Simon Melov

Title(s)Professor
SchoolSchool of Gerontology
Address3715 McClintock Avenue, GER 102
University Park Campus
Los Angeles CA 90089
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Dietary restriction and the transcription factor clock delay eye aging to extend lifespan in Drosophila Melanogaster. Nat Commun. 2022 06 07; 13(1):3156. Hodge BA, Meyerhof GT, Katewa SD, Lian T, Lau C, Bar S, Leung NY, Li M, Li-Kroeger D, Melov S, Schilling B, Montell C, Kapahi P. PMID: 35672419; PMCID: PMC9174495.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types. iScience. 2022 Feb 18; 25(2):103848. Limbad C, Doi R, McGirr J, Ciotlos S, Perez K, Clayton ZS, Daya R, Seals DR, Campisi J, Melov S. PMID: 35198901; PMCID: PMC8851282.
      View in: PubMed   Mentions: 2  
    3. Accelerated aging of the brain transcriptome by the common chemotherapeutic doxorubicin. Exp Gerontol. 2021 09; 152:111451. Cavalier AN, Clayton ZS, Hutton DA, Wahl D, Lark DS, Reisz JA, Melov S, Campisi J, Seals DR, LaRocca TJ. PMID: 34147619; PMCID: PMC8319121.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging. Am J Physiol Heart Circ Physiol. 2021 07 01; 321(1):H185-H196. Clayton ZS, Hutton DA, Brunt VE, VanDongen NS, Ziemba BP, Casso AG, Greenberg NT, Mercer AN, Rossman MJ, Campisi J, Melov S, Seals DR. PMID: 34114892; PMCID: PMC8321807.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    5. Tumor Necrosis Factor Alpha-Mediated Inflammation and Remodeling of the Extracellular Matrix Underlies Aortic Stiffening Induced by the Common Chemotherapeutic Agent Doxorubicin. Hypertension. 2021 05 05; 77(5):1581-1590. Clayton ZS, Brunt VE, Hutton DA, Casso AG, Ziemba BP, Melov S, Campisi J, Seals DR. PMID: 33719511; PMCID: PMC8035245.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    6. Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs. JBMR Plus. 2021 Mar; 5(3):e10466. Evans DS, O'Leary MN, Murphy R, Schmidt M, Koenig K, Presley M, Garrett B, Kim HN, Han L, Academia EC, Laye MJ, Edgar D, Zambataro CA, Barhydt T, Dewey CM, Mayfield J, Wilson J, Alavez S, Lucanic M, Kennedy BK, Almeida M, Andersen JK, Kapahi P, Lithgow GJ, Melov S. PMID: 33778327; PMCID: PMC7990142.
      View in: PubMed   Mentions: 2  
    7. Superoxide produced by mitochondrial site IQ inactivates cardiac succinate dehydrogenase and induces hepatic steatosis in Sod2 knockout mice. Free Radic Biol Med. 2021 02 20; 164:223-232. Wong HS, Mezera V, Dighe P, Melov S, Gerencser AA, Sweis RF, Pliushchev M, Wang Z, Esbenshade T, McKibben B, Riedmaier S, Brand MD. PMID: 33421588.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    8. From discoveries in ageing research to therapeutics for healthy ageing. Nature. 2019 07; 571(7764):183-192. Campisi J, Kapahi P, Lithgow GJ, Melov S, Newman JC, Verdin E. PMID: 31292558; PMCID: PMC7205183.
