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CD33-CD123 IF-THEN gating reduces toxicity while enhancing the specificity and memory phenotype of AML-targeting CAR-T cells. Blood Cancer Discov. 2024 Dec 03.
Jambon S, Sun J, Barman S, Muthugounder S, Bito XR, Shadfar A, Kovach AE, Wood BL, Thoppey Manoharan V, Morrissy AS, Bhojwani D, Wayne AS, Pulsipher MA, Kim YM, Asgharzadeh S, Parekh C, Moghimi B. PMID: 39624992.
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Genomic landscape of testicular follicular lymphoma is characterized by frequent 1p36/TNFRSF14 alterations. Blood Adv. 2024 Nov 27.
Zhang W, Perry AM, Hamnvåg HM, Kitahara S, Ondrejka SL, Kovach AE, Yuan JJ, Chew K, Davidson JH, Bedell V, Stokke J, Song JY. PMID: 39602674.
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CRLF2-rearranged B-cell ALL with extramedullary lineage switch to AML following CD19-targeted therapy. J Immunother Cancer. 2024 Oct 26; 12(10).
Silbert SK, Scanlon S, Wang HW, Yuan CM, Doverte A, Wellek J, Patel N, Braylan R, Ahlman M, Turkbey EB, Bohling SD, Chisholm KM, Oztek MA, LaLoggia M, Verma A, Shalabi H, Kovach AE, Wood BL, Lamble A, Kirsch I, Leger K, Shah NN. PMID: 39461880; PMCID: PMC11529463.
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Humans
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Nivolumab+AVD in Advanced-Stage Classic Hodgkin's Lymphoma. N Engl J Med. 2024 Oct 17; 391(15):1379-1389.
Herrera AF, LeBlanc M, Castellino SM, Li H, Rutherford SC, Evens AM, Davison K, Punnett A, Parsons SK, Ahmed S, Casulo C, Bartlett NL, Tuscano JM, Mei MG, Hess BT, Jacobs R, Saeed H, Torka P, Hu B, Moskowitz C, Kaur S, Goyal G, Forlenza C, Doan A, Lamble A, Kumar P, Chowdhury S, Brinker B, Sharma N, Singh A, Blum KA, Perry AM, Kovach A, Hodgson D, Constine LS, Shields LK, Prica A, Dillon H, Little RF, Shipp MA, Crump M, Kahl B, Leonard JP, Smith SM, Song JY, Kelly KM, Friedberg JW. PMID: 39413375; PMCID: PMC11488644.
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HumansCTClinical Trials
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Pediatric therapy-related hematologic neoplasms show enrichment for KMT2A rearrangement and lymphoblastic phenotype. Leuk Lymphoma. 2024 Aug 08; 1-13.
Kovach AE, Komova D, Itov A, Gaskova M, Kalinina I, Voronin K, Rumiantseva Y, Karachunskii A, Maschan M, Maschan A, Novichkova G, Olshanskaya Y, Bhojwani D, Raca G, Zerkalenkova E. PMID: 39116419.
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Humans
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Significant Variability in the Identification and Reporting of Band Neutrophils by Participants Enrolled in the College of American Pathologists Proficiency Testing Program: Time for a Change. Arch Pathol Lab Med. 2024 Jun 01; 148(6):666-676.
Vergara-Lluri M, Kovach AE, Nakashima MO, Bradley KT, Mahe E, Tsao L, Savage NM, Salansky SA, Long T, Perkins SL, Hsi ED, Pozdnyakova O, Bhargava P. PMID: 37638547.
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HumansCells
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Development of second genetically distinct T-lymphoblastic leukemia in a pediatric patient. Pediatr Blood Cancer. 2024 Aug; 71(8):e31050.
Hultquist H, Rodriguez A, Ferreira JE, Placek A, Miller KP, Wood BL, Bhojwani D, Kapoor N, Raca G, Gaynon P, Kovach AE. PMID: 38736199; PMCID: PMC11208117.
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Humans
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A de novo germline RUNX1 variant preceding development of concurrent T-lymphoblastic leukemia and myelodysplastic syndrome. Leuk Lymphoma. 2024 Sep; 65(9):1357-1361.
Wang CP, Ferreira JE, Placek A, Aguayo-Hiraldo P, Raca G, Wood BL, Miller KP, Coates T, Freyer DR, Kovach AE. PMID: 38733629.
