Michael Lansdell Paine, BSc, BDS, PhD

TitleProfessor and Director, M.S. and Ph.D. in Craniofacial Biology Program
InstitutionUniversity of Southern California
DepartmentBiomedical Engineering
AddressCSA 103
Health Sciences Campus
Los Angeles CA 90089-9062
Phone+1 323 442 1728
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    Collapse Research 
    Collapse Research Activities and Funding
    NIH/NIDCR R21DE024704Mar 1, 2016 - Feb 28, 2018
    Role: Principal Investigator
    Doctoral and Post-doctoral Training in Craniofacial Biology
    NIH/NIDCR R90DE022528Jul 1, 2011 - Jun 30, 2021
    Role: Principal Investigator
    Doctoral and Post-doctoral Training in Craniofacial Biology
    NIH/NIDCR T90DE021982Jul 1, 2011 - Jun 30, 2021
    Role: Principal Investigator
    NIH/NIDCR R01DE019629Sep 17, 2009 - Jun 30, 2015
    Role: Principal Investigator
    NIH/NIDCR R01DE014867Jul 1, 2003 - Jun 30, 2010
    Role: Principal Investigator
    NIH/NIDCR R01DE013404Mar 1, 2000 - Mar 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yin K, Paine M. Bicarbonate Transport During Enamel Maturation. Calcif Tissue Int. 2017 Nov; 101(5):457-464. PMID: 28795233.
      View in: PubMed
    2. Lacruz RS, Habelitz S, Wright JT, Paine M. DENTAL ENAMEL FORMATION AND IMPLICATIONS FOR ORAL HEALTH AND DISEASE. Physiol Rev. 2017 Jul 01; 97(3):939-993. PMID: 28468833.
      View in: PubMed
    3. Robertson SYT, Wen X, Yin K, Chen J, Smith CE, Paine M. Multiple Calcium Export Exchangers and Pumps Are a Prominent Feature of Enamel Organ Cells. Front Physiol. 2017; 8:336. PMID: 28588505.
      View in: PubMed
    4. Yin K, Guo J, Lin W, Robertson SYT, Soleimani M, Paine M. Deletion of Slc26a1 and Slc26a7 Delays Enamel Mineralization in Mice. Front Physiol. 2017; 8:307. PMID: 28559854.
      View in: PubMed
    5. Yin K, Lin W, Guo J, Sugiyama T, Snead ML, Hacia JG, Paine M. MiR-153 Regulates Amelogenesis by Targeting Endocytotic and Endosomal/lysosomal Pathways-Novel Insight into the Origins of Enamel Pathologies. Sci Rep. 2017 Mar 13; 7:44118. PMID: 28287144.
      View in: PubMed
    6. Yin K, Lei Y, Wen X, Lacruz RS, Soleimani M, Kurtz I, Snead ML, White SN, Paine M. SLC26A Gene Family Participate in pH Regulation during Enamel Maturation. PLoS One. 2015; 10(12):e0144703. PMID: 26671068; PMCID: PMC4679777.
    7. Sarkar J, Wen X, Simanian EJ, Paine M. V-type ATPase proton pump expression during enamel formation. Matrix Biol. 2016 May-Jul; 52-54:234-245. PMID: 26586472; PMCID: PMC4867139 [Available on 05/01/17].
    8. Nurbaeva MK, Eckstein M, Concepcion AR, Smith CE, Srikanth S, Paine M, Gwack Y, Hubbard MJ, Feske S, Lacruz RS. Dental enamel cells express functional SOCE channels. Sci Rep. 2015 Oct 30; 5:15803. PMID: 26515404; PMCID: PMC4626795.
    9. Geng S, White SN, Paine M, Snead ML. Protein Interaction between Ameloblastin and Proteasome Subunit a Type 3 Can Facilitate Redistribution of Ameloblastin Domains within Forming Enamel. J Biol Chem. 2015 Aug 21; 290(34):20661-73. PMID: 26070558; PMCID: PMC4543628.
    10. Moshaverinia A, Chen C, Xu X, Ansari S, Zadeh HH, Schricker SR, Paine M, Moradian-Oldak J, Khademhosseini A, Snead ML, Shi S. Regulation of the Stem Cell-Host Immune System Interplay Using Hydrogel Coencapsulation System with an Anti-Inflammatory Drug. Adv Funct Mater. 2015 Apr 15; 25(15):2296-2307. PMID: 26120294.
