Sanda Win, MBBS, PhD

Title(s)Assistant Professor of Research Medicine
SchoolKeck School of Medicine of Usc
Address2011 Zonal Avenue, HMR 612, Mail Code:9098
Health Sciences Campus
Los Angeles CA 90089-9091
Phone+1 323 442 3175
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    Collapse Biography 
    Collapse Awards and Honors
    American Association for the Study of Liver Disease2020Presidential Poster of Distinction
    American Association for the Study of Liver Disease2020Presidential Poster of Distinction
    Baxter Foundation2018Donald E. and Delia B. Baxter Foundation Faculty Fellowship Award
    NIH2016Research Center for Liver Diseases, Keck School of Medicine of USC Research Pilot Award
    American Association for the Study of Liver Disease2014Presidential Poster of Distinction
    Sagawa Scholarship Foundation, Japan2001Award for Doctoral Program

    Collapse Overview 
    Collapse Overview
    Dr. Win's major areas of research interest are signal transduction in drug-induced hepatotoxicity, regulation of mitochondrial bioenergetic signaling in hepatotoxicity, metabolic dysfunction-associated steatotic liver disease (MASLD), and alcoholic hepatitis, oxidative stress, and identification of therapeutic targets to prevent drug-induced hepatotoxicity and metabolic dysfunction-associated steatotic liver disease (MASLD) (previous term: nonalcoholic fatty liver disease, NAFLD). Her current research includes cellular mechanisms of hepatotoxicity.

    Dr. Win earned her medical degree from University of Yangon Institute of Medicine. She then went on to perform her Medicine and Surgery Internship and Residency at University of Yangon General Hospital, followed by her PhD in Immunology & Molecular Biology from Okayama University Graduate School of Medicine and Dentistry.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mitochondrial P-JNK target, SAB (SH3BP5), in regulation of cell death. Front Cell Dev Biol. 2024; 12:1359152. Win S, Than TA, Kaplowitz N. PMID: 38559813; PMCID: PMC10978662.
      View in: PubMed   Mentions:
    2. Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolism. Cell Host Microbe. 2024 Jan 10; 32(1):48-62.e9. Li D, Chen Y, Wan M, Mei F, Wang F, Gu P, Zhang X, Wei R, Zeng Y, Zheng H, Chen B, Xiong Q, Xue T, Guan T, Guo J, Tian Y, Zeng LY, Liu Z, Yuan H, Yang L, Liu H, Dai L, Yu Y, Qiu Y, Wu P, Win S, Than TA, Wei R, Schnabl B, Kaplowitz N, Jiang Y, Ma Q, Chen P. PMID: 38056458.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. c-Jun-N Terminal Kinase-Mediated Degradation of γ-Glutamylcysteine Ligase Catalytic Subunit Inhibits GSH Recovery After Acetaminophen Treatment: Role in Sustaining JNK Activation and Liver Injury. Antioxid Redox Signal. 2023 06; 38(16-18):1071-1081. Win S, Than TA, Kaplowitz N. PMID: 36333933; PMCID: PMC10425160.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    4. Mechanism and Therapeutic Targets of c-Jun-N-Terminal Kinases Activation in Nonalcoholic Fatty Liver Disease. Biomedicines. 2022 Aug 20; 10(8). Min RWM, Aung FWM, Liu B, Arya A, Win S. PMID: 36009582; PMCID: PMC9406172.
