 Axel Schonthal, PhD
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| Title | Associate Professor of Molecular Microbiology & Immunology |
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| Institution | University of Southern California |
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| Department | Molecular Microbiology and Immunology |
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| Address | HMR 405A 2011 Zonal Avenue
Health Sciences Campus
Los Angeles CA 90089
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| Phone | +1 323 442 1730 |
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| vCard | Download vCard |
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 Biography | University of Karlsruhe, Germany | PhD | | Molecular Biology | | UC San Diego, San Diego, CA | Postdoc | | Cancer Biology |
Overview The Schonthal lab performs preclinical cancer research and pursues anticancer drug development. The main focus is on brain malignancies, which include primary brain cancers (such as glioblastoma) and secondary brain cancers (such as melanoma or breast cancer that has spread to the brain). The work is done in collaboration with Dr. Thomas Chen, Director of the USC Brain Tumor Group, and Dr. Florence Hofman from the Department of Pathology. This joint approach supports interdisciplinary efforts that translate laboratory findings to patient applications.
Bibliographic
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Chen TC, Yu J, Nouri Nigjeh E, Wang W, Myint PT, Zandi E, Hofman FM, Schönthal AH. A perillyl alcohol-conjugated analog of 3-bromopyruvate without cellular uptake dependency on monocarboxylate transporter 1 and with activity in 3-BP-resistant tumor cells. Cancer Lett. 2017 08 01; 400:161-174. PMID: 28450161.
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Chen TC, Da Fonseca CO, Schönthal AH. Perillyl Alcohol and Its Drug-Conjugated Derivatives as Potential Novel Methods of Treating Brain Metastases. Int J Mol Sci. 2016 Sep 02; 17(9). PMID: 27598140.
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Chen TC, Cho HY, Wang W, Wetzel SJ, Singh A, Nguyen J, Hofman FM, Schönthal AH. Chemotherapeutic effect of a novel temozolomide analog on nasopharyngeal carcinoma in vitro and in vivo. J Biomed Sci. 2015 Aug 19; 22:71. PMID: 26282951; PMCID: PMC4539921.
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Chen TC, Fonseca CO, Schönthal AH. Preclinical development and clinical use of perillyl alcohol for chemoprevention and cancer therapy. Am J Cancer Res. 2015; 5(5):1580-93. PMID: 26175929; PMCID: PMC4497427.
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Chen TC, Cho HY, Wang W, Nguyen J, Jhaveri N, Rosenstein-Sisson R, Hofman FM, Schönthal AH. A novel temozolomide analog, NEO212, with enhanced activity against MGMT-positive melanoma in vitro and in vivo. Cancer Lett. 2015 Mar 28; 358(2):144-151. PMID: 25524552.
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Chen TC, Cho HY, Wang W, Barath M, Sharma N, Hofman FM, Schönthal AH. A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo. Mol Cancer Ther. 2014 May; 13(5):1181-93. PMID: 24623736.
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Schönthal AH. Pharmacological targeting of endoplasmic reticulum stress signaling in cancer. Biochem Pharmacol. 2013 Mar 01; 85(5):653-66. PMID: 23000916.
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Schönthal AH. Adverse effects of concentrated green tea extracts. Mol Nutr Food Res. 2011 Jun; 55(6):874-85. PMID: 21538851.
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