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Mei Chen, PhD

Title(s)Professor of Dermatology
AddressNOR 5301 1441 Eastlake Avenue
Health Sciences Campus
Los Angeles CA 90089-9176
Phone+1 323 865 0621
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    Dr. Chen obtained a Ph.D. in Cell Biology, Virology and Molecular Biology at Albert Einstein College of Medicine in New York. After postdoctoral training in Cell and Developmental Biology at Memorial Sloan-Kettering Cancer Center and Cornell University Medical College, Dr. Chen joined the faculty of the department of Dermatology at Northwestern University Medical School, followed by an appointment at the University of Southern California where she is currently Professor and Director of USC Laboratories for Investigative Dermatology. Dr. Chen’s research has focused on elucidating the structure and function of type VII (anchoring fibril) collagen and developing various therapeutic approaches including cell therapy, small molecule-based drug therapy, protein therapy and gene therapy for the treatment of recessive dystrophic epidermolysis bullosa (RDEB). Her current research plans are 1) to evaluate the effects of recombinant type VII collagen (rC7) on skin wounds in normal and diabetic pigs. This is because it is known that pigskin is the most similar of all species to human skin. This will provide essential data for moving rC7 from the laboratory bench to the patient’s bedside; 2) To determine the signaling pathway(s) responsible for RDEB scarring and identify the mechanism(s) by which rC7 inhibits skin wound scar formation; this work may lead to insights into the pathology of scars and identifiable targets for agents to prevent skin scarring; 3) To evaluate aminoglycoside-based drug therapy for RDEB in human patients; and 4) To identify the changes in RDEB-associated squamous cell carcinoma (SCC) at the cellular and molecular levels and elucidate signaling pathways leading to onset of RDEB SCC that may provide targets for anti-SCC drug development. All of these studies have strong translational potential and will hopefully advance future therapies for patients with RDEB, patients with devastating scarring conditions (burn victims, RDEB patients, keloids, chronic graft-versus-host disease, scleroderma, and others), and patients with chronic non-healing wounds (diabetic ulcers, decubitus ulcers and stasis dermatitis ulcers). The entirety of her work will generate novel insights into cutaneous biology and has great translational potential towards bringing rC7 “from the laboratory bench to the bedside of patients”. Our research programs have been continuously supported by NIH grants for the last twenty years.

    Collapse Research 
    Collapse Research Activities and Funding
    A Pilot Study of the Effect of Intravenous Gentamicin on the Restoration of Full-Length Type VII Collagen in RDEB Patients Carrying Nonsense Mutations
    NIH/NIAMS R21AR071716Mar 1, 2018 - Feb 28, 2020
    Role: Principal Investigator
    Protein Therapy for Recessive Dystrophic Epidermolysis Bullosa
    NIH/NIAMS RC4AR060535Sep 20, 2010 - Sep 30, 2013
    Role: Principal Investigator
    Strategies Towards Gene Therapy for Dystrophic Epidermolysis Bullosa
    NIH/NIAMS R01AR047981Aug 1, 2001 - May 31, 2005
    Role: Principal Investigator
    Purification of Epidermolysis Bullosa Antigen
    NIH/NIAMS R01AR033625Apr 1, 1984 - Sep 28, 2008
    Role: Co-Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Suppression of TGFß and Angiogenesis by Type VII Collagen in Cutaneous SCC. J Natl Cancer Inst. 2016 Jan; 108(1). Martins VL, Caley MP, Moore K, Szentpetery Z, Marsh ST, Murrell DF, Kim MH, Avari M, McGrath JA, Cerio R, Kivisaari A, Kähäri VM, Hodivala-Dilke K, Brennan CH, Chen M, Marshall JF, O'Toole EA. PMID: 26476432.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    2. Lentiviral Engineered Fibroblasts Expressing Codon Optimized COL7A1 Restore Anchoring Fibrils in RDEB. J Invest Dermatol. 2015 Sep 22. Georgiadis C, Syed F, Petrova A, Abdul-Wahab A, Lwin SM, Farzaneh F, Chan L, Ghani S, Fleck RA, Glover L, McMillan JR, Chen M, Thrasher AJ, McGrath JA, Di WL, Qasim W. PMID: 26394110.
