Sita Reddy, PhD

Title(s)Associate Professor of Biochemistry & Molecular Medicine
SchoolKeck School of Medicine of USC
Phone+1 323 442 2457
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanism of Small Molecule Mediated Rescue of Mytonic Dystrophy
    NIH/NINDS R01NS080547Apr 1, 2013 - Mar 31, 2018
    Role: Principal Investigator
    Identification of Therapeutic Small Molecules for Myotonic Dystrophy Type 1
    NIH/NINDS R21NS077722Sep 30, 2011 - Aug 31, 2014
    Role: Principal Investigator
    High Throughput Screen for Myotonic Dystrophy Type 1
    NIH/NIMH R03MH095544Jul 22, 2011 - Jun 30, 2012
    Role: Principal Investigator
    Biochemical analyses of muscleblind complexes in myotonic dystrophy
    NIH/NINDS R01NS060839Feb 1, 2007 - Nov 30, 2014
    Role: Principal Investigator
    Molecular Mechanisms Underlying DM1
    NIH/NINDS R01NS050861Jul 8, 2006 - Jun 30, 2012
    Role: Principal Investigator
    NIH/NINDS R01NS041116Sep 1, 2000 - Aug 31, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Jog SP, Paul S, Dansithong W, Tring S, Comai L, Reddy S. RNA splicing is responsive to MBNL1 dose. PLoS One. 2012; 7(11):e48825. PMID: 23166594; PMCID: PMC3499511.
    2. Wang ET, Cody NA, Jog S, Biancolella M, Wang TT, Treacy DJ, Luo S, Schroth GP, Housman DE, Reddy S, Lécuyer E, Burge CB. Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins. Cell. 2012 Aug 17; 150(4):710-24. PMID: 22901804; PMCID: PMC3428802.
    3. Candelario J, Chen LY, Marjoram P, Reddy S, Comai L. A filtering strategy identifies FOXQ1 as a potential effector of lamin A dysfunction. Aging (Albany NY). 2012 Aug; 4(8):567-77. PMID: 22948034; PMCID: PMC3461344.
    4. Paul S, Dansithong W, Jog SP, Holt I, Mittal S, Brook JD, Morris GE, Comai L, Reddy S. Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complex. J Biol Chem. 2011 Nov 04; 286(44):38427-38. PMID: 21900255; PMCID: PMC3207417.
    5. Reddy S, Comai L. Lamin A, farnesylation and aging. Exp Cell Res. 2012 Jan 01; 318(1):1-7. PMID: 21871450; PMCID: PMC4209918.
    6. Dansithong W, Jog SP, Paul S, Mohammadzadeh R, Tring S, Kwok Y, Fry RC, Marjoram P, Comai L, Reddy S. RNA steady-state defects in myotonic dystrophy are linked to nuclear exclusion of SHARP. EMBO Rep. 2011 Jul 01; 12(7):735-42. PMID: 21637295; PMCID: PMC3128970.
    7. Jog SP, Reddy S, Comai L. Cell cycle-regulated association between the Werner syndrome protein and its molecular partners. Cell Cycle. 2011 Jun 15; 10(12):2038-40. PMID: 21558813; PMCID: PMC3154421.
    8. Li B, Reddy S, Comai L. Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cells. Aging (Albany NY). 2011 Apr; 3(4):395-406. PMID: 21512205; PMCID: PMC3117455.
    9. Candelario J, Borrego S, Reddy S, Comai L. Accumulation of distinct prelamin A variants in human diploid fibroblasts differentially affects cell homeostasis. Exp Cell Res. 2011 Feb 01; 317(3):319-29. PMID: 20974128.
      View in: PubMed
    10. Reddy S, Li B, Comai L. Processing of human telomeres by the Werner syndrome protein. Cell Cycle. 2010 Aug 15; 9(16):3137-8. PMID: 20814240; PMCID: PMC3050012.
    11. Sen S, Talukdar I, Liu Y, Tam J, Reddy S, Webster NJ. Muscleblind-like 1 (Mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer. J Biol Chem. 2010 Aug 13; 285(33):25426-37. PMID: 20519504; PMCID: PMC2919106.
