James Amatruda, MD, PhD

Title(s)Professor of Pediatrics
SchoolKeck School of Medicine of Usc
AddressChildrens Hospital Los Angeles
Off Campus
Los Angeles CA 90027
Phone+1 323 361 9842
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    Collapse Biography 
    Collapse Education and Training
    Harvard University, Cambridge, MAA.B.05/1986Biochemical Sciences
    Washington University, St. Louis, MOM.D.05/1993Medicine
    Washington University, St. Louis, MOPh.D.05/1993Cell Biology
    Brigham and Women's Hospital, Boston, MA06/1996Internal Medicine
    Dana-Farber/Partners Cancer Care, Boston, MA06/1999Medical Oncology

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    James F. Amatruda, MD, PhD is Section Head of Basic and Translational Research in the Cancer and Blood Diseases Institute and the Division of Pediatric Hematology-Oncology at Children’s Hospital Los Angeles; and Professor of Pediatrics and Medicine at the Keck School of Medicine of the University of Southern California. He received his Bachelor’s degree in Biochemical Sciences from Harvard University and his MD,PhD from Washington University School of Medicine. He did internship and residency training in Internal Medicine at the Brigham and Women’s Hospital in Boston, MA, followed by fellowship training in Medical Oncology at Dana-Farber/Partners Cancer Care in Boston, MA. He was a Postdoctoral Fellow in the laboratory of Dr. Leonard Zon at Boston Children’s Hospital, Harvard Medical School. From 2005-2019, Dr. Amatruda was on the faculty of UT Southwestern Medical Center in Dallas, TX.

    Dr. Amatruda is a physician-scientist with a primary research and clinical focus on solid tumors of childhood including sarcomas, germ cell tumors and Wilms tumor. His lab has developed zebrafish models of genetic subtypes of pediatric solid tumors to better define their biology and to use that knowledge to identify and validate novel approaches for improved therapies. He has had long-standing leadership positions in the Children’s Oncology Group; serving as Chair for the Germ Cell Tumor Biology Committee and the Rare Tumors Biology Committee. He also serves as a member of the COG Solid Malignancies Integrated Translational Science Center Steering Committee, and on the Scientific Advisory Boards of the William Guy Forbeck Foundation, the Pablove Foundation, Curing Kids Cancer and the 1 Million 4 Anna Foundation.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Combined low-pass whole genome and targeted sequencing in liquid biopsies for pediatric solid tumors. NPJ Precis Oncol. 2023 Feb 20; 7(1):21. Christodoulou E, Yellapantula V, O'Halloran K, Xu L, Berry JL, Cotter JA, Zdanowicz A, Mascarenhas L, Amatruda JF, Ostrow D, Bootwalla M, Gai X, Navid F, Biegel JA. PMID: 36805676; PMCID: PMC9941464.
      View in: PubMed   Mentions:
    2. Evaluation of miR-371a-3p to predict viable germ cell tumor in patients with pure seminoma receiving retroperitoneal lymph node dissection. Andrology. 2022 Oct 18. Konneh B, Lafin JT, Howard J, Gerald T, Amini A, Savelyeva A, Woldu SL, Lewis CM, Jia L, Margulis V, Coleman N, Scarpini C, Frazier AL, Murray MJ, Amatruda JF, Bagrodia A. PMID: 36254623.