      View in: PubMed   Mentions:
    3. A Novel Fully Humanized 3D Skin Equivalent to Model Early Melanoma Invasion. Mol Cancer Ther. 2015 Nov; 14(11):2665-73. Hill DS, Robinson ND, Caley MP, Chen M, O'Toole EA, Armstrong JL, Przyborski S, Lovat PE. PMID: 26330548.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    4. Intravenously Administered Recombinant Human Type VII Collagen Derived from Chinese Hamster Ovary Cells Reverses the Disease Phenotype in Recessive Dystrophic Epidermolysis Bullosa Mice. J Invest Dermatol. 2015 Dec; 135(12):3060-3067. Hou Y, Guey LT, Wu T, Gao R, Cogan J, Wang X, Hong E, Vivian Ning W, Keene D, Liu N, Huang Y, Kaftan C, Tangarone B, Quinones-Garcia I, Uitto J, Francone OL, Woodley DT, Chen M. PMID: 26203639.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    5. Reduced Toxicity Conditioning and Allogeneic Hematopoietic Progenitor Cell Transplantation for Recessive Dystrophic Epidermolysis Bullosa. J Pediatr. 2015 Sep; 167(3):765-9.e1. Geyer MB, Radhakrishnan K, Giller R, Umegaki N, Harel S, Kiuru M, Morel KD, LeBoeuf N, Kandel J, Bruckner A, Fabricatore S, Chen M, Woodley D, McGrath J, Baxter-Lowe L, Uitto J, Christiano AM, Cairo MS. PMID: 26148662.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    6. Recessive Dystrophic Epidermolysis Bullosa: Advances in the Laboratory Leading to New Therapies. J Invest Dermatol. 2015 Jul; 135(7):1705-1707. Woodley DT, Chen M. PMID: 26066885.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    7. Keratinocyte Migration and a Hypothetical New Role for Extracellular Heat Shock Protein 90 Alpha in Orchestrating Skin Wound Healing. Adv Wound Care (New Rochelle). 2015 Apr 01; 4(4):203-212. Woodley DT, Wysong A, DeClerck B, Chen M, Li W. PMID: 25945283.
      View in: PubMed   Mentions:
    8. Hsp90a and Hsp90ß together operate a hypoxia and nutrient paucity stress-response mechanism during wound healing. J Cell Sci. 2015 Apr 15; 128(8):1475-80. Jayaprakash P, Dong H, Zou M, Bhatia A, O'Brien K, Chen M, Woodley DT, Li W. PMID: 25736295.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    9. Identification of the critical therapeutic entity in secreted Hsp90a that promotes wound healing in newly re-standardized healthy and diabetic pig models. PLoS One. 2014; 9(12):e113956. O'Brien K, Bhatia A, Tsen F, Chen M, Wong AK, Woodley DT, Li W. PMID: 25464502.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    10. Aminoglycosides restore full-length type VII collagen by overcoming premature termination codons: therapeutic implications for dystrophic epidermolysis bullosa. Mol Ther. 2014 Oct; 22(10):1741-52. Cogan J, Weinstein J, Wang X, Hou Y, Martin S, South AP, Woodley DT, Chen M. PMID: 25155989.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    11. De novo anti-type VII collagen antibodies in patients with recessive dystrophic epidermolysis bullosa. J Invest Dermatol. 2014 Apr; 134(4):1138-1140. Woodley DT, Cogan J, Wang X, Hou Y, Haghighian C, Kudo G, Keene DR, Chen M. PMID: 24213372.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    12. Extracellular heat shock protein 90 signals through subdomain II and the NPVY motif of LRP-1 receptor to Akt1 and Akt2: a circuit essential for promoting skin cell migration in vitro and wound healing in vivo. Mol Cell Biol. 2013 Dec; 33(24):4947-59. Tsen F, Bhatia A, O'Brien K, Cheng CF, Chen M, Hay N, Stiles B, Woodley DT, Li W. PMID: 24126057.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    13. Topical application of recombinant type VII collagen incorporates into the dermal-epidermal junction and promotes wound closure. Mol Ther. 2013 Jul; 21(7):1335-44. Wang X, Ghasri P, Amir M, Hwang B, Hou Y, Khalili M, Khilili M, Lin A, Keene D, Uitto J, Woodley DT, Chen M. PMID: 23670575.