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Valter D. Longo, PhD

Title(s)Professor
Address3715 McClintock Avenue, GER 319
University Park Campus
Los Angeles CA 90089-0191
Phone+1 213 740 6212
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    Dr. Longo is the Edna Jones Professor in Gerontology and Professor in Biological Science. He is also the Director of the USC Longevity Institute. He is interested in understanding the fundamental mechanisms of aging in yeast, mice and humans by using genetics and biochemistry techniques. He is also interested in identifying the molecular pathways conserved from simple organisms to humans that can be modulated to protect against multiple stresses and treat or prevent cancer , Alzheimer’s Disease and other diseases of aging. The focus is on the signal transudation pathways that regulate resistance to oxidative damage in yeast and mice.

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    Dietary Restriction, GH/IGF-1 & Mechanisms of Cellular Protection and Regeneration
    NIH/NIA P01AG055369Feb 15, 2018 - Jan 31, 2023
    Role: Principal Investigator
    "Interventions to Slow Aging in Humans: Are We Ready?"
    NIH/NIA R13AG046104Sep 1, 2013 - Aug 31, 2014
    Role: Principal Investigator
    Dietary Restriction, GH/IGF-I &Mechanisms of Differential Cellular Protection
    NIH/NIA P01AG034906Dec 1, 2009 - Jul 31, 2017
    Role: Principal Investigator
    Chronological Age-Dependent Genomic Instability in Yeast
    NIH/NIA R01AG025135Jul 1, 2006 - Jun 30, 2011
    Role: Principal Investigator
    Role of Longevity Regulatory Pathways in Age-dependent Macro-molecular Damage in
    NIH/NIA R01AG020642Apr 1, 2002 - May 31, 2018
    Role: Principal Investigator
    4 iron-4sulfur Clusters in Aging and Alzheimer's Disease
    NIH/NIA K01AG001028Sep 30, 2001 - Aug 31, 2005
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Fasting, Dietary Restriction, and Immunosenescence. J Allergy Clin Immunol. 2020 Aug 24. Longo VD, Cortellino S. PMID: 32853639.
      View in: PubMed   Mentions:    Fields:    
    2. Fasting-mimicking diet and hormone therapy induce breast cancer regression. Nature. 2020 Jul; 583(7817):620-624. Caffa I, Spagnolo V, Vernieri C, Valdemarin F, Becherini P, Wei M, Brandhorst S, Zucal C, Driehuis E, Ferrando L, Piacente F, Tagliafico A, Cilli M, Mastracci L, Vellone VG, Piazza S, Cremonini AL, Gradaschi R, Mantero C, Passalacqua M, Ballestrero A, Zoppoli G, Cea M, Arrighi A, Odetti P, Monacelli F, Salvadori G, Cortellino S, Clevers H, De Braud F, Sukkar SG, Provenzani A, Longo VD, Nencioni A. PMID: 32669709.
      View in: PubMed   Mentions: 2     Fields:    
    3. Fasting in diabetes treatment (FIT) trial: study protocol for a randomised, controlled, assessor-blinded intervention trial on the effects of intermittent use of a fasting-mimicking diet in patients with type 2 diabetes. BMC Endocr Disord. 2020 Jun 24; 20(1):94. van den Burg EL, Schoonakker MP, van Peet PG, van den Akker-van Marle ME, Willems van Dijk K, Longo VD, Lamb HJ, Numans ME, Pijl H. PMID: 32580710.
      View in: PubMed   Mentions:    Fields:    
    4. The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan. Aging (Albany NY). 2020 Jun 23; 12(12):11185-11199. Yen K, Mehta HH, Kim SJ, Lue Y, Hoang J, Guerrero N, Port J, Bi Q, Navarrete G, Brandhorst S, Lewis KN, Wan J, Swerdloff R, Mattison JA, Buffenstein R, Breton CV, Wang C, Longo V, Atzmon G, Wallace D, Barzilai N, Cohen P. PMID: 32575074.
      View in: PubMed   Mentions:    Fields:    
    5. Fasting mimicking diet as an adjunct to?neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial. Nat Commun. 2020 06 23; 11(1):3083. de Groot S, Lugtenberg RT, Cohen D, Welters MJP, Ehsan I, Vreeswijk MPG, Smit VTHBM, de Graaf H, Heijns JB, Portielje JEA, van de Wouw AJ, Imholz ALT, Kessels LW, Vrijaldenhoven S, Baars A, Kranenbarg EM, Carpentier MD, Putter H, van der Hoeven JJM, Nortier JWR, Longo VD, Pijl H, Kroep JR. PMID: 32576828.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    6. Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers. Nat Commun. 2020 05 11; 11(1):2332. Di Tano M, Raucci F, Vernieri C, Caffa I, Buono R, Fanti M, Brandhorst S, Curigliano G, Nencioni A, de Braud F, Longo VD. PMID: 32393788.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. Efficacy of a fasting-mimicking diet in functional therapy for depression: A randomised controlled pilot trial. J Clin Psychol. 2020 May 11. Maniaci G, La Cascia C, Giammanco A, Ferraro L, Chianetta R, Di Peri R, Sardella Z, Citarrella R, Mannella Y, Larcan S, Montana S, Mirisola MG, Longo V, Rizzo M, La Barbera D. PMID: 32394438.
