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James Amatruda, MD, PhD

Title(s)Professor of Pediatrics
AddressChildrens Hospital Los Angeles
Health Sciences Campus
Los Angeles CA 90027
Phone+1 323 361 9842
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    Collapse Biography 
    Collapse Education and Training
    Harvard University, Cambridge, MAA.B.05/1986Biochemical Sciences
    Washington University, St. Louis, MOM.D.05/1993Medicine
    Washington University, St. Louis, MOPh.D.05/1993Cell Biology
    Brigham and Women's Hospital, Boston, MA06/1996Internal Medicine
    Dana-Farber/Partners Cancer Care, Boston, MA06/1999Medical Oncology

    Collapse Overview 
    Collapse Overview
    James F. Amatruda, MD, PhD is Endowed Chair of Sarcoma Research in the Children’s Center for Cancer and Blood Diseases and the Division of Hematology, Oncology and Blood and Marrow Transplantation at Children’s Hospital Los Angeles; and Professor of Pediatrics and Medicine at the Keck School of Medicine of the University of Southern California. He received his Bachelor’s degree in Biochemical Sciences from Harvard University and his MD,PhD from Washington University School of Medicine. He did internship and residency training in Internal Medicine at the Brigham and Women’s Hospital in Boston, MA, followed by fellowship training in Medical Oncology at Dana-Farber/Partners Cancer Care in Boston, MA. He was a Postdoctoral Fellow in the laboratory of Dr. Leonard Zon at Boston Children’s Hospital, Harvard Medical School. From 2005-2019, Dr. Amatruda was on the faculty of UT Southwestern Medical Center in Dallas, TX.

    Dr. Amatruda is a physician-scientist with a primary research and clinical focus on solid tumors of childhood including sarcomas, germ cell tumors and Wilms tumor. His lab has developed zebrafish models of genetic subtypes of pediatric solid tumors to better define their biology and to use that knowledge to identify and validate novel approaches for improved therapies. He has had long-standing leadership positions in the Children’s Oncology Group; serving as Chair for the Germ Cell Tumor Biology Committee and the Rare Tumors Biology Committee. He also serves as a member of the COG Solid Malignancies Integrated Translational Science Center Steering Committee, and on the Scientific Advisory Boards of the William Guy Forbeck Foundation, the Osteosarcoma Institute, the Pablove Foundation, Curing Kids Cancer and the 1 Million 4 Anna Foundation.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Germ Cell Tumor Cell Culture Techniques. Methods Mol Biol. 2021; 2195:65-76. Lafin JT, Amatruda JF, Bagrodia A. PMID: 32852757.
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    2. Developing and Using a Data Commons for Understanding the Molecular Characteristics of Germ Cell Tumors. Methods Mol Biol. 2021; 2195:263-275. Ci B, Lin SY, Yao B, Luo D, Xu L, Krailo M, Murray MJ, Amatruda JF, Frazier AL, Xie Y. PMID: 32852769.
      View in: PubMed   Mentions:    Fields:    
    3. Real-World Application of Pre-orchiectomy miR-371a-3p Test in Testicular Germ Cell Tumor Management. J Urol. 2020 Aug 28; 101097JU0000000000001337. Badia RR, Abe D, Wong D, Singla N, Savelyeva A, Chertack N, Woldu SL, Lotan Y, Mauck R, Ouyang D, Meng X, Lewis CM, Majmudar K, Jia L, Kapur P, Xu L, Frazier AL, Margulis V, Strand DW, Coleman N, Murray MJ, Amatruda JF, Lafin JT, Bagrodia A. PMID: 32856980.
      View in: PubMed   Mentions:    Fields:    
    4. Development of a Data Model and Data Commons for Germ Cell Tumors. JCO Clin Cancer Inform. 2020 Jun; 4:555-566. Ci B, Yang DM, Krailo M, Xia C, Yao B, Luo D, Zhou Q, Xiao G, Xu L, Skapek SX, Murray MM, Amatruda JF, Klosterkemper L, Shaikh F, Faure-Conter C, Fresneau B, Volchenboum SL, Stoneham S, Lopes LF, Nicholson J, Frazier AL, Xie Y. PMID: 32568554.
      View in: PubMed   Mentions:    Fields:    
    5. Birth Characteristics and Risk of Early-Onset Synovial Sarcoma. Cancer Epidemiol Biomarkers Prev. 2020 Jun; 29(6):1162-1167. Wiemels JL, Wang R, Feng Q, Clark CJ, Amatruda JF, Rubin E, Yee AC, Morimoto LM, Metayer C, Ma X. PMID: 32245786.
