinsheimer JS, Reddy MVPL, Pajukanta P, Nyholt DR, Wright MJ, Martin NG, Engel SM, Medland SE, Magnus P, Mullin PM. PMID: 27663074; PMCID: PMC6464816.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    22. Analysis of pre- and post-pregnancy issues in women with hyperemesis gravidarum. Auton Neurosci. 2017 01; 202:73-78. Tian R, MacGibbon K, Martin B, Mullin P, Fejzo M. PMID: 27460690.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. Ondansetron in pregnancy and risk of adverse fetal outcomes in the United States. Reprod Toxicol. 2016 07; 62:87-91. Fejzo MS, MacGibbon KW, Mullin PM. PMID: 27151373.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    24. Intestinal obstruction is a rare complication of ondansetron exposure in hyperemesis gravidarum. Reprod Toxicol. 2015 Nov; 57:207. Fejzo MS, MacGibbon K, Mullin P. PMID: 26196894.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. ADRM1-amplified metastasis gene in gastric cancer. Genes Chromosomes Cancer. 2015 Aug; 54(8):506-515. Fejzo MS, Anderson L, Chen HW, Anghel A, Zhuo J, Anchoori R, Roden R, Slamon DJ. PMID: 26052681.
      View in: PubMed   Mentions: 16     Fields:    
    26. Neurodevelopmental delay in children exposed in utero to hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol. 2015 Jun; 189:79-84. Fejzo MS, Magtira A, Schoenberg FP, Macgibbon K, Mullin PM. PMID: 25898368.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    27. Psychiatric factors do not affect recurrence risk of hyperemesis gravidarum. J Obstet Gynaecol Res. 2015 Apr; 41(4):512-6. Magtira A, Schoenberg FP, MacGibbon K, Tabsh K, Fejzo MS. PMID: 25345812.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    28. KRAS mutational subtype and copy number predict in vitro response of human pancreatic cancer cell lines to MEK inhibition. Br J Cancer. 2014 Oct 28; 111(9):1788-801. Hamidi H, Lu M, Chau K, Anderson L, Fejzo M, Ginther C, Linnartz R, Zubel A, Slamon DJ, Finn RS. PMID: 25167228; PMCID: PMC4453732.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    29. POSTN/TGFBI-associated stromal signature predicts poor prognosis in serous epithelial ovarian cancer. Gynecol Oncol. 2014 Feb; 132(2):334-42. Karlan BY, Dering J, Walsh C, Orsulic S, Lester J, Anderson LA, Ginther CL, Fejzo M, Slamon D. PMID: 24368280.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    30. Antihistamines and other prognostic factors for adverse outcome in hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol. 2013 Sep; 170(1):71-6. Fejzo MS, Magtira A, Schoenberg FP, MacGibbon K, Mullin P, Romero R, Tabsh K. PMID: 23751910; PMCID: PMC4164298.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    31. Dacomitinib, an irreversible Pan-ErbB inhibitor significantly abrogates growth in head and neck cancer models that exhibit low response to cetuximab. PLoS One. 2013; 8(2):e56112. Ather F, Hamidi H, Fejzo MS, Letrent S, Finn RS, Kabbinavar F, Head C, Wong SG. PMID: 23405260; PMCID: PMC3566064.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    32. Amplification Target ADRM1: Role as an Oncogene and Therapeutic Target for Ovarian Cancer. Int J Mol Sci. 2013 Feb 01; 14(2):3094-109. Fejzo MS, Anderson L, von Euw EM, Kalous O, Avliyakulov NK, Haykinson MJ, Konecny GE, Finn RS, Slamon DJ. PMID: 23377018; PMCID: PMC3588033.
      View in: PubMed   Mentions: 27     Fields:    
    33. No increased risk of psychological/behavioral disorders in siblings of women with hyperemesis gravidarum (HG) unless their mother had HG. J Dev Orig Health Dis. 2012 Oct; 3(5):375-9. Mullin PM, Bray A, Vu V, Schoenberg-Paik F, MacGibbon K, Romero R, Goodwin TM, Fejzo MS. PMID: 25102267.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    34. Hyperemesis gravidarum: it is time to put an end to the misguided theory of a psychiatric etiology. Gen Hosp Psychiatry. 2012 Nov-Dec; 34(6):699-700; author reply 700-1. Fejzo MS, Macgibbon K. PMID: 22898444.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    35. Change in paternity and recurrence of hyperemesis gravidarum. J Matern Fetal Neonatal Med. 2012 Aug; 25(8):1241-5. Fejzo MS, Ching C, Schoenberg FP, Macgibbon K, Romero R, Goodwin TM, Mullin PM. PMID: 22010839; PMCID: PMC3527097.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    36. Risk factors, treatments, and outcomes associated with prolonged hyperemesis gravidarum. J Matern Fetal Neonatal Med. 2012 Jun; 25(6):632-6. Mullin PM, Ching C, Schoenberg F, MacGibbon K, Romero R, Goodwin TM, Fejzo MS. PMID: 21916750; PMCID: PMC3560915.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    37. Prenatal exposure to hyperemesis gravidarum linked to increased risk of psychological and behavioral disorders in adulthood. J Dev Orig Health Dis. 2011 Aug; 2(4):200-4. Mullin PM, Bray A, Schoenberg F, MacGibbon KW, Romero R, Goodwin TM, Fejzo MS. PMID: 25141163.
