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Development of a cystic fibrosis population model for physiologically based pharmacokinetic models: Is it worth it? CPT Pharmacometrics Syst Pharmacol. 2024 04; 13(4):509-510.
Hong E, Beringer PM. PMID: 38511610; PMCID: PMC11015069.
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PubMed Mentions: Fields:
Translation:
Humans
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Pharmacokinetic Enhancement of Elexacaftor/Tezacaftor/Ivacaftor for Cystic Fibrosis: A Cost Reduction Strategy to Address Global Disparities in Access. Clin Pharmacol Ther. 2024 Jun; 115(6):1204-1207.
Hong E, Zampoli M, Beringer PM. PMID: 38385853.
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PubMed Mentions: Fields:
Translation:
Humans
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Drug-induced liver injury associated with elexacaftor/tezacaftor/ivacaftor: A pharmacovigilance analysis of the FDA adverse event reporting system (FAERS). J Cyst Fibros. 2024 May; 23(3):566-572.
Shi A, Nguyen H, Kuo CB, Beringer PM. PMID: 38233246.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Preliminary evidence for sustained efficacy of CFTR modulator therapy with concomitant rifabutin administration. J Cyst Fibros. 2024 May; 23(3):519-523.
Hong E, Parsons SM, Sass L, Epstein C, Chan L, Brown C, Eshaghian PH, Beringer PM. PMID: 38036321.
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PubMed Mentions: Fields:
Translation:
Humans
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Drug-drug interactions involving CFTR modulators: a review of the evidence and clinical implications. Expert Opin Drug Metab Toxicol. 2023 Apr; 19(4):203-216.
Hong E, Shi A, Beringer P. PMID: 37259485.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Application of Physiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions between Elexacaftor/Tezacaftor/Ivacaftor and Tacrolimus in Lung Transplant Recipients. Pharmaceutics. 2023 May 08; 15(5).
Hong E, Carmanov E, Shi A, Chung PS, Rao AP, Forrester K, Beringer PM. PMID: 37242680; PMCID: PMC10222456.
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PubMed Mentions:
3
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Safety of elexacaftor/tezacaftor/ivacaftor dose reduction: Mechanistic exploration through physiologically based pharmacokinetic modeling and a clinical case series. Pharmacotherapy. 2023 04; 43(4):291-299.
Hong E, Li R, Shi A, Almond LM, Wang J, Khudari AZ, Haddad S, Sislyan S, Angelich M, Chung PS, Rao AP, Beringer PM. PMID: 36866442.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Physiologically Based Pharmacokinetic Modeling To Guide Management of Drug Interactions between Elexacaftor-Tezacaftor-Ivacaftor and Antibiotics for the Treatment of Nontuberculous Mycobacteria. Antimicrob Agents Chemother. 2022 11 15; 66(11):e0110422.
Hong E, Almond LM, Chung PS, Rao AP, Beringer PM. PMID: 36286508; PMCID: PMC9664863.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Physiologically-Based Pharmacokinetic-Led Guidance for Patients With Cystic Fibrosis Taking Elexacaftor-Tezacaftor-Ivacaftor With Nirmatrelvir-Ritonavir for the Treatment of COVID-19. Clin Pharmacol Ther. 2022 06; 111(6):1324-1333.
Hong E, Almond LM, Chung PS, Rao AP, Beringer PM. PMID: 35292968; PMCID: PMC9087007.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Preclinical Pharmacokinetics and Safety of Intravenous RTD-1. Antimicrob Agents Chemother. 2022 03 15; 66(3):e0212521.
Park AYJ, Tran DQ, Schaal JB, Wang M, Selsted ME, Beringer PM. PMID: 35041507; PMCID: PMC8923172.
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PubMed Mentions:
2 Fields:
Translation:
Animals
-
Corrigendum to: Enhanced brain delivery and therapeutic activity of trastuzumab after blood-brain barrier opening by NEO100 in mouse models of brain-metastatic breast cancer. Neuro Oncol. 2021 Dec 01; 23(12):2123.
Wang W, He H, Marín-Ramos NI, Zeng S, Swenson SD, Cho HY, Fu J, Beringer PM, Neman J, Chen L, Schönthal AH, Chen TC. PMID: 34519783; PMCID: PMC8643429.
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PubMed Mentions: Fields:
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Chemical Synthesis of a Potent Antimicrobial Peptide Murepavadin Using a Tandem Native Chemical Ligation/Desulfurization Reaction. J Org Chem. 2021 11 05; 86(21):15242-15246.