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Humans
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B-cell acute lymphoblastic leukemia and juvenile xanthogranuloma in a patient with ETV6 thrombocytopenia and leukemia predisposition syndrome: novel clinical presentation and perspective. Haematologica. 2024 05 01; 109(5):1624-1627.
Newman H, MacFarland SP, Brodeur GM, Olson T, Bhojwani D, Stokke J, Kovach AE, Clark ME, Luo M, Li M, Shah A, Hunger SP. PMID: 38031764; PMCID: PMC11063871.
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Humans
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IKZF1PLUS alterations contribute to outcome disparities in Hispanic/Latino children with B-lymphoblastic leukemia. Pediatr Blood Cancer. 2024 Jul; 71(7):e30996.
Kovach AE, Wengyn M, Vu MH, Doan A, Raca G, Bhojwani D. PMID: 38637852; PMCID: PMC11193948.
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Humans
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Maturational dyssynchrony in benign B-cell precursors following lymphocyte depleting chemotherapy: A potential pitfall for B-lymphoblastic leukemia minimal/measurable residual disease (MRD) flow cytometry analysis. Cytometry B Clin Cytom. 2024 03; 106(2):138-141.
Placek A, Lockhart B, Miller KP, Wertheim GB, Maude SL, Wood BL, Kovach AE. PMID: 38247200.
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HumansCells
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Outcomes of patients with blastoid and pleomorphic variant mantle cell lymphoma. Blood Adv. 2023 12 26; 7(24):7393-7401.
Gerson JN, Handorf E, Villa D, Gerrie AS, Chapani P, Li S, Medeiros LJ, Wang M, Cohen JB, Churnetski M, Hill BT, Sawalha Y, Hernandez-Ilizaliturri FJ, Kothari S, Vose JM, Bast M, Fenske T, Rao Gari SN, Maddocks KJ, Bond D, Bachanova V, Kolla B, Chavez J, Shah B, Lansigan F, Burns T, Donovan AM, Wagner-Johnston N, Messmer M, Mehta A, Anderson JK, Reddy N, Kovach AE, Landsburg DJ, Glenn M, Inwards DJ, Ristow K, Karmali R, Kaplan JB, Caimi PF, Rajguru S, Evens A, Klein A, Umyarova E, Pulluri B, Amengual JE, Lue JK, Diefenbach C, Fisher RI, Barta SK. PMID: 37874912; PMCID: PMC10758713.
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4 Fields:
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Humans
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An Exome Capture-Based RNA-Sequencing Assay for Genome-Wide Identification and Prioritization of Clinically Important Fusions in Pediatric Tumors. J Mol Diagn. 2024 02; 26(2):127-139.
Buckley J, Schmidt RJ, Ostrow D, Maglinte D, Bootwalla M, Ruble D, Govindarajan A, Ji J, Kovach AE, Orgel E, Raca G, Navid F, Mascarenhas L, Pawel B, Robison N, Gai X, Biegel JA. PMID: 38008288.
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1 Fields:
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Humans
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Concordance of Next-Generation Sequencing and Multiparametric Flow Cytometry Methods for Detecting Measurable Residual Disease in Adult Acute Lymphoblastic Leukemia: Optimizing Prediction of Clinical Outcomes From a Single-Center Study. Clin Lymphoma Myeloma Leuk. 2024 03; 24(3):e59-e66.e2.
Ashouri K, Nittur V, Ginosyan AA, Hwang J, Adnani B, Chen D, Savitala-Damerla L, Schiff K, Chaudhary P, Kovach AE, Ladha A, Siddiqi I, Ali A, Woan K, Tam E, Yaghmour G. PMID: 38061959.
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Humans
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Transcriptome Sequencing Allows Comprehensive Genomic Characterization of Pediatric B-Acute Lymphoblastic Leukemia in an Academic Clinical Laboratory. J Mol Diagn. 2024 01; 26(1):49-60.
Hu Z, Kovach AE, Yellapantula V, Ostrow D, Doan A, Ji J, Schmidt RJ, Gu Z, Bhojwani D, Raca G. PMID: 37981088; PMCID: PMC10773144.
