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Valter D. Longo, PhD

Photo of Valter D. Longo, PhD
Title(s)Professor of Gerontology and Biological Sciences, Edna M. Jones Chair in Gerontology
SchoolSchool of Gerontology
Address3715 McClintock Avenue, GER 319
University Park Campus
Los Angeles CA 90089-0191
Phone+1 213 740 6212
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    Collapse overview
    Dr. Longo is the Edna Jones Professor in Gerontology and Professor in Biological Science. He is also the Director of the USC Longevity Institute. He is interested in understanding the fundamental mechanisms of aging in yeast, mice and humans by using genetics and biochemistry techniques. He is also interested in identifying the molecular pathways conserved from simple organisms to humans that can be modulated to protect against multiple stresses and treat or prevent cancer , Alzheimer’s Disease and other diseases of aging. The focus is on the signal transudation pathways that regulate resistance to oxidative damage in yeast and mice.

    Collapse Research 
    Collapse research activities and funding
    Dietary Restriction, GH/IGF-1 & Mechanisms of Cellular Protection and Regeneration
    NIH P01AG055369Feb 15, 2018 - Jan 31, 2023
    Role: Principal Investigator
    Interventions to Slow Aging in Humans: Are We Ready?
    NIH R13AG046104Sep 1, 2013 - Aug 31, 2014
    Role: Principal Investigator
    Dietary Restriction, GH/IGF-I & Mechanisms of Differential Cellular Protection
    NIH P01AG034906Mar 15, 2011 - Jul 31, 2017
    Role: Principal Investigator
    Chronological Age-Dependent Genomic Instability in Yeast
    NIH R01AG025135Jul 1, 2006 - Jun 30, 2011
    Role: Principal Investigator
    Role of Longevity Regulatory Pathways in Age-dependent Macro-molecular Damage in
    NIH R01AG020642Apr 1, 2002 - May 31, 2018
    Role: Principal Investigator
    4 iron-4sulfur Clusters in Aging and Alzheimer's Disease
    NIH K01AG001028Sep 30, 2001 - Aug 31, 2005
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A fasting-mimicking diet in patients with mild-to-moderate Crohn's disease: a randomized controlled trial. Nat Med. 2026 Jan 13. Kulkarni C, Fardeen T, Gubatan J, Ye J, Jarr K, Dickson E, Jang H, Temby M, Patel A, Jiang Y, Singh G, Keyashian K, Streett S, Ho E, Barber G, Singh S, Limsui D, Anaizi N, Becker L, Spencer SP, Mehrish D, Perelman D, Longo VD, Charu V, Ashouri JF, Davis MM, Habtezion A, Sonnenburg JL, Gardner C, Sinha SR. PMID: 41530382.
      View in: PubMed   Mentions:    Fields:    
    2. Periodic fasting induced reconstitution of metabolic flexibility improves albuminuria in patients with type 2 diabetes. Mol Metab. 2025 Dec; 102:102257. Sulaj A, Nguyen PBH, Poschet G, Kliemank E, Fleming T, Henke L, Neibig W, Kopf S, Hell R, Longo VD, Herzig S, Nawroth PP, Menden MP, Szendroedi J. PMID: 41005725; PMCID: PMC12546980.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Author Correction: Fasting mimicking diet cycles versus a Mediterranean diet and cardiometabolic risk in overweight and obese hypertensive subjects: a randomized clinical trial. NPJ Metab Health Dis. 2025 Sep 23; 3(1):38. Mishra A, Fanti M, Ge X, Vaughn D, Brandhorst S, Wei M, Hong KM, Pellegrini M, Pijl H, Houston MC, Longo VD. PMID: 40987812; PMCID: PMC12457591.
      View in: PubMed   Mentions:
    4. Caloric restriction protects from acute and chronic kidney injury by inhibiting monocyte recruitment. iScience. 2025 Aug 15; 28(8):113094. Molinari P, Verlato A, Noble J, Alibrandi S, Bin S, Ferrari K, Malvezzi P, Alfieri C, Castellano G, Perin L, Longo V, Cravedi P. PMID: 40755453; PMCID: PMC12314339.
      View in: PubMed   Mentions: 1  
    5. Anaphylaxis trend before and during pandemic: COVID-19 did not affect anaphylaxis frequency. Eur Ann Allergy Clin Immunol. 2025 Apr 29. Sangalli A, Fasiello A, Pravettoni V, Consonni D, Melli V, Jachetti A, Longo V, Montano N, Rivolta F. PMID: 40297907.
      View in: PubMed   Mentions:    Fields:    
    6. Dietary Amino Acids and Risk of Stroke Subtypes: Results from 3 Large Prospective Cohort Studies. J Nutr. 2025 May; 155(5):1560-1569. Tong TY, Li Y, Rexrode KM, Willett WC, Sun Q, Manson JE, Longo VD, Key TJ, Hu FB. PMID: 40127732; PMCID: PMC12121403.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research. Nat Metab. 2025 Mar; 7(3):454-468. Deota S, Pendergast JS, Kolthur-Seetharam U, Esser KA, Gachon F, Asher G, Dibner C, Benitah SA, Escobar C, Muoio DM, Zhang EE, Hotamisligil GS, Bass J, Takahashi JS, Rabinowitz JD, Lamia KA, de Cabo R, Kajimura S, Longo VD, Xu Y, Lazar MA, Verdin E, Zierath JR, Auwerx J, Drucker DJ, Panda S. PMID: 40097742; PMCID: PMC12584160.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    8. Chemosensory and cardiometabolic improvements after a fasting-mimicking diet: A randomized cross-over clinical trial. Cell Rep Med. 2025 Feb 18; 6(2):101971. Micarelli A, Mrakic-Sposta S, Vezzoli A, Malacrida S, Caputo S, Micarelli B, Misici I, Carbini V, Iennaco I, Granito I, Longo VD, Alessandrini M. PMID: 39970875; PMCID: PMC11866515.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Intermittent and periodic fasting in the treatment of obesity and type 2 diabetes mellitus. Nat Rev Endocrinol. 2025 Feb; 21(2):73-74. Longo VD. PMID: 39672887.
      View in: PubMed   Mentions: 2     Fields:    
    10. Fasting-mimicking diet potentiates anti-tumor effects of CDK4/6 inhibitors against breast cancer by suppressing NRAS- and IGF1-mediated mTORC1 signaling. Drug Resist Updat. 2025 Jan; 78:101182. Brandhorst S, Longo VD. PMID: 39665873.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    11. A kidney-specific fasting-mimicking diet induces podocyte reprogramming and restores renal function in glomerulopathy. Sci Transl Med. 2024 10 30; 16(771):eadl5514. Villani V, Frank CN, Cravedi P, Hou X, Bin S, Kamitakahara A, Barbati C, Buono R, Da Sacco S, Lemley KV, De Filippo RE, Lai S, Laviano A, Longo VD, Perin L. PMID: 39475573.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    12. Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity. Aging (Albany NY). 2024 Oct 16; 16(20):12955-12976. Lyu YX, Fu Q, Wilczok D, Ying K, King A, Antebi A, Vojta A, Stolzing A, Moskalev A, Georgievskaya A, Maier AB, Olsen A, Groth A, Simon AK, Brunet A, Jamil A, Kulaga A, Bhatti A, Yaden B, Pedersen BK, Schumacher B, Djordjevic B, Kennedy B, Chen C, Huang CY, Correll CU, Murphy CT, Ewald CY, Chen D, Valenzano DR, Soldacki D, Erritzoe D, Meyer D, Sinclair DA, Chini EN, Teeling EC, Morgen E, Verdin E, Vernet E, Pinilla E, Fang EF, Bischof E, Mercken EM, Finger F, Kuipers F, Pun FW, Gyülveszi G, Civiletto G, Zmudze G, Blander G, Pincus HA, McClure J, Kirkland JL, Peyer J, Justice JN, Vijg J, Gruhn JR, McLaughlin J, Mannick J, Passos J, Baur JA, Betts-LaCroix J, Sedivy JM, Speakman JR, Shlain J, von Maltzahn J, Andreasson KI, Moody K, Palikaras K, Fortney K, Niedernhofer LJ, Rasmussen LJ, Veenhoff LM, Melton L, Ferrucci L, Quarta M, Koval M, Marinova M, Hamalainen M, Unfried M, Ringel MS, Filipovic M, Topors M, Mitin N, Roy N, Pintar N, Barzilai N, Binetti P, Singh P, Kohlhaas P, Robbins PD, Rubin P, Fedichev PO, Kamya P, Muñoz-Canoves P, de Cabo R, Faragher RGA, Konrad R, Ripa R, Mansukhani R, Büttner S, Wickström SA, Brunemeier S, Jakimov S, Luo S, Rosenzweig-Lipson S, Tsai SY, Dimmeler S, Rando TA, Peterson TR, Woods T, Wyss-Coray T, Finkel T, Strauss T, Gladyshev VN, Longo VD, Dwaraka VB, Gorbunova V, Acosta-Rodríguez VA, Sorrentino V, Sebastiano V, Li W, Suh Y, Zhavoronkov A, Scheibye-Knudsen M, Bakula D. PMID: 39418098; PMCID: PMC11552646.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    13. Nutrition, GH/IGF-1 signaling, and cancer. Endocr Relat Cancer. 2024 Nov 01; 31(11). Fanti M, Longo VD. PMID: 39166749; PMCID: PMC11771996.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    14. Cyclic fasting-mimicking diet in cancer treatment: Preclinical and clinical evidence. Cell Metab. 2024 Aug 06; 36(8):1644-1667. Vernieri C, Ligorio F, Tripathy D, Longo VD. PMID: 39059383.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    15. International consensus on fasting terminology. Cell Metab. 2024 Aug 06; 36(8):1779-1794.e4. Koppold DA, Breinlinger C, Hanslian E, Kessler C, Cramer H, Khokhar AR, Peterson CM, Tinsley G, Vernieri C, Bloomer RJ, Boschmann M, Bragazzi NL, Brandhorst S, Gabel K, Goldhamer AC, Grajower MM, Harvie M, Heilbronn L, Horne BD, Karras SN, Langhorst J, Lischka E, Madeo F, Mitchell SJ, Papagiannopoulos-Vatopaidinos IE, Papagiannopoulou M, Pijl H, Ravussin E, Ritzmann-Widderich M, Varady K, Adamidou L, Chihaoui M, de Cabo R, Hassanein M, Lessan N, Longo V, Manoogian ENC, Mattson MP, Muhlestein JB, Panda S, Papadopoulou SK, Rodopaios NE, Stange R, Michalsen A. PMID: 39059384; PMCID: PMC11504329.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    16. A cross-sectional study evaluating the exercise discussion with oncologist during cancer consultation: the CONNECT study. ESMO Open. 2024 Jul; 9(7):103624. Avancini A, Giannarelli D, Borsati A, Carnio S, Cantale O, Nepote A, Mangiapane F, Bafunno D, Galetta D, Longo V, Tregnago D, Trestini I, Belluomini L, Sposito M, Insolda J, Schena F, Milella M, Novello S, Pilotto S, partnership with WALCE (Women Against Lung Cancer in Europe). PMID: 38943736; PMCID: PMC11261275.