Chaudhuri D, Ganesan R, Vogelaar A, Dughbaj MA, Beringer PM, Camarero JA. PMID: 34641669; PMCID: PMC8935662.
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PubMed Mentions:
4 Fields:
Translation:
Cells
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Enhanced brain delivery and therapeutic activity of trastuzumab after blood-brain barrier opening by NEO100 in mouse models of brain-metastatic breast cancer. Neuro Oncol. 2021 10 01; 23(10):1656-1667.
Wang W, He H, Marín-Ramos NI, Zeng S, Swenson SD, Cho HY, Fu J, Beringer PM, Neman J, Chen L, Schönthal AH, Chen TC. PMID: 33659980; PMCID: PMC8485439.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Anti-Inflammatory Effects of RTD-1 in a Murine Model of Chronic Pseudomonas aeruginosa Lung Infection: Inhibition of NF-κB, Inflammasome Gene Expression, and Pro-IL-1β Biosynthesis. Antibiotics (Basel). 2021 Aug 26; 10(9).
Dughbaj MA, Jayne JG, Park AYJ, Bensman TJ, Algorri M, Ouellette AJ, Selsted ME, Beringer PM. PMID: 34572625; PMCID: PMC8466744.
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PubMed Mentions:
3
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Engineered Cyclotides with Potent Broad in Vitro and in Vivo Antimicrobial Activity. Chemistry. 2021 Sep 01; 27(49):12702-12708.
Ganesan R, Dughbaj MA, Ramirez L, Beringer S, Aboye TL, Shekhtman A, Beringer PM, Camarero JA. PMID: 34159664; PMCID: PMC8410672.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Rhesus Theta Defensin 1 Promotes Long Term Survival in Systemic Candidiasis by Host Directed Mechanisms. Sci Rep. 2019 11 15; 9(1):16905.
Basso V, Tran DQ, Schaal JB, Tran P, Eriguchi Y, Ngole D, Cabebe AE, Park AY, Beringer PM, Ouellette AJ, Selsted ME. PMID: 31729441; PMCID: PMC6858451.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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The Potential for QT Interval Prolongation with Chronic Azithromycin Therapy in Adult Cystic Fibrosis Patients. Pharmacotherapy. 2019 06; 39(6):718-723.
Avedissian SN, Rhodes NJ, Ng TMH, Rao AP, Beringer PM. PMID: 31045258.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Pharmacokinetics of Tedizolid in Plasma and Sputum of Adults with Cystic Fibrosis. Antimicrob Agents Chemother. 2018 09; 62(9).
Park AYJ, Wang J, Jayne J, Fukushima L, Rao AP, D'Argenio DZ, Beringer PM. PMID: 29914949; PMCID: PMC6125567.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Rhesus θ-Defensin-1 Attenuates Endotoxin-induced Acute Lung Injury by Inhibiting Proinflammatory Cytokines and Neutrophil Recruitment. Am J Respir Cell Mol Biol. 2018 03; 58(3):310-319.
Jayne JG, Bensman TJ, Schaal JB, Park AYJ, Kimura E, Tran D, Selsted ME, Beringer PM. PMID: 28954201; PMCID: PMC5854954.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Suppression and resolution of autoimmune arthritis by rhesus θ-defensin-1, an immunomodulatory macrocyclic peptide. PLoS One. 2017; 12(11):e0187868.
Schaal JB, Tran DQ, Subramanian A, Patel R, Laragione T, Roberts KD, Trinh K, Tongaonkar P, Tran PA, Minond D, Fields GB, Beringer P, Ouellette AJ, Gulko PS, Selsted ME. PMID: 29145473; PMCID: PMC5690597.
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PubMed Mentions:
12 Fields:
Translation:
Animals
-
Pharmacokinetic-Pharmacodynamic Target Attainment Analyses To Determine Optimal Dosing of Ceftazidime-Avibactam for the Treatment of Acute Pulmonary Exacerbations in Patients with Cystic Fibrosis. Antimicrob Agents Chemother. 2017 10; 61(10).
Bensman TJ, Wang J, Jayne J, Fukushima L, Rao AP, D'Argenio DZ, Beringer PM. PMID: 28784670; PMCID: PMC5610479.
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PubMed Mentions:
19 Fields:
Translation:
HumansCellsCTClinical Trials
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Efficacy of Rhesus Theta-Defensin-1 in Experimental Models of Pseudomonas aeruginosa Lung Infection and Inflammation. Antimicrob Agents Chemother. 2017 08; 61(8).
