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Tin A Than, PhD, MD

TitleAssistant Professor of Research Medicine
InstitutionUniversity of Southern California
DepartmentMedicine
AddressHMR 612
Health Sciences Campus
Los Angeles CA 90089-9091
Phone+1 323 442 3175
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    Dr. Than's major areas of research interest include mitochondria biogensis, stress response and mitophagy in liver patho-physiology and developmental biology, and regulation of gene expression by reactive oxygen species and derivative DNA adducts in liver patho-physiology and developmental biology. His current research entails mitochondrial retrograde signaling and stress response, and mitochondrial biogenesis in liver diseases.

    Dr. Than earned his medical degree from University of Yangon, Institute of Medicine. He then went on to earn his PhD in Free Radical Biology & Molecular Biology from Okayama University Graduate School of Medicine and Dentistry.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Win S, Than TA, Zhang J, Oo C, Min RWM, Kaplowitz N. New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases. Hepatology. 2018 May; 67(5):2013-2024. PMID: 29194686.
      View in: PubMed
    2. Zhang J, Min RWM, Le K, Zhou S, Aghajan M, Than TA, Win S, Kaplowitz N. The role of MAP2 kinases and p38 kinase in acute murine liver injury models. Cell Death Dis. 2017 06 29; 8(6):e2903. PMID: 28661486.
      View in: PubMed
    3. Huo Y, Win S, Than TA, Yin S, Ye M, Hu H, Kaplowitz N. Antcin H Protects Against Acute Liver Injury Through Disruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria. Antioxid Redox Signal. 2017 Feb 10; 26(5):207-220. PMID: 27596680.
      View in: PubMed
    4. Win S, Than TA, Min RW, Aghajan M, Kaplowitz N. c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src. Hepatology. 2016 06; 63(6):1987-2003. PMID: 26845758; PMCID: PMC4874901 [Available on 06/01/17].
    5. Kaplowitz N, Win S, Than TA, Liu ZX, Dara L. Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity. J Hepatol. 2015 Jul; 63(1):5-7. PMID: 25770661.
      View in: PubMed
    6. Win S, Than TA, Le BH, GarcĂ­a-Ruiz C, Fernandez-Checa JC, Kaplowitz N. Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity. J Hepatol. 2015 Jun; 62(6):1367-74. PMID: 25666017; PMCID: PMC4439305.
    7. Han D, Dara L, Win S, Than TA, Yuan L, Abbasi SQ, Liu ZX, Kaplowitz N. Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria. Trends Pharmacol Sci. 2013 Apr; 34(4):243-53. PMID: 23453390; PMCID: PMC3622802.
    8. Win S, Than TA, Han D, Petrovic LM, Kaplowitz N. c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice. J Biol Chem. 2011 Oct 07; 286(40):35071-8. PMID: 21844199; PMCID: PMC3186406.
    9. Than TA, Lou H, Ji C, Win S, Kaplowitz N. Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells. J Biol Chem. 2011 Jun 24; 286(25):22047-54. PMID: 21536665; PMCID: PMC3121349.
    10. Shinohara M, Ybanez MD, Win S, Than TA, Jain S, Gaarde WA, Han D, Kaplowitz N. Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1. J Biol Chem. 2010 Mar 12; 285(11):8244-55. PMID: 20061376; PMCID: PMC2832976.
    11. Ogino T, Than TA, Hosako M, Ozaki M, Omori M, Okada S. Taurine chloramine: a possible oxidant reservoir. Adv Exp Med Biol. 2009; 643:451-61. PMID: 19239177.
      View in: PubMed
    12. Ji C, Shinohara M, Vance D, Than TA, Ookhtens M, Chan C, Kaplowitz N. Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver. Alcohol Clin Exp Res. 2008 Jun; 32(6):1049-58. PMID: 18498552; PMCID: PMC2596885.
    13. Kaplowitz N, Than TA, Shinohara M, Ji C. Endoplasmic reticulum stress and liver injury. Semin Liver Dis. 2007 Nov; 27(4):367-77. PMID: 17979073.
      View in: PubMed
    14. Than TA, Ogino T, Hosako M, Omori M, Tsuchiyama J, Okada S. Physiological oxidants induce apoptosis and cell cycle arrest in a multidrug-resistant natural killer cell line, NK-YS. Leuk Lymphoma. 2003 Dec; 44(12):2109-16. PMID: 14959856.
      View in: PubMed
    15. Omori M, Ogino T, Than TA, Okada S. Monochloramine inhibits the expression of E-selectin and intercellular adhesion molecule-1 induced by TNF-alpha through the suppression of NF-kappaB activation in human endothelial cells. Free Radic Res. 2002 Aug; 36(8):845-52. PMID: 12420742.
      View in: PubMed
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