      View in: PubMed   Mentions:    Fields:    
    8. Strategies to Prevent or Remediate Cancer and Treatment-Related Aging. J Natl Cancer Inst. 2020 Apr 29. Guida JL, Agurs-Collins T, Ahles TA, Campisi J, Dale W, Demark-Wahnefried W, Dietrich J, Fuldner R, Gallicchio L, Green PA, Hurria A, Janelsins MC, Jhappan C, Kirkland JL, Kohanski R, Longo V, Meydani S, Mohile S, Niedernhofer LJ, Nelson C, Perna F, Schadler K, Scott JM, Schrack JA, Tracy RP, van Deursen J, Ness KK. PMID: 32348501.
      View in: PubMed   Mentions:    Fields:    
    9. Growth hormone receptor deficiency in humans associates to obesity, increased body fat percentage, a healthy brain and a coordinated insulin sensitivity. Growth Horm IGF Res. 2020 04; 51:58-64. Guevara-Aguirre J, Teran E, Lescano D, Guevara A, Guevara C, Longo V, Gavilanes AWD. PMID: 32145513.
      View in: PubMed   Mentions:    Fields:    
    10. Protein Quantity and Source, Fasting-Mimicking Diets, and Longevity. Adv Nutr. 2019 11 01; 10(Suppl_4):S340-S350. Brandhorst S, Longo VD. PMID: 31728501.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    11. When Fasting Gets Tough, the Tough Immune Cells Get Going-or Die. Cell. 2019 08 22; 178(5):1038-1040. Buono R, Longo VD. PMID: 31442398.
      View in: PubMed   Mentions: 1     Fields:    
    12. Dietary Restrictions and Nutrition in the Prevention and Treatment of Cardiovascular Disease. Circ Res. 2019 03 15; 124(6):952-965. Brandhorst S, Longo VD. PMID: 30870119.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    13. Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology. Cell Rep. 2019 03 05; 26(10):2704-2719.e6. Rangan P, Choi I, Wei M, Navarrete G, Guen E, Brandhorst S, Enyati N, Pasia G, Maesincee D, Ocon V, Abdulridha M, Longo VD. PMID: 30840892.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    14. Reply to 'Fasting in oncology: a word of caution'. Nat Rev Cancer. 2019 03; 19(3):178. Nencioni A, Caffa I, Cortellino S, Longo VD. PMID: 30651605.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Fasting and cancer: molecular mechanisms and clinical application. Nat Rev Cancer. 2018 11; 18(11):707-719. Nencioni A, Caffa I, Cortellino S, Longo VD. PMID: 30327499.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    16. Programmed longevity, youthspan, and juventology. Aging Cell. 2019 02; 18(1):e12843. Longo VD. PMID: 30334314.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    17. Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans. Sci Rep. 2018 09 21; 8(1):14212. Yen K, Wan J, Mehta HH, Miller B, Christensen A, Levine ME, Salomon MP, Brandhorst S, Xiao J, Kim SJ, Navarrete G, Campo D, Harry GJ, Longo V, Pike CJ, Mack WJ, Hodis HN, Crimmins EM, Cohen P. PMID: 30242290.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    18. Periodic fasting starves cisplatin-resistant cancers to death. EMBO J. 2018 07 13; 37(14). Guidi N, Longo VD. PMID: 29875131.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. Starvation, Stress Resistance, and Cancer. Trends Endocrinol Metab. 2018 04; 29(4):271-280. Buono R, Longo VD. PMID: 29463451.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    20. Interview with Professor Valter Longo. FEMS Yeast Res. 2017 Nov 23. Longo V. PMID: 29186374.
      View in: PubMed   Mentions:    Fields:    
    21. Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production. Cell Metab. 2017 Jun 06; 25(6):1320-1333.e5. Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, Fisher FM, Pissios P, Withers DJ, Selman C, Wang R, Yen K, Longo VD, Cohen P, Bartke A, Kopchick JJ, Miller R, Hollenberg AN, Mitchell JR. PMID: 28591635.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    22. Correction: Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy. PLoS Biol. 2017 May; 15(5):e1002603. Di Biase S, Shim HS, Kim KH, Vinciguerra M, Rappa F, Wei M, Brandhorst S, Cappello F, Mirzaei H, Lee C, Longo VD. PMID: 28459830.
