Brent J. Liu, PhD

Title(s)Associate Professor of Engineering Practice
SchoolViterbi School of Engineering, Bme
Address1042 Downey Way
University Park Campus
Los Angeles CA 90089-1111
Phone+1 213 821 1912
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    Dr. Brent Liu earned a Ph.D. degree from the UCLA Biomedical Physics Graduate Program and performed research as a Post Doctorate. During his graduate student research at UCLA from 1991 to 1996, Dr. Brent Liu had been involved in various medical image processing and informatics research projects. These include the analyses, design, implementation, and evaluation of an automatic image segmentation system based on object-oriented, knowledge base, and database-engineering principles applied to the image segmentation of bones in pediatric hand radiographs. Dr. Liu also researched and developed several image-processing applications such as image noise smoothing based on merging cluster of pixels with the aid of statistical information, removal of grid line artifacts in digitized X-ray images using Fourier Analysis filtering.

    Upon graduation, Dr. Liu continued his post-doctorate research at UCLA from 1996 to 1999. During this time, Dr. Liu researched and designed a software module to capture Medical Imaging and Information data for the purposes of teaching, reviewing, and conferencing on a PACS workstation. Along with this software module, Dr. Liu contributed to the development of a suite of object-oriented class libraries to support methodological development of diagnostic PACS workstation functions and applications. These included the development of a software toolkit to convert current UCLA-proprietary PACS data into DICOM-compliant data files and the research of the use of adaptive and intelligent user interfaces and reading protocols in diagnostic PACS workstations.

    From 1999 to 2002, he lead the implementation of a fully filmless PACS in a clinical setting within the Imaging Department of a high-profile community hospital (Saint John's Health Care, Santa Monica, CA). This included not only LAN PACS within the hospital but also WAN PACS to the physician's desktops. He was also involved with the planning and integration of other new information and imaging systems related to PACS, which include Nuclear Medicine and Radiation Oncology along with Radiology. He has served as a PACS consultant for another hospital to assist them in their integration of a fully filmless PACS. In 2002 to 2003, he also managed the implementation of a fully filmless PACS within a high-profile academic hospital (University of California Los Angeles Healthcare, Westwood, CA) that has multiple campus sites. His experience in PACS implementation is unique since he has had multiple contacts and interactions with various healthcare centers as well as the imaging industry. In addition, he brings hands-on practical knowledge of implementing different vendor PACS in both a high-profile community hospital and a large-scale academic hospital and the different experiences associated with both.

    In 2003 he held an Honorary Lectureship at the Hong Kong Polytechnic University where he taught workshop courses in PACS Implementation, and Acceptance Testing Design/Development.

    For the past five years, he has been actively administering and training within the Biomedical Imaging Informatics Training Program guiding trainees into different avenues of medical imaging informatics research. This current proposal is a competitive renewal application for the continuation of this training program. He has been strategic in bridging the gap between the two schools of engineering and medicine, as well as the different disciplines of learning, to help guide undergraduate, graduate, and post-graduate students and trainees to perform clinically translational and collaborative research within Medical Imaging Informatics. He teaches two required Graduate level courses at the Biomedical Engineering Department in Medical Imaging Informatics (BME527: Integration of Medical Imaging Systems & BME528: Medical Imaging Informatics).

