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Valter D. Longo, PhD

TitleProfessor
InstitutionUniversity of Southern California
DepartmentGerontology
Address3715 McClintock Avenue, GER 319
University Park Campus
Los Angeles CA 90089-0191
Phone+1 213 740 6212
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    Collapse Overview 
    Collapse Overview
    Dr. Longo is the Edna Jones Professor in Gerontology and Professor in Biological Science. He is also the Director of the USC Longevity Institute. He is interested in understanding the fundamental mechanisms of aging in yeast, mice and humans by using genetics and biochemistry techniques. He is also interested in identifying the molecular pathways conserved from simple organisms to humans that can be modulated to protect against multiple stresses and treat or prevent cancer , Alzheimer’s Disease and other diseases of aging. The focus is on the signal transudation pathways that regulate resistance to oxidative damage in yeast and mice.


    Collapse Research 
    Collapse Research Activities and Funding
    Dietary Restriction, GH/IGF-1 & Mechanisms of Cellular Protection and Regeneration
    NIH/NIA P01AG055369Feb 15, 2018 - Jan 31, 2023
    Role: Principal Investigator
    "Interventions to Slow Aging in Humans: Are We Ready?"
    NIH/NIA R13AG046104Sep 1, 2013 - Aug 31, 2014
    Role: Principal Investigator
    Dietary Restriction, GH/IGF-I &Mechanisms of Differential Cellular Protection
    NIH/NIA P01AG034906Dec 1, 2009 - Jul 31, 2017
    Role: Principal Investigator
    Chronological Age-Dependent Genomic Instability in Yeast
    NIH/NIA R01AG025135Jul 1, 2006 - Jun 30, 2011
    Role: Principal Investigator
    Role of Longevity Regulatory Pathways in Age-dependent Macro-molecular Damage in
    NIH/NIA R01AG020642Apr 1, 2002 - May 31, 2018
    Role: Principal Investigator
    4 iron-4sulfur Clusters in Aging and Alzheimer's Disease
    NIH/NIA K01AG001028Sep 30, 2001 - Aug 31, 2005
    Role: Principal Investigator

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    Collapse In The News
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Guidi N, Longo V. Periodic fasting starves cisplatin-resistant cancers to death. EMBO J. 2018 Jun 06. PMID: 29875131.
      View in: PubMed
    2. Buono R, Longo V. Starvation, Stress Resistance, and Cancer. Trends Endocrinol Metab. 2018 Feb 17. PMID: 29463451.
      View in: PubMed
    3. Longo V. Interview with Professor Valter Longo. FEMS Yeast Res. 2017 Nov 23. PMID: 29186374.
      View in: PubMed
    4. Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, Fisher FM, Pissios P, Withers DJ, Selman C, Wang R, Yen K, Longo V, Cohen P, Bartke A, Kopchick JJ, Miller R, Hollenberg AN, Mitchell JR. Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production. Cell Metab. 2017 Jun 06; 25(6):1320-1333.e5. PMID: 28591635.
      View in: PubMed
    5. Di Biase S, Shim HS, Kim KH, Vinciguerra M, Rappa F, Wei M, Brandhorst S, Cappello F, Mirzaei H, Lee C, Longo V. Correction: Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy. PLoS Biol. 2017 May; 15(5):e1002603. PMID: 28459830.
      View in: PubMed
    6. Di Biase S, Shim HS, Kim KH, Vinciguerra M, Rappa F, Wei M, Brandhorst S, Cappello F, Mirzaei H, Lee C, Longo V. Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy. PLoS Biol. 2017 Mar; 15(3):e2001951. PMID: 28358805.
      View in: PubMed
    7. Cheng CW, Villani V, Buono R, Wei M, Kumar S, Yilmaz OH, Cohen P, Sneddon JB, Perin L, Longo V. Fasting-Mimicking Diet Promotes Ngn3-Driven ß-Cell Regeneration to Reverse Diabetes. Cell. 2017 Feb 23; 168(5):775-788.e12. PMID: 28235195.
      View in: PubMed
    8. Brandhorst S, Harputlugil E, Mitchell JR, Longo V. Protective effects of short-term dietary restriction in surgical stress and chemotherapy. Ageing Res Rev. 2017 Oct; 39:68-77. PMID: 28216454.
      View in: PubMed
    9. Wei M, Brandhorst S, Shelehchi M, Mirzaei H, Cheng CW, Budniak J, Groshen S, Mack WJ, Guen E, Di Biase S, Cohen P, Morgan TE, Dorff T, Hong K, Michalsen A, Laviano A, Longo V. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Sci Transl Med. 2017 02 15; 9(377). PMID: 28202779.