      View in: PubMed   Mentions: 2     Fields:    
    23. Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy. PLoS Biol. 2017 03; 15(3):e2001951. Di Biase S, Shim HS, Kim KH, Vinciguerra M, Rappa F, Wei M, Brandhorst S, Cappello F, Mirzaei H, Lee C, Longo VD. PMID: 28358805.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    24. Metabolic Alterations at the Crossroad of Aging and Oncogenesis. Int Rev Cell Mol Biol. 2017; 332:1-42. Raffaghello L, Longo V. PMID: 28526131.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    25. Fasting-Mimicking Diet Promotes Ngn3-Driven ß-Cell Regeneration to Reverse Diabetes. Cell. 2017 02 23; 168(5):775-788.e12. Cheng CW, Villani V, Buono R, Wei M, Kumar S, Yilmaz OH, Cohen P, Sneddon JB, Perin L, Longo VD. PMID: 28235195.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    26. Protective effects of short-term dietary restriction in surgical stress and chemotherapy. Ageing Res Rev. 2017 Oct; 39:68-77. Brandhorst S, Harputlugil E, Mitchell JR, Longo VD. PMID: 28216454.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    27. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Sci Transl Med. 2017 02 15; 9(377). Wei M, Brandhorst S, Shelehchi M, Mirzaei H, Cheng CW, Budniak J, Groshen S, Mack WJ, Guen E, Di Biase S, Cohen P, Morgan TE, Dorff T, Hong K, Michalsen A, Laviano A, Longo VD. PMID: 28202779.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    28. Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice. Sci Rep. 2017 02 01; 7:40919. Lee AS, Brandhorst S, Rangel DF, Navarrete G, Cohen P, Longo VD, Chen J, Groshen S, Morgan TE, Dubeau L. PMID: 28145503.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    29. Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence. Mol Cell Endocrinol. 2017 Nov 05; 455:4-12. Choi IY, Lee C, Longo VD. PMID: 28137612.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    30. Brain Structure and Function Associated with Younger Adults in Growth Hormone Receptor-Deficient Humans. J Neurosci. 2017 02 15; 37(7):1696-1707. Nashiro K, Guevara-Aguirre J, Braskie MN, Hafzalla GW, Velasco R, Balasubramanian P, Wei M, Thompson PM, Mather M, Nelson MD, Guevara A, Teran E, Longo VD. PMID: 28073935.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    31. Enhancing Stem Cell Transplantation with "Nutri-technology". Cell Stem Cell. 2016 12 01; 19(6):681-682. Longo VD, Cortellino S. PMID: 27912088.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    32. Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions. Cancer Discov. 2016 12; 6(12):1315-1333. Vernieri C, Casola S, Foiani M, Pietrantonio F, de Braud F, Longo V. PMID: 27872127.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    33. Impact of intermittent fasting on health and disease processes. Ageing Res Rev. 2017 Oct; 39:46-58. Mattson MP, Longo VD, Harvie M. PMID: 27810402.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimals
    34. Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality. JAMA Intern Med. 2016 Oct 01; 176(10):1453-1463. Song M, Fung TT, Hu FB, Willett WC, Longo VD, Chan AT, Giovannucci EL. PMID: 27479196.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimals
    35. Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity. Cancer Cell. 2016 07 11; 30(1):136-146. Di Biase S, Lee C, Brandhorst S, Manes B, Buono R, Cheng CW, Cacciottolo M, Martin-Montalvo A, de Cabo R, Wei M, Morgan TE, Longo VD. PMID: 27411588.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    36. Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan. Cell Metab. 2016 06 14; 23(6):1048-1059. Longo VD, Panda S. PMID: 27304506.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimals
    37. Safety and feasibility of fasting in combination with platinum-based chemotherapy. BMC Cancer. 2016 06 10; 16:360. Dorff TB, Groshen S, Garcia A, Shah M, Tsao-Wei D, Pham H, Cheng CW, Brandhorst S, Cohen P, Wei M, Longo V, Quinn DI. PMID: 27282289.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    38. A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms. Cell Rep. 2016 06 07; 15(10):2136-2146. Choi IY, Piccio L, Childress P, Bollman B, Ghosh A, Brandhorst S, Suarez J, Michalsen A, Cross AH, Morgan TE, Wei M, Paul F, Bock M, Longo VD. PMID: 27239035.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    39. Dietary Interventions, Cardiovascular Aging, and Disease: Animal Models and Human Studies. Circ Res. 2016 05 13; 118(10):1612-25. Mirzaei H, Di Biase S, Longo VD. PMID: 27174953.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    40. Dietary restriction with and without caloric restriction for healthy aging. F1000Res. 2016; 5. Lee C, Longo V. PMID: 26918181.
      View in: PubMed   Mentions: 25     Fields:    
    41. Growth factors, aging and age-related diseases. Growth Horm IGF Res. 2016 06; 28:66-8. Balasubramanian P, Longo VD. PMID: 26883276.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    42. The conserved role of protein restriction in aging and disease. Curr Opin Clin Nutr Metab Care. 2016 Jan; 19(1):74-9. Mirzaei H, Raynes R, Longo VD. PMID: 26560522.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    43. Fasting and Caloric Restriction in Cancer Prevention and Treatment. Recent Results Cancer Res. 2016; 207:241-66. Brandhorst S, Longo VD. PMID: 27557543.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    44. Fasting-induced differential stress sensitization in cancer treatment. Mol Cell Oncol. 2016 May; 3(3):e1117701. Di Biase S, Longo VD. PMID: 27314084.
