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Laura Perin Gallandt, PhD

Title(s)Assistant Professor of Research Urology
Phone+1 323 361 2247
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    Laura Perin, MD, is an Assistant Professor at Keck School of Medicine, University of Southern California. Before joining the faculty at USC she was a research fellow at Harvard School of Medicine, where she obtained her PhD, and a postdoctoral fellow at Children Hospital of Los Angeles. She is a recipient of many intramural and extramural awards including CIRM, American Urology Foundation, Alport Foundation, etc. Her research focuses on the application of human and mouse amniotic fluid
    stem cells (AFSC) in animal models of acute and chronic kidney, pancreas and lung. In addition, Dr. Perin is investigating the mechanism of action of stem cells and how AFSC provide organ protection thorough their modulatory effects.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Gazia C, Tamburrini R, Asthana A, Chaimov D, Muir SM, Marino DI, Delbono L, Villani V, Perin L, Di Nardo P, Robertson J, Orlando G. Extracellular matrix-based hydrogels obtained from human tissues: a work still in progress. Curr Opin Organ Transplant. 2019 Aug 19. PMID: 31433307.
      View in: PubMed
    2. Petrosyan A, Cravedi P, Villani V, Angeletti A, Manrique J, Renieri A, De Filippo RE, Perin L, Da Sacco S. A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier. Nat Commun. 2019 Aug 13; 10(1):3656. PMID: 31409793.
      View in: PubMed
    3. Fribourg M, Anderson L, Fischman C, Cantarelli C, Perin L, La Manna G, Rahman A, Burrell BE, Heeger PS, Cravedi P. T-cell exhaustion correlates with improved outcomes in kidney transplant recipients. Kidney Int. 2019 Feb 27. PMID: 31040060.
      View in: PubMed
    4. Marcheque J, Bussolati B, Csete M, Perin L. Concise Reviews: Stem Cells and Kidney Regeneration: An Update. Stem Cells Transl Med. 2019 Jan; 8(1):82-92. PMID: 30302937.
      View in: PubMed
    5. Gandolfini I, Crespo E, Baweja M, Jarque M, Donadei C, Luque S, Montero N, Allesina A, Perin L, Maggiore U, Cravedi P, Bestard O. Impact of preformed T-cell alloreactivity by means of donor-specific and panel of reactive T cells (PRT) ELISPOT in kidney transplantation. PLoS One. 2018; 13(7):e0200696. PMID: 30059561.
      View in: PubMed
    6. Sedrakyan S, Villani V, Da Sacco S, Tripuraneni N, Porta S, Achena A, Lavarreda-Pearce M, Petrosyan A, Soloyan H, Filippo RE, Bussolati B, Perin L. Amniotic fluid stem cell-derived vesicles protect from VEGF-induced endothelial damage. Sci Rep. 2017 Dec 04; 7(1):16875. PMID: 29203902.
      View in: PubMed
    7. Cravedi P, Farouk S, Angeletti A, Edgar L, Tamburrini R, Duisit J, Perin L, Orlando G. Regenerative immunology: the immunological reaction to biomaterials. Transpl Int. 2017 Dec; 30(12):1199-1208. PMID: 28892571.
      View in: PubMed
    8. Milanesi A, Lee JW, Yang A, Liu YY, Sedrakyan S, Cheng SY, Perin L, Brent GA. Thyroid Hormone Receptor Alpha is Essential to Maintain the Satellite Cell Niche During Skeletal Muscle Injury and Sarcopenia of Aging. Thyroid. 2017 10; 27(10):1316-1322. PMID: 28847239.
      View in: PubMed
    9. Da Sacco S, Perin L, Sedrakyan S. Amniotic fluid cells: current progress and emerging challenges in renal regeneration. Pediatr Nephrol. 2018 Jun; 33(6):935-945. PMID: 28620747.