      View in: PubMed   Mentions: 3  Translation:Humans
    17. Normal or improved cardiovascular risk factors in IGF-I-deficient adults with growth hormone receptor deficiency. Med. 2024 Jul 12; 5(7):816-825.e4. Guevara-Aguirre J, Mishra A, Canepa M, Guevara C, Villacres Á, Guevara A, Peña G, Lescano D, Kopchick JJ, Balasubramanian P, Longo VD. PMID: 38677286; PMCID: PMC11246805.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Exploring juventology: unlocking the secrets of youthspan and longevity programs. Front Aging. 2024; 5:1379289. Brandhorst S, Longo VD. PMID: 38638872; PMCID: PMC11024265.
      View in: PubMed   Mentions: 1  
    19. Cyclic Fasting-Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia. Cancer Res. 2024 04 01; 84(7):1133-1148. Raucci F, Vernieri C, Di Tano M, Ligorio F, Blaževitš O, Lazzeri S, Shmahala A, Fragale G, Salvadori G, Varano G, Casola S, Buono R, Visco E, de Braud F, Longo VD. PMID: 38241703; PMCID: PMC10982641.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    20. Integration of a fasting-mimicking diet programme in primary care for type 2 diabetes reduces the need for medication and improves glycaemic control: a 12-month randomised controlled trial. Diabetologia. 2024 Jul; 67(7):1245-1259. van den Burg EL, Schoonakker MP, van Peet PG, van den Akker-van Marle EM, Lamb HJ, Longo VD, Numans ME, Pijl H. PMID: 38546821; PMCID: PMC11153305.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    21. Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk. Nat Commun. 2024 Feb 20; 15(1):1309. Brandhorst S, Levine ME, Wei M, Shelehchi M, Morgan TE, Nayak KS, Dorff T, Hong K, Crimmins EM, Cohen P, Longo VD. PMID: 38378685; PMCID: PMC10879164.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    22. Ketone bodies in cell physiology and cancer. Am J Physiol Cell Physiol. 2024 03 01; 326(3):C948-C963. Giuliani G, Longo VD. PMID: 38189128.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    23. Inactivation of Ymr1, Sjl2/3 phosphatases promotes stress resistance and longevity in wild type and Ras2G19V yeast. Biomed J. 2024 04; 47(2):100694. Mirisola MG, Longo VD. PMID: 38154617; PMCID: PMC10950826.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    24. Nutrition and dietary restrictions in cancer prevention. Biochim Biophys Acta Rev Cancer. 2024 01; 1879(1):189063. Mishra A, Giuliani G, Longo VD. PMID: 38147966.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    25. Fasting-Mimicking Diet Inhibits Autophagy and Synergizes with Chemotherapy to Promote T-Cell-Dependent Leukemia-Free Survival. Cancers (Basel). 2023 Dec 16; 15(24). Buono R, Tucci J, Cutri R, Guidi N, Mangul S, Raucci F, Pellegrini M, Mittelman SD, Longo VD. PMID: 38136414; PMCID: PMC10741737.
      View in: PubMed   Mentions: 9  
    26. Fasting mimicking diet cycles versus a Mediterranean diet and cardiometabolic risk in overweight and obese hypertensive subjects: a randomized clinical trial. NPJ Metab Health Dis. 2023 Dec 13; 1(1):1. Mishra A, Fanti M, Ge X, Vaughn D, Brandhorst S, Wei M, Hong KM, Pellegrini M, Pijl H, Houston MC, Longo VD. PMID: 40604264; PMCID: PMC12118742.
      View in: PubMed   Mentions: 1  
    27. Restrictive diets have a beneficial impact on dextran sodium sulfate-induced colitis in male mice. J Nutr. 2024 01; 154(1):121-132. Hadžic K, Gregor A, Auernigg-Haselmaier S, Longo V, Pignitter M, Duszka K. PMID: 37952777.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    28. Fasting mimicking diet in mice delays cancer growth and reduces immunotherapy-associated cardiovascular and systemic side effects. Nat Commun. 2023 09 08; 14(1):5529. Cortellino S, Quagliariello V, Delfanti G, Blaževitš O, Chiodoni C, Maurea N, Di Mauro A, Tatangelo F, Pisati F, Shmahala A, Lazzeri S, Spagnolo V, Visco E, Tripodo C, Casorati G, Dellabona P, Longo VD. PMID: 37684243; PMCID: PMC10491752.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    29. Metabolites and Immune Response in Tumor Microenvironments. Cancers (Basel). 2023 Jul 31; 15(15). Cortellino S, Longo VD. PMID: 37568713; PMCID: PMC10417674.
      View in: PubMed   Mentions: 13  
    30. Biology of Stress Responses in Aging. Aging Biol. 2023; 1. Maragkakis M, Malla S, Hatzoglou M, Trifunovic A, Glick AB, Finkel T, Longo VD, Kaushik S, Muñoz-Cánoves P, Lithgow GJ, Naidoo N, Booth LN, Payea MJ, Herman AB, de Cabo R, Wilson DM, Ferrucci L, Gorospe M. PMID: 38500537; PMCID: PMC10947073.
      View in: PubMed   Mentions: 2  
    31. Correction: The impact of a fasting mimicking diet on the metabolic health of a prospective cohort of patients with prostate cancer: a pilot implementation study. Prostate Cancer Prostatic Dis. 2023 Jun; 26(2):435. Fay-Watt V, O'Connor S, Roshan D, Romeo AC, Longo VD, Sullivan FJ. PMID: 35585259; PMCID: PMC10247363.
      View in: PubMed   Mentions: 2     Fields:    
    32. Could dietary restrictions affect periodontal disease? A systematic review. Clin Oral Investig. 2023 Aug; 27(8):4107-4116. Mainas G, Santamaria P, Ide M, Longo V, Vinciguerra M, Nart J, Nibali L. PMID: 37199773; PMCID: PMC10415456.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    33. Six-month periodic fasting does not affect somatosensory nerve function in type 2 diabetes patients. Front Endocrinol (Lausanne). 2023; 14:1143799. Kender Z, von Rauchhaupt E, Schwarz D, Tsilingiris D, Schimpfle L, Bartl H, Longo VD, Bendszus M, Kopf S, Herzig S, Heiland S, Szendroedi J, Sulaj A. PMID: 37251671; PMCID: PMC10213657.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    34. Fasting and fasting mimicking diets in cancer prevention and therapy. Trends Cancer. 2023 03; 9(3):212-222. Blaževitš O, Di Tano M, Longo VD. PMID: 36646607.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    35. Presence, enzymatic activity, and subcellular localization of paraoxonases 1, 2, and 3 in human lung tissues. Life Sci. 2022 Dec 15; 311(Pt A):121147. Cavallero A, Puccini P, Aprile V, Lucchi M, Gervasi PG, Longo V, Gabriele M. PMID: 36336126.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    36. Breakfast keeps hunger in check. Cell Metab. 2022 10 04; 34(10):1420-1421. Brandhorst S, Longo VD. PMID: 36198286.
      View in: PubMed   Mentions: 1     Fields:    
    37. Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models. Cell Rep. 2022 09 27; 40(13):111417. Rangan P, Lobo F, Parrella E, Rochette N, Morselli M, Stephen TL, Cremonini AL, Tagliafico L, Persia A, Caffa I, Monacelli F, Odetti P, Bonfiglio T, Nencioni A, Pigliautile M, Boccardi V, Mecocci P, Pike CJ, Cohen P, LaDu MJ, Pellegrini M, Xia K, Tran K, Ann B, Chowdhury D, Longo VD. PMID: 36170815; PMCID: PMC9648488.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    38. Fasting renders immunotherapy effective against low-immunogenic breast cancer while reducing side effects. Cell Rep. 2022 08 23; 40(8):111256. Cortellino S, Raveane A, Chiodoni C, Delfanti G, Pisati F, Spagnolo V, Visco E, Fragale G, Ferrante F, Magni S, Iannelli F, Zanardi F, Casorati G, Bertolini F, Dellabona P, Colombo MP, Tripodo C, Longo VD. PMID: 36001966.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    39. A Comparison of the Impact of Restrictive Diets on the Gastrointestinal Tract of Mice. Nutrients. 2022 Jul 29; 14(15). Gregor A, Huber L, Auernigg-Haselmaier S, Sternberg F, Billerhart M, Dunkel A, Somoza V, Ogris M, Kofler B, Longo VD, König J, Duszka K. PMID: 35956298; PMCID: PMC9370610.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    40. Six-Month Periodic Fasting in Patients With Type 2 Diabetes and Diabetic Nephropathy: A Proof-of-Concept Study. J Clin Endocrinol Metab. 2022 07 14; 107(8):2167-2181. Sulaj A, Kopf S, von Rauchhaupt E, Kliemank E, Brune M, Kender Z, Bartl H, Cortizo FG, Klepac K, Han Z, Kumar V, Longo V, Teleman A, Okun JG, Morgenstern J, Fleming T, Szendroedi J, Herzig S, Nawroth PP. PMID: 35661214; PMCID: PMC9282263.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    41. Fasting and Fasting Mimicking Diets in Obesity and Cardiometabolic Disease Prevention and Treatment. Phys Med Rehabil Clin N Am. 2022 08; 33(3):699-717. Mishra A, Longo VD. PMID: 35989059.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    42. Fasting and cancer: from yeast to mammals. Int Rev Cell Mol Biol. 2022; 373:81-106. Di Tano M, Longo VD. PMID: 36283768.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    43. Yeast Chronological Lifespan: Longevity Regulatory Genes and Mechanisms. Cells. 2022 05 23; 11(10). Mirisola MG, Longo VD. PMID: 35626750; PMCID: PMC9139625.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    44. Nutrition, longevity and disease: From molecular mechanisms to interventions. Cell. 2022 04 28; 185(9):1455-1470. Longo VD, Anderson RM. PMID: 35487190; PMCID: PMC9089818.