      View in: PubMed   Mentions: 198     Fields:    Translation:HumansCells
    9. mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance. Cell Stem Cell. 2017 Dec 07; 21(6):806-818.e5. Haller S, Kapuria S, Riley RR, O'Leary MN, Schreiber KH, Andersen JK, Melov S, Que J, Rando TA, Rock J, Kennedy BK, Rodgers JT, Jasper H. PMID: 29220665; PMCID: PMC5823264.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    10. Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nat Commun. 2017 11 07; 8(1):1414. Zillikens MC, Demissie S, Hsu YH, Yerges-Armstrong LM, Chou WC, Stolk L, Livshits G, Broer L, Johnson T, Koller DL, Kutalik Z, Luan J, Malkin I, Ried JS, Smith AV, Thorleifsson G, Vandenput L, Hua Zhao J, Zhang W, Aghdassi A, Åkesson K, Amin N, Baier LJ, Barroso I, Bennett DA, Bertram L, Biffar R, Bochud M, Boehnke M, Borecki IB, Buchman AS, Byberg L, Campbell H, Campos Obanda N, Cauley JA, Cawthon PM, Cederberg H, Chen Z, Cho NH, Jin Choi H, Claussnitzer M, Collins F, Cummings SR, De Jager PL, Demuth I, Dhonukshe-Rutten RAM, Diatchenko L, Eiriksdottir G, Enneman AW, Erdos M, Eriksson JG, Eriksson J, Estrada K, Evans DS, Feitosa MF, Fu M, Garcia M, Gieger C, Girke T, Glazer NL, Grallert H, Grewal J, Han BG, Hanson RL, Hayward C, Hofman A, Hoffman EP, Homuth G, Hsueh WC, Hubal MJ, Hubbard A, Huffman KM, Husted LB, Illig T, Ingelsson E, Ittermann T, Jansson JO, Jordan JM, Jula A, Karlsson M, Khaw KT, Kilpeläinen TO, Klopp N, Kloth JSL, Koistinen HA, Kraus WE, Kritchevsky S, Kuulasmaa T, Kuusisto J, Laakso M, Lahti J, Lang T, Langdahl BL, Launer LJ, Lee JY, Lerch MM, Lewis JR, Lind L, Lindgren C, Liu Y, Liu T, Liu Y, Ljunggren Ö, Lorentzon M, Luben RN, Maixner W, McGuigan FE, Medina-Gomez C, Meitinger T, Melhus H, Mellström D, Melov S, Michaëlsson K, Mitchell BD, Morris AP, Mosekilde L, Newman A, Nielson CM, O'Connell JR, Oostra BA, Orwoll ES, Palotie A, Parker SCJ, Peacock M, Perola M, Peters A, Polasek O, Prince RL, Räikkönen K, Ralston SH, Ripatti S, Robbins JA, Rotter JI, Rudan I, Salomaa V, Satterfield S, Schadt EE, Schipf S, Scott L, Sehmi J, Shen J, Soo Shin C, Sigurdsson G, Smith S, Soranzo N, Stancáková A, Steinhagen-Thiessen E, Streeten EA, Styrkarsdottir U, Swart KMA, Tan ST, Tarnopolsky MA, Thompson P, Thomson CA, Thorsteinsdottir U, Tikkanen E, Tranah GJ, Tuomilehto J, van Schoor NM, Verma A, Vollenweider P, Völzke H, Wactawski-Wende J, Walker M, Weedon MN, Welch R, Wichmann HE, Widen E, Williams FMK, Wilson JF, Wright NC, Xie W, Yu L, Zhou Y, Chambers JC, Döring A, van Duijn CM, Econs MJ, Gudnason V, Kooner JS, Psaty BM, Spector TD, Stefansson K, Rivadeneira F, Uitterlinden AG, Wareham NJ, Ossowski V, Waterworth D, Loos RJF, Karasik D, Harris TB, Ohlsson C, Kiel DP. PMID: 29116125; PMCID: PMC5676783.
      View in: PubMed   Mentions: 2     Fields:    
    11. Unmasking Transcriptional Heterogeneity in Senescent Cells. Curr Biol. 2017 Sep 11; 27(17):2652-2660.e4. Hernandez-Segura A, de Jong TV, Melov S, Guryev V, Campisi J, Demaria M. PMID: 28844647; PMCID: PMC5788810.