Bensman TJ, Jayne JG, Sun M, Kimura E, Meinert J, Wang JC, Schaal JB, Tran D, Rao AP, Akbari O, Selsted ME, Beringer PM. PMID: 28559270; PMCID: PMC5527632.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Subregional laminar cartilage MR spin-spin relaxation times (T2) in osteoarthritic knees with and without medial femorotibial cartilage loss - data from the Osteoarthritis Initiative (OAI). Osteoarthritis Cartilage. 2017 08; 25(8):1313-1323.
Wirth W, Maschek S, Beringer P, Eckstein F. PMID: 28351705; PMCID: PMC5522340.
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PubMed Mentions:
4 Fields:
Translation:
HumansCTClinical Trials
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Rhesus θ-defensin-1 (RTD-1) exhibits in vitro and in vivo activity against cystic fibrosis strains of Pseudomonas aeruginosa. J Antimicrob Chemother. 2016 Jan; 71(1):181-8.
Beringer PM, Bensman TJ, Ho H, Agnello M, Denovel N, Nguyen A, Wong-Beringer A, She R, Tran DQ, Moskowitz SM, Selsted ME. PMID: 26433781; PMCID: PMC5007590.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Discovery of Novel CXCR2 Inhibitors Using Ligand-Based Pharmacophore Models. J Chem Inf Model. 2015 Aug 24; 55(8):1720-38.
Ha H, Debnath B, Odde S, Bensman T, Ho H, Beringer PM, Neamati N. PMID: 26153616.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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A novel phenylcyclohex-1-enecarbothioamide derivative inhibits CXCL8-mediated chemotaxis through selective regulation of CXCR2-mediated signalling. Br J Pharmacol. 2014 Mar; 171(6):1551-65.
Ha H, Bensman T, Ho H, Beringer PM, Neamati N. PMID: 24354854; PMCID: PMC3954492.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Doxycycline exhibits anti-inflammatory activity in CF bronchial epithelial cells. Pulm Pharmacol Ther. 2012 Oct; 25(5):377-82.
Bensman TJ, Nguyen AN, Rao AP, Beringer PM. PMID: 22771903.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Acute care clinical pharmacy practice: unit- versus service-based models. Pharmacotherapy. 2012 Feb; 32(2):e35-44.
American College of Clinical Pharmacy, Haas CE, Eckel S, Arif S, Beringer PM, Blake EW, Lardieri AB, Lobo BL, Mercer JM, Moye P, Orlando PL, Wargo K. PMID: 22392430.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Pharmacokinetics of doxycycline in adults with cystic fibrosis. Antimicrob Agents Chemother. 2012 Jan; 56(1):70-4.
Beringer PM, Owens H, Nguyen A, Benitez D, Rao A, D'Argenio DZ. PMID: 22024822; PMCID: PMC3256044.
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PubMed Mentions:
23 Fields:
Translation:
Humans
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Applying new diagnostic criteria for acute kidney injury to facilitate early identification of nephrotoxicity in vancomycin-treated patients. Antimicrob Agents Chemother. 2011 Jul; 55(7):3278-83.
Minejima E, Choi J, Beringer P, Lou M, Tse E, Wong-Beringer A. PMID: 21576448; PMCID: PMC3122454.
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PubMed Mentions:
38 Fields:
Translation:
Humans
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Vancomycin-associated nephrotoxicity: a critical appraisal of risk with high-dose therapy. Int J Antimicrob Agents. 2011 Feb; 37(2):95-101.
Wong-Beringer A, Joo J, Tse E, Beringer P. PMID: 21130609.
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PubMed Mentions:
61 Fields:
Translation:
HumansCells
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Estimation of glomerular filtration rate by using serum cystatin C and serum creatinine concentrations in patients with human immunodeficiency virus. Pharmacotherapy. 2010 Oct; 30(10):1004-10.
Beringer PM, Owens H, Nguyen A, Mordwinkin N, Louie S, Mak M, Sattler F. PMID: 20874037.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Recommended education for pharmacists as competitive clinical scientists. Pharmacotherapy. 2009 Feb; 29(2):236-44.
Dowling TC, Murphy JE, Kalus JS, Nkansah NT, Chappell JS, Wiederhold NP, Beringer P, Crews KR, Grabinski JL, Evens RP, Leff R, American College of Clinical Pharmacy. PMID: 19170592.
