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Jon A. Detterich, MD

Title(s)Associate Professor Of Clinical Pediatrics
Phone+1 323 361 5473
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    The Impact of Hemoglobin S on Red Blood Cell Nitric Oxide Production
    NIH/NHLBI R03HL138321Aug 11, 2017 - Jul 31, 2019
    Role: Principal Investigator
    Erythrocyte Nitric Oxide Links Rheology and Vasculopathy in Sickle Cell Disease
    NIH/NHLBI K23HL119627Aug 15, 2014 - Mar 31, 2017
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Detterich JA, Liu H, Suriany S, Kato RM, Chalacheva P, Tedla B, Shah PM, Khoo MC, Wood JC, Coates TD, Milne GL, Oh JY, Patel RP, Forman HJ. Erythrocyte and plasma oxidative stress appears to be compensated in patients with sickle cell disease during a period of relative health, despite the presence of known oxidative agents. Free Radic Biol Med. 2019 Jul 03. PMID: 31279092.
      View in: PubMed
    2. Detterich JA, Kato R, Bush A, Chalacheva P, Ponce D, De Zoysa M, Shah P, Khoo MC, Meiselman HJ, Coates TD, Wood JC. Sickle cell microvascular paradox-oxygen supply-demand mismatch. Am J Hematol. 2019 Jun; 94(6):678-688. PMID: 30916797.
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    3. Shah P, Khaleel M, Thuptimdang W, Sunwoo J, Veluswamy S, Chalacheva P, Kato RM, Detterich J, Wood JC, Zeltzer L, Sposto R, Khoo MCK, Coates TD. Mental stress causes vasoconstriction in sickle cell disease and normal controls. Haematologica. 2019 Apr 11. PMID: 30975906.
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    4. Chalacheva P, Kato RM, Shah P, Veluswamy S, Denton CC, Sunwoo J, Thuptimdang W, Wood JC, Detterich JA, Coates TD, Khoo MCK. Sickle Cell Disease Subjects Have a Distinct Abnormal Autonomic Phenotype Characterized by Peripheral Vasoconstriction With Blunted Cardiac Response to Head-Up Tilt. Front Physiol. 2019; 10:381. PMID: 31031633.
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    5. Cheng AL, Kaslow AM, Pruetz JD, Lu JC, Wood JC, Detterich JA. Differences in Right Ventricular Physiologic Response to Chronic Volume Load in Patients with Repaired Pulmonary Atresia Intact Ventricular Septum/Critical Pulmonary Stenosis Versus Tetralogy of Fallot. Pediatr Cardiol. 2019 Mar; 40(3):526-536. PMID: 30353312.
      View in: PubMed
    6. Simmonds MJ, Suriany S, Ponce D, Detterich JA. Red blood cell mechanical sensitivity improves in patients with sickle cell disease undergoing chronic transfusion after prolonged, subhemolytic shear exposure. Transfusion. 2018 12; 58(12):2788-2796. PMID: 30325033.
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    7. Sunwoo J, Chalacheva P, Khaleel M, Shah P, Sposto R, Kato RM, Detterich J, Zeltzer LK, Wood JC, Coates TD, Khoo MC. A novel cross-correlation methodology for assessing biophysical responses associated with pain. J Pain Res. 2018; 11:2207-2219. PMID: 30323655.
      View in: PubMed
    8. Armenian SH, Rinderknecht D, Au K, Lindenfeld L, Mills G, Siyahian A, Herrera C, Wilson K, Venkataraman K, Mascarenhas K, Tavallali P, Razavi M, Pahlevan N, Detterich J, Bhatia S, Gharib M. Accuracy of a Novel Handheld Wireless Platform for Detection of Cardiac Dysfunction in Anthracycline-Exposed Survivors of Childhood Cancer. Clin Cancer Res. 2018 07 01; 24(13):3119-3125. PMID: 29929955.
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    9. Detterich JA. Simple chronic transfusion therapy, a crucial therapeutic option for sickle cell disease, improves but does not normalize blood rheology: What should be our goals for transfusion therapy? Clin Hemorheol Microcirc. 2018; 68(2-3):173-186. PMID: 29614631.
