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Vassilios Papadopoulos

TitleDean
InstitutionUniversity of Southern California
DepartmentAdministration
Address1985 Zonal Avenue
Health Sciences Campus
Los Angeles CA 90033
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Fan J, Zirkin B, Papadopoulos V. Response to Letter to the Editor: "Dubious conclusions on TSPO function". Endocrinology. 2018 May 10. PMID: 29757373.
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    2. Fan J, Wang K, Zirkin B, Papadopoulos V. CRISPR/Cas9?Mediated Tspo Gene Mutations Lead to Reduced Mitochondrial Membrane Potential and Steroid Formation in MA-10 Mouse Tumor Leydig Cells. Endocrinology. 2018 02 01; 159(2):1130-1146. PMID: 29300865.
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    3. Prossin AR, Chandler M, Ryan KA, Saunders EF, Kamali M, Papadopoulos V, Zöllner S, Dantzer R, McInnis MG. Functional TSPO polymorphism predicts variance in the diurnal cortisol rhythm in bipolar disorder. Psychoneuroendocrinology. 2018 Mar; 89:194-202. PMID: 29414032.
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    4. Owen DR, Fan J, Campioli E, Venugopal S, Midzak A, Daly E, Harlay A, Issop L, Libri V, Kalogiannopoulou D, Oliver E, Gallego-Colon E, Colasanti A, Huson L, Rabiner EA, Suppiah P, Essagian C, Matthews PM, Papadopoulos V. TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis. Biochem J. 2017 11 21; 474(23):3985-3999. PMID: 29074640.
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    5. Campioli E, Lee S, Lau M, Marques L, Papadopoulos V. Effect of prenatal DINCH plasticizer exposure on rat offspring testicular function and metabolism. Sci Rep. 2017 Sep 11; 7(1):11072. PMID: 28894178.
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    6. Lee S, Martinez-Arguelles DB, Campioli E, Papadopoulos V. Fetal Exposure to Low Levels of the Plasticizer DEHP Predisposes the Adult Male Adrenal Gland to Endocrine Disruption. Endocrinology. 2017 02 01; 158(2):304-318. PMID: 27849367.
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    7. Venugopal S, Martinez-Arguelles DB, Chebbi S, Hullin-Matsuda F, Kobayashi T, Papadopoulos V. Plasma Membrane Origin of the Steroidogenic Pool of Cholesterol Used in Hormone-induced Acute Steroid Formation in Leydig Cells. J Biol Chem. 2016 Dec 09; 291(50):26109-26125. PMID: 27815506.
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    8. Midzak A, Papadopoulos V. Adrenal Mitochondria and Steroidogenesis: From Individual Proteins to Functional Protein Assemblies. Front Endocrinol (Lausanne). 2016; 7:106. PMID: 27524977; PMCID: PMC4965458.
    9. Boisvert A, Jones S, Issop L, Erythropel HC, Papadopoulos V, Culty M. In vitro functional screening as a means to identify new plasticizers devoid of reproductive toxicity. Environ Res. 2016 10; 150:496-512. PMID: 27423704.
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    10. Fan J, Li X, Issop L, Culty M, Papadopoulos V. ACBD2/ECI2-Mediated Peroxisome-Mitochondria Interactions in Leydig Cell Steroid Biosynthesis. Mol Endocrinol. 2016 Jul; 30(7):763-82. PMID: 27167610.
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    11. Issop L, Ostuni MA, Lee S, Laforge M, Péranzi G, Rustin P, Benoist JF, Estaquier J, Papadopoulos V, Lacapère JJ. Translocator Protein-Mediated Stabilization of Mitochondrial Architecture during Inflammation Stress in Colonic Cells. PLoS One. 2016; 11(4):e0152919. PMID: 27054921; PMCID: PMC4824355.
    12. Li NC, Fan J, Papadopoulos V. Sterol Carrier Protein-2, a Nonspecific Lipid-Transfer Protein, in Intracellular Cholesterol Trafficking in Testicular Leydig Cells. PLoS One. 2016; 11(2):e0149728. PMID: 26901662; PMCID: PMC4762939.
    13. Campioli E, Papadopoulos V. Cyclohexane-1,2-dicarboxylic acid diisononyl ester and metabolite effects on rat epididymal stromal vascular fraction differentiation of adipose tissue (2015) Environmental Research 140: 145-156 Reply to the letter by Otter R. Environ Res. 2016 Jan; 144(Pt A):167-169. PMID: 26597640.
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    14. Midzak A, Papadopoulos V. Steroidogenesis: The Classics and Beyond. Steroids. 2015 Nov; 103:1-2. PMID: 26526569.