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    14. Intravenously injected recombinant human type VII collagen homes to skin wounds and restores skin integrity of dystrophic epidermolysis bullosa. J Invest Dermatol. 2013 Jul; 133(7):1910-3. Woodley DT, Wang X, Amir M, Hwang B, Remington J, Hou Y, Uitto J, Keene D, Chen M. PMID: 23321924.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    15. Extracellular Hsp90 (eHsp90) as the actual target in clinical trials: intentionally or unintentionally. Int Rev Cell Mol Biol. 2013; 303:203-35. Li W, Tsen F, Sahu D, Bhatia A, Chen M, Multhoff G, Woodley DT. PMID: 23445811.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    16. The anti-motility signaling mechanism of TGFß3 that controls cell traffic during skin wound healing. Biol Open. 2012 Dec 15; 1(12):1169-77. Han A, Bandyopadhyay B, Jayaprakash P, Lua I, Sahu D, Chen M, Woodley DT, Li W. PMID: 23259050.
      View in: PubMed   Mentions:
    17. Epidermolysis bullosa acquisita. Clin Dermatol. 2012 Jan-Feb; 30(1):60-9. Gupta R, Woodley DT, Chen M. PMID: 22137228.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    18. A potentially common peptide target in secreted heat shock protein-90a for hypoxia-inducible factor-1a-positive tumors. Mol Biol Cell. 2012 Feb; 23(4):602-13. Sahu D, Zhao Z, Tsen F, Cheng CF, Park R, Situ AJ, Dai J, Eginli A, Shams S, Chen M, Ulmer TS, Conti P, Woodley DT, Li W. PMID: 22190738.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    19. A fragment of secreted Hsp90a carries properties that enable it to accelerate effectively both acute and diabetic wound healing in mice. J Clin Invest. 2011 Nov; 121(11):4348-61. Cheng CF, Sahu D, Tsen F, Zhao Z, Fan J, Kim R, Wang X, O'Brien K, Li Y, Kuang Y, Chen M, Woodley DT, Li W. PMID: 22019588.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    20. Epidermolysis bullosa acquisita: autoimmunity to anchoring fibril collagen. Autoimmunity. 2012 Feb; 45(1):91-101. Chen M, Kim GH, Prakash L, Woodley DT. PMID: 21955050.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    21. TbetaRI/Alk5-independent TbetaRII signaling to ERK1/2 in human skin cells according to distinct levels of TbetaRII expression. J Cell Sci. 2011 Jan 01; 124(Pt 1):19-24. Bandyopadhyay B, Han A, Dai J, Fan J, Li Y, Chen M, Woodley DT, Li W. PMID: 21172820.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    22. Congenital epidermolysis bullosa acquisita: vertical transfer of maternal autoantibody from mother to infant. Arch Dermatol. 2011 Mar; 147(3):337-41. Abrams ML, Smidt A, Benjamin L, Chen M, Woodley D, Mancini AJ. PMID: 21079052.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    23. Bone marrow transplantation for recessive dystrophic epidermolysis bullosa. N Engl J Med. 2010 Aug 12; 363(7):629-39. Wagner JE, Ishida-Yamamoto A, McGrath JA, Hordinsky M, Keene DR, Woodley DT, Chen M, Riddle MJ, Osborn MJ, Lund T, Dolan M, Blazar BR, Tolar J. PMID: 20818854.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCTClinical Trials
    24. Participation of the lipoprotein receptor LRP1 in hypoxia-HSP90alpha autocrine signaling to promote keratinocyte migration. J Cell Sci. 2009 May 15; 122(Pt 10):1495-8. Woodley DT, Fan J, Cheng CF, Li Y, Chen M, Bu G, Li W. PMID: 19383717.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    25. TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites. Cell. 2009 Mar 06; 136(5):891-902. Saito K, Chen M, Bard F, Chen S, Zhou H, Woodley D, Polischuk R, Schekman R, Malhotra V. PMID: 19269366.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansAnimalsCells
    26. Non-compensating roles between Nckalpha and Nckbeta in PDGF-BB signaling to promote human dermal fibroblast migration. J Invest Dermatol. 2009 Aug; 129(8):1909-20. Guan S, Fan J, Han A, Chen M, Woodley DT, Li W. PMID: 19242519.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    27. Familial epidermolysis bullosa acquisita. Dermatol Online J. 2008 Dec 15; 14(12):2. Noe MH, Chen M, Woodley DT, Fairley JA. PMID: 19265615.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    28. Injection of recombinant human type VII collagen corrects the disease phenotype in a murine model of dystrophic epidermolysis bullosa. Mol Ther. 2009 Jan; 17(1):26-33. Remington J, Wang X, Hou Y, Zhou H, Burnett J, Muirhead T, Uitto J, Keene DR, Woodley DT, Chen M. PMID: 19018253.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
    29. Duplicating autoimmune bullous diseases by passively transferring autoantibodies into animals. J Invest Dermatol. 2008 Oct 06; 128(E3):E25-7. Chen M, Woodley DT. PMID: 21233826.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    30. Characterization of molecular mechanisms underlying mutations in dystrophic epidermolysis bullosa using site-directed mutagenesis. J Biol Chem. 2008 Jun 27; 283(26):17838-45. Woodley DT, Hou Y, Martin S, Li W, Chen M. PMID: 18450758.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    31. Transforming growth factor alpha (TGFalpha)-stimulated secretion of HSP90alpha: using the receptor LRP-1/CD91 to promote human skin cell migration against a TGFbeta-rich environment during wound healing. Mol Cell Biol. 2008 May; 28(10):3344-58. Cheng CF, Fan J, Fedesco M, Guan S, Li Y, Bandyopadhyay B, Bright AM, Yerushalmi D, Liang M, Chen M, Han YP, Woodley DT, Li W. PMID: 18332123.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCells
    32. Profiling motility signal-specific genes in primary human keratinocytes. J Invest Dermatol. 2008 Aug; 128(8):1981-90. Cheng CF, Fan J, Bandyopahdhay B, Mock D, Guan S, Chen M, Woodley DT, Li W. PMID: 18323786.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    33. Hypoxia induces epidermal keratinocyte matrix metalloproteinase-9 secretion via the protein kinase C pathway. J Cell Physiol. 2008 Jan; 214(1):47-55. O'Toole EA, van Koningsveld R, Chen M, Woodley DT. PMID: 17559070.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    34. Autoimmunity to type VII collagen: epidermolysis bullosa acquisita. Curr Dir Autoimmun. 2008; 10:195-205. Remington J, Chen M, Burnett J, Woodley DT. PMID: 18460887.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    35. Autoimmunity to type VII collagen: epidermolysis bullosa acquisita. Clin Rev Allergy Immunol. 2007 Oct; 33(1-2):78-84. Woodley DT, Remington J, Chen M. PMID: 18058258.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    36. Nckbeta adapter controls neuritogenesis by maintaining the cellular paxillin level. Mol Cell Biol. 2007 Sep; 27(17):6001-11. Guan S, Chen M, Woodley D, Li W. PMID: 17591694.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    37. The cartilage matrix protein subdomain of type VII collagen is pathogenic for epidermolysis bullosa acquisita. Am J Pathol. 2007 Jun; 170(6):2009-18. Chen M, Doostan A, Bandyopadhyay P, Remington J, Wang X, Hou Y, Liu Z, Woodley DT. PMID: 17525268.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    38. Extracellular heat shock protein-90alpha: linking hypoxia to skin cell motility and wound healing. EMBO J. 2007 Mar 07; 26(5):1221-33. Li W, Li Y, Guan S, Fan J, Cheng CF, Bright AM, Chinn C, Chen M, Woodley DT. PMID: 17304217.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    39. Intravenously injected human fibroblasts home to skin wounds, deliver type VII collagen, and promote wound healing. Mol Ther. 2007 Mar; 15(3):628-35. Woodley DT, Remington J, Huang Y, Hou Y, Li W, Keene DR, Chen M. PMID: 17245357.