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Genetic Factors, Brain Atrophy, and Response to Rehabilitation Therapy After Stroke. Neurorehabil Neural Repair. 2022 02; 36(2):131-139. Cramer SC, See J, Liu B, Edwardson M, Wang X, Radom-Aizik S, Haddad F, Shahbaba B, Wolf SL, Dromerick AW, Winstein CJ. PMID: 34933635; PMCID: PMC8792305.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    2. Development of an integrated biomechanics informatics system with knowledge discovery and decision support tools for research of injury prevention and performance enhancement. Comput Biol Med. 2022 02; 141:105062. Liu J, Stewart H, Wiens C, Mcnitt-Gray J, Liu B. PMID: 34836623.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Optic Disc and Cup Image Segmentation Utilizing Contour-Based Transformation and Sequence Labeling Networks. J Med Syst. 2020 Mar 20; 44(5):96. Xie Z, Ling T, Yang Y, Shu R, Liu BJ. PMID: 32193703.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    4. Stroke Lesions in a Large Upper Limb Rehabilitation Trial Cohort Rarely Match Lesions in Common Preclinical Models. Neurorehabil Neural Repair. 2017 Jun; 31(6):509-520. Edwardson MA, Wang X, Liu B, Ding L, Lane CJ, Park C, Nelsen MA, Jones TA, Wolf SL, Winstein CJ, Dromerick AW. PMID: 28337932; PMCID: PMC5433918.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    5. Knowledge-driven decision support for assessing dose distributions in radiation therapy of head and neck cancer. Int J Comput Assist Radiol Surg. 2016 Nov; 11(11):2071-2083. Deshpande RR, DeMarco J, Sayre JW, Liu BJ. PMID: 27072838.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    6. Multidimensional Interactive Radiology Report and Analysis: Standardization of workflow and reporting for renal mass tracking and quantification. Proc SPIE Int Soc Opt Eng. 2015 Nov; 9681. Hwang DH, Ma K, Yepes F, Nadamuni M, Nayyar M, Liu B, Duddalwar V, Lepore N. PMID: 31178621; PMCID: PMC6554203.
      View in: PubMed   Mentions: 1  
    7. Design and development of an ethnically-diverse imaging informatics-based eFolder system for multiple sclerosis patients. Comput Med Imaging Graph. 2015 Dec; 46 Pt 2:257-68. Ma KC, Fernandez JR, Amezcua L, Lerner A, Shiroishi MS, Liu BJ. PMID: 26564667; PMCID: PMC4936902.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Functional MRI Preprocessing in Lesioned Brains: Manual Versus Automated Region of Interest Analysis. Front Neurol. 2015; 6:196. Garrison KA, Rogalsky C, Sheng T, Liu B, Damasio H, Winstein CJ, Aziz-Zadeh LS. PMID: 26441816; PMCID: PMC4585177.
      View in: PubMed   Mentions: 4  
    9. Effective staging of fibrosis by the selected texture features of liver: Which one is better, CT or MR imaging? Comput Med Imaging Graph. 2015 Dec; 46 Pt 2:227-36. Zhang X, Gao X, Liu BJ, Ma K, Yan W, Liling L, Yuhong H, Fujita H. PMID: 26455963.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    10. Development of a novel imaging informatics-based system with an intelligent workflow engine (IWEIS) to support imaging-based clinical trials. Comput Biol Med. 2016 Feb 01; 69:261-9. Wang X, Liu BJ, Martinez C, Zhang X, Winstein CJ. PMID: 25870169; PMCID: PMC4586295.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    11. Medical imaging informatics simulators: a tutorial. Int J Comput Assist Radiol Surg. 2014 May; 9(3):433-47. Huang HK, Deshpande R, Documet J, Le AH, Lee J, Ma K, Liu BJ. PMID: 24037463.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. An observer study for a computer-aided reading protocol (CARP) in the screening environment for digital mammography. Acad Radiol. 2011 Nov; 18(11):1420-9. Moin P, Deshpande R, Sayre J, Messer E, Gupte S, Romsdahl H, Hasegawa A, Liu BJ. PMID: 21971259.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    13. A DICOM-based 2nd generation Molecular Imaging Data Grid implementing the IHE XDS-i integration profile. Int J Comput Assist Radiol Surg. 2012 Jul; 7(4):533-45. Lee J, Zhang J, Park R, Dagliyan G, Liu B, Huang HK. PMID: 21877136.
      View in: PubMed   Mentions: 3     Fields:    
    14. Intelligent ePR system for evidence-based research in radiotherapy: proton therapy for prostate cancer. Int J Comput Assist Radiol Surg. 2011 Nov; 6(6):769-84. Le AH, Liu B, Schulte R, Huang HK. PMID: 21409498.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    15. MIDG-Emerging grid technologies for multi-site preclinical molecular imaging research communities. Int J Comput Assist Radiol Surg. 2011 Mar; 6(2):285-96. Lee J, Documet J, Liu B, Park R, Tank A, Huang HK. PMID: 20690000.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    16. Evolving minimally invasive spine surgery: a surgeon's perspective on technological convergence and digital or control system. Surg Technol Int. 2010 Apr; 19:211-22. Chiu JC, Maziad AM, Rappard G, Thacker JT, Liu B, Documet J. PMID: 20437367.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. A multimedia electronic patient record (ePR) system for image-assisted minimally invasive spinal surgery. Int J Comput Assist Radiol Surg. 2010 May; 5(3):195-209. Documet J, Le A, Liu B, Chiu J, Huang HK. PMID: 20033507; PMCID: PMC2845741.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    18. Informatics in radiology: DICOM-RT-based electronic patient record information system for radiation therapy. Radiographics. 2009 Jul-Aug; 29(4):961-72. Law MY, Liu B, Chan LW. PMID: 19448106.
