Keane Lai, MD

Title(s)Voluntary Faculty
SchoolKeck School of Medicine of Usc
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    Collapse Biography 
    Collapse Education and Training
    University of PittsburghDoctor of Medicine (MD)Medicine
    University of WashingtonResidencyClinical Pathology
    University of WashingtonFellowshipClinical Chemistry
    Collapse Awards and Honors
    American Cancer Society IRG
    Wright Foundation

    Collapse Overview 

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Heterozygous midnolin knockout attenuates severity of nonalcoholic fatty liver disease in mice fed a Western-style diet high in fat, cholesterol, and fructose. Am J Physiol Gastrointest Liver Physiol. 2023 08 01; 325(2):G147-G157. Kweon SM, Irimia-Dominguez J, Kim G, Fueger PT, Asahina K, Lai KK, Allende DS, Lai QR, Lou CH, Tsark WM, Yang JD, Ng DS, Lee JS, Tso P, Huang W, Lai KKY. PMID: 37129245; PMCID: PMC10393367.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Magnetic resonance imaging for characterization of hepatocellular carcinoma metabolism. Front Physiol. 2022; 13:1056511. Wang L, Yang JD, Yoo CC, Lai KKY, Braun J, McGovern DPB, Xie Y, Pandol SJ, Lu SC, Li D. PMID: 36589457; PMCID: PMC9800006.
      View in: PubMed   Mentions:
    3. Midnolin Regulates Liver Cancer Cell Growth In Vitro and In Vivo. Cancers (Basel). 2022 Mar 10; 14(6). Kweon SM, Kim G, Jeong Y, Huang W, Lee JS, Lai KKY. PMID: 35326575; PMCID: PMC8946164.
      View in: PubMed   Mentions: 2  
    4. Thioacetamide-Induced Norepinephrine Production by Hepatocytes is Associated with Hepatic Stellate Cell Activation and Liver Fibrosis. Curr Mol Pharmacol. 2022; 15(2):454-461. Tang WC, Chang YW, Che M, Wang MH, Lai KK, Fueger PT, Huang W, Lin SB, Lai KKY. PMID: 33845730.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Differential Kat3 Usage Orchestrates the Integration of Cellular Metabolism with Differentiation. Cancers (Basel). 2021 Nov 23; 13(23). Hu X, Ono M, Chimge NO, Chosa K, Nguyen C, Melendez E, Lou CH, Lim P, Termini J, Lai KKY, Fueger PT, Teo JL, Higuchi Y, Kahn M. PMID: 34884992; PMCID: PMC8656857.
      View in: PubMed   Mentions: 3  
    6. In Memoriam: David Bruce Endres, PhD, DABCC (1945-2021). J Appl Lab Med. 2021; 6(4):1097-1098. Jane F. Emerson, Ira A. Shulman, Allison B. Chambliss, Anthony J. Keyser, Kwok-Ming Michael Chan, Alan L. Hiti, John H. Eckfeldt, Keane K.Y. Lai. . View Publication.
    7. p300 Serine 89: A Critical Signaling Integrator and Its Effects on Intestinal Homeostasis and Repair. Cancers (Basel). 2021 Mar 14; 13(6). Lai KKY, Hu X, Chosa K, Nguyen C, Lin DP, Lai KK, Kato N, Higuchi Y, Highlander SK, Melendez E, Eriguchi Y, Fueger PT, Ouellette AJ, Chimge NO, Ono M, Kahn M. PMID: 33799418; PMCID: PMC7999107.
      View in: PubMed   Mentions: 5  
    8. Pharmacologically Targeting the WNT/β-Catenin Signaling Cascade: Avoiding the Sword of Damocles. Handb Exp Pharmacol. 2021; 269:383-422. Lai KKY, Kahn M. PMID: 34463849.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    9. Targeting the CBP/β-Catenin Interaction to Suppress Activation of Cancer-Promoting Pancreatic Stellate Cells. Cancers (Basel). 2020 Jun 05; 12(6). Che M, Kweon SM, Teo JL, Yuan YC, Melstrom LG, Waldron RT, Lugea A, Urrutia RA, Pandol SJ, Lai KKY. PMID: 32516943; PMCID: PMC7352534.
