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Stefan Bluml, PhD

Title(s)Associate Professor of Research Radiology
AddressCHL Rad 81
Off Campus
Los Angeles CA 90089
Phone+1 323 361 5730
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    Pediatric brain tumors are the second most frequent malignancy of childhood, exceeded only by leukemia and are the leading cause of death from cancer in pediatric oncology. Dr. Blüml studies the metabolism of these tumors in vivo with the goals of better initial diagnoses and characterization, to predict outcomes, and to identify early predictors of the effectiveness of therapies. Newborn brain development: After birth there are monumental developmental changes of the brain whereby helpless infants transform into children and adults capable of the complex cognitive and behavioral processes necessary to function independently in modern society. Particularly critical is early brain development the time during which multiple neurocognitive disorders emerge. At the core, the marked behavioral changes between infancy and adolescence reflect structural maturational changes (e.g., axonal outgrowth, dendritic arborization, myelination, gliogenesis, angiogenesis) and functional maturational changes (e.g., Hebbian learning processes). Dr. Blüml and his collaborators use non-invasive imaging methods to study complex metabolic processes that accompany brain maturation with the goals to establish normal biochemical maturation of the human brain as well as to better characterize abnormal development at a microscopic level.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rare Pediatric Invasive Gliofibroma Has BRAFV600E Mutation and Transiently Responds to Targeted Therapy Before Progressive Clonal Evolution. JCO Precis Oncol. 2019; 3. Kaneva K, Yeo KK, Hawes D, Ji J, Biegel JA, Nelson MD, Bluml S, Krieger MD, Erdreich-Epstein A. PMID: 31179415.
      View in: PubMed   Mentions:
    2. Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Nat Prod Rep. 2019 01 01; 36(1):248-249. McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, Crimmins MT, Csete M, Dewapriya P, Egan JM, Garson MJ, Genta-Jouve G, Gerwick WH, Gross H, Harper MK, Hermanto P, Hook JM, Hunter L, Jeannerat D, Ji NY, Johnson TA, Kingston DGI, Koshino H, Lee HW, Lewin G, Li J, Linington RG, Liu M, McPhail KL, Molinski TF, Moore BS, Nam JW, Neupane RP, Niemitz M, Nuzillard JM, Oberlies NH, Ocampos FMM, Pan G, Quinn RJ, Reddy DS, Renault JH, Rivera-Chávez J, Robien W, Saunders CM, Schmidt TJ, Seger C, Shen B, Steinbeck C, Stuppner H, Sturm S, Taglialatela-Scafati O, Tantillo DJ, Verpoorte R, Wang BG, Williams CM, Williams PG, Wist J, Yue JM, Zhang C, Xu Z, Simmler C, Lankin DC, Bisson J, Pauli GF. PMID: 30468235.
      View in: PubMed   Mentions: 1     Fields:    
    3. Association between Subcortical Morphology and Cerebral White Matter Energy Metabolism in Neonates with Congenital Heart Disease. Sci Rep. 2018 09 19; 8(1):14057. Gertsvolf N, Votava-Smith JK, Ceschin R, Del Castillo S, Lee V, Lai HA, Bluml S, Paquette L, Panigrahy A. PMID: 30232359.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Nat Prod Rep. 2019 01 01; 36(1):35-107. McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, Crimmins MT, Csete M, Dewapriya P, Egan JM, Garson MJ, Genta-Jouve G, Gerwick WH, Gross H, Harper MK, Hermanto P, Hook JM, Hunter L, Jeannerat D, Ji NY, Johnson TA, Kingston DGI, Koshino H, Lee HW, Lewin G, Li J, Linington RG, Liu M, McPhail KL, Molinski TF, Moore BS, Nam JW, Neupane RP, Niemitz M, Nuzillard JM, Oberlies NH, Ocampos FMM, Pan G, Quinn RJ, Reddy DS, Renault JH, Rivera-Chávez J, Robien W, Saunders CM, Schmidt TJ, Seger C, Shen B, Steinbeck C, Stuppner H, Sturm S, Taglialatela-Scafati O, Tantillo DJ, Verpoorte R, Wang BG, Williams CM, Williams PG, Wist J, Yue JM, Zhang C, Xu Z, Simmler C, Lankin DC, Bisson J, Pauli GF. PMID: 30003207.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    5. Noninvasive estimation of fetal lung maturity with magnetic resonance spectroscopy. Am J Obstet Gynecol. 2018 08; 219(2):209-210. Bluml S, Rajagopalan V. PMID: 29750953.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Extending PACS Functionality: Towards Facilitating the Conversion of Clinical Necessities into Research-Derived Applications. Proc SPIE Int Soc Opt Eng. 2016 Dec; 10160. Yepes-Calderon F, Wihardja F, Melamed E, Song M, Paladini G, Lepore N, Nelson M, Erberich S, Bluml S, McComb JG. PMID: 31178617.