      View in: PubMed   Mentions: 211     Fields:    Translation:HumansAnimalsCells
    12. Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nat Commun. 2017 07 19; 8(1):80. Zillikens MC, Demissie S, Hsu YH, Yerges-Armstrong LM, Chou WC, Stolk L, Livshits G, Broer L, Johnson T, Koller DL, Kutalik Z, Luan J, Malkin I, Ried JS, Smith AV, Thorleifsson G, Vandenput L, Hua Zhao J, Zhang W, Aghdassi A, Åkesson K, Amin N, Baier LJ, Barroso I, Bennett DA, Bertram L, Biffar R, Bochud M, Boehnke M, Borecki IB, Buchman AS, Byberg L, Campbell H, Campos Obanda N, Cauley JA, Cawthon PM, Cederberg H, Chen Z, Cho NH, Jin Choi H, Claussnitzer M, Collins F, Cummings SR, De Jager PL, Demuth I, Dhonukshe-Rutten RAM, Diatchenko L, Eiriksdottir G, Enneman AW, Erdos M, Eriksson JG, Eriksson J, Estrada K, Evans DS, Feitosa MF, Fu M, Garcia M, Gieger C, Girke T, Glazer NL, Grallert H, Grewal J, Han BG, Hanson RL, Hayward C, Hofman A, Hoffman EP, Homuth G, Hsueh WC, Hubal MJ, Hubbard A, Huffman KM, Husted LB, Illig T, Ingelsson E, Ittermann T, Jansson JO, Jordan JM, Jula A, Karlsson M, Khaw KT, Kilpeläinen TO, Klopp N, Kloth JSL, Koistinen HA, Kraus WE, Kritchevsky S, Kuulasmaa T, Kuusisto J, Laakso M, Lahti J, Lang T, Langdahl BL, Launer LJ, Lee JY, Lerch MM, Lewis JR, Lind L, Lindgren C, Liu Y, Liu T, Liu Y, Ljunggren Ö, Lorentzon M, Luben RN, Maixner W, McGuigan FE, Medina-Gomez C, Meitinger T, Melhus H, Mellström D, Melov S, Michaëlsson K, Mitchell BD, Morris AP, Mosekilde L, Newman A, Nielson CM, O'Connell JR, Oostra BA, Orwoll ES, Palotie A, Parker SCJ, Peacock M, Perola M, Peters A, Polasek O, Prince RL, Räikkönen K, Ralston SH, Ripatti S, Robbins JA, Rotter JI, Rudan I, Salomaa V, Satterfield S, Schadt EE, Schipf S, Scott L, Sehmi J, Shen J, Soo Shin C, Sigurdsson G, Smith S, Soranzo N, Stancáková A, Steinhagen-Thiessen E, Streeten EA, Styrkarsdottir U, Swart KMA, Tan ST, Tarnopolsky MA, Thompson P, Thomson CA, Thorsteinsdottir U, Tikkanen E, Tranah GJ, Tuomilehto J, van Schoor NM, Verma A, Vollenweider P, Völzke H, Wactawski-Wende J, Walker M, Weedon MN, Welch R, Wichmann HE, Widen E, Williams FMK, Wilson JF, Wright NC, Xie W, Yu L, Zhou Y, Chambers JC, Döring A, van Duijn CM, Econs MJ, Gudnason V, Kooner JS, Psaty BM, Spector TD, Stefansson K, Rivadeneira F, Uitterlinden AG, Wareham NJ, Ossowski V, Waterworth D, Loos RJF, Karasik D, Harris TB, Ohlsson C, Kiel DP. PMID: 28724990; PMCID: PMC5517526.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    13. Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence. Aging Cell. 2017 10; 16(5):1043-1050. Wiley CD, Flynn JM, Morrissey C, Lebofsky R, Shuga J, Dong X, Unger MA, Vijg J, Melov S, Campisi J. PMID: 28699239; PMCID: PMC5595671.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    14. Response by Simpson et al to Letter Regarding Article, "Adrenergic Receptors in Individual Ventricular Myocytes: the Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent". Circ Res. 2017 06 09; 120(12):e56-e57. Simpson PC, Myagmar BE, Swigart PM, Melov S, Baker AJ. PMID: 28596177; PMCID: PMC5501172.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    15. Long-term calorie restriction in humans is not associated with indices of delayed immunologic aging: A descriptive study. Nutr Healthy Aging. 2017 Mar 31; 4(2):147-156. Tomiyama AJ, Milush JM, Lin J, Flynn JM, Kapahi P, Verdin E, Sinclair E, Melov S, Epel ES. PMID: 28447069; PMCID: PMC5389018.
      View in: PubMed   Mentions: 6  
    16. Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent. Circ Res. 2017 Mar 31; 120(7):1103-1115. Myagmar BE, Flynn JM, Cowley PM, Swigart PM, Montgomery MD, Thai K, Nair D, Gupta R, Deng DX, Hosoda C, Melov S, Baker AJ, Simpson PC. PMID: 28219977; PMCID: PMC5376223.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    17. Expression patterns of cardiac aging in Drosophila. Aging Cell. 2017 Feb; 16(1):82-92. Cannon L, Zambon AC, Cammarato A, Zhang Z, Vogler G, Munoz M, Taylor E, Cartry J, Bernstein SI, Melov S, Bodmer R. PMID: 28090760; PMCID: PMC5242310.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    18. Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing. Cell Rep. 2017 01 10; 18(2):545-556. Zhang Y, O'Leary MN, Peri S, Wang M, Zha J, Melov S, Kappes DJ, Feng Q, Rhodes J, Amieux PS, Morris DR, Kennedy BK, Wiest DL. PMID: 28076796; PMCID: PMC5234864.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    19. Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. Cancer Discov. 2017 02; 7(2):165-176. Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C, Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H, Campisi J. PMID: 27979832; PMCID: PMC5296251.
      View in: PubMed   Mentions: 350     Fields:    Translation:HumansAnimals
    20. Uncovering the Dark Energy of Aging. Cell Syst. 2016 10 26; 3(4):328-330. Melov S. PMID: 27788357.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    21. Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1. Cell Rep. 2016 10 25; 17(5):1227-1237. Mark KA, Dumas KJ, Bhaumik D, Schilling B, Davis S, Oron TR, Sorensen DJ, Lucanic M, Brem RB, Melov S, Ramanathan A, Gibson BW, Lithgow GJ. PMID: 27783938; PMCID: PMC5689451.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    22. Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury. Cell Metab. 2016 10 11; 24(4):582-592. Brand MD, Goncalves RL, Orr AL, Vargas L, Gerencser AA, Borch Jensen M, Wang YT, Melov S, Turk CN, Matzen JT, Dardov VJ, Petrassi HM, Meeusen SL, Perevoshchikova IV, Jasper H, Brookes PS, Ainscow EK. PMID: 27667666; PMCID: PMC5061631.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    23. Geroscience approaches to increase healthspan and slow aging. F1000Res. 2016; 5. Melov S. PMID: 27158475; PMCID: PMC4856109.
      View in: PubMed   Mentions: 7     Fields:    
    24. Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington's Disease Neural Stem Cells. Stem Cell Reports. 2015 Dec 08; 5(6):1023-1038. Ring KL, An MC, Zhang N, O'Brien RN, Ramos EM, Gao F, Atwood R, Bailus BJ, Melov S, Mooney SD, Coppola G, Ellerby LM. PMID: 26651603; PMCID: PMC4682390.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    25. Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10407-12. Velarde MC, Demaria M, Melov S, Campisi J. PMID: 26240345; PMCID: PMC4547253.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    26. Translational geroscience: emphasizing function to achieve optimal longevity. Aging (Albany NY). 2014 Sep; 6(9):718-30. Seals DR, Melov S. PMID: 25324468; PMCID: PMC4221919.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    27. Medical research: treat ageing. Nature. 2014 Jul 24; 511(7510):405-7. Fontana L, Kennedy BK, Longo VD, Seals D, Melov S. PMID: 25056047.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimals
    28. Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. Cell Rep. 2013 Dec 26; 5(6):1600-10. Chen D, Li PW, Goldstein BA, Cai W, Thomas EL, Chen F, Hubbard AE, Melov S, Kapahi P. PMID: 24332851; PMCID: PMC3904953.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    29. Genome-wide DNA methylation changes with age in disease-free human skeletal muscle. Aging Cell. 2014 Apr; 13(2):360-6. Zykovich A, Hubbard A, Flynn JM, Tarnopolsky M, Fraga MF, Kerksick C, Ogborn D, MacNeil L, Mooney SD, Melov S. PMID: 24304487; PMCID: PMC3954952.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    30. Late-life rapamycin treatment reverses age-related heart dysfunction. Aging Cell. 2013 Oct; 12(5):851-62. Flynn JM, O'Leary MN, Zambataro CA, Academia EC, Presley MP, Garrett BJ, Zykovich A, Mooney SD, Strong R, Rosen CJ, Kapahi P, Nelson MD, Kennedy BK, Melov S. PMID: 23734717; PMCID: PMC4098908.
      View in: PubMed   Mentions: 143     Fields:    Translation:AnimalsCells
    31. Age-related micro-RNA abundance in individual C. elegans. Aging (Albany NY). 2013 Jun; 5(6):394-411. Lucanic M, Graham J, Scott G, Bhaumik D, Benz CC, Hubbard A, Lithgow GJ, Melov S. PMID: 23793570; PMCID: PMC3824409.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    32. SOD2 in mitochondrial dysfunction and neurodegeneration. Free Radic Biol Med. 2013 Sep; 62:4-12. Flynn JM, Melov S. PMID: 23727323; PMCID: PMC3811078.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansCells
    33. Single cell gene expression profiling of cortical osteoblast lineage cells. Bone. 2013 Mar; 53(1):174-81. Flynn JM, Spusta SC, Rosen CJ, Melov S. PMID: 23238121; PMCID: PMC3589579.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    34. No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease. J Neurosci. 2012 Nov 21; 32(47):16775-84. Choi SW, Gerencser AA, Ng R, Flynn JM, Melov S, Danielson SR, Gibson BW, Nicholls DG, Bredesen DE, Brand MD. PMID: 23175831; PMCID: PMC3736741.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    35. Proteogenomics of synaptosomal mitochondrial oxidative stress. Free Radic Biol Med. 2012 Sep 01; 53(5):1048-60. Flynn JM, Czerwieniec GA, Choi SW, Day NU, Gibson BW, Hubbard A, Melov S. PMID: 22796328; PMCID: PMC3436120.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    36. Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. Cell Metab. 2012 Jul 03; 16(1):97-103. Katewa SD, Demontis F, Kolipinski M, Hubbard A, Gill MS, Perrimon N, Melov S, Kapahi P. PMID: 22768842; PMCID: PMC3400463.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    37. Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells. Cell Stem Cell. 2012 Aug 03; 11(2):253-63. An MC, Zhang N, Scott G, Montoro D, Wittkop T, Mooney S, Melov S, Ellerby LM. PMID: 22748967; PMCID: PMC3608272.
      View in: PubMed   Mentions: 174     Fields:    Translation:HumansCells
    38. Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease. Free Radic Biol Med. 2012 Aug 15; 53(4):993-1003. Siddiqui A, Chinta SJ, Mallajosyula JK, Rajagopolan S, Hanson I, Rane A, Melov S, Andersen JK. PMID: 22705949; PMCID: PMC3418424.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    39. Premature expression of a muscle fibrosis axis in chronic HIV infection. Skelet Muscle. 2012 Jun 07; 2(1):10. Kusko RL, Banerjee C, Long KK, Darcy A, Otis J, Sebastiani P, Melov S, Tarnopolsky M, Bhasin S, Montano M. PMID: 22676806; PMCID: PMC3407733.
      View in: PubMed   Mentions: 16     Fields:    
    40. cep-1/p53-dependent dysplastic pathology of the aging C. elegans gonad. Aging (Albany NY). 2012 Apr; 4(4):256-69. McGee MD, Day N, Graham J, Melov S. PMID: 22562940; PMCID: PMC3378273.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    41. Massage therapy attenuates inflammatory signaling after exercise-induced muscle damage. Sci Transl Med. 2012 Feb 01; 4(119):119ra13. Crane JD, Ogborn DI, Cupido C, Melov S, Hubbard A, Bourgeois JM, Tarnopolsky MA. PMID: 22301554.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCells
    42. Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY). 2012 Jan; 4(1):3-12. Velarde MC, Flynn JM, Day NU, Melov S, Campisi J. PMID: 22278880; PMCID: PMC3292901.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    43. Single cell transcriptional profiling of adult mouse cardiomyocytes. J Vis Exp. 2011 Dec 28; (58):e3302. Flynn JM, Santana LF, Melov S. PMID: 22231655; PMCID: PMC3369660.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    44. Human embryonic stem cells express elevated levels of multiple pro-apoptotic BCL-2 family members. PLoS One. 2011; 6(12):e28530. Madden DT, Davila-Kruger D, Melov S, Bredesen DE. PMID: 22174832; PMCID: PMC3235131.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    45. On the programmed/non-programmed nature of ageing within the life history. Curr Biol. 2011 Sep 27; 21(18):R701-7. Kirkwood TB, Melov S. PMID: 21959160.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimals
    46. Cellular senescence: a link between cancer and age-related degenerative disease? Semin Cancer Biol. 2011 Dec; 21(6):354-9. Campisi J, Andersen JK, Kapahi P, Melov S. PMID: 21925603; PMCID: PMC3230665.
      View in: PubMed   Mentions: 172     Fields:    Translation:Humans
    47. Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans. Cell Metab. 2011 Jul 06; 14(1):55-66. Rogers AN, Chen D, McColl G, Czerwieniec G, Felkey K, Gibson BW, Hubbard A, Melov S, Lithgow GJ, Kapahi P. PMID: 21723504; PMCID: PMC3220185.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    48. Loss of intestinal nuclei and intestinal integrity in aging C. elegans. Aging Cell. 2011 Aug; 10(4):699-710. McGee MD, Weber D, Day N, Vitelli C, Crippen D, Herndon LA, Hall DH, Melov S. PMID: 21501374; PMCID: PMC3135675.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    49. Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice. Proc Natl Acad Sci U S A. 2011 03 08; 108(10):4135-40. Safdar A, Bourgeois JM, Ogborn DI, Little JP, Hettinga BP, Akhtar M, Thompson JE, Melov S, Mocellin NJ, Kujoth GC, Prolla TA, Tarnopolsky MA. PMID: 21368114; PMCID: PMC3053975.
      View in: PubMed   Mentions: 147     Fields:    Translation:AnimalsCells
    50. The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation. Exp Gerontol. 2011 Jun; 46(6):441-52. Powolny AA, Singh SV, Melov S, Hubbard A, Fisher AL. PMID: 21296648; PMCID: PMC3104016.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    51. Impaired spare respiratory capacity in cortical synaptosomes from Sod2 null mice. Free Radic Biol Med. 2011 Apr 01; 50(7):866-73. Flynn JM, Choi SW, Day NU, Gerencser AA, Hubbard A, Melov S. PMID: 21215798; PMCID: PMC3061438.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    52. Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans. Cell Metab. 2010 Sep 08; 12(3):260-72. McColl G, Rogers AN, Alavez S, Hubbard AE, Melov S, Link CD, Bush AI, Kapahi P, Lithgow GJ. PMID: 20816092; PMCID: PMC2945254.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    53. Eccentric exercise activates novel transcriptional regulation of hypertrophic signaling pathways not affected by hormone changes. PLoS One. 2010 May 18; 5(5):e10695. MacNeil LG, Melov S, Hubbard AE, Baker SK, Tarnopolsky MA. PMID: 20502695; PMCID: PMC2872670.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    54. Limb immobilization induces a coordinate down-regulation of mitochondrial and other metabolic pathways in men and women. PLoS One. 2009 Aug 05; 4(8):e6518. Abadi A, Glover EI, Isfort RJ, Raha S, Safdar A, Yasuda N, Kaczor JJ, Melov S, Hubbard A, Qu X, Phillips SM, Tarnopolsky M. PMID: 19654872; PMCID: PMC2716517.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    55. A human protein interaction network shows conservation of aging processes between human and invertebrate species. PLoS Genet. 2009 Mar; 5(3):e1000414. Bell R, Hubbard A, Chettier R, Chen D, Miller JP, Kapahi P, Tarnopolsky M, Sahasrabuhde S, Melov S, Hughes RE. PMID: 19293945; PMCID: PMC2657003.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    56. Age-related behaviors have distinct transcriptional profiles in Caenorhabditis elegans. Aging Cell. 2008 Dec; 7(6):850-65. Golden TR, Hubbard A, Dando C, Herren MA, Melov S. PMID: 18778409; PMCID: PMC2613281.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    57. Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas. Free Radic Biol Med. 2009 Feb 01; 46(3):387-96. Samper E, Morgado L, Estrada JC, Bernad A, Hubbard A, Cadenas S, Melov S. PMID: 19038329; PMCID: PMC2665299.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    58. Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans. J Biol Chem. 2008 Jan 04; 283(1):350-357. McColl G, Killilea DW, Hubbard AE, Vantipalli MC, Melov S, Lithgow GJ. PMID: 17959600; PMCID: PMC2739662.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    59. Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation. Physiol Genomics. 2008 Jan 17; 32(2):219-28. Safdar A, Yardley NJ, Snow R, Melov S, Tarnopolsky MA. PMID: 17957000.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    60. Mitochondrial oxidative stress causes hyperphosphorylation of tau. PLoS One. 2007 Jun 20; 2(6):e536. Melov S, Adlard PA, Morten K, Johnson F, Golden TR, Hinerfeld D, Schilling B, Mavros C, Masters CL, Volitakis I, Li QX, Laughton K, Hubbard A, Cherny RA, Gibson B, Bush AI. PMID: 17579710; PMCID: PMC1888726.
