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Noah Malmstadt, PhD

TitleAssociate Professor
InstitutionUniversity of Southern California
DepartmentEngineering
AddressRTH 504
University Park Campus
Los Angeles CA 90089-1211
Phone+1 213 821 2034
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    Noah Malmstadt received a BS in Chemical Engineering from Caltech and a PhD in Bioengineering from the University of Washington. Following postdoctoral work at UCLA, he joined the Mork Family Department of Chemical Engineering and Materials Science at USC in 2007. His research focuses on synthetic cell membrane systems and multiphase microfluidic strategies for nanofabrication. He is the recipient of an Office of Naval Research Young Investigator award. His work in engineering education focuses on integrating team-based design projects into the core chemical engineering curriculum.


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    A Target-Directed Reagent Pipeline via Microfluidic mRNA Display
    NIH/NCI R21CA204708May 23, 2017 - Apr 30, 2020
    Role: Principal Investigator
    Connecting plasma membrane function to lipid structure and organization with asym
    NIH/NIGMS R01GM093279Sep 30, 2010 - Jul 31, 2015
    Role: Principal Investigator
    Biomimetic Systems for Studying Nanoscale Structure Formation in Cell Membranes
    NIH/NIA R21AG033890May 1, 2009 - Apr 30, 2012
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Thompson B, Movsesian N, Cheng C, Karandikar P, Gupta M, Malmstadt N. Modular microfluidics for double emulsion formation. Methods Cell Biol. 2018; 148:161-176. PMID: 30473068.
      View in: PubMed
    2. Movsesian N, Tittensor M, Dianat G, Gupta M, Malmstadt N. Giant Lipid Vesicle Formation Using Vapor-Deposited Charged Porous Polymers. Langmuir. 2018 Jul 02. PMID: 29961336.
      View in: PubMed
    3. Mora NL, Gao Y, Gutierrez MG, Peruzzi J, Bakker I, Peters RJRW, Siewert B, Bonnet S, Kieltyka RE, van Hest JCM, Malmstadt N, Kros A. Evaluation of dextran(ethylene glycol) hydrogel films for giant unilamellar lipid vesicle production and their application for the encapsulation of polymersomes. Soft Matter. 2017 Aug 23; 13(33):5580-5588. PMID: 28730206.
      View in: PubMed
    4. Peruzzi J, Gutierrez MG, Mansfield K, Malmstadt N. Dynamics of Hydrogel-Assisted Giant Unilamellar Vesicle Formation from Unsaturated Lipid Systems. Langmuir. 2016 Dec 06; 32(48):12702-12709. PMID: 27934517.
      View in: PubMed
    5. Gutierrez MG, Jalali-Yazdi F, Peruzzi J, Riche CT, Roberts RW, Malmstadt N. G Protein-Coupled Receptors Incorporated into Rehydrated Diblock Copolymer Vesicles Retain Functionality. Small. 2016 Oct; 12(38):5256-5260. PMID: 27529518.
      View in: PubMed
    6. Gutierrez MG, Mansfield KS, Malmstadt N. The Functional Activity of the Human Serotonin 5-HT1A Receptor Is Controlled by Lipid Bilayer Composition. Biophys J. 2016 Jun 07; 110(11):2486-2495. PMID: 27276266; PMCID: PMC4922583 [Available on 06/07/17].
    7. Sankhagowit S, Lee EY, Wong GC, Malmstadt N. Oxidation of Membrane Curvature-Regulating Phosphatidylethanolamine Lipid Results in Formation of Bilayer and Cubic Structures. Langmuir. 2016 Mar 15; 32(10):2450-7. PMID: 26866900.
      View in: PubMed
    8. Riche CT, Roberts EJ, Gupta M, Brutchey RL, Malmstadt N. Flow invariant droplet formation for stable parallel microreactors. Nat Commun. 2016 Feb 23; 7:10780. PMID: 26902825; PMCID: PMC4766398.
    9. Bhargava KC, Thompson B, Tembhekar A, Malmstadt N. Temperature Sensing in Modular Microfluidic Architectures. Micromachines (Basel). 2016 Jan 18; 7(1). PMID: 30407384.
      View in: PubMed
    10. Runas KA, Acharya SJ, Schmidt JJ, Malmstadt N. Addition of Cleaved Tail Fragments during Lipid Oxidation Stabilizes Membrane Permeability Behavior. Langmuir. 2016 Jan 26; 32(3):779-86. PMID: 26704691.