      View in: PubMed   Mentions:
    45. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin Cancer Biol. 2015 Dec; 35 Suppl:S276-S304. Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin ARMR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker WK, Dhawan P, Diehl AME, Dong JT, Dou QP, Drew JE, Elkord E, El-Rayes B, Feitelson MA, Felsher DW, Ferguson LR, Fimognari C, Firestone GL, Frezza C, Fujii H, Fuster MM, Generali D, Georgakilas AG, Gieseler F, Gilbertson M, Green MF, Grue B, Guha G, Halicka D, Helferich WG, Heneberg P, Hentosh P, Hirschey MD, Hofseth LJ, Holcombe RF, Honoki K, Hsu HY, Huang GS, Jensen LD, Jiang WG, Jones LW, Karpowicz PA, Keith WN, Kerkar SP, Khan GN, Khatami M, Ko YH, Kucuk O, Kulathinal RJ, Kumar NB, Kwon BS, Le A, Lea MA, Lee HY, Lichtor T, Lin LT, Locasale JW, Lokeshwar BL, Longo VD, Lyssiotis CA, MacKenzie KL, Malhotra M, Marino M, Martinez-Chantar ML, Matheu A, Maxwell C, McDonnell E, Meeker AK, Mehrmohamadi M, Mehta K, Michelotti GA, Mohammad RM, Mohammed SI, Morre DJ, Muralidhar V, Muqbil I, Murphy MP, Nagaraju GP, Nahta R, Niccolai E, Nowsheen S, Panis C, Pantano F, Parslow VR, Pawelec G, Pedersen PL, Poore B, Poudyal D, Prakash S, Prince M, Raffaghello L, Rathmell JC, Rathmell WK, Ray SK, Reichrath J, Rezazadeh S, Ribatti D, Ricciardiello L, Robey RB, Rodier F, Rupasinghe HPV, Russo GL, Ryan EP, Samadi AK, Sanchez-Garcia I, Sanders AJ, Santini D, Sarkar M, Sasada T, Saxena NK, Shackelford RE, Shantha Kumara HMC, Sharma D, Shin DM, Sidransky D, Siegelin MD, Signori E, Singh N, Sivanand S, Sliva D, Smythe C, Spagnuolo C, Stafforini DM, Stagg J, Subbarayan PR, Sundin T, Talib WH, Thompson SK, Tran PT, Ungefroren H, Vander Heiden MG, Venkateswaran V, Vinay DS, Vlachostergios PJ, Wang Z, Wellen KE, Whelan RL, Yang ES, Yang H, Yang X, Yaswen P, Yedjou C, Yin X, Zhu J, Zollo M. PMID: 26590477.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    46. Fasting plus tyrosine kinase inhibitors in cancer. Aging (Albany NY). 2015 Dec; 7(12):1026-7. Caffa I, Longo VD, Nencioni A. PMID: 26645151.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    47. Dysregulated metabolism contributes to oncogenesis. Semin Cancer Biol. 2015 Dec; 35 Suppl:S129-S150. Hirschey MD, DeBerardinis RJ, Diehl AME, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell E, Mehrmohamadi M, Michelotti G, Muralidhar V, Murphy MP, Pedersen PL, Poore B, Raffaghello L, Rathmell JC, Sivanand S, Vander Heiden MG, Wellen KE. PMID: 26454069.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    48. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab. 2015 Jul 07; 22(1):86-99. Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD. PMID: 26094889.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimals
    49. Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models. Oncotarget. 2015 May 20; 6(14):11806-19. Bianchi G, Martella R, Ravera S, Marini C, Capitanio S, Orengo A, Emionite L, Lavarello C, Amaro A, Petretto A, Pfeffer U, Sambuceti G, Pistoia V, Raffaghello L, Longo VD. PMID: 25909219.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    50. Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition. Oncotarget. 2015 May 20; 6(14):11820-32. Caffa I, D'Agostino V, Damonte P, Soncini D, Cea M, Monacelli F, Odetti P, Ballestrero A, Provenzani A, Longo VD, Nencioni A. PMID: 25909220.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    51. GH Receptor Deficiency in Ecuadorian Adults Is Associated With Obesity and Enhanced Insulin Sensitivity. J Clin Endocrinol Metab. 2015 Jul; 100(7):2589-96. Guevara-Aguirre J, Rosenbloom AL, Balasubramanian P, Teran E, Guevara-Aguirre M, Guevara C, Procel P, Alfaras I, De Cabo R, Di Biase S, Narvaez L, Saavedra J, Longo VD. PMID: 25985182.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    52. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell. 2015 Aug; 14(4):497-510. Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L. PMID: 25902704.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    53. Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells. Cancer Res. 2015 Mar 15; 75(6):1056-67. Shim HS, Wei M, Brandhorst S, Longo VD. PMID: 25614517.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    54. A protein restriction-dependent sulfur code for longevity. Cell. 2015 Jan 15; 160(1-2):15-7. Shim HS, Longo VD. PMID: 25594171.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    55. Meal frequency and timing in health and disease. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):16647-53. Mattson MP, Allison DB, Fontana L, Harvie M, Longo VD, Malaisse WJ, Mosley M, Notterpek L, Ravussin E, Scheer FA, Seyfried TN, Varady KA, Panda S. PMID: 25404320.
      View in: PubMed   Mentions: 85     Fields:    Translation:Humans
    56. Protein and amino acid restriction, aging and disease: from yeast to humans. Trends Endocrinol Metab. 2014 Nov; 25(11):558-66. Mirzaei H, Suarez JA, Longo VD. PMID: 25153840.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    57. Medical research: treat ageing. Nature. 2014 Jul 24; 511(7510):405-7. Fontana L, Kennedy BK, Longo VD, Seals D, Melov S. PMID: 25056047.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimals
    58. IGF-I regulates the age-dependent signaling peptide humanin. Aging Cell. 2014 Oct; 13(5):958-61. Lee C, Wan J, Miyazaki B, Fang Y, Guevara-Aguirre J, Yen K, Longo V, Bartke A, Cohen P. PMID: 25040290.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    59. Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell. 2014 Jun 05; 14(6):810-23. Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS, Da Sacco S, Mirisola M, Quinn DI, Dorff TB, Kopchick JJ, Longo VD. PMID: 24905167.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    60. Acetyl-CoA synthetase is a conserved regulator of autophagy and life span. Cell Metab. 2014 Apr 01; 19(4):555-7. Mirzaei H, Longo VD. PMID: 24703691.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    61. Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity. Aging Cell. 2014 Jun; 13(3):457-67. Hu J, Wei M, Mirzaei H, Madia F, Mirisola M, Amparo C, Chagoury S, Kennedy B, Longo VD. PMID: 24649827.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    62. Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab. 2014 Mar 04; 19(3):407-17. Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo VD. PMID: 24606898.
