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Axel Schonthal, PhD

Title(s)Associate Professor of Molecular Microbiology & Immunology
AddressHMR 405A 2011 Zonal Avenue
Health Sciences Campus
Los Angeles CA 90089
Phone+1 323 442 1730
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    Other Positions
    Title(s)Associate Dean for Biomedical Master's Programs


    Collapse Biography 
    Collapse Education and Training
    University of Karlsruhe, GermanyPhDMolecular Biology
    UC San Diego, San Diego, CAPostdocCancer Biology

    Collapse Overview 
    Collapse Overview
    The Schonthal lab performs preclinical cancer research and pursues anticancer drug development. The main focus is on brain malignancies, which include primary brain cancers (such as glioblastoma) and secondary brain cancers (such as melanoma or breast cancer that has spread to the brain). The work is done in collaboration with Dr. Thomas Chen, Director of the USC Brain Tumor Group, and Dr. Florence Hofman from the Department of Pathology. This joint approach supports interdisciplinary efforts that translate laboratory findings to patient applications.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A perillyl alcohol-conjugated analog of 3-bromopyruvate without cellular uptake dependency on monocarboxylate transporter 1 and with activity in 3-BP-resistant tumor cells. Cancer Lett. 2017 08 01; 400:161-174. Chen TC, Yu J, Nouri Nigjeh E, Wang W, Myint PT, Zandi E, Hofman FM, Schönthal AH. PMID: 28450161.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    2. Perillyl Alcohol and Its Drug-Conjugated Derivatives as Potential Novel Methods of Treating Brain Metastases. Int J Mol Sci. 2016 Sep 02; 17(9). Chen TC, Da Fonseca CO, Schönthal AH. PMID: 27598140.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    3. Chemotherapeutic effect of a novel temozolomide analog on nasopharyngeal carcinoma in vitro and in vivo. J Biomed Sci. 2015 Aug 19; 22:71. Chen TC, Cho HY, Wang W, Wetzel SJ, Singh A, Nguyen J, Hofman FM, Schönthal AH. PMID: 26282951.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    4. Preclinical development and clinical use of perillyl alcohol for chemoprevention and cancer therapy. Am J Cancer Res. 2015; 5(5):1580-93. Chen TC, Fonseca CO, Schönthal AH. PMID: 26175929.
      View in: PubMed   Mentions:
    5. A novel temozolomide analog, NEO212, with enhanced activity against MGMT-positive melanoma in vitro and in vivo. Cancer Lett. 2015 Mar 28; 358(2):144-151. Chen TC, Cho HY, Wang W, Nguyen J, Jhaveri N, Rosenstein-Sisson R, Hofman FM, Schönthal AH. PMID: 25524552.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    6. A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo. Mol Cancer Ther. 2014 May; 13(5):1181-93. Chen TC, Cho HY, Wang W, Barath M, Sharma N, Hofman FM, Schönthal AH. PMID: 24623736.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    7. Pharmacological targeting of endoplasmic reticulum stress signaling in cancer. Biochem Pharmacol. 2013 Mar 01; 85(5):653-666. Schönthal AH. PMID: 23000916.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    8. Adverse effects of concentrated green tea extracts. Mol Nutr Food Res. 2011 Jun; 55(6):874-85. Schönthal AH. PMID: 21538851.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
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