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Sita Reddy, PhD

Title(s)Associate Professor of Biochemistry & Molecular Medicine
AddressHMR 702A, HRM 704, 2011 Zonal Avenue
Health Sciences Campus
Los Angeles CA 90089
Phone+1 323 442 2457
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanism of Small Molecule Mediated Rescue of Mytonic Dystrophy
    NIH/NINDS R01NS080547Apr 1, 2013 - Mar 31, 2018
    Role: Principal Investigator
    Identification of Therapeutic Small Molecules for Myotonic Dystrophy Type 1
    NIH/NINDS R21NS077722Sep 30, 2011 - Aug 31, 2014
    Role: Principal Investigator
    High Throughput Screen for Myotonic Dystrophy Type 1
    NIH/NIMH R03MH095544Jul 22, 2011 - Jun 30, 2012
    Role: Principal Investigator
    Biochemical analyses of muscleblind complexes in myotonic dystrophy
    NIH/NINDS R01NS060839Feb 1, 2007 - Nov 30, 2014
    Role: Principal Investigator
    Molecular Mechanisms Underlying DM1
    NIH/NINDS R01NS050861Jul 8, 2006 - Jun 30, 2012
    Role: Principal Investigator
    MOLECULAR MECHANISMS WHEREBY CTG EXPANSION RESULTS IN DM
    NIH/NINDS R01NS041116Sep 1, 2000 - Aug 31, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. RNA splicing is responsive to MBNL1 dose. PLoS One. 2012; 7(11):e48825. Jog SP, Paul S, Dansithong W, Tring S, Comai L, Reddy S. PMID: 23166594.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    2. Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins. Cell. 2012 Aug 17; 150(4):710-24. Wang ET, Cody NA, Jog S, Biancolella M, Wang TT, Treacy DJ, Luo S, Schroth GP, Housman DE, Reddy S, Lécuyer E, Burge CB. PMID: 22901804.
      View in: PubMed   Mentions: 194     Fields:    Translation:AnimalsCells
    3. A filtering strategy identifies FOXQ1 as a potential effector of lamin A dysfunction. Aging (Albany NY). 2012 Aug; 4(8):567-77. Candelario J, Chen LY, Marjoram P, Reddy S, Comai L. PMID: 22948034.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    4. Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complex. J Biol Chem. 2011 Nov 04; 286(44):38427-38. Paul S, Dansithong W, Jog SP, Holt I, Mittal S, Brook JD, Morris GE, Comai L, Reddy S. PMID: 21900255.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    5. Lamin A, farnesylation and aging. Exp Cell Res. 2012 Jan 01; 318(1):1-7. Reddy S, Comai L. PMID: 21871450.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    6. RNA steady-state defects in myotonic dystrophy are linked to nuclear exclusion of SHARP. . 2011 Jul 01; 12(7):735-42. Dansithong W, Jog SP, Paul S, Mohammadzadeh R, Tring S, Kwok Y, Fry RC, Marjoram P, Comai L, Reddy S. PMID: 21637295.
      View in: PubMed   Mentions:
    7. Cell cycle-regulated association between the Werner syndrome protein and its molecular partners. . 2011 Jun 15; 10(12):2038-40. Jog SP, Reddy S, Comai L. PMID: 21558813.
      View in: PubMed   Mentions:
    8. Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cells. Aging (Albany NY). 2011 Apr; 3(4):395-406. Li B, Reddy S, Comai L. PMID: 21512205.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    9. Accumulation of distinct prelamin A variants in human diploid fibroblasts differentially affects cell homeostasis. Exp Cell Res. 2011 Feb 01; 317(3):319-29. Candelario J, Borrego S, Reddy S, Comai L. PMID: 20974128.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    10. Processing of human telomeres by the Werner syndrome protein. . 2010 Aug 15; 9(16):3137-8. Reddy S, Li B, Comai L. PMID: 20814240.