      View in: PubMed
    10. Lee AS, Brandhorst S, Rangel DF, Navarrete G, Cohen P, Longo V, Chen J, Groshen S, Morgan TE, Dubeau L. Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice. Sci Rep. 2017 Feb 01; 7:40919. PMID: 28145503.
      View in: PubMed
    11. Choi IY, Lee C, Longo V. Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence. Mol Cell Endocrinol. 2017 Nov 05; 455:4-12. PMID: 28137612.
      View in: PubMed
    12. Nashiro K, Guevara-Aguirre J, Braskie MN, Hafzalla GW, Velasco R, Balasubramanian P, Wei M, Thompson PM, Mather M, Nelson MD, Guevara A, Teran E, Longo V. Brain Structure and Function Associated with Younger Adults in Growth Hormone Receptor-Deficient Humans. J Neurosci. 2017 Feb 15; 37(7):1696-1707. PMID: 28073935.
      View in: PubMed
    13. Longo V, Cortellino S. Enhancing Stem Cell Transplantation with "Nutri-technology". Cell Stem Cell. 2016 12 01; 19(6):681-682. PMID: 27912088.
      View in: PubMed
    14. Vernieri C, Casola S, Foiani M, Pietrantonio F, de Braud F, Longo V. Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions. Cancer Discov. 2016 12; 6(12):1315-1333. PMID: 27872127.
      View in: PubMed
    15. Mattson MP, Longo V, Harvie M. Impact of intermittent fasting on health and disease processes. Ageing Res Rev. 2017 Oct; 39:46-58. PMID: 27810402.
      View in: PubMed
    16. Song M, Fung TT, Hu FB, Willett WC, Longo V, Chan AT, Giovannucci EL. Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality. JAMA Intern Med. 2016 Oct 01; 176(10):1453-1463. PMID: 27479196.
      View in: PubMed
    17. Di Biase S, Lee C, Brandhorst S, Manes B, Buono R, Cheng CW, Cacciottolo M, Martin-Montalvo A, de Cabo R, Wei M, Morgan TE, Longo V. Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity. Cancer Cell. 2016 07 11; 30(1):136-146. PMID: 27411588.
      View in: PubMed
    18. Longo V, Panda S. Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan. Cell Metab. 2016 Jun 14; 23(6):1048-1059. PMID: 27304506.
      View in: PubMed
    19. Dorff TB, Groshen S, Garcia A, Shah M, Tsao-Wei D, Pham H, Cheng CW, Brandhorst S, Cohen P, Wei M, Longo V, Quinn DI. Safety and feasibility of fasting in combination with platinum-based chemotherapy. BMC Cancer. 2016 06 10; 16:360. PMID: 27282289; PMCID: PMC4901417.
      View in: PubMed, PubMed Central
    20. Choi IY, Piccio L, Childress P, Bollman B, Ghosh A, Brandhorst S, Suarez J, Michalsen A, Cross AH, Morgan TE, Wei M, Paul F, Bock M, Longo V. A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms. Cell Rep. 2016 06 07; 15(10):2136-2146. PMID: 27239035; PMCID: PMC4899145.
      View in: PubMed, PubMed Central
    21. Mirzaei H, Di Biase S, Longo V. Dietary Interventions, Cardiovascular Aging, and Disease: Animal Models and Human Studies. Circ Res. 2016 May 13; 118(10):1612-25. PMID: 27174953.
      View in: PubMed
    22. Lee C, Longo V. Dietary restriction with and without caloric restriction for healthy aging. F1000Res. 2016; 5. PMID: 26918181; PMCID: PMC4755412.
      View in: PubMed, PubMed Central
    23. Balasubramanian P, Longo V. Growth factors, aging and age-related diseases. Growth Horm IGF Res. 2016 06; 28:66-8. PMID: 26883276.
      View in: PubMed
    24. Mirzaei H, Raynes R, Longo V. The conserved role of protein restriction in aging and disease. Curr Opin Clin Nutr Metab Care. 2016 Jan; 19(1):74-9. PMID: 26560522; PMCID: PMC4807119 [Available on 01/01/17].
      View in: PubMed, PubMed Central
    25. Brandhorst S, Longo V. Fasting and Caloric Restriction in Cancer Prevention and Treatment. Recent Results Cancer Res. 2016; 207:241-66. PMID: 27557543.