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    40. PKCdelta clustering at the leading edge and mediating growth factor-enhanced, but not ecm-initiated, dermal fibroblast migration. J Invest Dermatol. 2006 Jun; 126(6):1233-43. Fan J, Guan S, Cheng CF, Cho M, Fields JW, Chen M, Denning MF, Woodley DT, Li W. PMID: 16543902.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    41. Induction of epidermolysis bullosa acquisita in mice by passive transfer of autoantibodies from patients. J Invest Dermatol. 2006 Jun; 126(6):1323-30. Woodley DT, Ram R, Doostan A, Bandyopadhyay P, Huang Y, Remington J, Hou Y, Keene DR, Liu Z, Chen M. PMID: 16543893.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    42. Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration. J Invest Dermatol. 2006 Sep; 126(9):2096-105. Li Y, Fan J, Chen M, Li W, Woodley DT. PMID: 16691197.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    43. Fibroblasts as target cells for DEB gene therapy. J Invest Dermatol. 2006 Apr; 126(4):708-10. Chen M, Woodley DT. PMID: 16541096.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    44. A "traffic control" role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healing. J Cell Biol. 2006 Mar 27; 172(7):1093-105. Bandyopadhyay B, Fan J, Guan S, Li Y, Chen M, Woodley DT, Li W. PMID: 16549496.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    45. Evidence that anti-type VII collagen antibodies are pathogenic and responsible for the clinical, histological, and immunological features of epidermolysis bullosa acquisita. J Invest Dermatol. 2005 May; 124(5):958-64. Woodley DT, Chang C, Saadat P, Ram R, Liu Z, Chen M. PMID: 15854036.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    46. Wound-healing perspectives. Dermatol Clin. 2005 Apr; 23(2):181-92. Li W, Dasgeb B, Phillips T, Li Y, Chen M, Garner W, Woodley DT. PMID: 15837149.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    47. Signals that initiate, augment, and provide directionality for human keratinocyte motility. J Invest Dermatol. 2004 Oct; 123(4):622-33. Li W, Henry G, Fan J, Bandyopadhyay B, Pang K, Garner W, Chen M, Woodley DT. PMID: 15373765.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    48. Mechanisms of human skin cell motility. Histol Histopathol. 2004 10; 19(4):1311-24. Li W, Fan J, Chen M, Woodley DT. PMID: 15375774.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    49. Intradermal injection of lentiviral vectors corrects regenerated human dystrophic epidermolysis bullosa skin tissue in vivo. Mol Ther. 2004 Aug; 10(2):318-26. Woodley DT, Keene DR, Atha T, Huang Y, Ram R, Kasahara N, Chen M. PMID: 15294178.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    50. Epidermolysis bullosa: then and now. J Am Acad Dermatol. 2004 Jul; 51(1 Suppl):S55-7. Woodley DT, Chen M. PMID: 15243513.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    51. A patient with both bullous pemphigoid and epidermolysis bullosa acquisita: an example of intermolecular epitope spreading. J Am Acad Dermatol. 2004 Jul; 51(1):118-22. Fairley JA, Woodley DT, Chen M, Giudice GJ, Lin MS. PMID: 15243536.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    52. Injection of recombinant human type VII collagen restores collagen function in dystrophic epidermolysis bullosa. Nat Med. 2004 Jul; 10(7):693-5. Woodley DT, Keene DR, Atha T, Huang Y, Lipman K, Li W, Chen M. PMID: 15195089.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimals
    53. Normal and gene-corrected dystrophic epidermolysis bullosa fibroblasts alone can produce type VII collagen at the basement membrane zone. J Invest Dermatol. 2003 Nov; 121(5):1021-8. Woodley DT, Krueger GG, Jorgensen CM, Fairley JA, Atha T, Huang Y, Chan L, Keene DR, Chen M. PMID: 14708601.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    54. Mechanism of human dermal fibroblast migration driven by type I collagen and platelet-derived growth factor-BB. Mol Biol Cell. 2004 Jan; 15(1):294-309. Li W, Fan J, Chen M, Guan S, Sawcer D, Bokoch GM, Woodley DT. PMID: 14595114.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    55. An efficient gene transduction system for studying gene function in primary human dermal fibroblasts and epidermal keratinocytes. Clin Exp Dermatol. 2003 Mar; 28(2):193-9. Chen M, Li W, Fan J, Kasahara N, Woodley D. PMID: 12653712.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    56. Restoration of type VII collagen expression and function in dystrophic epidermolysis bullosa. Nat Genet. 2002 Dec; 32(4):670-5. Chen M, Kasahara N, Keene DR, Chan L, Hoeffler WK, Finlay D, Barcova M, Cannon PM, Mazurek C, Woodley DT. PMID: 12426566.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    57. The epidermolysis bullosa acquisita antigen (type VII collagen) is present in human colon and patients with crohn's disease have autoantibodies to type VII collagen. J Invest Dermatol. 2002 Jun; 118(6):1059-64. Chen M, O'Toole EA, Sanghavi J, Mahmud N, Kelleher D, Weir D, Fairley JA, Woodley DT. PMID: 12060403.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    58. Drug-induced epidermolysis bullosa acquisita with antibodies to type VII collagen. J Am Acad Dermatol. 2002 May; 46(5 Suppl):S161-4. Delbaldo C, Chen M, Friedli A, Prins C, Desmeules J, Saurat JH, Woodley DT, Borradori L. PMID: 12004302.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    59. An important role for protein kinase C-delta in human keratinocyte migration on dermal collagen. Exp Cell Res. 2002 Feb 15; 273(2):219-28. Li W, Nadelman C, Gratch NS, Li W, Chen M, Kasahara N, Woodley DT. PMID: 11822877.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    60. The p38-MAPK/SAPK pathway is required for human keratinocyte migration on dermal collagen. J Invest Dermatol. 2001 Dec; 117(6):1601-11. Li W, Nadelman C, Henry G, Fan J, Muellenhoff M, Medina E, Gratch NS, Chen M, Han J, Woodley D. PMID: 11886529.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    61. The recombinant expression of full-length type VII collagen and characterization of molecular mechanisms underlying dystrophic epidermolysis bullosa. J Biol Chem. 2002 Jan 18; 277(3):2118-24. Chen M, Costa FK, Lindvay CR, Han YP, Woodley DT. PMID: 11698408.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    62. Epidermolysis bullosa acquisita: update and review. Clin Dermatol. 2001 Nov-Dec; 19(6):712-8. Hallel-Halevy D, Nadelman C, Chen M, Woodley DT. PMID: 11705680.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    63. The carboxyl terminus of type VII collagen mediates antiparallel dimer formation and constitutes a new antigenic epitope for epidermolysis Bullosa acquisita autoantibodies. J Biol Chem. 2001 Jun 15; 276(24):21649-55. Chen M, Keene DR, Costa FK, Tahk SH, Woodley DT. PMID: 11274208.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    64. Autoantibodies to type VII collagen have heterogeneous subclass and light chain compositions and their complement-activating capacities do not correlate with the inflammatory clinical phenotype. J Clin Immunol. 2000 Nov; 20(6):416-23. Gandhi K, Chen M, Aasi S, Lapiere JC, Woodley DT, Chan LS. PMID: 11202231.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    65. Nckbeta adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to platelet-derived growth factor bb. Mol Cell Biol. 2000 Nov; 20(21):7867-80. Chen M, She H, Kim A, Woodley DT, Li W. PMID: 11027258.