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    10. Khaleel M, Puliyel M, Shah P, Sunwoo J, Kato RM, Chalacheva P, Thuptimdang W, Detterich J, Wood JC, Tsao J, Zeltzer L, Sposto R, Khoo MCK, Coates TD. Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain. Am J Hematol. 2017 Nov; 92(11):1137-1145. PMID: 28707371.
      View in: PubMed
    11. Detterich JA. Myocardial fibrosis: the heart of diastole? Blood. 2017 07 13; 130(2):104-105. PMID: 28705857.
      View in: PubMed
    12. Chalacheva P, Khaleel M, Sunwoo J, Shah P, Detterich JA, Kato RM, Thuptimdang W, Meiselman HJ, Sposto R, Tsao J, Wood JC, Zeltzer L, Coates TD, Khoo MCK. Biophysical markers of the peripheral vasoconstriction response to pain in sickle cell disease. PLoS One. 2017; 12(5):e0178353. PMID: 28542469.
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    13. Cheng AL, Takao CM, Wenby RB, Meiselman HJ, Wood JC, Detterich JA. Elevated Low-Shear Blood Viscosity is Associated with Decreased Pulmonary Blood Flow in Children with Univentricular Heart Defects. Pediatr Cardiol. 2016 Apr; 37(4):789-801. PMID: 26888364.
      View in: PubMed
    14. Connes P, Alexy T, Detterich J, Romana M, Hardy-Dessources MD, Ballas SK. The role of blood rheology in sickle cell disease. Blood Rev. 2016 Mar; 30(2):111-8. PMID: 26341565.
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    15. Shashidharan S, Wells WJ, Detterich J, Wong J, Kumar SR. Giant Pseudoaneurysm of Reconstructed Right Ventricular Outflow Tract. Ann Thorac Surg. 2015 Aug; 100(2):734. PMID: 26234857.
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    16. Chalacheva P, Kato RM, Sangkatumvong S, Detterich J, Bush A, Wood JC, Meiselman H, Coates TD, Khoo MC. Autonomic responses to cold face stimulation in sickle cell disease: a time-varying model analysis. Physiol Rep. 2015 Jul 14; 3(7). PMID: 26177958.
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    17. Detterich JA, Kato RM, Rabai M, Meiselman HJ, Coates TD, Wood JC. Chronic transfusion therapy improves but does not normalize systemic and pulmonary vasculopathy in sickle cell disease. Blood. 2015 Aug 06; 126(6):703-10. PMID: 26036801.
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    18. Meloni A, Detterich J, Pepe A, Harmatz P, Coates TD, Wood JC. Pulmonary hypertension in well-transfused thalassemia major patients. Blood Cells Mol Dis. 2015 Feb; 54(2):189-94. PMID: 25488617.
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    19. Pruetz JD, Carroll C, Trento LU, Chang RK, Detterich J, Miller DA, Sklansky M. Outcomes of critical congenital heart disease requiring emergent neonatal cardiac intervention. Prenat Diagn. 2014 Dec; 34(12):1127-32. PMID: 24947130.
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    20. Simmonds MJ, Detterich JA, Connes P. Nitric oxide, vasodilation and the red blood cell. Biorheology. 2014; 51(2-3):121-34. PMID: 24819865.
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    21. Rabai M, Detterich JA, Wenby RB, Toth K, Meiselman HJ. Effects of ethanol on red blood cell rheological behavior. Clin Hemorheol Microcirc. 2014; 56(2):87-99. PMID: 23089886.
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    22. Rabai M, Detterich JA, Wenby RB, Hernandez TM, Toth K, Meiselman HJ, Wood JC. Deformability analysis of sickle blood using ektacytometry. Biorheology. 2014; 51(2-3):159-70. PMID: 24898336.
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    23. Paquette LB, Wisnowski JL, Ceschin R, Pruetz JD, Detterich JA, Del Castillo S, Nagasunder AC, Kim R, Painter MJ, Gilles FH, Nelson MD, Williams RG, Bl├╝ml S, Panigrahy A. Abnormal cerebral microstructure in premature neonates with congenital heart disease. AJNR Am J Neuroradiol. 2013 Oct; 34(10):2026-33. PMID: 23703146.