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    15. Midzak A, Zirkin B, Papadopoulos V. Translocator protein: pharmacology and steroidogenesis. Biochem Soc Trans. 2015 Aug; 43(4):572-8. PMID: 26551695.
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    16. Fan J, Campioli E, Midzak A, Culty M, Papadopoulos V. Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation. Proc Natl Acad Sci U S A. 2015 Jun 09; 112(23):7261-6. PMID: 26039990; PMCID: PMC4466704.
    17. Midzak A, Denora N, Laquintana V, Cutrignelli A, Lopedota A, Franco M, Altomare CD, Papadopoulos V. 2-Phenylimidazo[1,2-a]pyridine-containing ligands of the 18-kDa translocator protein (TSPO) behave as agonists and antagonists of steroidogenesis in a mouse leydig tumor cell line. Eur J Pharm Sci. 2015 Aug 30; 76:231-7. PMID: 26002041.
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    18. Midzak AS, Akula N, Rone MB, Papadopoulos V. Computational modeling and biological validation of novel non-steroidal ligands for the cholesterol recognition/interaction amino acid consensus (CRAC) motif of the mitochondrial translocator protein (TSPO). Pharmacol Res. 2015 Sep; 99:393-403. PMID: 25936508.
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    19. Campioli E, Duong TB, Deschamps F, Papadopoulos V. Cyclohexane-1,2-dicarboxylic acid diisononyl ester and metabolite effects on rat epididymal stromal vascular fraction differentiation of adipose tissue. Environ Res. 2015 Jul; 140:145-56. PMID: 25863588.
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    20. Papadopoulos V, Aghazadeh Y, Fan J, Campioli E, Zirkin B, Midzak A. Translocator protein-mediated pharmacology of cholesterol transport and steroidogenesis. Mol Cell Endocrinol. 2015 Jun 15; 408:90-8. PMID: 25818881; PMCID: PMC4417383.
    21. Issop L, Fan J, Lee S, Rone MB, Basu K, Mui J, Papadopoulos V. Mitochondria-associated membrane formation in hormone-stimulated Leydig cell steroidogenesis: role of ATAD3. Endocrinology. 2015 Jan; 156(1):334-45. PMID: 25375035.
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    22. Meltzer D, Martinez-Arguelles DB, Campioli E, Lee S, Papadopoulos V. In utero exposure to the endocrine disruptor di(2-ethylhexyl) phthalate targets ovarian theca cells and steroidogenesis in the adult female rat. Reprod Toxicol. 2015 Jan; 51:47-56. PMID: 25530038.
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    23. Rone MB, Midzak AS, Martinez-Arguelles DB, Fan J, Ye X, Blonder J, Papadopoulos V. Steroidogenesis in MA-10 mouse Leydig cells is altered via fatty acid import into the mitochondria. Biol Reprod. 2014 Oct; 91(4):96. PMID: 25210128; PMCID: PMC4435033.
    24. Midzak A, Papadopoulos V. Binding domain-driven intracellular trafficking of sterols for synthesis of steroid hormones, bile acids and oxysterols. Traffic. 2014 Sep; 15(9):895-914. PMID: 24890942.
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    25. Azarashvili T, Baburina Y, Grachev D, Krestinina O, Papadopoulos V, Lemasters JJ, Odinokova I, Reiser G. Carbenoxolone induces permeability transition pore opening in rat mitochondria via the translocator protein TSPO and connexin43. Arch Biochem Biophys. 2014 Sep 15; 558:87-94. PMID: 24995971; PMCID: PMC4547858.
    26. Aghazadeh Y, Martinez-Arguelles DB, Fan J, Culty M, Papadopoulos V. Induction of androgen formation in the male by a TAT-VDAC1 fusion peptide blocking 14-3-3? protein adaptor and mitochondrial VDAC1 interactions. Mol Ther. 2014 Oct; 22(10):1779-91. PMID: 24947306; PMCID: PMC4428399.
    27. Papadopoulos V. On the role of the translocator protein (18-kDa) TSPO in steroid hormone biosynthesis. Endocrinology. 2014 Jan; 155(1):15-20. PMID: 24364587.
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    28. Li J, Daly E, Campioli E, Wabitsch M, Papadopoulos V. De novo synthesis of steroids and oxysterols in adipocytes. J Biol Chem. 2014 Jan 10; 289(2):747-64. PMID: 24280213; PMCID: PMC3887202.