      View in: PubMed   Mentions:
    7. Clinical Factors Associated with Cerebral Metabolism in Term Neonates with Congenital Heart Disease. J Pediatr. 2017 04; 183:67-73.e1. Harbison AL, Votava-Smith JK, Del Castillo S, Kumar SR, Lee V, Schmithorst V, Lai HA, O'Neil S, Bluml S, Paquette L, Panigrahy A. PMID: 28109537.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. The Impact of Venoarterial and Venovenous Extracorporeal Membrane Oxygenation on Cerebral Metabolism in the Newborn Brain. PLoS One. 2016; 11(12):e0168578. Reitman AJ, Chapman R, Stein JE, Paquette L, Panigrahy A, Nelson MD, Friedlich P, Wisnowski JL, Bluml S. PMID: 28033354.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Changes in Imaging and Cognition in Juvenile Rats After Whole-Brain Irradiation. Int J Radiat Oncol Biol Phys. 2016 10 01; 96(2):470-478. Brown RJ, Jun BJ, Cushman JD, Nguyen C, Beighley AH, Blanchard J, Iwamoto K, Schaue D, Harris NG, Jentsch JD, Bluml S, McBride WH. PMID: 27478168.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    10. Assessment of diffusion tensor image quality across sites and vendors using the American College of Radiology head phantom. J Appl Clin Med Phys. 2016 05 08; 17(3):442-451. Wang ZJ, Seo Y, Babcock E, Huang H, Bluml S, Wisnowski J, Holshouser B, Panigrahy A, Shaw DW, Altman N, McColl RW, Rollins NK. PMID: 27167268.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Brain temperature in neonates with hypoxic-ischemic encephalopathy during therapeutic hypothermia. J Pediatr. 2014 Dec; 165(6):1129-34. Wu TW, McLean C, Friedlich P, Wisnowski J, Grimm J, Panigrahy A, Bluml S, Seri I. PMID: 25151196.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    12. Characterization of microstructural injury: a novel approach in infant abusive head trauma-initial experience. J Neurotrauma. 2014 Oct 01; 31(19):1632-8. Imagawa KK, Hamilton A, Ceschin R, Tokar E, Pham P, Bluml S, Wisnowski J, Panigrahy A. PMID: 24831582.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Repeatability of chemical-shift-encoded water-fat MRI and diffusion-tensor imaging in lower extremity muscles in children. AJR Am J Roentgenol. 2014 Jun; 202(6):W567-73. Ponrartana S, Andrade KE, Wren TA, Ramos-Platt L, Hu HH, Bluml S, Gilsanz V. PMID: 24848851.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    14. Maintenance of whole-body therapeutic hypothermia during patient transport and magnetic resonance imaging. Pediatr Radiol. 2014 May; 44(5):613-7. Wu TW, McLean C, Friedlich P, Grimm J, Bluml S, Seri I. PMID: 24442339.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    15. Guidelines for acquiring and reporting clinical neurospectroscopy. Semin Neurol. 2012 Sep; 32(4):432-53. Lin A, Tran T, Bluml S, Merugumala S, Liao HJ, Ross BD. PMID: 23361487.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    16. Neuroimaging biomarkers of preterm brain injury: toward developing the preterm connectome. Pediatr Radiol. 2012 Jan; 42 Suppl 1:S33-61. Panigrahy A, Wisnowski JL, Furtado A, Lepore N, Paquette L, Bluml S. PMID: 22395719.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    17. Elevated citrate in pediatric astrocytomas with malignant progression. Neuro Oncol. 2011 Oct; 13(10):1107-17. Blüml S, Panigrahy A, Laskov M, Dhall G, Krieger MD, Nelson MD, Finlay JL, Gilles FH. PMID: 21771868.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    18. Bone marrow fat is inversely related to cortical bone in young and old subjects. J Clin Endocrinol Metab. 2011 Mar; 96(3):782-6. Wren TA, Chung SA, Dorey FJ, Bluml S, Adams GB, Gilsanz V. PMID: 21177790.