      View in: PubMed
    26. Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin ARMR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker WK, Dhawan P, Diehl AME, Dong JT, Dou QP, Drew JE, Elkord E, El-Rayes B, Feitelson MA, Felsher DW, Ferguson LR, Fimognari C, Firestone GL, Frezza C, Fujii H, Fuster MM, Generali D, Georgakilas AG, Gieseler F, Gilbertson M, Green MF, Grue B, Guha G, Halicka D, Helferich WG, Heneberg P, Hentosh P, Hirschey MD, Hofseth LJ, Holcombe RF, Honoki K, Hsu HY, Huang GS, Jensen LD, Jiang WG, Jones LW, Karpowicz PA, Keith WN, Kerkar SP, Khan GN, Khatami M, Ko YH, Kucuk O, Kulathinal RJ, Kumar NB, Kwon BS, Le A, Lea MA, Lee HY, Lichtor T, Lin LT, Locasale JW, Lokeshwar BL, Longo V, Lyssiotis CA, MacKenzie KL, Malhotra M, Marino M, Martinez-Chantar ML, Matheu A, Maxwell C, McDonnell E, Meeker AK, Mehrmohamadi M, Mehta K, Michelotti GA, Mohammad RM, Mohammed SI, Morre DJ, Muralidhar V, Muqbil I, Murphy MP, Nagaraju GP, Nahta R, Niccolai E, Nowsheen S, Panis C, Pantano F, Parslow VR, Pawelec G, Pedersen PL, Poore B, Poudyal D, Prakash S, Prince M, Raffaghello L, Rathmell JC, Rathmell WK, Ray SK, Reichrath J, Rezazadeh S, Ribatti D, Ricciardiello L, Robey RB, Rodier F, Rupasinghe HPV, Russo GL, Ryan EP, Samadi AK, Sanchez-Garcia I, Sanders AJ, Santini D, Sarkar M, Sasada T, Saxena NK, Shackelford RE, Shantha Kumara HMC, Sharma D, Shin DM, Sidransky D, Siegelin MD, Signori E, Singh N, Sivanand S, Sliva D, Smythe C, Spagnuolo C, Stafforini DM, Stagg J, Subbarayan PR, Sundin T, Talib WH, Thompson SK, Tran PT, Ungefroren H, Vander Heiden MG, Venkateswaran V, Vinay DS, Vlachostergios PJ, Wang Z, Wellen KE, Whelan RL, Yang ES, Yang H, Yang X, Yaswen P, Yedjou C, Yin X, Zhu J, Zollo M. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin Cancer Biol. 2015 Dec; 35 Suppl:S276-S304. PMID: 26590477; PMCID: PMC4819002 [Available on 12/01/16].
      View in: PubMed, PubMed Central
    27. Caffa I, Longo V, Nencioni A. Fasting plus tyrosine kinase inhibitors in cancer. Aging (Albany NY). 2015 Dec; 7(12):1026-7. PMID: 26645151; PMCID: PMC4712327.
      View in: PubMed, PubMed Central
    28. Hirschey MD, DeBerardinis RJ, Diehl AME, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo V, Lyssiotis CA, McDonnell E, Mehrmohamadi M, Michelotti G, Muralidhar V, Murphy MP, Pedersen PL, Poore B, Raffaghello L, Rathmell JC, Sivanand S, Vander Heiden MG, Wellen KE. Dysregulated metabolism contributes to oncogenesis. Semin Cancer Biol. 2015 Dec; 35 Suppl:S129-S150. PMID: 26454069.
      View in: PubMed
    29. Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo V. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab. 2015 Jul 07; 22(1):86-99. PMID: 26094889; PMCID: PMC4509734.
      View in: PubMed, PubMed Central
    30. Bianchi G, Martella R, Ravera S, Marini C, Capitanio S, Orengo A, Emionite L, Lavarello C, Amaro A, Petretto A, Pfeffer U, Sambuceti G, Pistoia V, Raffaghello L, Longo V. Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models. Oncotarget. 2015 May 20; 6(14):11806-19. PMID: 25909219; PMCID: PMC4494906.
      View in: PubMed, PubMed Central
    31. Caffa I, D'Agostino V, Damonte P, Soncini D, Cea M, Monacelli F, Odetti P, Ballestrero A, Provenzani A, Longo V, Nencioni A. Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition. Oncotarget. 2015 May 20; 6(14):11820-32. PMID: 25909220; PMCID: PMC4494907.
      View in: PubMed, PubMed Central
    32. Guevara-Aguirre J, Rosenbloom AL, Balasubramanian P, Teran E, Guevara-Aguirre M, Guevara C, Procel P, Alfaras I, De Cabo R, Di Biase S, Narvaez L, Saavedra J, Longo V. GH Receptor Deficiency in Ecuadorian Adults Is Associated With Obesity and Enhanced Insulin Sensitivity. J Clin Endocrinol Metab. 2015 Jul; 100(7):2589-96. PMID: 25985182; PMCID: PMC4490304.