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PubMed Mentions:
11 Fields:
Translation:
Humans
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GFR estimates using cystatin C are superior to serum creatinine in adult patients with cystic fibrosis. J Cyst Fibros. 2009 Jan; 8(1):19-25.
Beringer PM, Hidayat L, Heed A, Zheng L, Owens H, Benitez D, Rao AP. PMID: 18799365.
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PubMed Mentions:
15 Fields:
Translation:
Humans
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Lack of effect of P-glycoprotein inhibition on renal clearance of dicloxacillin in patients with cystic fibrosis. Pharmacotherapy. 2008 Jul; 28(7):883-94.
Beringer PM, Kriengkauykiat J, Zhang X, Hidayat L, Liu S, Louie S, Synold T, Burckart GJ, Rao PA, Shapiro B, Gill M. PMID: 18576903.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Probenecid, but not cystic fibrosis, alters the total and renal clearance of fexofenadine. J Clin Pharmacol. 2008 Aug; 48(8):957-65.
Liu S, Beringer PM, Hidayat L, Rao AP, Louie S, Burckart GJ, Shapiro B. PMID: 18511651.
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PubMed Mentions:
8 Fields:
Translation:
HumansCellsCTClinical Trials
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Pilot study of continuous infusion cefepime in adult patients with cystic fibrosis. J Antimicrob Chemother. 2006 May; 57(5):1017-9.
Han EE, Beringer PM, Falck P, Louie S, Rao P, Shapiro B, Gill M. PMID: 16533828.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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Absolute bioavailability and intracellular pharmacokinetics of azithromycin in patients with cystic fibrosis. Antimicrob Agents Chemother. 2005 Dec; 49(12):5013-7.
Beringer P, Huynh KM, Kriengkauykiat J, Bi L, Hoem N, Louie S, Han E, Nguyen T, Hsu D, Rao PA, Shapiro B, Gill M. PMID: 16304166; PMCID: PMC1315964.
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PubMed Mentions:
19 Fields:
Translation:
Humans
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Suitability of caspofungin for aerosol delivery: physicochemical profiling and nebulizer choice. Chest. 2005 Nov; 128(5):3711-6.
Wong-Beringer A, Lambros MP, Beringer PM, Johnson DL. PMID: 16304338.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Absolute bioavailability and pharmacokinetics of linezolid in hospitalized patients given enteral feedings. Antimicrob Agents Chemother. 2005 Sep; 49(9):3676-81.
Beringer P, Nguyen M, Hoem N, Louie S, Gill M, Gurevitch M, Wong-Beringer A. PMID: 16127039; PMCID: PMC1195442.
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PubMed Mentions:
20 Fields:
Translation:
HumansCTClinical Trials
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Transporters and their impact on drug disposition. Ann Pharmacother. 2005 Jun; 39(6):1097-108.
Beringer PM, Slaughter RL. PMID: 15886292.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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Phase I clinical and pharmacokinetic trial of docetaxel and irinotecan administered on a weekly schedule. Cancer Chemother Pharmacol. 2005 Jul; 56(1):75-82.
Garcia AA, Pujari M, Jeffers S, Iqbal S, Lenz HJ, Beringer P, Louie S. PMID: 15809878.
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PubMed Mentions:
2 Fields:
Translation:
HumansCTClinical Trials
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A comparison of phenytoin-loading techniques in the emergency department. Acad Emerg Med. 2004 Mar; 11(3):244-52.
Swadron SP, Rudis MI, Azimian K, Beringer P, Fort D, Orlinsky M. PMID: 15001403.
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PubMed Mentions:
15 Fields:
Translation:
HumansCTClinical Trials
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Pharmacokinetics of Ibuprofen in children with cystic fibrosis. Clin Pharmacokinet. 2004; 43(3):145-56.
Han EE, Beringer PM, Louie SG, Gill MA, Shapiro BJ. PMID: 14871154.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Stability and antibacterial activity of cefepime during continuous infusion. Antimicrob Agents Chemother. 2003 Jun; 47(6):1991-4.
Sprauten PF, Beringer PM, Louie SG, Synold TW, Gill MA. PMID: 12760882; PMCID: PMC155835.
View in:
PubMed Mentions:
7 Fields:
Translation:
Cells
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Potential role of macrolide antibiotics in the management of cystic fibrosis lung disease. Curr Opin Pulm Med. 2002 Nov; 8(6):521-8.