      View in: PubMed   Mentions:
    11. Muscleblind-like 1 (Mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer. J Biol Chem. 2010 Aug 13; 285(33):25426-37. Sen S, Talukdar I, Liu Y, Tam J, Reddy S, Webster NJ. PMID: 20519504.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    12. Muscleblind1, but not Dmpk or Six5, contributes to a complex phenotype of muscular and motivational deficits in mouse models of myotonic dystrophy. PLoS One. 2010 Mar 25; 5(3):e9857. Matynia A, Ng CH, Dansithong W, Chiang A, Silva AJ, Reddy S. PMID: 20360842.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    13. Altered nuclear functions in progeroid syndromes: a paradigm for aging research. ScientificWorldJournal. 2009 Dec 16; 9:1449-62. Li B, Jog S, Candelario J, Reddy S, Comai L. PMID: 20024518.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    14. Sequence-specific processing of telomeric 3' overhangs by the Werner syndrome protein exonuclease activity. Aging (Albany NY). 2009 Mar 17; 1(3):289-302. Li B, Reddy S, Comai L. PMID: 20157518.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    15. Cytoplasmic CUG RNA foci are insufficient to elicit key DM1 features. PLoS One. 2008; 3(12):e3968. Dansithong W, Wolf CM, Sarkar P, Paul S, Chiang A, Holt I, Morris GE, Branco D, Sherwood MC, Comai L, Berul CI, Reddy S. PMID: 19092997.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    16. Perturbation of wild-type lamin A metabolism results in a progeroid phenotype. Aging Cell. 2008 Jun; 7(3):355-67. Candelario J, Sudhakar S, Navarro S, Reddy S, Comai L. PMID: 18363904.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    17. WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening. Mol Cell Biol. 2008 Mar; 28(6):1892-904. Li B, Jog SP, Reddy S, Comai L. PMID: 18212065.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    18. Role of myotonic dystrophy protein kinase (DMPK) in glucose homeostasis and muscle insulin action. PLoS One. 2007 Nov 07; 2(11):e1134. Llagostera E, Catalucci D, Marti L, Liesa M, Camps M, Ciaraldi TP, Kondo R, Reddy S, Dillmann WH, Palacin M, Zorzano A, Ruiz-Lozano P, Gomis R, Kaliman P. PMID: 17987120.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    19. CK2-mediated stimulation of Pol I transcription by stabilization of UBF-SL1 interaction. Nucleic Acids Res. 2006; 34(17):4752-66. Lin CY, Navarro S, Reddy S, Comai L. PMID: 16971462.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    20. Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing. EMBO J. 2006 Sep 20; 25(18):4271-83. Paul S, Dansithong W, Kim D, Rossi J, Webster NJ, Comai L, Reddy S. PMID: 16946708.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    21. Decreased expression of DMPK: correlation with CTG repeat expansion and fibre type composition in myotonic dystrophy type 1. Neurol Sci. 2005 Oct; 26(4):235-42. Salvatori S, Fanin M, Trevisan CP, Furlan S, Reddy S, Nagy JI, Angelini C. PMID: 16193250.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    22. Myotonia and muscle contractile properties in mice with SIX5 deficiency. Muscle Nerve. 2005 Apr; 31(4):503-5. Personius KE, Nautiyal J, Reddy S. PMID: 15536612.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    23. Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum. J Biol Chem. 2005 Mar 04; 280(9):8016-21. Kaliman P, Catalucci D, Lam JT, Kondo R, Gutiérrez JC, Reddy S, Palacín M, Zorzano A, Chien KR, Ruiz-Lozano P. PMID: 15598648.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    24. MBNL1 is the primary determinant of focus formation and aberrant insulin receptor splicing in DM1. J Biol Chem. 2005 Feb 18; 280(7):5773-80. Dansithong W, Paul S, Comai L, Reddy S. PMID: 15546872.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    25. In situ hybridization analysis of Dmpk mRNA in adult mouse tissues. Neuromuscul Disord. 2004 Sep; 14(8-9):497-506. Sarkar PS, Han J, Reddy S. PMID: 15336691.