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1 Fields:
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HumansCells
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Updates on lymphoblastic leukemia/lymphoma classification and minimal/measurable residual disease analysis. Semin Diagn Pathol. 2023 Nov; 40(6):457-471.
Kovach AE, Wood BL. PMID: 37953192.
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Humans
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Correction: "The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms" Leukemia. 2022 Jul;36(7):1720-1748. Leukemia. 2023 Sep; 37(9):1944-1951.
Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, de Oliveira Araujo IB, Berti E, Bhagat G, Borges AM, Boyer D, Calaminici M, Chadburn A, Chan JKC, Cheuk W, Chng WJ, Choi JK, Chuang SS, Coupland SE, Czader M, Dave SS, de Jong D, Di Napoli A, Du MQ, Elenitoba-Johnson KS, Ferry J, Geyer J, Gratzinger D, Guitart J, Gujral S, Harris M, Harrison CJ, Hartmann S, Hochhaus A, Jansen PM, Karube K, Kempf W, Khoury J, Kimura H, Klapper W, Kovach AE, Kumar S, Lazar AJ, Lazzi S, Leoncini L, Leung N, Leventaki V, Li XQ, Lim MS, Liu WP, Louissaint A, Marcogliese A, Medeiros LJ, Michal M, Miranda RN, Mitteldorf C, Montes-Moreno S, Morice W, Nardi V, Naresh KN, Natkunam Y, Ng SB, Oschlies I, Ott G, Parrens M, Pulitzer M, Rajkumar SV, Rawstron AC, Rech K, Rosenwald A, Said J, Sarkozy C, Sayed S, Saygin C, Schuh A, Sewell W, Siebert R, Sohani AR, Suzuki R, Tooze R, Traverse-Glehen A, Vega F, Vergier B, Wechalekar AD, Wood B, Xerri L, Xiao W, International Agency for Research on Cancer/World Health Organization. PMID: 37468552; PMCID: PMC10457187.
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2 Fields:
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Efficacy and safety of FLAG-IDA as front-line therapy in de novo paediatric acute myeloid leukaemia population. Br J Haematol. 2023 07; 202(1):e3-e6.
Doan A, Huang HKT, Hadar AJ, Malvar J, Rushing T, Raca G, Kovach AE, Freyer DR, Parekh C, Stokke J, Posch LC, Dao J, Bhojwani D, Gaynon P, Orgel E. PMID: 37129267; PMCID: PMC10330637.
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Humans
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Molecular Evolution of Classic Hodgkin Lymphoma Revealed Through Whole-Genome Sequencing of Hodgkin and Reed Sternberg Cells. Blood Cancer Discov. 2023 05 01; 4(3):208-227.
Maura F, Ziccheddu B, Xiang JZ, Bhinder B, Rosiene J, Abascal F, Maclachlan KH, Eng KW, Uppal M, He F, Zhang W, Gao Q, Yellapantula VD, Trujillo-Alonso V, Park SI, Oberley MJ, Ruckdeschel E, Lim MS, Wertheim GB, Barth MJ, Horton TM, Derkach A, Kovach AE, Forlenza CJ, Zhang Y, Landgren O, Moskowitz CH, Cesarman E, Imielinski M, Elemento O, Roshal M, Giulino-Roth L. PMID: 36723991; PMCID: PMC10150291.
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11 Fields:
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HumansCells
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Modern Classification and Management of Pediatric B-cell Leukemia and Lymphoma. Surg Pathol Clin. 2023 Jun; 16(2):249-266.
Kovach AE, Raca G. PMID: 37149359.
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Humans
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Preinfusion factors impacting relapse immunophenotype following CD19 CAR T cells. Blood Adv. 2023 02 28; 7(4):575-585.
Lamble AJ, Myers RM, Taraseviciute A, John S, Yates B, Steinberg SM, Sheppard J, Kovach AE, Wood B, Borowitz MJ, Stetler-Stevenson M, Yuan CM, Pillai V, Foley T, Chung P, Chen L, Lee DW, Annesley C, DiNofia A, Grupp SA, Verneris MR, Gore L, Laetsch TW, Bhojwani D, Brown PA, Pulsipher MA, Rheingold SR, Gardner RA, Shah NN. PMID: 35482927; PMCID: PMC9979750.