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    24. Meloni A, Detterich J, Berdoukas V, Pepe A, Lombardi M, Coates TD, Wood JC. Comparison of biventricular dimensions and function between pediatric sickle-cell disease and thalassemia major patients without cardiac iron. Am J Hematol. 2013 Mar; 88(3):213-8. PMID: 23386313.
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    25. Detterich JA, Sangkatumvong S, Kato R, Dongelyan A, Bush A, Khoo M, Meiselman HJ, Coates TD, Wood JC. Patients with sickle cell anemia on simple chronic transfusion protocol show sex differences for hemodynamic and hematologic responses to transfusion. Transfusion. 2013 May; 53(5):1059-68. PMID: 23176402.
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    26. Trento LU, Pruetz JD, Chang RK, Detterich J, Sklansky MS. Prenatal diagnosis of congenital heart disease: impact of mode of delivery on neonatal outcome. Prenat Diagn. 2012 Dec; 32(13):1250-5. PMID: 23080120.
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    27. Detterich JA, Pruetz J, Sklansky MS. Color M-mode sonography for evaluation of fetal arrhythmias. J Ultrasound Med. 2012 Oct; 31(10):1681-8. PMID: 23011632.
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    28. Detterich J, Alexy T, Rabai M, Wenby R, Dongelyan A, Coates T, Wood J, Meiselman H. Low-shear red blood cell oxygen transport effectiveness is adversely affected by transfusion and further worsened by deoxygenation in sickle cell disease patients on chronic transfusion therapy. Transfusion. 2013 Feb; 53(2):297-305. PMID: 22882132.
      View in: PubMed
    29. Friedman D, Szmuszkovicz J, Rabai M, Detterich JA, Menteer J, Wood JC. Systemic endothelial dysfunction in children with idiopathic pulmonary arterial hypertension correlates with disease severity. J Heart Lung Transplant. 2012 Jun; 31(6):642-7. PMID: 22440720.
      View in: PubMed
    30. Rabai M, Meiselman HJ, Wenby RB, Detterich JA, Feinberg J. Analysis of light scattering by red blood cells in ektacytometry using global pattern fitting. Biorheology. 2012; 49(5-6):317-28. PMID: 23380898.
      View in: PubMed
    31. Jones K, Tierney K, Grubbs BH, Pruetz JD, Detterich J, Chmait RH. Fetoscopic laser photocoagulation of feeding vessels to a large placental chorioangioma following fetal deterioration after amnioreduction. Fetal Diagn Ther. 2012; 31(3):191-5. PMID: 22086270.
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    32. Detterich J, Noetzli L, Dorey F, Bar-Cohen Y, Harmatz P, Coates T, Wood J. Electrocardiographic consequences of cardiac iron overload in thalassemia major. Am J Hematol. 2012 Feb; 87(2):139-44. PMID: 22052662.
      View in: PubMed
    33. Sangkatumvong S, Khoo MC, Kato R, Detterich JA, Bush A, Keens TG, Meiselman HJ, Wood JC, Coates TD. Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia in sickle cell disease. Am J Respir Crit Care Med. 2011 Aug 15; 184(4):474-81. PMID: 21616995.
      View in: PubMed
    34. Pruetz JD, Sklansky M, Detterich J, Korst LM, Llanes A, Chmait RH. Twin-twin transfusion syndrome treated with laser surgery: postnatal prevalence of congenital heart disease in surviving recipients and donors. Prenat Diagn. 2011 Oct; 31(10):973-7. PMID: 21744364.
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    35. Pruetz J, Detterich J, Trento L, Sklansky M. Prenatal diagnosis of cor triatriatum sinister in association with hypoplastic left heart syndrome. Pediatr Cardiol. 2011 Aug; 32(6):818-21. PMID: 21359947.
      View in: PubMed
    36. Sangkatumvong S, Coates TD, Wood JC, Meiselman HJ, Kato R, Detterich JA, Bush A, Khoo MC. Time-varying analysis of autonomic control in response to spontaneous sighs in sickle cell anemia. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:1626-9. PMID: 21096136.
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