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    66. Development and characterization of a recombinant truncated type VII collagen "minigene". Implication for gene therapy of dystrophic epidermolysis bullosa. J Biol Chem. 2000 Aug 11; 275(32):24429-35. Chen M, O'Toole EA, Muellenhoff M, Medina E, Kasahara N, Woodley DT. PMID: 10821839.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    67. Alpha 2 beta 1 integrin mediates dermal fibroblast attachment to type VII collagen via a 158-amino-acid segment of the NC1 domain. Exp Cell Res. 1999 Jun 15; 249(2):231-9. Chen M, O'Toole EA, Li YY, Woodley DT. PMID: 10366422.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    68. Bullous systemic lupus erythematosus with autoantibodies recognizing multiple skin basement membrane components, bullous pemphigoid antigen 1, laminin-5, laminin-6, and type VII collagen. Arch Dermatol. 1999 May; 135(5):569-73. Chan LS, Lapiere JC, Chen M, Traczyk T, Mancini AJ, Paller AS, Woodley DT, Marinkovich MP. PMID: 10328198.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    69. NC1 domain of type VII collagen binds to the beta3 chain of laminin 5 via a unique subdomain within the fibronectin-like repeats. J Invest Dermatol. 1999 Feb; 112(2):177-83. Chen M, Marinkovich MP, Jones JC, O'Toole EA, Li YY, Woodley DT. PMID: 9989793.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    70. Molecular cloning and characterization of a cDNA encoding canine type VII collagen non-collagenous (NC1) domain, the target antigen of autoimmune disease epidermolysis bullosa acquisita (EBA). Biochim Biophys Acta. 1998 Oct 22; 1408(1):25-34. Xu L, Chen M, Peng J, O'Toole EA, Woodley DT, Chan LS. PMID: 9784596.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    71. Epitope spreading: lessons from autoimmune skin diseases. J Invest Dermatol. 1998 Feb; 110(2):103-9. Chan LS, Vanderlugt CJ, Hashimoto T, Nishikawa T, Zone JJ, Black MM, Wojnarowska F, Stevens SR, Chen M, Fairley JA, Woodley DT, Miller SD, Gordon KB. PMID: 9457902.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    72. Interactions of the amino-terminal noncollagenous (NC1) domain of type VII collagen with extracellular matrix components. A potential role in epidermal-dermal adherence in human skin. J Biol Chem. 1997 Jun 06; 272(23):14516-22. Chen M, Marinkovich MP, Veis A, Cai X, Rao CN, O'Toole EA, Woodley DT. PMID: 9169408.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    73. Laminin-6 and laminin-5 are recognized by autoantibodies in a subset of cicatricial pemphigoid. J Invest Dermatol. 1997 Jun; 108(6):848-53. Chan LS, Majmudar AA, Tran HH, Meier F, Schaumburg-Lever G, Chen M, Anhalt G, Woodley DT, Marinkovich MP. PMID: 9182809.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    74. Modulation of type VII collagen (anchoring fibril) expression by retinoids in human skin cells. Biochim Biophys Acta. 1997 Apr 10; 1351(3):333-40. Chen M, Goyal S, Cai X, O'Toole EA, Woodley DT. PMID: 9130597.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    75. Ultraviolet A irradiation upregulates type VII collagen expression in human dermal fibroblasts. J Invest Dermatol. 1997 Feb; 108(2):125-8. Chen M, Petersen MJ, Li HL, Cai XY, O'Toole EA, Woodley DT. PMID: 9008222.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    76. Development of an ELISA for rapid detection of anti-type VII collagen autoantibodies in epidermolysis bullosa acquisita. J Invest Dermatol. 1997 Jan; 108(1):68-72. Chen M, Chan LS, Cai X, O'Toole EA, Sample JC, Woodley DT. PMID: 8980290.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
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