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    19. Treatment of children with recurrent high grade gliomas with a bevacizumab containing regimen. J Neurooncol. 2011 Jul; 103(3):673-80. Parekh C, Jubran R, Erdreich-Epstein A, Panigrahy A, Bluml S, Finlay J, Dhall G. PMID: 21038110.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    20. Contralateral hemimicrencephaly in neonatal hemimegalencephaly. Pediatr Radiol. 2010 Nov; 40(11):1826-30. Shiroishi MS, Jackson HA, Nelson MD, Bluml S, Panigrahy A. PMID: 20349057.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Visualization of cerebrospinal fluid movement with spin labeling at MR imaging: preliminary results in normal and pathophysiologic conditions. Radiology. 2008 Nov; 249(2):644-52. Yamada S, Miyazaki M, Kanazawa H, Higashi M, Morohoshi Y, Bluml S, McComb JG. PMID: 18936318.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    22. Three-point technique of fat quantification of muscle tissue as a marker of disease progression in Duchenne muscular dystrophy: preliminary study. AJR Am J Roentgenol. 2008 Jan; 190(1):W8-12. Wren TA, Bluml S, Tseng-Ong L, Gilsanz V. PMID: 18094282.
      View in: PubMed   Mentions: 77     Fields:    Translation:Humans
    23. Regulation of dendritic cell differentiation and subset distribution by the zinc finger protein CTCF. Immunol Lett. 2007 Apr 15; 109(2):165-74. Koesters C, Unger B, Bilic I, Schmidt U, Bluml S, Lichtenberger B, Schreiber M, Stockl J, Ellmeier W. PMID: 17368809.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    24. Proton magnetic resonance spectroscopy of hydrocephalic infants. Pediatr Neurosurg. 2007; 43(6):461-7. McNatt SA, McComb JG, Nelson MD, Bluml S. PMID: 17992033.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    25. Differentiation of choroid plexus tumors by advanced magnetic resonance spectroscopy. Neurosurg Focus. 2005 Jun 15; 18(6A):E4. Krieger MD, Panigrahy A, McComb JG, Nelson MD, Liu X, Gonzalez-Gomez I, Gilles F, Bluml S. PMID: 16048290.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    26. MRI tracer study of the cerebrospinal fluid drainage pathway in normal and hydrocephalic guinea pig brain. Tokai J Exp Clin Med. 2005 Apr; 30(1):21-9. Yamada S, Shibata M, Scadeng M, Bluml S, Nguy C, Ross B, McComb JG. PMID: 15952295.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    27. MR imaging of newborns by using an MR-compatible incubator with integrated radiofrequency coils: initial experience. Radiology. 2004 May; 231(2):594-601. Blüml S, Friedlich P, Erberich S, Wood JC, Seri I, Nelson MD. PMID: 15128999.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    28. In vivo characterization of fatty acids in human adipose tissue using natural abundance 1H decoupled 13C MRS at 1.5 T: clinical applications to dietary therapy. NMR Biomed. 2003 May; 16(3):160-7. Hwang JH, Bluml S, Leaf A, Ross BD. PMID: 12884360.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    29. Evolving techniques for the investigation of muscle bioenergetics and oxygenation. Biochem Soc Trans. 2002 Apr; 30(2):232-7. Richardson RS, Noyszewski EA, Haseler LJ, Bluml S, Frank LR. PMID: 12023857.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    30. Local perfusion and metabolic demand during exercise: a noninvasive MRI method of assessment. J Appl Physiol (1985). 2001 Oct; 91(4):1845-53. Richardson RS, Haseler LJ, Nygren AT, Bluml S, Frank LR. PMID: 11568171.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCTClinical Trials
    31. Magnetic resonance spectroscopy of the human brain. Anat Rec. 2001 04; 265(2):54-84. Ross B, Bluml S. PMID: 11323770.