      View in: PubMed
    11. Wen X, Lacruz RS, Paine M. Dental and Cranial Pathologies in Mice Lacking the Cl(-) /H(+) -Exchanger ClC-7. Anat Rec (Hoboken). 2015 Aug; 298(8):1502-8. PMID: 25663454; PMCID: PMC4503507.
    12. Yin K, Hacia JG, Zhong Z, Paine M. Genome-wide analysis of miRNA and mRNA transcriptomes during amelogenesis. BMC Genomics. 2014 Nov 19; 15:998. PMID: 25406666; PMCID: PMC4254193.
    13. Sarkar J, Simanian EJ, Tuggy SY, Bartlett JD, Snead ML, Sugiyama T, Paine M. Comparison of two mouse ameloblast-like cell lines for enamel-specific gene expression. Front Physiol. 2014; 5:277. PMID: 25120490; PMCID: PMC4110967.
    14. Wen X, Kurtz I, Paine M. Prevention of the disrupted enamel phenotype in Slc4a4-null mice using explant organ culture maintained in a living host kidney capsule. PLoS One. 2014; 9(5):e97318. PMID: 24828138; PMCID: PMC4020772.
    15. Wen X, Lacruz RS, Smith CE, Paine M. Gene-expression profile and localization of Na+/K(+)-ATPase in rat enamel organ cells. Eur J Oral Sci. 2014 Feb; 122(1):21-6. PMID: 24313748; PMCID: PMC4005357.
    16. Li X, Venugopalan SR, Cao H, Pinho FO, Paine M, Snead ML, Semina EV, Amendt BA. A model for the molecular underpinnings of tooth defects in Axenfeld-Rieger syndrome. Hum Mol Genet. 2014 Jan 01; 23(1):194-208. PMID: 23975681; PMCID: PMC3857954.
    17. Lacruz RS, de Castro JM, MartinĂ³n-Torres M, O'Higgins P, Paine M, Carbonell E, Arsuaga JL, Bromage TG. Facial morphogenesis of the earliest europeans. PLoS One. 2013; 8(6):e65199. PMID: 23762314; PMCID: PMC3675139.
    18. Lacruz RS, Brookes SJ, Wen X, Jimenez JM, Vikman S, Hu P, White SN, Lyngstadaas SP, Okamoto CT, Smith CE, Paine M. Adaptor protein complex 2-mediated, clathrin-dependent endocytosis, and related gene activities, are a prominent feature during maturation stage amelogenesis. J Bone Miner Res. 2013 Mar; 28(3):672-87. PMID: 23044750; PMCID: PMC3562759.
    19. Gibson MP, Liu Q, Zhu Q, Lu Y, Jani P, Wang X, Liu Y, Paine M, Snead ML, Feng JQ, Qin C. Role of the NH2 -terminal fragment of dentin sialophosphoprotein in dentinogenesis. Eur J Oral Sci. 2013 Apr; 121(2):76-85. PMID: 23489896; PMCID: PMC3602929.
    20. Wen X, Paine M. Iron deposition and ferritin heavy chain (Fth) localization in rodent teeth. BMC Res Notes. 2013 Jan 02; 6:1. PMID: 23281703; PMCID: PMC3556315.
    21. Lees JD, Robinson C, Shore RC, Paine M, Brookes SJ. Cellular uptake and processing of enamel matrix derivative by human periodontal ligament fibroblasts. Arch Oral Biol. 2013 Apr; 58(4):348-54. PMID: 22939369; PMCID: PMC3587288.
    22. Hu P, Lacruz RS, Smith CE, Smith SM, Kurtz I, Paine M. Expression of the sodium/calcium/potassium exchanger, NCKX4, in ameloblasts. Cells Tissues Organs. 2012; 196(6):501-9. PMID: 22677781; PMCID: PMC3535175.
    23. Lacruz RS, Hacia JG, Bromage TG, Boyde A, Lei Y, Xu Y, Miller JD, Paine M, Snead ML. The circadian clock modulates enamel development. J Biol Rhythms. 2012 Jun; 27(3):237-45. PMID: 22653892; PMCID: PMC3511783.