      View in: PubMed   Mentions: 9  
    10. HBV X protein mutations affect HBV transcription and association of histone-modifying enzymes with covalently closed circular DNA. Sci Rep. 2020 01 21; 10(1):802. Chong CK, Cheng CYS, Tsoi SYJ, Huang FY, Liu F, Fung J, Seto WK, Lai KK, Lai CL, Yuen MF, Wong DK. PMID: 31964944; PMCID: PMC6972884.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    11. Moderate alcohol intake promotes pancreatic ductal adenocarcinoma development in mice expressing oncogenic Kras. Am J Physiol Gastrointest Liver Physiol. 2020 02 01; 318(2):G265-G276. Asahina K, Balog S, Hwang E, Moon E, Wan E, Skrypek K, Chen Y, Fernandez J, Romo J, Yang Q, Lai K, French SW, Tsukamoto H. PMID: 31760766; PMCID: PMC7052574.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    12. Targeted genomic profiling identifies frequent deleterious mutations in FAT4 and TP53 genes in HBV-associated hepatocellular carcinoma. BMC Cancer. 2019 Aug 08; 19(1):789. Huang FY, Wong DK, Tsui VW, Seto WK, Mak LY, Cheung TT, Lai KK, Yuen MF. PMID: 31395065; PMCID: PMC6686555.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    13. The Mode of Stem Cell Division Is Dependent on the Differential Interaction of β-Catenin with the Kat3 Coactivators CBP or p300. Cancers (Basel). 2019 Jul 09; 11(7). Lukaszewicz AI, Nguyen C, Melendez E, Lin DP, Teo JL, Lai KKY, Huttner WB, Shi SH, Kahn M. PMID: 31324005; PMCID: PMC6678591.
      View in: PubMed   Mentions: 5  
    14. Animal Models: Challenges and Opportunities to Determine Optimal Experimental Models of Pancreatitis and Pancreatic Cancer. Pancreas. 2019 07; 48(6):759-779. Saloman JL, Albers KM, Cruz-Monserrate Z, Davis BM, Edderkaoui M, Eibl G, Epouhe AY, Gedeon JY, Gorelick FS, Grippo PJ, Groblewski GE, Husain SZ, Lai KKY, Pandol SJ, Uc A, Wen L, Whitcomb DC. PMID: 31206467; PMCID: PMC6581211.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    15. Convergence of Canonical and Non-Canonical Wnt Signal: Differential Kat3 Coactivator Usage. Curr Mol Pharmacol. 2019; 12(3):167-183. Lai KKY, Nguyen C, Lee KS, Lee A, Lin DP, Teo JL, Kahn M. PMID: 30836930; PMCID: PMC6687580.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    16. Nuclear receptor/Wnt beta-catenin interactions are regulated via differential CBP/p300 coactivator usage. PLoS One. 2018; 13(7):e0200714. Ono M, Lai KKY, Wu K, Nguyen C, Lin DP, Murali R, Kahn M. PMID: 30020971; PMCID: PMC6051640.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    17. Differentiation Therapy Targeting the β-Catenin/CBP Interaction in Pancreatic Cancer. Cancers (Basel). 2018 Mar 29; 10(4). Manegold P, Lai KKY, Wu Y, Teo JL, Lenz HJ, Genyk YS, Pandol SJ, Wu K, Lin DP, Chen Y, Nguyen C, Zhao Y, Kahn M. PMID: 29596326; PMCID: PMC5923350.