      View in: PubMed   Mentions: 146     Fields:    
    45. The impact of a fasting mimicking diet on the metabolic health of a prospective cohort of patients with prostate cancer: a pilot implementation study. Prostate Cancer Prostatic Dis. 2023 06; 26(2):317-322. Fay-Watt V, O'Connor S, Roshan D, Romeo AC, Longo VD, Sullivan FJ. PMID: 35314788; PMCID: PMC10247368.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    46. Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis. Aging Cell. 2022 02; 21(2):e13540. Rahmani J, Montesanto A, Giovannucci E, Zand H, Barati M, Kopchick JJ, Mirisola MG, Lagani V, Bawadi H, Vardavas R, Laviano A, Christensen K, Passarino G, Longo VD. PMID: 35048526; PMCID: PMC8844108.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    47. Fasting-Mimicking-Diet does not reduce skeletal muscle function in healthy young adults: a randomized control trial. Eur J Appl Physiol. 2022 Mar; 122(3):651-661. Nardon M, Venturelli M, Ruzzante F, Longo VD, Bertucco M. PMID: 35034194.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    48. Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer. Cancer Discov. 2022 01; 12(1):90-107. Vernieri C, Fucà G, Ligorio F, Huber V, Vingiani A, Iannelli F, Raimondi A, Rinchai D, Frigè G, Belfiore A, Lalli L, Chiodoni C, Cancila V, Zanardi F, Ajazi A, Cortellino S, Vallacchi V, Squarcina P, Cova A, Pesce S, Frati P, Mall R, Corsetto PA, Rizzo AM, Ferraris C, Folli S, Garassino MC, Capri G, Bianchi G, Colombo MP, Minucci S, Foiani M, Longo VD, Apolone G, Torri V, Pruneri G, Bedognetti D, Rivoltini L, de Braud F. PMID: 34789537; PMCID: PMC9762338.
      View in: PubMed   Mentions: 155     Fields:    Translation:HumansCTClinical Trials
    49. Diet composition influences the metabolic benefits of short cycles of very low caloric intake. Nat Commun. 2021 11 09; 12(1):6463. Diaz-Ruiz A, Rhinesmith T, Pomatto-Watson LCD, Price NL, Eshaghi F, Ehrlich MR, Moats JM, Carpenter M, Rudderow A, Brandhorst S, Mattison JA, Aon MA, Bernier M, Longo VD, de Cabo R. PMID: 34753921; PMCID: PMC8578605.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    50. Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape. Cell Metab. 2021 11 02; 33(11):2247-2259.e6. Salvadori G, Zanardi F, Iannelli F, Lobefaro R, Vernieri C, Longo VD. PMID: 34731655; PMCID: PMC8769166.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    51. Diet comparison suggests a lipid imbalance can slow tumour growth. Nature. 2021 11; 599(7884):206-207. Salvadori G, Longo VD. PMID: 34671149.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    52. Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition. Nat Commun. 2021 10 27; 12(1):6201. Pomatto-Watson LCD, Bodogai M, Bosompra O, Kato J, Wong S, Carpenter M, Duregon E, Chowdhury D, Krishna P, Ng S, Ragonnaud E, Salgado R, Gonzalez Ericsson P, Diaz-Ruiz A, Bernier M, Price NL, Biragyn A, Longo VD, de Cabo R. PMID: 34707136; PMCID: PMC8551193.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    53. Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan. Nat Metab. 2021 10; 3(10):1342-1356. Mishra A, Mirzaei H, Guidi N, Vinciguerra M, Mouton A, Linardic M, Rappa F, Barone R, Navarrete G, Wei M, Brandhorst S, Di Biase S, Morgan TE, Ram Kumar S, Conti PS, Pellegrini M, Bernier M, de Cabo R, Longo VD. PMID: 34650272.
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    54. Intermittent and Periodic Fasting, Hormones, and Cancer Prevention. Cancers (Basel). 2021 Sep 13; 13(18). Salvadori G, Mirisola MG, Longo VD. PMID: 34572814; PMCID: PMC8472354.
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    55. Safety and Feasibility of Fasting-Mimicking Diet and Effects on Nutritional Status and Circulating Metabolic and Inflammatory Factors in Cancer Patients Undergoing Active Treatment. Cancers (Basel). 2021 Aug 09; 13(16). Valdemarin F, Caffa I, Persia A, Cremonini AL, Ferrando L, Tagliafico L, Tagliafico A, Guijarro A, Carbone F, Ministrini S, Bertolotto M, Becherini P, Bonfiglio T, Giannotti C, Khalifa A, Ghanem M, Cea M, Sucameli M, Murialdo R, Barbero V, Gradaschi R, Bruzzone F, Borgarelli C, Lambertini M, Vernieri C, Zoppoli G, Longo VD, Montecucco F, Sukkar SG, Nencioni A. PMID: 34439167; PMCID: PMC8391327.
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    56. Strategies to Prevent or Remediate Cancer and Treatment-Related Aging. J Natl Cancer Inst. 2021 02 01; 113(2):112-122. Guida JL, Agurs-Collins T, Ahles TA, Campisi J, Dale W, Demark-Wahnefried W, Dietrich J, Fuldner R, Gallicchio L, Green PA, Hurria A, Janelsins MC, Jhappan C, Kirkland JL, Kohanski R, Longo V, Meydani S, Mohile S, Niedernhofer LJ, Nelson C, Perna F, Schadler K, Scott JM, Schrack JA, Tracy RP, van Deursen J, Ness KK. PMID: 32348501; PMCID: PMC7850536.
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    57. Time-Restricted Eating, Intermittent Fasting, and Fasting-Mimicking Diets in Weight Loss. Curr Obes Rep. 2021 Jun; 10(2):70-80. Fanti M, Mishra A, Longo VD, Brandhorst S. PMID: 33512641.
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    58. Intermittent and periodic fasting, longevity and disease. Nat Aging. 2021 01; 1(1):47-59. Longo VD, Di Tano M, Mattson MP, Guidi N. PMID: 35310455; PMCID: PMC8932957.
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    59. Periodic and Intermittent Fasting in Diabetes and Cardiovascular Disease. Curr Diab Rep. 2020 12 10; 20(12):83. Crupi AN, Haase J, Brandhorst S, Longo VD. PMID: 33301104.
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    60. Author Correction: Fasting-mimicking diet and hormone therapy induce breast cancer regression. Nature. 2020 Dec; 588(7839):E33. Caffa I, Spagnolo V, Vernieri C, Valdemarin F, Becherini P, Wei M, Brandhorst S, Zucal C, Driehuis E, Ferrando L, Piacente F, Tagliafico A, Cilli M, Mastracci L, Vellone VG, Piazza S, Cremonini AL, Gradaschi R, Mantero C, Passalacqua M, Ballestrero A, Zoppoli G, Cea M, Arrighi A, Odetti P, Monacelli F, Salvadori G, Cortellino S, Clevers H, De Braud F, Sukkar SG, Provenzani A, Longo VD, Nencioni A. PMID: 33273708.
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    61. Quality of life and illness perceptions in patients with breast cancer using a fasting mimicking diet as an adjunct to neoadjuvant chemotherapy in the phase 2 DIRECT (BOOG 2013-14) trial. Breast Cancer Res Treat. 2021 Feb; 185(3):741-758. Lugtenberg RT, de Groot S, Kaptein AA, Fischer MJ, Kranenbarg EM, Carpentier MD, Cohen D, de Graaf H, Heijns JB, Portielje JEA, van de Wouw AJ, Imholz ALT, Kessels LW, Vrijaldenhoven S, Baars A, Fiocco M, van der Hoeven JJM, Gelderblom H, Longo VD, Pijl H, Kroep JR, Dutch Breast Cancer Research Group (BOOG). PMID: 33179154; PMCID: PMC7921018.
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    62. Correction to: Fasting in diabetes treatment (FIT) trial: study protocol for a randomised, controlled, assessor-blinded intervention trial on the effects of intermittent use of a fasting-mimicking diet in patients with type 2 diabetes. BMC Endocr Disord. 2020 Nov 04; 20(1):164. van den Burg EL, Schoonakker MP, van Peet PG, van den Akker-van Marle ME, van Dijk KW, Longo VD, Lamb HJ, Numans ME, Pijl H. PMID: 33143722; PMCID: PMC7641833.
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    63. Fasting, dietary restriction, and immunosenescence. J Allergy Clin Immunol. 2020 11; 146(5):1002-1004. Longo VD, Cortellino S. PMID: 32853639.
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    64. A Distinct Brain-Gut-Microbiome Profile Exists for Females with Obesity and Food Addiction. Obesity (Silver Spring). 2020 08; 28(8):1477-1486. Dong TS, Mayer EA, Osadchiy V, Chang C, Katzka W, Lagishetty V, Gonzalez K, Kalani A, Stains J, Jacobs JP, Longo VD, Gupta A. PMID: 32935533; PMCID: PMC7494955.
