Douglas E. Feldman, PhD

Title(s)Assistant Professor of Research Pathology
SchoolKeck School of Medicine of Usc
AddressHMR 2011 Zonal Ave
Health Sciences Campus
Los Angeles CA 90089-9092
Phone+1 323 442 3121
ORCID ORCID Icon0000-0003-0659-0788 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Harvard College, Cambridge, MA. A.B. Magna cum laude Biochemistry
    Stanford University, Stanford, CA.Ph.DMolecular Cell Biology

    Collapse Overview 
    Collapse Overview
    Dr. Feldman's research team studies the following major topic areas:

    1. Immunomodulation and immune engineering for the treatment of inflammation and fibrosis.
    2. Roles of modified DNA bases in immune signaling and gene control.
    2. Functional analysis of viral counter-immune systems.


    Categories: Gene Control, Stem Cells, Cancer, Epigenetics, DNA modification, immune engineering, immunotherapy, fibrosis, AALD

    Collapse Research 
    Collapse Research Activities and Funding
    Activation of NK cell-mediated protective immunity for the systemic treatment of ALD
    NIH 1R21AA029741-01A1Sep 1, 2023 - Aug 31, 2025
    Role: PI
    STING-Activating CAR-NK Cell Therapy
    US DOD CDMRP RA210134: Award W81XWH-22-1-0897Aug 15, 2022 - Feb 14, 2024
    Role: PI
    Description: Design, engineer and test STING-activating CAR-NK cell therapy
    Engineering CAR-T for treatment of alcoholic liver disease
    NIH R21AA027535Sep 20, 2019 - Aug 31, 2021
    Role: PI
    Robert E. and May R. Wright Foundation Trust
    American Cancer Society
    James H. Zumberge Faculty Research and Innovation Fund

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells. J Clin Invest. 2024 Oct 01; 134(19). Chen CL, Tsukamoto H, Liu JC, Kashiwabara C, Feldman D, Sher L, Dooley S, French SW, Mishra L, Petrovic L, Jeong JH, Machida K. PMID: 39352392; PMCID: PMC11444152.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. MSI2 promotes translation of multiple IRES-containing oncogenes and virus to induce self-renewal of tumor initiating stem-like cells. Cell Death Discov. 2023 Apr 28; 9(1):141. Yeh DW, Zhao X, Siddique HR, Zheng M, Choi HY, Machida T, Narayanan P, Kou Y, Punj V, Tahara SM, Feldman DE, Chen L, Machida K. PMID: 37117191; PMCID: PMC10147607.
      View in: PubMed   Mentions: 4  
    3. Bacteriophage antidefense genes that neutralize TIR and STING immune responses. Cell Rep. 2023 04 25; 42(4):112305. Ho P, Chen Y, Biswas S, Canfield E, Abdolvahabi A, Feldman DE. PMID: 36952342.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    4. Bacteriophage anti-defense genes that neutralize TIR and STING immune responses. bioRxiv. 2022. Peiyin Ho, Yibu Chen, Subarna Biswas, Ethan Canfield, Douglas E. Feldman. . View Publication.
    5. HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells. Mol Cell. 2020 01 16; 77(2):384-394.e4. Shukla V, Halabelian L, Balagere S, Samaniego-Castruita D, Feldman DE, Arrowsmith CH, Rao A, Aravind L. PMID: 31806351; PMCID: PMC6980713.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    6. An Adversarial DNA N6-Methyladenine-Sensor Network Preserves Polycomb Silencing. Mol Cell. 2019 06 20; 74(6):1138-1147.e6. Kweon SM, Chen Y, Moon E, Kvederaviciute K, Klimasauskas S, Feldman DE. PMID: 30982744; PMCID: PMC6591016.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    7. Erasure of Tet-Oxidized 5-Methylcytosine by a SRAP Nuclease. Cell Rep. 2017 Oct 10; 21(2):482-494. Kweon SM, Zhu B, Chen Y, Aravind L, Xu SY, Feldman DE. PMID: 29020633.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    8. Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells. J Clin Invest. 2013 Jul; 123(7):2832-49. Chen CL, Tsukamoto H, Liu JC, Kashiwabara C, Feldman D, Sher L, Dooley S, French SW, Mishra L, Petrovic L, Jeong JH, Machida K. PMID: 23921128; PMCID: PMC3696549.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    9. The TBC1D15 oncoprotein controls stem cell self-renewal through destabilization of the Numb-p53 complex. PLoS One. 2013; 8(2):e57312. Feldman DE, Chen C, Punj V, Machida K. PMID: 23468968; PMCID: PMC3584131.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    10. Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:19-22. Machida K, Chen CL, Liu JC, Kashiwabara C, Feldman D, French SW, Sher L, Hyeongnam JJ, Tsukamoto H. PMID: 22320911; PMCID: PMC3306127.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    11. Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):829-34. Feldman DE, Chen C, Punj V, Tsukamoto H, Machida K. PMID: 22207628; PMCID: PMC3271911.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    12. Hypoxia and the unfolded protein response. Methods Enzymol. 2007; 435:275-93. Koumenis C, Bi M, Ye J, Feldman D, Koong AC. PMID: 17998059.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    13. Identification of mitogen-activated protein kinase signaling pathways that confer resistance to endoplasmic reticulum stress in Saccharomyces cerevisiae. Mol Cancer Res. 2005 Dec; 3(12):669-77. Chen Y, Feldman DE, Deng C, Brown JA, De Giacomo AF, Gaw AF, Shi G, Le QT, Brown JM, Koong AC. PMID: 16380504.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    14. The unfolded protein response: a novel component of the hypoxic stress response in tumors. Mol Cancer Res. 2005 Nov; 3(11):597-605. Feldman DE, Chauhan V, Koong AC. PMID: 16317085.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansCells
    15. Tumorigenic mutations in VHL disrupt folding in vivo by interfering with chaperonin binding. Mol Cell. 2003 Nov; 12(5):1213-24. Feldman DE, Spiess C, Howard DE, Frydman J. PMID: 14636579.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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