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    Sanda Win, MBBS, PhD

    TitleAssistant Professor of Research Medicine
    SchoolKeck School of Medicine of USC
    AddressHMR 612
    Health Sciences Campus
    Los Angeles California 90089-9091
    Phone+1 323 442 3175
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      Collapse Overview 
      Collapse Overview
      Dr. Win's major areas of research interest are signal transduction in drug-induced hepatotoxicity, regulation of mitochondrial bioenergetic signaling in hepatotoxicity, non-alcoholic steatohepatitis and alcoholic hepatitis, oxidative stress, and identification of therapeutic target to prevent drug-induced hepatotoxicity. Her current research includes cellular mechanisms of hepatotoxicity.

      Dr. Win earned her medical degree from University of Yangon Institute of Medicine. She then went on to perform her Medicine and Surgery Internship and Residency at University of Yangon General Hospital, followed by her PhD in Immunology & Molecular Biology from Okayama University Graduate School of Medicine and Dentistry.

      Collapse Biography 
      Collapse Awards and Honors
      1999  - 2001Sagawa Scholarship Award

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Zhang J, Min RWM, Le K, Zhou S, Aghajan M, Than TA, Win S, Kaplowitz N. The role of MAP2 kinases and p38 kinase in acute murine liver injury models. Cell Death Dis. 2017 Jun 29; 8(6):e2903. PMID: 28661486.
        View in: PubMed
      2. Pyzik M, Rath T, Kuo TT, Win S, Baker K, Hubbard JJ, Grenha R, Gandhi A, Krämer TD, Mezo AR, Taylor ZS, McDonnell K, Nienaber V, Andersen JT, Mizoguchi A, Blumberg L, Purohit S, Jones SD, Christianson G, Lencer WI, Sandlie I, Kaplowitz N, Roopenian DC, Blumberg RS. Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury. Proc Natl Acad Sci U S A. 2017 Apr 04; 114(14):E2862-E2871. PMID: 28330995.
        View in: PubMed
      3. Huo Y, Yin S, Yan M, Win S, Aung Than T, Aghajan M, Hu H, Kaplowitz N. Protective role of p53 in acetaminophen hepatotoxicity. Free Radic Biol Med. 2017 May; 106:111-117. PMID: 28196650.
        View in: PubMed
      4. Huo Y, Win S, Than TA, Yin S, Ye M, Hu H, Kaplowitz N. Antcin H Protects Against Acute Liver Injury Through Disruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria. Antioxid Redox Signal. 2017 Feb 10; 26(5):207-220. PMID: 27596680.
        View in: PubMed
      5. Win S, Than TA, Min RW, Aghajan M, Kaplowitz N. c-Jun N-terminal kinase mediates mouse liver injury through a novel Sab (SH3BP5)-dependent pathway leading to inactivation of intramitochondrial Src. Hepatology. 2016 Jun; 63(6):1987-2003. PMID: 26845758; PMCID: PMC4874901 [Available on 06/01/17].
      6. Dara L, Johnson H, Suda J, Win S, Gaarde W, Han D, Kaplowitz N. Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis. Hepatology. 2015 Dec; 62(6):1847-57. PMID: 26077809.
        View in: PubMed
      7. Kaplowitz N, Win S, Than TA, Liu ZX, Dara L. Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity. J Hepatol. 2015 Jul; 63(1):5-7. PMID: 25770661.
        View in: PubMed
      8. Win S, Than TA, Le BH, García-Ruiz C, Fernandez-Checa JC, Kaplowitz N. Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity. J Hepatol. 2015 Jun; 62(6):1367-74. PMID: 25666017; PMCID: PMC4439305.
      9. Than TA, Win S, Kaplowitz N. In vitro assays of mitochondrial function/dysfunction. Clin Pharmacol Ther. 2014 Dec; 96(6):665-8. PMID: 25207701.
        View in: PubMed
      10. Win S, Than TA, Fernandez-Checa JC, Kaplowitz N. JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death. Cell Death Dis. 2014 Jan 09; 5:e989. PMID: 24407242; PMCID: PMC4040675.
      11. Han D, Dara L, Win S, Than TA, Yuan L, Abbasi SQ, Liu ZX, Kaplowitz N. Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria. Trends Pharmacol Sci. 2013 Apr; 34(4):243-53. PMID: 23453390; PMCID: PMC3622802.
      12. Win S, Than TA, Han D, Petrovic LM, Kaplowitz N. c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice. J Biol Chem. 2011 Oct 07; 286(40):35071-8. PMID: 21844199; PMCID: PMC3186406.
      13. Than TA, Lou H, Ji C, Win S, Kaplowitz N. Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells. J Biol Chem. 2011 Jun 24; 286(25):22047-54. PMID: 21536665; PMCID: PMC3121349.
      14. Shinohara M, Ybanez MD, Win S, Than TA, Jain S, Gaarde WA, Han D, Kaplowitz N. Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1. J Biol Chem. 2010 Mar 12; 285(11):8244-55. PMID: 20061376; PMCID: PMC2832976.
      15. Uenaka A, Hirano Y, Hata H, Win S, Aji T, Tanaka M, Ono T, Skipper JC, Shimizu K, Nakayama E. Cryptic CTL epitope on a murine sarcoma Meth A generated by exon extension as a novel mechanism. J Immunol. 2003 May 01; 170(9):4862-8. PMID: 12707369.
        View in: PubMed
      16. Win S, Uenaka A, Nakayama E. Immune responses against allogeneic and syngeneic tumors in aged C57BL/6 mice. Microbiol Immunol. 2002; 46(7):513-9. PMID: 12222940.
        View in: PubMed