Jinseok Park

Title(s)Assistant Professor of Pediatrics
Address4640 West Sunset Blvd
Off Campus
Los Angeles CA 90027
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    Johns Hopkins University, Baltimore, MDPh.D.06/2014Biomedical Engineering
    Yale University, New Haven, CTPostdoc04/2020Biomedical Engineering

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    I have investigated cancer development from the perspective of cancer cell biology and mechanobiology. Cancer cells actively modify tumor microenvironment (TME) for tumor progression. Extracellular matrix (ECM), a major component of TME supporting embedded cells physically in the tissue, undergoes re-organization by cancer cells. The reorganized ECM reciprocally regulates cancer-related phenotypes such as invasive migration facilitating tumor progression. This suggests that the elucidation of cancer cell-ECM interaction can provide important cues to understanding cancer promoting mechanism and thus improving cancer treatment. Therefore, as leveraging in vitro ECM models wish nanofabricated surfaces or 3D model, our lab aims to address how cancer cell-ECM interaction stimulates cancer-promoting phenotypes such as invasive cell migration and heterogeneous cell-cell interaction synergically with oncogenic alteration.
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and Rho-family GTPases. Nat Commun. 2019 06 26; 10(1):2797. Park J, Kim DH, Shah SR, Kim HN, Kshitiz , Kim P, Quiñones-Hinojosa A, Levchenko A. PMID: 31243273.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    2. Biomechanical interplay between anisotropic re-organization of cells and the surrounding matrix underlies transition to invasive cancer spread. Sci Rep. 2018 09 21; 8(1):14210. Kim DH, Ewald AJ, Park J, Kshitiz , Kwak M, Gray RS, Su CY, Seo J, An SS, Levchenko A. PMID: 30242256.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    3. Topotaxis: A New Mechanism of Directed Cell Migration in Topographic ECM Gradients. Biophys J. 2018 03 27; 114(6):1257-1263. Park J, Kim DH, Levchenko A. PMID: 29590582.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    4. Mechanochemical feedback underlies coexistence of qualitatively distinct cell polarity patterns within diverse cell populations. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):E5750-E5759. Park J, Holmes WR, Lee SH, Kim HN, Kim DH, Kwak MK, Wang CJ, Edelstein-Keshet L, Levchenko A. PMID: 28655842.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    5. Combined HMG-COA reductase and prenylation inhibition in treatment of CCM. Proc Natl Acad Sci U S A. 2017 05 23; 114(21):5503-5508. Nishimura S, Mishra-Gorur K, Park J, Surovtseva YV, Sebti SM, Levchenko A, Louvi A, Gunel M. PMID: 28500274.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    6. A mathematical model coupling polarity signaling to cell adhesion explains diverse cell migration patterns. PLoS Comput Biol. 2017 05; 13(5):e1005524. Holmes WR, Park J, Levchenko A, Edelstein-Keshet L. PMID: 28472054.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    7. Migration Phenotype of Brain-Cancer Cells Predicts Patient Outcomes. Cell Rep. 2016 06 21; 15(12):2616-24. Smith CL, Kilic O, Schiapparelli P, Guerrero-Cazares H, Kim DH, Sedora-Roman NI, Gupta S, O'Donnell T, Chaichana KL, Rodriguez FJ, Abbadi S, Park J, Quiñones-Hinojosa A, Levchenko A. PMID: 27292647.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    8. Directed migration of cancer cells guided by the graded texture of the underlying matrix. Nat Mater. 2016 07; 15(7):792-801. Park J, Kim DH, Kim HN, Wang CJ, Kwak MK, Hur E, Suh KY, An SS, Levchenko A. PMID: 26974411.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    9. Precisely parameterized experimental and computational models of tissue organization. Integr Biol (Camb). 2016 Feb; 8(2):230-242. Molitoris JM, Paliwal S, Sekar RB, Blake R, Park J, Trayanova NA, Tung L, Levchenko A. PMID: 26822672.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    10. Notch signaling mediates melanoma-endothelial cell communication and melanoma cell migration. Pigment Cell Melanoma Res. 2013 Sep; 26(5):697-707. Howard JD, Moriarty WF, Park J, Riedy K, Panova IP, Chung CH, Suh KY, Levchenko A, Alani RM. PMID: 23773728.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    11. Control of stem cell fate and function by engineering physical microenvironments. Integr Biol (Camb). 2012 Sep; 4(9):1008-18. Kshitiz , Park J, Kim P, Helen W, Engler AJ, Levchenko A, Kim DH. PMID: 23077731.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    12. Quantitative analysis of the combined effect of substrate rigidity and topographic guidance on cell morphology. IEEE Trans Nanobioscience. 2012 Mar; 11(1):28-36. Park J, Kim HN, Kim DH, Levchenko A, Suh KY. PMID: 21908261.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
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