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    65. A fasting-mimicking diet and vitamin C: turning anti-aging strategies against cancer. Mol Cell Oncol. 2020; 7(5):1791671. Di Tano M, Longo VD. PMID: 32944646; PMCID: PMC7469657.
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    66. Fasting-mimicking diet and hormone therapy induce breast cancer regression. Nature. 2020 07; 583(7817):620-624. Caffa I, Spagnolo V, Vernieri C, Valdemarin F, Becherini P, Wei M, Brandhorst S, Zucal C, Driehuis E, Ferrando L, Piacente F, Tagliafico A, Cilli M, Mastracci L, Vellone VG, Piazza S, Cremonini AL, Gradaschi R, Mantero C, Passalacqua M, Ballestrero A, Zoppoli G, Cea M, Arrighi A, Odetti P, Monacelli F, Salvadori G, Cortellino S, Clevers H, De Braud F, Sukkar SG, Provenzani A, Longo VD, Nencioni A. PMID: 32669709; PMCID: PMC7881940.
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    67. Fasting in diabetes treatment (FIT) trial: study protocol for a randomised, controlled, assessor-blinded intervention trial on the effects of intermittent use of a fasting-mimicking diet in patients with type 2 diabetes. BMC Endocr Disord. 2020 Jun 24; 20(1):94. van den Burg EL, Schoonakker MP, van Peet PG, van den Akker-van Marle ME, Willems van Dijk K, Longo VD, Lamb HJ, Numans ME, Pijl H. PMID: 32580710; PMCID: PMC7315472.
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    68. The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan. Aging (Albany NY). 2020 06 23; 12(12):11185-11199. Yen K, Mehta HH, Kim SJ, Lue Y, Hoang J, Guerrero N, Port J, Bi Q, Navarrete G, Brandhorst S, Lewis KN, Wan J, Swerdloff R, Mattison JA, Buffenstein R, Breton CV, Wang C, Longo V, Atzmon G, Wallace D, Barzilai N, Cohen P. PMID: 32575074; PMCID: PMC7343442.
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    69. Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial. Nat Commun. 2020 06 23; 11(1):3083. de Groot S, Lugtenberg RT, Cohen D, Welters MJP, Ehsan I, Vreeswijk MPG, Smit VTHBM, de Graaf H, Heijns JB, Portielje JEA, van de Wouw AJ, Imholz ALT, Kessels LW, Vrijaldenhoven S, Baars A, Kranenbarg EM, Carpentier MD, Putter H, van der Hoeven JJM, Nortier JWR, Longo VD, Pijl H, Kroep JR, Dutch Breast Cancer Research Group (BOOG). PMID: 32576828; PMCID: PMC7311547.
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    70. Efficacy of a fasting-mimicking diet in functional therapy for depression: A randomised controlled pilot trial. J Clin Psychol. 2020 10; 76(10):1807-1817. Maniaci G, La Cascia C, Giammanco A, Ferraro L, Chianetta R, Di Peri R, Sardella Z, Citarrella R, Mannella Y, Larcan S, Montana S, Mirisola MG, Longo V, Rizzo M, La Barbera D. PMID: 32394438.
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    71. Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers. Nat Commun. 2020 05 11; 11(1):2332. Di Tano M, Raucci F, Vernieri C, Caffa I, Buono R, Fanti M, Brandhorst S, Curigliano G, Nencioni A, de Braud F, Longo VD. PMID: 32393788; PMCID: PMC7214421.
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    72. Growth hormone receptor deficiency in humans associates to obesity, increased body fat percentage, a healthy brain and a coordinated insulin sensitivity. Growth Horm IGF Res. 2020 04; 51:58-64. Guevara-Aguirre J, Teran E, Lescano D, Guevara A, Guevara C, Longo V, Gavilanes AWD. PMID: 32145513.
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    73. Protein Quantity and Source, Fasting-Mimicking Diets, and Longevity. Adv Nutr. 2019 11 01; 10(Suppl_4):S340-S350. Brandhorst S, Longo VD. PMID: 31728501; PMCID: PMC6855936.
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    74. Changes in growth hormone secretion and leptin receptor mRNA expression under the influence of leptin and adrenocorticotropin in pituitary cells of early weaned ewe lambs. J Physiol Pharmacol. 2019 Aug; 70(4). Kosior-Korzecka U, Wojcik M, Longo V, Puzio I, Nowakiewicz A, Patkowski K, Gregula-Kania M. PMID: 31642814.
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    75. In vitro profiling of endothelial volatile organic compounds under resting and pro-inflammatory conditions. Metabolomics. 2019 10 03; 15(10):132. Longo V, Forleo A, Capone S, Scoditti E, Carluccio MA, Siciliano P, Massaro M. PMID: 31583479.
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    76. When Fasting Gets Tough, the Tough Immune Cells Get Going-or Die. Cell. 2019 08 22; 178(5):1038-1040. Buono R, Longo VD. PMID: 31442398; PMCID: PMC7474734.
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    77. Dietary Restrictions and Nutrition in the Prevention and Treatment of Cardiovascular Disease. Circ Res. 2019 03 15; 124(6):952-965. Brandhorst S, Longo VD. PMID: 30870119.
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    78. Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology. Cell Rep. 2019 03 05; 26(10):2704-2719.e6. Rangan P, Choi I, Wei M, Navarrete G, Guen E, Brandhorst S, Enyati N, Pasia G, Maesincee D, Ocon V, Abdulridha M, Longo VD. PMID: 30840892; PMCID: PMC6528490.
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    79. Reply to 'Fasting in oncology: a word of caution'. Nat Rev Cancer. 2019 03; 19(3):178. Nencioni A, Caffa I, Cortellino S, Longo VD. PMID: 30651605.
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    80. Fasting and cancer: molecular mechanisms and clinical application. Nat Rev Cancer. 2018 11; 18(11):707-719. Nencioni A, Caffa I, Cortellino S, Longo VD. PMID: 30327499; PMCID: PMC6938162.
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    81. Programmed longevity, youthspan, and juventology. Aging Cell. 2019 02; 18(1):e12843. Longo VD. PMID: 30334314; PMCID: PMC6351819.
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    82. Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans. Sci Rep. 2018 09 21; 8(1):14212. Yen K, Wan J, Mehta HH, Miller B, Christensen A, Levine ME, Salomon MP, Brandhorst S, Xiao J, Kim SJ, Navarrete G, Campo D, Harry GJ, Longo V, Pike CJ, Mack WJ, Hodis HN, Crimmins EM, Cohen P. PMID: 30242290; PMCID: PMC6154958.
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    83. Periodic fasting starves cisplatin-resistant cancers to death. EMBO J. 2018 07 13; 37(14). Guidi N, Longo VD. PMID: 29875131; PMCID: PMC6043846.
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    84. Starvation, Stress Resistance, and Cancer. Trends Endocrinol Metab. 2018 04; 29(4):271-280. Buono R, Longo VD. PMID: 29463451; PMCID: PMC7477630.
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    85. Interview with Professor Valter Longo. FEMS Yeast Res. 2017 Nov 23. Longo V. PMID: 29186374.
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    86. Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production. Cell Metab. 2017 Jun 06; 25(6):1320-1333.e5. Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, Fisher FM, Pissios P, Withers DJ, Selman C, Wang R, Yen K, Longo VD, Cohen P, Bartke A, Kopchick JJ, Miller R, Hollenberg AN, Mitchell JR. PMID: 28591635; PMCID: PMC5722247.
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    87. Correction: Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy. PLoS Biol. 2017 May; 15(5):e1002603. Di Biase S, Shim HS, Kim KH, Vinciguerra M, Rappa F, Wei M, Brandhorst S, Cappello F, Mirzaei H, Lee C, Longo VD. PMID: 28459830; PMCID: PMC5411024.
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    88. Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy. PLoS Biol. 2017 03; 15(3):e2001951. Di Biase S, Shim HS, Kim KH, Vinciguerra M, Rappa F, Wei M, Brandhorst S, Cappello F, Mirzaei H, Lee C, Longo VD. PMID: 28358805; PMCID: PMC5373519.
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    89. Metabolic Alterations at the Crossroad of Aging and Oncogenesis. Int Rev Cell Mol Biol. 2017; 332:1-42. Raffaghello L, Longo V. PMID: 28526131; PMCID: PMC7474736.
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    90. Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes. Cell. 2017 02 23; 168(5):775-788.e12. Cheng CW, Villani V, Buono R, Wei M, Kumar S, Yilmaz OH, Cohen P, Sneddon JB, Perin L, Longo VD. PMID: 28235195; PMCID: PMC5357144.
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    91. Protective effects of short-term dietary restriction in surgical stress and chemotherapy. Ageing Res Rev. 2017 Oct; 39:68-77. Brandhorst S, Harputlugil E, Mitchell JR, Longo VD. PMID: 28216454; PMCID: PMC5722209.
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    92. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Sci Transl Med. 2017 02 15; 9(377). Wei M, Brandhorst S, Shelehchi M, Mirzaei H, Cheng CW, Budniak J, Groshen S, Mack WJ, Guen E, Di Biase S, Cohen P, Morgan TE, Dorff T, Hong K, Michalsen A, Laviano A, Longo VD. PMID: 28202779; PMCID: PMC6816332.
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    93. Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice. Sci Rep. 2017 02 01; 7:40919. Lee AS, Brandhorst S, Rangel DF, Navarrete G, Cohen P, Longo VD, Chen J, Groshen S, Morgan TE, Dubeau L. PMID: 28145503; PMCID: PMC5286507.
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    94. Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence. Mol Cell Endocrinol. 2017 Nov 05; 455:4-12. Choi IY, Lee C, Longo VD. PMID: 28137612; PMCID: PMC5862044.
