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Natasha Lepore, PhD

TitleAssociate Professor of Research Radiology
InstitutionUniversity of Southern California
DepartmentPediatrics
AddressCHL Mail Stop 81
Off Campus
Los Angeles CA 90089
Phone+1 310 909 3296
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    My current work involves the development of numerical tools for the analysis of brain structural and diffusion magnetic resonance imaging data. In particular, these include improvements to tensor-based morphometry, surface and volume registration, segmentation and statistics for group comparisons. I also work on applying these methods to different types of brain imaging data including prematurity, healthy brain development, healthy twins, blindness, deafness, HIV/AIDS, autism and Alzheimer's disease. I am currently an assistant professor in Radiology at the University of Southern California and at Children's Hospital Los Angeles. I graduated with a Bsc in physics and mathematics from the University of Montreal and then obtained a masters in applied mathematics from Cambridge University, in general relativity. My PhD is in theoretical physics (Harvard University), and deals with quantum chaos in quantum billiards living on the plane and the pseudosphere. Afterward, I switched to neuroimaging and became a postdoctoral fellow at the Laboratory of Neuro Imaging, working with Dr Paul Thompson.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Poonai N, Datoo N, Ali S, Cashin M, Drendel AL, Zhu R, Lepore N, Greff M, Rieder M, Bartley D. Oral morphine versus ibuprofen administered at home for postoperative orthopedic pain in children: a randomized controlled trial. CMAJ. 2017 Oct 10; 189(40):E1252-E1258. PMID: 29018084.
      View in: PubMed
    2. Coloigner J, Kim Y, Bush A, Choi S, Balderrama MC, Coates TD, O'Neil SH, Lepore N, Wood JC. Contrasting resting-state fMRI abnormalities from sickle and non-sickle anemia. PLoS One. 2017; 12(10):e0184860. PMID: 28981541.
      View in: PubMed
    3. Coloigner J, Phlypo R, Coates TD, Lepore N, Wood JC. Graph Lasso-Based Test for Evaluating Functional Brain Connectivity in Sickle Cell Disease. Brain Connect. 2017 Sep; 7(7):443-453. PMID: 28747064.
      View in: PubMed
    4. Vlasova R, Dirks H, Dean D, O'Muircheartaigh J, Gonzalez S, Nelson MD, Deoni S, Lepore N. Contribution to speech development of the right anterior putamen revealed with multivariate tensor-based morphometry. Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:3085-3087. PMID: 29060550.
      View in: PubMed
    5. James C, Lepore F, Collignon O, Gajawelli N, Lepore N, Coulon O. Central sulcus depth and sulcal profile differences between congenitally blind and sighted individuals. Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:3008-3011. PMID: 29060531.
      View in: PubMed
    6. Gajawelli N, Deoni S, Dirks H, Dean D, O'Muircheartaigh J, Nelson MD, Coulon O, Lepore N. Central sulcus development in early childhood. Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:161-164. PMID: 29059835.
      View in: PubMed
    7. Lepore N, Cashin M, Bartley D, Ardelean DS. Atypical monoarthritis presentation in children with oligoarticular juvenile idiopathic arthritis: a case series. Pediatr Rheumatol Online J. 2017 Jan 13; 15(1):2. PMID: 28086918.
      View in: PubMed
    8. Yepes-Calderon F, Lao Y, Fillard P, Nelson MD, Panigrahy A, Lepore N. Tractography in the clinics: Implementing a pipeline to characterize early brain development. Neuroimage Clin. 2017; 14:629-640. PMID: 28348954.
      View in: PubMed
    9. Lao Y, Kang Y, Collignon O, Brun C, Kheibai SB, Alary F, Gee J, Nelson MD, Lepore F, Lepore N. A study of brain white matter plasticity in early blinds using tract-based spatial statistics and tract statistical analysis. Neuroreport. 2015 Dec 16; 26(18):1151-4. PMID: 26559727.
      View in: PubMed
    10. Poonai N, Li J, Langford C, Lepore N, Taddio A, Gerges S, Stitt L, Teefy J, Manji K, Castelo M, Rieder M, Qui T, Matsui D, Ali S. Intraurethral Lidocaine for Urethral Catheterization in Children: A Randomized Controlled Trial. Pediatrics. 2015 Oct; 136(4):e879-86. PMID: 26416942.
      View in: PubMed
    11. Gajawelli N, Deoni S, Dirks H, Dean D, O'Muircheartaigh J, Sawardekar S, Ezis A, Wang Y, Nelson MD, Coulon O, Lepore N. Characterization of the central sulcus in the brain in early childhood. Conf Proc IEEE Eng Med Biol Soc. 2015; 2015:149-52. PMID: 26736222.
      View in: PubMed
    12. Tsao S, Gajawelli N, Hwang DH, Kriger S, Law M, Chui H, Weiner M, Lepore N. Mapping of ApoE4 Related White Matter Damage using Diffusion MRI. Proc SPIE Int Soc Opt Eng. 2014 Apr 09; 9039:90390H. PMID: 25076830.
