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Douglas E. Feldman, PhD

Title(s)Assistant Professor of Research Pathology
Phone+1 323 442 3121
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    Collapse Biography 
    Collapse Education and Training
    Harvard College, Cambridge, MA. A.B. Magna cum laude Biochemistry
    Stanford University, Stanford, CA.Ph.DMolecular Cell Biology

    Collapse Overview 
    Collapse Overview
    Our laboratory studies how conserved elements of bacterial anti-phage immunity and phage counter-restriction systems function in the context of human innate immunity and in gene control.


    Categories: Gene Control, Stem Cells, Cancer, Epigenetics, DNA modification

    Collapse Research 
    Collapse Research Activities and Funding
    Engineering CAR-T for treatment of alcoholic liver disease
    NIH/NIAAA R21AA027535Sep 20, 2019 - Aug 31, 2021
    Role: Principal Investigator
    James H. Zumberge Faculty Research and Innovation Fund
    Robert E. and May R. Wright Foundation Trust
    American Cancer Society

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Shukla V, Halabelian L, Balagere S, Samaniego-Castruita D, Feldman DE, Arrowsmith CH, Rao A, Aravind L. HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells. Mol Cell. 2020 Mar 05; 77(5):1154. PMID: 32142687.
      View in: PubMed
    2. Shukla V, Halabelian L, Balagere S, Samaniego-Castruita D, Feldman DE, Arrowsmith CH, Rao A, Aravind L. HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells. Mol Cell. 2020 Jan 16; 77(2):384-394.e4. PMID: 31806351.
      View in: PubMed
    3. Kweon SM, Chen Y, Moon E, Kvederaviciute K, Klimasauskas S, Feldman DE. An Adversarial DNA N6-Methyladenine-Sensor Network Preserves Polycomb Silencing. Mol Cell. 2019 06 20; 74(6):1138-1147.e6. PMID: 30982744.
      View in: PubMed
    4. Kweon SM, Zhu B, Chen Y, Aravind L, Xu SY, Feldman DE. Erasure of Tet-Oxidized 5-Methylcytosine by a SRAP Nuclease. Cell Rep. 2017 Oct 10; 21(2):482-494. PMID: 29020633.
      View in: PubMed
    5. Chen CL, Tsukamoto H, Liu JC, Kashiwabara C, Feldman D, Sher L, Dooley S, French SW, Mishra L, Petrovic L, Jeong JH, Machida K. Reciprocal regulation by TLR4 and TGF-ß in tumor-initiating stem-like cells. J Clin Invest. 2013 Jul; 123(7):2832-49. PMID: 23921128.
      View in: PubMed
    6. Feldman DE, Chen C, Punj V, Machida K. The TBC1D15 oncoprotein controls stem cell self-renewal through destabilization of the Numb-p53 complex. PLoS One. 2013; 8(2):e57312. PMID: 23468968.
      View in: PubMed
    7. Machida K, Chen CL, Liu JC, Kashiwabara C, Feldman D, French SW, Sher L, Hyeongnam JJ, Tsukamoto H. Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:19-22. PMID: 22320911.
      View in: PubMed
    8. Feldman DE, Chen C, Punj V, Tsukamoto H, Machida K. Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):829-34. PMID: 22207628.
      View in: PubMed
    9. Feldman DE, Spiess C, Howard DE, Frydman J. Tumorigenic mutations in VHL disrupt folding in vivo by interfering with chaperonin binding. Mol Cell. 2003 Nov; 12(5):1213-24. PMID: 14636579.
      View in: PubMed