      View in: PubMed   Mentions: 162     Fields:    Translation:HumansAnimalsCells
    63. Serine- and threonine/valine-dependent activation of PDK and Tor orthologs converge on Sch9 to promote aging. PLoS Genet. 2014 Feb; 10(2):e1004113. Mirisola MG, Taormina G, Fabrizio P, Wei M, Hu J, Longo VD. PMID: 24516402.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    64. Fasting: molecular mechanisms and clinical applications. Cell Metab. 2014 Feb 04; 19(2):181-92. Longo VD, Mattson MP. PMID: 24440038.
      View in: PubMed   Mentions: 192     Fields:    Translation:HumansAnimals
    65. Dietary protein restriction inhibits tumor growth in human xenograft models. Oncotarget. 2013 Dec; 4(12):2451-61. Fontana L, Adelaiye RM, Rastelli AL, Miles KM, Ciamporcero E, Longo VD, Nguyen H, Vessella R, Pili R. PMID: 24353195.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    66. SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice. Aging Cell. 2014 Feb; 13(1):193-6. Mercken EM, Hu J, Krzysik-Walker S, Wei M, Li Y, McBurney MW, de Cabo R, Longo VD. PMID: 23941528.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    67. Autophagy in blood cancers: biological role and therapeutic implications. Haematologica. 2013 Sep; 98(9):1335-43. Nencioni A, Cea M, Montecucco F, Longo VD, Patrone F, Carella AM, Holyoake TL, Helgason GV. PMID: 24006406.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    68. A radical signal activates the epigenetic regulation of longevity. Cell Metab. 2013 Jun 04; 17(6):812-3. Mirisola MG, Longo VD. PMID: 23747240.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    69. Somatotropic signaling: trade-offs between growth, reproductive development, and longevity. Physiol Rev. 2013 Apr; 93(2):571-98. Bartke A, Sun LY, Longo V. PMID: 23589828.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    70. Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging Cell. 2013 Apr; 12(2):257-68. Parrella E, Maxim T, Maialetti F, Zhang L, Wan J, Wei M, Cohen P, Fontana L, Longo VD. PMID: 23362919.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    71. Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression. Exp Gerontol. 2013 Oct; 48(10):1120-8. Brandhorst S, Wei M, Hwang S, Morgan TE, Longo VD. PMID: 23454633.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    72. Assessing chronological aging in bacteria. Methods Mol Biol. 2013; 965:421-37. Gonidakis S, Longo VD. PMID: 23296675.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    73. Assessing chronological aging in Saccharomyces cerevisiae. Methods Mol Biol. 2013; 965:463-72. Hu J, Wei M, Mirisola MG, Longo VD. PMID: 23296677.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    74. Aging, nutrient signaling, hematopoietic senescence, and cancer. Crit Rev Oncog. 2013; 18(6):559-71. Balasubramanian P, Longo VD. PMID: 24579735.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    75. GRP78/BiP is a novel downstream target of IGF-1 receptor mediated signaling. J Cell Physiol. 2012 Dec; 227(12):3803-11. Pfaffenbach KT, Pong M, Morgan TE, Wang H, Ott K, Zhou B, Longo VD, Lee AS. PMID: 22422508.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    76. Fasting enhances the response of glioma to chemo- and radiotherapy. PLoS One. 2012; 7(9):e44603. Safdie F, Brandhorst S, Wei M, Wang W, Lee C, Hwang S, Conti PS, Chen TC, Longo VD. PMID: 22984531.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    77. Acetic acid and acidification accelerate chronological and replicative aging in yeast. Cell Cycle. 2012 Oct 01; 11(19):3532-3. Mirisola MG, Longo VD. PMID: 22951542.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    78. Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab. 2012 Jul 03; 16(1):18-31. Longo VD, Shadel GS, Kaeberlein M, Kennedy B. PMID: 22768836.
      View in: PubMed   Mentions: 188     Fields:    Translation:HumansAnimals
    79. Growth factors, nutrient signaling, and cardiovascular aging. Circ Res. 2012 Apr 13; 110(8):1139-50. Fontana L, Vinciguerra M, Longo VD. PMID: 22499903.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    80. Starvation, detoxification, and multidrug resistance in cancer therapy. Drug Resist Updat. 2012 Feb-Apr; 15(1-2):114-22. Lee C, Raffaghello L, Longo VD. PMID: 22391012.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    81. Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci Transl Med. 2012 Mar 07; 4(124):124ra27. Lee C, Raffaghello L, Brandhorst S, Safdie FM, Bianchi G, Martin-Montalvo A, Pistoia V, Wei M, Hwang S, Merlino A, Emionite L, de Cabo R, Longo VD. PMID: 22323820.
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    82. Chronological aging in Saccharomyces cerevisiae. Subcell Biochem. 2012; 57:101-21. Longo VD, Fabrizio P. PMID: 22094419.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    83. Intermittent supplementation with rapamycin as a dietary restriction mimetic. Aging (Albany NY). 2011 Nov; 3(11):1039-40. Longo VD, Fontana L. PMID: 22147496.
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    84. Studying age-dependent genomic instability using the S. cerevisiae chronological lifespan model. J Vis Exp. 2011 Sep 29; (55). Wei M, Madia F, Longo VD. PMID: 21989366.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    85. Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients. Oncogene. 2011 Jul 28; 30(30):3305-16. Lee C, Longo VD. PMID: 21516129.
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    86. Conserved role of Ras-GEFs in promoting aging: from yeast to mice. Aging (Albany NY). 2011 Apr; 3(4):340-3. Mirisola MG, Longo VD. PMID: 21732566.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    87. Metabolic alterations in yeast lacking copper-zinc superoxide dismutase. Free Radic Biol Med. 2011 Jun 01; 50(11):1591-8. Sehati S, Clement MH, Martins J, Xu L, Longo VD, Valentine JS, Gralla EB. PMID: 21397007.