    24. Lacruz RS, Smith CE, Bringas P, Chen YB, Smith SM, Snead ML, Kurtz I, Hacia JG, Hubbard MJ, Paine M. Identification of novel candidate genes involved in mineralization of dental enamel by genome-wide transcript profiling. J Cell Physiol. 2012 May; 227(5):2264-75. PMID: 21809343; PMCID: PMC3243804.
    25. Lacruz RS, Nakayama Y, Holcroft J, Nguyen V, Somogyi-Ganss E, Snead ML, White SN, Paine M, Ganss B. Targeted overexpression of amelotin disrupts the microstructure of dental enamel. PLoS One. 2012; 7(4):e35200. PMID: 22539960; PMCID: PMC3335167.
    26. Lacruz RS, Smith CE, Moffatt P, Chang EH, Bromage TG, Bringas P, Nanci A, Baniwal SK, Zabner J, Welsh MJ, Kurtz I, Paine M. Requirements for ion and solute transport, and pH regulation during enamel maturation. J Cell Physiol. 2012 Apr; 227(4):1776-85. PMID: 21732355; PMCID: PMC3373187.
    27. Tamburstuen MV, Snead ML, Reseland JE, Paine M, Lyngstadaas SP. Ameloblastin upstream region contains structural elements regulating transcriptional activity in a stromal cell line derived from bone marrow. Eur J Oral Sci. 2011 Dec; 119 Suppl 1:286-92. PMID: 22243258; PMCID: PMC3370392.
    28. Lacruz RS, Smith CE, Chen YB, Hubbard MJ, Hacia JG, Paine M. Gene-expression analysis of early- and late-maturation-stage rat enamel organ. Eur J Oral Sci. 2011 Dec; 119 Suppl 1:149-57. PMID: 22243241; PMCID: PMC3286129.
    29. Snead CM, Smith SM, Sadeghein N, Lacruz RS, Hu P, Kurtz I, Paine M. Identification of a pH-responsive DNA region upstream of the transcription start site of human NBCe1-B. Eur J Oral Sci. 2011 Dec; 119 Suppl 1:136-41. PMID: 22243239; PMCID: PMC3374727.
    30. Chang EH, Lacruz RS, Bromage TG, Bringas P, Welsh MJ, Zabner J, Paine M. Enamel pathology resulting from loss of function in the cystic fibrosis transmembrane conductance regulator in a porcine animal model. Cells Tissues Organs. 2011; 194(2-4):249-54. PMID: 21525720; PMCID: PMC3178086.
    31. Lacruz RS, Lakshminarayanan R, Bromley KM, Hacia JG, Bromage TG, Snead ML, Moradian-Oldak J, Paine M. Structural analysis of a repetitive protein sequence motif in strepsirrhine primate amelogenin. PLoS One. 2011 Mar 18; 6(3):e18028. PMID: 21437261; PMCID: PMC3060920.
    32. Snead ML, Zhu DH, Lei Y, Luo W, Bringas PO, Sucov HM, Rauth RJ, Paine M, White SN. A simplified genetic design for mammalian enamel. Biomaterials. 2011 Apr; 32(12):3151-7. PMID: 21295848; PMCID: PMC3045652.
    33. Lacruz RS, Nanci A, White SN, Wen X, Wang H, Zalzal SF, Luong VQ, Schuetter VL, Conti PS, Kurtz I, Paine M. The sodium bicarbonate cotransporter (NBCe1) is essential for normal development of mouse dentition. J Biol Chem. 2010 Aug 06; 285(32):24432-8. PMID: 20529845; PMCID: PMC2915679.
    34. Lacruz RS, Hilvo M, Kurtz I, Paine M. A survey of carbonic anhydrase mRNA expression in enamel cells. Biochem Biophys Res Commun. 2010 Mar 19; 393(4):883-7. PMID: 20175995; PMCID: PMC2843801.
    35. Lacruz RS, Nanci A, Kurtz I, Wright JT, Paine M. Regulation of pH During Amelogenesis. Calcif Tissue Int. 2010 Feb; 86(2):91-103. PMID: 20016979; PMCID: PMC2809306.