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    26. Six5 is required for spermatogenic cell survival and spermiogenesis. Hum Mol Genet. 2004 Jul 15; 13(14):1421-31. Sarkar PS, Paul S, Han J, Reddy S. PMID: 15163633.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    27. Abnormal Na channel gating in murine cardiac myocytes deficient in myotonic dystrophy protein kinase. Physiol Genomics. 2003 Jan 15; 12(2):147-57. Lee HC, Patel MK, Mistry DJ, Wang Q, Reddy S, Moorman JR, Mounsey JP. PMID: 12454205.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    28. Characterization of cardiac conduction system abnormalities in mice with targeted disruption of Six5 gene. J Interv Card Electrophysiol. 2002 Oct; 7(2):127-35. Wakimoto H, Maguire CT, Sherwood MC, Vargas MM, Sarkar PS, Han J, Reddy S, Berul CI. PMID: 12397222.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    29. Effects of age and gene dose on skeletal muscle sodium channel gating in mice deficient in myotonic dystrophy protein kinase. Muscle Nerve. 2002 Jun; 25(6):850-7. Reddy S, Mistry DJ, Wang QC, Geddis LM, Kutchai HC, Moorman JR, Mounsey JP. PMID: 12115974.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    30. Skeletal muscle Na currents in mice heterozygous for Six5 deficiency. Physiol Genomics. 2001 Aug 28; 6(3):153-8. Mistry DJ, Moorman JR, Reddy S, Mounsey JP. PMID: 11526199.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    31. RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1. J Biol Chem. 2001 Mar 16; 276(11):7820-6. Timchenko NA, Cai ZJ, Welm AL, Reddy S, Ashizawa T, Timchenko LT. PMID: 11124939.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    32. Skeletal muscle sodium channel gating in mice deficient in myotonic dystrophy protein kinase. Hum Mol Genet. 2000 Sep 22; 9(15):2313-20. Mounsey JP, Mistry DJ, Ai CW, Reddy S, Moorman JR. PMID: 11001935.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    33. Progressive atrioventricular conduction block in a mouse myotonic dystrophy model. J Interv Card Electrophysiol. 2000 Jun; 4(2):351-8. Berul CI, Maguire CT, Gehrmann J, Reddy S. PMID: 10936001.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    34. Heterozygous loss of Six5 in mice is sufficient to cause ocular cataracts. Nat Genet. 2000 May; 25(1):110-4. Sarkar PS, Appukuttan B, Han J, Ito Y, Ai C, Tsai W, Chai Y, Stout JT, Reddy S. PMID: 10802668.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    35. Localization of the sites of conduction abnormalities in a mouse model of myotonic dystrophy. J Cardiovasc Electrophysiol. 1999 Sep; 10(9):1214-20. Saba S, Vanderbrink BA, Luciano B, Aronovitz MJ, Berul CI, Reddy S, Housman D, Mendelsohn ME, Estes NA, Wang PJ. PMID: 10517654.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    36. DMPK dosage alterations result in atrioventricular conduction abnormalities in a mouse myotonic dystrophy model. J Clin Invest. 1999 Feb; 103(4):R1-7. Berul CI, Maguire CT, Aronovitz MJ, Greenwood J, Miller C, Gehrmann J, Housman D, Mendelsohn ME, Reddy S. PMID: 10021468.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    37. CTG repeats show bimodal amplification in E. coli. Cell. 1998 Nov 13; 95(4):531-40. Sarkar PS, Chang HC, Boudi FB, Reddy S. PMID: 9827805.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    38. Altered phosphorylation and intracellular distribution of a (CUG)n triplet repeat RNA-binding protein in patients with myotonic dystrophy and in myotonin protein kinase knockout mice. Proc Natl Acad Sci U S A. 1997 Nov 25; 94(24):13221-6. Roberts R, Timchenko NA, Miller JW, Reddy S, Caskey CT, Swanson MS, Timchenko LT. PMID: 9371827.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    39. Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy. Nat Genet. 1996 Jul; 13(3):325-35. Reddy S, Smith DB, Rich MM, Leferovich JM, Reilly P, Davis BM, Tran K, Rayburn H, Bronson R, Cros D, Balice-Gordon RJ, Housman D. PMID: 8673132.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
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