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    88. Lifespan extension and paraquat resistance in a ubiquinone-deficient Escherichia coli mutant depend on transcription factors ArcA and TdcA. Aging (Albany NY). 2011 Mar; 3(3):291-303. Gonidakis S, Finkel SE, Longo VD. PMID: 21464517.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    89. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med. 2011 Feb 16; 3(70):70ra13. Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD. PMID: 21325617.
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    90. Endosomal protein sorting and autophagy genes contribute to the regulation of yeast life span. Autophagy. 2010 Nov; 6(8):1227-8. Longo VD, Nislow C, Fabrizio P. PMID: 20953148.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    91. Fasting and differential chemotherapy protection in patients. Cell Cycle. 2010 Nov 15; 9(22):4474-6. Raffaghello L, Safdie F, Bianchi G, Dorff T, Fontana L, Longo VD. PMID: 21088487.
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    92. E. coli hypoxia-inducible factor ArcA mediates lifespan extension in a lipoic acid synthase mutant by suppressing acetyl-CoA synthetase. Biol Chem. 2010 Oct; 391(10):1139-47. Gonidakis S, Finkel SE, Longo VD. PMID: 20707605.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    93. Genome-wide screen identifies Escherichia coli TCA-cycle-related mutants with extended chronological lifespan dependent on acetate metabolism and the hypoxia-inducible transcription factor ArcA. Aging Cell. 2010 Oct; 9(5):868-81. Gonidakis S, Finkel SE, Longo VD. PMID: 20707865.
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    94. Linking Klotho, Nrf2, MAP kinases and aging. Aging (Albany NY). 2010 Oct; 2(10):632-3. Balasubramanian P, Longo VD. PMID: 21076180.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    95. SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci. 2010 Jul 21; 30(29):9695-707. Michán S, Li Y, Chou MM, Parrella E, Ge H, Long JM, Allard JS, Lewis K, Miller M, Xu W, Mervis RF, Chen J, Guerin KI, Smith LE, McBurney MW, Sinclair DA, Baudry M, de Cabo R, Longo VD. PMID: 20660252.
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    96. Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation. PLoS Genet. 2010 Jul 15; 6(7):e1001024. Fabrizio P, Hoon S, Shamalnasab M, Galbani A, Wei M, Giaever G, Nislow C, Longo VD. PMID: 20657825.
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    97. Cell resilience in species life spans: a link to inflammation? Aging Cell. 2010 Aug; 9(4):519-26. Finch CE, Morgan TE, Longo VD, de Magalhaes JP. PMID: 20415721.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    98. Extending healthy life span--from yeast to humans. Science. 2010 Apr 16; 328(5976):321-6. Fontana L, Partridge L, Longo VD. PMID: 20395504.
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    99. Impact papers on aging in 2009. Aging (Albany NY). 2010 Mar; 2(3):111-21. Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS, Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, Vijg J. PMID: 20351400.
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    100. Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Res. 2010 Feb 15; 70(4):1564-72. Lee C, Safdie FM, Raffaghello L, Wei M, Madia F, Parrella E, Hwang D, Cohen P, Bianchi G, Longo VD. PMID: 20145127.
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    101. Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends Pharmacol Sci. 2010 Feb; 31(2):89-98. Longo VD, Fontana L. PMID: 20097433.
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    102. Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain. ScientificWorldJournal. 2010 Jan 21; 10:161-77. Parrella E, Longo VD. PMID: 20098959.
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    103. Fasting and cancer treatment in humans: A case series report. Aging (Albany NY). 2009 Dec 31; 1(12):988-1007. Safdie FM, Dorff T, Quinn D, Fontana L, Wei M, Lee C, Cohen P, Longo VD. PMID: 20157582.
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    104. Comparative analyses of time-course gene expression profiles of the long-lived sch9Delta mutant. Nucleic Acids Res. 2010 Jan; 38(1):143-58. Ge H, Wei M, Fabrizio P, Hu J, Cheng C, Longo VD, Li LM. PMID: 19880387.
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    105. Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polzeta-dependent mechanism. J Cell Biol. 2009 Aug 24; 186(4):509-23. Madia F, Wei M, Yuan V, Hu J, Gattazzo C, Pham P, Goodman MF, Longo VD. PMID: 19687253.
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    106. Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension. PLoS Genet. 2009 May; 5(5):e1000467. Wei M, Fabrizio P, Madia F, Hu J, Ge H, Li LM, Longo VD. PMID: 19424415.
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    107. Nerve growth factor and its receptors TrkA and p75 are upregulated in the brain of mdx dystrophic mouse. Neuroscience. 2009 Jul 21; 161(4):1057-66. Nico B, Mangieri D, De Luca A, Corsi P, Benagiano V, Tamma R, Annese T, Longo V, Crivellato E, Ribatti D. PMID: 19376199.
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    108. Turning anti-ageing genes against cancer. Nat Rev Mol Cell Biol. 2008 11; 9(11):903-10. Longo VD, Lieber MR, Vijg J. PMID: 18946478.
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    109. The chronological life span of Saccharomyces cerevisiae to study mitochondrial dysfunction and disease. Methods. 2008 Dec; 46(4):256-62. Parrella E, Longo VD. PMID: 18930829.
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    110. SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab. 2008 Jul; 8(1):38-48. Li Y, Xu W, McBurney MW, Longo VD. PMID: 18590691.
