Prasad C. Tongaonkar, PhD

TitleAssistant Professor of Research Pathology
InstitutionUniversity of Southern California
AddressNRT 1450 Biggy St
Health Sciences Campus
Los Angeles CA 90089-9601
Phone+1 323 442 7960
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    Collapse Research 
    Collapse Research Activities and Funding
    Post-translational processing of myeloid alpha-defensins.
    NIH/NIAID R56AI078321Aug 15, 2010 - Jul 31, 2013
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Basso V, Garcia A, Tran DQ, Schaal JB, Tran P, Ngole D, Aqeel Y, Tongaonkar P, Ouellette AJ, Selsted ME. Fungicidal potency and mechanisms of ?-defensins against multi-drug resistant Candida species. Antimicrob Agents Chemother. 2018 Apr 02. PMID: 29610196.
      View in: PubMed
    2. Schaal JB, Maretzky T, Tran DQ, Tran PA, Tongaonkar P, Blobel CP, Ouellette AJ, Selsted ME. Macrocyclic ?-defensins suppress tumor necrosis factor-a (TNF-a) shedding by inhibition of TNF-a-converting enzyme. J Biol Chem. 2018 Feb 23; 293(8):2725-2734. PMID: 29317500.
      View in: PubMed
    3. Schaal JB, Tran DQ, Subramanian A, Patel R, Laragione T, Roberts KD, Trinh K, Tongaonkar P, Tran PA, Minond D, Fields GB, Beringer P, Ouellette AJ, Gulko PS, Selsted ME. Suppression and resolution of autoimmune arthritis by rhesus ?-defensin-1, an immunomodulatory macrocyclic peptide. PLoS One. 2017; 12(11):e0187868. PMID: 29145473.
      View in: PubMed
    4. Tongaonkar P, Trinh KK, Schaal JB, Tran D, Gulko PS, Ouellette AJ, Selsted ME. Rhesus macaque ?-defensin RTD-1 inhibits proinflammatory cytokine secretion and gene expression by inhibiting the activation of NF-?B and MAPK pathways. J Leukoc Biol. 2015 Dec; 98(6):1061-70. PMID: 26269197.
      View in: PubMed
    5. Schaal JB, Tran D, Tran P, Ösapay G, Trinh K, Roberts KD, Brasky KM, Tongaonkar P, Ouellette AJ, Selsted ME. Rhesus macaque theta defensins suppress inflammatory cytokines and enhance survival in mouse models of bacteremic sepsis. PLoS One. 2012; 7(12):e51337. PMID: 23236475; PMCID: PMC3516535.
    6. Tongaonkar P, Golji AE, Tran P, Ouellette AJ, Selsted ME. High fidelity processing and activation of the human a-defensin HNP1 precursor by neutrophil elastase and proteinase 3. PLoS One. 2012; 7(3):e32469. PMID: 22448222; PMCID: PMC3308943.
    7. Tongaonkar P, Tran P, Roberts K, Schaal J, Osapay G, Tran D, Ouellette AJ, Selsted ME. Rhesus macaque ?-defensin isoforms: expression, antimicrobial activities, and demonstration of a prominent role in neutrophil granule microbicidal activities. J Leukoc Biol. 2011 Feb; 89(2):283-90. PMID: 21084627; PMCID: PMC3024902.
    8. Tongaonkar P, Selsted ME. SDF2L1, a component of the endoplasmic reticulum chaperone complex, differentially interacts with {alpha}-, {beta}-, and {theta}-defensin propeptides. J Biol Chem. 2009 Feb 27; 284(9):5602-9. PMID: 19109254; PMCID: PMC2645818.
    9. Hontz RD, French SL, Oakes ML, Tongaonkar P, Nomura M, Beyer AL, Smith JS. Transcription of multiple yeast ribosomal DNA genes requires targeting of UAF to the promoter by Uaf30. Mol Cell Biol. 2008 Nov; 28(21):6709-19. PMID: 18765638; PMCID: PMC2573240.
    10. Tongaonkar P, French SL, Oakes ML, Vu L, Schneider DA, Beyer AL, Nomura M. Histones are required for transcription of yeast rRNA genes by RNA polymerase I. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10129-34. PMID: 16002464; PMCID: PMC1177414.
    11. Ortolan TG, Chen L, Tongaonkar P, Madura K. Rad23 stabilizes Rad4 from degradation by the Ub/proteasome pathway. Nucleic Acids Res. 2004; 32(22):6490-500. PMID: 15601997; PMCID: PMC545455.
    12. Kobayashi T, Horiuchi T, Tongaonkar P, Vu L, Nomura M. SIR2 regulates recombination between different rDNA repeats, but not recombination within individual rRNA genes in yeast. Cell. 2004 May 14; 117(4):441-53. PMID: 15137938.
      View in: PubMed
    13. Tongaonkar P, Dodd JA, Nomura M. Purification and assay of upstream activation factor, core factor, Rrn3p, and yeast RNA polymerase I. Methods Enzymol. 2003; 370:109-20. PMID: 14712638.
      View in: PubMed
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