Michael Chee-Kuan Khoo, PhD

SchoolViterbi School of Engineering, BME
Phone+1 213 740 0347
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    Michael C.K. Khoo received his BSc(Eng) degree in Mechanical Engineering from the Imperial College of Science and Technology, University of London, in 1976, and the M.S. and Ph.D. degrees in Biomedical Engineering from Harvard University in 1977 and 1981, respectively. Before joining the faculty at USC in 1983, Dr. Khoo worked as a research engineer on a collaborative project involving the Veterans Administration Medical Center (West Roxbury), Brigham and Women's Hospital (Boston) and the Massachusetts Institute of Technology. Dr. Khoo has been the recipient of a Research Career Development Award from the National Institutes of Health and a Career Investigator Award from the American Lung Association. He is principal investigator of one of the Core Projects in the Biomedical Simulations Resource, a national center funded by the NIH National Institute of Biomedical Imaging and Bioengineering, dedicated to advancing the state of the art in biomedical modeling and computer simulation. He is also the co-principal investigator of an NIH training grant in Biomedical Imaging Informatics, and co-Director of Education and Outreach for the NSF-funded Engineering Research Center on Biomimetic Microelectronic Systems. Dr. Khoo is a Fellow of the American Institute of Medical and Biological Engineering (AIMBE) and the Biomedical Engineering Society (BMES). He was BME Department Chair 2003-2010.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    2. Chalacheva P, Kato RM, Shah P, Veluswamy S, Denton CC, Sunwoo J, Thuptimdang W, Wood JC, Detterich JA, Coates TD, Khoo MCK. Sickle Cell Disease Subjects Have a Distinct Abnormal Autonomic Phenotype Characterized by Peripheral Vasoconstriction With Blunted Cardiac Response to Head-Up Tilt. Front Physiol. 2019; 10:381. PMID: 31031633.
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    3. Nava-Guerra L, Edwards BA, Terrill PI, Sands SA, Amin RS, Kemp JS, Khoo MCK. Quantifying ventilatory control stability from spontaneous sigh responses during sleep: a comparison of two approaches. Physiol Meas. 2018 11 22; 39(11):114005. PMID: 30465721.
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    4. Coates TD, Chalacheva P, Zeltzer L, Khoo MCK. Autonomic nervous system involvement in sickle cell disease. Clin Hemorheol Microcirc. 2018; 68(2-3):251-262. PMID: 29614636.
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    5. Chalacheva P, Khaleel M, Sunwoo J, Shah P, Detterich JA, Kato RM, Thuptimdang W, Meiselman HJ, Sposto R, Tsao J, Wood JC, Zeltzer L, Coates TD, Khoo MCK. Biophysical markers of the peripheral vasoconstriction response to pain in sickle cell disease. PLoS One. 2017; 12(5):e0178353. PMID: 28542469.
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    6. Khoo MCK, Chalacheva P. Model-Derived Markers of Autonomic Cardiovascular Dysfunction in Sleep-Disordered Breathing. Sleep Med Clin. 2016 Dec; 11(4):489-501. PMID: 28118872.
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    7. Nava-Guerra L, Tran WH, Chalacheva P, Loloyan S, Joshi B, Keens TG, Nayak KS, Davidson Ward SL, Khoo MC. Model-based stability assessment of ventilatory control in overweight adolescents with obstructive sleep apnea during NREM sleep. J Appl Physiol (1985). 2016 07 01; 121(1):185-97. PMID: 27174926.
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    8. Khoo MC, Blasi A. Sleep-related changes in autonomic control in obstructive sleep apnea: a model-based perspective. Respir Physiol Neurobiol. 2013 Sep 15; 188(3):267-76. PMID: 23707878; PMCID: PMC3778082.
    9. Khoo MC, Oliveira FM, Cheng L. Understanding the metabolic syndrome: a modeling perspective. IEEE Rev Biomed Eng. 2013; 6:143-55. PMID: 23232440; PMCID: PMC4153831.
    10. Cheng L, Khoo MC. Modeling the autonomic and metabolic effects of obstructive sleep apnea: a simulation study. Front Physiol. 2011; 2:111. PMID: 22291654; PMCID: PMC3250672.
    11. Cheng L, Ivanova O, Fan HH, Khoo MC. An integrative model of respiratory and cardiovascular control in sleep-disordered breathing. Respir Physiol Neurobiol. 2010 Nov 30; 174(1-2):4-28. PMID: 20542148; PMCID: PMC2965826.
    12. Khoo MC. Modeling of autonomic control in sleep-disordered breathing. Cardiovasc Eng. 2008 Mar; 8(1):30-41. PMID: 18060581; PMCID: PMC3339254.
    13. Belozeroff V, Berry RB, Sassoon CS, Khoo MC. Effects of CPAP therapy on cardiovascular variability in obstructive sleep apnea: a closed-loop analysis. Am J Physiol Heart Circ Physiol. 2002 Jan; 282(1):H110-21. PMID: 11748054.
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    14. Khoo MC, Belozeroff V, Berry RB, Sassoon CS. Cardiac autonomic control in obstructive sleep apnea: effects of long-term CPAP therapy. Am J Respir Crit Care Med. 2001 Sep 01; 164(5):807-12. PMID: 11549537.
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    15. Khoo MC. Determinants of ventilatory instability and variability. Respir Physiol. 2000 Sep; 122(2-3):167-82. PMID: 10967342.
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