    29. Fan J, Papadopoulos V. Evolutionary origin of the mitochondrial cholesterol transport machinery reveals a universal mechanism of steroid hormone biosynthesis in animals. PLoS One. 2013; 8(10):e76701. PMID: 24124589; PMCID: PMC3790746.
    30. Gunosewoyo H, Midzak A, Gaisina IN, Sabath EV, Fedolak A, Hanania T, Brunner D, Papadopoulos V, Kozikowski AP. Characterization of maleimide-based glycogen synthase kinase-3 (GSK-3) inhibitors as stimulators of steroidogenesis. J Med Chem. 2013 Jun 27; 56(12):5115-29. PMID: 23725591; PMCID: PMC3777810.
    31. Beattie MC, Chen H, Fan J, Papadopoulos V, Miller P, Zirkin BR. Aging and luteinizing hormone effects on reactive oxygen species production and DNA damage in rat Leydig cells. Biol Reprod. 2013 Apr; 88(4):100. PMID: 23486914; PMCID: PMC4013884.
    32. Orlando U, Cooke M, Cornejo Maciel F, Papadopoulos V, Podestá EJ, Maloberti P. Characterization of the mouse promoter region of the acyl-CoA synthetase 4 gene: role of Sp1 and CREB. Mol Cell Endocrinol. 2013 Apr 30; 369(1-2):15-26. PMID: 23376217.
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    33. Issop L, Rone MB, Papadopoulos V. Organelle plasticity and interactions in cholesterol transport and steroid biosynthesis. Mol Cell Endocrinol. 2013 May 22; 371(1-2):34-46. PMID: 23246788.
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    34. Midzak A, Rammouz G, Papadopoulos V. Structure-activity relationship (SAR) analysis of a family of steroids acutely controlling steroidogenesis. Steroids. 2012 Nov; 77(13):1327-34. PMID: 22986075.
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    35. Rone MB, Midzak AS, Issop L, Rammouz G, Jagannathan S, Fan J, Ye X, Blonder J, Veenstra T, Papadopoulos V. Identification of a dynamic mitochondrial protein complex driving cholesterol import, trafficking, and metabolism to steroid hormones. Mol Endocrinol. 2012 Nov; 26(11):1868-82. PMID: 22973050.
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    36. Wang HJ, Fan J, Papadopoulos V. Translocator protein (Tspo) gene promoter-driven green fluorescent protein synthesis in transgenic mice: an in vivo model to study Tspo transcription. Cell Tissue Res. 2012 Nov; 350(2):261-75. PMID: 22868914; PMCID: PMC3740157.
    37. Fan J, Papadopoulos V. Transcriptional regulation of translocator protein (Tspo) via a SINE B2-mediated natural antisense transcript in MA-10 Leydig cells. Biol Reprod. 2012 May; 86(5):147, 1-15. PMID: 22378763; PMCID: PMC3364927.
    38. Akula N, Midzak A, Lecanu L, Papadopoulos V. Identification of small-molecule inhibitors of the steroidogenic acute regulatory protein (STARD1) by structure-based design. Bioorg Med Chem Lett. 2012 Jun 15; 22(12):4139-43. PMID: 22575868.
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    39. Campioli E, Batarseh A, Li J, Papadopoulos V. The endocrine disruptor mono-(2-ethylhexyl) phthalate affects the differentiation of human liposarcoma cells (SW 872). PLoS One. 2011; 6(12):e28750. PMID: 22205965; PMCID: PMC3244402.
    40. Stanley EL, Johnston DS, Fan J, Papadopoulos V, Chen H, Ge RS, Zirkin BR, Jelinsky SA. Stem Leydig cell differentiation: gene expression during development of the adult rat population of Leydig cells. Biol Reprod. 2011 Dec; 85(6):1161-6. PMID: 21832170; PMCID: PMC3223250.
    41. Castillo AF, Fan J, Papadopoulos V, Podestá EJ. Hormone-dependent expression of a steroidogenic acute regulatory protein natural antisense transcript in MA-10 mouse tumor Leydig cells. PLoS One. 2011; 6(8):e22822. PMID: 21829656; PMCID: PMC3148237.
    42. Midzak AS, Chen H, Aon MA, Papadopoulos V, Zirkin BR. ATP synthesis, mitochondrial function, and steroid biosynthesis in rodent primary and tumor Leydig cells. Biol Reprod. 2011 May; 84(5):976-85. PMID: 21228212; PMCID: PMC3080423.
    43. Midzak A, Akula N, Lecanu L, Papadopoulos V. Novel androstenetriol interacts with the mitochondrial translocator protein and controls steroidogenesis. J Biol Chem. 2011 Mar 18; 286(11):9875-87. PMID: 21209087; PMCID: PMC3058962.