      View in: PubMed   Mentions: 1     Fields:    
    3. Advancing clinical and translational research in germ cell tumours (GCT): recommendations from the Malignant Germ Cell International Consortium. Br J Cancer. 2022 11; 127(9):1577-1583. Fonseca A, Lobo J, Hazard FK, Gell J, Nicholls PK, Weiss RS, Klosterkemper L, Volchenboum SL, Nicholson JC, Frazier AL, Amatruda JF, Bagrodia A, Lockley M, Murray MJ. PMID: 36229581; PMCID: PMC9596690.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. In vivo 3D profiling of site-specific human cancer cell morphotypes in zebrafish. J Cell Biol. 2022 11 07; 221(11). Segal D, Mazloom-Farsibaf H, Chang BJ, Roudot P, Rajendran D, Daetwyler S, Fiolka R, Warren M, Amatruda JF, Danuser G. PMID: 36155740; PMCID: PMC9516844.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    5. Response to commentary re: Clinicopathologic predictors of outcomes in children with stage I testicular germ cell tumors: A pooled post hoc analysis of trials from the Children's oncology group. J Pediatr Urol. 2022 Aug; 18(4):513-514. Singla N, Wong J, Singla S, Krailo M, Huang L, Shaikh F, Billmire D, Rescorla F, Ross J, Dicken B, Amatruda JF, Frazier AL, Bagrodia A. PMID: 35868999.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Clinicopathologic predictors of outcomes in children with stage I testicular germ cell tumors: A pooled post hoc analysis of trials from the Children's Oncology Group. J Pediatr Urol. 2022 Aug; 18(4):505-511. Singla N, Wong J, Singla S, Krailo M, Huang L, Shaikh F, Billmire D, Rescorla F, Ross J, Dicken B, Amatruda JF, Lindsay Frazier A, Bagrodia A. PMID: 35606324; PMCID: PMC9667350.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Dysregulated heparan sulfate proteoglycan metabolism promotes Ewing sarcoma tumor growth. Elife. 2022 03 14; 11. Vasileva E, Warren M, Triche TJ, Amatruda JF. PMID: 35285802; PMCID: PMC8942468.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    8. Pitfalls in the diagnosis of yolk sac tumor: Lessons from a clinical trial. Pediatr Blood Cancer. 2022 02; 69(2):e29451. Yang A, Patterson A, Pavlock T, Chen KS, Gagan J, Hatley ME, Frazier AL, Amatruda JF, Laetsch TW, Rakheja D. PMID: 34866303; PMCID: PMC9359435.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. A Multi-institutional Pooled Analysis Demonstrates That Circulating miR-371a-3p Alone is Sufficient for Testicular Malignant Germ Cell Tumor Diagnosis. Clin Genitourin Cancer. 2021 12; 19(6):469-479. Piao J, Lafin JT, Scarpini CG, Nu?o MM, Syring I, Dieckmann KP, Belge G, Ellinger J, Amatruda JF, Bagrodia A, Coleman N, Krailo MD, Frazier AL, Murray MJ. PMID: 34629299; PMCID: PMC9084514.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    10. The developmental origin of cancers defines basic principles of cisplatin resistance. Cancer Lett. 2021 10 28; 519:199-210. Skowron MA, Oing C, Bremmer F, Str?bel P, Murray MJ, Coleman N, Amatruda JF, Honecker F, Bokemeyer C, Albers P, Nettersheim D. PMID: 34320371.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    11. The Road Ahead for Circulating microRNAs in Diagnosis and Management of Testicular Germ Cell Tumors. Mol Diagn Ther. 2021 05; 25(3):269-271. Lafin JT, Murray MJ, Coleman N, Frazier AL, Amatruda JF, Bagrodia A. PMID: 33893623.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    12. Prioritization of Novel Agents for Patients with Rhabdomyosarcoma: A Report from the Children's Oncology Group (COG) New Agents for Rhabdomyosarcoma Task Force. J Clin Med. 2021 Apr 01; 10(7). Pacenta HL, Allen-Rhoades W, Langenau D, Houghton PJ, Keller C, Heske CM, Deel MD, Linardic CM, Shern JF, Stewart E, Turpin B, Harrison DJ, Khan J, Mascarenhas L, Skapek SX, Meyer WH, Hawkins DS, Chen EY, Amatruda JF, Hingorani P, Laetsch TW. PMID: 33915882; PMCID: PMC8037615.
      View in: PubMed   Mentions: 4  
    13. RAD21 is a driver of chromosome 8 gain in Ewing sarcoma to mitigate replication stress. Genes Dev. 2021 04 01; 35(7-8):556-572. Su XA, Ma D, Parsons JV, Replogle JM, Amatruda JF, Whittaker CA, Stegmaier K, Amon A. PMID: 33766983; PMCID: PMC8015718.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    14. Serum Small RNA Sequencing and miR-375 Assay Do Not Identify the Presence of Pure Teratoma at Postchemotherapy Retroperitoneal Lymph Node Dissection. Eur Urol Open Sci. 2021 Apr; 26:83-87. Lafin JT, Kenigsberg AP, Meng X, Abe D, Savelyeva A, Singla N, Woldu SL, Lotan Y, Mauck RJ, Lewis CM, Margulis V, Wong D, Jia L, Kapur P, Xu L, Speir RW, Chesnut GT, Frazier AL, Strand DW, Coleman N, Murray MJ, Amatruda JF, Bagrodia A. PMID: 33997822; PMCID: PMC8121258.