      View in: PubMed   Mentions:    Fields:    
    6. GCNA Preserves Genome Integrity and Fertility Across Species. Dev Cell. 2020 01 06; 52(1):38-52.e10. Bhargava V, Goldstein CD, Russell L, Xu L, Ahmed M, Li W, Casey A, Servage K, Kollipara R, Picciarelli Z, Kittler R, Yatsenko A, Carmell M, Orth K, Amatruda JF, Yanowitz JL, Buszczak M. PMID: 31839537.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. Serum MicroRNA-371a-3p Levels Predict Viable Germ Cell Tumor in Chemotherapy-naïve Patients Undergoing Retroperitoneal Lymph Node Dissection. Eur Urol. 2020 02; 77(2):290-292. Lafin JT, Singla N, Woldu SL, Lotan Y, Lewis CM, Majmudar K, Savelyeva A, Kapur P, Margulis V, Strand DW, Murray MJ, Amatruda JF, Bagrodia A. PMID: 31699528.
      View in: PubMed   Mentions: 1     Fields:    
    8. Genetics of testicular germ cell tumors. Curr Opin Urol. 2019 07; 29(4):344-349. Singla N, Lafin JT, Ghandour RA, Kaffenberger S, Amatruda JF, Bagrodia A. PMID: 31045925.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. Detection of Relapse by Tumor Markers Versus Imaging in Children and Adolescents With Nongerminomatous Malignant Germ Cell Tumors: A Report From the Children's Oncology Group. J Clin Oncol. 2019 02 10; 37(5):396-402. Fonseca A, Xia C, Lorenzo AJ, Krailo M, Olson TA, Pashankar F, Malogolowkin MH, Amatruda JF, Billmire DF, Rodriguez-Galindo C, Frazier AL, Shaikh F. PMID: 30576269.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. pouC Regulates Expression of bmp4 During Atrioventricular Canal Formation in Zebrafish. Dev Dyn. 2019 02; 248(2):173-188. Bhakta M, Padanad MS, Harris JP, Lubczyk C, Amatruda JF, Munshi NV. PMID: 30444277.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    11. Differences in DNA methylation profiles by histologic subtype of paediatric germ cell tumours: a report from the Children's Oncology Group. Br J Cancer. 2018 10; 119(7):864-872. Williams LA, Mills L, Hooten AJ, Langer E, Roesler M, Frazier AL, Krailo M, Nelson HH, Bestrashniy J, Amatruda JF, Poynter JN. PMID: 30287918.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    12. Klinefelter syndrome in males with germ cell tumors: A report from the Children's Oncology Group. Cancer. 2018 10 01; 124(19):3900-3908. Williams LA, Pankratz N, Lane J, Krailo M, Roesler M, Richardson M, Frazier AL, Amatruda JF, Poynter JN. PMID: 30291793.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    13. Mutations in microRNA processing genes in Wilms tumors derepress the IGF2 regulator PLAG1. Genes Dev. 2018 08 01; 32(15-16):996-1007. Chen KS, Stroup EK, Budhipramono A, Rakheja D, Nichols-Vinueza D, Xu L, Stuart SH, Shukla AA, Fraire C, Mendell JT, Amatruda JF. PMID: 30026293.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    14. Integrative Bayesian Analysis Identifies Rhabdomyosarcoma Disease Genes. Cell Rep. 2018 07 03; 24(1):238-251. Xu L, Zheng Y, Liu J, Rakheja D, Singleterry S, Laetsch TW, Shern JF, Khan J, Triche TJ, Hawkins DS, Amatruda JF, Skapek SX. PMID: 29972784.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    15. Practice Patterns and Impact of Postchemotherapy Retroperitoneal Lymph Node Dissection on Testicular Cancer Outcomes. Eur Urol Oncol. 2018 08; 1(3):242-251. Woldu SL, Moore JA, Ci B, Freifeld Y, Clinton TN, Aydin AM, Singla N, Laura-Maria K, Hutchinson RC, Amatruda JF, Sagalowsky A, Lotan Y, Arriaga Y, Margulis V, Xie Y, Bagrodia A. PMID: 31058267.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Is carboplatin-based chemotherapy as effective as cisplatin-based chemotherapy in the treatment of advanced-stage dysgerminoma in children, adolescents and young adults? Gynecol Oncol. 