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    111. Linking sirtuins, IGF-I signaling, and starvation. Exp Gerontol. 2009 Jan-Feb; 44(1-2):70-4. Longo VD. PMID: 18638538.
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    112. Clodronate inhibits angiogenesis in vitro and in vivo. Oncol Rep. 2008 May; 19(5):1109-12. Ribatti D, Maruotti N, Nico B, Longo V, Mangieri D, Vacca A, Cantatore FP. PMID: 18425365.
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    113. Chronological aging-induced apoptosis in yeast. Biochim Biophys Acta. 2008 Jul; 1783(7):1280-5. Fabrizio P, Longo VD. PMID: 18445486.
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    114. Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proc Natl Acad Sci U S A. 2008 Jun 17; 105(24):8215-20. Raffaghello L, Lee C, Safdie FM, Wei M, Madia F, Bianchi G, Longo VD. PMID: 18378900.
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    115. Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system. J Cell Biol. 2008 Jan 14; 180(1):67-81. Madia F, Gattazzo C, Wei M, Fabrizio P, Burhans WC, Weinberger M, Galbani A, Smith JR, Nguyen C, Huey S, Comai L, Longo VD. PMID: 18195102.
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    116. Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. PLoS Genet. 2008 Jan; 4(1):e13. Wei M, Fabrizio P, Hu J, Ge H, Cheng C, Li L, Longo VD. PMID: 18225956.
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    117. Significant and systematic expression differentiation in long-lived yeast strains. PLoS One. 2007 Oct 31; 2(10):e1095. Cheng C, Fabrizio P, Ge H, Wei M, Longo VD, Li LM. PMID: 17971858.
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    118. Angiogenesis and mast cells in human breast cancer sentinel lymph nodes with and without micrometastases. Histopathology. 2007 Dec; 51(6):837-42. Ribatti D, Finato N, Crivellato E, Guidolin D, Longo V, Mangieri D, Nico B, Vacca A, Beltrami CA. PMID: 17944928.
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    119. Imaging and angiogenesis in hematological malignancies. Leukemia. 2007 Aug; 21(8):1605. Longo V, Vacca A, Ribatti D. PMID: 17637714.
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    120. Inference of transcription modification in long-live yeast strains from their expression profiles. BMC Genomics. 2007 Jul 06; 8:219. Cheng C, Fabrizio P, Ge H, Longo VD, Li LM. PMID: 17617911.
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    121. Erythropoietin/erythropoietin-receptor system is involved in angiogenesis in human hepatocellular carcinoma. Histopathology. 2007 Apr; 50(5):591-6. Ribatti D, Marzullo A, Gentile A, Longo V, Nico B, Vacca A, Dammacco F. PMID: 17394495.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    122. Erythropoietin/erythropoietin receptor system is involved in angiogenesis in human neuroblastoma. Histopathology. 2007 Apr; 50(5):636-41. Ribatti D, Poliani PL, Longo V, Mangieri D, Nico B, Vacca A. PMID: 17394500.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    123. In vivo inhibition of human hepatocellular carcinoma related angiogenesis by vinblastine and rapamycin. Histol Histopathol. 2007 03; 22(3):285-9. Ribatti D, Nico B, Mangieri D, Longo V, Sansonno D, Vacca A, Dammacco F. PMID: 17163402.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    124. Cloning, tissue expression, and inducibility of CYP 3A79 from sea bass (Dicentrarchus labrax). J Biochem Mol Toxicol. 2007; 21(1):32-40. Vaccaro E, Salvetti A, Del Carratore R, Nencioni S, Longo V, Gervasi PG. PMID: 17366542.
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    125. The chronological life span of Saccharomyces cerevisiae. Methods Mol Biol. 2007; 371:89-95. Fabrizio P, Longo VD. PMID: 17634576.
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    126. A simple model system for age-dependent DNA damage and cancer. Mech Ageing Dev. 2007 Jan; 128(1):45-9. Madia F, Gattazzo C, Fabrizio P, Longo VD. PMID: 17118426.
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    127. Neridronate inhibits angiogenesis in vitro and in vivo. Clin Rheumatol. 2007 Jul; 26(7):1094-8. Ribatti D, Nico B, Mangieri D, Maruotti N, Longo V, Vacca A, Cantatore FP. PMID: 17106617.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    128. Sirtuins in aging and age-related disease. Cell. 2006 Jul 28; 126(2):257-68. Longo VD, Kennedy BK. PMID: 16873059.
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    129. Aging as a mitochondria-mediated atavistic program: can aging be switched off? Ann N Y Acad Sci. 2005 Dec; 1057:145-64. Skulachev VP, Longo VD. PMID: 16399892.
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    130. Sir2 blocks extreme life-span extension. Cell. 2005 Nov 18; 123(4):655-67. Fabrizio P, Gattazzo C, Battistella L, Wei M, Cheng C, McGrew K, Longo VD. PMID: 16286010.
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    131. Programmed and altruistic ageing. Nat Rev Genet. 2005 Nov; 6(11):866-72. Longo VD, Mitteldorf J, Skulachev VP. PMID: 16304601.
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    132. Analysis of gene expression profile in yeast aging chronologically. Mech Ageing Dev. 2005 Jan; 126(1):11-6. Fabrizio P, Li L, Longo VD. PMID: 15610757.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    133. Ras: the other pro-aging pathway. Sci Aging Knowledge Environ. 2004 Sep 29; 2004(39):pe36. Longo VD. PMID: 15456908.
