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    Brent J. Liu, PhD

    TitleAssociate Professor of Engineering Practice
    SchoolViterbi School of Engineering, BME
    DepartmentImaging Training Program
    Address1042 Downey Way
    University Park Campus
    Los Angeles California 90089-1111
    Phone+1 213 821 1912
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      Dr. Brent Liu earned a Ph.D. degree from the UCLA Biomedical Physics Graduate Program and performed research as a Post Doctorate. During his graduate student research at UCLA from 1991 to 1996, Dr. Brent Liu had been involved in various medical image processing and informatics research projects. These include the analyses, design, implementation, and evaluation of an automatic image segmentation system based on object-oriented, knowledge base, and database-engineering principles applied to the image segmentation of bones in pediatric hand radiographs. Dr. Liu also researched and developed several image-processing applications such as image noise smoothing based on merging cluster of pixels with the aid of statistical information, removal of grid line artifacts in digitized X-ray images using Fourier Analysis filtering.

      Upon graduation, Dr. Liu continued his post-doctorate research at UCLA from 1996 to 1999. During this time, Dr. Liu researched and designed a software module to capture Medical Imaging and Information data for the purposes of teaching, reviewing, and conferencing on a PACS workstation. Along with this software module, Dr. Liu contributed to the development of a suite of object-oriented class libraries to support methodological development of diagnostic PACS workstation functions and applications. These included the development of a software toolkit to convert current UCLA-proprietary PACS data into DICOM-compliant data files and the research of the use of adaptive and intelligent user interfaces and reading protocols in diagnostic PACS workstations.

      From 1999 to 2002, he lead the implementation of a fully filmless PACS in a clinical setting within the Imaging Department of a high-profile community hospital (Saint John's Health Care, Santa Monica, CA). This included not only LAN PACS within the hospital but also WAN PACS to the physician's desktops. He was also involved with the planning and integration of other new information and imaging systems related to PACS, which include Nuclear Medicine and Radiation Oncology along with Radiology. He has served as a PACS consultant for another hospital to assist them in their integration of a fully filmless PACS. In 2002 to 2003, he also managed the implementation of a fully filmless PACS within a high-profile academic hospital (University of California Los Angeles Healthcare, Westwood, CA) that has multiple campus sites. His experience in PACS implementation is unique since he has had multiple contacts and interactions with various healthcare centers as well as the imaging industry. In addition, he brings hands-on practical knowledge of implementing different vendor PACS in both a high-profile community hospital and a large-scale academic hospital and the different experiences associated with both.

      In 2003 he held an Honorary Lectureship at the Hong Kong Polytechnic University where he taught workshop courses in PACS Implementation, and Acceptance Testing Design/Development.

      For the past five years, he has been actively administering and training within the Biomedical Imaging Informatics Training Program guiding trainees into different avenues of medical imaging informatics research. This current proposal is a competitive renewal application for the continuation of this training program. He has been strategic in bridging the gap between the two schools of engineering and medicine, as well as the different disciplines of learning, to help guide undergraduate, graduate, and post-graduate students and trainees to perform clinically translational and collaborative research within Medical Imaging Informatics. He teaches two required Graduate level courses at the Biomedical Engineering Department in Medical Imaging Informatics (BME527: Integration of Medical Imaging Systems & BME528: Medical Imaging Informatics).


