Noah Malmstadt, PhD

Title(s)Professor
SchoolViterbi School of Engineering, Bme
AddressRTH 504
University Park Campus
Los Angeles CA 90089-1211
Phone+1 213 821 2034
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    Noah Malmstadt received a BS in Chemical Engineering from Caltech and a PhD in Bioengineering from the University of Washington. Following postdoctoral work at UCLA, he joined the Mork Family Department of Chemical Engineering and Materials Science at USC in 2007. His research focuses on synthetic cell membrane systems and multiphase microfluidic strategies for nanofabrication. He is the recipient of an Office of Naval Research Young Investigator award. His work in engineering education focuses on integrating team-based design projects into the core chemical engineering curriculum.

    Collapse Research 
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    A Target-Directed Reagent Pipeline via Microfluidic mRNA Display
    NIH R21CA204708May 23, 2017 - Apr 30, 2021
    Role: Principal Investigator
    Connecting plasma membrane function to lipid structure and organization with asym
    NIH R01GM093279Sep 30, 2010 - Jul 31, 2016
    Role: Principal Investigator
    Biomimetic Systems for Studying Nanoscale Structure Formation in Cell Membranes
    NIH R21AG033890May 1, 2009 - Apr 30, 2012
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Solvent Dependence of Ionic Liquid-Based Pt Nanoparticle Synthesis: Machine Learning-Aided In-Line Monitoring in a Flow Reactor. ACS Nano. 2024 Sep 17; 18(37):25542-25551. Pan B, Madani MS, Forsberg AP, Brutchey RL, Malmstadt N. PMID: 39235302; PMCID: PMC11411720.
      View in: PubMed   Mentions:    Fields:    
    2. Multivariate Bayesian Optimization of CoO Nanoparticles for CO2 Hydrogenation Catalysis. J Am Chem Soc. 2024 May 22; 146(20):14246-14259. Karadaghi LR, Williamson EM, To AT, Forsberg AP, Crans KD, Perkins CL, Hayden SC, LiBretto NJ, Baddour FG, Ruddy DA, Malmstadt N, Habas SE, Brutchey RL. PMID: 38728108; PMCID: PMC11117399.
      View in: PubMed   Mentions: 1     Fields:    
    3. 3D-printed microfluidic device for high-throughput production of lipid nanoparticles incorporating SARS-CoV-2 spike protein mRNA. Lab Chip. 2024 01 17; 24(2):162-170. Lin WS, Bostic WKV, Malmstadt N. PMID: 38165143; PMCID: PMC10853008.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. A Multistep, Multicomponent Extraction and Separation Microfluidic Route to Recycle Water-Miscible Ionic Liquid Solvents. Ind Eng Chem Res. 2024 Jan 10; 63(1):489-497. Pan B, Karadaghi LR, Brutchey RL, Malmstadt N. PMID: 38223501; PMCID: PMC10785803.
      View in: PubMed   Mentions: 1  
    5. Elucidating the Molecular Interactions between Lipids and Lysozyme: Evaporation Resistance and Bacterial Barriers for Dry Eye Disease. Nano Lett. 2023 10 25; 23(20):9451-9460. Lee D, Song S, Cho G, Dalle Ore LC, Malmstadt N, Fuwad A, Kim SM, Jeon TJ. PMID: 37842945.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Curvature preference of cubic CsPbBr3 quantum dots embedded onto phospholipid bilayer membranes. Soft Matter. 2023 May 31; 19(21):3966-3974. Chairil R, Malmstadt N. PMID: 37221902.
      View in: PubMed   Mentions:    Fields:    
    7. Oxidation of Membrane Lipids Alters the Activity of the Human Serotonin 1A Receptor. Langmuir. 2022 06 07; 38(22):6798-6807. Elbaradei A, Wang Z, Malmstadt N. PMID: 35608952.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    8. In-situ transfer vat photopolymerization for transparent microfluidic device fabrication. Nat Commun. 2022 02 17; 13(1):918. Xu Y, Qi F, Mao H, Li S, Zhu Y, Gong J, Wang L, Malmstadt N, Chen Y. PMID: 35177598; PMCID: PMC8854570.