      View in: PubMed
    10. Gross O, Kashtan CE, Rheault MN, Flinter F, Savige J, Miner JH, Torra R, Ars E, Deltas C, Savva I, Perin L, Renieri A, Ariani F, Mari F, Baigent C, Judge P, Knebelman B, Heidet L, Lagas S, Blatt D, Ding J, Zhang Y, Gale DP, Prunotto M, Xue Y, Schachter AD, Morton LCG, Blem J, Huang M, Liu S, Vallee S, Renault D, Schifter J, Skelding J, Gear S, Friede T, Turner AN, Lennon R. Advances and unmet needs in genetic, basic and clinical science in Alport syndrome: report from the 2015 International Workshop on Alport Syndrome. Nephrol Dial Transplant. 2017 Jun 01; 32(6):916-924. PMID: 27190345.
      View in: PubMed
    11. Cheng CW, Villani V, Buono R, Wei M, Kumar S, Yilmaz OH, Cohen P, Sneddon JB, Perin L, Longo VD. Fasting-Mimicking Diet Promotes Ngn3-Driven ß-Cell Regeneration to Reverse Diabetes. Cell. 2017 02 23; 168(5):775-788.e12. PMID: 28235195.
      View in: PubMed
    12. Da Sacco S, Thornton ME, Petrosyan A, Lavarreda-Pearce M, Sedrakyan S, Grubbs BH, De Filippo RE, Perin L. Direct Isolation and Characterization of Human Nephron Progenitors. Stem Cells Transl Med. 2017 Feb; 6(2):419-433. PMID: 28191781.
      View in: PubMed
    13. Petrosyan A, Da Sacco S, Tripuraneni N, Kreuser U, Lavarreda-Pearce M, Tamburrini R, De Filippo RE, Orlando G, Cravedi P, Perin L. A step towards clinical application of acellular matrix: A clue from macrophage polarization. Matrix Biol. 2017 01; 57-58:334-346. PMID: 27575985.
      View in: PubMed
    14. Peloso A, Tamburrini R, Edgar L, Wilm B, Katari R, Perin L, Murray P, Orlando G. Extracellular matrix scaffolds as a platform for kidney regeneration. Eur J Pharmacol. 2016 Nov 05; 790:21-27. PMID: 27455902.
      View in: PubMed
    15. Petrosyan A, Zanusso I, Lavarreda-Pearce M, Leslie S, Sedrakyan S, De Filippo RE, Orlando G, Da Sacco S, Perin L. Decellularized Renal Matrix and Regenerative Medicine of the Kidney: A Different Point of View. Tissue Eng Part B Rev. 2016 06; 22(3):183-92. PMID: 26653996.
      View in: PubMed
    16. Milanesi A, Lee JW, Kim NH, Liu YY, Yang A, Sedrakyan S, Kahng A, Cervantes V, Tripuraneni N, Cheng SY, Perin L, Brent GA. Thyroid Hormone Receptor a Plays an Essential Role in Male Skeletal Muscle Myoblast Proliferation, Differentiation, and Response to Injury. Endocrinology. 2016 Jan; 157(1):4-15. PMID: 26451739; PMCID: PMC4701883 [Available on 01/01/17].
    17. Katari R, Edgar L, Wong T, Boey A, Mancone S, Igel D, Callese T, Voigt M, Tamburrini R, Zambon JP, Perin L, Orlando G. Tissue-Engineering Approaches to Restore Kidney Function. Curr Diab Rep. 2015 Oct; 15(10):69. PMID: 26275443.
      View in: PubMed
    18. Peloso A, Petrosyan A, Da Sacco S, Booth C, Zambon JP, O'Brien T, Aardema C, Robertson J, De Filippo RE, Soker S, Stratta RJ, Perin L, Orlando G. Renal Extracellular Matrix Scaffolds From Discarded Kidneys Maintain Glomerular Morphometry and Vascular Resilience and Retains Critical Growth Factors. Transplantation. 2015 Sep; 99(9):1807-16. PMID: 26018349.