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41 Fields:
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AnimalsCells
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Spontaneous remission of acute lymphoblastic leukemia: A series of nine cases and a review of literature. Int J Lab Hematol. 2023 Aug; 45(4):489-495.
Kirtek T, Hamdan H, Van Arnam JS, Park S, Kovach AE, Pillai V, Weinberg OK. PMID: 36806637.
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2 Fields:
Translation:
Humans
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The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms. Leukemia. 2022 07; 36(7):1720-1748.
Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IBO, Berti E, Bhagat G, Borges AM, Boyer D, Calaminici M, Chadburn A, Chan JKC, Cheuk W, Chng WJ, Choi JK, Chuang SS, Coupland SE, Czader M, Dave SS, de Jong D, Du MQ, Elenitoba-Johnson KS, Ferry J, Geyer J, Gratzinger D, Guitart J, Gujral S, Harris M, Harrison CJ, Hartmann S, Hochhaus A, Jansen PM, Karube K, Kempf W, Khoury J, Kimura H, Klapper W, Kovach AE, Kumar S, Lazar AJ, Lazzi S, Leoncini L, Leung N, Leventaki V, Li XQ, Lim MS, Liu WP, Louissaint A, Marcogliese A, Medeiros LJ, Michal M, Miranda RN, Mitteldorf C, Montes-Moreno S, Morice W, Nardi V, Naresh KN, Natkunam Y, Ng SB, Oschlies I, Ott G, Parrens M, Pulitzer M, Rajkumar SV, Rawstron AC, Rech K, Rosenwald A, Said J, Sarkozy C, Sayed S, Saygin C, Schuh A, Sewell W, Siebert R, Sohani AR, Tooze R, Traverse-Glehen A, Vega F, Vergier B, Wechalekar AD, Wood B, Xerri L, Xiao W. PMID: 35732829; PMCID: PMC9214472.
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842 Fields:
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Humans
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Characterization of PAX5 intragenic tandem multiplication in pediatric B-lymphoblastic leukemia by optical genome mapping. Blood Adv. 2022 06 14; 6(11):3343-3346.
Jean J, Kovach AE, Doan A, Oberley M, Ji J, Schmidt RJ, Biegel JA, Bhojwani D, Raca G. PMID: 35245931; PMCID: PMC9198916.
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3 Fields:
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Humans
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Survival of pediatric Hodgkin lymphoma patients treated with doxorubicin, bleomycin, vincristine, etoposide, prednisone, and cyclophosphamide (ABVE-PC) versus doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) at a single institution. Pediatr Blood Cancer. 2022 05; 69(5):e29601.
de Armas S, Huertas-Ayala C, Chan RY, Chi YY, Huh WW, Termuhlen A, Gaynon PS, Kovach AE, Doan A. PMID: 35187850; PMCID: PMC10257525.
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Humans
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Acute myeloid leukemia with t(X;6)9p11;q23);MYB-GATA1 and female sex: GATA1 insufficiency may be insufficient for pathogenesis. Cancer Genet. 2022 01; 260-261:37-40.
Kovach AE, Zerkalenkova E, Zemtsova L, Borkovskaya A, Gaskova M, Kazanov M, Popov A, Baidun L, Maschan M, Maschan A, Gaynon PS, Bhojwani D, Novichkova G, Olshanskaya Y, Raca G. PMID: 34915342.
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1 Fields:
Translation:
HumansCells
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Blinatumomab Nonresponse and High-Disease Burden Are Associated With Inferior Outcomes After CD19-CAR for B-ALL. J Clin Oncol. 2022 03 20; 40(9):932-944.
Myers RM, Taraseviciute A, Steinberg SM, Lamble AJ, Sheppard J, Yates B, Kovach AE, Wood B, Borowitz MJ, Stetler-Stevenson M, Yuan CM, Pillai V, Foley T, Chung P, Chen L, Lee DW, Annesley C, DiNofia A, Grupp SA, John S, Bhojwani D, Brown PA, Laetsch TW, Gore L, Gardner RA, Rheingold SR, Pulsipher MA, Shah NN. PMID: 34767461; PMCID: PMC8937010.
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72 Fields:
Translation:
Humans
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Pediatric hematolymphoid pathology in the gastrointestinal tract. Semin Diagn Pathol. 2021 Jul; 38(4):31-37.
Mason EF, Hossein-Zadeh Z, Kovach AE. PMID: 33863576.