2018 08; 150(2):253-260. Shah R, Xia C, Krailo M, Amatruda JF, Arul SG, Billmire DF, Brady WE, Covens A, Gershenson DM, Hale JP, Hurteau J, Murray MJ, Nicholson JC, Olson TA, Pashankar F, Rodriguez-Galindo C, Shaikh F, Stark D, Frazier AL, Stoneham S. PMID: 29884437.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis. Elife. 2018 06 05; 7. Kendall GC, Watson S, Xu L, LaVigne CA, Murchison W, Rakheja D, Skapek SX, Tirode F, Delattre O, Amatruda JF. PMID: 29869612.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    18. Comparison of carboplatin versus cisplatin in the treatment of paediatric extracranial malignant germ cell tumours: A report of the Malignant Germ Cell International Consortium. Eur J Cancer. 2018 07; 98:30-37. Frazier AL, Stoneham S, Rodriguez-Galindo C, Dang H, Xia C, Olson TA, Murray MJ, Amatruda JF, Shaikh F, Pashankar F, Billmire D, Krailo M, Stark D, Brougham MFH, Nicholson JC, Hale JP. PMID: 29859339.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. EGF Receptor and mTORC1 Are Novel Therapeutic Targets in Nonseminomatous Germ Cell Tumors. Mol Cancer Ther. 2018 05; 17(5):1079-1089. Chen KS, Fustino NJ, Shukla AA, Stroup EK, Budhipramono A, Ateek C, Stuart SH, Yamaguchi K, Kapur P, Frazier AL, Lum L, Looijenga LHJ, Laetsch TW, Rakheja D, Amatruda JF. PMID: 29483210.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    20. Pediatric Germ Cell Tumors: A Developmental Perspective. Adv Urol. 2018; 2018:9059382. Pierce JL, Frazier AL, Amatruda JF. PMID: 29515628.
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    21. Adolescents and Young Adults With a "Rare" Cancer: Getting Past Semantics to Optimal Care for Patients With Germ Cell Tumors. Oncologist. 2018 02; 23(2):272. Stoneham SJ, Hale JP, Rodriguez-Galindo C, Dang H, Olson T, Murray M, Amatruda JF, Thornton C, Arul GS, Billmire D, Krailo M, Stark D, Covens A, Hurteau J, Stenning S, Nicholson JC, Gershenson D, Frazier AL. PMID: 29449513.
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    22. Gonadal dysgenesis is associated with worse outcomes in patients with ovarian nondysgerminomatous tumors: A report of the Children's Oncology Group AGCT 0132 study. Pediatr Blood Cancer. 2018 04; 65(4). Dicken BJ, Billmire DF, Krailo M, Xia C, Shaikh F, Cullen JW, Olson TA, Pashankar F, Malogolowkin MH, Amatruda JF, Rescorla FJ, Egler RA, Ross JH, Rodriguez-Galindo C, Frazier AL. PMID: 29286555.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    23. Differences at Presentation and Treatment of Testicular Cancer in Hispanic Men: Institutional and National Hospital-based Analyses. Urology. 2018 02; 112:103-111. Woldu SL, Aydin AM, Rao AV, Hutchinson RC, Singla N, Clinton TN, Krabbe LM, Passoni NM, Raj GV, Miller DS, Amatruda JF, Sagalowsky AI, Lotan Y, Arriaga Y, Margulis V, Bagrodia A. PMID: 29079210.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    24. Family history of cancer in children and adolescents with germ cell tumours: a report from the Children's Oncology Group. Br J Cancer. 2018 01; 118(1):121-126. Poynter JN, Richardson M, Roesler M, Krailo M, Amatruda JF, Frazier AL. PMID: 29065103.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    25. Retrotransposons Mimic Germ Plasm Determinants to Promote Transgenerational Inheritance. Curr Biol. 2017 Oct 09; 27(19):3010-3016.e3. Tiwari B, Kurtz P, Jones AE, Wylie A, Amatruda JF, Boggupalli DP, Gonsalvez GB, Abrams JM. PMID: 28966088.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    26. Variants in BAK1, SPRY4, and GAB2 are associated with pediatric germ cell tumors: A report from the children's oncology group. Genes Chromosomes Cancer. 