    12. Matynia A, Ng CH, Dansithong W, Chiang A, Silva AJ, Reddy S. Muscleblind1, but not Dmpk or Six5, contributes to a complex phenotype of muscular and motivational deficits in mouse models of myotonic dystrophy. PLoS One. 2010 Mar 25; 5(3):e9857. PMID: 20360842; PMCID: PMC2845609.
    13. Li B, Jog S, Candelario J, Reddy S, Comai L. Altered nuclear functions in progeroid syndromes: a paradigm for aging research. ScientificWorldJournal. 2009 Dec 16; 9:1449-62. PMID: 20024518.
      View in: PubMed
    14. Li B, Reddy S, Comai L. Sequence-specific processing of telomeric 3' overhangs by the Werner syndrome protein exonuclease activity. Aging (Albany NY). 2009 Mar 17; 1(3):289-302. PMID: 20157518; PMCID: PMC2806009.
    15. Dansithong W, Wolf CM, Sarkar P, Paul S, Chiang A, Holt I, Morris GE, Branco D, Sherwood MC, Comai L, Berul CI, Reddy S. Cytoplasmic CUG RNA foci are insufficient to elicit key DM1 features. PLoS One. 2008; 3(12):e3968. PMID: 19092997; PMCID: PMC2597774.
    16. Candelario J, Sudhakar S, Navarro S, Reddy S, Comai L. Perturbation of wild-type lamin A metabolism results in a progeroid phenotype. Aging Cell. 2008 Jun; 7(3):355-67. PMID: 18363904; PMCID: PMC2527236.
    17. Li B, Jog SP, Reddy S, Comai L. WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening. Mol Cell Biol. 2008 Mar; 28(6):1892-904. PMID: 18212065; PMCID: PMC2268394.
    18. Llagostera E, Catalucci D, Marti L, Liesa M, Camps M, Ciaraldi TP, Kondo R, Reddy S, Dillmann WH, Palacin M, Zorzano A, Ruiz-Lozano P, Gomis R, Kaliman P. Role of myotonic dystrophy protein kinase (DMPK) in glucose homeostasis and muscle insulin action. PLoS One. 2007 Nov 07; 2(11):e1134. PMID: 17987120; PMCID: PMC2043489.
    19. Lin CY, Navarro S, Reddy S, Comai L. CK2-mediated stimulation of Pol I transcription by stabilization of UBF-SL1 interaction. Nucleic Acids Res. 2006; 34(17):4752-66. PMID: 16971462; PMCID: PMC1635259.
    20. Paul S, Dansithong W, Kim D, Rossi J, Webster NJ, Comai L, Reddy S. Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing. EMBO J. 2006 Sep 20; 25(18):4271-83. PMID: 16946708; PMCID: PMC1570429.
    21. Salvatori S, Fanin M, Trevisan CP, Furlan S, Reddy S, Nagy JI, Angelini C. Decreased expression of DMPK: correlation with CTG repeat expansion and fibre type composition in myotonic dystrophy type 1. Neurol Sci. 2005 Oct; 26(4):235-42. PMID: 16193250.
      View in: PubMed
    22. Personius KE, Nautiyal J, Reddy S. Myotonia and muscle contractile properties in mice with SIX5 deficiency. Muscle Nerve. 2005 Apr; 31(4):503-5. PMID: 15536612.
      View in: PubMed
    23. Kaliman P, Catalucci D, Lam JT, Kondo R, Gutiérrez JC, Reddy S, Palacín M, Zorzano A, Chien KR, Ruiz-Lozano P. Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum. J Biol Chem. 2005 Mar 04; 280(9):8016-21. PMID: 15598648.
      View in: PubMed
    24. Dansithong W, Paul S, Comai L, Reddy S. MBNL1 is the primary determinant of focus formation and aberrant insulin receptor splicing in DM1. J Biol Chem. 2005 Feb 18; 280(7):5773-80. PMID: 15546872.
      View in: PubMed
    25. Sarkar PS, Han J, Reddy S. In situ hybridization analysis of Dmpk mRNA in adult mouse tissues. Neuromuscul Disord. 2004 Sep; 14(8-9):497-506. PMID: 15336691.
      View in: PubMed
    26. Sarkar PS, Paul S, Han J, Reddy S. Six5 is required for spermatogenic cell survival and spermiogenesis. Hum Mol Genet. 2004 Jul 15; 13(14):1421-31. PMID: 15163633.