    44. Midzak A, Rone M, Aghazadeh Y, Culty M, Papadopoulos V. Mitochondrial protein import and the genesis of steroidogenic mitochondria. Mol Cell Endocrinol. 2011 Apr 10; 336(1-2):70-9. PMID: 21147195; PMCID: PMC3057322.
    45. Rupprecht R, Papadopoulos V, Rammes G, Baghai TC, Fan J, Akula N, Groyer G, Adams D, Schumacher M. Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders. Nat Rev Drug Discov. 2010 Dec; 9(12):971-88. PMID: 21119734.
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    46. Ostuni MA, Issop L, Péranzi G, Walker F, Fasseu M, Elbim C, Papadopoulos V, Lacapere JJ. Overexpression of translocator protein in inflammatory bowel disease: potential diagnostic and treatment value. Inflamm Bowel Dis. 2010 Sep; 16(9):1476-87. PMID: 20222126; PMCID: PMC2930116.
    47. Fan J, Traore K, Li W, Amri H, Huang H, Wu C, Chen H, Zirkin B, Papadopoulos V. Molecular mechanisms mediating the effect of mono-(2-ethylhexyl) phthalate on hormone-stimulated steroidogenesis in MA-10 mouse tumor Leydig cells. Endocrinology. 2010 Jul; 151(7):3348-62. PMID: 20463053; PMCID: PMC2903930.
    48. Fan J, Liu J, Culty M, Papadopoulos V. Acyl-coenzyme A binding domain containing 3 (ACBD3; PAP7; GCP60): an emerging signaling molecule. Prog Lipid Res. 2010 Jul; 49(3):218-34. PMID: 20043945; PMCID: PMC2873055.
    49. Fan J, Rone MB, Papadopoulos V. Translocator protein 2 is involved in cholesterol redistribution during erythropoiesis. J Biol Chem. 2009 Oct 30; 284(44):30484-97. PMID: 19729679; PMCID: PMC2781603.
    50. Xu J, Lecanu L, Tan M, Greeson J, Papadopoulos V. Identification of a benzamide derivative that inhibits stress-induced adrenal corticosteroid synthesis. Molecules. 2009 Sep 03; 14(9):3392-410. PMID: 19783933.
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    51. Ostuni MA, Péranzi G, Ducroc RA, Fasseu M, Vidic B, Dumont J, Papadopoulos V, Lacapere JJ. Distribution, pharmacological characterization and function of the 18 kDa translocator protein in rat small intestine. Biol Cell. 2009 Jul 31; 101(10):573-86. PMID: 19392661.
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    52. Chapalain A, Chevalier S, Orange N, Murillo L, Papadopoulos V, Feuilloley MG. Bacterial ortholog of mammalian translocator protein (TSPO) with virulence regulating activity. PLoS One. 2009 Jun 30; 4(6):e6096. PMID: 19564920; PMCID: PMC2699550.
    53. Rone MB, Fan J, Papadopoulos V. Cholesterol transport in steroid biosynthesis: role of protein-protein interactions and implications in disease states. Biochim Biophys Acta. 2009 Jul; 1791(7):646-58. PMID: 19286473; PMCID: PMC2757135.
    54. Midzak AS, Chen H, Papadopoulos V, Zirkin BR. Leydig cell aging and the mechanisms of reduced testosterone synthesis. Mol Cell Endocrinol. 2009 Feb 05; 299(1):23-31. PMID: 18761053.
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    55. Ostuni MA, Tumilasci OR, Péranzi G, Cardoso EM, Contreras LN, Arregger AL, Papadopoulos V, Lacapere JJ. Effect of translocator protein (18 kDa)-ligand binding on neurotransmitter-induced salivary secretion in rat submandibular glands. Biol Cell. 2008 Jul; 100(7):427-39. PMID: 18269350.
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    56. Culty M, Thuillier R, Li W, Wang Y, Martinez-Arguelles DB, Benjamin CG, Triantafilou KM, Zirkin BR, Papadopoulos V. In utero exposure to di-(2-ethylhexyl) phthalate exerts both short-term and long-lasting suppressive effects on testosterone production in the rat. Biol Reprod. 2008 Jun; 78(6):1018-28. PMID: 18322279.
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    57. Veenman L, Papadopoulos V, Gavish M. Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response. Curr Pharm Des. 2007; 13(23):2385-405. PMID: 17692008.
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    58. Azarashvili T, Grachev D, Krestinina O, Evtodienko Y, Yurkov I, Papadopoulos V, Reiser G. The peripheral-type benzodiazepine receptor is involved in control of Ca2+-induced permeability transition pore opening in rat brain mitochondria. Cell Calcium. 2007 Jul; 42(1):27-39. PMID: 17174393.