      View in: PubMed, PubMed Central
    33. Longo V, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell. 2015 Aug; 14(4):497-510. PMID: 25902704.
      View in: PubMed
    34. Shim HS, Wei M, Brandhorst S, Longo V. Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells. Cancer Res. 2015 Mar 15; 75(6):1056-67. PMID: 25614517; PMCID: PMC4359966.
      View in: PubMed, PubMed Central
    35. Shim HS, Longo V. A protein restriction-dependent sulfur code for longevity. Cell. 2015 Jan 15; 160(1-2):15-7. PMID: 25594171.
      View in: PubMed
    36. Mattson MP, Allison DB, Fontana L, Harvie M, Longo V, Malaisse WJ, Mosley M, Notterpek L, Ravussin E, Scheer FA, Seyfried TN, Varady KA, Panda S. Meal frequency and timing in health and disease. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):16647-53. PMID: 25404320; PMCID: PMC4250148.
      View in: PubMed, PubMed Central
    37. Mirzaei H, Suarez JA, Longo V. Protein and amino acid restriction, aging and disease: from yeast to humans. Trends Endocrinol Metab. 2014 Nov; 25(11):558-66. PMID: 25153840; PMCID: PMC4254277.
      View in: PubMed, PubMed Central
    38. Fontana L, Kennedy BK, Longo V, Seals D, Melov S. Medical research: treat ageing. Nature. 2014 Jul 24; 511(7510):405-7. PMID: 25056047.
      View in: PubMed
    39. Lee C, Wan J, Miyazaki B, Fang Y, Guevara-Aguirre J, Yen K, Longo V, Bartke A, Cohen P. IGF-I regulates the age-dependent signaling peptide humanin. Aging Cell. 2014 Oct; 13(5):958-61. PMID: 25040290; PMCID: PMC4172517.
      View in: PubMed, PubMed Central
    40. Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS, Da Sacco S, Mirisola M, Quinn DI, Dorff TB, Kopchick JJ, Longo V. Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell. 2014 Jun 05; 14(6):810-23. PMID: 24905167; PMCID: PMC4102383.
      View in: PubMed, PubMed Central
    41. Mirzaei H, Longo V. Acetyl-CoA synthetase is a conserved regulator of autophagy and life span. Cell Metab. 2014 Apr 01; 19(4):555-7. PMID: 24703691; PMCID: PMC4036695.
      View in: PubMed, PubMed Central
    42. Hu J, Wei M, Mirzaei H, Madia F, Mirisola M, Amparo C, Chagoury S, Kennedy B, Longo V. Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity. Aging Cell. 2014 Jun; 13(3):457-67. PMID: 24649827; PMCID: PMC4032597.
      View in: PubMed, PubMed Central
    43. Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo V. Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab. 2014 Mar 04; 19(3):407-17. PMID: 24606898; PMCID: PMC3988204.
      View in: PubMed, PubMed Central
    44. Mirisola MG, Taormina G, Fabrizio P, Wei M, Hu J, Longo V. Serine- and threonine/valine-dependent activation of PDK and Tor orthologs converge on Sch9 to promote aging. PLoS Genet. 2014 Feb; 10(2):e1004113. PMID: 24516402; PMCID: PMC3916422.
      View in: PubMed, PubMed Central
    45. Longo V, Mattson MP. Fasting: molecular mechanisms and clinical applications. Cell Metab. 2014 Feb 04; 19(2):181-92. PMID: 24440038.
      View in: PubMed
    46. Fontana L, Adelaiye RM, Rastelli AL, Miles KM, Ciamporcero E, Longo V, Nguyen H, Vessella R, Pili R. Dietary protein restriction inhibits tumor growth in human xenograft models. Oncotarget. 2013 Dec; 4(12):2451-61. PMID: 24353195; PMCID: PMC3926840.
      View in: PubMed, PubMed Central
    47. Mercken EM, Hu J, Krzysik-Walker S, Wei M, Li Y, McBurney MW, de Cabo R, Longo V. SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice. Aging Cell. 2014 Feb; 13(1):193-6. PMID: 23941528; PMCID: PMC3907112.
      View in: PubMed, PubMed Central
    48. Nencioni A, Cea M, Montecucco F, Longo V, Patrone F, Carella AM, Holyoake TL, Helgason GV. Autophagy in blood cancers: biological role and therapeutic implications. Haematologica. 2013 Sep; 98(9):1335-43. PMID: 24006406; PMCID: PMC3762088.
      View in: PubMed, PubMed Central
    49. Mirisola MG, Longo V. A radical signal activates the epigenetic regulation of longevity. Cell Metab. 2013 Jun 04; 17(6):812-3. PMID: 23747240.
      View in: PubMed
    50. Bartke A, Sun LY, Longo V. Somatotropic signaling: trade-offs between growth, reproductive development, and longevity. Physiol Rev. 2013 Apr; 93(2):571-98. PMID: 23589828; PMCID: PMC3768106.
      View in: PubMed, PubMed Central
    51. Parrella E, Maxim T, Maialetti F, Zhang L, Wan J, Wei M, Cohen P, Fontana L, Longo V. Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging Cell. 2013 Apr; 12(2):257-68. PMID: 23362919; PMCID: PMC3982836.
      View in: PubMed, PubMed Central
    52. Brandhorst S, Wei M, Hwang S, Morgan TE, Longo V. Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression. Exp Gerontol. 2013 Oct; 48(10):1120-8. PMID: 23454633; PMCID: PMC3762887.
      View in: PubMed, PubMed Central
    53. Balasubramanian P, Longo V. Aging, nutrient signaling, hematopoietic senescence, and cancer. Crit Rev Oncog. 2013; 18(6):559-71. PMID: 24579735; PMCID: PMC3959897.
      View in: PubMed, PubMed Central
    54. Gonidakis S, Longo V. Assessing chronological aging in bacteria. Methods Mol Biol. 2013; 965:421-37. PMID: 23296675; PMCID: PMC4077615.
      View in: PubMed, PubMed Central
    55. Hu J, Wei M, Mirisola MG, Longo V. Assessing chronological aging in Saccharomyces cerevisiae. Methods Mol Biol. 2013; 965:463-72. PMID: 23296677; PMCID: PMC4041521.
      View in: PubMed, PubMed Central
    56. Pfaffenbach KT, Pong M, Morgan TE, Wang H, Ott K, Zhou B, Longo V, Lee AS. GRP78/BiP is a novel downstream target of IGF-1 receptor mediated signaling. J Cell Physiol. 2012 Dec; 227(12):3803-11. PMID: 22422508; PMCID: PMC3421054.
      View in: PubMed, PubMed Central
    57. Safdie F, Brandhorst S, Wei M, Wang W, Lee C, Hwang S, Conti PS, Chen TC, Longo V. Fasting enhances the response of glioma to chemo- and radiotherapy. PLoS One. 2012; 7(9):e44603. PMID: 22984531; PMCID: PMC3439413.
      View in: PubMed, PubMed Central
    58. Mirisola MG, Longo V. Acetic acid and acidification accelerate chronological and replicative aging in yeast. Cell Cycle. 2012 Oct 01; 11(19):3532-3. PMID: 22951542; PMCID: PMC3478300.
      View in: PubMed, PubMed Central
    59. Longo V, Shadel GS, Kaeberlein M, Kennedy B. Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab. 2012 Jul 03; 16(1):18-31. PMID: 22768836; PMCID: PMC3392685.
      View in: PubMed, PubMed Central
    60. Fontana L, Vinciguerra M, Longo V. Growth factors, nutrient signaling, and cardiovascular aging. Circ Res. 2012 Apr 13; 110(8):1139-50. PMID: 22499903; PMCID: PMC3376758.
      View in: PubMed, PubMed Central
    61. Lee C, Raffaghello L, Longo V. Starvation, detoxification, and multidrug resistance in cancer therapy. Drug Resist Updat. 2012 Feb-Apr; 15(1-2):114-22. PMID: 22391012; PMCID: PMC3573885.
      View in: PubMed, PubMed Central
    62. Lee C, Raffaghello L, Brandhorst S, Safdie FM, Bianchi G, Martin-Montalvo A, Pistoia V, Wei M, Hwang S, Merlino A, Emionite L, de Cabo R, Longo V. Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci Transl Med. 2012 Mar 07; 4(124):124ra27. PMID: 22323820; PMCID: PMC3608686.
      View in: PubMed, PubMed Central
    63. Longo V, Fabrizio P. Chronological aging in Saccharomyces cerevisiae. Subcell Biochem. 2012; 57:101-21. PMID: 22094419; PMCID: PMC4048025.
      View in: PubMed, PubMed Central
    64. Longo V, Fontana L. Intermittent supplementation with rapamycin as a dietary restriction mimetic. Aging (Albany NY). 2011 Nov; 3(11):1039-40. PMID: 22147496; PMCID: PMC3249447.
      View in: PubMed, PubMed Central
    65. Wei M, Madia F, Longo V. Studying age-dependent genomic instability using the S. cerevisiae chronological lifespan model. J Vis Exp. 2011 Sep 29; (55). PMID: 21989366; PMCID: PMC3230202.
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    66. Mirisola MG, Longo V. Conserved role of Ras-GEFs in promoting aging: from yeast to mice. Aging (Albany NY). 2011 Apr; 3(4):340-3. PMID: 21732566; PMCID: PMC3117446.
      View in: PubMed, PubMed Central
    67. Sehati S, Clement MH, Martins J, Xu L, Longo V, Valentine JS, Gralla EB. Metabolic alterations in yeast lacking copper-zinc superoxide dismutase. Free Radic Biol Med. 2011 Jun 01; 50(11):1591-8. PMID: 21397007; PMCID: PMC3090513.
      View in: PubMed, PubMed Central
    68. Gonidakis S, Finkel SE, Longo V. Lifespan extension and paraquat resistance in a ubiquinone-deficient Escherichia coli mutant depend on transcription factors ArcA and TdcA. Aging (Albany NY). 2011 Mar; 3(3):291-303. PMID: 21464517; PMCID: PMC3091522.
      View in: PubMed, PubMed Central
    69. Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo V. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med. 2011 Feb 16; 3(70):70ra13. PMID: 21325617.
      View in: PubMed
    70. Longo V, Nislow C, Fabrizio P. Endosomal protein sorting and autophagy genes contribute to the regulation of yeast life span. Autophagy. 2010 Nov; 6(8):1227-8. PMID: 20953148.
      View in: PubMed
    71. Raffaghello L, Safdie F, Bianchi G, Dorff T, Fontana L, Longo V. Fasting and differential chemotherapy protection in patients. Cell Cycle. 2010 Nov 15; 9(22):4474-6. PMID: 21088487; PMCID: PMC3048045.
      View in: PubMed, PubMed Central
    72. Gonidakis S, Finkel SE, Longo V. E. coli hypoxia-inducible factor ArcA mediates lifespan extension in a lipoic acid synthase mutant by suppressing acetyl-CoA synthetase. Biol Chem. 2010 Oct; 391(10):1139-47. PMID: 20707605; PMCID: PMC4403634.
      View in: PubMed, PubMed Central
    73. Gonidakis S, Finkel SE, Longo V. Genome-wide screen identifies Escherichia coli TCA-cycle-related mutants with extended chronological lifespan dependent on acetate metabolism and the hypoxia-inducible transcription factor ArcA. Aging Cell. 2010 Oct; 9(5):868-81. PMID: 20707865; PMCID: PMC2941539.
      View in: PubMed, PubMed Central
    74. Balasubramanian P, Longo V. Linking Klotho, Nrf2, MAP kinases and aging. Aging (Albany NY). 2010 Oct; 2(10):632-3. PMID: 21076180; PMCID: PMC2993790.
      View in: PubMed, PubMed Central
    75. Michán S, Li Y, Chou MM, Parrella E, Ge H, Long JM, Allard JS, Lewis K, Miller M, Xu W, Mervis RF, Chen J, Guerin KI, Smith LE, McBurney MW, Sinclair DA, Baudry M, de Cabo R, Longo V. SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci. 2010 Jul 21; 30(29):9695-707. PMID: 20660252; PMCID: PMC2921958.
      View in: PubMed, PubMed Central
    76. Fabrizio P, Hoon S, Shamalnasab M, Galbani A, Wei M, Giaever G, Nislow C, Longo V. Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation. PLoS Genet. 2010 Jul 15; 6(7):e1001024. PMID: 20657825; PMCID: PMC2904796.
      View in: PubMed, PubMed Central
    77. Finch CE, Morgan TE, Longo V, de Magalhaes JP. Cell resilience in species life spans: a link to inflammation? Aging Cell. 2010 Aug; 9(4):519-26. PMID: 20415721; PMCID: PMC2952360.
      View in: PubMed, PubMed Central
    78. Fontana L, Partridge L, Longo V. Extending healthy life span--from yeast to humans. Science. 2010 Apr 16; 328(5976):321-6. PMID: 20395504; PMCID: PMC3607354.
      View in: PubMed, PubMed Central
    79. Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS, Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, Vijg J. Impact papers on aging in 2009. Aging (Albany NY). 2010 Mar; 2(3):111-21. PMID: 20351400; PMCID: PMC2871240.
      View in: PubMed, PubMed Central
    80. Lee C, Safdie FM, Raffaghello L, Wei M, Madia F, Parrella E, Hwang D, Cohen P, Bianchi G, Longo V. Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Res. 2010 Feb 15; 70(4):1564-72. PMID: 20145127; PMCID: PMC2836202.
      View in: PubMed, PubMed Central
    81. Longo V, Fontana L. Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends Pharmacol Sci. 2010 Feb; 31(2):89-98. PMID: 20097433; PMCID: PMC2829867.
      View in: PubMed, PubMed Central
    82. Parrella E, Longo V. Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain. ScientificWorldJournal. 2010 Jan 21; 10:161-77. PMID: 20098959; PMCID: PMC4405166.
      View in: PubMed, PubMed Central
    83. Safdie FM, Dorff T, Quinn D, Fontana L, Wei M, Lee C, Cohen P, Longo V. Fasting and cancer treatment in humans: A case series report. Aging (Albany NY). 2009 Dec 31; 1(12):988-1007. PMID: 20157582; PMCID: PMC2815756.
      View in: PubMed, PubMed Central
    84. Ge H, Wei M, Fabrizio P, Hu J, Cheng C, Longo V, Li LM. Comparative analyses of time-course gene expression profiles of the long-lived sch9Delta mutant. Nucleic Acids Res. 2010 Jan; 38(1):143-58. PMID: 19880387; PMCID: PMC2800218.
      View in: PubMed, PubMed Central
    85. Madia F, Wei M, Yuan V, Hu J, Gattazzo C, Pham P, Goodman MF, Longo V. Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polzeta-dependent mechanism. J Cell Biol. 2009 Aug 24; 186(4):509-23. PMID: 19687253; PMCID: PMC2733759.
      View in: PubMed, PubMed Central
    86. Wei M, Fabrizio P, Madia F, Hu J, Ge H, Li LM, Longo V. Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension. PLoS Genet. 2009 May; 5(5):e1000467. PMID: 19424415; PMCID: PMC2669710.
      View in: PubMed, PubMed Central
    87. Longo V, Lieber MR, Vijg J. Turning anti-ageing genes against cancer. Nat Rev Mol Cell Biol. 2008 11; 9(11):903-10. PMID: 18946478.
      View in: PubMed
    88. Parrella E, Longo V. The chronological life span of Saccharomyces cerevisiae to study mitochondrial dysfunction and disease. Methods. 2008 Dec; 46(4):256-62. PMID: 18930829.
      View in: PubMed
    89. Li Y, Xu W, McBurney MW, Longo V. SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab. 2008 Jul; 8(1):38-48. PMID: 18590691; PMCID: PMC2822839.
      View in: PubMed, PubMed Central
    90. Longo V. Linking sirtuins, IGF-I signaling, and starvation. Exp Gerontol. 2009 Jan-Feb; 44(1-2):70-4. PMID: 18638538.
      View in: PubMed
    91. Fabrizio P, Longo V. Chronological aging-induced apoptosis in yeast. Biochim Biophys Acta. 2008 Jul; 1783(7):1280-5. PMID: 18445486; PMCID: PMC2536486.
      View in: PubMed, PubMed Central
    92. Raffaghello L, Lee C, Safdie FM, Wei M, Madia F, Bianchi G, Longo V. Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proc Natl Acad Sci U S A. 2008 Jun 17; 105(24):8215-20. PMID: 18378900; PMCID: PMC2448817.
      View in: PubMed, PubMed Central
    93. Madia F, Gattazzo C, Wei M, Fabrizio P, Burhans WC, Weinberger M, Galbani A, Smith JR, Nguyen C, Huey S, Comai L, Longo V. Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system. J Cell Biol. 2008 Jan 14; 180(1):67-81. PMID: 18195102; PMCID: PMC2213615.
      View in: PubMed, PubMed Central
    94. Wei M, Fabrizio P, Hu J, Ge H, Cheng C, Li L, Longo V. Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. PLoS Genet. 2008 Jan; 4(1):e13. PMID: 18225956; PMCID: PMC2213705.
      View in: PubMed, PubMed Central
    95. Cheng C, Fabrizio P, Ge H, Wei M, Longo V, Li LM. Significant and systematic expression differentiation in long-lived yeast strains. PLoS One. 2007 Oct 31; 2(10):e1095. PMID: 17971858; PMCID: PMC2039703.
      View in: PubMed, PubMed Central
    96. Cheng C, Fabrizio P, Ge H, Longo V, Li LM. Inference of transcription modification in long-live yeast strains from their expression profiles. BMC Genomics. 2007 Jul 06; 8:219. PMID: 17617911; PMCID: PMC1949827.
      View in: PubMed, PubMed Central
    97. Fabrizio P, Longo V. The chronological life span of Saccharomyces cerevisiae. Methods Mol Biol. 2007; 371:89-95. PMID: 17634576.
      View in: PubMed
    98. Longo V, Kennedy BK. Sirtuins in aging and age-related disease. Cell. 2006 Jul 28; 126(2):257-68. PMID: 16873059.
      View in: PubMed
    99. Skulachev VP, Longo V. Aging as a mitochondria-mediated atavistic program: can aging be switched off? Ann N Y Acad Sci. 2005 Dec; 1057:145-64. PMID: 16399892.