      View in: PubMed   Mentions: 13  
    15. Neonatal Malignant Disorders: Germ Cell Tumors. Clin Perinatol. 2021 03; 48(1):147-165. Shah R, Weil BR, Weldon CB, Amatruda JF, Frazier AL. PMID: 33583501.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Modeling the developmental origins of pediatric cancer to improve patient outcomes. Dis Model Mech. 2021 02 22; 14(2). Amatruda JF. PMID: 33619212; PMCID: PMC7927656.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    17. Germ Cell Tumor Cell Culture Techniques. Methods Mol Biol. 2021; 2195:65-76. Lafin JT, Amatruda JF, Bagrodia A. PMID: 32852757.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    18. Developing and Using a Data Commons for Understanding the Molecular Characteristics of Germ Cell Tumors. Methods Mol Biol. 2021; 2195:263-275. Ci B, Lin SY, Yao B, Luo D, Xu L, Krailo M, Murray MJ, Amatruda JF, Frazier AL, Xie Y. PMID: 32852769.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    19. Correction to: Germ Cell Tumor Cell Culture Techniques. Methods Mol Biol. 2021; 2195:C1. Lafin JT, Amatruda JF, Bagrodia A. PMID: 34453282.
      View in: PubMed   Mentions:    Fields:    
    20. Impact of circulating microRNA test (miRNA-371a-3p) on appropriateness of treatment and cost outcomes in patients with Stage I non-seminomatous germ cell tumours. BJU Int. 2021 07; 128(1):57-64. Bagrodia A, Savelyeva A, Lafin JT, Speir RW, Chesnut GT, Frazier AL, Woldu SL, Margulis V, Murray MJ, Amatruda JF, Lotan Y. PMID: 33124175.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    21. Outcomes of adolescent males with extracranial metastatic germ cell tumors: A report from the Malignant Germ Cell Tumor International Consortium. Cancer. 2021 01 15; 127(2):193-202. Shaikh F, Stark D, Fonseca A, Dang H, Xia C, Krailo M, Pashankar F, Rodriguez-Galindo C, Olson TA, Nicholson JC, Murray MJ, Amatruda JF, Billmire D, Stoneham S, Frazier AL. PMID: 33079404.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    22. Real-World Application of Pre-Orchiectomy miR-371a-3p Test in Testicular Germ Cell Tumor Management. J Urol. 2021 Jan; 205(1):137-144. Badia RR, Abe D, Wong D, Singla N, Savelyeva A, Chertack N, Woldu SL, Lotan Y, Mauck R, Ouyang D, Meng X, Lewis CM, Majmudar K, Jia L, Kapur P, Xu L, Frazier AL, Margulis V, Strand DW, Coleman N, Murray MJ, Amatruda JF, Lafin JT, Bagrodia A. PMID: 32856980.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    23. Development of a Data Model and Data Commons for Germ Cell Tumors. JCO Clin Cancer Inform. 2020 06; 4:555-566. Ci B, Yang DM, Krailo M, Xia C, Yao B, Luo D, Zhou Q, Xiao G, Xu L, Skapek SX, Murray MM, Amatruda JF, Klosterkemper L, Shaikh F, Faure-Conter C, Fresneau B, Volchenboum SL, Stoneham S, Lopes LF, Nicholson J, Frazier AL, Xie Y. PMID: 32568554; PMCID: PMC7328105.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    24. Birth Characteristics and Risk of Early-Onset Synovial Sarcoma. Cancer Epidemiol Biomarkers Prev. 2020 06; 29(6):1162-1167. Wiemels JL, Wiemels JL, Wang R, Feng Q, Clark CJ, Amatruda JF, Rubin E, Yee AC, Morimoto LM, Metayer C, Ma X. PMID: 32245786; PMCID: PMC7605594.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    25. GCNA Preserves Genome Integrity and Fertility Across Species. Dev Cell. 2020 01 06; 52(1):38-52.e10. Bhargava V, Goldstein CD, Russell L, Xu L, Ahmed M, Li W, Casey A, Servage K, Kollipara R, Picciarelli Z, Kittler R, Yatsenko A, Carmell M, Orth K, Amatruda JF, Yanowitz JL, Buszczak M. PMID: 31839537; PMCID: PMC6946843.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    26. Serum MicroRNA-371a-3p Levels Predict Viable Germ Cell Tumor in Chemotherapy-na�ve Patients Undergoing Retroperitoneal Lymph Node Dissection. Eur Urol. 2020 02; 77(2):290-292. Lafin JT, Singla N, Woldu SL, Lotan Y, Lewis CM, Majmudar K, Savelyeva A, Kapur P, Margulis V, Strand DW, Murray MJ, Amatruda JF, Bagrodia A. PMID: 31699528; PMCID: PMC7756387.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    27. Genetics of testicular germ cell tumors. Curr Opin Urol. 2019 07; 29(4):344-349. Singla N, Lafin JT, Ghandour RA, Kaffenberger S, Amatruda JF, Bagrodia A. PMID: 31045925; PMCID: PMC6659740.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    28. Detection of Relapse by Tumor Markers Versus Imaging in Children and Adolescents With Nongerminomatous Malignant Germ Cell Tumors: A Report From the Children's Oncology Group. J Clin Oncol. 