      View in: PubMed   Mentions: 20     Fields:    
    9. Compatibility of Popular Three-Dimensional Printed Microfluidics Materials with In Vitro Enzymatic Reactions. ACS Appl Bio Mater. 2022 02 21; 5(2):818-824. Lin WS, Evenson WE, Bostic WKV, Roberts RW, Malmstadt N. PMID: 35138792; PMCID: PMC10371121.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    10. Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors (GPCRs). J Vis Exp. 2022 02 05; (180). Elbaradei A, Dalle Ore LC, Malmstadt N. PMID: 35188112.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Light-Triggered Unique Shape Transformation of Giant Polymersomes with Tubular Protrusions. Macromol Rapid Commun. 2021 Nov; 42(22):e2100474. Ren K, Blosser MC, Malmstadt N. PMID: 34553805.
      View in: PubMed   Mentions: 1     Fields:    
    12. An integrated microfluidic platform to fabricate single-micrometer asymmetric giant unilamellar vesicles (GUVs) using dielectrophoretic separation of microemulsions. Biomicrofluidics. 2021 Mar; 15(2):024112. Maktabi S, Malmstadt N, Schertzer JW, Chiarot PR. PMID: 33912267; PMCID: PMC8064763.
      View in: PubMed   Mentions: 1  
    13. Characterization of binding kinetics of A2AR to Gαs protein by surface plasmon resonance. Biophys J. 2021 05 04; 120(9):1641-1649. Koretz KS, McGraw CE, Stradley S, Elbaradei A, Malmstadt N, Robinson AS. PMID: 33675761; PMCID: PMC8204205.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    14. Carbon dioxide transport across membranes. Interface Focus. 2021 Apr 06; 11(2):20200090. Michenkova M, Taki S, Blosser MC, Hwang HJ, Kowatz T, Moss FJ, Occhipinti R, Qin X, Sen S, Shinn E, Wang D, Zeise BS, Zhao P, Malmstadt N, Vahedi-Faridi A, Tajkhorshid E, Boron WF. PMID: 33633837; PMCID: PMC7898146.
      View in: PubMed   Mentions: 16  
    15. Enabling Flow-Based Kinetic Off-Rate Selections Using a Microfluidic Enrichment Device. Anal Chem. 2020 08 04; 92(15):10218-10222. Evenson WE, Lin WS, Pang K, Czaja AT, Jalali-Yazdi F, Takahashi TT, Malmstadt N, Roberts RW. PMID: 32633489; PMCID: PMC10368462.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    16. Self-optimizing parallel millifluidic reactor for scaling nanoparticle synthesis. Chem Commun (Camb). 2020 Apr 04; 56(26):3745-3748. Wang L, Karadaghi LR, Brutchey RL, Malmstadt N. PMID: 32125333.
      View in: PubMed   Mentions: 8     Fields:    
    17. An Exceptionally Mild and Scalable Solution-Phase Synthesis of Molybdenum Carbide Nanoparticles for Thermocatalytic CO2 Hydrogenation. J Am Chem Soc. 2020 01 15; 142(2):1010-1019. Baddour FG, Roberts EJ, To AT, Wang L, Habas SE, Ruddy DA, Bedford NM, Wright J, Nash CP, Schaidle JA, Brutchey RL, Malmstadt N. PMID: 31894975.
      View in: PubMed   Mentions: 7     Fields:    
    18. Spectrophotometry in modular microfluidic architectures. Biomicrofluidics. 2019 Nov; 13(6):064121. Thompson B, Bhargava KC, Czaja AT, Pan B, Samuelsen BT, Malmstadt N. PMID: 31832119; PMCID: PMC6892708.
      View in: PubMed   Mentions: 2  
    19. Continuous Flow Methods of Fabricating Catalytically Active Metal Nanoparticles. ACS Appl Mater Interfaces. 2019 Aug 07; 11(31):27479-27502. Roberts EJ, Karadaghi LR, Wang L, Malmstadt N, Brutchey RL. PMID: 31287651.
      View in: PubMed   Mentions: 7     Fields:    
    20. Liposome production and concurrent loading of drug simulants by microfluidic hydrodynamic focusing. Eur Biophys J. 2019 Sep; 48(6):549-558. Lin WS, Malmstadt N. PMID: 31327019.
      View in: PubMed   Mentions: 6     Fields:    
    21. The lipid phase preference of the adenosine A2A receptor depends on its ligand binding state. Chem Commun (Camb). 2019 May 14; 55(40):5724-5727. Gutierrez MG, Deyell J, White KL, Dalle Ore LC, Cherezov V, Stevens RC, Malmstadt N. PMID: 31038495; PMCID: PMC6561478.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    22. Modular microfluidics for double emulsion formation. Methods Cell Biol. 2018; 148:161-176. Thompson B, Movsesian N, Cheng C, Karandikar P, Gupta M, Malmstadt N. PMID: 30473068.