      View in: PubMed
    19. Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab. 2015 Jul 07; 22(1):86-99. PMID: 26094889.
      View in: PubMed
    20. Gross O, Perin L, Deltas C. Alport syndrome from bench to bedside: the potential of current treatment beyond RAAS blockade and the horizon of future therapies. Nephrol Dial Transplant. 2014 Sep; 29 Suppl 4:iv124-30. PMID: 25165179.
      View in: PubMed
    21. Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS, Da Sacco S, Mirisola M, Quinn DI, Dorff TB, Kopchick JJ, Longo VD. Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell. 2014 Jun 05; 14(6):810-23. PMID: 24905167; PMCID: PMC4102383.
    22. Da Sacco S, Lemley KV, Sedrakyan S, Zanusso I, Petrosyan A, Peti-Peterdi J, Burford J, De Filippo RE, Perin L. A novel source of cultured podocytes. PLoS One. 2013; 8(12):e81812. PMID: 24349133.
      View in: PubMed
    23. Villani V, Milanesi A, Sedrakyan S, Da Sacco S, Angelow S, Conconi MT, Di Liddo R, De Filippo R, Perin L. Amniotic fluid stem cells prevent ß-cell injury. Cytotherapy. 2014 Jan; 16(1):41-55. PMID: 24210784.
      View in: PubMed
    24. Garcia O, Carraro G, Turcatel G, Hall M, Sedrakyan S, Roche T, Buckley S, Driscoll B, Perin L, Warburton D. Amniotic fluid stem cells inhibit the progression of bleomycin-induced pulmonary fibrosis via CCL2 modulation in bronchoalveolar lavage. PLoS One. 2013; 8(8):e71679. PMID: 23967234.
      View in: PubMed
    25. Milanesi A, Lee JW, Li Z, Da Sacco S, Villani V, Cervantes V, Perin L, Yu JS. ß-Cell regeneration mediated by human bone marrow mesenchymal stem cells. PLoS One. 2012; 7(8):e42177. PMID: 22879915; PMCID: PMC3413696.
    26. Sedrakyan S, Da Sacco S, Milanesi A, Shiri L, Petrosyan A, Varimezova R, Warburton D, Lemley KV, De Filippo RE, Perin L. Injection of amniotic fluid stem cells delays progression of renal fibrosis. J Am Soc Nephrol. 2012 Apr; 23(4):661-73. PMID: 22302195.
      View in: PubMed
    27. Sedrakyan S, Angelow S, De Filippo RE, Perin L. Stem cells as a therapeutic approach to chronic kidney diseases. Curr Urol Rep. 2012 Feb; 13(1):47-54. PMID: 22127675.
      View in: PubMed
    28. Buckley S, Shi W, Carraro G, Sedrakyan S, Da Sacco S, Driscoll BA, Perin L, De Filippo RE, Warburton D. The milieu of damaged alveolar epithelial type 2 cells stimulates alveolar wound repair by endogenous and exogenous progenitors. Am J Respir Cell Mol Biol. 2011 Dec; 45(6):1212-21. PMID: 21700959.
      View in: PubMed
    29. Milanesi A, Lee JW, Xu Q, Perin L, Yu JS. Differentiation of nestin-positive cells derived from bone marrow into pancreatic endocrine and ductal cells in vitro. J Endocrinol. 2011 May; 209(2):193-201. PMID: 21330336.
      View in: PubMed
    30. Da Sacco S, De Filippo RE, Perin L. Amniotic fluid as a source of pluripotent and multipotent stem cells for organ regeneration. Curr Opin Organ Transplant. 2011 Feb; 16(1):101-5. PMID: 21157345.
      View in: PubMed
    31. Perin L, Da Sacco S, De Filippo RE. Regenerative medicine of the kidney. Adv Drug Deliv Rev. 2011 Apr 30; 63(4-5):379-87. PMID: 21145933.