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Edwardson MA, Wang X, Liu B, Ding L, Lane CJ, Park C, Nelsen MA, Jones TA, Wolf SL, Winstein CJ, Dromerick AW. Stroke Lesions in a Large Upper Limb Rehabilitation Trial Cohort Rarely Match Lesions in Common Preclinical Models. Neurorehabil Neural Repair. 2017 Jan 01; 1545968316688799. PMID: 28337932.
        View in: PubMed
      2. Deshpande RR, DeMarco J, Sayre JW, Liu B. Knowledge-driven decision support for assessing dose distributions in radiation therapy of head and neck cancer. Int J Comput Assist Radiol Surg. 2016 Nov; 11(11):2071-2083. PMID: 27072838.
        View in: PubMed
      3. Ma KC, Fernandez JR, Amezcua L, Lerner A, Shiroishi MS, Liu B. Design and development of an ethnically-diverse imaging informatics-based eFolder system for multiple sclerosis patients. Comput Med Imaging Graph. 2015 Dec; 46 Pt 2:257-68. PMID: 26564667.
        View in: PubMed
      4. Garrison KA, Rogalsky C, Sheng T, Liu B, Damasio H, Winstein CJ, Aziz-Zadeh LS. Functional MRI Preprocessing in Lesioned Brains: Manual Versus Automated Region of Interest Analysis. Front Neurol. 2015; 6:196. PMID: 26441816.
        View in: PubMed
      5. Zhang X, Gao X, Liu B, Ma K, Yan W, Liling L, Yuhong H, Fujita H. Effective staging of fibrosis by the selected texture features of liver: Which one is better, CT or MR imaging? Comput Med Imaging Graph. 2015 Dec; 46 Pt 2:227-36. PMID: 26455963.
        View in: PubMed
      6. Wang X, Liu B, Martinez C, Zhang X, Winstein CJ. Development of a novel imaging informatics-based system with an intelligent workflow engine (IWEIS) to support imaging-based clinical trials. Comput Biol Med. 2016 Feb 1; 69:261-9. PMID: 25870169.
        View in: PubMed
      7. Huang HK, Deshpande R, Documet J, Le AH, Lee J, Ma K, Liu B. Medical imaging informatics simulators: a tutorial. Int J Comput Assist Radiol Surg. 2014 May; 9(3):433-47. PMID: 24037463.
        View in: PubMed
      8. Moin P, Deshpande R, Sayre J, Messer E, Gupte S, Romsdahl H, Hasegawa A, Liu B. An observer study for a computer-aided reading protocol (CARP) in the screening environment for digital mammography. Acad Radiol. 2011 Nov; 18(11):1420-9. PMID: 21971259.
        View in: PubMed
      9. Lee J, Zhang J, Park R, Dagliyan G, Liu B, Huang HK. A DICOM-based 2nd generation Molecular Imaging Data Grid implementing the IHE XDS-i integration profile. Int J Comput Assist Radiol Surg. 2012 Jul; 7(4):533-45. PMID: 21877136.
        View in: PubMed
      10. Le AH, Liu B, Schulte R, Huang HK. Intelligent ePR system for evidence-based research in radiotherapy: proton therapy for prostate cancer. Int J Comput Assist Radiol Surg. 2011 Nov; 6(6):769-84. PMID: 21409498.
        View in: PubMed
      11. Lee J, Documet J, Liu B, Park R, Tank A, Huang HK. MIDG-Emerging grid technologies for multi-site preclinical molecular imaging research communities. Int J Comput Assist Radiol Surg. 2011 Mar; 6(2):285-96. PMID: 20690000.
        View in: PubMed
      12. Chiu JC, Maziad AM, Rappard G, Thacker JT, Liu B, Documet J. Evolving minimally invasive spine surgery: a surgeon's perspective on technological convergence and digital or control system. Surg Technol Int. 2010 Apr; 19:211-22. PMID: 20437367.
        View in: PubMed
      13. Documet J, Le A, Liu B, Chiu J, Huang HK. A multimedia electronic patient record (ePR) system for image-assisted minimally invasive spinal surgery. Int J Comput Assist Radiol Surg. 2010 May; 5(3):195-209. PMID: 20033507.
        View in: PubMed
      14. Law MY, Liu B, Chan LW. Informatics in radiology: DICOM-RT-based electronic patient record information system for radiation therapy. Radiographics. 2009 Jul-Aug; 29(4):961-72. PMID: 19448106.