      View in: PubMed
    11. Bhargava KC, Thompson B, Iqbal D, Malmstadt N. Predicting the behavior of microfluidic circuits made from discrete elements. Sci Rep. 2015 Oct 30; 5:15609. PMID: 26516059; PMCID: PMC4626777.
    12. Kegulian NC, Sankhagowit S, Apostolidou M, Jayasinghe SA, Malmstadt N, Butler PC, Langen R. Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption. J Biol Chem. 2015 Oct 23; 290(43):25782-93. PMID: 26283787; PMCID: PMC4646232 [Available on 10/23/16].
    13. Wu SH, Sankhagowit S, Biswas R, Wu S, Povinelli ML, Malmstadt N. Viscoelastic deformation of lipid bilayer vesicles. Soft Matter. 2015 Oct 07; 11(37):7385-91. PMID: 26268612; PMCID: PMC4573909.
    14. Hansen JS, Elbing K, Thompson JR, Malmstadt N, Lindkvist-Petersson K. Glucose transport machinery reconstituted in cell models. Chem Commun (Camb). 2015 Feb 11; 51(12):2316-9. PMID: 25562394; PMCID: PMC4308475.
    15. Runas KA, Malmstadt N. Low levels of lipid oxidation radically increase the passive permeability of lipid bilayers. Soft Matter. 2015 Jan 21; 11(3):499-505. PMID: 25415555; PMCID: PMC4477792.
    16. Hu PC, Malmstadt N. Asymmetric giant lipid vesicle fabrication. Methods Mol Biol. 2015; 1232:79-90. PMID: 25331129.
      View in: PubMed
    17. Bhargava KC, Thompson B, Malmstadt N. Discrete elements for 3D microfluidics. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15013-8. PMID: 25246553; PMCID: PMC4210303.
    18. Gutierrez MG, Malmstadt N. Human serotonin receptor 5-HT(1A) preferentially segregates to the liquid disordered phase in synthetic lipid bilayers. J Am Chem Soc. 2014 Oct 01; 136(39):13530-3. PMID: 25211019; PMCID: PMC4183657.
    19. Sankhagowit S, Wu SH, Biswas R, Riche CT, Povinelli ML, Malmstadt N. The dynamics of giant unilamellar vesicle oxidation probed by morphological transitions. Biochim Biophys Acta. 2014 Oct; 1838(10):2615-24. PMID: 24998358.
      View in: PubMed
    20. Riche CT, Zhang C, Gupta M, Malmstadt N. Fluoropolymer surface coatings to control droplets in microfluidic devices. Lab Chip. 2014 Jun 07; 14(11):1834-41. PMID: 24722827.
      View in: PubMed
    21. López Mora N, Hansen JS, Gao Y, Ronald AA, Kieltyka R, Malmstadt N, Kros A. Preparation of size tunable giant vesicles from cross-linked dextran(ethylene glycol) hydrogels. Chem Commun (Camb). 2014 Feb 25; 50(16):1953-5. PMID: 24407820; PMCID: PMC4114216.
    22. Hansen JS, Thompson JR, Hélix-Nielsen C, Malmstadt N. Lipid directed intrinsic membrane protein segregation. J Am Chem Soc. 2013 Nov 20; 135(46):17294-7. PMID: 24180248; PMCID: PMC3886709.
    23. Jang H, Hu PC, Jung S, Kim WY, Kim SM, Malmstadt N, Jeon TJ. Automated formation of multicomponent-encapuslating vesosomes using continuous flow microcentrifugation. Biotechnol J. 2013 Nov; 8(11):1341-6. PMID: 23894035; PMCID: PMC4084962.
    24. Solmaz ME, Sankhagowit S, Biswas R, Mejia CA, Povinelli ML, Malmstadt N. Optical stretching as a tool to investigate the mechanical properties of lipid bilayers. RSC Adv. 2013 Oct 07; 3(37). PMID: 24244843.
      View in: PubMed
    25. Dayani Y, Malmstadt N. Liposomes with double-stranded DNA anchoring the bilayer to a hydrogel core. Biomacromolecules. 2013 Oct 14; 14(10):3380-5. PMID: 24083513; PMCID: PMC3874235.
    26. Choubey A, Kalia RK, Malmstadt N, Nakano A, Vashishta P. Cholesterol translocation in a phospholipid membrane. Biophys J. 2013 Jun 04; 104(11):2429-36. PMID: 23746515; PMCID: PMC3672867.
    27. Lazarus LL, Riche CT, Malmstadt N, Brutchey RL. Effect of ionic liquid impurities on the synthesis of silver nanoparticles. Langmuir. 2012 Nov 13; 28(45):15987-93. PMID: 23092200.