      View in: PubMed   Mentions: 6  
    5. Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis. Hepatology. 2021 12; 74(6):3127-3145. Win S, Min RWM, Zhang J, Kanel G, Wanken B, Chen Y, Li M, Wang Y, Suzuki A, Aung FWM, Murray SF, Aghajan M, Than TA, Kaplowitz N. PMID: 34331779; PMCID: PMC8639630.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    6. Acetaminophen Hepatotoxicity: Strong Offense and Weakened Defense. Hepatology. 2020 05; 71(5):1530-1532. Kaplowitz N, Than TA, Win S. PMID: 32065403.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    7. Gut Microbiota and Liver Injury (I)-Acute Liver Injury. Adv Exp Med Biol. 2020; 1238:23-37. Wu G, Win S, Than TA, Chen P, Kaplowitz N. PMID: 32323178.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    8. Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury. J Clin Invest. 2019 12 02; 129(12):5278-5293. Win S, Min RW, Chen CQ, Zhang J, Chen Y, Li M, Suzuki A, Abdelmalek MF, Wang Y, Aghajan M, Aung FW, Diehl AM, Davis RJ, Than TA, Kaplowitz N. PMID: 31487267; PMCID: PMC6877311.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    9. Intestinal Epithelial Chemokine (C-C Motif) Ligand 7 Overexpression Enhances Acetaminophen-Induced Hepatotoxicity in Mice. Am J Pathol. 2020 01; 190(1):57-67. Niu M, Luo Z, Gong S, Win S, Kaplowitz N, Jiang Y, Chen P. PMID: 31610172; PMCID: PMC6943379.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    10. Sex Differences in Nonalcoholic Fatty Liver Disease: State of the Art and Identification of Research Gaps. Hepatology. 2019 10; 70(4):1457-1469. Lonardo A, Nascimbeni F, Ballestri S, Fairweather D, Win S, Than TA, Abdelmalek MF, Suzuki A. PMID: 30924946; PMCID: PMC6766425.
      View in: PubMed   Mentions: 300     Fields:    Translation:HumansAnimals
    11. Endoplasmic Reticulum Stress-Induced Upregulation of STARD1 Promotes Acetaminophen-Induced Acute Liver Failure. Gastroenterology. 2019 08; 157(2):552-568. Torres S, Baulies A, Insausti-Urkia N, Alarcón-Vila C, Fucho R, Solsona-Vilarrasa E, Núñez S, Robles D, Ribas V, Wakefield L, Grompe M, Lucena MI, Andrade RJ, Win S, Aung TA, Kaplowitz N, García-Ruiz C, Fernández-Checa JC. PMID: 31029706.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    12. The Regulation of JNK Signaling Pathways in Cell Death through the Interplay with Mitochondrial SAB and Upstream Post-Translational Effects. Int J Mol Sci. 2018 Nov 20; 19(11). Win S, Than TA, Kaplowitz N. PMID: 30463289; PMCID: PMC6274687.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    13. New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases. Hepatology. 2018 05; 67(5):2013-2024. Win S, Than TA, Zhang J, Oo C, Min RWM, Kaplowitz N. PMID: 29194686; PMCID: PMC5906137.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    14. Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice. J Hepatol. 2018 07; 69(1):51-59. Gong S, Lan T, Zeng L, Luo H, Yang X, Li N, Chen X, Liu Z, Li R, Win S, Liu S, Zhou H, Schnabl B, Jiang Y, Kaplowitz N, Chen P. PMID: 29524531; PMCID: PMC6365016.