      View in: PubMed   Mentions: 18     Fields:    
    38. Posttraumatic stress symptoms following pregnancy complicated by hyperemesis gravidarum. J Matern Fetal Neonatal Med. 2011 Nov; 24(11):1307-11. Christodoulou-Smith J, Gold JI, Romero R, Goodwin TM, Macgibbon KW, Mullin PM, Fejzo MS. PMID: 21635201; PMCID: PMC3514078.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    39. Knockdown of ovarian cancer amplification target ADRM1 leads to downregulation of GIPC1 and upregulation of RECK. Genes Chromosomes Cancer. 2011 Jun; 50(6):434-41. Fejzo MS, Ginther C, Dering J, Anderson L, Venkatesan N, Konecny G, Karlan B, Slamon DJ. PMID: 21432940.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    40. Recurrence risk of hyperemesis gravidarum. J Midwifery Womens Health. 2011 Mar-Apr; 56(2):132-6. Fejzo MS, Macgibbon KW, Romero R, Goodwin TM, Mullin PM. PMID: 21429077; PMCID: PMC3077880.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansPHPublic Health
    41. Familial aggregation of hyperemesis gravidarum. Am J Obstet Gynecol. 2011 Mar; 204(3):230.e1-7. Zhang Y, Cantor RM, MacGibbon K, Romero R, Goodwin TM, Mullin PM, Fejzo MS. PMID: 20974461; PMCID: PMC3030697.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    42. Periostin promotes ovarian cancer angiogenesis and metastasis. Gynecol Oncol. 2010 Nov; 119(2):337-44. Zhu M, Fejzo MS, Anderson L, Dering J, Ginther C, Ramos L, Gasson JC, Karlan BY, Slamon DJ. PMID: 20688362.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    43. Lapatinib, a dual EGFR and HER2 kinase inhibitor, selectively inhibits HER2-amplified human gastric cancer cells and is synergistic with trastuzumab in vitro and in vivo. Clin Cancer Res. 2010 Mar 01; 16(5):1509-19. Wainberg ZA, Anghel A, Desai AJ, Ayala R, Luo T, Safran B, Fejzo MS, Hecht JR, Slamon DJ, Finn RS. PMID: 20179222.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    44. Tissue microarrays from frozen tissues-OCT technique. Methods Mol Biol. 2010; 664:73-80. Fejzo MS, Slamon DJ. PMID: 20690054.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    45. Symptoms and pregnancy outcomes associated with extreme weight loss among women with hyperemesis gravidarum. J Womens Health (Larchmt). 2009 Dec; 18(12):1981-7. Fejzo MS, Poursharif B, Korst LM, Munch S, MacGibbon KW, Romero R, Goodwin TM. PMID: 20044860; PMCID: PMC2828197.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    46. Patients with a history of hyperemesis gravidarum have similar symptoms during egg stimulation and develop ovarian hyperstimulation syndrome: case series. Fertil Steril. 2010 Jan; 93(1):267.e9-11. Fejzo MS, Romero R, Goodwin TM. PMID: 19878938; PMCID: PMC2812676.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    47. Comprehensive analysis of 20q13 genes in ovarian cancer identifies ADRM1 as amplification target. Genes Chromosomes Cancer. 2008 Oct; 47(10):873-83. Fejzo MS, Dering J, Ginther C, Anderson L, Ramos L, Walsh C, Karlan B, Slamon DJ. PMID: 18615678.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    48. High prevalence of severe nausea and vomiting of pregnancy and hyperemesis gravidarum among relatives of affected individuals. Eur J Obstet Gynecol Reprod Biol. 2008 Nov; 141(1):13-7. Fejzo MS, Ingles SA, Wilson M, Wang W, MacGibbon K, Romero R, Goodwin TM. PMID: 18752885; PMCID: PMC2660884.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    49. Activity of lapatinib a novel HER2 and EGFR dual kinase inhibitor in human endometrial cancer cells. Br J Cancer. 2008 Mar 25; 98(6):1076-84. Konecny GE, Venkatesan N, Yang G, Dering J, Ginther C, Finn R, Rahmeh M, Fejzo MS, Toft D, Jiang SW, Slamon DJ, Podratz KC. PMID: 18334972; PMCID: PMC2275492.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    50. Secular trends in the treatment of hyperemesis gravidarum. Am J Perinatol. 2008 Mar; 25(3):141-7. Goodwin TM, Poursharif B, Korst LM, MacGibbon KW, Romero R, Fejzo MS. PMID: 18260047.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    51. RIN1 is a breast tumor suppressor gene. Cancer Res. 2007 Dec 15; 67(24):11510-6. Milstein M, Mooser CK, Hu H, Fejzo M, Slamon D, Goodglick L, Dry S, Colicelli J. PMID: 18089779; PMCID: PMC2950063.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    52. The psychosocial burden of hyperemesis gravidarum. J Perinatol. 2008 Mar; 28(3):176-81. Poursharif B, Korst LM, Fejzo MS, MacGibbon KW, Romero R, Goodwin TM. PMID: 18059463.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    53. Elective pregnancy termination in a large cohort of women with hyperemesis gravidarum. Contraception. 2007 Dec; 76(6):451-5. Poursharif B, Korst LM, Macgibbon KW, Fejzo MS, Romero R, Goodwin TM. PMID: 18061703.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
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