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    134. Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae. J Cell Biol. 2004 Sep 27; 166(7):1055-67. Fabrizio P, Battistella L, Vardavas R, Gattazzo C, Liou LL, Diaspro A, Dossen JW, Gralla EB, Longo VD. PMID: 15452146.
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    135. Superoxide inhibits 4Fe-4S cluster enzymes involved in amino acid biosynthesis. Cross-compartment protection by CuZn-superoxide dismutase. J Biol Chem. 2004 Jul 30; 279(31):32055-62. Wallace MA, Liou LL, Martins J, Clement MH, Bailey S, Longo VD, Valentine JS, Gralla EB. PMID: 15166213.
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    136. Search for methuselah genes heats up. Sci Aging Knowledge Environ. 2004 Feb 11; 2004(6):pe6. Longo VD. PMID: 14960761.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    137. Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae. FEBS Lett. 2004 Jan 16; 557(1-3):136-42. Fabrizio P, Pletcher SD, Minois N, Vaupel JW, Longo VD. PMID: 14741356.
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    138. Biodemographic trajectories of age-specific reproliferation from stationary phase in the yeast Saccharomyces cerevisiae seem multiphasic. Mech Ageing Dev. 2003 Dec; 124(10-12):1059-63. Gendron CM, Minois N, Fabrizio P, Longo VD, Pletcher SD, Vaupel JW. PMID: 14659594.
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    139. The Ras and Sch9 pathways regulate stress resistance and longevity. Exp Gerontol. 2003 Jul; 38(7):807-11. Longo VD. PMID: 12855292.
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    140. The chronological life span of Saccharomyces cerevisiae. Aging Cell. 2003 04; 2(2):73-81. Fabrizio P, Longo VD. PMID: 12882320.
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    141. Evolutionary medicine: from dwarf model systems to healthy centenarians? Science. 2003 Feb 28; 299(5611):1342-6. Longo VD, Finch CE. PMID: 12610293.
      View in: PubMed   Mentions: 184     Fields:    Translation:HumansAnimalsCells
    142. Inhibition of cytochrome p450 enzymes by enrofloxacin in the sea bass (Dicentrarchus labrax). Aquat Toxicol. 2003 Jan 10; 62(1):27-33. Vaccaro E, Giorgi M, Longo V, Mengozzi G, Gervasi PG. PMID: 12413791.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    143. 4-Biphenylaldehyde and 9-anthraldehyde: two fluorescent substrates for determining P450 enzyme activities in rat and human. Xenobiotica. 2003 Jan; 33(1):1-11. Marini S, Grasso E, Longo V, Puccini P, Riccardi B, Gervasi PG. PMID: 12519690.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    144. SOD2 functions downstream of Sch9 to extend longevity in yeast. Genetics. 2003 Jan; 163(1):35-46. Fabrizio P, Liou LL, Moy VN, Diaspro A, Valentine JS, Gralla EB, Longo VD. PMID: 12586694.
      View in: PubMed   Mentions: 133     Fields:    Translation:Animals
    145. Genetics of aging and diseases: from rare mutations and model systems to disease prevention. Arch Neurol. 2002 Nov; 59(11):1706-8. Longo VD, Finch CE. PMID: 12433254.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    146. Oxygen? No thanks, I'm on a diet. Sci Aging Knowledge Environ. 2002 Jun 19; 2002(24):pe10. Longo VD. PMID: 14602992.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    147. Regulation of longevity and stress resistance: a molecular strategy conserved from yeast to humans? Cell Mol Life Sci. 2002 Jun; 59(6):903-8. Longo VD, Fabrizio P. PMID: 12169020.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
    148. Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia. J Neurosci. 2002 May 01; 22(9):3484-92. Xie Z, Wei M, Morgan TE, Fabrizio P, Han D, Finch CE, Longo VD. PMID: 11978825.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    149. Regulation of longevity and stress resistance by Sch9 in yeast. Science. 2001 Apr 13; 292(5515):288-90. Fabrizio P, Pozza F, Pletcher SD, Gendron CM, Longo VD. PMID: 11292860.
      View in: PubMed   Mentions: 318     Fields:    Translation:AnimalsCells
    150. Reversible inactivation of superoxide-sensitive aconitase in Abeta1-42-treated neuronal cell lines. J Neurochem. 2000 Nov; 75(5):1977-85. Longo VD, Viola KL, Klein WL, Finch CE. PMID: 11032887.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    151. Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells. Neurobiol Aging. 1999 Sep-Oct; 20(5):479-86. Longo VD. PMID: 10638521.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    152. Mitochondrial superoxide decreases yeast survival in stationary phase. Arch Biochem Biophys. 1999 May 01; 365(1):131-42. Longo VD, Liou LL, Valentine JS, Gralla EB. PMID: 10222047.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    153. Biodemographic trajectories of longevity. Science. 1998 May 08; 280(5365):855-60. Vaupel JW, Carey JR, Christensen K, Johnson TE, Yashin AI, Holm NV, Iachine IA, Kannisto V, Khazaeli AA, Liedo P, Longo VD, Zeng Y, Manton KG, Curtsinger JW. PMID: 9599158.
      View in: PubMed   Mentions: 192     Fields:    Translation:HumansAnimals
    154. Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast. J Cell Biol. 1997 Jun 30; 137(7):1581-8. Longo VD, Ellerby LM, Bredesen DE, Valentine JS, Gralla EB. PMID: 9199172.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimals
    155. Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo. J Biol Chem. 1996 May 24; 271(21):12275-80. Longo VD, Gralla EB, Valentine JS. PMID: 8647826.
      View in: PubMed   Mentions: 146     Fields:    Translation:AnimalsCells
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