Nguyen T, Louie SG, Beringer PM, Gill MA. PMID: 12394161.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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Distribution and elimination of tobramycin administered in single or multiple daily doses in adult patients with cystic fibrosis. J Antimicrob Chemother. 2002 Oct; 50(4):553-9.
Aminimanizani A, Beringer PM, Kang J, Tsang L, Jelliffe RW, Shapiro BJ. PMID: 12356801.
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PubMed Mentions:
16 Fields:
Translation:
Humans
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Development of population pharmacokinetic models and optimal sampling times for ibuprofen tablet and suspension formulations in children with cystic fibrosis. Ther Drug Monit. 2002 Apr; 24(2):315-21.
Beringer P, Aminimanizani A, Synold T, Scott C. PMID: 11897978.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Population pharmacokinetics and use of Monte Carlo simulation to evaluate currently recommended dosing regimens of ciprofloxacin in adult patients with cystic fibrosis. Antimicrob Agents Chemother. 2001 Dec; 45(12):3468-73.
Montgomery MJ, Beringer PM, Aminimanizani A, Louie SG, Shapiro BJ, Jelliffe R, Gill MA. PMID: 11709326; PMCID: PMC90855.
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PubMed Mentions:
16 Fields:
Translation:
HumansCellsCTClinical Trials
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The clinical use of colistin in patients with cystic fibrosis. Curr Opin Pulm Med. 2001 Nov; 7(6):434-40.
Beringer P. PMID: 11706322.
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PubMed Mentions:
40 Fields:
Translation:
HumansCells
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Comparative pharmacokinetics and pharmacodynamics of the newer fluoroquinolone antibacterials. Clin Pharmacokinet. 2001; 40(3):169-87.
Aminimanizani A, Beringer P, Jelliffe R. PMID: 11327197.
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PubMed Mentions:
30 Fields:
Translation:
Humans
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Estimation of creatinine clearance in patients with metastatic ovarian cancer. Ther Drug Monit. 2000 Dec; 22(6):695-700.
Montgomery MJ, Beringer PM, Louie SG, Gill MA. PMID: 11128237.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Unusual respiratory bacterial flora in cystic fibrosis: microbiologic and clinical features. Curr Opin Pulm Med. 2000 Nov; 6(6):545-50.
Beringer PM, Appleman MD. PMID: 11100967.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Pharmacokinetics of tobramycin in adults with cystic fibrosis: implications for once-daily administration. Antimicrob Agents Chemother. 2000 Apr; 44(4):809-13.
Beringer PM, Vinks AA, Jelliffe RW, Shapiro BJ. PMID: 10722474; PMCID: PMC89775.
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PubMed Mentions:
16 Fields:
Translation:
HumansCTClinical Trials
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New approaches to optimizing antimicrobial therapy in patients with cystic fibrosis. Curr Opin Pulm Med. 1999 Nov; 5(6):371-7.
Beringer PM. PMID: 10570739.
View in:
PubMed Mentions:
3 Fields:
Translation:
Humans
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Predictive performance of a vancomycin-aminoglycoside population model. Ann Pharmacother. 1998 Feb; 32(2):176-81.
Beringer PM, Wong-Beringer A, Rho JP. PMID: 9496400.
View in:
PubMed Mentions:
3 Fields:
Translation:
Humans
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Economic aspects of antibacterial adverse effects. Pharmacoeconomics. 1998 Jan; 13(1 Pt 1):35-49.
Beringer PM, Wong-Beringer A, Rho JP. PMID: 10175984.
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PubMed Mentions:
18 Fields:
Translation:
Humans
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Pharmacokinetics of once-daily amikacin dosing in patients with cystic fibrosis. J Antimicrob Chemother. 1998 Jan; 41(1):142-4.
Beringer PM, Vinks AA, Jelliffe RW. PMID: 9511054.
View in:
PubMed Mentions:
1 Fields:
Translation:
Humans
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Successful treatment of multidrug-resistant Pseudomonas aeruginosa meningitis with high-dose ciprofloxacin. Clin Infect Dis. 1997 Oct; 25(4):936-7.
Wong-Beringer A, Beringer P, Lovett MA. PMID: 9356822.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Is routine measurement of free phenytoin concentrations rational? Ther Drug Monit. 1995 Aug; 17(4):381-2.
Beringer PM, Rho JP. PMID: 7482694.
View in:
PubMed Mentions:
1 Fields:
Translation:
Humans