    36. Rauth RJ, Potter KS, Ngan AY, Saad DM, Mehr R, Luong VQ, Schuetter VL, Miklus VG, Chang P, Paine M, Lacruz RS, Snead ML, White SN. Dental enamel: genes define biomechanics. J Calif Dent Assoc. 2009 Dec; 37(12):863-8. PMID: 20066874; PMCID: PMC2825347.
    37. Tannukit S, Crabb TL, Hertel KJ, Wen X, Jans DA, Paine M. Identification of a novel nuclear localization signal and speckle-targeting sequence of tuftelin-interacting protein 11, a splicing factor involved in spliceosome disassembly. Biochem Biophys Res Commun. 2009 Dec 18; 390(3):1044-50. PMID: 19857462; PMCID: PMC2787706.
    38. Wen X, Tannukit S, Paine M. TFIP11 interacts with mDEAH9, an RNA helicase involved in spliceosome disassembly. Int J Mol Sci. 2008 Nov; 9(11):2105-13. PMID: 19165350; PMCID: PMC2629433.
    39. Wen X, Zou Y, Luo W, Goldberg M, Moats R, Conti PS, Snead ML, Paine M. Biglycan overexpression on tooth enamel formation in transgenic mice. Anat Rec (Hoboken). 2008 Oct; 291(10):1246-53. PMID: 18727043; PMCID: PMC2562349.
    40. Tannukit S, Wen X, Wang H, Paine M. TFIP11, CCNL1 and EWSR1 Protein-protein Interactions, and Their Nuclear Localization. Int J Mol Sci. 2008 Aug; 9(8):1504-14. PMID: 19122807; PMCID: PMC2605624.
    41. Zou Y, Wang H, Shapiro JL, Okamoto CT, Brookes SJ, Lyngstadaas SP, Snead ML, Paine M. Determination of protein regions responsible for interactions of amelogenin with CD63 and LAMP1. Biochem J. 2007 Dec 15; 408(3):347-54. PMID: 17708745; PMCID: PMC2267358.
    42. Dalrymple KR, Wong S, Rosenblum A, Wuenschell C, Paine M, Shuler CF. PBL Core Skills Faculty Development Workshop 3: understanding PBL process assessment and feedback via scenario-based discussions, observation, and role-play. J Dent Educ. 2007 Dec; 71(12):1561-73. PMID: 18096882.
      View in: PubMed
    43. Tarasevich BJ, Howard CJ, Larson JL, Snead ML, Simmer JP, Paine M, Shaw WJ. The nucleation and growth of calcium phosphate by amelogenin. J Cryst Growth. 2007 Jun 15; 304(2):407-415. PMID: 19079557.
      View in: PubMed
    44. Dalrymple KR, Wuenschell C, Rosenblum A, Paine M, Crowe D, von Bergmann HC, Wong S, Bradford MS, Shuler CF. PBL core skills faculty development workshop 1: An experiential exercise with the PBL process. J Dent Educ. 2007 Feb; 71(2):249-59. PMID: 17314387.
      View in: PubMed
    45. White SN, Paine M, Ngan AY, Miklus VG, Luo W, Wang H, Snead ML. Ectopic expression of dentin sialoprotein during amelogenesis hardens bulk enamel. J Biol Chem. 2007 Feb 23; 282(8):5340-5. PMID: 17189271.
      View in: PubMed
    46. Zhu D, Paine M, Luo W, Bringas P, Snead ML. Altering biomineralization by protein design. J Biol Chem. 2006 Jul 28; 281(30):21173-82. PMID: 16707492.
      View in: PubMed
    47. Swanson EC, Fong HK, Foster BL, Paine M, Gibson CW, Snead ML, Somerman MJ. Amelogenins regulate expression of genes associated with cementoblasts in vitro. Eur J Oral Sci. 2006 May; 114 Suppl 1:239-43; discussion 254-6, 381-2. PMID: 16674692.
      View in: PubMed
    48. Wang HJ, Tannukit S, Wen X, Shapiro JL, Snead ML, Paine M. Using the yeast two-hybrid assay to discover protein partners for the leucine-rich amelogenin peptide and for tuftelin-interacting protein 11. Eur J Oral Sci. 2006 May; 114 Suppl 1:276-9; discussion 285-6, 382. PMID: 16674698.