2017 07; 56(7):548-558. Marcotte EL, Pankratz N, Amatruda JF, Frazier AL, Krailo M, Davies S, Starr JR, Lau CC, Roesler M, Langer E, Hallstrom C, Hooten AJ, Poynter JN. PMID: 28295819.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    27. Reduced and Compressed Cisplatin-Based Chemotherapy in Children and Adolescents With Intermediate-Risk Extracranial Malignant Germ Cell Tumors: A Report From the Children's Oncology Group. J Clin Oncol. 2017 Apr 10; 35(11):1203-1210. Shaikh F, Cullen JW, Olson TA, Pashankar F, Malogolowkin MH, Amatruda JF, Villaluna D, Krailo M, Billmire DF, Rescorla FJ, Egler RA, Dicken BJ, Ross JH, Schlatter M, Rodriguez-Galindo C, Frazier AL. PMID: 28240974.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    28. Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):1649-1654. Moon J, Zhou H, Zhang LS, Tan W, Liu Y, Zhang S, Morlock LK, Bao X, Palecek SP, Feng JQ, Williams NS, Amatruda JF, Olson EN, Bassel-Duby R, Lum L. PMID: 28143939.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    29. Testicular germ cell tumor genomics. Curr Opin Urol. 2017 01; 27(1):41-47. Woldu SL, Amatruda JF, Bagrodia A. PMID: 27584029.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    30. Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation. Nat Med. 2017 01; 23(1):79-90. Lu Z, Xie J, Wu G, Shen J, Collins R, Chen W, Kang X, Luo M, Zou Y, Huang LJ, Amatruda JF, Slone T, Winick N, Scherer PE, Zhang CC. PMID: 27941793.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    31. Genetic inhibition of autophagy promotes p53 loss-of-heterozygosity and tumorigenesis. Oncotarget. 2016 10 18; 7(42):67919-67933. Lee E, Wei Y, Zou Z, Tucker K, Rakheja D, Levine B, Amatruda JF. PMID: 27655644.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    32. Risk of second gonadal cancers in women and children with germ cell tumors. Cancer. 2016 07 01; 122(13):2076-82. Liao ZW, Rodrigues MC, Poynter JN, Amatruda JF, Rodriguez-Galindo C, Frazier AL. PMID: 27152727.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    33. Paediatric extracranial germ-cell tumours. Lancet Oncol. 2016 04; 17(4):e149-e162. Shaikh F, Murray MJ, Amatruda JF, Coleman N, Nicholson JC, Hale JP, Pashankar F, Stoneham SJ, Poynter JN, Olson TA, Billmire DF, Stark D, Rodriguez-Galindo C, Frazier AL. PMID: 27300675.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    34. Zebrafish as a Model for the Study of Solid Malignancies. Methods Mol Biol. 2016; 1451:121-42. Kendall GC, Amatruda JF. PMID: 27464805.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    35. Zebrafish Germ Cell Tumors. Adv Exp Med Biol. 2016; 916:479-94. Sanchez A, Amatruda JF. PMID: 27165367.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    36. Biochemical Analysis of Tankyrase Activity in Zebrafish In Vitro and In Vivo. Methods Mol Biol. 2016; 1481:95-100. Moon J, Amatruda JF. PMID: 27590155.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    37. p53 genes function to restrain mobile elements. Genes Dev. 2016 Jan 01; 30(1):64-77. Wylie A, Jones AE, D'Brot A, Lu WJ, Kurtz P, Moran JV, Rakheja D, Chen KS, Hammer RE, Comerford SA, Amatruda JF, Abrams JM. PMID: 26701264.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    38. Is adjuvant chemotherapy indicated in ovarian immature teratomas? A combined data analysis from the Malignant Germ Cell Tumor International Collaborative. Cancer. 2016 Jan 15; 122(2):230-7. Pashankar F, Hale JP, Dang H, Krailo M, Brady WE, Rodriguez-Galindo C, Nicholson JC, Murray MJ, Bilmire DF, Stoneham S, Arul GS, Olson TA, Stark D, Shaikh F, Amatruda JF, Covens A, Gershenson DM, Frazier AL. PMID: 26485622.