      View in: PubMed   Mentions: 27  
    18. Gender difference in NASH susceptibility: Roles of hepatocyte Ikkβ and Sult1e1. PLoS One. 2017; 12(8):e0181052. Matsushita N, Hassanein MT, Martinez-Clemente M, Lazaro R, French SW, Xie W, Lai K, Karin M, Tsukamoto H. PMID: 28797077; PMCID: PMC5552280.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    19. Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6. Gastroenterology. 2017 05; 152(6):1477-1491. Lai KKY, Kweon SM, Chi F, Hwang E, Kabe Y, Higashiyama R, Qin L, Yan R, Wu RP, Lai K, Fujii N, French S, Xu J, Wang JY, Murali R, Mishra L, Lee JS, Ntambi JM, Tsukamoto H. PMID: 28143772; PMCID: PMC5406249.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    20. Wnt Pathway Stabilizes MeCP2 Protein to Repress PPAR-γ in Activation of Hepatic Stellate Cells. PLoS One. 2016; 11(5):e0156111. Kweon SM, Chi F, Higashiyama R, Lai K, Tsukamoto H. PMID: 27214381; PMCID: PMC4877088.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    21. Simultaneous detection of 19 drugs of abuse on dried urine spot by liquid chromatography-tandem mass spectrometry. Clin Biochem. 2013 Aug; 46(12):1118-1124. Lee Y, Lai KKY, Sadrzadeh SMH. PMID: 23583348.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansPHPublic Health
    22. Endogenous Antibody Interferences in Immunoassays. Lab Med. 2013; 44(1):69-73. Jane F. Emerson, Keane K.Y. Lai. . View Publication.
    23. Extracellular matrix dynamics in hepatocarcinogenesis: a comparative proteomics study of PDGFC transgenic and Pten null mouse models. PLoS Genet. 2011 Jun; 7(6):e1002147. Lai KK, Shang S, Lohia N, Booth GC, Masse DJ, Fausto N, Campbell JS, Beretta L. PMID: 21731504; PMCID: PMC3121762.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    24. Improved reflexive testing algorithm for hepatitis C infection using signal-to-cutoff ratios of a hepatitis C virus antibody assay. Clin Chem. 2011 Jul; 57(7):1050-6. Lai KK, Jin M, Yuan S, Larson MF, Dominitz JA, Bankson DD. PMID: 21566071.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    25. Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK. J Hepatol. 2011 Sep; 55(3):673-682. Xu J, Lai KKY, Verlinsky A, Lugea A, French SW, Cooper MP, Ji C, Tsukamoto H. PMID: 21256905; PMCID: PMC3094601.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    26. Comprehensive and quantitative proteome profiling of the mouse liver and plasma. Hepatology. 2008 Mar; 47(3):1043-51. Lai KK, Kolippakkam D, Beretta L. PMID: 18266228.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    27. Productive replication of hepatitis C virus in perihepatic lymph nodes in vivo: implications of HCV lymphotropism. Gastroenterology. 2006 Apr; 130(4):1107-16. Pal S, Sullivan DG, Kim S, Lai KK, Kae J, Cotler SJ, Carithers RL, Wood BL, Perkins JD, Gretch DR. PMID: 16618405.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    28. Calibration curves for real-time PCR. Clin Chem. 2005 Jul; 51(7):1132-6. Lai KK, Cook L, Krantz EM, Corey L, Jerome KR. PMID: 15976098.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    29. Evaluation of real-time PCR versus PCR with liquid-phase hybridization for detection of enterovirus RNA in cerebrospinal fluid. J Clin Microbiol. 2003 Jul; 41(7):3133-41. Lai KK, Cook L, Wendt S, Corey L, Jerome KR. PMID: 12843053; PMCID: PMC165290.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    30. Sir Patrick Manson: good medicine for the people of Hong Kong. Hong Kong Med J. 2003 Apr; 9(2):145-7. Lai KK, Chan JL, Lai KK, Schmer G, Fritsche TR. PMID: 12668830.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    31. Tc-99m hexamethylpropylene amine oxime scintigraphy in the diagnosis of brain death and its implications for the harvesting of organs used for transplantation. Clin Nucl Med. 2000 Jan; 25(1):7-10. Kurtek RW, Lai KK, Tauxe WN, Eidelman BH, Fung JJ. PMID: 10634522.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    32. I-131 orthoiodohippurate assessment of renal function after heart transplantation. Clin Nucl Med. 1999 Feb; 24(2):117-9. Kurtek RW, Tauxe WN, Lai KK, Fung JJ. PMID: 9988071.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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