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    59. Zhang K, Demeure O, Belliard A, Goujon JM, Favreau F, Desurmont T, Mauco G, Barrière M, Carretier M, Milan D, Papadopoulos V, Hauet T. Cloning, sequencing, and chromosomal localization of pig peripheral benzodiazepine receptor: three different forms produced by alternative splicing. Mamm Genome. 2006 Oct; 17(10):1050-62. PMID: 17019653.
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    60. Cheah JH, Kim SF, Hester LD, Clancy KW, Patterson SE, Papadopoulos V, Snyder SH. NMDA receptor-nitric oxide transmission mediates neuronal iron homeostasis via the GTPase Dexras1. Neuron. 2006 Aug 17; 51(4):431-40. PMID: 16908409; PMCID: PMC3150500.
    61. Papadopoulos V, Baraldi M, Guilarte TR, Knudsen TB, Lacapère JJ, Lindemann P, Norenberg MD, Nutt D, Weizman A, Zhang MR, Gavish M. Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci. 2006 Aug; 27(8):402-9. PMID: 16822554.
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    62. Jamin N, Neumann JM, Ostuni MA, Vu TK, Yao ZX, Murail S, Robert JC, Giatzakis C, Papadopoulos V, Lacapère JJ. Characterization of the cholesterol recognition amino acid consensus sequence of the peripheral-type benzodiazepine receptor. Mol Endocrinol. 2005 Mar; 19(3):588-94. PMID: 15528269.
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    63. Lindemann P, Koch A, Degenhardt B, Hause G, Grimm B, Papadopoulos V. A novel Arabidopsis thaliana protein is a functional peripheral-type benzodiazepine receptor. Plant Cell Physiol. 2004 Jun; 45(6):723-33. PMID: 15215507.
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    64. Amri H, Li W, Drieu K, Papadopoulos V. Identification of the adrenocorticotropin and ginkgolide B-regulated 90-kilodalton protein (p90) in adrenocortical cells as a serotransferrin precursor protein homolog (adrenotransferrin). Endocrinology. 2004 Apr; 145(4):1802-9. PMID: 14701678.
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    65. Wendler G, Lindemann P, Lacapère JJ, Papadopoulos V. Protoporphyrin IX binding and transport by recombinant mouse PBR. Biochem Biophys Res Commun. 2003 Nov 28; 311(4):847-52. PMID: 14623258.
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    66. Giatzakis C, Papadopoulos V. Differential utilization of the promoter of peripheral-type benzodiazepine receptor by steroidogenic versus nonsteroidogenic cell lines and the role of Sp1 and Sp3 in the regulation of basal activity. Endocrinology. 2004 Mar; 145(3):1113-23. PMID: 14630713.
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    67. Li W, Trovero F, Cordier J, Wang Y, Drieu K, Papadopoulos V. Prenatal exposure of rats to Ginkgo biloba extract (EGb 761) increases neuronal survival/growth and alters gene expression in the developing fetal hippocampus. Brain Res Dev Brain Res. 2003 Sep 10; 144(2):169-80. PMID: 12935914.
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    68. Liu J, Cavalli LR, Haddad BR, Papadopoulos V. Molecular cloning, genomic organization, chromosomal mapping and subcellular localization of mouse PAP7: a PBR and PKA-RIalpha associated protein. Gene. 2003 Apr 10; 308:1-10. PMID: 12711385.
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    69. Liu J, Matyakhina L, Han Z, Sandrini F, Bei T, Stratakis CA, Papadopoulos V. Molecular cloning, chromosomal localization of human peripheral-type benzodiazepine receptor and PKA regulatory subunit type 1A (PRKAR1A)-associated protein PAP7, and studies in PRKAR1A mutant cells and tissues. FASEB J. 2003 Jun; 17(9):1189-91. PMID: 12692076.
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    70. Gazouli M, Yao ZX, Boujrad N, Corton JC, Culty M, Papadopoulos V. Effect of peroxisome proliferators on Leydig cell peripheral-type benzodiazepine receptor gene expression, hormone-stimulated cholesterol transport, and steroidogenesis: role of the peroxisome proliferator-activator receptor alpha. Endocrinology. 2002 Jul; 143(7):2571-83. PMID: 12072389.
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    71. Culty M, Luo L, Yao ZX, Chen H, Papadopoulos V, Zirkin BR. Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells. J Androl. 2002 May-Jun; 23(3):439-47. PMID: 12002446.
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