      View in: PubMed   Mentions: 144     Fields:    Translation:AnimalsCells
    61. Resistance exercise reverses aging in human skeletal muscle. PLoS One. 2007 May 23; 2(5):e465. Melov S, Tarnopolsky MA, Beckman K, Felkey K, Hubbard A. PMID: 17520024; PMCID: PMC1866181.
      View in: PubMed   Mentions: 118     Fields:    Translation:Humans
    62. Gene expression changes associated with aging in C. elegans. WormBook. 2007 Feb 12; 1-12. Golden TR, Melov S. PMID: 18050504; PMCID: PMC4781587.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    63. Dramatic age-related changes in nuclear and genome copy number in the nematode Caenorhabditis elegans. Aging Cell. 2007 Apr; 6(2):179-88. Golden TR, Beckman KB, Lee AH, Dudek N, Hubbard A, Samper E, Melov S. PMID: 17286610; PMCID: PMC2049047.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    64. Nigrostriatal dopaminergic neurodegeneration in the weaver mouse is mediated via neuroinflammation and alleviated by minocycline administration. J Neurosci. 2006 Nov 08; 26(45):11644-51. Peng J, Xie L, Stevenson FF, Melov S, Di Monte DA, Andersen JK. PMID: 17093086; PMCID: PMC6674792.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    65. Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice. PLoS Genet. 2006 Jan; 2(1):e10. Xia XG, Zhou H, Samper E, Melov S, Xu Z. PMID: 16450009; PMCID: PMC1358942.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    66. Mitochondrial reactive oxygen species in mice lacking superoxide dismutase 2: attenuation via antioxidant treatment. J Biol Chem. 2006 Feb 10; 281(6):3354-9. Morten KJ, Ackrell BA, Melov S. PMID: 16326710.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    67. Science fact and the SENS agenda. What can we reasonably expect from ageing research? EMBO Rep. 2005 Nov; 6(11):1006-8. Warner H, Anderson J, Austad S, Bergamini E, Bredesen D, Butler R, Carnes BA, Clark BF, Cristofalo V, Faulkner J, Guarente L, Harrison DE, Kirkwood T, Lithgow G, Martin G, Masoro E, Melov S, Miller RA, Olshansky SJ, Partridge L, Pereira-Smith O, Perls T, Richardson A, Smith J, von Zglinicki T, Wang E, Wei JY, Williams TF. PMID: 16264422; PMCID: PMC1371037.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    68. Biomarker discovery and analysis platform: application to Alzheimer's disease. Biotechniques. 2005 Oct; 39(4):606-7. Kuzdzal S, Lopez M, Mikulskis A, Golenko E, DiCesare J, Denoyer E, Patton W, Ediger R, Sapp L, Ziegert T, Ackloo S, Wall MR, Mannion DP, della Cioppa G, Wolfe G, Bennett D, Melov S. PMID: 16235574.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    69. Alzheimer disease beta-amyloid activity mimics cholesterol oxidase. J Clin Invest. 2005 Sep; 115(9):2556-63. Puglielli L, Friedlich AL, Setchell KD, Nagano S, Opazo C, Cherny RA, Barnham KJ, Wade JD, Melov S, Kovacs DM, Bush AI. PMID: 16127459; PMCID: PMC1190368.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    70. Hyperplasia, reduced E-cadherin expression, and developmental arrest in mammary glands oxidatively stressed by loss of mitochondrial superoxide dismutase. Breast. 2005 Aug; 14(4):256-63. Parmar H, Melov S, Samper E, Ljung BM, Cunha GR, Benz CC. PMID: 16085231.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    71. Pharmacogenomic profiling of an oxidative stress-mediated spongiform encephalopathy. Free Radic Biol Med. 2005 Jul 15; 39(2):152-63. Golden TR, Hubbard A, Morten KJ, Hinerfeld D, Melov S. PMID: 15964507.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    72. Mice transgenic for Alzheimer disease beta-amyloid develop lens cataracts that are rescued by antioxidant treatment. Free Radic Biol Med. 2005 Jan 15; 38(2):258-61. Melov S, Wolf N, Strozyk D, Doctrow SR, Bush AI. PMID: 15607908.