      View in: PubMed
    13. Tsao S, Ma SJ, Michels PA, Gajawelli N, Law M, Chui H, Lepore N. The Power of Hybrid/Fusion Imaging Metrics in Future PACS Systems: A Case Study into the White Matter Hyperintensity Prenumbra using FLAIR and Diffusion MR. Proc SPIE Int Soc Opt Eng. 2014 Apr 09; 9039:90390I. PMID: 25076831.
      View in: PubMed
    14. Tsao S, Gajawelli N, Zhou J, Shi J, Ye J, Wang Y, Lepore N. Evaluating the Predictive Power of Multivariate Tensor-based Morphometry in Alzheimers Disease Progression via Convex Fused Sparse Group Lasso. Proc SPIE Int Soc Opt Eng. 2014 Mar 21; 9034:90342L. PMID: 25076826.
      View in: PubMed
    15. Yepes-Calderon F, Velasquez A, Lepore N, Beuf O. Magnetic resonance image enhancement by reducing receptors' effective size and enabling multiple channel acquisition. Conf Proc IEEE Eng Med Biol Soc. 2014; 2014:2420-3. PMID: 25570478.
      View in: PubMed
    16. Gajawelli N, Lao Y, Apuzzo ML, Romano R, Liu C, Tsao S, Hwang D, Wilkins B, Lepore N, Law M. Neuroimaging changes in the brain in contact versus noncontact sport athletes using diffusion tensor imaging. World Neurosurg. 2013 Dec; 80(6):824-8. PMID: 24120614; PMCID: PMC3901423.
    17. Panigrahy A, Wisnowski JL, Furtado A, Lepore N, Paquette L, Bluml S. Neuroimaging biomarkers of preterm brain injury: toward developing the preterm connectome. Pediatr Radiol. 2012 Jan; 42 Suppl 1:S33-61. PMID: 22395719; PMCID: PMC4517479.
    18. Henry LC, Tremblay J, Tremblay S, Lee A, Brun C, Lepore N, Theoret H, Ellemberg D, Lassonde M. Acute and chronic changes in diffusivity measures after sports concussion. J Neurotrauma. 2011 Oct; 28(10):2049-59. PMID: 21864134.
      View in: PubMed
    19. Brun CC, Lepore N, Pennec X, Chou YY, Lee AD, de Zubicaray G, McMahon KL, Wright MJ, Gee JC, Thompson PM. A nonconservative Lagrangian framework for statistical fluid registration-SAFIRA. IEEE Trans Med Imaging. 2011 Feb; 30(2):184-202. PMID: 20813636.
      View in: PubMed
    20. Jahanshad N, Lee AD, Lepore N, Chou YY, Brun C, Barysheva M, Toga AW, McMahon KL, de Zubicaray GI, Wright MJ, Sapiro G, Lenglet C, Thompson PM. REDUCING STRUCTURAL VARIATION TO DETERMINE THE GENETICS OF WHITE MATTER INTEGRITY ACROSS HEMISPHERES - A DTI STUDY OF 100 TWINS. Proc IEEE Int Symp Biomed Imaging. 2009 Jun-Jul; 2009:819-822. PMID: 29805733.
      View in: PubMed
    21. Luders E, Toga AW, Lepore N, Gaser C. The underlying anatomical correlates of long-term meditation: larger hippocampal and frontal volumes of gray matter. Neuroimage. 2009 Apr 15; 45(3):672-8. PMID: 19280691; PMCID: PMC3184843.
    22. Lee AD, Lepore N, Lepore F, Alary F, Voss P, Chou Y, Brun C, Barysheva M, Toga AW, Thompson PM. Brain Differences Visualized in the Blind using Tensor Manifold Statistics and Diffusion Tensor Imaging. Proc Front Converg Biosci Inf Technol (2007). 2007 Oct; 2007:470-476. PMID: 29962509.
      View in: PubMed
    23. Hua X, Leow AD, Lee S, Klunder AD, Toga AW, Lepore N, Chou YY, Brun C, Chiang MC, Barysheva M, Jack CR, Bernstein MA, Britson PJ, Ward CP, Whitwell JL, Borowski B, Fleisher AS, Fox NC, Boyes RG, Barnes J, Harvey D, Kornak J, Schuff N, Boreta L, Alexander GE, Weiner MW, Thompson PM. 3D characterization of brain atrophy in Alzheimer's disease and mild cognitive impairment using tensor-based morphometry. Neuroimage. 2008 May 15; 41(1):19-34. PMID: 18378167; PMCID: PMC2556222.
    24. Lepore N, Brun CA, Chiang MC, Chou YY, Dutton RA, Hayashi KM, Lopez OL, Aizenstein HJ, Toga AW, Becker JT, Thompson PM. Multivariate statistics of the Jacobian matrices in tensor based morphometry and their application to HIV/AIDS. Med Image Comput Comput Assist Interv. 2006; 9(Pt 1):191-8. PMID: 17354890.
      View in: PubMed
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