      View in: PubMed   Mentions: 2     Fields:    
    23. Giant Lipid Vesicle Formation Using Vapor-Deposited Charged Porous Polymers. Langmuir. 2018 07 31; 34(30):9025-9035. Movsesian N, Tittensor M, Dianat G, Gupta M, Malmstadt N. PMID: 29961336.
      View in: PubMed   Mentions: 2     Fields:    
    24. Photolithographic patterned surface forms size-controlled lipid vesicles. APL Bioeng. 2018 Mar; 2(1):016104. Gertrude Gutierrez M, Yoshida S, Malmstadt N, Takeuchi S. PMID: 31069289; PMCID: PMC6481701.
      View in: PubMed   Mentions: 1  
    25. Evaluation of dextran(ethylene glycol) hydrogel films for giant unilamellar lipid vesicle production and their application for the encapsulation of polymersomes. Soft Matter. 2017 Aug 23; 13(33):5580-5588. Mora NL, Gao Y, Gutierrez MG, Peruzzi J, Bakker I, Peters RJRW, Siewert B, Bonnet S, Kieltyka RE, van Hest JCM, Malmstadt N, Kros A. PMID: 28730206; PMCID: PMC5586486.
      View in: PubMed   Mentions: 5     Fields:    
    26. Dynamics of Hydrogel-Assisted Giant Unilamellar Vesicle Formation from Unsaturated Lipid Systems. Langmuir. 2016 12 06; 32(48):12702-12709. Peruzzi J, Gutierrez MG, Mansfield K, Malmstadt N. PMID: 27934517.
      View in: PubMed   Mentions: 6     Fields:    
    27. G Protein-Coupled Receptors Incorporated into Rehydrated Diblock Copolymer Vesicles Retain Functionality. Small. 2016 Oct; 12(38):5256-5260. Gutierrez MG, Jalali-Yazdi F, Peruzzi J, Riche CT, Roberts RW, Malmstadt N. PMID: 27529518; PMCID: PMC5148614.
      View in: PubMed   Mentions: 3     Fields:    
    28. The Functional Activity of the Human Serotonin 5-HT1A Receptor Is Controlled by Lipid Bilayer Composition. Biophys J. 2016 06 07; 110(11):2486-2495. Gutierrez MG, Mansfield KS, Malmstadt N. PMID: 27276266; PMCID: PMC4922583.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    29. Oxidation of Membrane Curvature-Regulating Phosphatidylethanolamine Lipid Results in Formation of Bilayer and Cubic Structures. Langmuir. 2016 Mar 15; 32(10):2450-7. Sankhagowit S, Lee EY, Wong GC, Malmstadt N. PMID: 26866900; PMCID: PMC6559366.
      View in: PubMed   Mentions: 9     Fields:    
    30. Flow invariant droplet formation for stable parallel microreactors. Nat Commun. 2016 Feb 23; 7:10780. Riche CT, Roberts EJ, Gupta M, Brutchey RL, Malmstadt N. PMID: 26902825; PMCID: PMC4766398.
      View in: PubMed   Mentions: 16     Fields:    
    31. Temperature Sensing in Modular Microfluidic Architectures. Micromachines (Basel). 2016 Jan 18; 7(1). Bhargava KC, Thompson B, Tembhekar A, Malmstadt N. PMID: 30407384; PMCID: PMC6190081.
      View in: PubMed   Mentions: 4  
    32. Addition of Cleaved Tail Fragments during Lipid Oxidation Stabilizes Membrane Permeability Behavior. Langmuir. 2016 Jan 26; 32(3):779-86. Runas KA, Acharya SJ, Schmidt JJ, Malmstadt N. PMID: 26704691.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    33. Predicting the behavior of microfluidic circuits made from discrete elements. Sci Rep. 2015 Oct 30; 5:15609. Bhargava KC, Thompson B, Iqbal D, Malmstadt N. PMID: 26516059; PMCID: PMC4626777.
      View in: PubMed   Mentions: 7     Fields:    
    34. Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption. J Biol Chem. 2015 Oct 23; 290(43):25782-93. Kegulian NC, Sankhagowit S, Apostolidou M, Jayasinghe SA, Malmstadt N, Butler PC, Langen R. PMID: 26283787; PMCID: PMC4646232.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    35. Viscoelastic deformation of lipid bilayer vesicles. Soft Matter. 2015 Oct 07; 11(37):7385-91. Wu SH, Sankhagowit S, Biswas R, Wu S, Povinelli ML, Malmstadt N. PMID: 26268612; PMCID: PMC4573909.