2019 02 10; 37(5):396-402. Fonseca A, Xia C, Lorenzo AJ, Krailo M, Olson TA, Pashankar F, Malogolowkin MH, Amatruda JF, Billmire DF, Rodriguez-Galindo C, Frazier AL, Shaikh F. PMID: 30576269; PMCID: PMC6553816.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    29. pouC Regulates Expression of bmp4 During Atrioventricular Canal Formation in Zebrafish. Dev Dyn. 2019 02; 248(2):173-188. Bhakta M, Padanad MS, Harris JP, Lubczyk C, Amatruda JF, Munshi NV. PMID: 30444277; PMCID: PMC6340724.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    30. Differences in DNA methylation profiles by histologic subtype of paediatric germ cell tumours: a report from the Children's Oncology Group. Br J Cancer. 2018 10; 119(7):864-872. Williams LA, Mills L, Hooten AJ, Langer E, Roesler M, Frazier AL, Krailo M, Nelson HH, Bestrashniy J, Amatruda JF, Poynter JN. PMID: 30287918; PMCID: PMC6189207.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    31. Klinefelter syndrome in males with germ cell tumors: A report from the Children's Oncology Group. Cancer. 2018 10 01; 124(19):3900-3908. Williams LA, Pankratz N, Lane J, Krailo M, Roesler M, Richardson M, Frazier AL, Amatruda JF, Poynter JN. PMID: 30291793; PMCID: PMC6241518.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    32. Mutations in microRNA processing genes in Wilms tumors derepress the IGF2 regulator PLAG1. Genes Dev. 2018 08 01; 32(15-16):996-1007. Chen KS, Stroup EK, Budhipramono A, Rakheja D, Nichols-Vinueza D, Xu L, Stuart SH, Shukla AA, Fraire C, Mendell JT, Amatruda JF. PMID: 30026293; PMCID: PMC6075147.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    33. Integrative Bayesian Analysis Identifies Rhabdomyosarcoma Disease Genes. Cell Rep. 2018 07 03; 24(1):238-251. Xu L, Zheng Y, Liu J, Rakheja D, Singleterry S, Laetsch TW, Shern JF, Khan J, Triche TJ, Hawkins DS, Amatruda JF, Skapek SX. PMID: 29972784; PMCID: PMC7293769.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    34. Practice Patterns and Impact of Postchemotherapy Retroperitoneal Lymph Node Dissection on Testicular Cancer Outcomes. Eur Urol Oncol. 2018 08; 1(3):242-251. Woldu SL, Moore JA, Ci B, Freifeld Y, Clinton TN, Aydin AM, Singla N, Laura-Maria K, Hutchinson RC, Amatruda JF, Sagalowsky A, Lotan Y, Arriaga Y, Margulis V, Xie Y, Bagrodia A. PMID: 31058267; PMCID: PMC6494089.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    35. Is carboplatin-based chemotherapy as effective as cisplatin-based chemotherapy in the treatment of advanced-stage dysgerminoma in children, adolescents and young adults? Gynecol Oncol. 2018 08; 150(2):253-260. Shah R, Xia C, Krailo M, Amatruda JF, Arul SG, Billmire DF, Brady WE, Covens A, Gershenson DM, Hale JP, Hurteau J, Murray MJ, Nicholson JC, Olson TA, Pashankar F, Rodriguez-Galindo C, Shaikh F, Stark D, Frazier AL, Stoneham S. PMID: 29884437.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    36. PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis. Elife. 2018 06 05; 7. Kendall GC, Watson S, Xu L, LaVigne CA, Murchison W, Rakheja D, Skapek SX, Tirode F, Delattre O, Amatruda JF. PMID: 29869612; PMCID: PMC5988421.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    37. Comparison of carboplatin versus cisplatin in the treatment of paediatric extracranial malignant germ cell tumours: A report of the Malignant Germ Cell International Consortium. Eur J Cancer. 2018 07; 98:30-37. Frazier AL, Stoneham S, Rodriguez-Galindo C, Dang H, Xia C, Olson TA, Murray MJ, Amatruda JF, Shaikh F, Pashankar F, Billmire D, Krailo M, Stark D, Brougham MFH, Nicholson JC, Hale JP. PMID: 29859339.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    38. EGF Receptor and mTORC1 Are Novel Therapeutic Targets in Nonseminomatous Germ Cell Tumors. Mol Cancer Ther. 2018 05; 17(5):1079-1089. Chen KS, Fustino NJ, Shukla AA, Stroup EK, Budhipramono A, Ateek C, Stuart SH, Yamaguchi K, Kapur P, Frazier AL, Lum L, Looijenga LHJ, Laetsch TW, Rakheja D, Amatruda JF. PMID: 29483210; PMCID: PMC5932259.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    39. Pediatric Germ Cell Tumors: A Developmental Perspective. Adv Urol. 2018; 2018:9059382. Pierce JL, Frazier AL, Amatruda JF. PMID: 29515628; PMCID: PMC5817207.
      View in: PubMed   Mentions: 22  
    40. Adolescents and Young Adults With a "Rare" Cancer: Getting Past Semantics to Optimal Care for Patients With Germ Cell Tumors. Oncologist. 2018 02; 23(2):272. Stoneham SJ, Hale JP, Rodriguez-Galindo C, Dang H, Olson T, Murray M, Amatruda JF, Thornton C, Arul GS, Billmire D, Krailo M, Stark D, Covens A, Hurteau J, Stenning S, Nicholson JC, Gershenson D, Frazier AL. PMID: 29449513; PMCID: PMC5813761.
      View in: PubMed   Mentions:    Fields:    
    41. Gonadal dysgenesis is associated with worse outcomes in patients with ovarian nondysgerminomatous tumors: A report of the Children's Oncology Group AGCT 0132 study. Pediatr Blood Cancer. 2018 04; 65(4). Dicken BJ, Billmire DF, Krailo M, Xia C, Shaikh F, Cullen JW, Olson TA, Pashankar F, Malogolowkin MH, Amatruda JF, Rescorla FJ, Egler RA, Ross JH, Rodriguez-Galindo C, Frazier AL. PMID: 29286555; PMCID: PMC6219870.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    42. Differences at Presentation and Treatment of Testicular Cancer in Hispanic Men: Institutional and National Hospital-based Analyses. Urology. 2018 02; 112:103-111. Woldu SL, Aydin AM, Rao AV, Hutchinson RC, Singla N, Clinton TN, Krabbe LM, Passoni NM, Raj GV, Miller DS, Amatruda JF, Sagalowsky AI, Lotan Y, Arriaga Y, Margulis V, Bagrodia A. PMID: 29079210.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    43. Family history of cancer in children and adolescents with germ cell tumours: a report from the Children's Oncology Group. Br J Cancer. 2018 01; 118(1):121-126. Poynter JN, Richardson M, Roesler M, Krailo M, Amatruda JF, Frazier AL. PMID: 29065103; PMCID: PMC5765220.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    44. Retrotransposons Mimic Germ Plasm Determinants to Promote Transgenerational Inheritance. Curr Biol. 2017 Oct 09; 27(19):3010-3016.e3. Tiwari B, Kurtz P, Jones AE, Wylie A, Amatruda JF, Boggupalli DP, Gonsalvez GB, Abrams JM. PMID: 28966088; PMCID: PMC5639916.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    45. Variants in BAK1, SPRY4, and GAB2 are associated with pediatric germ cell tumors: A report from the children's oncology group. Genes Chromosomes Cancer. 2017 07; 56(7):548-558. Marcotte EL, Pankratz N, Amatruda JF, Frazier AL, Krailo M, Davies S, Starr JR, Lau CC, Roesler M, Langer E, Hallstrom C, Hooten AJ, Poynter JN. PMID: 28295819; PMCID: PMC5612339.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    46. Reduced and Compressed Cisplatin-Based Chemotherapy in Children and Adolescents With Intermediate-Risk Extracranial Malignant Germ Cell Tumors: A Report From the Children's Oncology Group. J Clin Oncol. 2017 Apr 10; 35(11):1203-1210. Shaikh F, Cullen JW, Olson TA, Pashankar F, Malogolowkin MH, Amatruda JF, Villaluna D, Krailo M, Billmire DF, Rescorla FJ, Egler RA, Dicken BJ, Ross JH, Schlatter M, Rodriguez-Galindo C, Frazier AL. PMID: 28240974; PMCID: PMC5455599.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    47. Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):1649-1654. Moon J, Zhou H, Zhang LS, Tan W, Liu Y, Zhang S, Morlock LK, Bao X, Palecek SP, Feng JQ, Williams NS, Amatruda JF, Olson EN, Bassel-Duby R, Lum L. PMID: 28143939; PMCID: PMC5320972.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    48. Testicular germ cell tumor genomics. Curr Opin Urol. 2017 01; 27(1):41-47. Woldu SL, Amatruda JF, Bagrodia A. PMID: 27584029; PMCID: PMC6368344.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    49. Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation. Nat Med. 2017 01; 23(1):79-90. Lu Z, Xie J, Wu G, Shen J, Collins R, Chen W, Kang X, Luo M, Zou Y, Huang LJ, Amatruda JF, Slone T, Winick N, Scherer PE, Zhang CC. PMID: 27941793; PMCID: PMC6956990.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    50. Genetic inhibition of autophagy promotes p53 loss-of-heterozygosity and tumorigenesis. Oncotarget. 2016 10 18; 7(42):67919-67933. Lee E, Wei Y, Zou Z, Tucker K, Rakheja D, Levine B, Amatruda JF. PMID: 27655644; PMCID: PMC5356529.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    51. Risk of second gonadal cancers in women and children with germ cell tumors. Cancer. 2016 07 01; 122(13):2076-82. Liao ZW, Rodrigues MC, Poynter JN, Amatruda JF, Rodriguez-Galindo C, Frazier AL. PMID: 27152727.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    52. Paediatric extracranial germ-cell tumours. Lancet Oncol. 2016 04; 17(4):e149-e162. Shaikh F, Murray MJ, Amatruda JF, Coleman N, Nicholson JC, Hale JP, Pashankar F, Stoneham SJ, Poynter JN, Olson TA, Billmire DF, Stark D, Rodriguez-Galindo C, Frazier AL. PMID: 27300675.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    53. Zebrafish as a Model for the Study of Solid Malignancies. Methods Mol Biol. 2016; 1451:121-42. Kendall GC, Amatruda JF. PMID: 27464805.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    54. Zebrafish Germ Cell Tumors. Adv Exp Med Biol. 2016; 916:479-94. Sanchez A, Amatruda JF. PMID: 27165367; PMCID: PMC4959914.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    55. Biochemical Analysis of Tankyrase Activity in Zebrafish In Vitro and In Vivo. Methods Mol Biol. 2016; 1481:95-100. Moon J, Amatruda JF. PMID: 27590155.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    56. p53 genes function to restrain mobile elements. Genes Dev. 2016 Jan 01; 30(1):64-77. Wylie A, Jones AE, D'Brot A, Lu WJ, Kurtz P, Moran JV, Rakheja D, Chen KS, Hammer RE, Comerford SA, Amatruda JF, Abrams JM. PMID: 26701264; PMCID: PMC4701979.
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    57. Is adjuvant chemotherapy indicated in ovarian immature teratomas? A combined data analysis from the Malignant Germ Cell Tumor International Collaborative. Cancer. 2016 Jan 15; 122(2):230-7. Pashankar F, Hale JP, Dang H, Krailo M, Brady WE, Rodriguez-Galindo C, Nicholson JC, Murray MJ, Bilmire DF, Stoneham S, Arul GS, Olson TA, Stark D, Shaikh F, Amatruda JF, Covens A, Gershenson DM, Frazier AL. PMID: 26485622; PMCID: PMC5134834.
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    58. Pediatric and Adolescent Extracranial Germ Cell Tumors: The Road to Collaboration. J Clin Oncol. 2015 Sep 20; 33(27):3018-28. Olson TA, Murray MJ, Rodriguez-Galindo C, Nicholson JC, Billmire DF, Krailo MD, Dang HM, Amatruda JF, Thornton CM, Arul GS, Stoneham SJ, Pashankar F, Stark D, Shaikh F, Gershenson DM, Covens A, Hurteau J, Stenning SP, Feldman DR, Grimison PS, Huddart RA, Sweeney C, Powles T, Lopes LF, dos Santos Agular S, Chinnaswamy G, Khaleel S, Abouelnaga S, Hale JP, Frazier AL. PMID: 26304902; PMCID: PMC4979195.
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    59. Surveillance after initial surgery for Stage I pediatric and adolescent boys with malignant testicular germ cell tumors: Report from the Children's Oncology Group. J Pediatr Surg. 2015 Jun; 50(6):1000-3. Rescorla FJ, Ross JH, Billmire DF, Dicken BJ, Villaluna D, Davis MM, Krailo M, Cullen JW, Olson TA, Egler RA, Amatruda JF, Rodrigues-Galindo C, Frazier AL. PMID: 25812445.
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    60. Revised risk classification for pediatric extracranial germ cell tumors based on 25 years of clinical trial data from the United Kingdom and United States. J Clin Oncol. 2015 Jan 10; 33(2):195-201. Frazier AL, Hale JP, Rodriguez-Galindo C, Dang H, Olson T, Murray MJ, Amatruda JF, Thornton C, Arul GS, Billmire D, Shaikh F, Pashankar F, Stoneham S, Krailo M, Nicholson JC. PMID: 25452439; PMCID: PMC4279239.