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    95. Brain Structure and Function Associated with Younger Adults in Growth Hormone Receptor-Deficient Humans. J Neurosci. 2017 02 15; 37(7):1696-1707. Nashiro K, Guevara-Aguirre J, Braskie MN, Hafzalla GW, Velasco R, Balasubramanian P, Wei M, Thompson PM, Mather M, Nelson MD, Guevara A, Teran E, Longo VD. PMID: 28073935; PMCID: PMC5320603.
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    96. Enhancing Stem Cell Transplantation with "Nutri-technology". Cell Stem Cell. 2016 12 01; 19(6):681-682. Longo VD, Cortellino S. PMID: 27912088; PMCID: PMC7474735.
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    97. Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions. Cancer Discov. 2016 12; 6(12):1315-1333. Vernieri C, Casola S, Foiani M, Pietrantonio F, de Braud F, Longo V. PMID: 27872127; PMCID: PMC5140697.
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    98. Impact of intermittent fasting on health and disease processes. Ageing Res Rev. 2017 Oct; 39:46-58. Mattson MP, Longo VD, Harvie M. PMID: 27810402; PMCID: PMC5411330.
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    99. Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality. JAMA Intern Med. 2016 Oct 01; 176(10):1453-1463. Song M, Fung TT, Hu FB, Willett WC, Longo VD, Chan AT, Giovannucci EL. PMID: 27479196; PMCID: PMC5048552.
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    100. Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity. Cancer Cell. 2016 07 11; 30(1):136-146. Di Biase S, Lee C, Brandhorst S, Manes B, Buono R, Cheng CW, Cacciottolo M, Martin-Montalvo A, de Cabo R, Wei M, Morgan TE, Longo VD. PMID: 27411588; PMCID: PMC5388544.
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    101. Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan. Cell Metab. 2016 06 14; 23(6):1048-1059. Longo VD, Panda S. PMID: 27304506; PMCID: PMC5388543.
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    102. Safety and feasibility of fasting in combination with platinum-based chemotherapy. BMC Cancer. 2016 06 10; 16:360. Dorff TB, Groshen S, Garcia A, Shah M, Tsao-Wei D, Pham H, Cheng CW, Brandhorst S, Cohen P, Wei M, Longo V, Quinn DI. PMID: 27282289; PMCID: PMC4901417.
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    103. A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms. Cell Rep. 2016 06 07; 15(10):2136-2146. Choi IY, Piccio L, Childress P, Bollman B, Ghosh A, Brandhorst S, Suarez J, Michalsen A, Cross AH, Morgan TE, Wei M, Paul F, Bock M, Longo VD. PMID: 27239035; PMCID: PMC4899145.
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    104. Dietary Interventions, Cardiovascular Aging, and Disease: Animal Models and Human Studies. Circ Res. 2016 05 13; 118(10):1612-25. Mirzaei H, Di Biase S, Longo VD. PMID: 27174953.
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    105. Soluble endothelial protein C receptor (sEPCR) as an inflammatory biomarker in naive HIV-infected patients during ART. J Antimicrob Chemother. 2016 06; 71(6):1627-31. Chiappetta S, Ripa M, Galli L, Razzari C, Longo V, Galli A, Faioni EM, Nozza S, Lazzarin A, Tambussi G. PMID: 26888911.
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    106. Dietary restriction with and without caloric restriction for healthy aging. F1000Res. 2016; 5. Lee C, Longo V. PMID: 26918181; PMCID: PMC4755412.
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    107. Growth factors, aging and age-related diseases. Growth Horm IGF Res. 2016 06; 28:66-8. Balasubramanian P, Longo VD. PMID: 26883276; PMCID: PMC5455771.
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    108. The conserved role of protein restriction in aging and disease. Curr Opin Clin Nutr Metab Care. 2016 Jan; 19(1):74-9. Mirzaei H, Raynes R, Longo VD. PMID: 26560522; PMCID: PMC4807119.
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    109. Fasting and Caloric Restriction in Cancer Prevention and Treatment. Recent Results Cancer Res. 2016; 207:241-66. Brandhorst S, Longo VD. PMID: 27557543; PMCID: PMC7476366.
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    110. Fasting-induced differential stress sensitization in cancer treatment. Mol Cell Oncol. 2016 May; 3(3):e1117701. Di Biase S, Longo VD. PMID: 27314084; PMCID: PMC4909408.
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    111. Fasting plus tyrosine kinase inhibitors in cancer. Aging (Albany NY). 2015 Dec; 7(12):1026-7. Caffa I, Longo VD, Nencioni A. PMID: 26645151; PMCID: PMC4712327.
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    112. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin Cancer Biol. 2015 Dec; 35 Suppl:S276-S304. Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin ARMR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker WK, Dhawan P, Diehl AME, Dong JT, Dou QP, Drew JE, Elkord E, El-Rayes B, Feitelson MA, Felsher DW, Ferguson LR, Fimognari C, Firestone GL, Frezza C, Fujii H, Fuster MM, Generali D, Georgakilas AG, Gieseler F, Gilbertson M, Green MF, Grue B, Guha G, Halicka D, Helferich WG, Heneberg P, Hentosh P, Hirschey MD, Hofseth LJ, Holcombe RF, Honoki K, Hsu HY, Huang GS, Jensen LD, Jiang WG, Jones LW, Karpowicz PA, Keith WN, Kerkar SP, Khan GN, Khatami M, Ko YH, Kucuk O, Kulathinal RJ, Kumar NB, Kwon BS, Le A, Lea MA, Lee HY, Lichtor T, Lin LT, Locasale JW, Lokeshwar BL, Longo VD, Lyssiotis CA, MacKenzie KL, Malhotra M, Marino M, Martinez-Chantar ML, Matheu A, Maxwell C, McDonnell E, Meeker AK, Mehrmohamadi M, Mehta K, Michelotti GA, Mohammad RM, Mohammed SI, Morre DJ, Muralidhar V, Muqbil I, Murphy MP, Nagaraju GP, Nahta R, Niccolai E, Nowsheen S, Panis C, Pantano F, Parslow VR, Pawelec G, Pedersen PL, Poore B, Poudyal D, Prakash S, Prince M, Raffaghello L, Rathmell JC, Rathmell WK, Ray SK, Reichrath J, Rezazadeh S, Ribatti D, Ricciardiello L, Robey RB, Rodier F, Rupasinghe HPV, Russo GL, Ryan EP, Samadi AK, Sanchez-Garcia I, Sanders AJ, Santini D, Sarkar M, Sasada T, Saxena NK, Shackelford RE, Shantha Kumara HMC, Sharma D, Shin DM, Sidransky D, Siegelin MD, Signori E, Singh N, Sivanand S, Sliva D, Smythe C, Spagnuolo C, Stafforini DM, Stagg J, Subbarayan PR, Sundin T, Talib WH, Thompson SK, Tran PT, Ungefroren H, Vander Heiden MG, Venkateswaran V, Vinay DS, Vlachostergios PJ, Wang Z, Wellen KE, Whelan RL, Yang ES, Yang H, Yang X, Yaswen P, Yedjou C, Yin X, Zhu J, Zollo M. PMID: 26590477; PMCID: PMC4819002.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansCells
    113. Dysregulated metabolism contributes to oncogenesis. Semin Cancer Biol. 2015 Dec; 35 Suppl:S129-S150. Hirschey MD, DeBerardinis RJ, Diehl AME, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell E, Mehrmohamadi M, Michelotti G, Muralidhar V, Murphy MP, Pedersen PL, Poore B, Raffaghello L, Rathmell JC, Sivanand S, Vander Heiden MG, Wellen KE, Target Validation Team. PMID: 26454069; PMCID: PMC4656121.
      View in: PubMed   Mentions: 184     Fields:    Translation:HumansCells
    114. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab. 2015 Jul 07; 22(1):86-99. Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD. PMID: 26094889; PMCID: PMC4509734.
      View in: PubMed   Mentions: 435     Fields:    Translation:HumansAnimals
    115. Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models. Oncotarget. 2015 May 20; 6(14):11806-19. Bianchi G, Martella R, Ravera S, Marini C, Capitanio S, Orengo A, Emionite L, Lavarello C, Amaro A, Petretto A, Pfeffer U, Sambuceti G, Pistoia V, Raffaghello L, Longo VD. PMID: 25909219; PMCID: PMC4494906.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    116. Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition. Oncotarget. 2015 May 20; 6(14):11820-32. Caffa I, D'Agostino V, Damonte P, Soncini D, Cea M, Monacelli F, Odetti P, Ballestrero A, Provenzani A, Longo VD, Nencioni A. PMID: 25909220; PMCID: PMC4494907.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    117. GH Receptor Deficiency in Ecuadorian Adults Is Associated With Obesity and Enhanced Insulin Sensitivity. J Clin Endocrinol Metab. 2015 Jul; 100(7):2589-96. Guevara-Aguirre J, Rosenbloom AL, Balasubramanian P, Teran E, Guevara-Aguirre M, Guevara C, Procel P, Alfaras I, De Cabo R, Di Biase S, Narvaez L, Saavedra J, Longo VD. PMID: 25985182; PMCID: PMC4490304.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    118. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell. 2015 Aug; 14(4):497-510. Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L. PMID: 25902704; PMCID: PMC4531065.
      View in: PubMed   Mentions: 295     Fields:    Translation:HumansAnimalsCells
    119. Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells. Cancer Res. 2015 Mar 15; 75(6):1056-67. Shim HS, Wei M, Brandhorst S, Longo VD. PMID: 25614517; PMCID: PMC4359966.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    120. A protein restriction-dependent sulfur code for longevity. Cell. 2015 Jan 15; 160(1-2):15-7. Shim HS, Longo VD. PMID: 25594171.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    121. Meal frequency and timing in health and disease. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):16647-53. Mattson MP, Allison DB, Fontana L, Harvie M, Longo VD, Malaisse WJ, Mosley M, Notterpek L, Ravussin E, Scheer FA, Seyfried TN, Varady KA, Panda S. PMID: 25404320; PMCID: PMC4250148.