      View in: PubMed   Mentions: 99     Fields:    Translation:Animals
    15. Response to: 'Professional identity in clinician-scientists: brokers between care and science'. Med Educ. 2017 12; 51(12):1294. Win S. PMID: 29124802.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. The role of MAP2 kinases and p38 kinase in acute murine liver injury models. Cell Death Dis. 2017 06 29; 8(6):e2903. Zhang J, Min RWM, Le K, Zhou S, Aghajan M, Than TA, Win S, Kaplowitz N. PMID: 28661486; PMCID: PMC5584575.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    17. Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury. Proc Natl Acad Sci U S A. 2017 04 04; 114(14):E2862-E2871. Pyzik M, Rath T, Kuo TT, Win S, Baker K, Hubbard JJ, Grenha R, Gandhi A, Krämer TD, Mezo AR, Taylor ZS, McDonnell K, Nienaber V, Andersen JT, Mizoguchi A, Blumberg L, Purohit S, Jones SD, Christianson G, Lencer WI, Sandlie I, Kaplowitz N, Roopenian DC, Blumberg RS. PMID: 28330995; PMCID: PMC5389309.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    18. Protective role of p53 in acetaminophen hepatotoxicity. Free Radic Biol Med. 2017 05; 106:111-117. Huo Y, Yin S, Yan M, Win S, Aung Than T, Aghajan M, Hu H, Kaplowitz N. PMID: 28196650; PMCID: PMC5396540.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    19. Antcin H Protects Against Acute Liver Injury Through Disruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria. Antioxid Redox Signal. 2017 02 10; 26(5):207-220. Huo Y, Win S, Than TA, Yin S, Ye M, Hu H, Kaplowitz N. PMID: 27596680; PMCID: PMC5312552.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    20. c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src. Hepatology. 2016 06; 63(6):1987-2003. Win S, Than TA, Min RW, Aghajan M, Kaplowitz N. PMID: 26845758; PMCID: PMC4874901.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    21. Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis. Hepatology. 2015 Dec; 62(6):1847-57. Dara L, Johnson H, Suda J, Win S, Gaarde W, Han D, Kaplowitz N. PMID: 26077809; PMCID: PMC4681652.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    22. Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity. J Hepatol. 2015 Jul; 63(1):5-7. Kaplowitz N, Win S, Than TA, Liu ZX, Dara L. PMID: 25770661.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    23. Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity. J Hepatol. 2015 Jun; 62(6):1367-74. Win S, Than TA, Le BH, García-Ruiz C, Fernandez-Checa JC, Kaplowitz N. PMID: 25666017; PMCID: PMC4439305.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    24. In vitro assays of mitochondrial function/dysfunction. Clin Pharmacol Ther. 2014 Dec; 96(6):665-8. Than TA, Win S, Kaplowitz N. PMID: 25207701.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    25. JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death. Cell Death Dis. 2014 Jan 09; 5:e989. Win S, Than TA, Fernandez-Checa JC, Kaplowitz N. PMID: 24407242; PMCID: PMC4040675.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    26. Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria. Trends Pharmacol Sci. 2013 Apr; 34(4):243-53. Han D, Dara L, Win S, Than TA, Yuan L, Abbasi SQ, Liu ZX, Kaplowitz N. PMID: 23453390; PMCID: PMC3622802.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    27. c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice. J Biol Chem. 2011 Oct 07; 286(40):35071-8. Win S, Than TA, Han D, Petrovic LM, Kaplowitz N. PMID: 21844199; PMCID: PMC3186406.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    28. Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells. J Biol Chem. 2011 Jun 24; 286(25):22047-54. Than TA, Lou H, Ji C, Win S, Kaplowitz N. PMID: 21536665; PMCID: PMC3121349.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    29. Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1. J Biol Chem. 2010 Mar 12; 285(11):8244-55. Shinohara M, Ybanez MD, Win S, Than TA, Jain S, Gaarde WA, Han D, Kaplowitz N. PMID: 20061376; PMCID: PMC2832976.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    30. Cryptic CTL epitope on a murine sarcoma Meth A generated by exon extension as a novel mechanism. J Immunol. 2003 May 01; 170(9):4862-8. Uenaka A, Hirano Y, Hata H, Win S, Aji T, Tanaka M, Ono T, Skipper JC, Shimizu K, Nakayama E. PMID: 12707369.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    31. Immune responses against allogeneic and syngeneic tumors in aged C57BL/6 mice. Microbiol Immunol. 2002; 46(7):513-9. Win S, Uenaka A, Nakayama E. PMID: 12222940.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    32. ELISPOT cloning of tumor antigens recognized by cytotoxic T-lymphocytes from a cDNA expression library. Cancer Immun. 2001 Jul 13; 1:8. Uenaka A, Hata H, Win S, Ono T, Wada H, Nakayama E. PMID: 12747769.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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