      View in: PubMed   Mentions: 14     Fields:    
    19. Integration of computer-aided diagnosis/detection (CAD) results in a PACS environment using CAD-PACS toolkit and DICOM SR. Int J Comput Assist Radiol Surg. 2009 Jun; 4(4):317-29. Le AH, Liu B, Huang HK. PMID: 20033579.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    20. Informatics in radiology: DICOM-RT and its utilization in radiation therapy. Radiographics. 2009 May-Jun; 29(3):655-67. Law MY, Liu B. PMID: 19270073.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    21. Computer-assisted detection (CAD) methodology for early detection of response to pharmaceutical therapy in tuberculosis patients. Proc SPIE Int Soc Opt Eng. 2009; 7260:726030. Lieberman R, Kwong H, Liu B, Huang H. PMID: 19953192; PMCID: PMC2785044.
      View in: PubMed   Mentions: 4  
    22. An ultrasonic navigation system for endovascular aortic repair. Stud Health Technol Inform. 2009; 142:218-20. Mung J, Han S, Fullerton D, Bond A, Liu B, Weaver F, Yen J. PMID: 19377153.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Racial differences in growth patterns of children assessed on the basis of bone age. Radiology. 2009 Jan; 250(1):228-35. Zhang A, Sayre JW, Vachon L, Liu BJ, Huang HK. PMID: 18955510; PMCID: PMC2817832.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    24. Automated Bone Age Assessment of Older Children using the Radius. Proc SPIE Int Soc Opt Eng. 2008 Mar; 6919. Tsao S, Gertych A, Zhang A, Liu BJ, Huang HK. PMID: 29710876; PMCID: PMC5921921.
      View in: PubMed   Mentions: 1  
    25. A knowledge-based imaging informatics approach for managing proton beam therapy of cancer patients. Technol Cancer Res Treat. 2007 Aug; 6(4 Suppl):77-84. Liu BJ. PMID: 17668957.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    26. Image-assisted knowledge discovery and decision support in radiation therapy planning. Comput Med Imaging Graph. 2007 Jun-Jul; 31(4-5):311-21. Liu BJ, Law MY, Documet J, Gertych A. PMID: 17367994.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    27. CAD-PACS integration tool kit based on DICOM secondary capture, structured report and IHE workflow profiles. Comput Med Imaging Graph. 2007 Jun-Jul; 31(4-5):346-52. Zhou Z, Liu BJ, Le AH. PMID: 17386997.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    28. Automatic bone age assessment for young children from newborn to 7-year-old using carpal bones. Comput Med Imaging Graph. 2007 Jun-Jul; 31(4-5):299-310. Zhang A, Gertych A, Liu BJ. PMID: 17369018; PMCID: PMC2041862.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    29. Experiences with a prototype tracking and verification system implemented within an imaging center. Acad Radiol. 2007 Mar; 14(3):270-8. Guo B, Documet J, Lee J, Liu B, King N, Shrestha R, Wang K, Huang HK, Grant EG. PMID: 17307659.
      View in: PubMed   Mentions: 1     Fields:    
    30. Wireless remote control of clinical image workflow: using a PDA for off-site distribution and disaster recovery. J Am Coll Radiol. 2006 Jul; 3(7):520-7. Documet J, Liu BJ, Documet L, Huang HK. PMID: 17412116.
      View in: PubMed   Mentions:    Fields:    
    31. A HIPAA-compliant architecture for securing clinical images. J Digit Imaging. 2006 Jun; 19(2):172-80. Liu BJ, Zhou Z, Huang HK. PMID: 16341963; PMCID: PMC3045193.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    32. Predicting clinical image delivery time by monitoring PACS queue behavior. J Digit Imaging. 2006; 19 Suppl 1:35-43. King NE, Documet J, Liu B. PMID: 16598644; PMCID: PMC3045171.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    33. HIPAA compliant auditing system for medical images. Comput Med Imaging Graph. 2005 Mar-Apr; 29(2-3):235-41. Zhou Z, Liu BJ. PMID: 15755540.
      View in: PubMed   Mentions: 5     Fields:    
    34. Utilizing data grid architecture for the backup and recovery of clinical image data. Comput Med Imaging Graph. 2005 Mar-Apr; 29(2-3):95-102. Liu BJ, Zhou MZ, Documet J. PMID: 15755529.
      View in: PubMed   Mentions: 9     Fields:    
    35. A continuous available (CA) server for medical imaging applications. Acad Radiol. 2004 Jul; 11(7):767-78. Huang HK, Liu BJ, Zhou Z. PMID: 15217594.
      View in: PubMed   Mentions:    Fields:    
    36. Informatics in radiology (infoRAD): A complete continuous-availability PACS archive server. Radiographics. 2004 Jul-Aug; 24(4):1203-9. Liu BJ, Huang HK, Cao F, Zhou MZ, Zhang J, Mogel G. PMID: 15256640.
      View in: PubMed   Mentions: 6     Fields: