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James Amatruda

Title(s)Visiting Professor of Pediatrics
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Singla N, Lafin JT, Ghandour RA, Kaffenberger S, Amatruda JF, Bagrodia A. Genetics of testicular germ cell tumors. Curr Opin Urol. 2019 Jul; 29(4):344-349. PMID: 31045925.
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    2. Fonseca A, Xia C, Lorenzo AJ, Krailo M, Olson TA, Pashankar F, Malogolowkin MH, Amatruda JF, Billmire DF, Rodriguez-Galindo C, Frazier AL, Shaikh F. Detection of Relapse by Tumor Markers Versus Imaging in Children and Adolescents With Nongerminomatous Malignant Germ Cell Tumors: A Report From the Children's Oncology Group. J Clin Oncol. 2019 Feb 10; 37(5):396-402. PMID: 30576269.
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    3. Bhakta M, Padanad MS, Harris JP, Lubczyk C, Amatruda JF, Munshi NV. pouC Regulates Expression of bmp4 During Atrioventricular Canal Formation in Zebrafish. Dev Dyn. 2019 02; 248(2):173-188. PMID: 30444277.
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    4. Williams LA, Mills L, Hooten AJ, Langer E, Roesler M, Frazier AL, Krailo M, Nelson HH, Bestrashniy J, Amatruda JF, Poynter JN. Differences in DNA methylation profiles by histologic subtype of paediatric germ cell tumours: a report from the Children's Oncology Group. Br J Cancer. 2018 Oct; 119(7):864-872. PMID: 30287918.
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    5. Williams LA, Pankratz N, Lane J, Krailo M, Roesler M, Richardson M, Frazier AL, Amatruda JF, Poynter JN. Klinefelter syndrome in males with germ cell tumors: A report from the Children's Oncology Group. Cancer. 2018 Oct 01; 124(19):3900-3908. PMID: 30291793.
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    6. Chen KS, Stroup EK, Budhipramono A, Rakheja D, Nichols-Vinueza D, Xu L, Stuart SH, Shukla AA, Fraire C, Mendell JT, Amatruda JF. Mutations in microRNA processing genes in Wilms tumors derepress the IGF2 regulator PLAG1. Genes Dev. 2018 08 01; 32(15-16):996-1007. PMID: 30026293.
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    7. Xu L, Zheng Y, Liu J, Rakheja D, Singleterry S, Laetsch TW, Shern JF, Khan J, Triche TJ, Hawkins DS, Amatruda JF, Skapek SX. Integrative Bayesian Analysis Identifies Rhabdomyosarcoma Disease Genes. Cell Rep. 2018 Jul 03; 24(1):238-251. PMID: 29972784.
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    8. Woldu SL, Moore JA, Ci B, Freifeld Y, Clinton TN, Aydin AM, Singla N, Laura-Maria K, Hutchinson RC, Amatruda JF, Sagalowsky A, Lotan Y, Arriaga Y, Margulis V, Xie Y, Bagrodia A. Practice Patterns and Impact of Postchemotherapy Retroperitoneal Lymph Node Dissection on Testicular Cancer Outcomes. Eur Urol Oncol. 2018 Aug; 1(3):242-251. PMID: 31058267.
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    9. Kendall GC, Watson S, Xu L, LaVigne CA, Murchison W, Rakheja D, Skapek SX, Tirode F, Delattre O, Amatruda JF. PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis. Elife. 2018 06 05; 7. PMID: 29869612.
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    10. Shah R, Xia C, Krailo M, Amatruda JF, Arul SG, Billmire DF, Brady WE, Covens A, Gershenson DM, Hale JP, Hurteau J, Murray MJ, Nicholson JC, Olson TA, Pashankar F, Rodriguez-Galindo C, Shaikh F, Stark D, Frazier AL, Stoneham S. Is carboplatin-based chemotherapy as effective as cisplatin-based chemotherapy in the treatment of advanced-stage dysgerminoma in children, adolescents and young adults? Gynecol Oncol. 2018 08; 150(2):253-260. PMID: 29884437.
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    11. Frazier AL, Stoneham S, Rodriguez-Galindo C, Dang H, Xia C, Olson TA, Murray MJ, Amatruda JF, Shaikh F, Pashankar F, Billmire D, Krailo M, Stark D, Brougham MFH, Nicholson JC, Hale JP. Comparison of carboplatin versus cisplatin in the treatment of paediatric extracranial malignant germ cell tumours: A report of the Malignant Germ Cell International Consortium. Eur J Cancer. 2018 07; 98:30-37. PMID: 29859339.
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    12. Chen KS, Fustino NJ, Shukla AA, Stroup EK, Budhipramono A, Ateek C, Stuart SH, Yamaguchi K, Kapur P, Frazier AL, Lum L, Looijenga LHJ, Laetsch TW, Rakheja D, Amatruda JF. EGF Receptor and mTORC1 Are Novel Therapeutic Targets in Nonseminomatous Germ Cell Tumors. Mol Cancer Ther. 2018 05; 17(5):1079-1089. PMID: 29483210.
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    13. Pierce JL, Frazier AL, Amatruda JF. Pediatric Germ Cell Tumors: A Developmental Perspective. Adv Urol. 2018; 2018:9059382. PMID: 29515628.
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    14. Stoneham SJ, Hale JP, Rodriguez-Galindo C, Dang H, Olson T, Murray M, Amatruda JF, Thornton C, Arul GS, Billmire D, Krailo M, Stark D, Covens A, Hurteau J, Stenning S, Nicholson JC, Gershenson D, Frazier AL. Adolescents and Young Adults With a "Rare" Cancer: Getting Past Semantics to Optimal Care for Patients With Germ Cell Tumors. Oncologist. 2018 Feb; 23(2):272. PMID: 29449513.
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    15. Dicken BJ, Billmire DF, Krailo M, Xia C, Shaikh F, Cullen JW, Olson TA, Pashankar F, Malogolowkin MH, Amatruda JF, Rescorla FJ, Egler RA, Ross JH, Rodriguez-Galindo C, Frazier AL. Gonadal dysgenesis is associated with worse outcomes in patients with ovarian nondysgerminomatous tumors: A report of the Children's Oncology Group AGCT 0132 study. Pediatr Blood Cancer. 2018 Apr; 65(4). PMID: 29286555.
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    16. Woldu SL, Aydin AM, Rao AV, Hutchinson RC, Singla N, Clinton TN, Krabbe LM, Passoni NM, Raj GV, Miller DS, Amatruda JF, Sagalowsky AI, Lotan Y, Arriaga Y, Margulis V, Bagrodia A. Differences at Presentation and Treatment of Testicular Cancer in Hispanic Men: Institutional and National Hospital-based Analyses. Urology. 2018 02; 112:103-111. PMID: 29079210.
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    17. Poynter JN, Richardson M, Roesler M, Krailo M, Amatruda JF, Frazier AL. Family history of cancer in children and adolescents with germ cell tumours: a report from the Children's Oncology Group. Br J Cancer. 2018 01; 118(1):121-126. PMID: 29065103.
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    18. Tiwari B, Kurtz P, Jones AE, Wylie A, Amatruda JF, Boggupalli DP, Gonsalvez GB, Abrams JM. Retrotransposons Mimic Germ Plasm Determinants to Promote Transgenerational Inheritance. Curr Biol. 2017 Oct 09; 27(19):3010-3016.e3. PMID: 28966088.
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    19. Marcotte EL, Pankratz N, Amatruda JF, Frazier AL, Krailo M, Davies S, Starr JR, Lau CC, Roesler M, Langer E, Hallstrom C, Hooten AJ, Poynter JN. Variants in BAK1, SPRY4, and GAB2 are associated with pediatric germ cell tumors: A report from the children's oncology group. Genes Chromosomes Cancer. 2017 07; 56(7):548-558. PMID: 28295819.
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    20. Shaikh F, Cullen JW, Olson TA, Pashankar F, Malogolowkin MH, Amatruda JF, Villaluna D, Krailo M, Billmire DF, Rescorla FJ, Egler RA, Dicken BJ, Ross JH, Schlatter M, Rodriguez-Galindo C, Frazier AL. Reduced and Compressed Cisplatin-Based Chemotherapy in Children and Adolescents With Intermediate-Risk Extracranial Malignant Germ Cell Tumors: A Report From the Children's Oncology Group. J Clin Oncol. 2017 Apr 10; 35(11):1203-1210. PMID: 28240974.
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    21. Moon J, Zhou H, Zhang LS, Tan W, Liu Y, Zhang S, Morlock LK, Bao X, Palecek SP, Feng JQ, Williams NS, Amatruda JF, Olson EN, Bassel-Duby R, Lum L. Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):1649-1654. PMID: 28143939.
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    22. Woldu SL, Amatruda JF, Bagrodia A. Testicular germ cell tumor genomics. Curr Opin Urol. 2017 01; 27(1):41-47. PMID: 27584029.
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    23. Lu Z, Xie J, Wu G, Shen J, Collins R, Chen W, Kang X, Luo M, Zou Y, Huang LJ, Amatruda JF, Slone T, Winick N, Scherer PE, Zhang CC. Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation. Nat Med. 2017 01; 23(1):79-90. PMID: 27941793.
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    24. Lee E, Wei Y, Zou Z, Tucker K, Rakheja D, Levine B, Amatruda JF. Genetic inhibition of autophagy promotes p53 loss-of-heterozygosity and tumorigenesis. Oncotarget. 2016 10 18; 7(42):67919-67933. PMID: 27655644.
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    25. Liao ZW, Rodrigues MC, Poynter JN, Amatruda JF, Rodriguez-Galindo C, Frazier AL. Risk of second gonadal cancers in women and children with germ cell tumors. Cancer. 2016 07 01; 122(13):2076-82. PMID: 27152727.
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    26. Shaikh F, Murray MJ, Amatruda JF, Coleman N, Nicholson JC, Hale JP, Pashankar F, Stoneham SJ, Poynter JN, Olson TA, Billmire DF, Stark D, Rodriguez-Galindo C, Frazier AL. Paediatric extracranial germ-cell tumours. Lancet Oncol. 2016 04; 17(4):e149-e162. PMID: 27300675.
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    27. Kendall GC, Amatruda JF. Zebrafish as a Model for the Study of Solid Malignancies. Methods Mol Biol. 2016; 1451:121-42. PMID: 27464805.
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    28. Sanchez A, Amatruda JF. Zebrafish Germ Cell Tumors. Adv Exp Med Biol. 2016; 916:479-94. PMID: 27165367.
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    29. Moon J, Amatruda JF. Biochemical Analysis of Tankyrase Activity in Zebrafish In Vitro and In Vivo. Methods Mol Biol. 2016; 1481:95-100. PMID: 27590155.
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    30. Wylie A, Jones AE, D'Brot A, Lu WJ, Kurtz P, Moran JV, Rakheja D, Chen KS, Hammer RE, Comerford SA, Amatruda JF, Abrams JM. p53 genes function to restrain mobile elements. Genes Dev. 2016 Jan 01; 30(1):64-77. PMID: 26701264.
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    31. Pashankar F, Hale JP, Dang H, Krailo M, Brady WE, Rodriguez-Galindo C, Nicholson JC, Murray MJ, Bilmire DF, Stoneham S, Arul GS, Olson TA, Stark D, Shaikh F, Amatruda JF, Covens A, Gershenson DM, Frazier AL. Is adjuvant chemotherapy indicated in ovarian immature teratomas? A combined data analysis from the Malignant Germ Cell Tumor International Collaborative. Cancer. 2016 Jan 15; 122(2):230-7. PMID: 26485622.
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    32. Olson TA, Murray MJ, Rodriguez-Galindo C, Nicholson JC, Billmire DF, Krailo MD, Dang HM, Amatruda JF, Thornton CM, Arul GS, Stoneham SJ, Pashankar F, Stark D, Shaikh F, Gershenson DM, Covens A, Hurteau J, Stenning SP, Feldman DR, Grimison PS, Huddart RA, Sweeney C, Powles T, Lopes LF, dos Santos Agular S, Chinnaswamy G, Khaleel S, Abouelnaga S, Hale JP, Frazier AL. Pediatric and Adolescent Extracranial Germ Cell Tumors: The Road to Collaboration. J Clin Oncol. 2015 Sep 20; 33(27):3018-28. PMID: 26304902.
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    33. Rescorla FJ, Ross JH, Billmire DF, Dicken BJ, Villaluna D, Davis MM, Krailo M, Cullen JW, Olson TA, Egler RA, Amatruda JF, Rodrigues-Galindo C, Frazier AL. Surveillance after initial surgery for Stage I pediatric and adolescent boys with malignant testicular germ cell tumors: Report from the Children's Oncology Group. J Pediatr Surg. 2015 Jun; 50(6):1000-3. PMID: 25812445.
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    34. Frazier AL, Hale JP, Rodriguez-Galindo C, Dang H, Olson T, Murray MJ, Amatruda JF, Thornton C, Arul GS, Billmire D, Shaikh F, Pashankar F, Stoneham S, Krailo M, Nicholson JC. Revised risk classification for pediatric extracranial germ cell tumors based on 25 years of clinical trial data from the United Kingdom and United States. J Clin Oncol. 2015 Jan 10; 33(2):195-201. PMID: 25452439.
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    35. Rakheja D, Chen KS, Liu Y, Shukla AA, Schmid V, Chang TC, Khokhar S, Wickiser JE, Karandikar NJ, Malter JS, Mendell JT, Amatruda JF. Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours. Nat Commun. 2014 Sep 05; 2:4802. PMID: 25190313.
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    36. Stoneham SJ, Hale JP, Rodriguez-Galindo C, Dang H, Olson T, Murray M, Amatruda JF, Thornton C, Arul GS, Billmire D, Krailo M, Stark D, Covens A, Hurteau J, Stenning S, Nicholson JC, Gershenson D, Frazier AL. Adolescents and young adults with a "rare" cancer: getting past semantics to optimal care for patients with germ cell tumors. Oncologist. 2014 Jul; 19(7):689-92. PMID: 24899644.
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    37. Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Aroumougame A, Shah AM, Szweda LI, Sadek HA. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell. 2014 Apr 24; 157(3):565-79. PMID: 24766806.
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    38. Lee E, Koo Y, Ng A, Wei Y, Luby-Phelps K, Juraszek A, Xavier RJ, Cleaver O, Levine B, Amatruda JF. Autophagy is essential for cardiac morphogenesis during vertebrate development. Autophagy. 2014 Apr; 10(4):572-87. PMID: 24441423.
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    39. Amatruda JF, Ross JA, Christensen B, Fustino NJ, Chen KS, Hooten AJ, Nelson H, Kuriger JK, Rakheja D, Frazier AL, Poynter JN. DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors. BMC Cancer. 2013 Jun 27; 13:313. PMID: 23806198.
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    40. Chen KS, Amatruda JF. A big catch for germ cell tumour research. PLoS Genet. 2013 Apr; 9(4):e1003481. PMID: 23593043.
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    41. Wang X, Moon J, Dodge ME, Pan X, Zhang L, Hanson JM, Tuladhar R, Ma Z, Shi H, Williams NS, Amatruda JF, Carroll TJ, Lum L, Chen C. The development of highly potent inhibitors for porcupine. J Med Chem. 2013 Mar 28; 56(6):2700-4. PMID: 23477365.
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    42. Rodriguez-Galindo C, Krailo M, Frazier L, Chintagumpala M, Amatruda J, Katzenstein H, Malogolowkin M, Spector L, Pashankar F, Meyers R, Tomlinson G. Children's Oncology Group's 2013 blueprint for research: rare tumors. Pediatr Blood Cancer. 2013 Jun; 60(6):1016-21. PMID: 23255219.
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    43. Huang GN, Thatcher JE, McAnally J, Kong Y, Qi X, Tan W, DiMaio JM, Amatruda JF, Gerard RD, Hill JA, Bassel-Duby R, Olson EN. C/EBP transcription factors mediate epicardial activation during heart development and injury. Science. 2012 Dec 21; 338(6114):1599-603. PMID: 23160954.
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    44. Verduzco D, Dovey JS, Shukla AA, Kodym E, Skaug BA, Amatruda JF. Multiple isoforms of CDC25 oppose ATM activity to maintain cell proliferation during vertebrate development. Mol Cancer Res. 2012 Nov; 10(11):1451-61. PMID: 22986406.
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    45. Frazier AL, Weldon C, Amatruda J. Fetal and neonatal germ cell tumors. Semin Fetal Neonatal Med. 2012 Aug; 17(4):222-230. PMID: 22647545.
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    46. Dodge ME, Moon J, Tuladhar R, Lu J, Jacob LS, Zhang LS, Shi H, Wang X, Moro E, Mongera A, Argenton F, Karner CM, Carroll TJ, Chen C, Amatruda JF, Lum L. Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine. J Biol Chem. 2012 Jun 29; 287(27):23246-54. PMID: 22593577.
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    47. Hajeri VA, Amatruda JF. Studying synthetic lethal interactions in the zebrafish system: insight into disease genes and mechanisms. Dis Model Mech. 2012 Jan; 5(1):33-7. PMID: 22107871.
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    48. Leacock SW, Basse AN, Chandler GL, Kirk AM, Rakheja D, Amatruda JF. A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis. Dis Model Mech. 2012 Jan; 5(1):95-106. PMID: 21979944.
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    49. Neumann JC, Chandler GL, Damoulis VA, Fustino NJ, Lillard K, Looijenga L, Margraf L, Rakheja D, Amatruda JF. Mutation in the type IB bone morphogenetic protein receptor Alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish. Proc Natl Acad Sci U S A. 2011 Aug 09; 108(32):13153-8. PMID: 21775673.
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    50. Paulson V, Chandler G, Rakheja D, Galindo RL, Wilson K, Amatruda JF, Cameron S. High-resolution array CGH identifies common mechanisms that drive embryonal rhabdomyosarcoma pathogenesis. Genes Chromosomes Cancer. 2011 Jun; 50(6):397-408. PMID: 21412928.
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    51. Jacob LS, Wu X, Dodge ME, Fan CW, Kulak O, Chen B, Tang W, Wang B, Amatruda JF, Lum L. Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling. Sci Signal. 2011 Jan 25; 4(157):ra4. PMID: 21266715.
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    52. Verduzco D, Amatruda JF. Analysis of cell proliferation, senescence, and cell death in zebrafish embryos. Methods Cell Biol. 2011; 101:19-38. PMID: 21550438.
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    53. Neumann JC, Lillard K, Damoulis V, Amatruda JF. Zebrafish models of germ cell tumor. Methods Cell Biol. 2011; 105:3-24. PMID: 21951524.
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    54. Pon L, Amatruda JF. Breast cancer between faith and medicine: the Peres Maldonado ex-voto. Med Humanit. 2010 Dec; 36(2):112-4. PMID: 21393294.
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    55. Poynter JN, Amatruda JF, Ross JA. Trends in incidence and survival of pediatric and adolescent patients with germ cell tumors in the United States, 1975 to 2006. Cancer. 2010 Oct 15; 116(20):4882-91. PMID: 20597129.
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    56. Mitchell IC, Brown TS, Terada LS, Amatruda JF, Nwariaku FE. Effect of vascular cadherin knockdown on zebrafish vasculature during development. PLoS One. 2010 Jan 20; 5(1):e8807. PMID: 20098718.
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    57. Neumann JC, Dovey JS, Chandler GL, Carbajal L, Amatruda JF. Identification of a heritable model of testicular germ cell tumor in the zebrafish. Zebrafish. 2009 Dec; 6(4):319-27. PMID: 20047465.
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    58. Lu WJ, Amatruda JF, Abrams JM. p53 ancestry: gazing through an evolutionary lens. Nat Rev Cancer. 2009 10; 9(10):758-62. PMID: 19776745.
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    59. Lu J, Ma Z, Hsieh JC, Fan CW, Chen B, Longgood JC, Williams NS, Amatruda JF, Lum L, Chen C. Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg Med Chem Lett. 2009 Jul 15; 19(14):3825-7. PMID: 19410457.
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    60. Chen B, Dodge ME, Tang W, Lu J, Ma Z, Fan CW, Wei S, Hao W, Kilgore J, Williams NS, Roth MG, Amatruda JF, Chen C, Lum L. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol. 2009 Feb; 5(2):100-7. PMID: 19125156.
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    61. Sidi S, Sanda T, Kennedy RD, Hagen AT, Jette CA, Hoffmans R, Pascual J, Imamura S, Kishi S, Amatruda JF, Kanki JP, Green DR, D'Andrea AA, Look AT. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell. 2008 May 30; 133(5):864-77. PMID: 18510930.
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    62. Amatruda JF, Patton EE. Genetic models of cancer in zebrafish. Int Rev Cell Mol Biol. 2008; 271:1-34. PMID: 19081540.
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    63. Shepard JL, Stern HM, Pfaff KL, Amatruda JF. Analysis of the cell cycle in zebrafish embryos. Methods Cell Biol. 2004; 76:109-25. PMID: 15602874.
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