      View in: PubMed
    32. Perin L, Sedrakyan S, Giuliani S, Da Sacco S, Carraro G, Shiri L, Lemley KV, Rosol M, Wu S, Atala A, Warburton D, De Filippo RE. Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis. PLoS One. 2010 Feb 24; 5(2):e9357. PMID: 20195358.
      View in: PubMed
    33. Da Sacco S, Sedrakyan S, Boldrin F, Giuliani S, Parnigotto P, Habibian R, Warburton D, De Filippo RE, Perin L. Human amniotic fluid as a potential new source of organ specific precursor cells for future regenerative medicine applications. J Urol. 2010 Mar; 183(3):1193-200. PMID: 20096867.
      View in: PubMed
    34. Carraro G, Perin L, Sedrakyan S, Giuliani S, Tiozzo C, Lee J, Turcatel G, De Langhe SP, Driscoll B, Bellusci S, Minoo P, Atala A, De Filippo RE, Warburton D. Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages. Stem Cells. 2008 Nov; 26(11):2902-11. PMID: 18719226.
      View in: PubMed
    35. Warburton D, Perin L, Defilippo R, Bellusci S, Shi W, Driscoll B. Stem/progenitor cells in lung development, injury repair, and regeneration. Proc Am Thorac Soc. 2008 Aug 15; 5(6):703-6. PMID: 18684721; PMCID: PMC2645263.
    36. Yamzon J, Perin L, Koh CJ. Current status of tissue engineering in pediatric urology. Curr Opin Urol. 2008 Jul; 18(4):404-7. PMID: 18520763.
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    37. Perin L, Giuliani S, Sedrakyan S, DA Sacco S, De Filippo RE. Stem cell and regenerative science applications in the development of bioengineering of renal tissue. Pediatr Res. 2008 May; 63(5):467-71. PMID: 18427289.
      View in: PubMed
    38. Perin L, Sedrakyan S, Da Sacco S, De Filippo R. Characterization of human amniotic fluid stem cells and their pluripotential capability. Methods Cell Biol. 2008; 86:85-99. PMID: 18442645.
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    39. Perin L, Giuliani S, Jin D, Sedrakyan S, Carraro G, Habibian R, Warburton D, Atala A, De Filippo RE. Renal differentiation of amniotic fluid stem cells. Cell Prolif. 2007 Dec; 40(6):936-48. PMID: 18021180.
      View in: PubMed
    40. Giuliani S, Perin L, Sedrakyan S, Kokorowski P, Jin D, De Filippo R. Ex vivo whole embryonic kidney culture: a novel method for research in development, regeneration and transplantation. J Urol. 2008 Jan; 179(1):365-70. PMID: 18006007.
      View in: PubMed
    41. De Coppi P, Bartsch G, Siddiqui MM, Xu T, Santos CC, Perin L, Mostoslavsky G, Serre AC, Snyder EY, Yoo JJ, Furth ME, Soker S, Atala A. Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol. 2007 Jan; 25(1):100-6. PMID: 17206138.
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    42. Sedrakyan S, Zhou ZY, Perin L, Leach K, Mooney D, Kim TH. Tissue engineering of a small hand phalanx with a porously casted polylactic acid-polyglycolic acid copolymer. Tissue Eng. 2006 Sep; 12(9):2675-83. PMID: 16995801.
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    43. Bartsch G, Yoo JJ, De Coppi P, Siddiqui MM, Schuch G, Pohl HG, Fuhr J, Perin L, Soker S, Atala A. Propagation, expansion, and multilineage differentiation of human somatic stem cells from dermal progenitors. Stem Cells Dev. 2005 Jun; 14(3):337-48. PMID: 15969629.
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    44. Marzaro M, Conconi MT, Perin L, Giuliani S, Gamba P, De Coppi P, Perrino GP, Parnigotto PP, Nussdorfer GG. Autologous satellite cell seeding improves in vivo biocompatibility of homologous muscle acellular matrix implants. Int J Mol Med. 2002 Aug; 10(2):177-82. PMID: 12119555.
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