      View in: PubMed   Mentions: 238     Fields:    Translation:Humans
    122. Protein and amino acid restriction, aging and disease: from yeast to humans. Trends Endocrinol Metab. 2014 Nov; 25(11):558-66. Mirzaei H, Suarez JA, Longo VD. PMID: 25153840; PMCID: PMC4254277.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansAnimalsCells
    123. Medical research: treat ageing. Nature. 2014 Jul 24; 511(7510):405-7. Fontana L, Kennedy BK, Longo VD, Seals D, Melov S. PMID: 25056047.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimals
    124. IGF-I regulates the age-dependent signaling peptide humanin. Aging Cell. 2014 Oct; 13(5):958-61. Lee C, Wan J, Miyazaki B, Fang Y, Guevara-Aguirre J, Yen K, Longo V, Bartke A, Cohen P. PMID: 25040290; PMCID: PMC4172517.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimals
    125. Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell. 2014 Jun 05; 14(6):810-23. Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS, Da Sacco S, Mirisola M, Quinn DI, Dorff TB, Kopchick JJ, Longo VD. PMID: 24905167; PMCID: PMC4102383.
      View in: PubMed   Mentions: 244     Fields:    Translation:AnimalsCells
    126. Drug metabolism enzymes in a steatotic model of rat treated with a high fat diet and a low dose of streptozotocin. Food Chem Toxicol. 2014 Aug; 70:54-60. Vornoli A, Pozzo L, Della Croce CM, Gervasi PG, Longo V. PMID: 24815820.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    127. Acetyl-CoA synthetase is a conserved regulator of autophagy and life span. Cell Metab. 2014 Apr 01; 19(4):555-7. Mirzaei H, Longo VD. PMID: 24703691; PMCID: PMC4036695.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    128. Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity. Aging Cell. 2014 Jun; 13(3):457-67. Hu J, Wei M, Mirzaei H, Madia F, Mirisola M, Amparo C, Chagoury S, Kennedy B, Longo VD. PMID: 24649827; PMCID: PMC4032597.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    129. Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab. 2014 Mar 04; 19(3):407-17. Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo VD. PMID: 24606898; PMCID: PMC3988204.
      View in: PubMed   Mentions: 438     Fields:    Translation:HumansAnimalsCells
    130. Serine- and threonine/valine-dependent activation of PDK and Tor orthologs converge on Sch9 to promote aging. PLoS Genet. 2014 Feb; 10(2):e1004113. Mirisola MG, Taormina G, Fabrizio P, Wei M, Hu J, Longo VD. PMID: 24516402; PMCID: PMC3916422.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    131. Fasting: molecular mechanisms and clinical applications. Cell Metab. 2014 Feb 04; 19(2):181-92. Longo VD, Mattson MP. PMID: 24440038; PMCID: PMC3946160.
      View in: PubMed   Mentions: 626     Fields:    Translation:HumansAnimals
    132. Dietary protein restriction inhibits tumor growth in human xenograft models. Oncotarget. 2013 Dec; 4(12):2451-61. Fontana L, Adelaiye RM, Rastelli AL, Miles KM, Ciamporcero E, Longo VD, Nguyen H, Vessella R, Pili R. PMID: 24353195; PMCID: PMC3926840.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    133. SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice. Aging Cell. 2014 Feb; 13(1):193-6. Mercken EM, Hu J, Krzysik-Walker S, Wei M, Li Y, McBurney MW, de Cabo R, Longo VD. PMID: 23941528; PMCID: PMC3907112.
      View in: PubMed   Mentions: 58     Fields:    Translation:Animals
    134. Cloning, expression in E. coli and immunological characterization of Par j 3.0201, a Parietaria pollen profilin variant. Mol Immunol. 2014 Feb; 57(2):220-5. Bonura A, Trapani A, Gulino L, Longo V, Valenta R, Asero R, Colombo P. PMID: 24172226.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    135. Autophagy in blood cancers: biological role and therapeutic implications. Haematologica. 2013 Sep; 98(9):1335-43. Nencioni A, Cea M, Montecucco F, Longo VD, Patrone F, Carella AM, Holyoake TL, Helgason GV. PMID: 24006406; PMCID: PMC3762088.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    136. A radical signal activates the epigenetic regulation of longevity. Cell Metab. 2013 Jun 04; 17(6):812-813. Mirisola MG, Longo VD. PMID: 23747240.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    137. Somatotropic signaling: trade-offs between growth, reproductive development, and longevity. Physiol Rev. 2013 Apr; 93(2):571-98. Bartke A, Sun LY, Longo V. PMID: 23589828; PMCID: PMC3768106.
      View in: PubMed   Mentions: 160     Fields:    Translation:HumansAnimalsCells
    138. Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging Cell. 2013 Apr; 12(2):257-68. Parrella E, Maxim T, Maialetti F, Zhang L, Wan J, Wei M, Cohen P, Fontana L, Longo VD. PMID: 23362919; PMCID: PMC3982836.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    139. Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression. Exp Gerontol. 2013 Oct; 48(10):1120-8. Brandhorst S, Wei M, Hwang S, Morgan TE, Longo VD. PMID: 23454633; PMCID: PMC3762887.
      View in: PubMed   Mentions: 52     Fields:    Translation:Animals
    140. Aging, nutrient signaling, hematopoietic senescence, and cancer. Crit Rev Oncog. 2013; 18(6):559-71. Balasubramanian P, Longo VD. PMID: 24579735; PMCID: PMC3959897.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    141. Assessing chronological aging in bacteria. Methods Mol Biol. 2013; 965:421-37. Gonidakis S, Longo VD. PMID: 23296675; PMCID: PMC4077615.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    142. Assessing chronological aging in Saccharomyces cerevisiae. Methods Mol Biol. 2013; 965:463-72. Hu J, Wei M, Mirisola MG, Longo VD. PMID: 23296677; PMCID: PMC4041521.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    143. GRP78/BiP is a novel downstream target of IGF-1 receptor mediated signaling. J Cell Physiol. 2012 Dec; 227(12):3803-11. Pfaffenbach KT, Pong M, Morgan TE, Wang H, Ott K, Zhou B, Longo VD, Lee AS. PMID: 22422508; PMCID: PMC3421054.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    144. Fasting enhances the response of glioma to chemo- and radiotherapy. PLoS One. 2012; 7(9):e44603. Safdie F, Brandhorst S, Wei M, Wang W, Lee C, Hwang S, Conti PS, Chen TC, Longo VD. PMID: 22984531; PMCID: PMC3439413.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    145. Acetic acid and acidification accelerate chronological and replicative aging in yeast. Cell Cycle. 2012 Oct 01; 11(19):3532-3. Mirisola MG, Longo VD. PMID: 22951542; PMCID: PMC3478300.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    146. Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab. 2012 Jul 03; 16(1):18-31. Longo VD, Shadel GS, Kaeberlein M, Kennedy B. PMID: 22768836; PMCID: PMC3392685.
      View in: PubMed   Mentions: 332     Fields:    Translation:HumansAnimals
    147. Growth factors, nutrient signaling, and cardiovascular aging. Circ Res. 2012 Apr 13; 110(8):1139-50. Fontana L, Vinciguerra M, Longo VD. PMID: 22499903; PMCID: PMC3376758.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    148. Starvation, detoxification, and multidrug resistance in cancer therapy. Drug Resist Updat. 2012 Feb-Apr; 15(1-2):114-22. Lee C, Raffaghello L, Longo VD. PMID: 22391012; PMCID: PMC3573885.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    149. Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci Transl Med. 2012 Mar 07; 4(124):124ra27. Lee C, Raffaghello L, Brandhorst S, Safdie FM, Bianchi G, Martin-Montalvo A, Pistoia V, Wei M, Hwang S, Merlino A, Emionite L, de Cabo R, Longo VD. PMID: 22323820; PMCID: PMC3608686.
      View in: PubMed   Mentions: 329     Fields:    Translation:HumansAnimalsCells
    150. Chronological aging in Saccharomyces cerevisiae. Subcell Biochem. 2012; 57:101-21. Longo VD, Fabrizio P. PMID: 22094419; PMCID: PMC4048025.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    151. Intermittent supplementation with rapamycin as a dietary restriction mimetic. Aging (Albany NY). 2011 Nov; 3(11):1039-40. Longo VD, Fontana L. PMID: 22147496; PMCID: PMC3249447.
      View in: PubMed   Mentions: 26     Fields:    
    152. Studying age-dependent genomic instability using the S. cerevisiae chronological lifespan model. J Vis Exp. 2011 Sep 29; (55). Wei M, Madia F, Longo VD. PMID: 21989366; PMCID: PMC3230202.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    153. Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients. Oncogene. 2011 Jul 28; 30(30):3305-16. Lee C, Longo VD. PMID: 21516129.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansAnimals
    154. Conserved role of Ras-GEFs in promoting aging: from yeast to mice. Aging (Albany NY). 2011 Apr; 3(4):340-3. Mirisola MG, Longo VD. PMID: 21732566; PMCID: PMC3117446.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    155. Metabolic alterations in yeast lacking copper-zinc superoxide dismutase. Free Radic Biol Med. 2011 Jun 01; 50(11):1591-8. Sehati S, Clement MH, Martins J, Xu L, Longo VD, Valentine JS, Gralla EB. PMID: 21397007; PMCID: PMC3090513.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    156. Lifespan extension and paraquat resistance in a ubiquinone-deficient Escherichia coli mutant depend on transcription factors ArcA and TdcA. Aging (Albany NY). 2011 Mar; 3(3):291-303. Gonidakis S, Finkel SE, Longo VD. PMID: 21464517; PMCID: PMC3091522.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    157. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med. 2011 Feb 16; 3(70):70ra13. Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD. PMID: 21325617; PMCID: PMC3357623.