        View in: PubMed
      15. Le AH, Liu B, Huang HK. Integration of computer-aided diagnosis/detection (CAD) results in a PACS environment using CAD-PACS toolkit and DICOM SR. Int J Comput Assist Radiol Surg. 2009 Jun; 4(4):317-29. PMID: 20033579.
        View in: PubMed
      16. Law MY, Liu B. Informatics in radiology: DICOM-RT and its utilization in radiation therapy. Radiographics. 2009 May-Jun; 29(3):655-67. PMID: 19270073.
        View in: PubMed
      17. Lieberman R, Kwong H, Liu B, Huang H. Computer-assisted detection (CAD) methodology for early detection of response to pharmaceutical therapy in tuberculosis patients. Proc SPIE Int Soc Opt Eng. 2009; 7260:726030. PMID: 19953192.
        View in: PubMed
      18. Mung J, Han S, Fullerton D, Bond A, Liu B, Weaver F, Yen J. An ultrasonic navigation system for endovascular aortic repair. Stud Health Technol Inform. 2009; 142:218-20. PMID: 19377153.
        View in: PubMed
      19. Zhang A, Sayre JW, Vachon L, Liu B, Huang HK. Racial differences in growth patterns of children assessed on the basis of bone age. Radiology. 2009 Jan; 250(1):228-35. PMID: 18955510.
        View in: PubMed
      20. Liu B. A knowledge-based imaging informatics approach for managing proton beam therapy of cancer patients. Technol Cancer Res Treat. 2007 Aug; 6(4 Suppl):77-84. PMID: 17668957.
        View in: PubMed
      21. Liu B, Law MY, Documet J, Gertych A. Image-assisted knowledge discovery and decision support in radiation therapy planning. Comput Med Imaging Graph. 2007 Jun-Jul; 31(4-5):311-21. PMID: 17367994.
        View in: PubMed
      22. Zhou Z, Liu B, Le AH. CAD-PACS integration tool kit based on DICOM secondary capture, structured report and IHE workflow profiles. Comput Med Imaging Graph. 2007 Jun-Jul; 31(4-5):346-52. PMID: 17386997.
        View in: PubMed
      23. Zhang A, Gertych A, Liu B. Automatic bone age assessment for young children from newborn to 7-year-old using carpal bones. Comput Med Imaging Graph. 2007 Jun-Jul; 31(4-5):299-310. PMID: 17369018.
        View in: PubMed
      24. Guo B, Documet J, Lee J, Liu B, King N, Shrestha R, Wang K, Huang HK, Grant EG. Experiences with a prototype tracking and verification system implemented within an imaging center. Acad Radiol. 2007 Mar; 14(3):270-8. PMID: 17307659.
        View in: PubMed
      25. Documet J, Liu B, Documet L, Huang HK. Wireless remote control of clinical image workflow: using a PDA for off-site distribution and disaster recovery. J Am Coll Radiol. 2006 Jul; 3(7):520-7. PMID: 17412116.
        View in: PubMed
      26. Liu B, Zhou Z, Huang HK. A HIPAA-compliant architecture for securing clinical images. J Digit Imaging. 2006 Jun; 19(2):172-80. PMID: 16341963.
        View in: PubMed
      27. King NE, Documet J, Liu B. Predicting clinical image delivery time by monitoring PACS queue behavior. J Digit Imaging. 2006; 19 Suppl 1:35-43. PMID: 16598644.
        View in: PubMed
      28. Zhou Z, Liu B. HIPAA compliant auditing system for medical images. Comput Med Imaging Graph. 2005 Mar-Apr; 29(2-3):235-41. PMID: 15755540.
        View in: PubMed
      29. Liu B, Zhou MZ, Documet J. Utilizing data grid architecture for the backup and recovery of clinical image data. Comput Med Imaging Graph. 2005 Mar-Apr; 29(2-3):95-102. PMID: 15755529.
        View in: PubMed
      30. Huang HK, Liu B, Zhou Z. A continuous available (CA) server for medical imaging applications. Acad Radiol. 2004 Jul; 11(7):767-78. PMID: 15217594.
        View in: PubMed
      31. Liu B, Huang HK, Cao F, Zhou MZ, Zhang J, Mogel G. Informatics in radiology (infoRAD): A complete continuous-availability PACS archive server. Radiographics. 2004 Jul-Aug; 24(4):1203-9. PMID: 15256640.
        View in: PubMed