      View in: PubMed
    100. Fabrizio P, Gattazzo C, Battistella L, Wei M, Cheng C, McGrew K, Longo V. Sir2 blocks extreme life-span extension. Cell. 2005 Nov 18; 123(4):655-67. PMID: 16286010.
      View in: PubMed
    101. Longo V, Mitteldorf J, Skulachev VP. Programmed and altruistic ageing. Nat Rev Genet. 2005 Nov; 6(11):866-72. PMID: 16304601.
      View in: PubMed
    102. Fabrizio P, Li L, Longo V. Analysis of gene expression profile in yeast aging chronologically. Mech Ageing Dev. 2005 Jan; 126(1):11-6. PMID: 15610757.
      View in: PubMed
    103. Longo V. Ras: the other pro-aging pathway. Sci Aging Knowledge Environ. 2004 Sep 29; 2004(39):pe36. PMID: 15456908.
      View in: PubMed
    104. Fabrizio P, Battistella L, Vardavas R, Gattazzo C, Liou LL, Diaspro A, Dossen JW, Gralla EB, Longo V. Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae. J Cell Biol. 2004 Sep 27; 166(7):1055-67. PMID: 15452146; PMCID: PMC2172019.
      View in: PubMed, PubMed Central
    105. Wallace MA, Liou LL, Martins J, Clement MH, Bailey S, Longo V, Valentine JS, Gralla EB. Superoxide inhibits 4Fe-4S cluster enzymes involved in amino acid biosynthesis. Cross-compartment protection by CuZn-superoxide dismutase. J Biol Chem. 2004 Jul 30; 279(31):32055-62. PMID: 15166213.
      View in: PubMed
    106. Longo V. Search for methuselah genes heats up. Sci Aging Knowledge Environ. 2004 Feb 11; 2004(6):pe6. PMID: 14960761.
      View in: PubMed
    107. Gendron CM, Minois N, Fabrizio P, Longo V, Pletcher SD, Vaupel JW. Biodemographic trajectories of age-specific reproliferation from stationary phase in the yeast Saccharomyces cerevisiae seem multiphasic. Mech Ageing Dev. 2003 Dec; 124(10-12):1059-63. PMID: 14659594.
      View in: PubMed
    108. Longo V. The Ras and Sch9 pathways regulate stress resistance and longevity. Exp Gerontol. 2003 Jul; 38(7):807-11. PMID: 12855292.
      View in: PubMed
    109. Fabrizio P, Longo V. The chronological life span of Saccharomyces cerevisiae. Aging Cell. 2003 Apr; 2(2):73-81. PMID: 12882320.
      View in: PubMed
    110. Longo V, Finch CE. Evolutionary medicine: from dwarf model systems to healthy centenarians? Science. 2003 Feb 28; 299(5611):1342-6. PMID: 12610293.
      View in: PubMed
    111. Fabrizio P, Liou LL, Moy VN, Diaspro A, Valentine JS, Gralla EB, Longo V. SOD2 functions downstream of Sch9 to extend longevity in yeast. Genetics. 2003 Jan; 163(1):35-46. PMID: 12586694; PMCID: PMC1462415.
      View in: PubMed, PubMed Central
    112. Longo V, Finch CE. Genetics of aging and diseases: from rare mutations and model systems to disease prevention. Arch Neurol. 2002 Nov; 59(11):1706-8. PMID: 12433254.
      View in: PubMed
    113. Longo V. Oxygen? No thanks, I'm on a diet. Sci Aging Knowledge Environ. 2002 Jun 19; 2002(24):pe10. PMID: 14602992.
      View in: PubMed
    114. Longo V, Fabrizio P. Regulation of longevity and stress resistance: a molecular strategy conserved from yeast to humans? Cell Mol Life Sci. 2002 Jun; 59(6):903-8. PMID: 12169020.
      View in: PubMed
    115. Xie Z, Wei M, Morgan TE, Fabrizio P, Han D, Finch CE, Longo V. Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia. J Neurosci. 2002 May 01; 22(9):3484-92. PMID: 11978825.
      View in: PubMed
    116. Longo V, Viola KL, Klein WL, Finch CE. Reversible inactivation of superoxide-sensitive aconitase in Abeta1-42-treated neuronal cell lines. J Neurochem. 2000 Nov; 75(5):1977-85. PMID: 11032887.
      View in: PubMed
    117. Longo V. Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells. Neurobiol Aging. 1999 Sep-Oct; 20(5):479-86. PMID: 10638521.
      View in: PubMed
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