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    158. Expression and characterization of two new alkane-inducible cytochrome P450s from Trichoderma harzianum. Biotechnol Lett. 2011 Jun; 33(6):1201-6. Del Carratore R, Carratore RD, Gervasi PG, Contini MP, Beffy P, Maserti BE, Giovannetti G, Brondolo A, Longo V. PMID: 21327702.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    159. Endosomal protein sorting and autophagy genes contribute to the regulation of yeast life span. Autophagy. 2010 Nov; 6(8):1227-8. Longo VD, Nislow C, Fabrizio P. PMID: 20953148.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    160. Fasting and differential chemotherapy protection in patients. Cell Cycle. 2010 Nov 15; 9(22):4474-6. Raffaghello L, Safdie F, Bianchi G, Dorff T, Fontana L, Longo VD. PMID: 21088487; PMCID: PMC3048045.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimals
    161. E. coli hypoxia-inducible factor ArcA mediates lifespan extension in a lipoic acid synthase mutant by suppressing acetyl-CoA synthetase. Biol Chem. 2010 Oct; 391(10):1139-47. Gonidakis S, Finkel SE, Longo VD. PMID: 20707605; PMCID: PMC4403634.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    162. Genome-wide screen identifies Escherichia coli TCA-cycle-related mutants with extended chronological lifespan dependent on acetate metabolism and the hypoxia-inducible transcription factor ArcA. Aging Cell. 2010 Oct; 9(5):868-81. Gonidakis S, Finkel SE, Longo VD. PMID: 20707865; PMCID: PMC2941539.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    163. Linking Klotho, Nrf2, MAP kinases and aging. Aging (Albany NY). 2010 Oct; 2(10):632-3. Balasubramanian P, Longo VD. PMID: 21076180; PMCID: PMC2993790.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    164. SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci. 2010 Jul 21; 30(29):9695-707. Michán S, Li Y, Chou MM, Parrella E, Ge H, Long JM, Allard JS, Lewis K, Miller M, Xu W, Mervis RF, Chen J, Guerin KI, Smith LE, McBurney MW, Sinclair DA, Baudry M, de Cabo R, Longo VD. PMID: 20660252; PMCID: PMC2921958.
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    165. Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation. PLoS Genet. 2010 Jul 15; 6(7):e1001024. Fabrizio P, Hoon S, Shamalnasab M, Galbani A, Wei M, Giaever G, Nislow C, Longo VD. PMID: 20657825; PMCID: PMC2904796.
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    166. Cell resilience in species life spans: a link to inflammation? Aging Cell. 2010 Aug; 9(4):519-26. Finch CE, Morgan TE, Longo VD, de Magalhaes JP. PMID: 20415721; PMCID: PMC2952360.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    167. Extending healthy life span--from yeast to humans. Science. 2010 Apr 16; 328(5976):321-6. Fontana L, Partridge L, Longo VD. PMID: 20395504; PMCID: PMC3607354.
      View in: PubMed   Mentions: 1522     Fields:    Translation:HumansAnimalsCells
    168. Impact papers on aging in 2009. Aging (Albany NY). 2010 Mar; 2(3):111-21. Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS, Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, Vijg J. PMID: 20351400; PMCID: PMC2871240.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    169. Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Res. 2010 Feb 15; 70(4):1564-72. Lee C, Safdie FM, Raffaghello L, Wei M, Madia F, Parrella E, Hwang D, Cohen P, Bianchi G, Longo VD. PMID: 20145127; PMCID: PMC2836202.
      View in: PubMed   Mentions: 160     Fields:    Translation:AnimalsCells
    170. Molecular cloning and enzymatic characterization of sheep CYP2J. Xenobiotica. 2010 Feb; 40(2):109-18. Messina A, Nencioni S, Gervasi PG, Gotlinger KH, Schwartzman ML, Longo V. PMID: 20021200; PMCID: PMC3067055.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    171. Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends Pharmacol Sci. 2010 Feb; 31(2):89-98. Longo VD, Fontana L. PMID: 20097433; PMCID: PMC2829867.
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    172. Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain. ScientificWorldJournal. 2010 Jan 21; 10:161-77. Parrella E, Longo VD. PMID: 20098959; PMCID: PMC4405166.
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    173. Fasting and cancer treatment in humans: A case series report. Aging (Albany NY). 2009 Dec 31; 1(12):988-1007. Safdie FM, Dorff T, Quinn D, Fontana L, Wei M, Lee C, Cohen P, Longo VD. PMID: 20157582; PMCID: PMC2815756.
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    174. Comparative analyses of time-course gene expression profiles of the long-lived sch9Delta mutant. Nucleic Acids Res. 2010 Jan; 38(1):143-58. Ge H, Wei M, Fabrizio P, Hu J, Cheng C, Longo VD, Li LM. PMID: 19880387; PMCID: PMC2800218.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    175. Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polzeta-dependent mechanism. J Cell Biol. 2009 Aug 24; 186(4):509-23. Madia F, Wei M, Yuan V, Hu J, Gattazzo C, Pham P, Goodman MF, Longo VD. PMID: 19687253; PMCID: PMC2733759.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    176. Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension. PLoS Genet. 2009 May; 5(5):e1000467. Wei M, Fabrizio P, Madia F, Hu J, Ge H, Li LM, Longo VD. PMID: 19424415; PMCID: PMC2669710.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    177. Nerve growth factor and its receptors TrkA and p75 are upregulated in the brain of mdx dystrophic mouse. Neuroscience. 2009 Jul 21; 161(4):1057-66. Nico B, Mangieri D, De Luca A, Corsi P, Benagiano V, Tamma R, Annese T, Longo V, Crivellato E, Ribatti D. PMID: 19376199.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    178. Turning anti-ageing genes against cancer. Nat Rev Mol Cell Biol. 2008 11; 9(11):903-10. Longo VD, Lieber MR, Vijg J. PMID: 18946478.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    179. The chronological life span of Saccharomyces cerevisiae to study mitochondrial dysfunction and disease. Methods. 2008 Dec; 46(4):256-62. Parrella E, Longo VD. PMID: 18930829.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    180. SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab. 2008 Jul; 8(1):38-48. Li Y, Xu W, McBurney MW, Longo VD. PMID: 18590691; PMCID: PMC2822839.
      View in: PubMed   Mentions: 172     Fields:    Translation:AnimalsCells
    181. Linking sirtuins, IGF-I signaling, and starvation. Exp Gerontol. 2009 Jan-Feb; 44(1-2):70-4. Longo VD. PMID: 18638538.
      View in: PubMed   Mentions: 39     Fields:    
    182. Clodronate inhibits angiogenesis in vitro and in vivo. Oncol Rep. 2008 May; 19(5):1109-12. Ribatti D, Maruotti N, Nico B, Longo V, Mangieri D, Vacca A, Cantatore FP. PMID: 18425365.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    183. Chronological aging-induced apoptosis in yeast. Biochim Biophys Acta. 2008 Jul; 1783(7):1280-5. Fabrizio P, Longo VD. PMID: 18445486; PMCID: PMC2536486.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    184. Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proc Natl Acad Sci U S A. 2008 Jun 17; 105(24):8215-20. Raffaghello L, Lee C, Safdie FM, Wei M, Madia F, Bianchi G, Longo VD. PMID: 18378900; PMCID: PMC2448817.
      View in: PubMed   Mentions: 265     Fields:    Translation:HumansAnimalsCells
    185. Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system. J Cell Biol. 2008 Jan 14; 180(1):67-81. Madia F, Gattazzo C, Wei M, Fabrizio P, Burhans WC, Weinberger M, Galbani A, Smith JR, Nguyen C, Huey S, Comai L, Longo VD. PMID: 18195102; PMCID: PMC2213615.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    186. Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. PLoS Genet. 2008 Jan; 4(1):e13. Wei M, Fabrizio P, Hu J, Ge H, Cheng C, Li L, Longo VD. PMID: 18225956; PMCID: PMC2213705.
      View in: PubMed   Mentions: 250     Fields:    Translation:AnimalsCells
    187. Significant and systematic expression differentiation in long-lived yeast strains. PLoS One. 2007 Oct 31; 2(10):e1095. Cheng C, Fabrizio P, Ge H, Wei M, Longo VD, Li LM. PMID: 17971858; PMCID: PMC2039703.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    188. Angiogenesis and mast cells in human breast cancer sentinel lymph nodes with and without micrometastases. Histopathology. 2007 Dec; 51(6):837-42. Ribatti D, Finato N, Crivellato E, Guidolin D, Longo V, Mangieri D, Nico B, Vacca A, Beltrami CA. PMID: 17944928.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    189. Imaging and angiogenesis in hematological malignancies. Leukemia. 2007 Aug; 21(8):1605. Longo V, Vacca A, Ribatti D. PMID: 17637714.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    190. Inference of transcription modification in long-live yeast strains from their expression profiles. BMC Genomics. 2007 Jul 06; 8:219. Cheng C, Fabrizio P, Ge H, Longo VD, Li LM. PMID: 17617911; PMCID: PMC1949827.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    191. Perturbation of rat hepatic metabolising enzymes by folic acid supplementation. Mutat Res. 2008 Jan 01; 637(1-2):16-22. Canistro D, Pozzetti L, Sapone A, Broccoli M, Bonamassa B, Longo V, Lubrano V, Barillari J, Biagi GL, Paolini M. PMID: 17681554.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    192. Perturbation of murine liver cyp-superfamily of isoforms by different combinations of pesticide mixtures. Food Chem Toxicol. 2008 Jan; 46(1):34-42. Canistro D, Pozzetti L, Sapone A, Broccoli M, Affatato AA, Stradiotti A, Longo V, Menichini P, Barale R, Paolini M. PMID: 17686559.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    193. Erythropoietin/erythropoietin receptor system is involved in angiogenesis in human neuroblastoma. Histopathology. 2007 Apr; 50(5):636-41. Ribatti D, Poliani PL, Longo V, Mangieri D, Nico B, Vacca A. PMID: 17394500; PMCID: PMC1890992.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    194. Erythropoietin/erythropoietin-receptor system is involved in angiogenesis in human hepatocellular carcinoma. Histopathology. 2007 Apr; 50(5):591-6. Ribatti D, Marzullo A, Gentile A, Longo V, Nico B, Vacca A, Dammacco F. PMID: 17394495; PMCID: PMC1891001.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    195. In vivo inhibition of human hepatocellular carcinoma related angiogenesis by vinblastine and rapamycin. Histol Histopathol. 2007 03; 22(3):285-9. Ribatti D, Nico B, Mangieri D, Longo V, Sansonno D, Vacca A, Dammacco F. PMID: 17163402.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    196. Cloning, tissue expression, and inducibility of CYP 3A79 from sea bass (Dicentrarchus labrax). J Biochem Mol Toxicol. 2007; 21(1):32-40. Vaccaro E, Salvetti A, Del Carratore R, Nencioni S, Longo V, Gervasi PG. PMID: 17366542.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    197. The chronological life span of Saccharomyces cerevisiae. Methods Mol Biol. 2007; 371:89-95. Fabrizio P, Longo VD. PMID: 17634576.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    198. A simple model system for age-dependent DNA damage and cancer. Mech Ageing Dev. 2007 Jan; 128(1):45-9. Madia F, Gattazzo C, Fabrizio P, Longo VD. PMID: 17118426; PMCID: PMC1847572.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    199. Neridronate inhibits angiogenesis in vitro and in vivo. Clin Rheumatol. 2007 Jul; 26(7):1094-8. Ribatti D, Nico B, Mangieri D, Maruotti N, Longo V, Vacca A, Cantatore FP. PMID: 17106617.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    200. Sirtuins in aging and age-related disease. Cell. 2006 Jul 28; 126(2):257-68. Longo VD, Kennedy BK. PMID: 16873059.