      View in: PubMed   Mentions: 13     Fields:    
    36. Glucose transport machinery reconstituted in cell models. Chem Commun (Camb). 2015 Feb 11; 51(12):2316-9. Hansen JS, Elbing K, Thompson JR, Malmstadt N, Lindkvist-Petersson K. PMID: 25562394; PMCID: PMC4308475.
      View in: PubMed   Mentions: 9     Fields:    
    37. Low levels of lipid oxidation radically increase the passive permeability of lipid bilayers. Soft Matter. 2015 Jan 21; 11(3):499-505. Runas KA, Malmstadt N. PMID: 25415555; PMCID: PMC4477792.
      View in: PubMed   Mentions: 44     Fields:    Translation:Cells
    38. Asymmetric giant lipid vesicle fabrication. Methods Mol Biol. 2015; 1232:79-90. Hu PC, Malmstadt N. PMID: 25331129.
      View in: PubMed   Mentions: 1     Fields:    
    39. Discrete elements for 3D microfluidics. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15013-8. Bhargava KC, Thompson B, Malmstadt N. PMID: 25246553; PMCID: PMC4210303.
      View in: PubMed   Mentions: 90     Fields:    
    40. Human serotonin receptor 5-HT(1A) preferentially segregates to the liquid disordered phase in synthetic lipid bilayers. J Am Chem Soc. 2014 Oct 01; 136(39):13530-3. Gutierrez MG, Malmstadt N. PMID: 25211019; PMCID: PMC4183657.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    41. The dynamics of giant unilamellar vesicle oxidation probed by morphological transitions. Biochim Biophys Acta. 2014 Oct; 1838(10):2615-24. Sankhagowit S, Wu SH, Biswas R, Riche CT, Povinelli ML, Malmstadt N. PMID: 24998358.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    42. Fluoropolymer surface coatings to control droplets in microfluidic devices. Lab Chip. 2014 Jun 07; 14(11):1834-41. Riche CT, Zhang C, Gupta M, Malmstadt N. PMID: 24722827.
      View in: PubMed   Mentions: 9     Fields:    
    43. Preparation of size tunable giant vesicles from cross-linked dextran(ethylene glycol) hydrogels. Chem Commun (Camb). 2014 Feb 25; 50(16):1953-5. López Mora N, Hansen JS, Gao Y, Ronald AA, Kieltyka R, Malmstadt N, Kros A. PMID: 24407820; PMCID: PMC4114216.
      View in: PubMed   Mentions: 17     Fields:    
    44. Lipid directed intrinsic membrane protein segregation. J Am Chem Soc. 2013 Nov 20; 135(46):17294-7. Hansen JS, Thompson JR, Hélix-Nielsen C, Malmstadt N. PMID: 24180248; PMCID: PMC3886709.
      View in: PubMed   Mentions: 22     Fields:    
    45. Automated formation of multicomponent-encapuslating vesosomes using continuous flow microcentrifugation. Biotechnol J. 2013 Nov; 8(11):1341-6. Jang H, Hu PC, Jung S, Kim WY, Kim SM, Malmstadt N, Jeon TJ. PMID: 23894035; PMCID: PMC4084962.
      View in: PubMed   Mentions: 4     Fields:    
    46. Optical stretching as a tool to investigate the mechanical properties of lipid bilayers. RSC Adv. 2013 Oct 07; 3(37). Solmaz ME, Sankhagowit S, Biswas R, Mejia CA, Povinelli ML, Malmstadt N. PMID: 24244843; PMCID: PMC3827026.
      View in: PubMed   Mentions: 7  
    47. Liposomes with double-stranded DNA anchoring the bilayer to a hydrogel core. Biomacromolecules. 2013 Oct 14; 14(10):3380-5. Dayani Y, Malmstadt N. PMID: 24083513; PMCID: PMC3874235.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    48. Cholesterol translocation in a phospholipid membrane. Biophys J. 2013 Jun 04; 104(11):2429-36. Choubey A, Kalia RK, Malmstadt N, Nakano A, Vashishta P. PMID: 23746515; PMCID: PMC3672867.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    49. Effect of ionic liquid impurities on the synthesis of silver nanoparticles. Langmuir. 2012 Nov 13; 28(45):15987-93. Lazarus LL, Riche CT, Malmstadt N, Brutchey RL. PMID: 23092200.
      View in: PubMed   Mentions: 9     Fields:    
    50. Optical stretching of giant unilamellar vesicles with an integrated dual-beam optical trap. Biomed Opt Express. 2012 Oct 01; 3(10):2419-27. Solmaz ME, Biswas R, Sankhagowit S, Thompson JR, Mejia CA, Malmstadt N, Povinelli ML. PMID: 23082284; PMCID: PMC3469987.