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    61. Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours. Nat Commun. 2014 Sep 05; 2:4802. Rakheja D, Chen KS, Liu Y, Shukla AA, Schmid V, Chang TC, Khokhar S, Wickiser JE, Karandikar NJ, Malter JS, Mendell JT, Amatruda JF. PMID: 25190313; PMCID: PMC4159681.
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    62. Spotlight on zebrafish: translational impact. Dis Model Mech. 2014 Jul; 7(7):731-3. Patton EE, Dhillon P, Amatruda JF, Ramakrishnan L. PMID: 24973741; PMCID: PMC4073261.
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    63. Adolescents and young adults with a "rare" cancer: getting past semantics to optimal care for patients with germ cell tumors. Oncologist. 2014 Jul; 19(7):689-92. Stoneham SJ, Hale JP, Rodriguez-Galindo C, Dang H, Olson T, Murray M, Amatruda JF, Thornton C, Arul GS, Billmire D, Krailo M, Stark D, Covens A, Hurteau J, Stenning S, Nicholson JC, Gershenson D, Frazier AL. PMID: 24899644; PMCID: PMC4077446.
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    64. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell. 2014 Apr 24; 157(3):565-79. Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Aroumougame A, Shah AM, Szweda LI, Sadek HA. PMID: 24766806; PMCID: PMC4104514.
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    65. Autophagy is essential for cardiac morphogenesis during vertebrate development. Autophagy. 2014 Apr; 10(4):572-87. Lee E, Koo Y, Ng A, Wei Y, Luby-Phelps K, Juraszek A, Xavier RJ, Cleaver O, Levine B, Amatruda JF. PMID: 24441423; PMCID: PMC4091146.
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    66. DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors. BMC Cancer. 2013 Jun 27; 13:313. Amatruda JF, Ross JA, Christensen B, Fustino NJ, Chen KS, Hooten AJ, Nelson H, Kuriger JK, Rakheja D, Frazier AL, Poynter JN. PMID: 23806198; PMCID: PMC3701494.
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    67. A big catch for germ cell tumour research. PLoS Genet. 2013 Apr; 9(4):e1003481. Chen KS, Amatruda JF. PMID: 23593043; PMCID: PMC3623754.
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    68. The development of highly potent inhibitors for porcupine. J Med Chem. 2013 Mar 28; 56(6):2700-4. Wang X, Moon J, Dodge ME, Pan X, Zhang L, Hanson JM, Tuladhar R, Ma Z, Shi H, Williams NS, Amatruda JF, Carroll TJ, Lum L, Chen C. PMID: 23477365; PMCID: PMC3631274.
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    69. Children's Oncology Group's 2013 blueprint for research: rare tumors. Pediatr Blood Cancer. 2013 Jun; 60(6):1016-21. Rodriguez-Galindo C, Krailo M, Frazier L, Chintagumpala M, Amatruda J, Katzenstein H, Malogolowkin M, Spector L, Pashankar F, Meyers R, Tomlinson G, COG Rare Tumors Disease Committee. PMID: 23255219; PMCID: PMC4304764.
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    70. C/EBP transcription factors mediate epicardial activation during heart development and injury. Science. 2012 Dec 21; 338(6114):1599-603. Huang GN, Thatcher JE, McAnally J, Kong Y, Qi X, Tan W, DiMaio JM, Amatruda JF, Gerard RD, Hill JA, Bassel-Duby R, Olson EN. PMID: 23160954; PMCID: PMC3613149.
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    71. Multiple isoforms of CDC25 oppose ATM activity to maintain cell proliferation during vertebrate development. Mol Cancer Res. 2012 Nov; 10(11):1451-61. Verduzco D, Dovey JS, Shukla AA, Kodym E, Skaug BA, Amatruda JF. PMID: 22986406; PMCID: PMC3511848.
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    72. Fetal and neonatal germ cell tumors. Semin Fetal Neonatal Med. 2012 Aug; 17(4):222-230. Frazier AL, Weldon C, Amatruda J. PMID: 22647545.
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    73. Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine. J Biol Chem. 2012 Jun 29; 287(27):23246-54. Dodge ME, Moon J, Tuladhar R, Lu J, Jacob LS, Zhang LS, Shi H, Wang X, Moro E, Mongera A, Argenton F, Karner CM, Carroll TJ, Chen C, Amatruda JF, Lum L. PMID: 22593577; PMCID: PMC3391103.