      View in: PubMed
    27. Lee HC, Patel MK, Mistry DJ, Wang Q, Reddy S, Moorman JR, Mounsey JP. Abnormal Na channel gating in murine cardiac myocytes deficient in myotonic dystrophy protein kinase. Physiol Genomics. 2003 Jan 15; 12(2):147-57. PMID: 12454205.
      View in: PubMed
    28. Wakimoto H, Maguire CT, Sherwood MC, Vargas MM, Sarkar PS, Han J, Reddy S, Berul CI. Characterization of cardiac conduction system abnormalities in mice with targeted disruption of Six5 gene. J Interv Card Electrophysiol. 2002 Oct; 7(2):127-35. PMID: 12397222.
      View in: PubMed
    29. Reddy S, Mistry DJ, Wang QC, Geddis LM, Kutchai HC, Moorman JR, Mounsey JP. Effects of age and gene dose on skeletal muscle sodium channel gating in mice deficient in myotonic dystrophy protein kinase. Muscle Nerve. 2002 Jun; 25(6):850-7. PMID: 12115974.
      View in: PubMed
    30. Mistry DJ, Moorman JR, Reddy S, Mounsey JP. Skeletal muscle Na currents in mice heterozygous for Six5 deficiency. Physiol Genomics. 2001 Aug 28; 6(3):153-8. PMID: 11526199.
      View in: PubMed
    31. Timchenko NA, Cai ZJ, Welm AL, Reddy S, Ashizawa T, Timchenko LT. RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1. J Biol Chem. 2001 Mar 16; 276(11):7820-6. PMID: 11124939.
      View in: PubMed
    32. Mounsey JP, Mistry DJ, Ai CW, Reddy S, Moorman JR. Skeletal muscle sodium channel gating in mice deficient in myotonic dystrophy protein kinase. Hum Mol Genet. 2000 Sep 22; 9(15):2313-20. PMID: 11001935.
      View in: PubMed
    33. Berul CI, Maguire CT, Gehrmann J, Reddy S. Progressive atrioventricular conduction block in a mouse myotonic dystrophy model. J Interv Card Electrophysiol. 2000 Jun; 4(2):351-8. PMID: 10936001.
      View in: PubMed
    34. Sarkar PS, Appukuttan B, Han J, Ito Y, Ai C, Tsai W, Chai Y, Stout JT, Reddy S. Heterozygous loss of Six5 in mice is sufficient to cause ocular cataracts. Nat Genet. 2000 May; 25(1):110-4. PMID: 10802668.
      View in: PubMed
    35. Saba S, Vanderbrink BA, Luciano B, Aronovitz MJ, Berul CI, Reddy S, Housman D, Mendelsohn ME, Estes NA, Wang PJ. Localization of the sites of conduction abnormalities in a mouse model of myotonic dystrophy. J Cardiovasc Electrophysiol. 1999 Sep; 10(9):1214-20. PMID: 10517654.
      View in: PubMed
    36. Berul CI, Maguire CT, Aronovitz MJ, Greenwood J, Miller C, Gehrmann J, Housman D, Mendelsohn ME, Reddy S. DMPK dosage alterations result in atrioventricular conduction abnormalities in a mouse myotonic dystrophy model. J Clin Invest. 1999 Feb; 103(4):R1-7. PMID: 10021468; PMCID: PMC408103.
    37. Sarkar PS, Chang HC, Boudi FB, Reddy S. CTG repeats show bimodal amplification in E. coli. Cell. 1998 Nov 13; 95(4):531-40. PMID: 9827805.
      View in: PubMed
    38. Roberts R, Timchenko NA, Miller JW, Reddy S, Caskey CT, Swanson MS, Timchenko LT. Altered phosphorylation and intracellular distribution of a (CUG)n triplet repeat RNA-binding protein in patients with myotonic dystrophy and in myotonin protein kinase knockout mice. Proc Natl Acad Sci U S A. 1997 Nov 25; 94(24):13221-6. PMID: 9371827; PMCID: PMC24290.
    39. Reddy S, Smith DB, Rich MM, Leferovich JM, Reilly P, Davis BM, Tran K, Rayburn H, Bronson R, Cros D, Balice-Gordon RJ, Housman D. Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy. Nat Genet. 1996 Jul; 13(3):325-35. PMID: 8673132.
      View in: PubMed