      View in: PubMed   Mentions: 105     Fields:    Translation:Humans
    32. Identification of cerebral acetone by 1H-MRS in patients with epilepsy controlled by ketogenic diet. MAGMA. 1999 Mar; 8(1):33-42. Seymour KJ, Bluml S, Sutherling J, Sutherling W, Ross BD. PMID: 10383091.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    33. Efficacy of proton magnetic resonance spectroscopy in clinical decision making for patients with suspected malignant brain tumors. J Neurooncol. 1999; 45(1):69-81. Lin A, Bluml S, Mamelak AN. PMID: 10728912.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansPHPublic Health
    34. In vivo MR spectroscopy of human dementia. Neuroimaging Clin N Am. 1998 Nov; 8(4):809-22. Ross BD, Bluml S, Cowan R, Danielsen E, Farrow N, Tan J. PMID: 9769343.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    35. MR of hypoxic encephalopathy in children after near drowning: correlation with quantitative proton MR spectroscopy and clinical outcome. AJNR Am J Neuroradiol. 1998 Oct; 19(9):1617-27. Dubowitz DJ, Bluml S, Arcinue E, Dietrich RB. PMID: 9802481.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    36. Proton-decoupled 31P magnetic resonance spectroscopy reveals osmotic and metabolic disturbances in human hepatic encephalopathy. J Neurochem. 1998 Oct; 71(4):1564-76. Bluml S, Zuckerman E, Tan J, Ross BD. PMID: 9751190.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    37. Lack of effect of oral choline supplement on the concentrations of choline metabolites in human brain. Magn Reson Med. 1998 Jun; 39(6):1005-10. Tan J, Bluml S, Hoang T, Dubowitz D, Mevenkamp G, Ross B. PMID: 9621925.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    38. Quantitative proton-decoupled 31P MRS and 1H MRS in the evaluation of Huntington's and Parkinson's diseases. Neurology. 1998 Apr; 50(4):1033-40. Hoang TQ, Bluml S, Dubowitz DJ, Moats R, Kopyov O, Jacques D, Ross BD. PMID: 9566391.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    39. In vivo magnetic resonance spectroscopy of human brain: the biophysical basis of dementia. Biophys Chem. 1997 Oct; 68(1-3):161-72. Ross BD, Bluml S, Cowan R, Danielsen E, Farrow N, Gruetter R. PMID: 9468618.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    40. Differentiation between cortical atrophy and hydrocephalus using 1H MRS. Magn Reson Med. 1997 Mar; 37(3):395-403. Bluml S, McComb JG, Ross BD. PMID: 9055230.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    41. Magnetic resonance spectroscopy in the study of hyperammonemia and hepatic encephalopathy. Adv Exp Med Biol. 1997; 420:185-94. Kanamori K, Bluml S, Ross B. PMID: 9286434.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    42. Evidence from proton magnetic resonance spectroscopy for a metabolic cascade of neuronal damage in shaken baby syndrome. Pediatrics. 1997 Jan; 99(1):4-14. Haseler LJ, Arcinue E, Danielsen ER, Bluml S, Ross BD. PMID: 8989330.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
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