      View in: PubMed
    28. Solmaz ME, Biswas R, Sankhagowit S, Thompson JR, Mejia CA, Malmstadt N, Povinelli ML. Optical stretching of giant unilamellar vesicles with an integrated dual-beam optical trap. Biomed Opt Express. 2012 Oct 01; 3(10):2419-27. PMID: 23082284; PMCID: PMC3469987.
    29. Dayani Y, Malmstadt N. Lipid bilayers covalently anchored to carbon nanotubes. Langmuir. 2012 May 29; 28(21):8174-82. PMID: 22568448; PMCID: PMC3378680.
    30. Lazarus LL, Riche CT, Marin BC, Gupta M, Malmstadt N, Brutchey RL. Two-phase microfluidic droplet flows of ionic liquids for the synthesis of gold and silver nanoparticles. ACS Appl Mater Interfaces. 2012 Jun 27; 4(6):3077-83. PMID: 22524284.
      View in: PubMed
    31. Riche CT, Marin BC, Malmstadt N, Gupta M. Vapor deposition of cross-linked fluoropolymer barrier coatings onto pre-assembled microfluidic devices. Lab Chip. 2011 Sep 21; 11(18):3049-52. PMID: 21850298.
      View in: PubMed
    32. Li S, Hu PC, Malmstadt N. Imaging molecular transport across lipid bilayers. Biophys J. 2011 Aug 03; 101(3):700-8. PMID: 21806938; PMCID: PMC3145269.
    33. Hu PC, Li S, Malmstadt N. Microfluidic fabrication of asymmetric giant lipid vesicles. ACS Appl Mater Interfaces. 2011 May; 3(5):1434-40. PMID: 21449588; PMCID: PMC3102129.
    34. Freeman LM, Li S, Dayani Y, Choi HS, Malmstadt N, Armani AM. Excitation of Cy5 in self-assembled lipid bilayers using optical microresonators. Appl Phys Lett. 2011 Apr 04; 98(14):143703. PMID: 21544215.
      View in: PubMed
    35. Lazarus LL, Yang AS, Chu S, Brutchey RL, Malmstadt N. Flow-focused synthesis of monodisperse gold nanoparticles using ionic liquids on a microfluidic platform. Lab Chip. 2010 Dec 21; 10(24):3377-9. PMID: 21057686.
      View in: PubMed
    36. Li S, Hu P, Malmstadt N. Confocal imaging to quantify passive transport across biomimetic lipid membranes. Anal Chem. 2010 Sep 15; 82(18):7766-71. PMID: 20722391; PMCID: PMC2939228.
    37. Yacobi NR, Malmstadt N, Fazlollahi F, DeMaio L, Marchelletta R, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles. Am J Respir Cell Mol Biol. 2010 May; 42(5):604-14. PMID: 19574531; PMCID: PMC2874446.
    38. Jeon TJ, Malmstadt N, Poulos JL, Schmidt JJ. Black lipid membranes stabilized through substrate conjugation to a hydrogel. Biointerphases. 2008 Jun; 3(2):FA96. PMID: 20408676.
      View in: PubMed
    39. Malmstadt N, Nash MA, Purnell RF, Schmidt JJ. Automated formation of lipid-bilayer membranes in a microfluidic device. Nano Lett. 2006 Sep; 6(9):1961-5. PMID: 16968008.
      View in: PubMed
    40. Jeon TJ, Malmstadt N, Schmidt JJ. Hydrogel-encapsulated lipid membranes. J Am Chem Soc. 2006 Jan 11; 128(1):42-3. PMID: 16390112.
      View in: PubMed
    41. Malmstadt N, Hoffman AS, Stayton PS. "Smart" mobile affinity matrix for microfluidic immunoassays. Lab Chip. 2004 Aug; 4(4):412-5. PMID: 15269814.
      View in: PubMed
    42. Malmstadt N, Yager P, Hoffman AS, Stayton PS. A smart microfluidic affinity chromatography matrix composed of poly(N-isopropylacrylamide)-coated beads. Anal Chem. 2003 Jul 01; 75(13):2943-9. PMID: 12964737.
      View in: PubMed
    43. Malmstadt N, Hyre DE, Ding Z, Hoffman AS, Stayton PS. Affinity thermoprecipitation and recovery of biotinylated biomolecules via a mutant streptavidin-smart polymer conjugate. Bioconjug Chem. 2003 May-Jun; 14(3):575-80. PMID: 12757381.
      View in: PubMed