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    73. Microarrays as a tool to investigate the biology of aging: a retrospective and a look to the future. Sci Aging Knowledge Environ. 2004 Oct 20; 2004(42):re7. Melov S, Hubbard A. PMID: 15498758.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    74. Modeling mitochondrial function in aging neurons. Trends Neurosci. 2004 Oct; 27(10):601-6. Melov S. PMID: 15374671.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    75. Gene expression profiling in mitochondrial disease: assessment of microarray accuracy by high-throughput Q-PCR. Mitochondrion. 2004 Sep; 4(5-6):453-70. Beckman KB, Lee KY, Golden T, Melov S. PMID: 16120406.
      View in: PubMed   Mentions: 12     Fields:    
    76. Microscale fractionation facilitates detection of differentially expressed proteins in Alzheimer's disease brain samples. Electrophoresis. 2004 Aug; 25(15):2557-63. Lopez MF, Mikulskis A, Golenko E, Melov S, Bennett D, Cherkasskiy A, Kuzdzal S, Kramer S, Sissors D. PMID: 15300776.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    77. Microarray analysis of gene expression with age in individual nematodes. Aging Cell. 2004 Jun; 3(3):111-24. Golden TR, Melov S. PMID: 15153179.
      View in: PubMed   Mentions: 45     Fields:    Translation:Animals
    78. Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice. J Neurochem. 2004 Feb; 88(3):657-67. Hinerfeld D, Traini MD, Weinberger RP, Cochran B, Doctrow SR, Harry J, Melov S. PMID: 14720215.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    79. Proteomic analysis of mitochondrial proteins. Int Rev Neurobiol. 2004; 61:31-48. Lopez MF, Melov S, Johnson F, Nagulko N, Golenko E, Kuzdzal S, Ackloo S, Mikulskis A. PMID: 15482810.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    80. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol. 2003 Aug; 5(8):741-7. Parrinello S, Samper E, Krtolica A, Goldstein J, Melov S, Campisi J. PMID: 12855956; PMCID: PMC4940195.
      View in: PubMed   Mentions: 451     Fields:    Translation:HumansAnimalsCells
    81. Microarray workshop on aging. Mech Ageing Dev. 2003 Jan; 124(1):133-8. Nair PN, Golden T, Melov S. PMID: 12618016.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    82. Oxidative stress and aging: beyond correlation. Aging Cell. 2002 Dec; 1(2):117-23. Golden TR, Hinerfeld DA, Melov S. PMID: 12882341.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    83. Spotlight on nematode mitochondria in RNAi mega-screen. Sci Aging Knowledge Environ. 2002 Nov 27; 2002(47):pe18. Melov S. PMID: 14603016.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    84. Animal models of oxidative stress, aging, and therapeutic antioxidant interventions. Int J Biochem Cell Biol. 2002 Nov; 34(11):1395-400. Melov S. PMID: 12200034.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    85. Therapeutics against mitochondrial oxidative stress in animal models of aging. Ann N Y Acad Sci. 2002 Apr; 959:330-40. Melov S. PMID: 11976207.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    86. Applied proteomics: mitochondrial proteins and effect on function. Circ Res. 2002 Mar 08; 90(4):380-9. Lopez MF, Melov S. PMID: 11884366.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    87. '...and C is for Clioquinol' - the AbetaCs of Alzheimer's disease. Trends Neurosci. 2002 Mar; 25(3):121-3; discussion 123-4. Melov S. PMID: 11852134.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
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