      View in: PubMed   Mentions: 15  
    51. Lipid bilayers covalently anchored to carbon nanotubes. Langmuir. 2012 May 29; 28(21):8174-82. Dayani Y, Malmstadt N. PMID: 22568448; PMCID: PMC3378680.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    52. Two-phase microfluidic droplet flows of ionic liquids for the synthesis of gold and silver nanoparticles. ACS Appl Mater Interfaces. 2012 Jun 27; 4(6):3077-83. Lazarus LL, Riche CT, Marin BC, Gupta M, Malmstadt N, Brutchey RL. PMID: 22524284.
      View in: PubMed   Mentions: 12     Fields:    
    53. Vapor deposition of cross-linked fluoropolymer barrier coatings onto pre-assembled microfluidic devices. Lab Chip. 2011 Sep 21; 11(18):3049-52. Riche CT, Marin BC, Malmstadt N, Gupta M. PMID: 21850298.
      View in: PubMed   Mentions: 2     Fields:    
    54. Imaging molecular transport across lipid bilayers. Biophys J. 2011 Aug 03; 101(3):700-8. Li S, Hu PC, Malmstadt N. PMID: 21806938; PMCID: PMC3145269.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    55. Microfluidic fabrication of asymmetric giant lipid vesicles. ACS Appl Mater Interfaces. 2011 May; 3(5):1434-40. Hu PC, Li S, Malmstadt N. PMID: 21449588; PMCID: PMC3102129.
      View in: PubMed   Mentions: 41     Fields:    
    56. Excitation of Cy5 in self-assembled lipid bilayers using optical microresonators. Appl Phys Lett. 2011 Apr 04; 98(14):143703. Freeman LM, Li S, Dayani Y, Choi HS, Malmstadt N, Armani AM. PMID: 21544215; PMCID: PMC3085537.
      View in: PubMed   Mentions: 6  
    57. Flow-focused synthesis of monodisperse gold nanoparticles using ionic liquids on a microfluidic platform. Lab Chip. 2010 Dec 21; 10(24):3377-9. Lazarus LL, Yang AS, Chu S, Brutchey RL, Malmstadt N. PMID: 21057686.
      View in: PubMed   Mentions: 7     Fields:    
    58. Confocal imaging to quantify passive transport across biomimetic lipid membranes. Anal Chem. 2010 Sep 15; 82(18):7766-71. Li S, Hu P, Malmstadt N. PMID: 20722391; PMCID: PMC2939228.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    59. Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles. Am J Respir Cell Mol Biol. 2010 May; 42(5):604-14. Yacobi NR, Malmstadt N, Fazlollahi F, DeMaio L, Marchelletta R, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. PMID: 19574531; PMCID: PMC2874446.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    60. Black lipid membranes stabilized through substrate conjugation to a hydrogel. Biointerphases. 2008 Jun; 3(2):FA96. Jeon TJ, Malmstadt N, Poulos JL, Schmidt JJ. PMID: 20408676.
      View in: PubMed   Mentions: 5     Fields:    
    61. Automated formation of lipid-bilayer membranes in a microfluidic device. Nano Lett. 2006 Sep; 6(9):1961-5. Malmstadt N, Nash MA, Purnell RF, Schmidt JJ. PMID: 16968008.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    62. Hydrogel-encapsulated lipid membranes. J Am Chem Soc. 2006 Jan 11; 128(1):42-3. Jeon TJ, Malmstadt N, Schmidt JJ. PMID: 16390112.
      View in: PubMed   Mentions: 21     Fields:    
    63. "Smart" mobile affinity matrix for microfluidic immunoassays. Lab Chip. 2004 Aug; 4(4):412-5. Malmstadt N, Hoffman AS, Stayton PS. PMID: 15269814.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    64. A smart microfluidic affinity chromatography matrix composed of poly(N-isopropylacrylamide)-coated beads. Anal Chem. 2003 Jul 01; 75(13):2943-9. Malmstadt N, Yager P, Hoffman AS, Stayton PS. PMID: 12964737.
      View in: PubMed   Mentions: 15     Fields:    
    65. Affinity thermoprecipitation and recovery of biotinylated biomolecules via a mutant streptavidin-smart polymer conjugate. Bioconjug Chem. 2003 May-Jun; 14(3):575-80. Malmstadt N, Hyre DE, Ding Z, Hoffman AS, Stayton PS. PMID: 12757381.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
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