      View in: PubMed   Mentions: 270     Fields:    Translation:HumansAnimalsCells
    201. Aging as a mitochondria-mediated atavistic program: can aging be switched off? Ann N Y Acad Sci. 2005 Dec; 1057:145-64. Skulachev VP, Longo VD. PMID: 16399892.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    202. Sir2 blocks extreme life-span extension. Cell. 2005 Nov 18; 123(4):655-67. Fabrizio P, Gattazzo C, Battistella L, Wei M, Cheng C, McGrew K, Longo VD. PMID: 16286010.
      View in: PubMed   Mentions: 196     Fields:    Translation:AnimalsCells
    203. Programmed and altruistic ageing. Nat Rev Genet. 2005 Nov; 6(11):866-72. Longo VD, Mitteldorf J, Skulachev VP. PMID: 16304601.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    204. Analysis of gene expression profile in yeast aging chronologically. Mech Ageing Dev. 2005 Jan; 126(1):11-6. Fabrizio P, Li L, Longo VD. PMID: 15610757.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    205. Ras: the other pro-aging pathway. Sci Aging Knowledge Environ. 2004 Sep 29; 2004(39):pe36. Longo VD. PMID: 15456908.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    206. Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae. J Cell Biol. 2004 Sep 27; 166(7):1055-67. Fabrizio P, Battistella L, Vardavas R, Gattazzo C, Liou LL, Diaspro A, Dossen JW, Gralla EB, Longo VD. PMID: 15452146; PMCID: PMC2172019.
      View in: PubMed   Mentions: 158     Fields:    Translation:AnimalsCells
    207. Superoxide inhibits 4Fe-4S cluster enzymes involved in amino acid biosynthesis. Cross-compartment protection by CuZn-superoxide dismutase. J Biol Chem. 2004 Jul 30; 279(31):32055-62. Wallace MA, Liou LL, Martins J, Clement MH, Bailey S, Longo VD, Valentine JS, Gralla EB. PMID: 15166213.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    208. Search for methuselah genes heats up. Sci Aging Knowledge Environ. 2004 Feb 11; 2004(6):pe6. Longo VD. PMID: 14960761.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    209. Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae. FEBS Lett. 2004 Jan 16; 557(1-3):136-42. Fabrizio P, Pletcher SD, Minois N, Vaupel JW, Longo VD. PMID: 14741356.
      View in: PubMed   Mentions: 87     Fields:    Translation:Animals
    210. Biodemographic trajectories of age-specific reproliferation from stationary phase in the yeast Saccharomyces cerevisiae seem multiphasic. Mech Ageing Dev. 2003 Dec; 124(10-12):1059-63. Gendron CM, Minois N, Fabrizio P, Longo VD, Pletcher SD, Vaupel JW. PMID: 14659594.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    211. The Ras and Sch9 pathways regulate stress resistance and longevity. Exp Gerontol. 2003 Jul; 38(7):807-11. Longo VD. PMID: 12855292.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    212. The chronological life span of Saccharomyces cerevisiae. Aging Cell. 2003 04; 2(2):73-81. Fabrizio P, Longo VD. PMID: 12882320.
      View in: PubMed   Mentions: 219     Fields:    Translation:HumansAnimals
    213. Evolutionary medicine: from dwarf model systems to healthy centenarians? Science. 2003 Feb 28; 299(5611):1342-6. Longo VD, Finch CE. PMID: 12610293.
      View in: PubMed   Mentions: 218     Fields:    Translation:HumansAnimalsCells
    214. SOD2 functions downstream of Sch9 to extend longevity in yeast. Genetics. 2003 Jan; 163(1):35-46. Fabrizio P, Liou LL, Moy VN, Diaspro A, Valentine JS, Gralla EB, Longo VD. PMID: 12586694; PMCID: PMC1462415.
      View in: PubMed   Mentions: 171     Fields:    Translation:Animals
    215. 4-Biphenylaldehyde and 9-anthraldehyde: two fluorescent substrates for determining P450 enzyme activities in rat and human. Xenobiotica. 2003 Jan; 33(1):1-11. Marini S, Grasso E, Longo V, Puccini P, Riccardi B, Gervasi PG. PMID: 12519690.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    216. Genetics of aging and diseases: from rare mutations and model systems to disease prevention. Arch Neurol. 2002 Nov; 59(11):1706-8. Longo VD, Finch CE. PMID: 12433254.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    217. Oxygen? No thanks, I'm on a diet. Sci Aging Knowledge Environ. 2002 Jun 19; 2002(24):pe10. Longo VD. PMID: 14602992.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    218. Regulation of longevity and stress resistance: a molecular strategy conserved from yeast to humans? Cell Mol Life Sci. 2002 Jun; 59(6):903-8. Longo VD, Fabrizio P. PMID: 12169020; PMCID: PMC11337509.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimals
    219. Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia. J Neurosci. 2002 May 01; 22(9):3484-92. Xie Z, Wei M, Morgan TE, Fabrizio P, Han D, Finch CE, Longo VD. PMID: 11978825; PMCID: PMC6758387.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    220. Selective inactivation of rat and bovine olfactory cytochrome P450 by three haloethanes. Toxicol Lett. 2001 Oct 15; 124(1-3):83-90. Marini S, Longo V, Zaccaro C, De Matteis F, Gervasi PG. PMID: 11684360.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    221. Regulation of longevity and stress resistance by Sch9 in yeast. Science. 2001 Apr 13; 292(5515):288-90. Fabrizio P, Pozza F, Pletcher SD, Gendron CM, Longo VD. PMID: 11292860.
      View in: PubMed   Mentions: 425     Fields:    Translation:AnimalsCells
    222. Reversible inactivation of superoxide-sensitive aconitase in Abeta1-42-treated neuronal cell lines. J Neurochem. 2000 Nov; 75(5):1977-85. Longo VD, Viola KL, Klein WL, Finch CE. PMID: 11032887.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    223. Cytochrome P450-dependent monooxygenase activities and their inducibility by classic P450 inducers in the liver, kidney, and nasal mucosa of male adult ring-necked pheasants. Toxicol Appl Pharmacol. 2000 Sep 15; 167(3):237-45. Giorgi M, Marini S, Longo V, Mazzaccaro A, Amato G, Gervasi PG. PMID: 10986015.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    224. Stabilization of cytochrome P4502E1 protein by ethanol in primary hamster hepatocyte cultures. Toxicol In Vitro. 2000 Feb; 14(1):69-77. Zanelli U, Longo V, Paolicchi A, Gervasi PG. PMID: 10699363.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    225. Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells. Neurobiol Aging. 1999 Sep-Oct; 20(5):479-86. Longo VD. PMID: 10638521.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    226. Mitochondrial superoxide decreases yeast survival in stationary phase. Arch Biochem Biophys. 1999 May 01; 365(1):131-42. Longo VD, Liou LL, Valentine JS, Gralla EB. PMID: 10222047.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    227. Biodemographic trajectories of longevity. Science. 1998 May 08; 280(5365):855-60. Vaupel JW, Carey JR, Christensen K, Johnson TE, Yashin AI, Holm NV, Iachine IA, Kannisto V, Khazaeli AA, Liedo P, Longo VD, Zeng Y, Manton KG, Curtsinger JW. PMID: 9599158.
      View in: PubMed   Mentions: 247     Fields:    Translation:HumansAnimals
    228. Chlorzoxazone 6-hydroxylase and p-nitrophenol hydroxylase as the most suitable activities for assaying cytochrome P450 2E1 in cynomolgus monkey liver. Drug Metab Dispos. 1998 May; 26(5):483-9. Amato G, Longo V, Mazzaccaro A, Gervasi PG. PMID: 9571230.
      View in: PubMed   Mentions: 4     Fields:    
    229. Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast. J Cell Biol. 1997 Jun 30; 137(7):1581-8. Longo VD, Ellerby LM, Bredesen DE, Valentine JS, Gralla EB. PMID: 9199172; PMCID: PMC2137818.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimals
    230. Purification and characterization of three constitutive cytochrome P-450 isoforms from bovine olfactory epithelium. Biochem J. 1997 Apr 01; 323 ( Pt 1):65-70. Longo V, Amato G, Santucci A, Gervasi PG. PMID: 9173903; PMCID: PMC1218316.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    231. Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo. J Biol Chem. 1996 May 24; 271(21):12275-80. Longo VD, Gralla EB, Valentine JS. PMID: 8647826.
      View in: PubMed   Mentions: 186     Fields:    Translation:AnimalsCells
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