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Tin A Than, PhD, MD

Title(s)Assistant Professor of Research Medicine
Address2011 Zonal Avenue HMR 612 Mail Code:9091
Health Sciences Campus
Los Angeles CA 90089-9091
Phone+1 323 442 3175
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    Dr. Than's major areas of research interest include mitochondria biogensis, stress response and mitophagy in liver patho-physiology and developmental biology, and regulation of gene expression by reactive oxygen species and derivative DNA adducts in liver patho-physiology and developmental biology. His current research entails mitochondrial retrograde signaling and stress response, and mitochondrial biogenesis in liver diseases.

    Dr. Than earned his medical degree from University of Yangon, Institute of Medicine. He then went on to earn his PhD in Free Radical Biology & Molecular Biology from Okayama University Graduate School of Medicine and Dentistry.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Acetaminophen Hepatotoxicity: Strong Offense and Weakened Defense. Hepatology. 2020 May; 71(5):1530-1532. Kaplowitz N, Than TA, Win S. PMID: 32065403.
      View in: PubMed   Mentions:    Fields:    
    2. Gut Microbiota and Liver Injury (I)-Acute Liver Injury. Adv Exp Med Biol. 2020; 1238:23-37. Wu G, Win S, Than TA, Chen P, Kaplowitz N. PMID: 32323178.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury. J Clin Invest. 2019 12 02; 129(12):5278-5293. Win S, Min RW, Chen CQ, Zhang J, Chen Y, Li M, Suzuki A, Abdelmalek MF, Wang Y, Aghajan M, Aung FW, Diehl AM, Davis RJ, Than TA, Kaplowitz N. PMID: 31487267.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    4. Sex Differences in Nonalcoholic Fatty Liver Disease: State of the Art and Identification of Research Gaps. Hepatology. 2019 10; 70(4):1457-1469. Lonardo A, Nascimbeni F, Ballestri S, Fairweather D, Win S, Than TA, Abdelmalek MF, Suzuki A. PMID: 30924946.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    5. The Regulation of JNK Signaling Pathways in Cell Death through the Interplay with Mitochondrial SAB and Upstream Post-Translational Effects. Int J Mol Sci. 2018 Nov 20; 19(11). Win S, Than TA, Kaplowitz N. PMID: 30463289.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    6. New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases. Hepatology. 2018 05; 67(5):2013-2024. Win S, Than TA, Zhang J, Oo C, Min RWM, Kaplowitz N. PMID: 29194686.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    7. The role of MAP2 kinases and p38 kinase in acute murine liver injury models. Cell Death Dis. 2017 06 29; 8(6):e2903. Zhang J, Min RWM, Le K, Zhou S, Aghajan M, Than TA, Win S, Kaplowitz N. PMID: 28661486.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    8. Antcin H Protects Against Acute Liver Injury Through Disruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria. Antioxid Redox Signal. 2017 02 10; 26(5):207-220. Huo Y, Win S, Than TA, Yin S, Ye M, Hu H, Kaplowitz N. PMID: 27596680.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    9. c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src. Hepatology. 2016 06; 63(6):1987-2003. Win S, Than TA, Min RW, Aghajan M, Kaplowitz N. PMID: 26845758.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    10. Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity. J Hepatol. 2015 Jul; 63(1):5-7. Kaplowitz N, Win S, Than TA, Liu ZX, Dara L. PMID: 25770661.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    11. Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity. J Hepatol. 2015 Jun; 62(6):1367-74. Win S, Than TA, Le BH, García-Ruiz C, Fernandez-Checa JC, Kaplowitz N. PMID: 25666017.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    12. In vitro assays of mitochondrial function/dysfunction. Clin Pharmacol Ther. 2014 Dec; 96(6):665-8. Than TA, Win S, Kaplowitz N. PMID: 25207701.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    13. JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death. Cell Death Dis. 2014 Jan 09; 5:e989. Win S, Than TA, Fernandez-Checa JC, Kaplowitz N. PMID: 24407242.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    14. Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria. Trends Pharmacol Sci. 2013 Apr; 34(4):243-53. Han D, Dara L, Win S, Than TA, Yuan L, Abbasi SQ, Liu ZX, Kaplowitz N. PMID: 23453390.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    15. c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice. J Biol Chem. 2011 Oct 07; 286(40):35071-8. Win S, Than TA, Han D, Petrovic LM, Kaplowitz N. PMID: 21844199.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    16. Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells. J Biol Chem. 2011 Jun 24; 286(25):22047-54. Than TA, Lou H, Ji C, Win S, Kaplowitz N. PMID: 21536665.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    17. Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1. J Biol Chem. 2010 Mar 12; 285(11):8244-55. Shinohara M, Ybanez MD, Win S, Than TA, Jain S, Gaarde WA, Han D, Kaplowitz N. PMID: 20061376.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    18. Bevacizumab and chemotherapy for recurrent glioblastoma: a single-institution experience. Neurology. 2009 Apr 07; 72(14):1217-22. Nghiemphu PL, Liu W, Lee Y, Than T, Graham C, Lai A, Green RM, Pope WB, Liau LM, Mischel PS, Nelson SF, Elashoff R, Cloughesy TF. PMID: 19349600.
      View in: PubMed   Mentions: 103     Fields:    Translation:Humans
    19. Taurine chloramine: a possible oxidant reservoir. Adv Exp Med Biol. 2009; 643:451-61. Ogino T, Than TA, Hosako M, Ozaki M, Omori M, Okada S. PMID: 19239177.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    20. Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver. Alcohol Clin Exp Res. 2008 Jun; 32(6):1049-58. Ji C, Shinohara M, Vance D, Than TA, Ookhtens M, Chan C, Kaplowitz N. PMID: 18498552.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    21. Endoplasmic reticulum stress and liver injury. Semin Liver Dis. 2007 Nov; 27(4):367-77. Kaplowitz N, Than TA, Shinohara M, Ji C. PMID: 17979073.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    22. Physiological oxidants induce apoptosis and cell cycle arrest in a multidrug-resistant natural killer cell line, NK-YS. Leuk Lymphoma. 2003 Dec; 44(12):2109-16. Than TA, Ogino T, Hosako M, Omori M, Tsuchiyama J, Okada S. PMID: 14959856.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    23. Monochloramine inhibits the expression of E-selectin and intercellular adhesion molecule-1 induced by TNF-alpha through the suppression of NF-kappaB activation in human endothelial cells. Free Radic Res. 2002 Aug; 36(8):845-52. Omori M, Ogino T, Than TA, Okada S. PMID: 12420742.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    24. Monochloramine inhibits etoposide-induced apoptosis with an increase in DNA aberration. Free Radic Biol Med. 2001 Apr 15; 30(8):932-40. Than TA, Ogino T, Omori M, Okada S. PMID: 11295536.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    25. Monochloramine enhances Fas (APO-1/CD95)-induced apoptosis in Jurkat T cells. J Leukoc Biol. 2000 Jan; 67(1):46-52. Ogino T, Ma Y, Than TA, Omori M, Okada S. PMID: 10647997.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
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