Axel Schonthal, PhD

Title(s)Associate Professor of Molecular Microbiology & Immunology
SchoolKeck School of Medicine of Usc
AddressHMR 405A 2011 Zonal Avenue
Health Sciences Campus
Los Angeles CA 90089
Phone+1 323 442 1730
ORCID ORCID Icon0000-0003-0662-5653 Additional info
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    Other Positions
    Title(s)Associate Dean for Biomedical Master's Programs


    Collapse Biography 
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    University of Karlsruhe, GermanyPhDMolecular Biology
    UC San Diego, San Diego, CAPostdocCancer Biology

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    The Schönthal lab performs preclinical cancer research and pursues anticancer drug development. The main focus is on brain malignancies, which include primary brain cancers (such as glioblastoma) and secondary brain cancers (such as melanoma or breast cancer that has spread to the brain). The work is done in collaboration with Dr. Thomas Chen, a neurosurgeon and Director of the USC Brain Tumor Group. This joint approach supports interdisciplinary efforts that translate laboratory findings to patient applications.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. NEO212, a Perillyl Alcohol-Temozolomide Conjugate, Triggers Macrophage Differentiation of Acute Myeloid Leukemia Cells and Blocks Their Tumorigenicity. Cancers (Basel). 2022 Dec 09; 14(24). Chen TC, Minea RO, Swenson S, Yang Z, Thein TZ, Sch?nthal AH. PMID: 36551551; PMCID: PMC9776529.
      View in: PubMed   Mentions:
    2. Detection of perillyl alcohol and its metabolite perillic acid in postsurgical glioblastoma tissue after intranasal administration of NEO100: illustrative case. J Neurosurg Case Lessons. 2022 Aug 22; 4(8). Sch?nthal AH, Swenson S, Bonney PA, Wagle N, Simmon VF, Mathew AJ, Hurth KM, Chen TC. PMID: 36088606; PMCID: PMC9706323.
      View in: PubMed   Mentions: 1  
    3. The Monoterpenoid Perillyl Alcohol: Anticancer Agent and Medium to Overcome Biological Barriers. Pharmaceutics. 2021 Dec 16; 13(12). Chen TC, da Fonseca CO, Levin D, Schönthal AH. PMID: 34959448; PMCID: PMC8709132.
      View in: PubMed   Mentions: 2  
    4. Enhanced brain delivery and therapeutic activity of trastuzumab after blood-brain barrier opening by NEO100 in mouse models of brain-metastatic breast cancer. Neuro Oncol. 2021 10 01; 23(10):1656-1667. Wang W, He H, Mar?n-Ramos NI, Zeng S, Swenson SD, Cho HY, Fu J, Beringer PM, Neman J, Chen L, Sch?nthal AH, Chen TC. PMID: 33659980; PMCID: PMC8485439.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    5. Potentially Curative Therapeutic Activity of NEO212, a Perillyl Alcohol-Temozolomide Conjugate, in Preclinical Cytarabine-Resistant Models of Acute Myeloid Leukemia. Cancers (Basel). 2021 Jul 06; 13(14). Sch?nthal AH, Swenson S, Minea RO, Kim HN, Cho H, Mohseni N, Kim YM, Chen TC. PMID: 34298603; PMCID: PMC8305595.
      View in: PubMed   Mentions: 2  
    6. Phase I trial of intranasal NEO100, highly purified perillyl alcohol, in adult patients with recurrent glioblastoma. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab005. Sch?nthal AH, Peereboom DM, Wagle N, Lai R, Mathew AJ, Hurth KM, Simmon VF, Howard SP, Taylor LP, Chow F, da Fonseca CO, Chen TC. PMID: 33604574; PMCID: PMC7879254.
      View in: PubMed   Mentions: 5  
    7. NEO100 enables brain delivery of blood?brain barrier impermeable therapeutics. Neuro Oncol. 2021 01 30; 23(1):63-75. Wang W, Mar?n-Ramos NI, He H, Zeng S, Cho HY, Swenson SD, Zheng L, Epstein AL, Sch?nthal AH, Hofman FM, Chen L, Chen TC. PMID: 32877532; PMCID: PMC7850137.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    8. Pharmacokinetic properties of the temozolomide perillyl alcohol conjugate (NEO212) in mice. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa160. Cho HY, Swenson S, Thein TZ, Wang W, Wijeratne NR, Mar?n-Ramos NI, Katz JE, Hofman FM, Sch?nthal AH, Chen TC. PMID: 33392507; PMCID: PMC7764505.
      View in: PubMed   Mentions: 3  
    9. Adjuvant effect of low-carbohydrate diet on outcomes of patients with recurrent glioblastoma under intranasal perillyl alcohol therapy. Surg Neurol Int. 2020; 11:389. Santos JG, Faria G, Cruz WDCSD, Fontes CA, Schönthal AH, Quirico-Santos T, da Fonseca CO. PMID: 33282452; PMCID: PMC7710475.
      View in: PubMed   Mentions: 1  
    10. Developing a clinically relevant radiosensitizer for temozolomide-resistant gliomas. PLoS One. 2020; 15(9):e0238238. Minea RO, Duc TC, Swenson SD, Cho HY, Huang M, Hartman H, Hofman FM, Sch?nthal AH, Chen TC. PMID: 32881880; PMCID: PMC7470340.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. Cytotoxic impact of a perillyl alcohol-temozolomide conjugate, NEO212, on cutaneous T-cell lymphoma in vitro. Ther Adv Med Oncol. 2019; 11:1758835919891567. Silva-Hirschberg C, Hartman H, Stack S, Swenson S, Minea RO, Davitz MA, Chen TC, Sch?nthal AH. PMID: 31839810; PMCID: PMC6900611.
      View in: PubMed   Mentions: 5  
    12. Efficient brain targeting and therapeutic intracranial activity of bortezomib through intranasal co-delivery with NEO100 in rodent glioblastoma models. J Neurosurg. 2019 Mar 15; 132(3):959-967. Wang W, Swenson S, Cho HY, Hofman FM, Sch?nthal AH, Chen TC. PMID: 30875688.
      View in: PubMed   Mentions: 6     Fields:    
    13. Rare Stochastic Expression of O6-Methylguanine- DNA Methyltransferase (MGMT) in MGMT-Negative Melanoma Cells Determines Immediate Emergence of Drug-Resistant Populations upon Treatment with Temozolomide In Vitro and In Vivo. Cancers (Basel). 2018 Sep 28; 10(10). Chen TC, Chan N, Minea RO, Hartman H, Hofman FM, Sch?nthal AH. PMID: 30274152; PMCID: PMC6209933.
      View in: PubMed   Mentions: 2  
    14. A perillyl alcohol-conjugated analog of 3-bromopyruvate without cellular uptake dependency on monocarboxylate transporter 1 and with activity in 3-BP-resistant tumor cells. Cancer Lett. 2017 08 01; 400:161-174. Chen TC, Yu J, Nouri Nigjeh E, Wang W, Myint PT, Zandi E, Hofman FM, Sch?nthal AH. PMID: 28450161.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
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