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    74. Studying synthetic lethal interactions in the zebrafish system: insight into disease genes and mechanisms. Dis Model Mech. 2012 Jan; 5(1):33-7. Hajeri VA, Amatruda JF. PMID: 22107871; PMCID: PMC3255541.
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    75. A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis. Dis Model Mech. 2012 Jan; 5(1):95-106. Leacock SW, Basse AN, Chandler GL, Kirk AM, Rakheja D, Amatruda JF. PMID: 21979944; PMCID: PMC3255547.
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    76. Mutation in the type IB bone morphogenetic protein receptor Alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish. Proc Natl Acad Sci U S A. 2011 Aug 09; 108(32):13153-8. Neumann JC, Chandler GL, Damoulis VA, Fustino NJ, Lillard K, Looijenga L, Margraf L, Rakheja D, Amatruda JF. PMID: 21775673; PMCID: PMC3156187.
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    77. High-resolution array CGH identifies common mechanisms that drive embryonal rhabdomyosarcoma pathogenesis. Genes Chromosomes Cancer. 2011 Jun; 50(6):397-408. Paulson V, Chandler G, Rakheja D, Galindo RL, Wilson K, Amatruda JF, Cameron S. PMID: 21412928.
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    78. Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling. Sci Signal. 2011 Jan 25; 4(157):ra4. Jacob LS, Wu X, Dodge ME, Fan CW, Kulak O, Chen B, Tang W, Wang B, Amatruda JF, Lum L. PMID: 21266715; PMCID: PMC3790583.
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    79. Analysis of cell proliferation, senescence, and cell death in zebrafish embryos. Methods Cell Biol. 2011; 101:19-38. Verduzco D, Amatruda JF. PMID: 21550438; PMCID: PMC3870180.
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    80. Zebrafish models of germ cell tumor. Methods Cell Biol. 2011; 105:3-24. Neumann JC, Lillard K, Damoulis V, Amatruda JF. PMID: 21951524; PMCID: PMC3932324.
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    81. Breast cancer between faith and medicine: the Peres Maldonado ex-voto. Med Humanit. 2010 Dec; 36(2):112-4. Pon L, Amatruda JF. PMID: 21393294.
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    82. Trends in incidence and survival of pediatric and adolescent patients with germ cell tumors in the United States, 1975 to 2006. Cancer. 2010 Oct 15; 116(20):4882-91. Poynter JN, Amatruda JF, Ross JA. PMID: 20597129; PMCID: PMC3931133.
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    83. Effect of vascular cadherin knockdown on zebrafish vasculature during development. PLoS One. 2010 Jan 20; 5(1):e8807. Mitchell IC, Brown TS, Terada LS, Amatruda JF, Nwariaku FE. PMID: 20098718; PMCID: PMC2808391.
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    84. Identification of a heritable model of testicular germ cell tumor in the zebrafish. Zebrafish. 2009 Dec; 6(4):319-27. Neumann JC, Dovey JS, Chandler GL, Carbajal L, Amatruda JF. PMID: 20047465; PMCID: PMC2811880.
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    85. p53 ancestry: gazing through an evolutionary lens. Nat Rev Cancer. 2009 10; 9(10):758-62. Lu WJ, Amatruda JF, Abrams JM. PMID: 19776745.
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    86. Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg Med Chem Lett. 2009 Jul 15; 19(14):3825-7. Lu J, Ma Z, Hsieh JC, Fan CW, Chen B, Longgood JC, Williams NS, Amatruda JF, Lum L, Chen C. PMID: 19410457; PMCID: PMC2709695.
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    87. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol. 2009 Feb; 5(2):100-7. Chen B, Dodge ME, Tang W, Lu J, Ma Z, Fan CW, Wei S, Hao W, Kilgore J, Williams NS, Roth MG, Amatruda JF, Chen C, Lum L. PMID: 19125156; PMCID: PMC2628455.
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    88. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell. 2008 May 30; 133(5):864-77. Sidi S, Sanda T, Kennedy RD, Hagen AT, Jette CA, Hoffmans R, Pascual J, Imamura S, Kishi S, Amatruda JF, Kanki JP, Green DR, D'Andrea AA, Look AT. PMID: 18510930; PMCID: PMC2719897.
      View in: PubMed   Mentions: 177     Fields:    Translation:HumansAnimalsCells
    89. Genetic models of cancer in zebrafish. Int Rev Cell Mol Biol. 2008; 271:1-34. Amatruda JF, Patton EE. PMID: 19081540.
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    90. Analysis of the cell cycle in zebrafish embryos. Methods Cell Biol. 2004; 76:109-25. Shepard JL, Stern HM, Pfaff KL, Amatruda JF. PMID: 15602874.
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