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    39. Pediatric and Adolescent Extracranial Germ Cell Tumors: The Road to Collaboration. J Clin Oncol. 2015 Sep 20; 33(27):3018-28. Olson TA, Murray MJ, Rodriguez-Galindo C, Nicholson JC, Billmire DF, Krailo MD, Dang HM, Amatruda JF, Thornton CM, Arul GS, Stoneham SJ, Pashankar F, Stark D, Shaikh F, Gershenson DM, Covens A, Hurteau J, Stenning SP, Feldman DR, Grimison PS, Huddart RA, Sweeney C, Powles T, Lopes LF, dos Santos Agular S, Chinnaswamy G, Khaleel S, Abouelnaga S, Hale JP, Frazier AL. PMID: 26304902.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    40. Surveillance after initial surgery for Stage I pediatric and adolescent boys with malignant testicular germ cell tumors: Report from the Children's Oncology Group. J Pediatr Surg. 2015 Jun; 50(6):1000-3. Rescorla FJ, Ross JH, Billmire DF, Dicken BJ, Villaluna D, Davis MM, Krailo M, Cullen JW, Olson TA, Egler RA, Amatruda JF, Rodrigues-Galindo C, Frazier AL. PMID: 25812445.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    41. Revised risk classification for pediatric extracranial germ cell tumors based on 25 years of clinical trial data from the United Kingdom and United States. J Clin Oncol. 2015 Jan 10; 33(2):195-201. Frazier AL, Hale JP, Rodriguez-Galindo C, Dang H, Olson T, Murray MJ, Amatruda JF, Thornton C, Arul GS, Billmire D, Shaikh F, Pashankar F, Stoneham S, Krailo M, Nicholson JC. PMID: 25452439.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    42. Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours. Nat Commun. 2014 Sep 05; 2:4802. Rakheja D, Chen KS, Liu Y, Shukla AA, Schmid V, Chang TC, Khokhar S, Wickiser JE, Karandikar NJ, Malter JS, Mendell JT, Amatruda JF. PMID: 25190313.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    43. Adolescents and young adults with a "rare" cancer: getting past semantics to optimal care for patients with germ cell tumors. Oncologist. 2014 Jul; 19(7):689-92. Stoneham SJ, Hale JP, Rodriguez-Galindo C, Dang H, Olson T, Murray M, Amatruda JF, Thornton C, Arul GS, Billmire D, Krailo M, Stark D, Covens A, Hurteau J, Stenning S, Nicholson JC, Gershenson D, Frazier AL. PMID: 24899644.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    44. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell. 2014 Apr 24; 157(3):565-79. Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Aroumougame A, Shah AM, Szweda LI, Sadek HA. PMID: 24766806.
      View in: PubMed   Mentions: 152     Fields:    Translation:AnimalsCells
    45. Autophagy is essential for cardiac morphogenesis during vertebrate development. Autophagy. 2014 Apr; 10(4):572-87. Lee E, Koo Y, Ng A, Wei Y, Luby-Phelps K, Juraszek A, Xavier RJ, Cleaver O, Levine B, Amatruda JF. PMID: 24441423.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    46. DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors. BMC Cancer. 2013 Jun 27; 13:313. Amatruda JF, Ross JA, Christensen B, Fustino NJ, Chen KS, Hooten AJ, Nelson H, Kuriger JK, Rakheja D, Frazier AL, Poynter JN. PMID: 23806198.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    47. A big catch for germ cell tumour research. PLoS Genet. 2013 Apr; 9(4):e1003481. Chen KS, Amatruda JF. PMID: 23593043.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    48. The development of highly potent inhibitors for porcupine. J Med Chem. 2013 Mar 28; 56(6):2700-4. Wang X, Moon J, Dodge ME, Pan X, Zhang L, Hanson JM, Tuladhar R, Ma Z, Shi H, Williams NS, Amatruda JF, Carroll TJ, Lum L, Chen C. PMID: 23477365.