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Humans
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BCR-ABL1-like B-Lymphoblastic Leukemia/Lymphoma with FOXP1-ABL1 Rearrangement: Comprehensive Laboratory Identification Allowing Tyrosine Kinase Inhibitor Use. Lab Med. 2019 Oct 10; 50(4):401-405.
Yenamandra AK, Kaviany S, Borinstein SC, Friedman DL, Kovach AE. PMID: 30938769.
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2 Fields:
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Humans
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Molecular and Cytogenetic Education in Hematopathology Fellowship. Am J Clin Pathol. 2019 09 09; 152(4):438-445.
Soma LA, Kovach AE, Siddon AJ, Beck R, Gibson SE, Swerdlow SH, Kim AS, Wu D, Jones D, Cook JR, Prakash S, Rosado F, Crane G, Bradley K, Weinberg OK, Sargent RL. PMID: 31141139.
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Ectopic Fetal Hepatic Tissue in the Placenta. Int J Gynecol Pathol. 2019 Sep; 38(5):426-429.
Stonko DP, Liang J, Weeks AG, Redline RW, Boyd TK, Watkins JC, Kovach AE. PMID: 29901524.
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2 Fields:
Translation:
Humans
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R-CHOP versus dose-adjusted R-EPOCH in frontline management of primary mediastinal B-cell lymphoma: a multi-centre analysis. Br J Haematol. 2018 02; 180(4):534-544.
Shah NN, Szabo A, Huntington SF, Epperla N, Reddy N, Ganguly S, Vose J, Obiozor C, Faruqi F, Kovach AE, Costa LJ, Xavier AC, Okal R, Kanate AS, Ghosh N, Kharfan-Dabaja MA, Strelec L, Hamadani M, Fenske TS, Calzada O, Cohen JB, Chavez J, Svoboda J. PMID: 29265182.
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44 Fields:
Translation:
Humans
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Fibrin-associated EBV-positive Large B-Cell Lymphoma: An Indolent Neoplasm With Features Distinct From Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation. Am J Surg Pathol. 2017 Mar; 41(3):299-312.
Boyer DF, McKelvie PA, de Leval L, Edlefsen KL, Ko YH, Aberman ZA, Kovach AE, Masih A, Nishino HT, Weiss LM, Meeker AK, Nardi V, Palisoc M, Shao L, Pittaluga S, Ferry JA, Harris NL, Sohani AR. PMID: 28195879.
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38 Fields:
Translation:
Humans
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Diffuse large B-cell lymphoma with concurrent high MYC and BCL2 expression shows evidence of active B-cell receptor signaling by quantitative immunofluorescence. PLoS One. 2017; 12(2):e0172364.
Bogusz AM, Kovach AE, Le LP, Feng D, Baxter RH, Sohani AR. PMID: 28212447; PMCID: PMC5315400.
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8 Fields:
Translation:
HumansCells
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Prognostic Significance of Residual Acute Myeloid Leukemia in Bone Marrow Samples Taken Prior to Allogeneic Hematopoietic Cell Transplantation. Am J Clin Pathol. 2017 Jan 01; 147(1):50-59.
Kovach AE, Brunner AM, Fathi AT, Chen YB, Hasserjian RP. PMID: 28108471.
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High rate of unnecessary thymectomy and its cause. Can computed tomography distinguish thymoma, lymphoma, thymic hyperplasia, and thymic cysts? Eur J Radiol. 2015 Mar; 84(3):524-533.
Ackman JB, Verzosa S, Kovach AE, Louissaint A, Lanuti M, Wright CD, Shepard JO, Halpern EF. PMID: 25575742.
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PubMed Mentions:
54 Fields:
Translation:
Humans
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Molecular classification of MYC-driven B-cell lymphomas by targeted gene expression profiling of fixed biopsy specimens. J Mol Diagn. 2015 Jan; 17(1):19-30.
Carey CD, Gusenleitner D, Chapuy B, Kovach AE, Kluk MJ, Sun HH, Crossland RE, Bacon CM, Rand V, Dal Cin P, Le LP, Neuberg D, Sohani AR, Shipp MA, Monti S, Rodig SJ. PMID: 25468432; PMCID: PMC4279427.
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PubMed Mentions:
11 Fields:
Translation:
Humans