      View in: PubMed
    49. Bartlett JD, Ganss B, Goldberg M, Moradian-Oldak J, Paine M, Snead ML, Wen X, White SN, Zhou YL. 3. Protein-protein interactions of the developing enamel matrix. Curr Top Dev Biol. 2006; 74:57-115. PMID: 16860665.
      View in: PubMed
    50. Shapiro JL, Wang H, Wen X, Tannukit S, Paine M. An amelogenin minigene to study alternative splicing. DNA Cell Biol. 2006 Jan; 25(1):1-5. PMID: 16405395.
      View in: PubMed
    51. Bartold PM, Xiao Y, Lyngstaadas SP, Paine M, Snead ML. Principles and applications of cell delivery systems for periodontal regeneration. Periodontol 2000. 2006; 41:123-35. PMID: 16686930.
      View in: PubMed
    52. Yin Y, Huang J, Paine M, Reinhold VN, Chasteen ND. Structural characterization of the major extrapallial fluid protein of the mollusc Mytilus edulis: implications for function. Biochemistry. 2005 Aug 09; 44(31):10720-31. PMID: 16060681.
      View in: PubMed
    53. Paine M, Luo W, Wang HJ, Bringas P, Ngan AY, Miklus VG, Zhu DH, MacDougall M, White SN, Snead ML. Dentin sialoprotein and dentin phosphoprotein overexpression during amelogenesis. J Biol Chem. 2005 Sep 09; 280(36):31991-8. PMID: 16014627.
      View in: PubMed
    54. Wang H, Tannukit S, Zhu D, Snead ML, Paine M. Enamel matrix protein interactions. J Bone Miner Res. 2005 Jun; 20(6):1032-40. PMID: 15883644.
      View in: PubMed
    55. Shaw WJ, Campbell AA, Paine M, Snead ML. The COOH terminus of the amelogenin, LRAP, is oriented next to the hydroxyapatite surface. J Biol Chem. 2004 Sep 24; 279(39):40263-6. PMID: 15299015.
      View in: PubMed
    56. Paine M, Paine CT, Machin GA. Hair whorls and monozygosity. J Invest Dermatol. 2004 Apr; 122(4):1057-8. PMID: 15102099.
      View in: PubMed
    57. Paine M, Zhu DH, Luo W, Snead ML. Overexpression of TRAP in the enamel matrix does not alter the enamel structural hierarchy. Cells Tissues Organs. 2004; 176(1-3):7-16. PMID: 14745231.
      View in: PubMed
    58. Luo W, Wen X, Wang HJ, MacDougall M, Snead ML, Paine M. In vivo overexpression of tuftelin in the enamel organic matrix. Cells Tissues Organs. 2004; 177(4):212-20. PMID: 15459477.
      View in: PubMed
    59. Fong H, White SN, Paine M, Luo W, Snead ML, Sarikaya M. Enamel structure properties controlled by engineered proteins in transgenic mice. J Bone Miner Res. 2003 Nov; 18(11):2052-9. PMID: 14606519.
      View in: PubMed
    60. Paine M, Wang HJ, Luo W, Krebsbach PH, Snead ML. A transgenic animal model resembling amelogenesis imperfecta related to ameloblastin overexpression. J Biol Chem. 2003 May 23; 278(21):19447-52. PMID: 12657627.
      View in: PubMed
    61. Paine M, Luo W, Zhu DH, Bringas P, Snead ML. Functional domains for amelogenin revealed by compound genetic defects. J Bone Miner Res. 2003 Mar; 18(3):466-72. PMID: 12619931.
      View in: PubMed
    62. Paine M, Wang HJ, Snead ML. Amelogenin self-assembly and the role of the proline located within the carboxyl-teleopeptide. Connect Tissue Res. 2003; 44 Suppl 1:52-7. PMID: 12952174.
      View in: PubMed
    63. Paine M, Lei YP, Dickerson K, Snead ML. Altered amelogenin self-assembly based on mutations observed in human X-linked amelogenesis imperfecta (AIH1). J Biol Chem. 2002 May 10; 277(19):17112-6. PMID: 11877393.
      View in: PubMed
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