      View in: PubMed   Mentions: 20     Fields:    
    49. Children's Oncology Group's 2013 blueprint for research: rare tumors. Pediatr Blood Cancer. 2013 Jun; 60(6):1016-21. Rodriguez-Galindo C, Krailo M, Frazier L, Chintagumpala M, Amatruda J, Katzenstein H, Malogolowkin M, Spector L, Pashankar F, Meyers R, Tomlinson G. PMID: 23255219.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    50. C/EBP transcription factors mediate epicardial activation during heart development and injury. Science. 2012 Dec 21; 338(6114):1599-603. Huang GN, Thatcher JE, McAnally J, Kong Y, Qi X, Tan W, DiMaio JM, Amatruda JF, Gerard RD, Hill JA, Bassel-Duby R, Olson EN. PMID: 23160954.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    51. Multiple isoforms of CDC25 oppose ATM activity to maintain cell proliferation during vertebrate development. Mol Cancer Res. 2012 Nov; 10(11):1451-61. Verduzco D, Dovey JS, Shukla AA, Kodym E, Skaug BA, Amatruda JF. PMID: 22986406.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    52. Fetal and neonatal germ cell tumors. Semin Fetal Neonatal Med. 2012 Aug; 17(4):222-230. Frazier AL, Weldon C, Amatruda J. PMID: 22647545.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    53. Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine. J Biol Chem. 2012 Jun 29; 287(27):23246-54. Dodge ME, Moon J, Tuladhar R, Lu J, Jacob LS, Zhang LS, Shi H, Wang X, Moro E, Mongera A, Argenton F, Karner CM, Carroll TJ, Chen C, Amatruda JF, Lum L. PMID: 22593577.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    54. Studying synthetic lethal interactions in the zebrafish system: insight into disease genes and mechanisms. Dis Model Mech. 2012 Jan; 5(1):33-7. Hajeri VA, Amatruda JF. PMID: 22107871.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    55. A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis. Dis Model Mech. 2012 Jan; 5(1):95-106. Leacock SW, Basse AN, Chandler GL, Kirk AM, Rakheja D, Amatruda JF. PMID: 21979944.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    56. Mutation in the type IB bone morphogenetic protein receptor Alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish. Proc Natl Acad Sci U S A. 2011 Aug 09; 108(32):13153-8. Neumann JC, Chandler GL, Damoulis VA, Fustino NJ, Lillard K, Looijenga L, Margraf L, Rakheja D, Amatruda JF. PMID: 21775673.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    57. High-resolution array CGH identifies common mechanisms that drive embryonal rhabdomyosarcoma pathogenesis. Genes Chromosomes Cancer. 2011 Jun; 50(6):397-408. Paulson V, Chandler G, Rakheja D, Galindo RL, Wilson K, Amatruda JF, Cameron S. PMID: 21412928.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    58. Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling. Sci Signal. 2011 Jan 25; 4(157):ra4. Jacob LS, Wu X, Dodge ME, Fan CW, Kulak O, Chen B, Tang W, Wang B, Amatruda JF, Lum L. PMID: 21266715.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    59. Analysis of cell proliferation, senescence, and cell death in zebrafish embryos. Methods Cell Biol. 2011; 101:19-38. Verduzco D, Amatruda JF. PMID: 21550438.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    60. Zebrafish models of germ cell tumor. Methods Cell Biol. 2011; 105:3-24. Neumann JC, Lillard K, Damoulis V, Amatruda JF. PMID: 21951524.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    61. Breast cancer between faith and medicine: the Peres Maldonado ex-voto. Med Humanit. 2010 Dec; 36(2):112-4. Pon L, Amatruda JF. PMID: 21393294.
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    63. Effect of vascular cadherin knockdown on zebrafish vasculature during development. PLoS One. 2010 Jan 20; 5(1):e8807. Mitchell IC, Brown TS, Terada LS, Amatruda JF, Nwariaku FE. PMID: 20098718.
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    64. Identification of a heritable model of testicular germ cell tumor in the zebrafish. Zebrafish. 2009 Dec; 6(4):319-27. Neumann JC, Dovey JS, Chandler GL, Carbajal L, Amatruda JF. PMID: 20047465.
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    65. p53 ancestry: gazing through an evolutionary lens. Nat Rev Cancer. 2009 10; 9(10):758-62. Lu WJ, Amatruda JF, Abrams JM. PMID: 19776745.
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    66. Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg Med Chem Lett. 2009 Jul 15; 19(14):3825-7. Lu J, Ma Z, Hsieh JC, Fan CW, Chen B, Longgood JC, Williams NS, Amatruda JF, Lum L, Chen C. PMID: 19410457.
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    67. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol. 2009 Feb; 5(2):100-7. Chen B, Dodge ME, Tang W, Lu J, Ma Z, Fan CW, Wei S, Hao W, Kilgore J, Williams NS, Roth MG, Amatruda JF, Chen C, Lum L. PMID: 19125156.
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    68. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell. 2008 May 30; 133(5):864-77. Sidi S, Sanda T, Kennedy RD, Hagen AT, Jette CA, Hoffmans R, Pascual J, Imamura S, Kishi S, Amatruda JF, Kanki JP, Green DR, D'Andrea AA, Look AT. PMID: 18510930.
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    69. Genetic models of cancer in zebrafish. Int Rev Cell Mol Biol. 2008; 271:1-34. Amatruda JF, Patton EE. PMID: 19081540.
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